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This year, WayForward is celebrating their 30th anniversary with the release of the latest entry in their flagship Shantae series titled Shantae and the Seven Sirens. I quickly fell in love with the Shantae series after playing Pirates Curse and Half-Genie Hero on my Nintendo Switch, and I couldnt wait for the chance to play the next offering in the series. I recently completed Seven Sirens and wanted to share my thoughts on the game and how it compares to the previous titles. This review will focus on the Nintendo Switch version, and the experience may vary on other platforms.

The protagonist is a half-genie, half-human named Shantae. This game opens with Shantae and her friends on a vacation getaway to Paradise Island. Shantae was invited to partake in the islands Half-Genie Festival with other Half-Genies like herself. But when the festivities got underway, the lights went dark, and when they came back to, she was left alone on the stage. Its up to Shantae to find her missing Half-Genie friends.

She runs into her old nemesis, Risky Boots, and immediately suspects that she is behind the disappearances. Risky is certainly up to no good, but theres more to it than meets the eye. Theres a legend about creatures known as Sirens that live deep beneath the island and have been terrorizing the land for a long time. Shantae has to fight these Sirens and rescue the Half-Genies. It all leads up to the final battle to determine the fate of Paradise Island. There were some twists and turns, but its more fun if you play the game to find out.

No time for vacationing after Harmony and her friends mysteriously vanished at the Half-Genie Festival.

With Seven Sirens comes the return of the familiar Metroidvania style the series is famous for, after Half-Genie Heros departure of it in favor of a more linear experience. Its very much like Pirates Curse in that youll need to revisit different zones once youve properly equipped yourself with the powers necessary to advance in the map or acquire items. The mode of travel is different this time around. In Shantae and the Pirates Curse, you needed to go to Riskys ship to sail to different locations. In Shantae: Half-Genie Hero, you needed to visit Sky and ride on her bird Wrench to your desired location. In this game, you use warp rooms, which have platforms you jump on that teleport you to specific spots. As you advance through the map, youll unlock more warp rooms above and below Paradise Island. There is no Scuttle Town in this game, but there are three towns instead, including Arena Town, Tree Town, and Armor Town.

I like the controls overall and the new ways that magic was implemented into the game. Most of the basic controls still apply. You can whip your hair at enemies (while upgrading them to be faster and more damaging) or you can cycle through an assortment of magic weapons such as fireballs, pike balls, rockets, and scimitars. You can buy these power-ups in shops using the in-game gem currency. But there are new ways in which transformations are implemented. Shantae and the Seven Sirensintroduces Fusion Magic, which are powers you inherit from your half-genie comrades. There are two kinds of this magic: Fusion Forms, which allow you to transform with a dedicated button, and Fusion Dances, where you can dance to activate a special power. For example, you can Fusion Form into a Newt, which allows you to zip through the air and climb walls. There is also the Seer Dance, which when performed will make hidden objects appear on the screen.

There are up to nine different ways to transform, including the Quake Dance.

It may sound complex, but I enjoyed how much quicker its made the gameplay experience. If I need to drill through the dirt I dont need to dance; as long as I acquired the Drill Coin, I just need to move in the direction I want to drill and Shantae will instantly transform as needed. Speaking of power-ups, another new addition comes in the form of monster cards. These are cards that appear at random as you defeat different enemies in the game. They all have different perks, such as boosts in the attack, defense, speed, magic meters, etc. There are rare cards in the game that can only be acquired through villagers by trading in nuggets, which can be found hidden throughout the map.

My only gripe here is some of these rare cards are practically worthless relative to when they can be acquired in the story. There are also heart squids you can find and trade to the Squidsmith for extra heart holders (basically extends your life meter; think of heart containers from Legend of Zelda), as well as hidden statues and treasure chests. Your magic is the key to unlocking the secrets of Paradise Island.

Collect gems and spend them at the town shops to add magic weapons to your arsenal.

In terms of difficulty, the game isnt that hard once you get the hang of the controls and figure out how to stock up on items. Its still challenging and can be even more so if youre a completionist who doesnt believe in using guides (there are some hidden items that I dont know how I would have found if not for guides and YouTube videos). I appreciate that WayForward showed some mercy and didnt have a stupidly difficult timing jump thing with spikes like it did in the final levels of the previous two games. Seriously. I needed to exploit a glitch just to get up that tower in Pirates Curse. It was ridiculous, but thats on me.

