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Mar 2

NATO Trains For Submarine Warfare As More Attack Boats Prowl the Med – USNI News

Italian submarine ITS Salvatore Todaro (S 526) and Canadian frigate HMCS Fredericton (FFH 337) sail in the Ionian Sea during an anti-submarine warfare demonstration for media on Feb. 24, 2020, during the kickoff of NATOs Dynamic Manta exercise. USNI News photo.

ABOARD ITS CARABINIERE, IN THE IONIAN SEA All across the Mediterranean Sea, more non-NATO countries are fielding submarines while NATO allies are increasing the size of their own undersea fleets. Those submarines are also becoming harder to find.

All told, the ability for NATO to find, track and identify submarines is not just a matter of defense against Russia, but a matter of basic traffic safety on and under the Mediterranean.

Set against the backdrop of the increasingly crowded Med, NATO is hosting the Dynamic Manta 2020 anti-submarine warfare exercise, bringing together nine nations to combine ASW capabilities from ships, maritime patrol aircraft, helicopters and submarines, and improve their ability to work together to keep these southern European waters safe.

Dynamic Manta was designed to train, to prepare, to test our ability in a very particular domain, that is the anti-submarine warfare, Italian Navy Rear Admiral Paolo Fantoni, who commands Standing NATO Maritime Group 2, said ahead of the kickoff of the exercise.All this to facilitate the integration of forces. That is the goal and the strength of NATO: the capability for the alliance to operate with different forces from different nations using the same standards and procedures, and to be able to react properly to any type of emergency.

SNMG-2 commands the surface forces in the exercises and is one of four very high readiness surface forces that NATO maintains under its Maritime Command (MARCOM).

Canadian frigate HMCS Fredericton (FFH 337) and a helicopter participate in an anti-submarine warfare demonstration for media on Feb. 24, 2020, at the kickoff of the NATO Dynamic Manta 2020 exercise. USNI News photo.

Fantoni told USNI News during an interview aboard SNMG-2 flagship ITS Carabiniere (F 593) that ASW is tough enough for one nation to do, but combining ships and aircraft from multiple countries is a challenge. Each bring different kinds of sensors onboard ships and aircraft of different ages and sophistication. For example, under his command is Italian frigate Carabiniere, an ASW-variant FREMM frigate that delivered to the fleet in 2015. Also in the task group is Hellenic Navy frigate HS Aegean (F 460), which was commissioned into the Royal Netherlands Navy in 1980, sold to Greece in 1993 and modernized in 2010. Fantoni said all the ships are trained to certain NATO standards before they are assigned to a NATO group like SNMG-2, but his job is to figure out how to make the most of the differing capabilities each ship brings.

We need to operate as a force not Carabiniere acting on her own and (Canadian frigate) Fredericton and the others on their own the ships are a part of the scenario for the interactions: they have to achieve some goals, to detect the submarines, to take some actions against the submarines, and vice versa to defend themselves, to defend a nearby unit from a submarine attack, he said, calling it a force-multiplier when they can share information and hunt a sub collectively rather than operating in proximity but independently.

Everyone involved in the exercise can perform some ASW, but some assets bring especially advanced capabilities: Carabiniere has a variable-depth sonar, some helos have a dipping sonar to supplement their airborne sensors, the fixed-wing planes have great endurance and range.

Its like an orchestra. I feel like, really, a director of an orchestra to use different instruments as much as they can contribute to my mission, Fantoni said.

In the complex undersea environment in the Mediterranean, squeezing out the most capability from SNMG-2 and the ships and aircraft it partners with during exercises like Dynamic Manta is key.

This August, Russia did Exercise Ocean Shield, which was the largest post end of the Cold War exercise conducted by Russia. And one of the components of [NATOs Supreme Allied Commander Europe]s guidance is that we conduct deterrence and defense of the Euro-Atlantic Area. The point of Dynamic Manta is to show a credible defense, that we have the ability to act interoperably within the ASW realm, Rear Adm. Andy Burcher, commander of NATO submarines at MARCOM, said during a press conference aboard Carabiniere on Feb. 24 the first day of the exercise.In addition to that, I would say that all of the large number of nations that surround the Mediterranean are increasing the number of submarines that are operating in the Mediterranean: Algeria, Egypt, Russia and Israel are now all operating submarines in the Mediterranean. And a large number of our NATO alliance countries are increasing their submarine footprint in the area: Spain, Italy, Turkey, I believe Greece, are all conducting expansion programs within the submarine realm. So from a submarine perspective, the number of submarines that are operating in the Mediterranean is increasing, so its important that we understand how the Mediterranean operates, and in particular, all of these submarines that are coming in have advanced capabilities in comparison to the past. So we have to stay both proficient and capable in the ASW realm. So those are the factors that I see in the Mediterranean that make this exercise important.

On Russia specifically, Fantoni said that, they are military vessels, they dont belong to the alliance, they are present so we could consider them as a threat, but I dont see a threat, an immediate threat to the forces. We respect their potential capability but also confident that we are as well prepared for any type of emergency.

A helicopter from Italian frigate ITS Carabiniere (F 593) lowers its dipping sonar into the Ionian Sea on Feb. 24, 2020, during an anti-warfare demonstration for media at the kickoff of NATO exercise Dynamic Manta. USNI News photo.

If the purpose of NATOs four standing maritime groups is to ensure theres always a task group integrated and ready to respond to an emergency, the purpose of exercises like Dynamic Manta and its sister exercise in the North Atlantic, Dynamic Mongoose, is to allow those task groups to prove their proficiency in specialized warfare areas.

Burcher said during the press conference that, if a war were to break out, NATO countries could bring a great number of submarines to the fight: 12 NATO countries have a combined 69 submarines, and though the U.S. Navy typically doesnt lend its submarines to NATO for tasking, it could bring about 30 Atlantic-based subs to the fight if the need arose. Those 100 subs, plus the frigates and destroyers and helicopters and maritime patrol aircraft that would supplement them in a hypothetical fight against the Russian submarine fleet, are all capable assets but integration only comes through practice. By rotating which nations are involved in the standing groups and which participate in exercises like Dynamic Manta, all nations are exposed to some amount of integrated theater ASW operations through NATO and are able to develop some sort of institutional knowledge.

