Search Weight Loss Topics: |
My food revolution: how I learned to love a gluten-free diet – The Guardian
How to have a healthy gut
After years of pain, the diagnosis of coeliac disease was a crucial turning point for Lizzy Davies. She explains the changes it forced her to make and how she learned to love food once again
Sat 18 Mar 2023 09.00 EDT
It starts with a strange tingling on my tongue as I get on the tube in central London. About five minutes later, I start to wonder if I might feel a little faint (or is it just really, really hot down here?). After 15, I know: Im going to vomit the entire contents of my stomach into a bag full of orchard fruits from my friends dads garden. Have some apples and pears from Normandy, shed said, charmingly, just an hour or two earlier, as we sat down for my 40th birthday afternoon tea. Little did she know the horror that was to be unleashed on that inoffensive little tote.
A few minutes later, as I stand at the side of the road in north-east London, puking into a bin in broad daylight, it occurs to me that people must think Im drunk. But alcohol has nothing to do with my current predicament. You can blame that entirely on the scones. Or perhaps the sandwiches. I certainly have my suspicions about the dainty little tart whose pastry tasted so good, so buttery, so, well, not gluten-free, that I double checked with the waitress. But thats the thing about being coeliac: youre often not quite sure what the culprit was. You just know theres been a crime and your poor, long-suffering gut is the victim.
It was towards the end of a two-year, pasta-filled stint in Italy as the Guardians Rome correspondent that I realised something was seriously wrong with what my mother would term my insides. I remember calling her after a trip to Venice (I think it had been to cover George Clooneys showstopper of a wedding now theres a nice contrast for you), convinced that the agonising guttural cramps and debilitating fatigue I was experiencing were due to Giardia, a tiny parasite that spreads diarrhoeal disease. But it says on the internet that you generally only get Giardia from travelling to far-flung places where theres no clean water, my mum said, or something to that effect, gently, and doubtfully. Ive been to Venice! I wailed, insistent that the pungent waters of the Grand Canal had left me bedridden. I wasnt fooling either of us.
Several months later after weeks of mysterious and relentlessly unpleasant gastrointestinal symptoms I finally went to the GP in Britain. I had visited a doctor during a grim holiday in the US when I was largely unable to leave the apartment but Id been prescribed antibiotics, which had done nothing, and stung for several hundred dollars, so I wasnt feeling optimistic. But I was desperate: my illness had come to dominate my life. I had lost a huge amount of weight. I was so weak I ended up leaving Italy without telling many people because I simply didnt have the energy physical or mental to call them, let alone meet. (If youre one of them, sorry.)
But this doctor was great, and it was only in retrospect that I realised quite how unusual she was. Upon hearing my symptoms she immediately referred me for a blood test, and within days she called me at work to tell me the news: my bloods had shown I was severely anaemic and I had coeliac disease. What, I remember saying, that thing with gluten? No way! When I was really sick the only thing I could stomach eating were those little salty wheat crackers; I would eat packets and packets of them Oh. The cogs of my brain started, slowly, to turn.
I got lucky with my doctor. Plenty of people, Ive since learned, struggle for years with all the symptoms of coeliac disease bloating, diarrhoea, vomiting, heartburn, brain fog: a veritable smrgsbord of delights without ever being diagnosed. As it was, I was told to continue eating gluten until I could have the biopsy that would confirm my diagnosis by showing damage to my small intestine. And then? What was the treatment, I wanted to know? When could I go back to the crackers?
The answer was short, and blunt: never. The only way for someone with coeliac disease an autoimmune condition that, if undiagnosed, can lead to the slow damage of organs and bowel cancer is to give up gluten for ever. Now, given that this is a protein that is found in wheat, rye, barley and, due to high levels of cross contamination, oats that can feel like a mammoth challenge. It means, obviously, no (normal) scones, no cakes, no sandwiches. It also means no beer, no Colmans mustard, no soy sauce. Do not sample that street food, do not take a punt on that new chippy, do not linger beside the festive buffet.
It is the end of one era of your life, and the beginning of another. Of course, theres a sense of loss. But by that point many people are so glad to finally have an answer to their troubles that they are happy to start afresh. I certainly was. It was worrying enough to hear about my anaemia, which was so bad my GP said I would in previous years have been hospitalised. (These days industrial-strength iron tablets did the trick.) On top of that a bone scan showed I had osteopenia, the precursor to osteoporosis. I was in my early 30s. The consultant said Id probably had coeliac disease for about a decade without knowing it.
I was desperate, therefore, to feel healthy and energetic again although I did wonder if maybe it had been so long I had forgotten how that felt. I threw myself in to decoding this new and unfamiliar world: one of scanning each label on every item of food to see if I could eat it or not (bewildering, to begin with, but now I do it without even thinking about it, my brain like a barcode-reader). Shopping took a lot longer. Eating in restaurants was a minefield. (I am lucky that my partner is a fantastic cook I am hopeless.)
Going to friends houses was excruciating. It is incredibly difficult, especially if youre a chronic people pleaser like me, to say to someone who has tried their hardest to cook something gluten-free that you still cant have it because theyve put in one forbidden ingredient or used the same pan for normal and GF pasta or sprinkled some soy sauce on at the last moment or, well, the list of unfortunate potential errors is, sadly, endless. Its best for everyone if I just bring my own. I do the same when I travel abroad for work, which is on the one hand soul-destroying in countries like Lebanon, with some of the most delicious cuisine known to man, but frankly reporting is easier if youre not also trying to vomit into your handbag and Id rather not take the risk. Having said that, the best gluten-free bread Ive ever had, bar none, was in Bethlehem.
If youre reading this because you have been recently diagnosed, please, dont worry. You will feel healthy again! You will enjoy food again! It will be a bit different, but after a few years you wont even notice. It becomes normal. Theres a huge variety of gluten-free food in the shops, the kind that coeliacs couldnt have dreamed of 30 years ago. The M&S Made Without Wheat range is a personal favourite, though its not cheap, and I have recently discovered Leighs gluten-free bakery, which makes mouthwateringly good focaccia and delivers coeliac-friendly doughnuts to my door: the dream! Oh, and I know I said no soy sauce but actually tamari is just as good.
