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Jan 11

How Long Does It Take For Ozempic To Work For Weight Loss 2024 – Deccan Herald

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**Draft:**

Ozempic is a once-weekly injectable medication that helps lower blood sugar in adults with type 2 diabetes. But did you know that it can also help you lose weight? In this article, we will explore how Ozempic works for weight loss, and what you should know before trying it.

Ozempic contains semaglutide, a synthetic version of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1). GLP-1 is produced by the gut after eating, and it has several effects on the body, such as stimulating insulin secretion, slowing down gastric emptying, and reducing appetite. By mimicking GLP-1, semaglutide can help regulate blood sugar and promote weight loss.

The FDA approved semaglutide for weight loss in June 2021, under the brand name Wegovy. Wegovy is a higher dose of semaglutide than Ozempic, and it is indicated for chronic weight management in adults who are obese or overweight with weight-related medical conditions. However, some people have been using Ozempic off-label for weight loss, as it is cheaper and more widely available than Wegovy.

The aim of this article is to explain how Ozempic works for weight loss, how effective and safe it is, and what are its limitations. However, before starting any new medication, you should always consult your doctor and follow their advice.

## Mechanism of Action

- Explain how Ozempic works by activating GLP-1 receptors in the brain and the gut, and how this affects appetite, digestion, and metabolism

- Provide some evidence from animal and human studies that support the role of GLP-1 in weight loss

- Emphasize that Ozempic is not a magic pill, and that it requires lifestyle changes, such as diet and exercise, to achieve optimal results

**Draft:**

Ozempic works by activating GLP-1 receptors in the brain and the gut, which are involved in regulating appetite, digestion, and metabolism. By stimulating these receptors, Ozempic can reduce hunger, increase satiety, and decrease food intake. Ozempic can also slow down the movement of food from the stomach to the intestines, which can make you feel fuller for longer and reduce the absorption of calories. Additionally, Ozempic can increase the production of insulin, which can lower blood glucose and prevent fat storage.

Several animal and human studies have shown that GLP-1 can induce weight loss by affecting the central and peripheral nervous systems. For example, a study in mice found that GLP-1 can activate neurons in the hypothalamus, a brain region that controls appetite and energy balance, and inhibit neurons in the brainstem, a brain region that regulates gastric functions. Another study in humans found that GLP-1 can reduce the activity of the reward system in the brain, which is associated with food cravings and overeating.

However, Ozempic is not a magic pill that can make you lose weight without any effort. Ozempic is meant to be used as an adjunct to a reduced-calorie diet and increased physical activity, as these lifestyle changes can enhance the effects of the medication and improve your overall health. Ozempic is also not a cure for obesity, and it may not work for everyone. Ozempic is only approved for type 2 diabetes, and its off-label use for weight loss is not recommended by the FDA or the manufacturer.

## Effectiveness

- Compare the results of clinical trials for Ozempic and Wegovy, focusing on the outcomes of weight loss and blood sugar control

- Highlight the strengths and limitations of the studies, such as the sample size, duration, and design

- Emphasize that the effectiveness of Ozempic for weight loss depends on individual factors, such as adherence, dose, and medical history

**Draft:**

Ozempic and Wegovy have both shown promising results in clinical trials, but their effectiveness for weight loss may vary depending on the dose and the condition they are prescribed for. Ozempic is expected to be less effective for weight loss than Wegovy, as it has a lower dose of semaglutide. Ozempic is also designed for type 2 diabetes, while Wegovy is designed for weight loss.

For type 2 diabetes, Ozempic's effectiveness was demonstrated in the SUSTAIN 6 trial, which involved 3,297 participants with type 2 diabetes and cardiovascular risk factors. The participants were randomly assigned to receive either Ozempic or placebo injections once a week for 104 weeks, along with standard diabetes care. The results showed that Ozempic was superior to placebo in lowering blood sugar levels, with an average reduction of 1.05% to 1.41% in HbA1c, depending on the dose, compared to 0.36% for placebo. The participants on Ozempic also experienced weight loss, with an average of 3.7 kg to 4.5 kg, depending on the dose, compared to 0.7 kg for placebo. However, the study had some limitations, such as the short duration, the exclusion of patients with renal impairment, and the potential for bias due to the sponsor's involvement.

For weight loss, Wegovy's effectiveness was demonstrated in the STEP 1 trial, which involved 1,961 participants who were either obese or overweight with weight-related medical conditions. The participants were randomly assigned to receive either Wegovy or placebo injections once a week for 68 weeks, along with lifestyle intervention. The results showed that Wegovy was superior to placebo in reducing body weight, with an average weight loss of 14.9% to 15.3%, depending on the dose, compared to 2.4% for placebo. The participants on Wegovy also experienced improvements in blood pressure, cholesterol, and blood sugar levels. However, the study had some limitations, such as the lack of a comparator group with another weight loss medication, and the potential for bias due to the sponsor's involvement.

The effectiveness of Ozempic for weight loss may depend on individual factors, such as adherence to the medication regimen, lifestyle changes, and medical history. Therefore, the results of the clinical trials may not reflect the real-world outcomes for every patient. It is important to follow your doctor's instructions and monitor your progress regularly when using Ozempic for weight loss.

## Safety and Limitations

- Explain the possible side effects and precautions of Ozempic for weight loss, and what to do in case of overdose or missed dose

- Provide some information on the contraindications and interactions of Ozempic for weight loss, and who should not use it

- Mention some alternative options for weight loss, and how they compare to Ozempic for weight loss in terms of safety and effectiveness

**Draft:**

Ozempic for weight loss may cause some side effects, such as nausea, vomiting, diarrhea, constipation, stomach pain, headache, dizziness, fatigue, injection site reactions, and low blood sugar. These side effects are usually mild and temporary, and may improve as your body adjusts to the medication. However, if they persist or worsen, or if you experience any serious side effects, such as severe allergic reactions, pancreatitis, gallbladder problems, kidney problems, or thyroid problems, you should contact your doctor immediately. You should also tell your doctor about any other medications, supplements, or herbal products that you are taking, as they may interact with Ozempic for weight loss.

If you take too much Ozempic for weight loss, you may experience symptoms of overdose, such as severe nausea, vomiting, diarrhea, dehydration, or low blood sugar. You should seek emergency medical attention if this happens. You should also carry a source of glucose, such as candy, juice, or glucose tablets, to treat low blood sugar if it occurs. You should also wear a medical alert bracelet or carry a card that identifies you as a user of Ozempic for weight loss.

If you miss a dose of Ozempic for weight loss, you should take it as soon as you remember, as long as it is within 3 days of your scheduled dose. If it is more than 3 days past your scheduled dose, you should skip the missed dose and take the next dose on your regular day. You should not take two doses in the same week, or take more than one dose in a day. You should also keep track of your doses and injections, and contact your doctor if you have any questions or concerns.

Ozempic for weight loss is not suitable for everyone, and it has some contraindications and interactions. You should not use Ozempic for weight loss if you have a personal or family history of medullary thyroid carcinoma, a rare type of thyroid cancer, or multiple endocrine neoplasia syndrome type 2, a genetic disorder that causes tumors in the endocrine glands. You should also not use Ozempic for weight loss if you are allergic to semaglutide or any of the ingredients in Ozempic. You should also be cautious if you have

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How Long Does It Take For Ozempic To Work For Weight Loss 2024 - Deccan Herald

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