In Dynamic Manta 2020, a series of CASEXs increase in complexity, from familiarization efforts up through a graduating event of coordinated theater ASW with air, surface and subsurface assets contributing to finding an enemy submarine, Burcher explained. Early on, a ship might be told that the target is in its operating box and be given its course and speed to see if it can positively find and identify the submarine with its systems; by the end, the ship might be told a target is within its operating box but it wont have any clues as to its location or course.

Four submarines are participating, with subs serving as targets as well as ASW assets. Nine countries total are involved, as well as NATOs Center for Maritime Research and Experimentation, which is bringing unmanned undersea vehicles and gliders to contribute to sub-hunting operations while also testing out the new gear and new tactics, which Burcher said brings in an extra added tool to the undersea fight.

A helicopter tracks Italian submarine ITS Salvatore Todaro (S 526) in the Ionian Sea on Feb. 24, 2020, during an anti-submarine warfare demonstration for media at the kickoff of the NATO Dynamic Manta 2020 exercise. USNI News photo.

Fantoni said MARCOM is constantly identifying gaps, noting lessons learned, testing out new concepts to fix those gaps, and then ultimately updating doctrine so NATO forces will train to the best and most relevant capabilities. Much of this is driven by ever-changing capabilities both in NATO assets as well as potential target submarines.

Technology is evolving very very quick, and of course we adapt our doctrine to the new capabilities. One basic example: if in the past your sensors were able to detect a submarine at 10 kilometers, and now your sensor allows you to detect beyond that limit, you need to adjust to how you intend to use the tactics that goes behind it, Fantoni told USNI News.But also the submarines are getting new technology, so we change on a yearly basis from exercise to exercise.

Dynamic Manta takes place in the Ionian Sea, in the Central Mediterranean in waters with relatively less commercial shipping traffic. Dynamic Mongoose takes place in Northern Europe, typically rotating between the Norwegian Sea and the North Atlantic Ocean to allow northern NATO navies to practice in shallower waters and in the deep ocean.

Fantoni called Dynamic Manta and Mongoose two of the most interesting and viable activities and represent today the highest level of integration of forces in anti-submarine warfare. Very beneficial to surface vessels, for maritime patrol aircraft, and indeed for the submarines.

Submarines are constantly improving their stealth, their quietness. They are improving in their tactics and the sensors that they have, and so these types of exercises allow us to really put theory to practice and make sure that we understand what were doing in a highly complex environment, Burcher said.Because anti-submarine warfare requires both air, surface and submarine assets to detect the other submarines, its important that we learn how to and we practice in a combined environment.

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NATO Trains For Submarine Warfare As More Attack Boats Prowl the Med - USNI News


Mar 2

Who We Are As Eaters? – Thrive Global

Most of us have been taught to believe that good nutrition is simply a function of eating the right food and taking the right supplements. Of course, this is true, but theres more to the equation. What we eat is only half the story of good nutrition.

The other half of the story is who we are as eaters. That is, what we think, feel, believe, as well as our levels of stress, relaxation, pleasure, awareness, and the inner stories that we live out all have a real, powerful, and scientific effect on nutritional metabolism.

Recent advances in the mind-body sciences have been proving what ancient wisdom traditions have been saying for eons that the mind and body exist on an exquisite continuum, and profoundly impact one another.

So the good news is simply this: you can powerfully change your health and your nutritional status without changing anything you eat, but by changing you the eater.

Consider some of these key secrets that I think everyone should know:

Stress can put weight on relaxation can take it offIts fascinating how stress, fear, anxiety, anger, judgment, and even negative self-talk can literally create a physiologic stress response in the body. This means that we generate more cortisol and insulin, two hormones that have the unwanted effect of signaling the body to store weight, store fat, and stop building muscle. Strange as it may sound, we quite literally change our calorie burning capacity when were stressed. Whats more incredible though, is that, as we learn to smile more, ease into life, and breathe more deeply, the body enters a physiologic relaxation response. In this state, we actually create our optimal day-in, day-out calorie-burning metabolism. So, you could be following the best weight loss diet in the world, but if youre an anxious mess, the power of your mind is limiting the weight loss of your body. Far too many people adopt stressful weight loss strategies; impossible-to-follow diets, overly intense exercise programs, tasteless food, and extremely low-calorie meal plans, all of which can create the kind of stress chemistry that ensures our weight will stay put. Its time to relax into weight loss.

Happiness is the best digestive aidCan you recall what happens when you eat during anxiety or stress? Many people report such symptoms as heartburn, cramping, gas, and digestive upset. During stress, the body automatically shifts into the classic fight-or-flight response. This feature of the nervous system evolved over millions of years as a brilliant safety mechanism to support us during life-threatening events. At the moment the stress response is activated, something very interesting happens the digestive system shuts down. It makes perfect sense that when youre fending off an angry gorilla, you dont need to waste energy digesting your breakfast. All the bodys metabolic energy is directed towards survival. So, you could be eating the healthiest food in the universe, but if you arent eating under the optimum state of digestion and assimilation, which happens to be relaxation, you literally and metabolically are not receiving the full nutritional value of your meal.

Overeating its simpler than you thinkMost people think they overeat because they have a willpower problem. If only I could control my appetite, then I would stop being such a willpower weakling and start losing weight. Well, heres the good news you dont have a willpower problem. The problem for the majority of overeaters is that they dont actually eat when they eat. What Im suggesting is that we arent always fully present to the meal, aware of its taste, eating it slowly, or simply feeling nourished by the food. When this happens, the brain, which requires taste and satisfaction, misses out on a key phase of the nutritional experience. The brain literally thinks it didnt eat or didnt eat enough. And it simply screams back at us Hungry! So, you can dramatically decrease your overeating by increasing your awareness and presence at every meal.