Though it may not feel like it to begin with, you can still eat a huge range of food on a gluten-free diet: fruit, vegetables, pulses, potatoes, rice, and, depending on your diet, dairy, meat and fish. If anything, my diagnosis has made us cook more from scratch and more healthily as a family. Our kids are educated in the details of the gastrointestinal tract: the five-year-old has been known to do a highly dramatic full-body imitation of my small intestines villi collapsing, vanquished by the deadly enemy: wheat. I have found the best gluten-free bakery in Paris, and mastered the art of a GF sticky toffee pudding.
One day, perhaps, I may even brave an afternoon tea again. But not any time soon; Im still having flashbacks to that tote bag.
{{topLeft}}
{{bottomLeft}}
{{topRight}}
{{bottomRight}}
{{.}}
View post:
My food revolution: how I learned to love a gluten-free diet - The Guardian
What is the healthiest vegetable? There isn’t one ‘best’, but these are great nutrient-dense options. – USA TODAY
Only one in 10 adults consume the recommended daily vegetable intake, the Centers for Disease Control and Prevention says. And while a regular intake of vegetables is crucial to a healthy diet, food insecurity in 27% of American households shows there are significant barriers to accessing vegetables to cook at home.
If youre looking to increase your daily vegetable intake, look no further. Heres a guide to the mostnutrient-dense veggies,plus tips for incorporating more fresh and frozen greens into your diet.
When it comes to vegetables, registered dietitian and nutritionist Danielle Crumble Smith says "dont discriminate."
She says there isnt just one "healthiest" vegetable, though there are some particularly nutrient-dense options to keep an eye out for. Here's a look:
"Dark leafy greens get a lot of attention and for good reason," she says. "They have vitamin K, theyre rich in calcium and a host of different antioxidants."
Most people think of spinach when they hear "leafy greens,"but Crumble Smith recommends widening your palateand trying chard, collard greens, mustard greens or beet greens.
What is the healthiest fruit?: This one is high in antioxidants and has cognitive and cardiovascular benefits.
Cruciferous vegetables make another great addition to one's diet. Those include broccoli, cauliflower, Brussels sprouts, asparagus, cabbage andbok choy, among others.
Cruciferous vegetables contain fiber, phytonutrients to prevent cellular damage and indole-3-carbinol, a compound shown to decrease estrogen dominance and reduce the risks of estrogen-related cancers as well as colon cancer, Crumble Smith says.
But there are some specifics to look out for when it comes to vegetables and your specific dietary needs. (As always, consult your physician if you have specific questions related to your diet.)
Spinach, beet greens and chard contain oxalates, which can bind to minerals like calcium and inhibit their absorption. For this reason, Crumble Smith recommends that people who are dairy-free should look outside of leafy greens to satisfy calcium needs.
People who have had oxalate kidney stones and want to prevent future recurrence may also want to be wary of vegetables with high oxalate content, though she says drinking enough water every day can also decrease the risk.
Crumble Smith says these vegetables are still good sources of vitamin K, lutein and vitamin C, so its not a reason to avoid them, or any other vegetable, completely.
Starch vegetables, which include potatoes, corn, squash, peas and carrots and others, often get a bad rap because of their carbohydrate content.
"Those have a host of nutrients, but also do provide carbohydrates and they can elevate blood sugar levels,"Crumble Smith says. "People who have diabetes or any sort of insulin resistance and people who have weight loss goals, over-consuming carbohydrates could interfere with their weight loss."
But that doesnt mean you should avoid starchy vegetables theyre an excellent source of fiber and potassium, which can help control high blood pressure.
Crumble Smith says starch vegetables in one's diet can fuel runners for longer distances and assist with recovery.
How to eat less ultra-processed foods: Avoid health risks with these new practices
What foods are high in iron?: Here are some healthy options to add to your diet
The U.S. Department of Agriculture recommends 2 to 3 cups of vegetables per day for adult women and 3 to 4 cups for adult men. Here are a few examples of what counts as "one cup" of vegetables:
Tossing extra vegetables into soups, stews and sandwiches is also a good way to reach your recommended daily intake. But if that doesnt sound appetizing, try these tips from Crumble Smith:
Your instinct may be to look for fresh vegetables rather than stocking your freezer with frozen ones. But unless youre buying them locally and know exactly how long theyve been sitting out since being harvested, Crumble Smith says frozen veggies actually have more to offer.
"Theyre flash frozen at their peak stage of ripeness when all those nutrients are there and preserved,"she says. "Frozen veggies are a great, very nutrient-dense option and theyre also really good for people who forget there are veggies in the fridge that might be going bad before they get to it."
Where are all the eggs?: Try these eggless recipes amidshortage, rising prices
Just Curious?: We're answering your everyday questions
Original post:
What is the healthiest vegetable? There isn't one 'best', but these are great nutrient-dense options. - USA TODAY
An inflammatory diet could be hurting your sleep. What foods to avoid (and which to indulge in) – Fortune
Having trouble falling asleep? Staying asleep? Getting good sleep?
Your diet could be to blame.
A new study from the University of South Carolina, published recently in the journal Nutrients, found that those who ate more inflammatory foods slept worse than those who ate less of them.
Dr. Michael Wirthone of the studys lead authors, and an assistant professor of epidemiology and biostatistics at the universitys Arnold School of Public Healthtells Fortune hes looked at the role of inflammatory diets in a number of different groups: police officers, pregnant women, and men in general.
All such studies came to the same conclusion: When people move toward a more anti-inflammatory diet, they sleep better.
They dont necessarily sleep longer, Wirth cautions. But they spend more time in bed asleep, without waking up. And they get more quality sleep. It improves their sleep efficiency, he notes.
Why? High levels of inflammatory markers like interleukin 6 and tumor necrosis factor inhibit the natural rhythm of the sleep-wake cycle, Wirth says. If someones diet frequently contains inflammatory foods, you lose that natural rhythm.
His advice to those who want to improve their sleep via diet: Dont start drastic.
One thing I try not to do is say, Hey, take your diet and completely change everything about it, he says, adding that Americans, in particular, dont respond well to such demands on their freedom.
His suggestion instead: Start by adding just a couple of anti-inflammatory foods to your diet regularly.