Boss battles in Seven Sirens felt fairly simple to me, similar to past Shantae games. The key is to always take advantage of the powers you had most recently acquired. Its sort of like Mega Man in a sense. I want to add that the final boss battle felt the most epic of all the Shantae games that Ive played, at least from a visual standpoint. For me thats saying something, considering I got chills while battling Tinkerbrain in HGH.

Gorgeous animated cutscenes appear as you face new obstacles such as the Sirens.

Also want to mention that there is a New Game Plus mode, where you play as Shantae in her hula costume, and get a higher magic meter but less defense. Im still in the middle of playing it and its noticeably more challenging. My experience is that the increased magic meter does not offset the amount of damage I can get, so I consider the margin for error to be smaller. Its given me an excuse to play the game all over again with a higher level of difficulty. Bring it on!

Half-Genie Hero had a couple of DLC packs that allowed you to play effectively new modes as other characters, such as Sky, Bolo, Rottytops, and even Risky Boots. I enjoyed those modes and it was a little disappointing that those characters are non-playable in this game. The awesome, anime-inspired intro (which Ill get into in a second) seemed to tease the possibility of playing as those characters but that simply wasnt the case. Its something I hope that will be considered for the sixth installment of Shantae in the future.

When I was at PAX East earlier this year, I was able to play a demo of the game in what I now recognize is the Water Lily stage. What stood out to me then was that the game played similarly to Pirates Curse but the sprites still resembled Half-Genie Hero. Now that Ive had a chance to play the game in full, Ive been able to greater appreciate its visual aspects. Yes, they recycled some assets from HGH, but I prefer it to the pixelated look from Pirates Curse. I kind of liked the 3D-ish look of the levels in HGH so I missed seeing that here in Seven Sirens, but I dont mind sacrificing that for the sake of getting it back to its Metroidvania roots.

Solve puzzles and make new discoveries as you travel through the depths of the sunken city.

Ive always enjoyed the banter when Shantae speaks with other characters. There didnt seem to be as much of it in HGH (I need to emphasize that the previous game was a big departure from what the Shantae series was known for, which is why I keep bringing it up). Im glad the dialogue ramped back up with this one. Squid Baron is such a delightful dork, what a treat he is.

I was quite satisfied with how the game looked. Its a platformer so nothing too fancy needed, though I did appreciate the hand-drawn art of the background in those deep-water levels. The GUI was sleek and easy to navigate. Seven Sirens continues the Shantae tradition of cute and sexy character designs the series has always been known for. Im not exactly sure why this games ESRB rating went down from Teen to Everyone 10+, because as far as fantasy violence and suggestive themes are concerned, I saw no difference.

Youll need your Fusion Magic to defeat the lovely but deadly Water Lily Siren.

Another thing I loved was the addition of animated cutscenes.Beautiful stuff. Im a big fan of the cutscenes and hope we see more of them in the future. That includes the games introduction video, which was animated by Studio Trigger. What a tease! A Shantae animated series is something I didnt know I needed in my life.

(While were on that topic, hey Matt Bozon and WayForward! Cant you guys work something out with Netflix? Just need Cristina Vee on board and were Ret-2-Go! Make it happen! Okay let me get back on track)

Everyone waiting patiently for Shantae to be playable in Smash (j/k). The gangs all here on another adventure.

Let me get sound effects out of the way here. Nothing significant to report, its the same as usual. This game had a whopping nine different voice actors, more than double the previous game. I adore Vees work as Shantae (she voices two other characters in the game as well). Its the little details that I get a kick out of, like the sound of satisfaction when Shantae eats or drinks something, or when she yells out the name of her power. Too cute! Please never change.

What was significant, perhaps more than anything was the change with its soundtrack. There was a changing of the guard when long-time WayForward music composer Jake Kaufman announced that he left the company back in 2014. He had composed every Shantae game up to that point, and HGH was his final project in the series. Music is an art form that has the ability to move you through sound, and Kaufman was masterful at it with his video game soundtracks. The musical experience throughout Pirates Curse and Half-Genie Hero was remarkable, and the first thing I remembered about playing those games more than anything else. The File Select theme for Pirates Curse had no business being the absolute banger that it was. So imagine my disappointment when I discovered that this new installment to the Shantae series would no longer feature its super talented, long time composer.

You can use up to three monster cards at a time to enhance your abilities.

