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For information, visit dovertownlibrary.org, or call 508-785-8113.

The Dover Town Library, 56 Dedham St., is open Mondays, Tuesdays and Wednesdays from 10 a.m.-8 p.m.; Thursdays and Fridays from 10 a.m.-6 p.m.; Saturdays from 10 a.m.-4 p.m.; and closed on Sundays. For information, visit http://www.dovertownlibrary.org, or call 508-785-8113.

Find us on Facebook and Twitter.

Holiday closings: The library will close at 1 p.m. on Dec. 24, and remain closed on Dec. 25 for the Christmas holiday. The library will close at 3 p.m. on Dec. 31, and remain closed on Jan. 1, for the New Years holiday.

Adult & Family Programs

Qigong

Every Monday from 5:30-6:30 p.m.

Qigong is a practice of aligning breath, movement, and awareness for exercise, healing, and meditation. This program is sponsored by the Dover Council of Aging.

Oodles of Doodles

Every second and fourth Tuesday of the month from 1:30-3 p.m.

Join us for some art therapy at this adult coloring session. Supplies and space provided.

Virtual Reality Freeplay

Every Thursday from 3-5 p.m.

Every Saturday from 1:30-2:30 p.m.

Come to the library to try out the HTC Vive virtual reality headset. Test out a variety of games and simulations such as The Blu, Space Pirate Trainer, Job Simulator, and The Lab. Due to popular demand, we are now offering Virtual Reality on Saturdays, too! Open to ages 10 and up.

Caregivers Support Meeting

Every Tuesday from 11 a.m.-noon

Every Friday from 1-2 p.m.

Caregiving is a tough job. The journey often feels overwhelming and lonely. If you are a wife, husband, parent, or a friend who offers care to an Alzheimers patient or a patient with a long-term health challenge/trauma, Dover Town Library would like to offer you a safe space to refresh, have coffee, chat, and meet with friends.

3D Printing Workshop

Tuesday, Jan. 7, 6-7 p.m., Community Room

Learn the basics of Computer Aided Design using tinkerCAD.com. This hands-on class will go over the basics of creating 3D models that can be turned into real objects with a 3D printer. A basic understanding of computers is necessary.

Childrens Programs

Super Awesome Fun Time

Mondays from 4-5 p.m.

Thursdays and Fridays from 10:30-11:30 a.m.

A super, awesome, fun time for kids ages 10 months to 6 years with stories, songs, activities, and crafts. Space is limited. Please pick up tickets at the Childrens Room desk, starting 30 minutes before the program begins.

For more information, please contact Angie Howes by phone at 508-785-8113 or via e-mail at ahowes@doverma.org

Excerpt from:
Programs at the Dover Town Library - Wicked Local Melrose

UGA study to examine why that's happening and how to improve the statistics

Rural communities experience more deaths each year related to poor cardiovascular health compared to city dwellers, and that gap is widening.

Now, a team of researchers from the University of Georgia and the Icahn School of Medicine at Mount Sinai are using a new, robust form of computer modeling to find ways to reduce this urban-rural divide in Georgia and New York.

The project, supported by a $1.5 million grant from the National Institute on Minority Health and Health Disparities, will use agent-based modeling to simulate the impact of real-world policy interventions. It is the first to collect data and simulate policies at the county and state levels.

Agent-based modeling was first developed to assess food environments in urban settings, said Donglan Stacy Zhang, project leader and assistant professor in UGAs College of Public Health.

The model takes into account many factors that influence individuals health behaviors, including sociodemographic factors, the local environment, and personal preferences and beliefs.

Zhang saw a need to adapt the model to work for rural and often resource-poor areas.

The places that need evidence-based policy simulations the most are areas with limited resources, she said. Rural areas do not have the resources that many urban communities have, so given scarce resources, they have a higher need for evidence to help guide their policy decisions.

Increasingly, systems science and simulation modeling are playing an important role in the selection and implementation of policies and interventions to help people improve their overall health.

Health is determined by more than individual choices, said Zhang. There is a system of clinical and community factors that contribute to cardiovascular health.

For example, provider shortages and the ability to pay for health care affect a persons access to regular care, while their community environments, such as access to heart-healthy foods and safe places to exercise, also shape lifestyle and overall health.

A model can help us understand the whole system and understand the interplay of complex factors, said Zhang.

Zhang and UGA public health collaborator Janani Thapa, recently published a study showing that the agent-based model could be successfully translated to rural communities, laying the groundwork for this larger, more ambitious study.

The current project is collecting data from federal, state and local sources, including from the Centers for Disease Control and Prevention, medical claims records, existing cohort risk scores, and local community organizations.

The focus on local data and outcomes is the unique feature of the teams simulation model, said Zhang. Many existing models with a national-level focus, she explained, are less useful in informing local policies and interventions.

Most interventions are implemented at the community level. Its really important for us to understand the local population characteristics and local environment in order to tailor interventions and improve the health of these communities, she said.

The team will evaluate the impact of improved health care delivery and community-based public health interventions on cardiovascular health. Such interventions include home telehealth for diabetes monitoring, insurance copayment reductions for highly valued services,increasing access to fresh produce, increasing tobacco excise taxes, and diet and physical activity promotion programs, said Zhang.

The investigators also want to examine the different political and economic climates that may shape health outcomes in Georgia and New York.

The two states have very different economic conditions and political values, said Zhang. So, we will look at the variation in the impact of the same policy on populations in both states.

The team has begun collecting data and will be running their first simulations in the coming months. The team members plan to roll out their findings and policy recommendations to local community leaders and state and federal policymakers throughout the four-year project.

The full project team includes Donglan Stacy Zhang, Yan Li, Janani Thapa, Lan Mu, Zhuo Adam Chen, Andrew Moran and Jos Pagn.