Even smaller changes can make a difference, like adding spices, herbs, onions, and/or garlic to the dishes you had already planned to make. Spices and herbs in particular are some of the most anti-inflammatory foods on this planet, Wirth saysan effect opposite of what you might expect, given their zest and heat.
If you find yourself sleeping better and are looking to take things a step further, cut down on animal protein and foods that come in a box, Wirth recommends.
He references the notion of shopping on the outside of the store. If you stick to the parameters, youll encounter whats freshfruits, veggies, protein, dairy, and the likeand avoid processed foods chock full of unhealthy preservatives and additives.
If that seems too tall of an order, focus on snacks first, Wirth suggests, as theyre typically the main source of processed foods in a diet.
Other good foods to limit due to their inflammatory status: fried foods like fried chicken, and those laden with oil, like many pizzas.
Eliminating even one or two inflammatory foods from your diet will put your body on a path toward healing, Wirth advises. And you can expect to be paid in benefits both short- and long-term.
After two, three, four nights of really good sleep, youre going to start to see changes in alertness during the day, the ability to think on your feet, physically not being as tired, he says.
Further out, expect a reduction in risk for obesity, heart disease, cancer, and other maladies.
When inflammation disrupts the bodys natural circadian rhythm, more than just sleep is affected, Wirth cautions. So is everything from your bodys ability to fight off infection and digest your food, to prevent insulin resistance.
The good news: Small, positive diet choices can begin moving the needle backquickly.
Adds Wirth: Youre going to feel better, be able to think better, do things physically better.
See the original post:
An inflammatory diet could be hurting your sleep. What foods to avoid (and which to indulge in) - Fortune
What happens when you grow up on the Mediterranean diet? She … – American Heart Association News
Naima Moustaid-Moussa (left) and her husband, Hanna Moussa, with food they cooked for international students at Texas Tech University. (Photo courtesy of Naima Moustaid-Moussa)
You can find health advice almost anywhere these days. But finding reliable information and figuring out how to apply it can be overwhelming.
So to help sort things out, American Heart Association News is launching "The Experts Say" as a new series where specialists tell us how they apply what they've learned to their own lives.
Today's expert is Naima Moustaid-Moussa, Horn Distinguished Professor of Nutritional Sciences and director of the Obesity Research Institute at Texas Tech University in Lubbock. She talked about how her eating habits are shaped both by the flavorful foods she ate growing up and what she's learned as a scientist. Here are highlights from the conversation.
Is there a guiding principle behind what you eat?
There are two. One is culturally guided, and one is science-based.
I grew up in Morocco. We mostly ate fresh meats, fruits and vegetables. We'd go to the market and buy the fish. We always cooked with olive oil or argan oil. So I grew up eating what we call the Mediterranean diet. We didn't know it was called a Mediterranean diet at that time. It was just what we ate.
As I grew up, went to grad school in France and came to the U.S., I got more into science. And what we see is that if you're eating your fiber, your fruits, your vegetables, it will provide much of the vitamins and minerals that help promote a healthy lifestyle.
For example, I've always liked fish, even at a younger age, but knowing data on fish oil, I eat even more, and I made sure when my children were at home to provide diets containing fish and other nutrient-dense foods.
Especially prior to the pandemic, my husband and I have had parties for our lab and cook things we study. I do actually eat the foods we study. For example, I didn't eat tart cherries specifically when I was in Morocco, but I've been eating them more and looking for them when I shop since we've been doing research on them.
Tell us more about how where you grew up influences your food choices.
My parents did not have any education at all, but they have always insisted not only on us getting education, but also eating healthy. It was important to them that we ate fresh fruits and vegetables, and to not overeat. My father is 100 years old now. While he may have inherited some great genes, he was also physically active most of his life and was eating balanced diets.
The only canned food I had growing up was tomato paste. I'm not saying that all canned food is bad; as some canned veggies or fruits are great alternative for someone who cannot access readily fresh produce. But that's the only thing that was canned.
In most of our cooking we use ginger, coriander, parsley and saffron. In some, we use cumin as well. When you use this mixture, you don't need a lot of salt because you really have flavor and good taste.
Walk us through what you might eat in a typical day.
I'm a very-early-morning person. I wake up at 5 o'clock, sometimes earlier, and may have coffee and get a workout done before breakfast. Sometimes, I have breakfast first.
Breakfast is often a mix of Moroccan and Syrian foods (my husband is Syrian.) We use a spice mix called za'atar. It's basically a mix of thyme and some other herbs and roasted sesame seeds. We use that with olive oil and also fat-free Greek yogurt (we call it labneh) as a dip. We eat it with whole-wheat pita bread. And I would have on the side some olives not too many, because they can be very salty. And then we have some cucumbers, some tomatoes and sometimes arugula or lettuce with it. Sometimes we would add a couple of eggs as well, cooked plain or scrambled in olive oil and spices.
I usually have a light lunch, like a salad. I bring snacks with me. I like dried mangoes, dried figs, or fresh fruits, or dried vegetables. Sometimes, I take a walk around campus and grab a light lunch close by if I did not bring it from home.
My children are grown now and in college or working, but we used to have a family dinner with the kids. We would always have protein fish is a common one, or lean beef or chicken. We would have rice or bread, and a salad and other cooked veggies on the side.
My husband is an exceptional cook and would do most of the cooking. As an example of a side dish, he would brush okra with olive oil and put it in an air fryer, then make fresh tomato sauce and mix it together with spices to add flavor. He also makes Syrian salads such as tabbouleh.
Or we would have couscous, especially for parties. It is called "seven vegetable dish," made with eggplant, turnip, Brussel sprouts, carrots, tomatoes, squash and yellow and green zucchini, mixed with chickpeas. It's made in a double boiler. You have the vegetables in the bottom part, with the spices mentioned above plus fresh parsley and coriander, and tomato sauce. Then at the top, you steam the couscous over the vegetables. Sometimes we cook it with lamb or beef in addition to the veggies.
One dish I love is roasted saffron chicken. We use a lot of saffron, and saffron has a lot of health benefits.
I like desserts too, but mostly for the weekend or special occasions. We make or buy baklava filled with pistachios, walnuts or dates.
If someone wants to change their eating habits, what do you recommend?