Kaufman set the bar high, so I had to set my expectations low and keep my mind open. Still, I was afraid, but I have to say WayForward somehow knocked it out of the park yet again. The soundtrack is made by a group headlined by Japanese composer and chiptune enthusiast Professor Sakamoto. I enjoyed its very distinctly 8-bit theme to the soundtrack (with the Beach Travel Easttrack being one of the more robust examples of this). Yet the music at times still managed to invoke those Arabian tones that have long been synonymous with Shantae soundtracks.

Ive read other peoples reactions to the game music and its definitely polarizing. Some consider it flat and bland; others love it. Im of the mind that, yes, this is very much not Jake Kaufmans work, but these tracks are still rock solid. They set the tone just right for every location in the game.The Seven Sirens soundtrack is available on Spotify and Apple Music. I have a Spotify subscription and there are a handful of tracks from the game that I go back to for a pick-me-up. I love it.

The new composition team proves to be worthy successors and Im so glad that such a vital component to the spirit of Shantae wasnt compromised. Thank you WayForward for not letting me down there.

If you like action, comedy, puzzles, and a healthy dose of fan service, Shantaes got you covered.

This game can be enjoyed by anyone, and prior knowledge of the series isnt required, but it helps to appreciate the context behind some of the character interactions. The game is fun on its own, but the backstory adds to it. I learned that from the first time I played a Shantae game and had the jokes go over my head. Shantae and the Pirates Curse was my introduction to the Shantae series. It was an experience that utterly wowed me and one that cant be duplicated because it was the first. That having been said, Seven Sirens incorporated many of the things that drew me into the franchise while introducing fresh new concepts that kept the game from feeling stale. It had just about everything that I could want from it: endearing characters and humor; great music and eye candy; a story with plot twists; lots of action and a large map to explore; familiar comforts with new delights.

If I had to nitpick, Id say that Seven Sirens didnt strike me as quite as challenging as it could have been.Shantae herself is pretty badass once youve gotten all the powers and loaded up on potions and monster cards. I would have liked for the map to have been just a little bit bigger and the game a little bit longer to beat. Its partially why I felt compelled to play it over with New Game Plus mode.

Shantae is the main hero but it would have been awesome if there was a chance to switch between characters, similar to the Friends to the End DLC in Half-Genie Hero. The Half-Genies give their powers to Shantae throughout the game but it would have been neat to be able to control them instead. Maybe alternate similar to Friends to the End, or going further back, the Teenage Mutant Ninja Turtles game for NES where you could pause and switch turtles. As the player I wouldve felt more drawn in to these newer characters. Theres so much potential with this series and the game left me wanting more, for better or worse. Thats about all I can think of in terms of room for improvement.

It was an absolute joy to play this game from start to finish. Shantae games deliver on the fun every time. I gravitate to video games that make me smile and laugh as I play, and this one did its job.I wanted more Shantae in my life, and after waiting patiently for the games release, WayForward finally granted my wish with Shantae and the Seven Sirens.

If youre ready to dance through the danger, you can pick up Shantae and the Seven Sirens today for Nintendo Switch, PlayStation 4, Xbox One, Steam, or Apple Arcade. Please leave a comment below and let me know what you think about this game. Thanks for reading and happy gaming!

Gain a new transformation when you get a Fusion Coin from your rescued ally.

Do battle with the Queen of the Seven Seas.

You can quickly travel across the map using warp rooms.

Belly dances unlock special powers.

This review was written based on a digital review copy of Shantae and the Seven Sirens for the Nintendo Switch provided by WayForward.

View post:
Shantae and the Seven Sirens Nintendo Switch Review - A Wish Granted - The Koalition

In this report, the Global Infrared Search and Track (IRST) system market is valued at USD XX million in 2019 and is expected to reach USD XX million by the end of 2026, growing at a CAGR of XX% between 2019 and 2026. Global Infrared Search and Track (IRST) system market has been broken down by major regions, with complete market estimates on the basis of products/applications on a regional basis.

Browse full research report at https://www.crystalmarketreport.com/global-infrared-search-and-track-irst-system-market-insights-and-forecast-to-2026

Market Analysis and Insights: Global Infrared Search and Track (IRST) system Market

The global Infrared Search and Track (IRST) system market size is projected to reach US$ XX million by 2026, from US$ XX million in 2020, at a CAGR of XX%% during 2021-2026.

Global Infrared Search and Track (IRST) system Scope and Segment

Infrared Search and Track (IRST) system market is segmented by Type, and by Application. Players, stakeholders, and other participants in the global Infrared Search and Track (IRST) system market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on production capacity, revenue and forecast by Type and by Application for the period 2015-2026.