See the article here:
Cardiovascular deaths are higher in rural areas - University of Georgia

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Feb. 14, 2018, began like any other day for Kai Koerber. He was running late for his early morning AP English class at Marjory Stoneman Douglas High School in Parkland, Florida. When he got there, he was handed the classs biggest assignment of the year and groaned. At the time, I was like, Man, this is going to be the worst part of my day,' says Koerber, now a first-year student majoring in computer science at UC Berkeley.

After English, he had honors chemistry, followed by pre-calculus, then guitar class in the band room. At 2:18 p.m., he asked to use the restroom, but another classmate was out, so his teacher told Kai to wait. Two minutes later, the fire alarm went off. And what followed was a tragedy that his school would become known for one that Kai would decide to speak out about, changing the narrative about the impact of gun violence on youth in the United States.

At Berkeley, in between classes and studying, Kai works to promote his nonprofit and mental health curriculum something that hes become passionate about since surviving one of the deadliest school shootings in the country.

Kai Koerber is a first-year student majoring in computer science at Berkeley. (UC Berkeley photo by Brittany Hosea-Small)

[Music: Highride by Blue Dot Sessions]

Narration: It was Feb. 14, 2018. Valentines Day. Like most days, Kai Koerber was running late to AP English. To be fair, the class was at 7:30 in the morning, which, to me, seems absurdly early for a high school class.

Kai at 6 months old with his mom, Alana. Before Kai enrolled in high school, his family moved from New Jersey to Florida so that Kai and his two younger sisters could get a better education. (Photo courtesy of Alana Koerber)

But thats how it was at Marjory Stoneman Douglas High School in Parkland, Florida. It was known for rigorous classes that set students up to attend the best colleges. And Kai, whose family had moved from New Jersey so that he and his two younger sisters could get a better education, was determined to make the most of it.

And it paid off. After he graduated, he got into UC Berkeley, where hes now a first-year student majoring in computer science.

What Kai didnt know that day about his high school was that it would also become known for a national tragedy one that he would decide to speak out about, changing the narrative about the impact of gun violence on youth in the United States.

Youre listening to Fiat Vox, a Berkeley News podcast. Im Anne Brice.

Narration: When Kai got to AP English, his teacher handed him the classs biggest assignment of the year a 20-page rhetorical analysis essay.

Kai Koerber: At the time, I was like, Man, this is going to be the worst part of my day. But, you know, as the day went on, obviously that wasnt the case.

Narration: Next, he had honors chemistry, followed by pre-calculus, then guitar class in the band room his most relaxing class of the day.

At 2:18 p.m., he asked his teacher if he could go to the restroom. But one of his classmates was already out, so the teacher told Kai to wait until the student returned.

Kai Koerber: I feel like thats divine intervention, almost. I cant think of any other way to explain that, really.

Narration: Two minutes later, at 2:20 p.m., the fire alarm went off. Kai and all the other students were evacuated to a grassy field. No one was really worried. They figured it was just another emergency drill, like they had from time to time.

[Music: Zither Sprak by Blue Dot Sessions]

But one student, whom Kai says was known as the class hypochondriac, said he heard gunshots. The other students kind of laughed it off and told him to relax.

Turns out, though, that time he was right.

Within minutes, the teachers had gotten word that there was an active shooter somewhere on campus. Everyone ran back inside to take cover.

Kais teacher locked the band rooms steel doors, covered the windows and turned off the lights. Students did their best to hide in closets and behind tables.

Kai Koerber: Nobody really knew where this person was. Nobody really knew what they were armed with, what they were doing, what they were capable of. At the time, we felt like sitting ducks.

Narration: Huddled in a closet, Kai texted his parents.

Kai Koerber: I remember texting them, like, Dont call me, because I dont want them to hear if theyre in the building. If they hear that someones on the phone, that could be it for all of us. I just kept saying, I love you, and Ill see you again later. Things like that.

When Kais mom, Alana, saw that her son sent her a text on Feb. 14, 2018, she didnt think anything of it at first. But when got a moment to read it, her heart sank. (Photo courtesy of Alana Koerber)

Narration: Kais mom, Alana Koerber, was driving on the freeway when she got his text. At first, she assumed it was just one of her sons everyday texts, asking if she was picking him up from school that day.

But when she got a moment to glance at her phone, she froze.

Alana Koerber: It said, Hey, Mom. Something is happening at my school. Im not sure, but I just want to let you know that if anything happens to me, that I love you. Im like, What does he mean, If anything happens to me, just know that I love you? That just made my heart drop.

Narration: By then, she was driving on the highway. Police cars with sirens blaring began to fly past her.

Alana Koerber: And Im like, Oh, my God! I just started shaking, like panicking, just not understanding. Like, Oh, my God, something is happening! What is happening?

Narration: She called the Coral Springs Police Department. They told her there was an active shooter on the schools campus, and that they didnt have any more information.

Alana headed straight for the school, parked and ran across the street to join a group of parents. The sheriff was there. Helicopters were landing on the baseball field. SWAT teams were rolling in, and huge ambulances were racing to the scene.

Alana Koerber: And Im like, Oh, my God! Oh, my God! Oh, my God! I dont care. I want to go. Why the hell are you guys all out here? All these cops are out here. You need to be in there where the kids are to save our kids. And then, the parents around me start to receive videos of dead bodies, blood. Theyre passing their phones around. Theyre passing these videos around. And its a group of like 30, 40, 50 parents.

The crowd is growing, and were starting to cry and hug each other because our kids are still in that school. And now we have videos of dead bodies. I was praying to God. I was just saying, God, please, please, please, please God. I dont know what I have to do. I dont know what I have to sacrifice. I dont know what I have to give up. But, Lord, please get my son out of there.

[Music: Lunette by Blue Dot Sessions]

Narration: Back in the band room, Kai was doing his best not to panic. Of course, just like most students in the school, he didnt know what was going on who and where the shooter was, if anyone had been hurt, if that day would be his last.

But he did know how to stay calm through stressful situations.

