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Cancers are often heavily reliant on breaking down fats for their growth and spread, and could be treated by a highly innovative combination of new drugs and dietary changes, a major new study concludes.

The landmark research used a surgical iKnife to analyse vaporised cancer tissue and identified a metabolic weakness in cancer that could be amenable to a new metabolic treatment.

Researchers found that targeting cancers ability to process fat using a new class of drugs could halt tumour growth in mice, but only when combined with a diet free of fats.

The study, led by scientists at The Institute of Cancer Research, London, and colleagues atImperial College London, opens up the possibility of drugs and diet cancer treatments combining precision medicine and dietary changes.

But the researchers stress that the proposed dietary changes would only apply in combination with a specific new class of drugs and that they are not suggesting they would have any benefit in any other clinical context.

The research also showed the potential for the iKnife to instantly pick out tumours with the metabolic weakness during surgery by analysing the smoke given off as tissue is burned during excisions.

Scientists looked at cancer cells in the lab and patient-derived tumours to search for metabolic fingerprints chemical patterns left behind by the inner workings of cells.

They used an analytical function connected to the iKnife, which cuts through tissue by rapidly heating it, to sift through the smoke from vaporised tissue for crucial clues about cellular metabolism.

The research was funded by The Institute of Cancer Research (ICR) a charity and research institute andCancer Grand Challenges, and ispublished in the prestigious journalCell.

In the new study, the scientists found that a molecule called PI3K which is vital to the growth and survival of cancer cells has a key role in triggering the release of arachidonic acid, a key omega-6 fat.

PI3K is often mutated in many cancers, including breast, gynaecological and bowel cancers.

The researchers found that the mutant form of PI3K sets in motion a chain of events involving another key molecule, cPLA2, which releases arachidonic acid. That in turn fuels the uncontrolled growth and spread of cancer.

The team then showed in studies in mice that a new class of drugs called cPLA2 inhibitors which are in clinical trials for the treatment of various inflammatory conditions could be adapted to treat fat-reliant cancers. But the drugs only worked when combined with dietary changes to restrict consumption of fat.

When mice were treated with a drug that inhibits cPLA2 and also at the same time fed a plant-based, fat-free diet, tumours with mutant PI3K stopped growing and spreading. However, when mice were fed a Western diet high in omega-6 fatty acids, the cPLA2 inhibitor was not effective.

The researchers believe that targeting cPLA2 is only effective when there are no dietary sources of arachidonic acid or some other fats to fuel the cancer. In other words, a fat-free, plant-based diet is necessary for these drugs to be effective.

The findings only apply to the use of these experimental cPLA2 inhibitors. They do not imply that the presence of fat could interfere with any existing cancer drugs, nor that the dietary fat restriction alone halts tumour growth.

The study suggests that arachidonic acid could be a metabolic biomarker a measurable indicator of the processes going on within cancer cells.

iKnife technology can detect whether tissue is cancerous within seconds during surgery, but this is the first study where it has been used to track the biology of the tumours. It raises the prospect that the iKnife could in future be used during surgery to detect tumours with a heavy reliance on fat, so patients could receive metabolic treatment.

Next, researchers are hoping to test the iKnife approach in a clinical trial to pick out patients who could benefit from being treated with drugs blocking cPLA2 alongside changes in their diet.

Dr George Poulogiannis, Leader of the Signalling and Cancer Metabolism Team at The Institute of Cancer Research, London, said:

We have known for a long time that cancers have genetic weaknesses that can be targeted by treatment, but our study shows that they can also be prone to specific metabolic vulnerabilities.

We have found that tumours are often heavily reliant on specific fats and their products to fuel their growth and spread, and that denying them the ability to process these could be an effective treatment.

Our study shows that stopping a specific subtype of cancers from being able to release a key omega-6 fat known as arachidonic acid could be effective as a treatment, but only if sources of this fat are also cut out of the diet. These findings in mice therefore highlight the role of nutrition in the response to the proposed drug therapy.

We also show that analysing cancers metabolic fingerprint can be a key tool in understanding, diagnosing and treating the disease. Our research raises the prospect that in future we could analyse cancers metabolic fingerprint while patients are on the operating table using the iKnife, and where appropriate match them to a combined drug and diet treatment.

Professor Paul Workman, Chief Executive of The Institute of Cancer Research, London, said:

This is an exciting and important study that shows it may be possible to understand and treat cancer by looking at so-called metabolic fingerprints. The new findings identify a specific metabolic weakness that could be amenable to a highly innovative new cancer treatment based on two essential components drugs that are already available in clinical trials for other diseases and their use in combination with a fat-free diet. More generally, the study opens up an entirely new approach for treating cancer that targets differences between the metabolism of tumours and that of healthy tissue.

Reference: Koundouros, et al. (2020) Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell DOI:https://doi.org/10.1016/j.cell.2020.05.053

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Targeting Cancers Dependence on Fat With Drugs and Diet Tactic - Technology Networks

We know. The words plant-based diet conjure nightmares of snacking on nothing but lettuce leaves and carrot sticks until the end of time. But it turns out this nutritious eating plan offers a lot of flexibility and delicious options that can boost your health and maybe even help you lose a few pounds. Here, your first week of eats on a plant-based diet meal plan, from breakfast to dessert.