Slower eating means a faster metabolismOne of my favourite nutritional questions to ask a client or student is are you a fast eater, moderate eater, or slow eater? If the answer is fast, then its time for an overhaul. Thats because the act of eating fast is considered a stressor by the body. Humans are simply not biologically wired for high-speed eating. So when we do eat fast, the body once again enters the physiologic stress response, which results in decreased digestion, decreased nutrient assimilation, increased nutrient excretion, lowered calorie-burning rate, and a bigger appetite. The bottom line is that you can literally empower your nutritional metabolism simply by slowing down. Whats fascinating is that for many fast eaters, slowing down is quite a challenge. But try this dont just eat slow eat sensuously, feel nourished by your food, and take in all the sensations of your meal.

Make sure you have enough Vitamin P Pleasure!Far too many people are taught to believe that pleasure is something frivolous. Well, its actually required by our biology. All organisms on planet earth, be they lion, lizard, amoeba, or human, are programmed at the most primitive level of the nervous system to seek pleasure and avoid pain. Well, if youre eating and not paying attention, the brain will drive you to seek more pleasure via overeating. Whats worse, if youre stressed while eating, the excess cortisol in your system actually de-sensitises us to pleasure so youll need to eat more food in order to get the pleasure we are seeking. The bottom line is this: If you want more pleasure from food, you dont need to eat more of the ice cream. Simply breathe, relax, de-stress, enjoy, and pay attention and the body will naturally experience the pleasure it seeks. And the great news is, since pleasure catalyses a relaxation response, it actually fuels digestion and assimilation.

Emotional eating its not the enemyAt our core, we are emotional beings rich, complex, juicy, unpredictable, feeling-filled creatures. We love, we celebrate, we laugh, cry, we break down, we rise up So how could we NOT be emotional eaters? We love food. We love our favourite restaurant. We love how food makes us feel good. Some of us love cooking for others. Some of us are passionate about nutrition. Its time to get over it if youre human, you will bring emotionality to the table. Once we embrace the reality that were genetically hard-wired for emotional expression we can relax a little more. Underneath the quest to eradicate emotional eating from ones life is often found a hidden desire to eliminate uncomfortable feelings. We strive for the impossible; to attain goals that constantly leave us frustrated and in failure. Yes, this thing called emotional eating can be very painful. But its not the actual problem, its a symptom thats pointing to something deeper. Its an alert mechanism from our bodys wisdom thats calling us to check-in, and follow the flow of emotions within us to see where our soul is calling for more awareness and insight.

Get rid of toxic nutritional beliefsFinally, many of us have absorbed toxic nutritional beliefs that are as harmful and debilitating as any of the toxins in our food. Heres what I mean: its surprisingly common for people to believe that food is the enemy, or food makes me fat, or fat in food will become fat on my body or my appetite is the enemy or as soon as I have the perfect body, then Ill finally be happy. Such beliefs may seem harmless, yet they can create a relationship with food thats filled with tremendous suffering and pain. Think about it if food is the enemy, then we are constantly in a fight or flight stress response whenever we eat or even think about food. Such a powerful stressor can cause all the problems of a stress-induced digestive shutdown, decreased calorie-burning capacity, and an inner life thats seldom at peace. The question is: Is your relationship with food nourishing, or punishing?

Lets bring back the joy of food. And the more we include a well rounded nutritional profile Vitamin R relaxation, Vitamin P pleasure, Vitamin S slow, and Vitamin L love the more we can literally nourish ourselves on every level.

written by Marc David and adapted by Michele Chevalley Hedge, Published on A Healthy View

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Who We Are As Eaters? - Thrive Global


Mar 2

Getting fit to impact the world AU Health and Fitness has variety of programs – The Asbury Collegian

According to the Center for Disease Control and Prevention (CDC) in 2016, 71.6% ofAmericans were reported to be either obese or overweight. According to a study by theUniversity of Georgia, college students average 6.0-6.9 hours of sleep a night, even though 7-9hours is the recommended amount. But how does this impact Asbury? How can we respond tonationwide trends in poor health?Last semester, the Center for Wholeness and Wellness started a new program calledAsbury University Health and Fitness. The programs goal is to equip the Asbury community tobecome healthier mentally and physically while giving them lasting knowledge to help others.By equipping Asburians, we are better able to serve not just the United States, but theworld. The program has many opportunities for students, faculty, staff and the surroundingcommunity. Personal training, group fitness, fitness programs and wellness seminars are offeredduring the semester.The program is also more affordable than most personal training sessions, which cost aminimum of $40 per hour and can often cost as much $150 per hour. AU Health and Fitnesscharges $40 for the month for students; the cost includes two 45-minute sessions a week. In theend, you pay $5 a session.However, if personal training is too much, then find one of the free group exercise classesthat are on campus. Why should you exercise? Exercise helps us sleep more and feel happier. Italso decreases stress and chances of heart disease.1 Corinthians 6:19-20 says, Do you not know that your bodies are temples of the HolySpirit, who is in you, whom you have received from God? You are not your own; you werebought at a price. Therefore honor God with your bodies.God calls us to be healthy. We do not have to be bodybuilders or freak athletes, but weshould honor our bodies. One of Asburys mottos is Impact the world. How are we to impactthe world if we are not healthy?If we are to impact the world, we need to impact Asbury first. Change what the worldsays about health, and go against the grain. It starts here. Get educated and get healthy.

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Getting fit to impact the world AU Health and Fitness has variety of programs - The Asbury Collegian


Mar 2

North Hempstead recruits players to "Play Ball" – Community News – The Island Now

North Hempstead Town Supervisor Judi Bosworth, Council Member Veronica Lurvey and Town Board members, along with the Long Island Senior Softball Association are looking to form a new North Hempstead Senior Softball Team.