Kai Koerber: I tried my best to not think the worst. When I was really stressed out in certain situations, my family always told me to picture myself being safe at all times, no matter how dangerous the situation actually is. Its really gotten me through some rough times and kept me safe in a lot of different ways.

Alana Koerber: You know, I taught my son how to metaphysically protect himself, surrounding himself with white light, picturing wings of an angel, just soothing him from harm.

After the shooting, Kai wasnt sure he wanted to do interviews with the media. But after talking it over with him mom, he decided it was important that he speak out about the impact of gun violence on youth. (Photo courtesy of Alana Koerber)

Narration: So, Kai sat perfectly still in a corner of a closet, imagining himself surrounded by a bright protective light.

And Kai and his mom say that it worked that day. He was protected. If Kais teacher had let him go to the bathroom at 2:18 p.m., like hed asked, he would have been in the exact hallway at the exact time the gunman began shooting.

After about three hours, the high school was taken off lockdown, and students were allowed to go home.

It wasnt for another day or so that Kai would learn, along with the rest of world, that 17 people had been killed 14 students and three staff members making it one of the deadliest school shootings in the country. The killer was Nikolas Cruz, a former student at the high school.

[Music: Fifteen Street by Blue Dot Sessions]

Kai would go on to become an influential voice in the fight against gun violence. He did dozens of interviews with national news shows, radio programs and magazines. He attended protests and rallies, where he spoke to reporters whenever they had questions.

It was his responsibility, he says, to share his voice and try his hardest to make a difference in the way that mental health is understood and treated in the U.S.

Kai, 16, stands outside Stoneman Douglas High School in February 2018, days after the shooting. (Photo courtesy of Alana Koerber)

Narration: After the shooting, Kai wasnt sure he wanted to be in the limelight. Other Parkland students had begun appearing on TV, speaking out against gun violence and pushing for reforms in the country.

But Kai questioned if it was right. He wondered, Should they be putting themselves out there? Was it going to create positive change, or was it sensationalizing the tragedy?

He talked it over with his mom, and decided that he wanted to add his voice to the narrative to take a stand and speak authentically about gun violence and mental health, bringing the perspective of a young black person living in the South.

Kai appeared on the Daily Show with Trevor Noah with four other Stoneman Douglas High School students in March 2018. (Photo courtesy of Alana Koerber)

Here is he on the Daily Show with Trevor Noah with four other Stoneman Douglas High School students:

[Audio from the Daily Show interview:

Trevor Noah: Kai, on your side, giving teachers guns isnt the safe space that you would want to be in. A teacher having a gun doesnt make you feel better. Why?

Kai Koerber: If Im being honest, I dont want to seem like that guy, but me being a minority in the South and having a teacher with a gun does not make me feel comfortable. Even when you have resource officers who are taking matters into their own hands, I dont think lethal weapons should have a place in the school environment. If you need to have a weapon to defend people, I do believe it should be a non-lethal option.]

Narration: Kai soon became committed to promoting mental health curriculum in schools.

In April 2018, he founded Societal Reform Corporation, a nonprofit dedicated to supporting mental health programs in schools programs that teach students of all ages to mitigate emotions, relax, learn and grow as human beings.

He teamed up with the Crown Prince of Norway and Berkeley alumnus, Haakon Magnus, who runs a program called Global Dignity. He also partnered with a leading author on mindfulness and personal transformation, Jack Canfield. (Both Magnus and Canfield had seen Kai talk at different events and contacted him about a possible collaboration.)

Kai Koerber: I have found that a lot of people who are tremendously successful or who are in those positions do share a lot of the same beliefs that I do, in terms of how mental health works the power of intention, goal setting and not letting things stand in your way, no matter what they are. It seems to be a universal language to them.

Narration: Using both Magnuss and Canfields curricula, Kai has put together what he calls his Empowerment Curriculum some 400 pages of more than 100 lessons that he says will be a growing library of self-improvement resources.

Kai Koerber: It not only counters the culture of pharmaceutical dependence that America has, in terms of regulating emotional states, but it also teaches people that they dont need to depend on things outside of themselves to live happy and healthy lives.

[Music: Greylock by Blue Dot Sessions]

That was a really big part of my upbringing and I really wanted to share that and create a curriculum that reflected those beliefs.

Narration: A big part of the curriculum teaches mindfulness exercises that help to channel positive energy and mitigate negative emotions.

For one exercise, theres a script, but the idea is that someone might look in the mirror and say something like, I can overcome any obstacle standing in my way. By channeling the power of intention, it becomes a reality.

In Kais Empowerment Curriculum, theres a section that talks about how to use meditation to center yourself in a more positive reality something that Kai tries to do every day. (UC Berkeley photo by Brittany Hosea-Small)

Narration: Kai has already donated his curriculum to several school districts in Florida and to some alternative high school programs that help high-risk youth get their GEDs. Broward County Public Schools the sixth largest public school system in the nation is looking to incorporate some of its teachings into next years lesson plans.

As a student at Berkeley, Kai plans to major in computer science. Hes always loved math and finding solutions to problems, and his family has a long history in the field. His grandfather worked on Wall Street as a mathematical statistician. His uncle worked at NASA as a rocket scientist.

Kai Koerber: Its almost a right of passage to take calculus and all those classes. (laughs)

Narration: And when he has time between classes and studying, hes speaking at events across the country about mental health and the impact of gun violence on youth.

Kai says hes always loved math and solving problems. It runs in the family his grandfather was a mathematical statistician on Wall Street and his uncle worked at NASA as a rocket scientist. (UC Berkeley photo by Brittany Hosea-Small)

In November, Kai was the keynote speaker at the Florida Gulf Coast University, Children and Youth Mental Health Conference, where he received a standing ovation after leading several exercises from his curriculum with the audience.

And earlier this month, Kai spoke at an informational hearing chaired by California Assembly Member Buffy Wicks in Oakland. He was one of more than a dozen witnesses who testified on the impact of gun violence at the California Assembly Select Committee on Youth Mental Health.