RELATED: 15 Vegan Dinner Ideas Even Carnivores Will Love

Nope, its not the same thing as being vegan. In fact, you can still eat meat and animal products on a plant-based (or flexitarian, if you will) dietoccasionally. This diet is more of a concept than a strict set of rules, which means you have a lot of freedom regarding what you put on your plate. The idea is to consume meals that consist mostly of plant-based foods, plus modest amounts of fish, lean meat and dairy. The Mediterranean Diet is one example of a plant-based diet, as is veganism.

In general, youll want to bulk up on whole, minimally-processed foods, eat fish and lean meat occasionally (and red meat only sparingly) and exclude processed, refined foods. The more locally-sourced and organic, the better. While you can incorporate healthy fish, lean meat and poultry into your diet, the idea is to minimize your consumption overall (including eggs and dairy).

Here are a few foods to work into your day-to-day

Fruits and veggies

Legumes (like beans, lentils and peas), nuts and seeds

Whole grains (quinoa! farro! millet!)

Healthy carbs (like wild rice, sweet potatoes and fruit)

and a few to avoid often or altogether.

Refined and processed foods (wave goodbye to anything made with white flour, like regular pasta and white bread; refined grains like white rice; processed animal products like bacon, deli meat and sausage, and processed foods like potato chips, cereal bars and frozen dinners)

Red meat

Junk food

Added sugars and artificial sweeteners

Vegan junk food (steer clear of processed meat substitutes)

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Not sold yet? Maybe the many nutritional perks will sway you. First of all, cutting down on meat alone has a whole slew of pros. It could lower your risk for heart disease, stroke, high blood pressure, high cholesterol, cancer, diabetes and obesity, according to the American Heart Association. The only downside is that you may have to take a supplement, like vitamin B12, if you choose to exclude all animal products from your diet. Ask your doctor whats best.

A plant-based diet can also boost the immune system and reduce inflammation, according to the MD Anderson Cancer Center at The University of Texas website. Its also a surefire way to up your fiber intake and maintain a healthy weight. Evidence shows that the Mediterranean Diet can reduce your risk of heart disease, metabolic syndrome, diabetes and colon, breast and prostate cancers, as well as depression, according to the Harvard Medical School website. Plant-based diets are also great for brain health. Dairy, meat and fried foods high in saturated and trans fats can increase your risk for cognitive issues and Alzheimers. Avoiding these and replacing them with antioxidant- and vitamin-rich foods can have the opposite effect, says the Physicians Committee for Responsible Medicine. Did we mention a plant-based diet is also wonderful for the environment? Consuming fewer animal products saves water and reduces greenhouse gas emissions, says a 2019 study published in the journal Science.

Ready to get started? Heres one week of plant-based meals youll fall in love with.

A poached, runny egg makes everything better. It adds decadence (and protein) to a hearty mix of Brussels sprouts, arugula, sweet potatoes and a spicy harissa vinaigrette.

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Homemade sushi takes a lot of rolling, time and TLC. These muffin-tin gems come together fast without having to deal with messy raw fish. Stick with cucumbers, carrots and avocado or branch out to other veggies. The soy-sesame dressing will taste good on anything.

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Hate doing dishes? Youre preaching to the choir. Meet a 30-minute wonder in a sesame-soy sauce spiked with ginger, honey and red-pepper flakes.

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Its a good thing you had a light dinner, because this treat is seriously luxurious. Golden mylk, non-dairy milk mixed with ground turmeric, gets a whole new life in this coconut beauty made with vegan cream cheese.

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Old-fashioned oats turn creamy and flavorful after soaking in non-dairy milk and raw cocoa powder. Brighten up the mason jar with fresh fruit and coconut milk yogurt. Just skip the tablespoon of granulated sugar or swap it for honey.

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Dont look now, but youre the envy of the break room. You wont believe the creamy dressing is vegan and dairy-free. The secret? Raw cashews, olive oil and lemon juice. Well take ours with extra toasted hazelnuts, please.

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The juiciest veggie burger there ever was. Lentils and portobello mushrooms make for fiber-rich, hearty patties thatll fill you up just as much as beef would. Make it a lettuce wrap or swap in a keto bun.

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If youre like us, cookie dough only makes it into the oven *half* the time. And this version is vegan, paleo and gluten-free. Have it raw to your hearts content thanks to a mix of almond and coconut flours, pure maple syrup and vanilla extract.

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Blender, meet the best cruciferous veggie around. Cauliflower makes the sipper extra filling, so itll hold you over before lunchtime. Its also loaded with antioxidants (thanks, blueberries) and protein-rich, unsweetened almond butter.

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So, you went bar hopping and had two big pieces of birthday cake last weekend. Happens to the best of us. Enter the Crock-Pot cure-all thats made to cleanse your system. Its gluten-free and has lots of fresh veggies and herbs like spinach, snow peas, basil and mint.

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Have your pasta and eat it too, thanks to the most versatile gourd ever. Store-bought marinara (check the sugar content before you buy) is easy to spruce up with browned creminis, fresh thyme and rosemary and a sprinkle of nutritional yeast.