Sometimes it's just portion size. That is a good place to start. Because even if you're eating healthy, but eating too much of everything, that's not good either.
Reduce a little at a time. Maybe rather than using big plates that we all use in the U.S., start with smaller plates. Then you can fit less food. One can also substitute cooking methods. Like instead of frying, you can bake or use an air fryer with small amounts of olive oil. This significantly reduces the fat calories.
What's your most essential nutrition advice?
A person has to really be convinced they want to make changes and understand why this is good for their own health. If they're not ready for it, no matter what you tell them, it's not going to happen. Family and friends' support is also important.
Once you are convinced that you want to change the way you eat, then it is important to set realistic goals and do it in small steps, while seeking both medical and dietitian advice, as every person may have different needs.
Original post:
What happens when you grow up on the Mediterranean diet? She ... - American Heart Association News
Cardiometabolic health, diet and the gut microbiome: a meta-omics … – Nature.com
Mathers, C. D. & Loncar, D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 3, e442 (2006).
Article PubMed PubMed Central Google Scholar
National Academies of Sciences, Engineering, and Medicine et al. in High and Rising Mortality Rates Among Working-Age Adults Ch. 9 (National Academies Press, 2021).
Jagannathan, R., Patel, S. A., Ali, M. K. & Narayan, K. M. V. Global updates on cardiovascular disease mortality trends and attribution of traditional risk factors. Curr. Diab. Rep. 19, 44 (2019).
Article PubMed Google Scholar
Korecka, A. & Arulampalam, V. The gut microbiome: scourge, sentinel or spectator? J. Oral Microbiol. 4, https://doi.org/10.3402/jom.v4i0.9367 (2012).
Tang, W. H. W. & Hazen, S. L. The gut microbiome and its role in cardiovascular diseases. Circulation 135, 10081010 (2017).
Article PubMed Google Scholar
Menni, C. et al. Gut microbial diversity is associated with lower arterial stiffness in women. Eur. Heart J. 39, 23902397 (2018).
Article CAS PubMed PubMed Central Google Scholar
Nogal, A., Valdes, A. M. & Menni, C. The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. Gut Microbes 13, 124 (2021).
Article PubMed Google Scholar
Hansen, T. H., Gbel, R. J., Hansen, T. & Pedersen, O. The gut microbiome in cardio-metabolic health. Genome Med. 7, 33 (2015).
Article PubMed PubMed Central Google Scholar
Jardon, K. M., Canfora, E. E., Goossens, G. H. & Blaak, E. E. Dietary macronutrients and the gut microbiome: a precision nutrition approach to improve cardiometabolic health. Gut 71, 12141226 (2022).
Article PubMed Google Scholar
Wan, Y. et al. Contribution of diet to gut microbiota and related host cardiometabolic health: dietgut interaction in human health. Gut Microbes 11, 603609 (2020).
Article PubMed PubMed Central Google Scholar
Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99103 (2013).
Article CAS PubMed Google Scholar
Talmor-Barkan, Y. et al. Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Nat. Med. 28, 295302 (2022).
Article CAS PubMed Google Scholar
Sumida, K. et al. Circulating microbiota in cardiometabolic disease. Front. Cell. Infect. Microbiol. 12, 892232 (2022).
Article CAS PubMed PubMed Central Google Scholar
Brunius, C., Shi, L. & Landberg, R. Metabolomics for improved understanding and prediction of cardiometabolic diseasesrecent findings from human studies. Curr. Nutr. Rep. 4, 348364 (2015).
Article CAS Google Scholar
Johnson, M. Diet and nutrition: implications to cardiometabolic health. J. Cardiol. Cardiovasc. Sci. 3, 49 (2019).
Doran, S. et al. Multi-omics approaches for revealing the complexity of cardiovascular disease. Brief. Bioinformatics 22, bbab061 (2021).
Article PubMed Google Scholar
Joshi, A., Rienks, M., Theofilatos, K. & Mayr, M. Systems biology in cardiovascular disease: a multiomics approach. Nat. Rev. Cardiol. 18, 313330 (2020).
Article PubMed Google Scholar
Abu-Ali, G. S. et al. Metatranscriptome of human faecal microbial communities in a cohort of adult men. Nat. Microbiol. 3, 356366 (2018).
Article CAS PubMed PubMed Central Google Scholar
Schirmer, M. et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat. Microbiol. 3, 337346 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zierer, J. et al. The fecal metabolome as a functional readout of the gut microbiome. Nat. Genet. 50, 790795 (2018).
Article CAS PubMed PubMed Central Google Scholar
Quince, C., Walker, A. W., Simpson, J. T., Loman, N. J. & Segata, N. Shotgun metagenomics, from sampling to analysis. Nat. Biotechnol. 35, 833844 (2017).
Article CAS PubMed Google Scholar
Martinez, K. B., Leone, V. & Chang, E. B. Microbial metabolites in health and disease: navigating the unknown in search of function. J. Biol. Chem. 292, 85538559 (2017).
Article CAS PubMed PubMed Central Google Scholar
Douglas, G. M. et al. PICRUSt2 for prediction of metagenome functions. Nat. Biotechnol. 38, 685688 (2020).
Article CAS PubMed PubMed Central Google Scholar
Shakya, M., Lo, C.-C. & Chain, P. S. G. Advances and challenges in metatranscriptomic analysis. Front. Genet. 10, 904 (2019).
Article CAS PubMed PubMed Central Google Scholar
Valles-Colomer, M. et al. Meta-omics in inflammatory bowel disease research: applications, challenges, and guidelines. J. Chrons Colitis 10, 735746 (2016).
Article Google Scholar
Kleiner, M. Metaproteomics: much more than measuring gene expression in microbial communities. mSystems 4, e00115-19 (2019).
Article PubMed PubMed Central Google Scholar
Roberts, L. D., Souza, A. L., Gerszten, R. E. & Clish, C. B. Targeted metabolomics. Curr. Protoc. Mol. Biol. 98, 30.2.130.2.24 (2012).
Article Google Scholar
Menni, C., Zierer, J., Valdes, A. M. & Spector, T. D. Mixing omics: combining genetics and metabolomics to study rheumatic diseases. Nat. Rev. Rheumatol. 13, 174181 (2017).