The following manufacturers are covered in this report:

Aselsan

HGH Systmes Infrarouges

Leonardo

Lockheed Martin Corporation

Northrop Grumman Corporation

Rheinmetall

Safran

Thales Group

Tonbo Imaging Private Limited

Infrared Search and Track (IRST) system Breakdown Data by Type

Civil Grade

Military Grade

Infrared Search and Track (IRST) system Breakdown Data by Application

Airborne

Naval

Land

Others

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The Infrared Search and Track (IRST) system market is analysed and market size information is provided by regions (countries).

The key regions covered in the Infrared Search and Track (IRST) system market report are North America, Europe, China and Japan. It also covers key regions (countries), viz, the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.

The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of production capacity, price and revenue for the period 2015-2026.

Competitive Landscape and Infrared Search and Track (IRST) system Market Share Analysis

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Global Infrared Search and Track (IRST) system Market Insights and Forecast to 2026 - Jewish Life News

Three days after failing a drug test and having his July 9 fight against Jerry Forrest canceled, Jarrell "Big Baby" Miller made his first public comments about the failure, pushing back against the allegations.

"I have never, ever willingly taken a steroid for performance-enhancing purposes," Miller told Fight Network. "Did I take something for healing properties, for injuries? Yes, I have. But to win a fight and during a training camp? No, I have never done that.

"Nobody can be more outraged than me," he said of the allegations. "I'm the one that's lost millions of dollars. I'm the one that's had his career on the line. ... But I have to think about it with a straight mind. I have to figure it out. Sit down with my team. Get everything in order and get everything done in the right way."

Miller stated repeatedly that his team is going through a legal process and that, ultimately, the facts surrounding this situation will be released. He believes he listed the contaminated substance on a form that is submitted to the Voluntary Anti-Doping Association as part of the testing process.

2 Related

The most recent drug test failure is another in a growing line of infractions for Miller. Last year, Miller (23-0-1, 20 KOs) was scheduled to face unified heavyweight titleholder Anthony Joshua at Madison Square Garden in New York, but he lost that opportunity as he tested positive for the banned substance GW1516 with a urine test conducted by the VADA in March 2019. Further tests revealed HGH and IPO. In total, Miller failed three drug tests prior to his scheduled bout with Joshua.

At the time, Miller's request for a boxing license was denied by the New York State Athletic Commission, and he was eventually given a six-month suspension by the WBA. Miller has not fought since. The last time Miller performed in the ring was in November 2018, when he stopped Bogdan Dinu in four rounds.

Miller was also suspended for nine months in 2014 for methylhexaneamine, during his days as a kickboxer.

In January, Miller agreed to a co-promotional deal to fight under the Top Rank banner, and the July 9 fight was to be his debut for the promotion. As he reflected on the current situation, Miller apologized to those who had given him another chance.

"I've done my research and homework to do my best to not make this happen, and all I can do is apologize to Bob Arum, apologize to Jay [Prince]," he said. "But at the same time, I did do my homework. I did put my best foot forward. I did let VADA know of certain circumstances. I did my part as a human being and as a fighter ..."

While the details are sorted out and Miller is now temporarily suspended by the Nevada State Athletic Commission, some have called for the permanent revocation of Miller's boxing license. Miller was adamant that a permanent suspension would be excessive in this case.

"I should not be banned [for life]," he said. "I'm prepared to accept my suspension and be willing to do my monthly testing [during] my suspension, but to be banned for life? You're out of your mind.

"It's sad. I'm angry about it, but like I said, there is an explanation for it, and me and my legal team are working on it."

ESPN's Steve Kim contributed to this report.

Excerpt from:
Jarrell Miller says he has never willingly taken a steroid to enhance performance - ESPN

Alexion Pharma Receives European Approval for Ultomiris

Alexion Pharmaceuticals (ALXN) announced that its lead drug candidate Ultomiris has been approved by the European Commission. Ultomiris may now be used for treating adults and children with atypical hemolytic uremic syndrome in Europe. The drug candidate is the first and only long-acting C5 complement inhibitor that needs to be administered every eight weeks.

The European Commission based its data on two global, single arm studies of the drug candidate. One of these studies was conducted in adults while the other was conducted in children. Both the trials are still operational. The interim analysis involved 56 out of 58 complement inhibitor treatment-nave adults and 18 out of 21 complement inhibitor treatment-nave children. For the initial 26-week treatment periods, 54 percent of adults and 77.8 percent (interim data) of children showed Complete TMA Response.