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Arent they gorgeous? Dont tell, but theyre also sugar-free. All their sweetness comes from pitted dates, cocoa powder and maple syrup.

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Spruce it up with diced bell peppers, spinach or sweet potatoes. Use brown or wild rice or substitute a broccoli or cauliflower crust instead. Were having ours with a side salad.

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Like takeout, only better. And healthier. Substitute beef for firm tofu, buckwheat flour and white chia seeds. If you really want to go the extra mile, peel your own cucumber and carrot ribbons.

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Gochujang is the spicy condiment you need in your life ASAP. The Korean fermented chili paste is the backbone of the honey-tamari sauce. Swap millet or farro in for white rice and voil.

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It turns out that if you freeze, puree and re-freeze cubed watermelon, it transforms into the most refreshing frozen dessert ever. Genius.

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Bring on the protein and healthy fats. Ditch the tortilla (and the carbs that come with it) and wrap smoked salmon and baby spinach in an egg white omelet instead. Fill it with avocado, roasted red peppers, asparagus and any other veggies you have on hand.

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Tuna who? You wont miss the fish once you taste this fresh take on a Hawaiian staple. Melon, cucumber and microgreens make it refreshing while peanuts and sesame seeds add the most important factor, crunch.

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The ultimate vegan comfort food. Its secret is a rich cashew cream sauce made with garlic, lemon and nutritional yeast. Want to make it gluten-free? Ditch the breadcrumb topping for double the toasted pine nuts.

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Raw peanut butter. Cocoa powder. Oats. Shredded coconut. These treats are as wholesome as they are dangerously snackable.

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We know, we love the sugary stuff too. But this combo of rolled oats and white and black sesame seeds will give you the crunch youre craving and the energy youre lacking. Try it with macadamia, almond or coconut milk.

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Your go-to Chinese restaurant order, reinvented. The best part is you only need six ingredients to make it, and most of them are conveniently pantry staples. Swap white rice for quinoa and dig in.

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Fire up the grill for a main thats equal parts healthy, simple and delicious. Not only are the skewers dippable, but the chicken is cooked in lemon-yogurt marinade to boot.

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Your gym buddies will be so proud. A handful of freshly-roasted nuts seasoned with rosemary, oregano, garlic powder and flaky salt will hold you over until morning.

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Three ingredients + 30 minutes = the easiest, filling on-the-go breakfast. If you dont have a food processor to combine the ingredients, use the blender instead.

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We hope you brought your appetite. Sink your teeth into layers of walnut taco "meat," avocado, salsa and cashew queso. Itll only take you 10 minutes to put together. Just be sure to use a low-carb tortilla made with ingredients like cassava or almond flour.

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Your favorite local Thai restaurant will miss you. Transform a lowly can of chickpeas into a half-hour delight with the help of red curry paste, fresh ginger, lime juice and coconut milk.

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Oh, banana. Is there anything you cant do? We think not, especially with sidekicks like dates and natural almond butter.

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RELATED: What Is the Ketogenic Diet? Heres What You Need to Know About Keto

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A Plant-Based Diet Meal Plan That Isn't All Salads and Oatmeal - Yahoo Lifestyle

The following editorial appeared in Thursday's Japan News-Yomiuri:

- - -

What kind of society should be created after overcoming a national crisis? It is difficult to say that such a substantial debate has taken place.

The ordinary Diet session has closed. Much time was spent on discussing measures against the novel coronavirus.

It is commendable that, taking into account the spread of infections, the ruling and major opposition parties worked together to pass the revised law on special measures against new strains of influenza, which became the basis for the government's declaration of a state of emergency, and approve the first and second supplementary budgets for fiscal 2020.

Many people cooperated with the requests to suspend business operations based on the special measures law. Although an explosive spread of infections could be contained, the impact on the economy has been severe. A budget that supports the livelihoods of the people is indispensable. It is important for the ruling and opposition parties to collaborate and take appropriate measures to deal with the crisis.

What is regrettable is that the old-fashioned confrontation between the ruling and opposition parties was noticable.

Up until the initial stage of the outbreak, opposition parties such as the Constitutional Democratic Party of Japan continued to grill Prime Minister Shinzo Abe on the issue of cherry blossom-viewing parties he organized. Since then, they have focused on the issues of subcontracting and outsourcing, criticizing the high cost of subcontracting administrative work such as for handling the cash subsidies to sustain companies that were included in the supplementary budgets.

The opposition cannot fulfill its role as responsible political parties if it puts priority on trying to damage the image of the Cabinet, rather than making constructive proposals.

The government's actions also raise questions. The bill to revise the Public Prosecutors Office Law to extend the mandatory retirement age of senior prosecutors was criticized by the public for threatening the prosecution's political neutrality. The feeling cannot be denied that the government then seemed to emphasize the size of the two supplementary budgets.

Isn't the prolonged running of the administration and the numerical strength of the ruling coalition holding the most seats in both chambers of the Diet leading to complacency in the government? The prime minister must carry out policies with a sense of tension.