Article CAS PubMed Google Scholar
Kule, J. et al. Combined untargeted and targeted metabolomics approaches reveal urinary changes of amino acids and energy metabolism in canine babesiosis with different levels of kidney function. Front. Microbiol. 12, 715701 (2021).
Article PubMed PubMed Central Google Scholar
Hollywood, K., Brison, D. R. & Goodacre, R. Metabolomics: current technologies and future trends. Proteomics 6, 47164723 (2006).
Article CAS PubMed Google Scholar
Linnarsson, S. & Teichmann, S. A. Single-cell genomics: coming of age. Genome Biol. 17, 97 (2016).
Article PubMed PubMed Central Google Scholar
Pasolli, E. et al. Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle. Cell 176, 649662.e20 (2019).
Article CAS PubMed PubMed Central Google Scholar
Almeida, A. et al. A unified catalog of 204,938 reference genomes from the human gut microbiome. Nat. Biotechnol. 39, 105114 (2021).
Article CAS PubMed Google Scholar
Llorns-Rico, V., Simcock, J. A., Huys, G. R. B. & Raes, J. Single-cell approaches in human microbiome research. Cell 185, 27252738 (2022).
Article PubMed Google Scholar
Lagier, J.-C. et al. Culturing the human microbiota and culturomics. Nat. Rev. Microbiol. 16, 540550 (2018).
Article CAS PubMed Google Scholar
Van de Wiele, T., Van den Abbeele, P., Ossieur, W., Possemiers, S. & Marzorati, M. in The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models 305317 (Springer International Publishing, 2015).
Minot, S. et al. The human gut virome: inter-individual variation and dynamic response to diet. Genome Res. 21, 16161625 (2011).
Article CAS PubMed PubMed Central Google Scholar
Garmaeva, S. et al. Stability of the human gut virome and effect of gluten-free diet. Cell Rep. 35, 109132 (2021).
Article CAS PubMed Google Scholar
Scarpellini, E. et al. The human gut microbiota and virome: potential therapeutic implications. Dig. Liver Dis. 47, 10071012 (2015).
Article PubMed PubMed Central Google Scholar
Warmbrunn, M. V. et al. Gut microbiota: a promising target against cardiometabolic diseases. Expert Rev. Endocrinol. Metab. 15, 1327 (2020).
Article CAS PubMed Google Scholar
Herold, M. et al. Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance. Nat. Commun. 11, 5281 (2020).
Article CAS PubMed PubMed Central Google Scholar
Falony, G. et al. Population-level analysis of gut microbiome variation. Science 352, 560564 (2016).
Article CAS PubMed Google Scholar
Zhernakova, A. et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science 352, 565569 (2016).
Article CAS PubMed PubMed Central Google Scholar
Fromentin, S. et al. Microbiome and metabolome features of the cardiometabolic disease spectrum. Nat. Med. 28, 303314 (2022).
Article CAS PubMed PubMed Central Google Scholar
Asnicar, F. et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat. Med. 27, 321332 (2021).
Wilmes, P., Heintz-Buschart, A. & Bond, P. L. A decade of metaproteomics: where we stand and what the future holds. Proteomics 15, 34093417 (2015).
Article CAS PubMed PubMed Central Google Scholar
Lloyd-Price, J. et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 569, 655662 (2019).
Article CAS PubMed PubMed Central Google Scholar
Zhou, W. et al. Longitudinal multi-omics of hostmicrobe dynamics in prediabetes. Nature 569, 663671 (2019).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Y. et al. Discovery of bioactive microbial gene products in inflammatory bowel disease. Nature 606, 754760 (2022).
Article CAS PubMed PubMed Central Google Scholar
Oliveira, P. H. Bacterial epigenomics: coming of age. mSystems 6, e0074721 (2021).
Article PubMed Google Scholar
Hiraoka, S. et al. Metaepigenomic analysis reveals the unexplored diversity of DNA methylation in an environmental prokaryotic community. Nat. Commun. 10, 159 (2019).
Article PubMed PubMed Central Google Scholar
Singh, R. K. et al. Influence of diet on the gut microbiome and implications for human health. J. Transl. Med. 15, 73 (2017).
Article PubMed PubMed Central Google Scholar
Rothschild, D. et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 555, 210215 (2018).
The rest is here:
Cardiometabolic health, diet and the gut microbiome: a meta-omics ... - Nature.com
Humans are altering the diet of Tasmanian devils, which may … – Science Daily
The Tasmanian devil roams the island state of Australia as the apex predator of the land, feeding on whatever it pleases as the top dog -- or the top devil. But some of these marsupial scavengers could be starting to miss out on a few items from the menu.
According to a study led by UNSW Sydney, living in human-modified landscapes could be narrowing the diet of the Tasmanian devil. The research, published recently in Scientific Reports, suggests devils have access to vastly different cuisines depending on the type of environment they live in.
"We found Tasmanian devil populations had different levels of variation in their diet depending on their habitat," says Anna Lewis, a PhD candidate at UNSW Science and lead author of the study. "The more that habitat was impacted by humans, the more restrictive the diet became."
A previous study by the team found most devils are individual specialists, feeding on the same food items consistently over time. But human impacts could be influencing whether they have access to their favourite foods.
"How humans change the environment impacts the animals within them," says Professor Tracey Rogers, an ecologist at UNSW Science and senior author of the study. "Even small changes can have significant consequences for devils, so we need to be mindful of the consequences of our actions."
The devil is in the details
For the study, the researchers investigated the diets of devil populations across habitats of differing levels of disturbance, from cleared pasture to undisturbed rainforest. They did this by analysing chemical stamps called stable isotopes in whisker samples taken from Tasmanian devils in different environments.
"It's similar to how tree rings capture chemical signals about atmospheric elements over time. We're doing the same thing with the devils, matching up the biochemical signatures in the whiskers to the prey so we can learn more about what the devils are eating," Prof. Rogers says.
They found devils in human-impacted landscapes, such as cleared land and regenerated native forests, fed on the same food items, primarily medium-sized mammals. Meanwhile, in environments like rainforest areas, devils ate a broader range of prey and incorporated smaller animals, such as birds, into their diets.