In the 52-week follow-up period, 4 more adult patients and 3 pediatric patients demonstrated a Complete TMA Response that was validated after the 26-week Initial Evaluation Period. This additional data takes the overall Complete TMA Response of 61 percent in adults and 94 percent in children as shown in interim data.

The drug is expected to create a niche for itself in the market with its convenient dosage regimen of eight weeks. John Orloff, M.D., of Alexion said, Treatment with ULTOMIRIS offers convenient eight-week dosing, which we believe is preferred by patients because it provides them with greater flexibility and improved quality of life, while also reducing the burden on healthcare systems that currently face significant strain in many countries. Atypical HUS is an ultra-rare disease which impacts vital organs such as kidneys by damaging walls of blood vessels.

The company has established a Risk Management Plan for ULTOMIRIS for minimizing the risk of side effects for patients. The most frequently observed adverse reactions related to the drug were nausea, upper respiratory tract infection and headache, among others. ULTOMIRIS is known to cause meningococcal infections, however, aHUS studies did not report any such incident.

ULTOMIRIS was approved by the FDA in 2019 for treating aHUS in adult and pediatric patients of one month of age and older. The drug is also approved in the United States and Japan for treating adult patients suffering from paroxysmal nocturnal hemoglobinuria. In Europe, the drug is authorized for treating patients with PNH with hemolysis with clinical symptoms indicative of high disease activity. The companys application for marketing authorization as a treatment for aHUS is currently under review in Japan.

ULTOMIRIS works by controlling the C5 protein in the terminal complement cascade. The treatment is designed to be administered intravenously every eight weeks or every four weeks for pediatric patients less than 20 kg, following a loading dose.

Alexion is a biopharmaceutical firm and focuses on complement biology and inhibition. The company has two approved complement inhibitors and two enzyme replacement therapies in its portfolio. It also has robust development pipeline with a number of prospective therapies in advanced trial stages. The company seeks to work on developing novel molecules and their impact on core therapeutic areas such neurology and nephrology.

Intercept Pharmaceuticals Inc. (ICPT) reported that it has received a Complete Response Letter from the FDA with regard to its Fibrosis drug. The letter indicates that agency has found the predicted benefits of the drug candidate to be uncertain. The FDA has recommended the company to submit post-interim analysis efficacy and safety data. The FDA stated that it felt that the modest fibrosis effect was not clearly predictive of clinical efficacy,

Intercept had earlier indicated that it expected the review may take longer than the previously announced PDUFA goal date as the agency had postponed a tentatively planned advisory committee meeting. Mark Pruzanski, M.D.,CEO of Intercept said, At no point during the review did the FDA communicate that OCA was not approvable on an accelerated basis, and we strongly believe that the totality of data submitted to date both meet the requirements of the Agencys own guidance and clearly support the positive benefit-risk profile of OCA. The FDA has recommended the company to continue the long-term outcome phase of its trial.

The NDA submission for obeticholic acid is the first for NASH. The application was backed by the data collated from 35 clinical trials. OCA is the only investigational NASH drug to demonstrate replicable ability to overturn or stabilize liver fibrosis in patients with advanced fibrosis due to NASH. The FDA has asked Intercept to submit additional data from its ongoing REGENERATE study to support its potential accelerated approval pathway.

There is no approved therapy for treating NASH fibrosis yet. OCA has been given Breakthrough Therapy designation by the FDA. The OCA is already approved by the FDA for treating primary biliary cholangitis.

Ascendis Pharma A/S (ASND) announced that it has submitted a Biologics License Application to the FDA seeking label expansion for TransCon. The company is looking to add the treatment of pediatric growth hormone deficiency to its label. Currently, there is no approved long-acting growth hormone treatment available in the United States or Europe.

TransCon hGH is a long-acting once-weekly prodrug of somatropin and aims to work on the same mode of action as daily daily hGH therapies. The drug candidate provides the therapeutic benefits by releasing the same growth hormone molecule, somatropin. Jan Mikkelsen, CEO of Ascendis said, We believe the TransCon technology has the potential to address major unmet medical needs and we look forward to continuing the late stage clinical development of our other endocrinology rare disease product candidates, TransCon PTH and TransCon CNP, as well as filing an Investigational New Drug application for our first oncology product candidate later this year.