Resuming companies' production activities even in midst of the coronavirus crisis; promoting digitization to give rise to measures against infectious diseases; taking the lead in international cooperation in the face of the U.S.-China confrontation, while solidifying security policies.

The ruling and opposition parties should delve into this pile of domestic and international issues. The government needs to respond positively to deliberations to be held while the Diet is out of session and explain its policies carefully.

Debates between the prime minister and opposition party leaders have not been held, and are continuing to lose meaning. Because each debate runs 45 minutes, opposition parties are demanding a budget committee meeting in which they can ask the prime minister questions for a lengthy time.

It has long been said that there is a growing burden on national politics as the prime minister and Cabinet members are tied up in the Diet. The ruling and opposition parties should seriously consider how to reinvigorate debates between party leaders and conduct Diet deliberations in times of crisis.

The House of Representatives Commission on the Constitution has only held one free debate. It is urged that a bill to revise the National Referendum Law to make the referendum more convenient be passed into law promptly and substantive discussions on the Constitution be held.

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Make active use of deliberations to be held while Diet is out of session - The Advocate

Image: iKnife cutting into a tumour. Credit: Jeroen Claus, Phospho Biomedical Animation

Its no secret that what we eat and drink can affect how certain medical treatments work.

You may have heard that we should avoid taking ibuprofen on an empty stomach and that grapefruit juice can interfere with medicines like statins and antihistamines.

There has been some evidence that diet could play an important role in responses to cancer treatments too.

For example, a few years ago, a group of researchers found that some cancer cells depend on the amino acidasparagine to grow and spread, and that limiting it in the diet could stop cancer from spreading in mice with breast cancer.

On top of that, a different team found that excess amounts of another amino acid histidine makes leukaemia cells in micemore sensitive to the chemotherapy drug methotrexate.

However, a new study published yesterday goes a step further and suggests that eating the right foods or in this case, avoiding the wrong ones can tweak a tumour's metabolism to make it vulnerable to treatment.

The study, carried out in mice and published in Cell, is one of the first to show that by avoiding certain foods we can make an otherwise useless treatment effective against cancer. In other words, its not just that diet makes the treatment more effective it ensures it works.

The study, led by Dr George Poulogiannisand his colleagues at the ICR, looks at a new class of drug known as cPLA2 inhibitors, which are used in clinical trials to treat inflammatory diseases like rheumatoid arthritis, psoriasis or dermatitis and are now being considered for trialling in cancer. The drug can target a key molecule known as cPLA2 and directly influence cancer's energy supply in mice.

Cancer cells use certain metabolic pathways to break down and obtain nutrients in ways that support their uncontrolled growth and spread. These pathways are often seen as a potential weakness that we can take advantage of. How? For example, by using a drug that blocks the pathway, which would deprive cancer cells of necessary nutrients.

Dr Poulogiannis, leader of the Signalling and Cancer Metabolism teambehind the research at the ICR said, It takes a lot for cancer cells to divide as often and spread as much as they do. They need lots of fuel.

In this new study, researchers found that cancers with mutations in the PI3K signalling pathway which has been linked to almost all human cancers rely on omega-6 fats to grow and spread.

The molecule cPLA2 in PI3K-mutant cancer cells releases arachidonic acid a type of omega-6 fatty acid that fuels the cancer and allows it to keep growing.

Dr Poulogiannis explained:

We believe that when cancers acquire mutations in genes that are part of the PI3K signalling pathway a key signalling pathway promoting many key functions such as cell survival and growth cancer cells are able to take advantage of this pathway and become more reliant on certain fat to sustain their rapid growth and proliferation.

Meat and dairy products are major sources of arachidonic acid. However, other omega-6 fatty acids such as linoleic acid, which can be found in sunflower oil, can also be converted by the body into arachidonic acid. This means that there are many different ways in which this cancer can obtain the fuel it needs to grow it can release it, or it can use the arachidonic acid from foods we consume.

Researchers used cPLA2 inhibitor drugs in mice to block the cPLA2 molecule from releasing arachidonic acid. However, because Western diets contain high amounts of omega-6 fats, researchers also had to feed mice a diet free from processed meat, dairy and processed vegetable oils. These are all foods high in omega-6 fatty acids, and by eliminating them from the diet, researchers enabled cPLA2 inhibitor drugs to work effectively against cancer in mice.

By getting rid of all the fat that sustains cancers growth through combining an experimental drug and diet changes we can defeat cancer in mice by targeting its metabolism, explained Dr Poulogiannis.

These findings open up the possibility of running new clinical trials where diet plays a key role and suggest that avoiding certain foods in combination with a targeted cancer drug could help attack tumours metabolism in future treatment strategies.

However, these findings do not mean that every cancer patient would benefit from a fat-free diet and they do not have any impact on existing, approved cancer treatments. After all, fat is one of the three main macronutrients that we need to survive, and completely cutting it out from our diet for no reason would not be healthy.

If the findings are successfully translated into humans through a clinical trial which is currently being planned, the approach could be relevant to many different cancer types with mutations in the PI3K pathway.

And Dr Poulogiannis believes the principles established in this study could mean that, when it comes to cancer, in the not-too-distant future, what we eat could have a much bigger role in how we treat.