[Music: Dirty Wallpaper by Blue Dot Sessions]

Kai says, ideally, he would like to see some of the lessons in his curriculum be used in high schools right away. The lessons on goal-setting and self-improvement, he says, are essential for students as they enter more challenging chapters of their lives. Eventually, he hopes the curriculum will be incorporated into all levels of education, from elementary school to college.

Kai knows its not going to be easy, but thats never been a roadblock before. When people tell him to consider other options or to think about what could happen if something failed, he says he doesnt have the energy or time to waste.

Kai with friends Mohammed Zareef Mustafa (left), Tijaan Issah Henderson (center) and Sundiata Chaka Teooem (right) at Crossroads Dining Hall, where Kai eats most of his meals. (UC Berkeley photo by Brittany Hosea-Small)

Kai Koerber: You just keep moving forward. You know, people, theyre very confused by that belief. But I dont know. Its something that I grew up with and its something thats worked for me as a student, as an entrepreneur and as a person. So I think Ill carry it with me for the rest of my life.

Narration: Kai continues to build new partnerships to grow his curriculum. He recently secured partnerships with two neurotechnology companies that create devices for focus, relaxation and guided meditation. He hopes to install neurotech lounges on campus that use real-time biofeedback to promote relaxation and focus.

At only 18, Kai has already accomplished a lot, but I have a feeling, its just the beginning.

For Berkeley News, Im Anne Brice.

To learn more about Kais nonprofit, Societal Reform Corporation, visit societalreform.org/. If you work at a school or for an after-school program and are interested in using the Empowerment Curriculum, email info@societalreform.org.

Subscribe to this podcast, Fiat Vox, on Apple Podcasts or wherever you listen. If you liked this episode, consider sharing it with a friend. And check out our other podcast, Berkeley Talks, that features lectures and conversations at UC Berkeley. You can find all of our podcast episodes on Berkeley News at news.berkeley.edu/podcasts.

(UC Berkeley photo by Brittany Hosea-Small)

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After Parkland shooting, student fights for mental health resources in schools - UC Berkeley

Collaboration Combines GBTs Therapeutic Area Leadership with Power of SyrosGene Control Platform to Find New Medicines to Induce Fetal Hemoglobin

Syros to Receive $20 Million Upfront, Three Years of Preclinical Research Fundingand Milestone Payments

SOUTH SAN FRANCISCO, Calif. and CAMBRIDGE, Mass., Dec. 18, 2019 (GLOBE NEWSWIRE) -- Global Blood Therapeutics, Inc. (GBT) (GBT) and Syros Pharmaceuticals, Inc. (SYRS) today announced that they have entered into a collaboration to discover, develop and commercialize novel therapies for sickle cell disease (SCD) and beta thalassemia. Under the agreement, Syros will use its leading gene control platform to identify therapeutic targets and discover drugs that induce fetal hemoglobin, and GBT will receive an option to obtain an exclusive worldwide license to develop, manufacture and commercialize products resulting from the collaboration.

The discovery and development of novel therapeutic approaches to treat sickle cell disease has been a driving force for GBT since we were founded, said Ted W. Love, M.D., president and CEO of GBT. We believe that Syros approach to inducing fetal hemoglobin is one of the most promising ways to identify the next generation of therapies to treat sickle cell disease and beta thalassemia at a fundamental level upstream of serious complications such as organ damage, organ failure and early death. We will continue to seek the best scientific approaches to transform the treatment of these devastating lifelong diseases.

Using its gene control platform to elucidate mechanisms controlling gamma globin gene expression, Syros identified components of LRF (leukemia/lymphoma-related factor) and the NuRD (nucleosome remodeling and histone deacetylation) complex that could serve as potential targets to switch on the gamma globin gene, which is normally silenced a few months after birth. By turning on gamma globin expression, GBT and Syros aim to induce the production of fetal hemoglobin, which is known to exert protective effects on the red blood cells of patients with SCD and beta thalassemia and mitigate the clinical manifestation of these diseases.We believe it is possible to provide a functional cure for patients with sickle cell disease or beta thalassemia by switching on the gamma globin gene with an oral medicine, said Nancy Simonian, M.D., CEO of Syros. Partnering with GBT, an established leader in sickle cell disease with proven research, development, manufacturing and commercialization capabilities, allows us to expand and accelerate our program, exploring multiple approaches in parallel with the aim of bringing much-needed new therapies to market for patients with sickle cell disease and beta thalassemia as quickly as possible.

Syros drug discovery program in SCD was highlighted recently in an oral presentation at the 61st American Society of Hematology (ASH) Annual Meeting, as well as in an ASH press briefing. In that presentation, Syros described its discovery of a fetal hemoglobin repressor that, when knocked down in primary cells and an erythroid cell line expressing adult hemoglobin, induced fetal hemoglobin in nearly 100% of cells and increased total fetal hemoglobin levels to 40%, exceeding levels that are associated with a functional cure in SCD patients.

Terms of the AgreementUnder the terms of the agreement, GBT will pay Syros $20 million upfront and fund up to $40 million in preclinical research for at least three years. Should GBT exercise its option under the agreement, Syros could receive up to $315 million in option exercise, development, regulatory, commercialization and sales-based milestones per product candidate and product resulting from the collaboration. Syros would also receive mid- to high-single digit royalties on sales of products resulting from the collaboration. In addition, Syros would have the option to co-promote the first product resulting from the collaboration in the United States.

About GBTGBT is a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. Founded in 2011, GBT is delivering on its goal to transform the treatment and care of sickle cell disease (SCD), a lifelong, devastating inherited blood disorder. The company has introduced Oxbryta (voxelotor), the first FDA-approved treatment that directly inhibits sickle hemoglobin polymerization, the root cause of SCD. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. In addition, GBTs drug discovery teams are working on new targets to develop the next generation of treatments for SCD. To learn more, please visit http://www.gbt.com and follow the company on Twitter @GBT_news.