The company plans to file a Marketing Authorization Application for the drug candidate in Europe during the third quarter. The drug candidate has orphan designation for GHD in both the United States and Europe. Ascendis plans to begin a new Phase 3 trial with TransCon hGH in pediatric GHD in Japan. The trial will likely be initiated in the fourth quarter. Another Phase 3 trial is currently underway in Greater China. Ascendis is collaborating with VISEN Pharmaceuticals for this purpose.

TransCon denotes Transient Conjugation and is a proprietary technology platform for producing more efficient therapies. The three main components of a TransCon molecule are an unmodified parent drug, an inert carrier to protect it and a liker to temporarily bind the two.

Ascendis Pharma has strong development pipeline with three independent endocrinology rare disease product candidates. The company is now looking to expand its focus on oncological segment.

Thanks for reading. At the Total Pharma Tracker, we do more than follow biotech news. Using our IOMachine, our team of analysts work to be ahead of the curve.

That means that when the catalyst comes that will make or break a stock, weve positioned ourselves for success. And we share that positioning and all the analysis behind it with our members.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Read more:
Alexion's European Approval And Other News: The Good, Bad And Ugly Of Biopharma - Seeking Alpha

The Health and Safety Executive (HSE) says it carried out more than 1,000 spot checks in the first three weeks after it resumed inspections.

The safety watchdog restarted proactive inspections of construction and other sites in late May. Figures supplied to Construction News by the body for the three weeks between 26 May to 18 June show that the organisation carried out what it termed spot checks at 1,055 businesses across all sectors.

The organisation defines spot checks to include phone calls as well as site visits. It did not break down the figures between types of sector.

Some 107 firms who were subject to spot checks were subject to follow-ups from inspectors.

A spokesman said: HSE inspectors and local authority inspectors are visiting workplaces across a range of sectors following up reports or concerns about safety in the workplace including over COVID-19 and ensuring compliance. HSE is carrying out proactive checks to ensure that appropriate measures are in place to protect workers from COVID-19.

Putting duty holders on the spot, and checking on how they are managing risks has always been part of our regulatory approach.

The organisation has, however, suspended its release of RIDDOR statistics relating to the coronavirus, in what a spokesman said would be a temporary move while it refines its data collection processes. Up to the beginning of May, the organisation said there had been 198 RIDDOR reports of dangerous occurrences and 71 fatal-disease reports relating to COVID-19 across all industries.

One of the firms subject to an unannounced visit by inspectors was HGH Groundworks and Civil Engineering at a site where the firm is the largest subcontractor. Its head of safety, health, environment and quality Martin McCabe told Construction News that the inspector carried out a routine-style visit with added questions and checks on its processes for mitigating coronavirus.

It was an overall holistic visit where they were looking at everything. As a groundworks company they were pretty interested about the plant side of things and any issues [there could have been].

They asked about our processes, what we were doing about COVID-19 and how its managed.

The inspector found no issues on the site, McCabe said.

Last month Mike Clancy, general secretary of the Prospect union, which represents HSE inspectors, warned that the organisation would not be able to carry out spot checks with much frequency after it restarted work. The common understanding of what the HSE would do is much at odds with what it can do, due to its level of resourcing, he told CN.

See the article here:
HSE 'putting firms on the spot' over COVID-19 - Construction News

This report also covers the impact of COVID-19 on the global market. The pandemic caused by Coronavirus (COVID-19) has affected every aspect of life globally, including the business sector. This has brought along several changes in market conditions.

The Infrared Search and Track IRST Systems Market report considers the major factors accountable for driving the growth of the Infrared Search and Track IRST Systems Industry, in addition to the key hindrances and challenges. In the initial segment of the report, the market definition, market overview, product description, product scope, product characterization, and product specification has been discussed. The information presented in this report provides an overview of the latest trends and development plans, patterns, and policies observed in the global market. Moreover, the study offers an analysis of the latest events such as the technological advancements and the product launches and their consequences on the global Infrared Search and Track IRST Systems market. The global market also comprises the data accumulated from numerous primary and secondary sources.

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TheMajorPlayers Covered in this Report: Leonardo S.p.A, Thales Group, Rheinmetall AG, Lockheed Martin Corporation, Northrop Grumman Corporation, Aselsan A.S., HGH Systmes Infrarouges SAS, Safran S.A., Tonbo Imaging Private Limited, Hughes Network Systems LLC, etc. & More.