He concludes: As we are able to unravel new evidence and understand more about the metabolism of cancer cells, using diet and nutrition to complement targeted drugs gets closer to becoming a reality.

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Science Talk - Can we target cancer's metabolism by combining new drugs with a fat-free diet? - The Institute of Cancer Research

By: Lifestyle Desk | New Delhi | Published: June 19, 2020 5:30:09 pm Are you including these important vitamins and minerals in your diet? (Photo: Getty)

While vitamins and minerals wont immediately turn you into a virus-fighting superhero but consuming them is extremely beneficial for your body and overall health. The current time has surely made us concerned about what we eat and how we can improve our diet. Ahead, take a look at these five important vitamins and minerals that make a world of difference when you consume them over time. They are known to increase immunity and fight infections.

READ| These 2-morning drinks will help you boost your immunity

1. Vitamin D: Vitamin D, which is found in eggs, fish, chicken and cod liver oil, is one of the most important vitamins and plays a crucial role in the activation of your immunity system whenever theres an exposure to pathogen-like viruses or bacteria. So its important to check your vitamin D levels and take the right supplements accordingly, says Dr Rohini Somnath Patil, MBBS, nutritionist.

However, the best source of this vitamin is when you are exposed to sunlight. The UV rays induce the body to manufacture Vitamin D from cholesterol present in your body. She mentions, The amount of sunlight needed ranges from about five to 20 minutes twice a week.

2. Vitamin C: Vitamin C is what makes your immune system strong. Make sure you consume Vitamin C rich foods like amla, lemon, kiwi, mangoes, oranges, etc. Vitamin C, also called ascorbic acid, is a potent anti-oxidant and co-factors many enzymes in our body. It holds a reputation as an immune system booster, says Dr Somnath.

READ| 5 superfoods to boost your immunity

3. Vitamin E: Vitamin E is a powerful antioxidant that helps your body fight off infections too. Almonds, peanuts, hazelnuts and sunflower seeds are rich sources of Vitamin E.

4. Magnesium and zinc: Along with vitamin D and C, magnesium and zinc are minerals which play a crucial role in carrying out the enzymatic processes in our body, mentions Dr Somnath. Magnesium helps in converting vitamin D into its active usable form and zinc has an anti-inflammatory action in our body. This protects our body and responds to immune damage. In fact, even chocolates contain a good dose of magnesium and release feel-good hormones.

5. Selenium: Selenium seems to have a powerful effect on the immune system, including the potential to slow the bodys over-active responses to certain aggressive forms of cancer, says the doctor. Make sure you get your dosage by consuming garlic, broccoli, sardines, tuna and barley.

READ| Turn to these traditional immunity boosters for better health

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Immunity boosters: Include these 5 vitamins and minerals in your diet - The Indian Express

The lazy keto diet is getting a lot of hype lately, possibly thanks to people looking to lose weight they put on during quarantine but not wanting to have to pull out a calculator every time they sit down to eat. Does it work though?

"I'm not a fan of any keto diet, but that doesn't mean it doesn't work for some people who are doing it with the guidance of a dietitian," nutritionist Bonnie Taub-Dix, RDN, told Good Housekeeping.

As nutritionist DJ Blatner, RDN, told the outlet, though, losing weight on the lazy keto diet has more to do with being careful of what you put into your body than anything else. "You can lose weight this way if the portions of protein are moderate and there are low-carb veggies included for nutrition, fiber, and fullness," she said. "But truthfully, once people start paying attention to what they're eating, no matter what type of diet they follow, they tend to lose weight compared to when they weren't paying attention at all."

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The truth about the lazy keto diet - The List

OhGod! My hair has started turning grey suddenly. We all have gone through this one dilemma, wherein we dont want our hair to get grey but at the same time its always been told that grey hair is linked to wisdom. Well, thats a tough decision whether to show your wisdom or your grey hair. But, its a fact of life that as we get older, greying of hair sets in. In fact, one-third of us go grey under the age of 30. The problem of premature greying of hair can be the result of different factors, key ones being genetic predisposition, hormonal rise and fall, addiction to smoke and stress and strain of modern lifestyle. The insufficient pigmentation of the hair follicle and the absence of melanin cause the scalp to have a mix of grey and white hair. Studies have also shown that grey hair is formed when a hair follicle starts building up too much hydrogen peroxide. Your hair follicle creates hydrogen peroxide naturally, but when the balance is disturbed or any malfunctioning happens, thats when we start seeing the occurrence of grey hair. While there is no cure for going grey (except by camouflaging it with hair colour), few tips will teach you how to stop grey hair at an early age to some extent.

Vitamins, minerals and nutritional deficiencies may also be one of the major causes of greying hair. In order for hair to look and grow healthy, and have that shine, hair needs proper amount of nutrients. Without a proper and balanced diet, our hair and skin begin to look haggard and weary. Grey hair and baldness are linked to stress because our response to anxiety is often stress-eating, and we deprive our body of the proper nutrition that it needs. Eating a balanced nutritious meal is necessary in order to maintain hair colour and to retain a healthy hair, besides having sufficient melanin.