The team will be part of LISSA and is open to residents of North Hempstead, 60 years of age and over. The Town will be funding the teams costs, which will include umpire fees, league dues, and funding for jerseys for the teams members.

We encourage our residents to join North Hempsteads Senior Softball League and take advantage of this new and fun way of being active and spending time with your fellow neighbors, Bosworth said. This is just one of many senior exercise programs we offer in the Town.

The team will play 60 games beginning in 2020, 30 of which are home games and double-headers. The season will take place from May through September with games being played during the morning hours at a Town of North Hempstead park. Those selected to be a member of the North Hempstead team are required to remain with the team for two consecutive years.

We are thrilled to be able to follow up on this idea, brought to us by our residents. We are looking forward to bringing senior softball to North Hempstead and join our fellow Hempstead and Oyster Bay townships with a team of our own, said Council Member Lurvey.

The Town offers a wide variety of programs for seniors, including exercise classes, discussion groups, and meditation activities. The Senior Softball Team is an expansion in this programming, with the goal of giving seniors even more opportunities to remain active in North Hempstead.

Anyone interested can call the Long Island Senior Softball Association at 516-510-8341 or the 311 Call Center.

Submitted by the Town of North Hempstead

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North Hempstead recruits players to "Play Ball" - Community News - The Island Now


Mar 2

Health New England to award $50k to five community non-profits – WWLP.com

SPRINGFIELD, Mass. (WWLP) Health New England is launching a grant program aimed to advance the health and well-being of vulnerable groups in central and western Massachusetts.

According to a news release sent to 22News, the Where Health Matters grant is part of its Comunity Benefits Program that will be offered for the third year in a row! Grant applications are being accepted from March 2, through April 27.

Health New England will award five $50,000 grants totaling $250,000 to community non-profit organizations. The grant focuses on areas of health and social factors that influence health such as access to healthy foods, places to exercise, transportation, and care coordination.

We are pleased to continue our Grant Program in 2020 and acknowledge the importance of giving back to the community to help support the health needs of our most vulnerable community members.

We look forward to partnering with five local organizations that have strong community relationships and are committed to improving the health outcomes of our at-risk residents

The grant program will award both one-year and multi-year grants if the non-organizations meet the following:

Organizations meeting the request for proposal (RFP) criteria are encouraged to submit a Letter of Intent online by 5:00 p.m. on March 23, 2020. Complete Grant RFP applications are due by 5:00 p.m. on April 27, 2020. For more information, click here.

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Health New England to award $50k to five community non-profits - WWLP.com


Mar 2

Learn about the Mind, Body, and MS Connection During MSAA’s 2020 MS Awareness Month Campaign – The Trentonian

CHERRY HILL, N.J., March 2, 2020 /PRNewswire/ --The Multiple Sclerosis Association of America (MSAA) recognizes March as Multiple Sclerosis (MS) Awareness Month. For this year's campaign, MSAA is focusing on The Mind, Body, and MS Connection, addressing the integration of physical and emotional wellness strategies to improve MS symptom management and overall quality of life. MSAA invites the MS community to participate in various educational activities throughout the month of March, including:

To access information and resources provided by MSAA during MS Awareness Month, please visit the MS Awareness Month hub page at mymsaa.org/awarenessmonth.

MSAA's 2020 MS Awareness Month's The Mind, Body, and MS Connection campaign has been made possible by the generous support of Biogen, Bristol-Myers Squibb, and Genentech.

To learn more about MS Awareness Month and MSAA's scheduled activities, please contact Kaitlyn Gallagher, Public Relations & Marketing Coordinator at (800) 532-7667, ext. 122 or via email at kgallagher@mymsaa.org.

About MSAAThe Multiple Sclerosis Association of America (MSAA) is a national nonprofit organization and leading resource for the entire MS community, improving lives today through vital services and support. MSAA provides free programs and services, such as: a Helpline with trained specialists; award-winning publications, including MSAA's magazine, The Motivator; MSAA's nationally recognized website, featuring award-winning educational videos and research updates; S.E.A.R.C.H. program to assist the MS community with learning about different treatment choices; a mobile phone app, My MS Manager (named one of the best multiple sclerosis iPhone & Android apps by Healthline.com); a resource database, My MS Resource Locator; safety and mobility equipment products; cooling accessories for heat-sensitive individuals; educational programs held across the country; MRI funding; My MSAA Community, a peer-to-peer online support forum; a clinical trial search tool; and more. For additional information, please visit http://www.mymsaa.orgor call (800) 532-7667.

About Multiple SclerosisMultiple sclerosis (MS) is a disease of the central nervous system (CNS), which consists of the brain, optic nerves, and spinal cord. MS damages or destroys the protective covering (known as myelin) surrounding the nerves of the CNS, and can potentially injure the nerves as well. This damage causes reduced communication between the brain and nerve pathways. Common MS symptoms include visual problems, overwhelming fatigue, difficulty with balance and coordination, depression and cognitive issues, and various levels of impaired mobility. The prevalence of multiple sclerosis is estimated at nearly one million people nationwide and most people with MS are diagnosed between the ages of 15 and 50. MS is not contagious and researchers continue to look for both a cause and a cure.

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Learn about the Mind, Body, and MS Connection During MSAA's 2020 MS Awareness Month Campaign - The Trentonian


Mar 2

Beam Therapeutics Could See Over 40% Upside Despite Unlucky IPO Timing – 24/7 Wall St.

Beam Therapeutics Inc. (NASDAQ: BEAM) is not exactly a household name in corporate America. It may not even be a household name in the world of biotechnology and health care at this point. The company managed to come public in 2020 just in time to catch the coronavirus selling panic in the financial markets. After closing its $17.00 per share initial public offering of 12,176,471 shares, including the exercise in full by the underwriters of their 1.588-million share overallotment option, the quiet period has now ended and that means that the analysts who work for firms in the underwriting syndicate can begin coverage.