Story continues

About Syros PharmaceuticalsSyros is redefining the power of small molecules to control the expression of genes. Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. Syros is advancing a robust pipeline of development candidates, including SY-1425, a first-in-class oral selective RAR agonist in a Phase 2 trial in a genomically defined subset of acute myeloid leukemia patients, and SY-5609, a highly selective and potent oral CDK7 inhibitor in investigational new drug application-enabling studies in cancer. Syros also has multiple preclinical and discovery programs in oncology and monogenic diseases, including sickle cell disease. For more information, visit http://www.syros.com and follow us on Twitter (@SyrosPharma) and LinkedIn.

Forward-Looking StatementsCertain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995, including statements containing the words will, anticipates, plans, believes, forecast, estimates, expects and intends, or similar expressions. These forward-looking statements are based on the current expectations of GBT and Syros, and actual results could differ materially. Statements in this press release may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. GBT and Syros each intend these forward-looking statements, including statements regarding the ability of the parties to discover, develop and commercialize novel therapies for SCD and beta thalassemia under the collaboration, the scientific and therapeutic potential of Syros gene control platform and approach to inducing fetal hemoglobin, the exercise by GBT of its option under the collaboration agreement, the potential milestone payments and royalties due to Syros under the collaboration agreement, and Syros option to co-promote the first product resulting from the collaboration in the United States, to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Securities Exchange Act, and GBT and Syros make this statement for purposes of complying with those safe harbor provisions. These forward-looking statements reflect the current views of GBT and Syros about their respective plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the companies and on assumptions the companies have made. Neither GBT nor Syros can give any assurance that the plans, intentions, expectations or strategies will be attained or achieved, and, furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a variety of risks and factors that are beyond the control of GBT and Syros including, without limitation, the timing and progress of, and any data generated from, the parties research and development activities under the collaboration, and the amount and timing of resources devoted by each of the parties to activities under the collaboration, along with those risks set forth in GBT and Syros respective Annual Reports on Form 10-K for the fiscal year ended December 31, 2018, and most recent Quarterly Reports on Form 10-Q filed with the U.S. Securities and Exchange Commission, as well as discussions of potential risks, uncertainties and other important factors in the companies subsequent filings with the U.S. Securities and Exchange Commission. Except as required by law, neither GBT nor Syros assumes any obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.

Contact Information:

Global Blood Therapeutics (GBT)

MediaSteven Immergut650-410-3258media@gbt.com

InvestorsStephanie Yao650-741-7730investor@gbt.com

Syros Pharmaceuticals

MediaNaomi Aoki617-283-4298naoki@syros.com

InvestorsHannah Deresiewicz212-362-1200hannah.deresiewicz@sternir.com

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GBT and Syros Partner to Discover, Develop and Commercialize Novel Therapies for Sickle Cell Disease and Beta Thalassemia - Yahoo Finance

For seniors, health benefits of exercise extend to both physical and emotional well-being.

The new year is almost here, which has many people thinking about their resolutions. The most common one, perhaps not surprisingly, is to exercise more. And yet, research shows that very few people actually stick to that resolution, with a substantial number giving up by mid-January.

But not everyone is throwing in the towel quite so quickly. Among those who get to the gym regularly are Bill, Carl and Dalia[1]. Their average age is 77, and their commitment to exercise tells us a lot about how we can improve senior health outcomes by integrating fitness into our care delivery systems.

An abundance of research demonstrates that exercise can improve the health of seniors. One study found that seniors who participated in fitness classes reported significantly better physical and emotional health and lower impairment. Another linked aerobic exercise to cognitive functioning in older adults. Our hearts, our muscles, our immune systems, and our brains: all of them benefit from exercise as we age.

Moreover, by improving health, exercise can also help shrink the cost of care for older adults by reducing the need for expensive hospitalizations. Knowing this, the question for physicians and care delivery organizations is not whether to recommend exercise for our senior patients, but how to hardwire exercise into the care we provide and ensure that our patients heed our calls to step up their physical activity.

One way health systems are encouraging exercise is by offering fitness-related benefits to their members. Just recently, the health insurer Devoted Health announced that it would offer Apple Watches as a fitness benefit. More typically, many Medicare Advantage plans offer programs like Silver&Fit and SilverSneakers, which provide seniors with a variety of benefits including low-cost gym memberships. Unfortunately, the success of these plans varies greatly and opinions about their effectiveness vary.

Nevertheless, in the world of senior fitness, there are success stories. Encore Wellness provides customized fitness programs to seniors under its Nifty after Fifty banner. The company began as a subsidiary of CareMore, the health care delivery system that I lead. Today, Encore Wellness is an independent company that serves 20,000 members not all of them CareMore patients at 30 facilities in California, Arizona, Nevada and Virginia. Its leaders say Encore/Nifty has a 20% penetration rate meaning that 20% of eligible people take advantage of its offerings.

How Encore convinced members to come in the door and keep coming back is a story that offers important lessons for those of us who care for seniors. Originally, the company made a fairly typical pitch, explaining that it could help them lower their blood pressure, shed pounds and stave off diabetes. It landed with a thud, says Michael Merino, Encore Wellness / Nifty After Fifty president and CEO.

Merino says the company decided to poll regular customers to find out what kept them coming back. Most said they enjoyed seeing their friends and meeting the staff in the fitness centers. So Encore decided to make its programs more social. It started offering group exercise classes, monthly movie matinees (with free popcorn), Wii bowling competitions, and monthly themed potluck parties. Weve transitioned from the fitness place where people also socialize to the social place where people also exercise, he says. Either way, weve found theres net more exercise going on and at the end of the day, thats our objective.

Moreover, in an age when an astonishing 43% of older adults report feelings of loneliness, which studies show can have the same effect on early mortality as smoking up to 15 cigarettes a day, Merino says Encores social programs are valuable in their own right as an effective way to alleviate the loneliness that adversely affects the health status of seniors.