Certain foods have been found to help in melanin production and prevent the greying of hair, and these can be incorporated into our diet to maintain the natural colour.

- A diet rich in copper can help your body naturally restore melanin in your hair. Some foods that contain a good amount of copper are almonds and cashews, mushrooms, lentils, potato, green leafy veggies, chickpeas, etc. Whole grains, lean meat and fish generally contain up to 50 percent of the required copper intake from a balanced diet. Tyrosine from food also helps in absorbing a good amount of copper from food, tyrosine can also be found in many natural sources like pumpkin seeds, lima beans and sesame seeds. Another good idea to improve your skins and body health is to eat nuts and legumes, peanuts, prunes and dried beans in your routine.

- Eating iron-rich food can add benefits to a copper-rich diet when attempting to restore melanin in your hair. Dark green vegetables such as spinach, fenugreek and kale or yellow fruits such as bananas and tomatoes, kidney beans, lentils, ragi etc are excellent sources of iron. Low iron levels are associated with early graying.

- Berries like strawberries, raspberries and cranberries, oranges, male, etc have an abundant amount of Vitamin C that promotes growth of healthy hair and also prevents premature greying.

- Dairy products like organic milk, curd and paneer are rich in Vitamin B, Vitamins B-6 and B12 that are vital for the production of red blood cells. This promotes oxygen and nutrients supply to your scalp.

- Refined and processed foods such as white flour, refined sugar and all products made from them, soft drinks, pastries, jams and jellies should be avoided. These unhealthy foods dont provide any nutrition and take away energy and cause wrinkles, unattractive skin, grey hair, and premature old age. Stay away from junk food as much as possible.

- Finally comes massaging your head withcoconut oil. It is one of the healthiest oils for your scalp. Not only does it prevent lice and dandruff, it promotes the regrowth of damaged or greying hair. Application of coconut oil on scalp and also on hair nourishes hair and consequently prevents premature greying of hair, plus it also conditions hair better than any other synthetic or chemical products available in the market. Application of warm coconut oil makes the hair sparkling, soft, and smooth and in the long run it also slows down the growth of grey hair. By massaging this oil into the hair roots and scalp, natural melanin production can be boosted. You can also combine this oil with lemon juice or Indian gooseberry (amla) for an additional melanin boost to your scalp. Curry leaves can also be boiled in coconut oil, this is a popular home remedy and an excellent hair tonic to stimulate hair growth and increase hair pigmentation.

- As I mentioned earlier, grey hair can also be caused by hydrogen peroxide built up. This can be successfully neutralised by the catalase enzyme. And where can we find that stuff? Dont worry, its in our humble onion. The remedy is simple just mix one part onion juice with one part lemon juice. Massage this into your scalp daily, and then wash off. You will definitely get the results.

These treatments are very effective at an early age to prevent greying and to maintain good scalp health, so follow it and get healthy hair. Above all, follow a youthful and positive attitude. The latter is a great buffer against lifes stresses, including stress-related greying of hair.

Chief Nutrition Officer, Luke CoutinhoHolistic HealingSystems. Thewriter is a clinicalnutritionistwith a focus onhealthy lifestylechoices.

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Here's a guide to a healthy diet to prevent greying hair - Indulgexpress

In recent times, there has been a growing trend among YouTube content creators to mirror the daily diets and training regimes of celebrities and athletes.

In rare instances, these can just be a bit of fun. However, when you are talking about an athlete like Mike Tyson, the task is anything but enjoyable - as YouTube uploader Will Tennyson found out.

Having recently teased a comeback after getting back into shape, 53-year-old Tyson takes his training very seriously and keeps a relentless schedule when it comes to both eating and training.

The first hurdle that Tennyson had to deal with when attempting to walk in "Iron" Mike's shoes was getting up at 4am - Tyson's preferred time to start his day with a jog of up to five miles! Tennyson manages a distance of four miles, before returning to bed.

The physical training continues later in the day in the shape of 10 rounds of sparring, with a minimal break in between rounds. Tennyson admits that the prospect of so many rounds is a daunting one.

"I feel like a lot of people underestimate just how hard boxing is on your cardiovascular system because you don't see a lot of running... But you're exerting so much force with the punches, that after ten rounds of 2 minutes I'm gonna be wiped."

There is little time to recover, though, as Tennyson then sets about starting Tyson's daily calisthenic workout. Comprising 2,000 squats, as well as 500 reps each of push-ups, neck crunches, tricep extensions and shrugs with a 30kg weight, Tyson's training programme is not for the faint of heart. Tennyson does pass on doing Tyson's usual neck bridges, though, citing safety concerns.

After completing just a small portion of the overall workout, Tennyson is already feeling the pace, but recognises that it is a necessary sacrifice for a top athlete.

"That was 1 round, and I'm already curled up in a ball," he admits. "This is insane, but if you want to be the best in your sport, you got to get outside of your comfort zone. Only the great ones do this stuff, and he does this 5 times a week."

The exercise portion of Tennyson's day is rounded off with more sparring andcalisthenics, followed by nearly an hour on an exercise bike.