Beam raised $207 million in its IPO before deducting underwriting discounts, commissions and related offering expenses. All the shares in the offering were offered by Beam Therapeutics. After opening at $24.00 on February 6, Beams first-day closing price was $18.75, but the shares traded up to as high as $31.80 on February 12, which also was the date of its $29.20 closing high.

The analysts at its underwriting firms are quite positive, and they all have Buy or Outperform equivalent ratings for big upside ahead. Beam Therapeutics is a biotechnology outfit that is developing precision genetic medicines for patients suffering from serious diseases. The companys developing therapies treat sickle cell disease and beta-thalassemia, and it is also developing CAR-T cell therapies for pediatric T-cell acute lymphoblastic leukemia and pediatric acute myeloid leukemia. Beam also is developing therapies for glycogen storage disorder and for ocular and central nervous system disorders.

JPMorgan, Jefferies and Barclays acted as Beams joint book-running managers in its initial public offering, and Wedbush Securities acted as lead manager for its offering. Jefferies started coverage with a Buy rating and assigned a $32 target price, while Barclays started its coverage with an Overweight rating and the same $32 target price.

JPMorgan initiated coverage with an Overweight rating with a $31 target price. That report from analyst Eric Joseph called for multiple targets being focused with a first-to-market or a best-in-class potential in rare disease and oncology indications.

David Nierengarten of Wedbush Securities had a $32 target price along with its new Outperform rating. He sees Beam as an undervalued biotech, based on its differentiated and potentially best-in-class gene-editing platform of base editing. The company is believed to generate highly efficient and predictable single base-pair changes in genomic DNA in order to correct genetic disease and its current pre-clinical pipeline contains 12 programs across three delivery methods. Nierengartens report said:

These include therapeutic areas such as hematology (sickle cell disease and beta-thalassemia), oncology (ex vivo multiplex editing to create next-generation CAR-Ts for ALL and AML), liver diseases (alpha-1 antitrypsin deficiency and glycogen storage disorder type 1a), and ocular and CNS disorders (Stargardt disease). Delivery methods include electroporation (hematology and oncology), non-viral LNP delivery (liver diseases), and viral AAV delivery (ocular and CNS disorders). Notably, for each genetic disease program base editing could potentially allow a functional cure following one-time treatment, while for Beams oncology programs, we believe the ability to efficiently achieve multiplex editing without diminishing cell fitness makes base editing ideal for developing competitive allogeneic cell therapies.

Shares of Beam Therapeutics closed at $22.49 on Friday, so the average target price of $31.75 from these four reports would imply upside of 41%. Its shares were last seen trading up 1.3% at $22.78, with a $1.24 billion market cap.

By Jon C. Ogg

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Beam Therapeutics Could See Over 40% Upside Despite Unlucky IPO Timing - 24/7 Wall St.


Mar 2

Kelly Ripas Favorite TV Clip of All Time Features Her BFF, Anderson Cooper – WomansDay.com

When it comes to staying fit, Kelly Ripa has her go-to workouts, but she's always ready to test out something new. "I'll try anything," Ripa tells Woman's Day while promoting Persona, a personalized vitamin program. "I'm lucky, I host a talk show so we get a lot of weird, cockamamy exercise programs that pass through."

The weirdest program to pass through? An arial hoop workout. "We did it with Anderson Cooper, and I don't mind telling you, it's kind of my favorite moment on television ever."

Favorite TV moment ever is a pretty big claim, so when Ripa said, "You've gotta Google it," we did just that. And the clip does not disappoint.

It's four and a half minutes of Ripa and Cooper doing some (potentially dangerous) arial hoop maneuvers and pulling off varying degrees of gracefulness. Cooper begins the segment by saying, "This is a disaster waiting to happen," and it becomes increasingly clear how correct his claim is as the clip progresses. At one point, Ripa and the audience seem 97 percent sure that Cooper is about to fall off the hoop upside down and break his neck, and as Ripa says, "Oh my gosh, be careful! Be careful!" But Cooper laughs it off.

"He's just endlessly entertaining," Ripa says of Cooper, who she's previously stated has and will always be her unrequited love. "And if you get the opportunity to see him hang from a trapeze in the middle of a TV studio, just take it because it really is something everybody should get to experience once."

Our guess is that Cooper's steered clear of arial hoops since filming this, but for Ripa's sake we'll be sure to stop and watch if he ever takes one on again.

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Kelly Ripas Favorite TV Clip of All Time Features Her BFF, Anderson Cooper - WomansDay.com


Mar 2

Why CrossFit Is Going After Your Grandpa – menshealth.com

Video: Getty/Crossfit

SHIRTLESS, SWEATY AND extremely jacked: Over the past decade, thats been CrossFits public image, manifested at the Olympic-style CrossFit Games, which drew an estimated 11.6 million viewers in 2019 on its Facebook and YouTube livestreams alone. The finalists who go on to win that competitions centerpiece souped-up fitness circuits, filled with muscle-ups, power cleans, and burpees, epitomize the brands tagline of Forging elite fitness. (Yes, its trademarked.)

No men have represented that ideal better than Rich Froning and Mat Fraser four-time champs who are now in their early 30s with sponsorships from brands like supplement giant Cellucor (Fraser) and apparel company Reebok (Froning) and a combined 3.3 million followers on Instagram. Repeat female champs like Annie Thorisdottir and Tia-Clair Toomey have won their own share of fame and endorsementsand are equally rippling powerhouses. So why exactly is CrossFit Inc., the brands parent company, now putting its spotlight on old and (largely) less fit people?

In January 2019, the company started posting video tutorials for iconic workout moves on its website, Twitter feed, and YouTube channel starring anonymous men and women who appear to be in their 60s at least. One of the first, dubbed The Burpee, shows a balding, gray-haired, and relatively out-of-shape guy in a loose plaid button-up, baggy blue shorts, and hiking shoes executing the eponymous leaping, full-body conditioning move in real timeonly in what seems like slow motion: Rather than dive toward the ground, he simply kneels, lies down on his chest, and pushes himself back up.