But if friends and flicks get people in the door, its much more than that that keeps them coming back. In a traditional gym, seniors often face an intimidating barrage of loud music, toned bodies in Yoga pants, inattentive trainers, and unfamiliar equipment. At Encore Wellness centers, the machines are easy to use and customized for the needs of seniors.After members are personally evaluated, theyre given an electronic key-card. When inserted into the machines, a display tells the member how many reps to do and at what resistance level.

In addition, each member receives one-on-one attention from specially trained wellness coaches who remain in contact with the members physician to discuss their needs and individual progress. If a member doesnt show up for a scheduled workout, they get a friendly phone call reminding them to show up. Each workout is computer monitored and personally supervised and constantly evaluated, says Sheldon Zinberg, a physician who founded both CareMore and Encore Wellness. And thats what makes the difference.

To see that difference in action, one need look no further than Carl, who is 80 and has been diagnosed with Chronic Obstructive Pulmonary Disease. After he was hospitalized for his illness and then admitted to a skilled nursing facility, Carls wife Dalia convinced him to come to the gym. As he spins the wheels on one of Encore Wellnesss custom exercise bikes, he explains that, when he got out of the nursing facility, he couldnt walk. Now Im getting around, he says proudly. Dalia is quick to add that hes gotten strong enough to carry his own oxygen cylinder around.

Next to Carl, Bill, 78, works out his knees on another machine. Bill started coming to the gym for physical therapy after knee replacement surgery. Now he comes three times a week. When you get older, if you dont use it, you lose it, he says.

Encore Wellness notes that its efforts to help people like Carl, Dalia, and Bill stay healthy results in significant cost savings. Falls are the most common cause of nonfatal, trauma-related hospital admissions among older adults. Nationally, they result in more than 800,000 hospitalizations each year, which cost more than $50 billion to treat a number thats expected to rise to $67.7 billion by 2020.

But Encore Wellness notes that Nifty after Fifty members experience 89% fewer falls and 80% fewer fractures than non-members which the company says saves the health system between $724 and $1,929 per member per year, largely due to reduced hospitalizations.

Many health care providers say exercise is a drug, and that we should integrate it into patient care like we do other medications. I appreciate the sentiment, but I beg to differ. Unlike many medications, when done appropriately and under a physicians supervision, exercise has almost no negative side effects. And unlike expensive new drugs, as Encore Wellnesss model shows, exercise can reduce costs in the health care system. For these reasons, its time for physicians, nurses, and health care organizations systems to make their own new years resolution to prioritize exercise as an intervention they prescribe to their patients.

See the original post here:
When Exercise Is The Best Medicine - Forbes

The first time I met Joe was in an empty chapel in Palo Alto, Calif. Id come there because one of his students, a friend of mine, told me he was a medical mystery. A 77-year-old Parkinsons patient whod had the disease for at least 11 years but, with only a small dose of medication (carbidopa-levidopa), was able to drastically improve his motor skills and quality of life beyond what even his physicians could believe. He was now teaching Qigong and Tai Chi in the community on Wednesday afternoons in a spacious, wooden room in a church on Cowper Street.

The chapel had no pews, only a single carpet in the center. Joe, the only other person in the room, stood on the border between concrete and carpet, with a walker. Today, no other students showed up; it would just be Joe and me. Joe had been diagnosed with Parkinsons disease (or as his neurologist Helen Bront-Stewart calls it, PD), a neurodegenerative disorder that correlates with depletion of dopaminergic neurons in the central nervous system, resulting in slow movement, rigidity, tremors and postural instability.

He is among nearly one million Americans who will be diagnosed with Parkinsons by 2020. Parkinsons affects both motor skills, leaving patients shuffling when they walk, and cognitive skills. Unlike the other 4050 percent of people with PD, Joe is not suffering from clinically significant depressive disturbances. His fine motor skills have not deteriorated to the point of a severe loss of independence and control of his own body, leading to a loss of dignity, a progression that can be daunting for many.

Joe was first diagnosed with Parkinsons 11 years ago, in 2008, because one of his Qigong teachers suggested that he should see a neurologist. He had fallen flat on his face several times. He had trouble dialing the phone, and he knew it. When he visited a neurologists office, the first physician said, I am happy to tell you that you have an incurable disease! The physician presumably meant to say, I am happy to tell you we have a diagnosis. Unfortunately, its an uncurable disease, but the words had come out too quickly. Joe, of course, was shocked. The physician never apologized for the impact of his language, but his language prevented Joe from further medical inquiry for some months.

Joe put himself under the care of another physician, one who remains his current neurologist. Bront-Stewart, PD specialist and renowned Stanford researcher on movement disorders, came into the profession from her experience as a former ballet dancer interested in how bodies can understand what we ask of them. She placed him on medication to manage his progressive symptoms like tremors and falls. The medicine, levodopa and carbidopa, replaces the dopamine no longer provided by the dopaminergic neurons. But after half a year of monitoring Joe, she realized something about him was different. Joe remembers her saying to him, Of all of the people I know who have Parkinsons, you handle it better than anyone else I know, besides only one other persona 30-year yoga practitioner.

I had come to see in what ways Joe was different. Joe welcomed me to his class. I walked onto the carpet, shoes off. Joe turned towards the wall to park his walker, knees rolling slightly in and out in a tremor, and his hands quivered as he set the walker down.

We began the Qigong lesson by moving into the first standing pose. Qigong, a moving meditation originally from China, integrates body posture, movement and meditation. It might work to help Joe with his symptoms because his focused attention on his body allows him to still the body. Eastern medicine calls it Qi or Chi (life force); Western medicines full understanding of its biological mechanism is still unclear.

I began to mirror Joes stance, knees slightly bent, spine tucked under. The deeper we got into the standing posture, the more I noticed Joes tremors subside. Within only a few minutes, the tremors had completely dissipated. His entire body opened and closed with his breath, and his movements calmed. I was in awe at the transformation.