You might think that the eating side of this would be significantly easier than the training side. However, Tennyson confirms that this is not the case.

"After looking at his diet, he doesn't have a variety of foods. Every meal is a carb and a protein. And it doesn't seem like he's not eating for enjoyment, he's just eating for fuel, and that's a true athlete to me," states Tennyson.

Tyson's breakfast is oatmeal, milk and vitamins. Lunch is not much more exciting either, consisting of a chicken breast, a small portion of rice and some orange juice. The final meal of the day is a sirloin steak with pasta. Everything is very bland according to Tennyson, with even Tyson's snack being unexciting - a monstrous serving of six bananas and a protein shake!

"It seems a little bit overkill, but I definitely need the carbs right now," admits a depleted Tennyson.

Having previously mirrored the daily routines of the likes of Mark Wahlberg, Tennyson is no stranger to these sorts of challenges. It seems, though, that taking on a day in the life of Mike Tyson was Tennyson's hardest test yet!

"I'm very sore. My neck is super stiff, and I know I'm going to be feeling it for a few days after this," reveals Tennyson at the end of the day. This challenge is probably not one to try at home!

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YouTube creator takes on Mike Tyson's punishing daily workout and diet schedule - GIVEMESPORT

The ruling camps decision to close the regular Diet session on June 17 as scheduled without extending the term amid continued concerns about the new coronavirus reflects the Abe administrations desire to avoid further opposition attacks on its policy failures.

Prime Minister Shinzo Abe and his top aides were clearly unwilling to continue facing questions at the Diet about their responses to the outbreak and other issues. Abe put a higher priority on rebuilding his troubled leadership than on fulfilling his responsibility to explain his policy decisions and actions to the people.

The government claims that the massive reserve fund included in the second supplementary budget for this fiscal year will allow it to make swift policy responses to any unpredictable problems.

Given the lack of transparency in the governments plan to contract out the administrative work for a program to help cash-strapped businesses survive the current crisis, however, it is obvious that the administrations policy actions need to be monitored and checked regularly by the Diet.

NO PROGRESS TOWARD ADDRESSING SCANDALS

There was no time for the Diet to question the governments decision to halt the plan to introduce a U.S.-made Aegis Ashore missile defense system, announced abruptly near the end of the Diet session. This underscored afresh the Abe administrations inveterate tendency to avoid debate on sensitive policy issues and disregard the importance of the role of the Diet.

Before the nation became preoccupied with responding to the coronavirus outbreak, the focus of the regular Diet session was on a series of scandals that had hit the administration.

They include allegations that Abe abused the annual cherry blossom viewing parties he hosted for his personal gain and a bribery scandal concerning Abes policy initiative to introduce casino-centered integrated resorts into Japan. The casino scandal resulted in the arrest and indictment of Lower House lawmaker Tsukasa Akimoto, who was appointed by Abe as senior vice minister at the Cabinet Office in charge of IR projects, for allegedly receiving bribes from a Chinese company seeking to operate a casino in Japan.

The administration has also been struck by an election law scandal involving a top aide to rookie Upper House member Anri Kawai and her husband, former Justice Minister Katsuyuki Kawai, and allegations concerning a dubious sale of state-owned land to Moritomo Gakuen, a private school operator linked to Abes wife, Akie, which drove a Finance Ministry official into suicide.

Notes and the will left behind by the official were later released.

There has been no notable progress toward clarifying the allegations, raising serious doubt over the credibility of the administration. But the Diet session became dominated by challenges posed by the public health crisis.

While dealing with an outbreak of such an unknown virus inevitably involves a trial-and-error process, many Japanese seem to view the series of policy decisions made by the Abe administration in handling the crisis as a chain of delayed responses to the changing situation.

Many political pundits say the administration was slow to take actions to contain the infection partly because Abe was concerned that strong measures could have serious repercussions on Chinese President Xi Jinpings scheduled--and later canceled--state visit to Japan in the spring.

The administration was also concerned about the negative impacts on the 2020 Tokyo Olympics and Paralympics, which have been postponed to next year, as well as on local economies heavily dependent on foreign tourists visiting Japan.

It is quite doubtful whether the administration has made detailed records about its policy responses to the pandemic that are vital for later reviews and assessments of the actions.

Despite its characterization of the outbreak as a historic emergency situation, the Abe administration has failed to keep formal minutes of the meetings of the expert panel advising the government on its responses to the COVID-19 outbreak.

Records of proceedings at special meetings of the prime minister and key Cabinet members responsible for the governments responses to the crisis, where they effectively make related policy decisions, do not include these top policymakers remarks. These facts speak volumes about the administrations lack of commitment to solid management of official documents and adequate information disclosure.

CHANGE OF MIND FORCED BY PUBLIC PRESSURE

Unlike lockdowns imposed in many other countries, the restrictions on outings and business operations in Japan are based only on requests from the government and lack legal enforceability supported by punishment for violations. Public trust in the administration is crucial for the success of this unique approach, which depends on voluntary efforts by a broad range of individual citizens.

But Abes efforts to communicate his policies to the public have been insufficient, and his habit of reading prepared texts instead of speaking in his own words has not helped get his messages out to the public.