The videos are part of CrossFits new At Home series, a mix of exercise tutorials and healthy recipes. Some of the videos are shot against a white background, while others are filmed on living room sets featuring dated furnishings. (Think wood paneling and drab floral couches.) The kettlebells and sandbags typical in traditional CrossFit workouts are replaced in these shoots with everyday home items, like jugs of blue-tinted water and a bag of pet food.

This is part of a dramatic change in CrossFits marketing, says Eric James, Ph.D., a professor of communication at Metropolitan State University of Denver. James studies organizational culture communication and wellness. He has done research on the way CrossFit presents itself, and views the current shift as a conscious departure from the brands public image, from an apostle of elite fitness to an advocate of accessible fitness and a crusader in the fight against inactivity and chronic illness. Convincing older folks, a huge and growing but often sedentary demographic, that CrossFit can work for them as well as it works for Froning and Fraser is a key goal of, and trial for, that transformative push.

Physical therapist Kelly Starrett, DPT, who founded San Francisco CrossFit, the brands 21st affiliate, in 2005, says he and many other trainers and affiliate owners have tried for years now to ensure that their gyms feel inclusive to older and less fit people. (CrossFit is highly decentralized. Affiliates are free to develop unique cultures and practices.) Many longtime CrossFit insiders, he says, welcomed this shift, feeling it was high time that HQ recognized and embraced the age and fitness diversity in its gymsor, as CrossFit calls them, "boxes" worldwide. But from the outside, he admits, you might think this is new or different or radical The juxtaposition suddenly caught people off guard [and] theres this perception of Wow, CrossFit has lost its mind.

Some CrossFit fans seem to feel the same way, given the number who have panned the videos in comments and taken to Reddit to vent their frustrations. I thought she had fallen and couldnt get up, one YouTube commenter quipped about a woman in a Thrusters and Planks tutorial. [This] is going to crash the CrossFit brand, a Redditor grumbled in a (top-rated) comment about the shift in general.

CrossFit founder Greg Glassman opened his first sparsely furnished box filled with no-frills equipment like barbells and flat benches to promote high-intensity workouts in 2000. Since then, the CrossFit movement has grown exponentially, reportedly encompassing more than 15,000 affiliates worldwide. But selling seniors on CrossFit, either out of an altruistic desire to help them live healthier lives or in a grasping bid to tap a huge new market of potential box goers, may be one of the brands hardest lifts yet.

THE "AT HOME" series message of accessibility is hard to square with Pukie the Clown, a cartoon character always pictured projectile-vomiting after a harsh workout. Or with his counterpart, Uncle Rhabdo, a muscular but haggard clown covered in lesions and hooked up to a dialysis machinebecause he worked out so hard that he developed rhabdomyolysis, a potentially fatal condition in which muscles are worked so hard they sustain damage severe enough to cause the fibers to break down, releasing cellular debris into the blood, which can cause permanent kidney, muscle, or nerve damage if left untreated. Some early CrossFitters claim Glassman invented the clowns in the early 2000s for use in CrossFit materials; Pukie is still seen in murals in a few boxes, as their unofficial mascot. (Mens Health reached out to CrossFit Inc. for this article but did not receive a reply by publication.)

Many CrossFit fans and critics alike believe Pukie glorifies pushing yourself so hard that you yarf, while Rhabdo makes light of the risks of over-exercising. Some insiders say the clowns are actually cautionary talesDont push yourself so hard, dont be a fool. Whatever the origins, both perpetuate a popular belief that CrossFit is all about going absolutely HAM and prioritizing progress over everything.

The truth is a little different. Glassman and his early collaborators built CrossFit to foster functional fitness through high-intensity workouts rooted in basic movements. The program centers on workouts of the day (WODs), each ostensibly focusing on a different type of core physical competency. (Like devotees of any club, CrossFit fanatics have their own vernacular, rich in abbreviations and code names. If youre new, the box finder tool Rounds for Time has posted a 71-term glossary.)

Doing a WOD as Rx'd (CrossFit speak for "as prescribed") involves completing sets of predetermined moves as quickly as possible within strict time limits. That alone might seem tough. But trainers can encourage competition by scoring your performance based on how many reps you got in before time ran out, which can make things even tougher. The Fran, one of a group of classic and consistently repeated benchmark WODs collectively known as The Girls, Rx'es 21 reps of 95-pound barbell thrusters followed by 21 pull-ups. Then 15 barbell thrusters and 15 pull-ups. Then nine thrusters and nine pull-ups. Beginners with a good time are supposed to complete a Fran in seven to nine minutes, while elite athletes are expected to nail it in under three. Thats a tall order for many casual athletes, much less older folks who are affected by age-related muscle loss and any number of other subtle to serious physical limitations.

But there is a tweak: The CrossFit regimen allows practitioners to scale WODs, using lighter weights or easier versions of motions as needed to maintain form and safety. CrossFit still encourages people to push their limits. But scaling allows them to set their own pace. As early as 2002, in an article in CrossFit Journal, CrossFit Inc.s official magazine, Glassman explained how scaling creates space for seniors to work out comfortably in boxes alongside elite athletes. The needs of an Olympic athlete and our grandparents differ by degree not kind, he wrote. One is looking for functional dominance, the other for functional competence We have used our same routines for elderly individuals with heart disease and cage fighters one month out from televised bouts. We scale load and intensity; we do not change the programs.

Some trainers take that to heart. Four of the half-dozen CrossFit trainers I spoke to for this story said they had relatives over the age of 65 who had been involved in their local CrossFit boxes for years. Recently, boxes have started establishing and sharing tactics for integrating older or less experienced individuals into their communities, at times by creating special programs. Most of the gyms Ive gone to, and that would be in the hundreds, have masters programs, says Starrett, using a general fitness-world term for over-40 athletes. And really senior athletes, he adds.