I asked Bront-Stewart what the possible mechanism could be for Joes transformation. She remembers 20 years ago, when I first prescribed exercise, my colleagues thought I was nuts. They teased her that she was prescribing yoga all day long. But in 2006 the American Academy of Neurology changed their guidelines based on evidence, recognizing exercise as neuroprotective.

These days, exercise, according to Bront-Stewart, is the buzz word. Exercise has been shown in over 20 studies in both mouse and human models to reduce neurodegeneration and neuroinflammation while increasing the growth and connections of new neurons. Particularly for neurodegenerative disorders like Parkinsons, exercise can help reverse the disease process, Joe being a vivid example of how powerful exercise and movement practices can be.

For her patients, Bront-Stewart doesnt care what type of exercise they do, as long as they enjoy it and feel in touch with their bodies. She prescribes yoga, Tai Chi, tango, boxing, cycling and many other forms of exercise. She says that the most important question for patients is how do you feel your own body? She sends many of her patients to a Rock Steady boxing class where she said, they feel like they can finally do something, and their sense of self is much better.

Even with Tai Chi, patients, she said, get a sense of having a beautiful way of moving again. Especially in light of a shifting body image, this was a powerful feeling for Joe, the feeling of connectedness with his own body, its movement in space, and the flow of life force within his body.

Randomized control trials show that tapping into the mind-body connection via physical exercise rehabilitation programs drastically improve quality of life and motor outcomes for patients with Parkinson's, even leading to Harvard Medical School opening up a 12-week Tai Chi program for Parkinson's. In 2016, Bront-Stewart worked with the architect of the Stanford neurosciences building to include a dance studio for PD patients, now one of the most lively spaces that not only encourage movement but provides a sense of community. Meanwhile, Dance for PD under Mark Morrisons Dance Group, has opened classes in over 25 countries in the world.

While exercise has been shown to help the motor aspects of Parkinsons, some of the next questions for Parkinsons involve the nonmotor symptoms. This is what Joe cares about. Neurologist Kathleen Poston, Stanford researcher on the cognitive and memory problems in people with Parkinsons, recognizes that beyond the physical impairment, much of the emotional stress on a person comes from increasing cognitive difficulties and dementia.

According to Poston, exercise may also contribute to slowing the progression of nonmotor symptoms, though studies have only included nonmotor symptoms as secondary outcomes, those [results] of which are still questionable. Her research focuses on the nonmotor symptoms as the primary outcomes. While we know that the mind-body connection is important, the full pathophysiological understanding of PD is still unclear: We need to push.

For Joe, Qigong and Tai Chi have served a profound role in his life for managing both motor and cognitive aspects of PD. When he is not teaching classes or handling the details of his life, he spends his time reading up on the literature, as noted by his stack of neuroscience, sleep medicine, and Chinese medicine books on top of the chapel piano. I asked Joe, What can you teach doctors about how to best care for patients when theres not always a cure? He replied with confidence, We change what we believe depending on the evidence. If we could all soften our belief systems and be humble about what we believe because in the end, healing is a one-to-one project.

Read more:
Reclaiming Control in the Face of Parkinson's - Scientific American

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From shedding weight to paying off debt, New Years resolutions are among the worlds most time-honored traditions. Just as traditional is the habit of breaking of them.

Countless studies have been done on resolutions, and the bottom line is that while most people make them, very few keep them for more than few months, if not weeks.

At the core of most resolutions is a desired change of thought or practice that will lead to positive outcome in ones life, said Tonya Hansel, director of the doctorate program at the Tulane University School of Social Work.

However, for many, when we think of New Years resolutions, failure comes to mind. Changing ones behavior is never easy and the key to success is small steps.

She said her best advice is to select one resolution for the New Year and use the following tips to achieve it in 2020.

Hansel, who holds both masters and doctorate degrees in social work, is available for interviews and can be reached at Tcross1@tulane.edu or by contacting Barri Bronston at bbronst@tulane.edu or 504-314-7444.

See the rest here:
New Years resolutions: how to make them and make them stick - Newswise

(Editors' Note: This sponsored article is part of Club Industry's report, " Cardio and Strength Equipment Trends, Technology, Purchasing and Maintenance." To download this free report, click here.)

The dynamics of the fitness industry make it hard to keep up withalltraining trendscurrentlyin demand.From fitnesstechnologyto workouts on-demandandCrossFit tohigh-intensity interval training (HIIT) all are popular,but what doclientsreally want?Toprovidesomeinsight,we reviewed threefitness trends reportsthat collecteddatafromfitness professionals, studios and fitnessenthusiasts.

The American College of Sports Medicine(ACSM)began surveying the top fitness trendsabout13years ago and launcheditsfirstWorldwide Survey of Fitness Trends Reportin thefall of 2006.Since then,it has become one of the most referenced reportson the topic for the industry.To get asenseof theindustrysstrongest trends,weexaminedthe top10trends on this listover the life of the survey.

If you throw out the top two trends on the surveypersonal training and employing educated, experienced fitness professionalsas seeming to be a little biased coming from a panel of fitness professionals,thetrendwith the most staying powerisstrengthtraining. It has beenin the top10for12of the past13years.

The 2020 edition,however,changedstrengthtrainingtotraining withfreeweights.Why? The termstrengthtrainingis a broad term. Instead, ACSM uses training withfreeweights,which is defined asexercises featuringbarbells, kettlebells, dumbbells and medicine balls. Body weight training has also been listed in the top training trends for the past seven years andalsocould becategorizedasa type ofstrengthtraining.Based on this information,the shiftwithin thebroadstrength training trend (at least for now)is focused onmore traditionaltraining tools and methods,such as free weights and body weight exercises,as opposed to usingselectorizedstrength machines.