"We found devils in heavily altered areas like cleared land fed on a smaller range of prey compared to populations living in ancient undisturbed regions, who had much more variety in their diet," Ms Lewis says. "They may be turning to human-derived sources of food, such as highway roadkill, which are more readily available."
Interestingly, devils living in regenerated native eucalypt forests also ate a smaller variety of food items. Comparatively, their diets were closer to the devils in cleared agricultural land than those from undisturbed forest regions.
"These regenerated forests not logged for many decades may look like natural landscapes to us, but the devils that live there have similar simple diets to the devils that live on cleared agricultural pastures," Prof. Rogers says.
"The regenerated land doesn't have the complex features such as tree hollows in large old trees to support diverse bird life and small mammals that the devil eats in the rainforest."
Restrictive diets could increase threat
Devils that all maintain the same diet run the risk of interacting more frequently around carcasses, which is of particular concern for spreading the highly contagious and fatal cancer, Devil Facial Tumour Disease (DFTD). The disease has already reduced local devil populations by 82 per cent and spread to most of Tasmania.
"The highest rate of cancer transmission other than during the mating season occurs when they're feeding around these large carcasses," Ms Lewis says. "So, there could be an increased chance for the disease to spread amongst devils, and the devils themselves are also at risk of being hit while feeding."
The researchers say the findings highlight the urgent need to protect what remains of untouched landscapes for both the devils and the species they eat.
"It's apparent there is much more diversity of species available in these old-growth forests, and the devils are shining a light on how vital these pristine areas are, and the urgent need to preserve what remains from the constant threat of clearing and mining," Prof. Rogers says.
In the next stage of the research, they hope to investigate the eating habits of devils in native grasslands to better inform conservation efforts across more habitats.
"By better understanding what is impacting devil diets, we can work to protect this iconic Australian animal and ensure their continued survival in the face of ongoing environmental change," Ms Lewis says.
More here:
Humans are altering the diet of Tasmanian devils, which may ... - Science Daily
New research establishes how and why Western diets high in sugar … – Science Daily
New research from the University of Missouri School of Medicine has established a link between western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease.
The research, based in the Roy Blunt NextGen Precision Health Building at MU, has identified the western diet-induced microbial and metabolic contributors to liver disease, advancing our understanding of the gut-liver axis, and in turn the development of dietary and microbial interventions for this global health threat.
"We're just beginning to understand how food and gut microbiota interact to produce metabolites that contribute to the development of liver disease," said co-principal investigator, Guangfu Li, PhD, DVM, associate professor in the department of surgery and Department of Molecular Microbiology and Immunology. "However, the specific bacteria and metabolites, as well as the underlying mechanisms were not well understood until now. This research is unlocking the how and why."
The gut and liver have a close anatomical and functional connection via the portal vein. Unhealthy diets change the gut microbiota, resulting in the production of pathogenic factors that impact the liver. By feeding mice foods high in fat and sugar, the research team discovered that the mice developed a gut bacteria called Blautia producta and a lipid that caused liver inflammation and fibrosis. That, in turn, caused the mice to develop non-alcoholic steatohepatitis or fatty liver disease, with similar features to the human disease.
"Fatty liver disease is a global health epidemic," said Kevin Staveley-O'Carroll, MD, PhD, professor in the department of surgery, one of the lead researchers. "Not only is it becoming the leading cause of liver cancer and cirrhosis, but many patients I see with other cancers have fatty liver disease and don't even know it. Often, this makes it impossible for them to undergo potentially curative surgery for their other cancers."
As part of this study, the researchers tested treating the mice with an antibiotic cocktail administered via drinking water. They found that the antibiotic treatment reduced liver inflammation and lipid accumulation, resulting in a reduction in fatty liver disease. These results suggest that antibiotic-induced changes in the gut microbiota can suppress inflammatory responses and liver fibrosis.
Li, Staveley-O'Carroll and fellow co-principal investigator R. Scott Rector, PhD, Director of NextGen Precision Health Building and Interim Senior Associate Dean for Research -- are part of NextGen Precision Health, an initiative to expand collaboration in personalized health care and the translation of interdisciplinary research for the benefit of society. The team recently received a $1.2 million grant from the National Institutes of Health to fund this ongoing research into the link between gut bacteria and liver disease.
Read the original here:
New research establishes how and why Western diets high in sugar ... - Science Daily
Endometriosis Diet: What to Eat and Avoid – Verywell Health
Diet alone cannot cure or treat endometriosis. However, dietary changes may assist in maintaining, treating, and recovering from the condition. Food can affect hormone levels, inflammation, and weight, all of which are factors that impact the progression and severity of endometriosis.
Foods rich in antioxidants and omega-3 fatty acids, such as fruits, vegetables, nuts, seeds, and fatty fish, can reduce inflammation, therefore, helping to reduce pain from endometriosis.
This article discusses dietary changes for endometriosis, foods that help to fight inflammation, when to seek medical help, and more.
Alexander Spatari / Getty Images
A nutritious eating plan is an important component of overall health and longevity. If you have endometriosis and are having trouble controlling your symptoms, adopting some dietary changes to reduce inflammation may help manage your pain.
In addition, changing your diet may increase your chances of getting pregnant if you're trying to conceive. However, results are very individual and will differ based on the stage and severity of your endometriosis.
Chronic pelvic and abdominal pain is a common symptom of endometriosis. Ongoing pain may mean you are experiencing a great deal of inflammation. Though changing your diet won't completely alleviate your symptoms, there is no harm in trying.
Some people with endometriosis have flare-ups before or during menstruation. Others experience symptoms constantly, randomly, or with changes, often increasing in frequency and worsening with time.
Changing your eating habits during these times may help, especially if you experience digestive problems like constipation. Increasing fiber and fluid intake can help treat constipation.
One study evaluated the effects of a Mediterranean-style diet in women with a previous laparoscopic diagnosis of endometriosis and postoperative endometriosis-associated pain.
Participants followed an eating plan that included fresh vegetables, fruit, white meat, fatty fish, soy products, magnesium-rich foods, and cold-pressed oils. They were asked to avoid sugary drinks, red meat, sweets, and animal fats. Researchers found significant improvements in the condition, including:
People with endometriosis are at increased risk of having problems with fertility. If you are trying to conceive, what you eat can positively impact your fertility.