Based on the Type:Airborne PlatformNaval PlatformLand PlatformOthers

Based on the Application:Defense SectorLaw EnforcementHomeland SecurityOthers

Results of the recent scientific undertakings towards the development of new Infrared Search and Track IRST Systems products have been studied. Nevertheless, the factors affecting the leading industry players to adopt synthetic sourcing of the market products have also been studied in this statistical surveying report. The conclusions provided in this report are of great value for the leading industry players. Every organization partaking in the global production of the Infrared Search and Track IRST Systems market products have been mentioned in this report, in order to study the insights on cost-effective manufacturing methods, competitive landscape, and new avenues for applications.

Global Infrared Search and Track IRST SystemsMarket: Regional SegmentationFor further clarification, analysts have also segmented the market on the basis of geography. This type of segmentation allows the readers to understand the volatile political scenario in varying geographies and their impact on the global Infrared Search and Track IRST Systemsmarket. On the basis of geography, the global market for Infrared Search and Track IRST Systemshas been segmented into:

North America(United States, Canada, and Mexico)Europe(Germany, France, UK, Russia, and Italy)Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)South America(Brazil, Argentina, Colombia, etc.)Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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Report Methodology:

The information enclosed in this report is based upon both primary and secondary research methodologies.

Primary research methodology includes the interaction with service providers, suppliers, and industry professionals. Secondary research methodology includes a meticulous search of pertinent publications like company annual reports, financial reports, and exclusive databases.

Key questions answered in this report:1. What will the market size be in 2026 and what will the growth rate be?2. What are the key market trends?3. What is driving this market?4. What are the challenges to market growth?5. Who are the key vendors in this market space?6. What are the market opportunities and threats faced by the key vendors?7. What are the strengths and weaknesses of the key vendors?

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What is Norditropin, prefilled pen injection and what is it used for?

Therapeutic class: Somatropin and Somatropin Agonists

Norditropin HGH Injections

Norditropin HGH pens contain the human growth hormone analog somatropin, which is identical to the growth hormone naturally produced by the human body. Children need the growth hormone to promote their growth, but adults also need it for their general health.

In children, Norditropin is used to treat growth disorders:

In adults, Norditropin is used as a growth hormone replacement when its production has been reduced from childhood or stopped in adulthood due to a tumor, tumor treatment, or pituitary gland disease. If treated for HGH deficiency in your childhood, the persistence of this deficiency will be reassessed when growth is complete. If the growth hormone deficiency is confirmed, further treatment is necessary. Somatropin can also be prescribed to those experiencing wasting caused by HIV.

Read Also: HGH Benefits: What to Expect From Using Human Growth Hormone

Never use Norditropin prefilled pen injections:

Warnings and precautions

Talk to your doctor or pharmacist before using Norditropin:

Tell your doctor or pharmacist if you are using or have recently used any of the following medications:

Read Also: Anti-Aging: HGH Can Reduce Biological Age by One Year and a Half Study Shows

Products containing somatropin are not recommended for women of childbearing age who do not use contraception.

Norditropin NordiFlex has no effect on the ability to drive vehicles and operate machinery.

Always use this medicine exactly as directed by your physician. Consult your doctor or pharmacist if you are unsure.

In children, the dose depends on weight and body surface area. After childhood, the dose depends on height, weight, sex, and sensitivity to growth hormone and is adjusted until the optimal dose is reached.

When using Norditropin 5 mg/1.5 mL, prefilled pen injection solution

Inject your daily dose under the skin every evening just before bedtime.

How to use Norditropin pen?

Do not share on your Norditropin pen with other people.

If you have accidentally used more Norditropin than you needed Consult your doctor or pharmacist immediately!

If you have injected too much somatropin, talk to your doctor. Prolonged somatropin overdose may cause abnormal growth and thickening of the facial features (Acromegaly).

If you forgot to use Norditropin:

Take the next usual dose at the usual time. Do not take a double dose to make up for the lost dose.

When discontinuing Norditropin injections do not stop taking Norditropin without first consulting your doctor.

If you have further questions about the use of this medicine, ask your doctor or pharmacist for more information.

Like all medicines, this medicine may have side effects. However, these side effects do not always occur in everyone.

Adverse reactions in children and adults (frequency not known) :

If you experience any of these effects, consult a doctor as soon as possible. Stop taking Norditropin until your doctor tells you to start taking it again.

The formation of antibodies that act directly against somatropin has rarely been observed during treatment with Norditropin.

High concentrations of liver enzymes have been reported.

Leukemia and recurrent brain tumors have also been reported in patients treated with somatropin (the active ingredient of Norditropin NordiFlex), although there is no evidence that somatropin is responsible.

If you think you have any of these conditions, talk to your doctor.