Even the CrossFit Games, launched in 2007 with no age brackets, had created an explicit over-60-athletes category by 2011. The 19 men who competed in this category did an Rx workout of 500 meters of rowing, 500 meters on a bike, 15 burpee box jumps, and a 120 foot carry, but in an age-scaled time frame.

THE FIRST PEOPLE Glassman focused on bringing into the CrossFit fold in the early 2000s were mostly police officers, other first responders, and military types. He reportedly built a lot of CrossFits early rhetoric and imagery around their hardcore, tough-guy vibePukie and Rhabdo were allegedly born out of their dark humor. So the CrossFit regimen may have in theory been inclusive and accessible, but the public image was incredibly niche, and likely unappealing to many seniors.

But according to Chris Cooper, a former CrossFit media-team member and current box operator and gym business mentor, this was all part of a grand plan. Glassman often talked, he says, about starting with the SEALs and then work on the grandmothers. The idea being that bringing in elite athletes first would eventually allow him to show people, through arguably extreme examples, that CrossFit worked. From a marketing perspective, thats really a one-way street: Once you get enough shirtless icons aboard, average people might sign up too because they want some version of that muscle-bulging jacked-ness. But on the flip side, elite athletes probably wouldnt want to sign up for a newfangled program targeted at average folks precisely because the more malleable and accessible you make something, the more the gains might vary.

Thats how the Games startedas a test kitchen where we can prove our concepts, as Starrett puts it. But Starrett and others suggest that the Games wound up becoming far more central to CrossFits public brand than Glassman may have intended, thanks to snowballing media coverage and popular interest. The brand certainly leaned hard into the Games' vision of physical exceptionalism at times seemingly to the exclusion of openness and accessibility. In 2009, the editors of the CrossFit Journal ran a small piece titled Iron Will, Iron Bodies alongside a series of photos of chiseled athletes straining with effort at that years Games. It read, in part:

Starrett says that the Games ultimately became a distraction to affiliates trying to bring in an older clientele. While seeing people perform Herculean feats might be great entertainment, at a certain point it perhaps becomes a turn-off to average people. Especially if theyre past their prime and worried about having to get in sufficient shape to even try the workout. CrossFit's "At Home video series sets a fundamentally more approachable tone, right down to the soothing elevator music, with plenty of different ways to get started. There are now more than 100 exercise videos in the playlist.

The public debut of that programming might have seemed sudden, but CrossFit Inc. has been working for a while now on several ways to become all-ages accessible. Three years ago, the company published training materials on how to work with masters athletes, making it easier for boxes to develop competitive programs for the slightly older set on their own. And two years ago, Glassman started offering MDL1 courses, a version of the intro (or L1) two-day training course required to be a certified CrossFit trainer geared explicitly towards medical doctors. Glassman, who is now 63 and going strong, seems to be betting this will improve their knowledge of his version of functional fitnessand potentially get them to refer less fit or older patients to CrossFit boxes for their health.

But this shift has not necessarily prepared individual CrossFit affiliates to work with the older people. Early on, CrossFits masters training appeared to be a work in progress. A CrossFit Journal article, Functional and Fit over 50, published a few months before the training materials came out, all but tells affiliates to just figure out how to work with older populations on their own. A few members of the CrossFit community have criticized their peers for being too rosy and glib about the supposed ease of working with seniors, many of whom have a number of physical restrictions that trainers need to know how to deal with. This stacks onto longstanding critique from more-traditional trainers that CrossFit does not require nearly enough instruction for its own trainers and simultaneously gives affiliates extreme autonomy to work with clients however they see fit within their own fiefdoms. Their more oblique message seems to be that doing CrossFit is somehow risky, although there is no evidence that the format causes injury.

Axel Pflueger, M.D., Ph.D., a New York City-based doctor, teaches his clients CrossFit routines in his office to help them stay fit. He served as CrossFit Inc.s chief medical officer from 2016 to 2018 and says he still acts as a medical advisor to Glassman. But Pflueger says there are few boxes to refer his older patients to for ongoing support and training. He knows that some boxes have a long history of working with seniors and acknowledges that many trainers seem to want to be able to work with his patients, in keeping with CrossFits core accessibility ethos. But in the grand scheme, he thinks few are fully prepared for the task. Sometimes there is a hesitancy from the coaches, like, Oh my God, heres a 65-year-old. What am I getting into? he says.

THE PROPOSITION OF attracting more seniors to gyms certainly looks like a savvy business move. People over 60 have the most free time, notes Roland Sturm, Ph.D., a RAND Corporation economist who analyzes health and wellness trends, and much of that is in the late morning or the afternoon, typical gym downtimes. Not everyone may be willing to dip into their retirement savings for a CrossFit class. But Jon Levell, a co-owner of CrossFit by Overload, a box in Murrieta, California, showed last year that they dont necessarily need to pay their own way.

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Through his other job as a business manager at the Loma Linda University Medical Center, Levell and another CrossFit client and enthusiast, who also worked at a local health-care group, Rancho Family Medical, teamed up to add seniors to their list of acceptable reimbursements. He now runs three 10:30 A.M. classes per week, specially scaled for seniors, for about 60 participantsand hopes to move up to five a week soon. Thanks to the programs visibility, he adds, Ive had [older] people come in and say, I dont have that medical benefit, but Id still like to [participate], and they pay full freight.

When implemented safely and correctly, Levell says that creating a program like his can attract a revenue stream that has been untouched by other gyms. Maybe so. But that only matters if you can convince seniors to show up in the first place. According to the federal American Time Use Survey, Strum says, only about 2.5 percent of older people go to a gym on a typical day. (For perspective, thats less than half the rate for people between the ages of 15 and 25.) Seniors prefer to work out at home, or by walking around their neighborhoods, if at all. Giving them video guides to doing scaled-down CrossFit workouts they can do in their living rooms may help to demystify the movement, but thats only a starting point. And while Levell has had some success, he admits that hes struggled to find other boxes willing or able to adopt his program. Concerns about trainer preparedness are still big deal. The minute one 70-year-old has a heart attack or breaks their femur, he says, you know all kinds of bad vibes and publicity are going to get behind it.