Research shows eating a diet that includes low-mercury seafood about twice per week, whole grains, fruits, and vegetables may improve fertility in both men and women.
In addition, certain nutrients are required for a healthy pregnancy, including:
Endometriosis can cause endo lesions within the pelvis and other body parts outside the pelvis. Lesions are frequently found on the ovaries, ligaments, peritoneal surface, bowel, and bladder.
Although no specific endometriosis diet exists, certain foods high in antioxidants are encouraged to reduce inflammation. The Mediterranean diet has proved capable of decreasing markers of inflammation. This eating style consists of fruits, vegetables, legumes, whole grains, fatty fish, olive oil, nuts, and seeds while limiting trans fat, saturated fat, and sugary foods.
Foods that contain magnesium and zinc can help you reduce inflammation. Magnesium-rich foods include whole grains, legumes, nuts, seeds, dairy products, and green leafy vegetables. Meanwhile, oysters, beef, pumpkin seeds, eggs, dairy products, fortified breakfast cereals, oats, whole grains, and legumes contain zinc.
Endometriosis growth is stimulated by estrogen. Eating foods that help remove estrogen and prevent levels from getting too high may prove beneficial. Fiber-rich foods can help pull estrogen out of the body through bowel movements. Foods high in fiber include fruits, vegetables, whole grains, nuts, seeds, and legumes.
Foods with omega-3 fats help calm inflammation, which may reduce the severity of symptoms and potentially reduce the progression of endometriosis. Omega-3 fatty acids are found in fish, such as salmon, sardines, tuna and walnuts, flaxseeds, chia seeds, plant-based oils, and fortified foods.
One study linked a higher intake of dairy products, such as milk, yogurt, and cheese, to a lower risk of endometriosis. The association appeared greater when intake was more than three servings per day. Researchers believe this association may occur because these foods are rich in calcium, vitamin D, and magnesium.
It is important to speak to a healthcare provider before taking any supplements. You want to ensure that the supplements you are choosing do not interfere with any current medications you are taking, that they are from a reliable source, and that their dosages are not too high.
The type of supplements you choose will depend on what result you are looking to achieve. If you are trying to conceive, you should take a prenatal vitamin that contains folic acid and choline. Other supplements that may be recommended include zinc, magnesium, probiotics, vitamin C, vitamin D, quercetin, curcumin, vitamin E, and omega-3 fatty acids.
Research suggests that foods high in trans fat and sugar can increase inflammation. Higher intakes of trans fat have also been associated with a greater chance of developing endometriosis.
Foods high in trans fat include:
It doesn't mean you can never eat these foods again, but limiting your intake may help. It also opens up more room for other foods, such as fresh fruits and vegetables, which can be beneficial.
Phytoestrogens are naturally occurring estrogen-like compounds found in plants. Dietary sources of phytoestrogens are found in fruits, vegetables, spinach, sprouts, beans, cabbage, soybeans, grains, and oilseeds (such as flaxseed).There are different classes of phytoestrogens, including isoflavones, coumestans, lignans, and flavonoids.
The data on phytoestrogens and endometriosis is complex and inconsistent. Some research suggests that phytoestrogens can have an anti-estrogen effect and help reduce inflammation, while other research has found the opposite.
The complexity resides in how much estrogen a person has and the types and amounts of phytoestrogens consumed. Many studies are short and include animals, which makes it hard to formulate one answer. Researchers acknowledge the need for studies longer in duration.
Natural remedies, like complementary and alternative medicine (CAM), are interventions not part of standardized care. In treating endometriosis, these natural approaches may include:
Ask a healthcare provider if these approaches can help you.
Having meal ideas to work from can help you change your eating patterns. It can save you time, money, and stress. You don't need to eat precisely this way. Use these suggestions as a guide for planning and preparing meals rich in anti-inflammatory foods, fiber, and micronutrients:
Breakfast:
Lunch:
Dinner:
Snacks:
Working with a registered dietitian (RD) is important when creating an eating plan and making dietary changes while managing a condition. They can customize individualized eating by taking into consideration all of your personal needs, medical history, culture, and food preferences.
RDs can also examine your eating history to ensure an adequate intake of important vitamins and nutrients (protein, fat, and carbohydrates). They can assess if supplements are necessary and guide you on how to take them safely.
Changing your dietary habits may not cure endometriosis, but research shows that eating a diet rich in certain nutrients can help reduce inflammation. You don't have to overhaul your entire diet at once. Simply start by making small changes and see how you feel. If you need assistance, consider working with a dietitian who can customize a plan that suits your needs and goals.
View post:
Endometriosis Diet: What to Eat and Avoid - Verywell Health
Im a gym girl my diet and exercise secrets transformed my body like no other, now Im sharing them… – The US Sun
A FITNESS fan has revealed her go-to regimen for achieving the figure of her dreams.
She said her diet and exercise plan transformed her entire look.
5
Daria (@yourfavegymbestie) shared a video of herself prior to the glow-up.
"Watch me transform my body like no other," she said.
She took off a waist trainer belt, pouring sweat from a clearly strenuous work out.
Next, she revealed chiseled abs and increased muscle definition.
The gym girl appeared to be more confident with her new physique as she posed for the camera.
"Fitness changes lives," she added in the caption.
She suggested following her fitness and nutrition coaching, linking a YouTube video of her dedicated regimen as well as her personalized training program.
In the video, Daria revealed that she hits the weights with a warm-up, followed by "slow and controlled" weight-lifting, and finishes off with "30 minutes of cardio on the StairMaster."
Her post-workout meal consisted of "chicken, asparagus, and sweet potato."
The video came as part of a popular trend of fitness influencers sharing how working out changed their lives.
Many gym-goers are sharing the power of exercise, even candidly documenting their glow-up.
Daria's video stunned viewers, who shared their thoughts on her transformation.
"Its not the sweat belt," one wrote. "You simply need to eat plenty of real whole foods, but in a calorie deficit and lift three to five days a week."
"This one," Daria replied. "The sweat belt simply gets rid of water retention put on throughout the day.
"Babes nutrition is [key] add in lifting and cardio and you're gold."
"Hard work and dedication ladies," another added. "So proud of you girl."
"Wow this is amazing," a third commented. "Youre inspiring."