Sowhat are themost popular forms ofcardiotraining?If HIIT wasfirst to pop into your mind, youare correct.Again, looking over the history of the ACSMFitness TrendsReport,the first timethe ACSM mentions atraining type thatwould be categorized ascardiovascular-basediswhen is mentionsHIIT, which appearedin the topspotin 2014. Ithas been in the top three ever since.The benefits ofHIIThave beenresearched and validated over the years. Fromtheafterburn effectmade possible byEPOCto themost effective workout to do in a time crunch, HIITis still on top and making an appearance in many programs:Tabata drills, sprints,timed max intervals all aimed atthe goal of producing all-out effort in a short time frame.

Another survey on cardio comes from MINDBODY.People whoworkout in a group exercise environmentprefer to get their cardio and/or HIITina danceorcyclingclass, according toMINDBODYs 2019 survey,Fitness in America: Behaviors, Attitudes, and Trends. Thereportshares thatcardio machinesarepopularcardiovascularmodalities for group exercisers,confirmingthatgroup classesthatimplementcircuit-styletrainingwith bodyweight or free weight strength exercisespaired with HIIT intervalsoncardio machineshavepaved theway fortreadmills, bikes and rowing ergometersto enter the group training space.

The third report examinedpopulartraining typesfor fitness enthusiastsby region.Strengthtrainingis the most popular activity by cityacrosstwo-thirdsorapproximately67percentof the United States, according to a study byClassPassof people who use the companys services.Unfortunately, strength training was never specifically defined,butif you cross-reference with ACSMs most recent trends report,you might assume thatthese classes likelyusefree weights, kettlebellsandbarbellsas their strength-training tools of choice.It did not appear thatclassesdefinedascardio-basedwere as popular forthose usingClassPass. Yoga was thenext most popularwithcycling cominginadistant third.

Speaking of surveys, if you still arent sure what equipment or program to invest innext,conducting a member surveymight be a good nextmove.Members like to be heard and acknowledged, and offering them aquestionnairespecific to yourtraining spacemightprovide thefinaldirection you needto choose whats next for yourfacility.

BIO

Elisabeth Fouts serves as the education coordinator forPower Systemsand is their primary content contributor for blogs and articles on a variety of subjects from personal training and group fitness programming to product spotlights and health club operations. She holds a B.S. in exercise science and has more than 12 years of experience in the fitness industry as a personal trainer and group fitness instructor as well as regional level fitness management. Fouts is also a master trainer forPowerWaveMaster and holds industry group fitness certifications with ACE and Les Mills.

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Top Cardio and Strength Training Trends from Fit Pros to Average Joes - Club Industry

Updated: May 25, 2018:

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2019 End of Year Plan Sponsor To Do List (Part 4) - Executive Compensation - JD Supra

NASHVILLE, Tenn., Dec. 16, 2019 /PRNewswire/ --Tivity Health, Inc. (Nasdaq: TVTY), a leading provider of nutrition, fitness and social engagement solutions, announces the launch of its Scientific Advisory Board (SAB). The role of the Tivity Health SAB is to review and advise on product strategy and new product concepts to provide an objective, external perspective in the context of proven evidence, emerging research, and trends in nutrition, exercise and social sciences.

The Tivity Health SAB is comprised of eight experts in the fields of nutrition, obesity and weight loss, fitness and exercise, aging, social health, and precision medicine. Its members include former Nutrisystem SAB members Arthur Agatston, M.D.; Caroline Apovian, M.D., FACN, FACP, FTOS; Ted Kyle, RPh, MBA; and Jay Satz, Ph.D. who are joined by new board members Evan Forman, Ph.D.; Sandro Galea, M.D., MPH, DrPH; Chris Mason, Ph.D.; and Christine Rosenbloom, Ph.D., RDN, FAND.

"We are excited to announce the new Tivity Health Scientific Advisory Board, and we are grateful for their commitment to the Tivity Health mission," said Donato Tramuto, Chief Executive Officer, Tivity Health. "These distinguished professionals help us evolve our products and ensure that we are delivering highly impactful solutions to improve the health and vitality of our members and customers."

Tivity Health is actively addressing the social determinants of health, (SDOH) defined by the World Health Organization as the conditions in which people are born, grow, live, work and age. With its family of healthy life-changing solutions, Tivity Health's goal is to transform the aging experience and reduce factors that lead to serious health issues and high medical costs; including chronic conditions, obesity, inactivity, social isolation, and loneliness.

The Tivity Health SAB will ensure product strategies and solutions to impact SDOH are supported by scientific evidence. They will also advise the company's research strategy and approaches to test and optimize product effectiveness and value.

The former Nutrisystem SAB was instrumental in the success of programs and products such as Turbo10, Lean13, Turbo13, and DNA Body Blueprint, as well as the development of the South Beach Diet program.

The new Tivity Health SAB has the expertise to ensure a strong scientific foundation for effective, differentiated products for healthy living and aging across all Tivity Health brands including SilverSneakers, Nutrisystem, South Beach Diet, and the recently announced Wisely Well, a new meal delivery program that will offer fully prepared meals to meet the dietary needs of older adults.

For more information on Tivity Health's SAB and its members, please visit http://www.tivityhealth.com/scientific-advisory-board.

About Tivity Health, Inc.

Tivity Health (Nasdaq: TVTY) is a leading provider of healthy life-changing solutions, including SilverSneakers, Nutrisystem, Prime Fitness, Wisely Well, South Beach Diet and WholeHealth Living. We are actively addressing the social determinants of health, defined as the conditions in which we work, live and play. From improving health outcomes to reversing the narrative on inactivity, food insecurity, social isolation and loneliness, we are making a difference and are transforming the way we do health. We are also proud to host an annual Connectivity Summit that brings together stakeholders from all over the United States to discuss and create opportunities for older adults to live their best healthy lives. Learn more at TivityHealth.com

View original content to download multimedia:http://www.prnewswire.com/news-releases/tivity-health-announces-formation-of-new-scientific-advisory-board-300975337.html

SOURCE Tivity Health, Inc.

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Tivity Health Announces Formation of New Scientific Advisory Board - BioSpace

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