Abes initiatives included distributing face masks to all households amid a serious shortage and sharing a video of himself lounging on a sofa with his dog, along with a message telling people to stay at home, in response to popular musician Gen Hoshino, who uploaded a video of himself singing about dancing indoors and invited people to reciprocate.

Both of Abe's actions,based on advice from a small number of close aides, only impressed upon the public how divorced he is from the peoples feelings.

While the administrations long-criticized evil tendencies hobbled its effective handling of the pandemic, there have been unusual cases of the administration being forced to drop policy initiatives that it previously would have forcibly pushed through.

One is its decision to give up enacting legislation to give the government the discretion to extend the legal retirement ages of top public prosecutors.

The legislative initiative provoked a wave of protests in social media and prompted a group of retired top prosecutors led by former Prosecutor-General Kunihiro Matsuo to submit a position paper expressing opposition to the revision to the Justice Ministry.

The controversial bill to revise the Public Prosecutors Office Law was discarded on June 17 as the Diet session ended. If the administration intends to make sincere responses to the public opinion, it should give up on this dubious initiative altogether.

Another notable change in a policy decision concerns the centerpiece of the governments package of measures to ease the economic impacts of the outbreak.

It retracted the Cabinet decision to provide 300,000 yen ($2,800) to families suffering from falling incomes, which did not go down well with the public, and then, in response to a strong request from Komeito, the junior coalition partner of the ruling Liberal Democratic Party, switched to handing out 100,000 yen in cash to every resident.

The Abe administration has lost much of its once strong political momentum, which was supported by his dominant political power and high approval ratings. But it is too early to predict that his weakened power base will lead him to adopt a humbler approach to governing the nation.

POLICY DECISIONS SHOULD NOT BE BASED ON MISPLACED PRIORITIES

Abe is in his eighth year in office since he returned to power, with a little more than a year left until the end of his term as the LDP president.

After leading the ruling coalition to a major victory in the Upper House election last year, Abe tried to accelerate his long-cherished ambition to amend the Constitution. But no wave of public support for his efforts emerged.

The Commissions on the Constitution of both houses did nothing to promote the cause during the latest Diet session but hold just one session of free discussions.

Abes efforts to move ahead Japans negotiations with Russia over a bilateral peace treaty by leveraging his personal relationship with Russian President Vladimir Putin have produced no progress.

Whether the Tokyo Olympics will be held next year will depend on an end to the pandemic.

Abe should not be criticized for trying to leave some legacies of his long rule. What he should focus on at the moment as this nations leader, however, is the colossal challenge of keeping the virus under control while resuscitating the moribund economy.

The remaining restrictions on cross-prefecture movements and operations of certain types of entertainment facilities, such as bars and clubs that provide companionship, are to be lifted on June 19.

With the threats of a possible second and third wave of infections looming on the horizon, the Abe administration needs to put the top policy priority on efforts to safeguard peoples lives and livelihoods and secure the health of the nations social and economic systems.

The ruling and opposition camps have agreed to hold weekly special committee sessions in both houses even while the Diet as a whole is in recess.

If Abe wants to regain the public's trust, he needs to answer questions at these sessions to clarify all the allegations against his administration.

--The Asahi Shimbun, June 18

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EDITORIAL: Diet session ends with Abe failing to address many policy failures : The Asahi Shimbun - Asahi Shimbun

GoPro image of a great white shark taken off the coast at Evans Head, NSW. Photo: Richard Grainger

Dr Vic Peddemorsa co-author from the NSW Department of Primary Industries (Fisheries), said: We discovered that although mid-water fish, especially eastern Australian salmon, were the predominant prey for juvenile white sharks in NSW, stomach contents highlighted that these sharks also feed at or near the seabed.

Mr Grainger said: This evidence matches data we have from tagging white sharks that shows them spending a lot of time many metres below the surface.

The study examined the stomach contents of 40 juvenile white sharks (Carcharodon carcharias) caught in theNSW Shark Meshing Program. The scientists compared this with published data elsewhere in the world, mainly South Africa, to establish a nutritional framework for the species.

Understanding the nutritional goals of these cryptic predators and how these relate to migration patterns will give insights into what drives human-shark conflict and how we can best protect this species, saidDr Gabriel Machovsky-Capuska, an adjunct Senior Research Fellow at the Charles Perkins Centre and a co-author of the study.

Mr Grainger said: White sharks have a varied diet. As well as east Australian salmon, we found evidence of other bony fish including eels, whiting, mullet and wrasses. We found that rays were also an important dietary component, including small bottom-dwelling stingrays and electric rays.

Eagle rays are also hunted, although this can be difficult for the sharks given how fast the rays can swim.

The study found that based on abundance, the sharks diet relied mostly on:

The remainder was unidentified fish or less abundant prey. Mr Grainger said that marine mammals, other sharks and cephalopods (squid and cuttlefish) were eaten less frequently.

The hunting of bigger prey, including other sharks and marine mammals such as dolphin, is not likely to happen until the sharks reach about 2.2 metres in length, Mr Grainger said.

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Great white shark diet surprises scientists - News - The University of Sydney

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