5
5
5
5
The Real-Life Diet of Himanshu Suri, Who Accidentally Got Jacked – GQ
I'm the guy that always ate pizza and cheeseburgers, Himanshu Suri tellsGQ. I made a song about Pizza Huts and Taco Bells!
True: In 2010, the rapper, formerly of the group Das Racist, best known by his stage name Heems, created a generational earworm with Combination Pizza Hut and Taco Bell. These days, the 37-year-olds life looks pretty different. Suri is working on a new album, preparing to host a podcast about cricket, and starting his own DTC business with goods from India. He also got sober, started hitting the gym, and gave up fast food in favor of green smoothies and protein.
View more
On Twitter, Suri has been documenting his wellness journey withbefore and after pics and wry jokes. He spoke toGQabout his weight training routine, doing service work after the gym, and the life-changing magic of getting jacked as a bit.
For Real-Life Diet, GQ talks to athletes, celebrities, and other high performers about their diet, exercise routines, and pursuit of wellness. Keep in mind that what works for them might not necessarily be healthy for you.
GQ:You said that youre getting jacked as a bit. Tell me more about that.
Himanshu Suri:I don't know why and how that came to be, but it felt a little strange to become a gym and fitness person. I felt more comfortable with the notion of spending every day in the gym as just a little jokesee what happens, ha ha ha. And it's the bit that keeps on giving back.
Were you a gym person at all before this or is this truly your first time getting into a routine?
I have dabbled in the gym. I definitely was more into yoga than actually lifting or doing cardio, but in the last six months or so, I started getting more into using the weight machines.
Tell me about the first day you went back and how you built up to whatever your routine is now.
I wanted to incorporate some swimming as cardio. The gym I go to was like, "Oh yeah, the pool will be ready, the pool will be ready." And the pool, a year later, is not ready. My routine is, I do about 75 to 100 sit-ups every day on a decline bench. I do three to five sets of vertical chest presses. I do three to five sets of a lat pulldown machine, and then I do three to five chest supported landmines.
Did recovery lead to you working out, or vice versa?
Working out has always been a part of recovery. It wasn't so much that one proceeded or came after the other. But I always view yoga or exercise along with therapy, medication, and fellowship as parts of recovery.
Was there anyone who you turned to for advice on what to do in the gym, or did you just try whatever felt good?
It was definitely self-taught. The free weights are where all the guys are in the gym and I still feel intimidated by the bros. I do the machines that mostly the old people do. So it was following my intuition of being intimidated by gym culture but still wanting to be active.
What are the main benefits you've noticed from getting in the gymfrom the physical results all the way to how its impacted your creative process?
Its a three part processmental, physical, and spiritualand they all kind of bleed into one another. I definitely feel less depression and anxiety from working out. And living a healthier life in terms of exercise and food, and especially sobriety, has helped me build a stronger spiritual practice. Just having the focus or energy to meditate, to pray daily. It really helps that the gurdwara, the Sikh temple, I go to is close to the gym. I go from the gym to the gurdwara on my drive home every day. They're linked quite literally in my mind.
I definitely sleep better. I have more energy, more focus, but it all kind of comes back to having a connection with the spirit world. And to tie that to music, I do feel like I'm channeling something greater than myself, as narcissistic as that may sound. What I found more recently is I can't write or record as much in one session without weed or alcohol. But I'm able to write about one thing, one concept, one song, one idea. And I think that comes from, again, just being in better mental, physical, and spiritual health.
Did your diet change at all and what does a typical day of eating look like for you now?
My diet actually hasn't changed much because I suffered from a lot of depression. I didn't look forward to or get excited about eating. So I found myself making a lot more smoothies just because it was mechanically convenient to eat in that way. I've been big on smoothies the last four or five years. What I put in them are mixed greens, cucumbers, celery, blueberries, occasionally one more fruit, like citrus or mango, and then nuts, ginger, turmeric, ashwagandha powder, and a green nutrients powder.
I love eggs in the morning if I'm eating before noon, but I try to incorporate as much of at least the beginning part of intermittent fasting, so I don't eat until later on in the day. And then I eat a lot of tandoori chicken, chicken tikka, or malai chicken. When I can afford it, I like sashimi.
I used to eat a lot of pizza and cheeseburgers and used to definitely order way too much from delivery services. But I've really cut that out in the last year or so for a multitude of reasons. And I don't get bored with eating the same things every day. I really like chicken tikka.
Do you have any food rules at all or do you try to keep it intuitive?
Yeah, I don't really. I'm not a stickler on diet. If I still want to eat pizza or something, I definitely do. I don't have designated cheat days. I just try to get in the gym. I've been eating more roti, even though, when I'm trying hard, I don't eat any kind of bread. But lately I've been eating roti. Something I really need to work on is not eating late at night.
Oh man. I feel you.
I definitely will miss breakfast all the time, but have lunch and two dinners. Unfortunately my dog is following my eating habits and expects a proper amount of food at 11:00 p.m., so that's not really good.
Whats the most surprising thing to come out of your wellness journey?
100% this interview. I think this is hilarious. And I think people that grew up with me would think this is hilarious. Because I'm the guy that always ate pizza and cheeseburgers. I made a song about Pizza Huts and Taco Bells! So I just think it's kind of fascinating that I've put in a lot of time and effort into this journey and hopefully this piece can help other people who don't think that it's possible or it's a lot of work to change your life like this. But the rewards are well worth it.
Something else funny about this whole thing is that I wasn't trying to get my arms to be bigger. I definitely wanted to stay lean. But I did not register that my arms would get bigger. And one day I was looking in the mirror and it felt like a circus mirror. I was like, "This is fucking weird. I didn't sign on for all this shit. So I think I probably should have tried more cardio and less weightlifting. But I'm also happy with the way I look. That wasn't what I went into it for though. It's been kind of a pleasant surprise. But it came from the place of just wanting to incorporate movement and routine into my life.
And then you accidentally got jacked.
Yeah. And then I accidentally got jacked and now I brush it off as a joke because I used to judge people who were in the gym every day. Its like, if I call it a joke then it'll be less corny to me.
This interview has been edited and condensed.
Continued here:
The Real-Life Diet of Himanshu Suri, Who Accidentally Got Jacked - GQ