Regardless, James, the Denver-based marketing researcher, believes that this new wave of senior-friendly tutorials ultimately still sends older people an important message: That its okay for everyone to pursue their own individual health goals, rather than some prescribed (or RX'd?) notion of the fitness ideal for all. That could actually get more older folks into health and exercise, even if its in the comfort of their own home and even if they dont end up following CrossFits routines specifically.

One year in, the comments on more recent videos seem generally more upbeat and the makeshift exercise tools have achieved their own cult status. I would like to see the water jugs, someone jokingly posted on a YouTube video uploaded in mid-February featuring a woman doing lunges without weights. Within a week, two more tutorials involving the now famous jugs went live.

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Why CrossFit Is Going After Your Grandpa - menshealth.com


Mar 2

Research by App State alumna shows ankle injuries can be treated by targeting the brain – Appalachian State University

BOONE, N.C. Research conducted by Amelia Bruce 19 while a graduate student at Appalachian State University suggests ankle injuries can be better treated by targeting the brain. The results of this groundbreaking study have been published in the February issue of Medicine and Science in Sports and Exercise, the official journal of the American College of Sports Medicine.

Bruce, who is from Taylorsville, earned an M.S. in exercise science from Appalachian and is currently pursuing her Ph.D. in kinesiology at the University of Virginia.

While clinicians primarily treat the musculoskeletal side (during the rehabilitation phase), there is a whole neural system that is impacted by these injuries and needs just as much attention during treatment.

Appalachian alumna Amelia Bruce 19 on her research into treating ankle injuries.

While at Appalachian, Bruce worked with Dr. Alan Needle, associate professor in the Beaver College of Health Sciences Department of Health and Exercise Science. Needles previous research had shown the brains of people with ankle instability need more brain activation to do simple tasks. Bruce took the lead with the next step, testing the impact of brain stimulation in treating ligamentous injuries.

Appalachian alumna Amelia Bruce 19, standing, prepares a study participant in order to measure the effect of brain stimulation on treating ankle injuries. Photo submitted

Highlights of the study:

This topic was of importance to me because injuries in ligaments happen every day. If this intervention worked, it could reshape how clinicians treat these types of injuries during the rehabilitation phase, Bruce said.

While clinicians primarily treat the musculoskeletal side (during the rehabilitation phase), there is a whole neural system that is impacted by these injuries and needs just as much attention during treatment, she added.

When a sprain occurs in ankle ligaments, the brain directs the body to compensate by changing the patients gait, Bruce explained. This subconscious compensation causes a weakness in the ankle that leads to recurrent sprains over a patients lifetime potentially leading to inactivity and related obesity, cardiovascular disease and other health problems.

We want to nip that in the bud before it gets to that point by changing the way the brain reacts to the injury, Bruce said.

Amelia Bruce 19, a 2019 graduate of Appalachians M.A. in exercise science program from Taylorsville. Photo submitted

Bruce presented her research findings at several conferences, including the following:

Bruce plans to continue her research at the University of Virginia by testing patients with knee ligament injuries.

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The Master of Science degree in Exercise Science prepares qualified professionals for employment in athletics programs, exercise/fitness centers and other locations, or for advanced study. Students can choose one of three concentrations: Research, Clinical Exercise Physiology, and Strength and Conditioning.

May 3, 2019

Undergraduates Bryson Honeycutt, Carly Maas and John Stevens IV, along with graduate students Amelia Bruce, Liz Derrick and Tom Hastings, were recognized as the winners of the celebrations 10th Student Poster Competition.

The Department of Health and Exercise Science in Appalachian State Universitys Beaver College of Health Sciences delivers student-centered education that is accentuated by quality teaching, scholarly activity and service. The department includes two undergraduate academic disciplines: exercise science and public health. The department also offers two masters degrees: athletic training, which leads to professional licensure, and exercise science, which prepares students for advanced study in a variety of related fields as well as research. Learn more at https://hes.appstate.edu.

Appalachian's Beaver College of Health Sciences opened in 2010 as the result of a strategic university commitment to significantly enhance the health and quality of life for individuals, families and communities in North Carolina and beyond. In 2015, the college was named for an Appalachian alumnus and pioneer in the health care industry Donald C. Beaver 62 64 of Conover. The college offers nine undergraduate degree programs and seven graduate degree programs, which are organized into six departments: Communication Sciences and Disorders; Health and Exercise Science; Nursing; Nutrition and Health Care Management; Recreation Management and Physical Education; and Social Work. Learn more at https://healthsciences.appstate.edu.

Appalachian State Universitys Cratis D. Williams School of Graduate Studies helps individuals reach the next level in their career advancement and preparedness. The school offers 70 graduate degree and certificate programs in a range of disciplines, including doctoral programs in education (Ed.D.) and psychology (Psy.D.). Classes are offered at the main campus in Boone as well as online and face-to-face at locations around northwestern North Carolina. The graduate school enrolls nearly 1,800 students. Learn more at https://graduate.appstate.edu.

As the premier public undergraduate institution in the state of North Carolina, Appalachian State University prepares students to lead purposeful lives as global citizens who understand and engage their responsibilities in creating a sustainable future for all. The Appalachian Experience promotes a spirit of inclusion that brings people together in inspiring ways to acquire and create knowledge, to grow holistically, to act with passion and determination, and to embrace diversity and difference. Located in the Blue Ridge Mountains, Appalachian is one of 17 campuses in the University of North Carolina System. Appalachian enrolls more than 19,000 students, has a low student-to-faculty ratio and offers more than 150 undergraduate and graduate majors.

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Research by App State alumna shows ankle injuries can be treated by targeting the brain - Appalachian State University



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