Additional side effects in children:

Unusual (may affect up to 1 in 100 children):

Rare (may affect up to 1 in 1,000 children):

Rare cases of hip and knee pain and limping have been reported in children taking Norditropin. These symptoms may be related to a disorder of the femur (Legg-Calve-Perthes disease) or slippage of the tip of the femur in relation to the cartilage (epiphysiolysis of the femoral head) and may not be due to Norditropin.

Read Also: Do HGH Supplements Like Genf20 Plus, Growth Factor Plus, GenfX, Hypergh 14X, HGH X2 and Provacyl Work?

In children with Turner syndrome, clinical studies have observed some cases of increased growth of hands and feet in relation to height.

A clinical study in children with Turner syndrome showed that high doses of Norditropin may increase the risk of ear infections.

If any of these side effects affect you significantly, or if you notice any side effects not listed in this guide, you should talk to your doctor or pharmacist as the dose may be reduced.

Additional adverse reactions in adults

Very common (may affect more than 1 in 10 adults):

Unusual (may affect up to 1 in 100 adults):

If you experience any side effects, talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this article. You can also report adverse reactions directly to the FDA.

By reporting adverse reactions, it helps to provide more information on the safety of the medicine.

Read Also: Increasing Height: Can HGH Help You Grow Taller?

Keep the medicine out of sight and out of the reach of children.

Do not use this medicine after the expiry date shown on the container.

Store unused Norditropin in a refrigerator (between 2C and 8C) away from light. Do not freeze or expose to heat.

After starting to use Norditropin store the opened pen in a refrigerator (between 2C and 8C) for up to 4 weeks or store at room temperature (not above 25C) for up to 3 weeks

Do not continue to use a Norditropin pen that has been frozen or exposed to excessive temperatures.

Do not use Norditropin Pen if the growth hormone solution inside is opaque or discolored.

Always store Norditropin without a needle.

Always keep the cap of the Norditropin Pen closed when not in use.

Always use a new needle for each injection.

Do not dispose of drugs in the sewerage system or with household waste. Ask your pharmacist to dispose of medicines that you no longer use. This will help to protect the environment.

Read Also: Growing Taller as an Adult: Is It Possible?

Norditropin is presented as a clear, colorless injectable HGH solution in a pre-filled 1.5 mL multi-dose disposable pen.

Norditropin is available in three strengths:

5 mg/1.5 mL, 10 mg/1.5 mL and 15 mg/1.5 mL (3.3 mg/mL, 6.7 mg/mL and 10 mg/mL respectively).

https://www.norditropin.com/

Continued here:
Norditropin: The facts about this Prescription HGH Brand - Gilmore Health News

Gov. Kate Brown and the Oregon Health Authority approved Marion County to enter Phase 2 of its reopening roadmap, beginning June 19

Gov. Kate Brown and the Oregon Health Authority approved Marion County to enter Phase 2 reopening, beginning Friday, June 19, county officials announced June 17.

"This important milestone comes at a critical time of need as families struggle with unemployment, businesses work hard to recover, and farmers begin their harvests," said Marion County Commissioner Kevin Cameron. "We're thrilled to enter Phase 2 and get public life in Marion County moving again."

Marion County analyst Chad Ball noted that Phase 2 allows swimming pools, bowling alleys, movie theaters, and arcades to reopen. Bars and restaurants are able to expand hours of operation to stay open until midnight, and social, civic and faith-based gatherings can meet in larger groups.

Some recreational sports can resume, including training activities within college athletic programs.

But Phase 2 also retains several physical distancing and sanitation measures for businesses and other activities to help limit the spread of the coronavirus as people become more active in the community.

The announcement comes as the governor's office also outlined some stricter measures for some counties, including requiring masks to be worn at all public indoor areas, such as grocery stores.

The governor put a hiatus on counties applying for Phase 1 and Phase 2 reopening last week as the number of daily positive and presumptive COVID-19 cases were spiking. The state saw a record 278 cases reported June 16, including 119 in eastern Oregon's Union County where an outbreak was connected to a La Grande-area church.

"I instituted the statewide pause because of the rising number of cases in both rural and urban communities," Brown said. "I did this to give public health experts time to assess what factors are driving the spread of the virus and make adjustments to our reopening strategy.

"Since then, the Oregon Health Authority has continued to analyze data in the state, including the source of the growth in new cases, hospitalizations, results of contact tracing and other metrics."

Brown said after consultations with health officials and civic leaders, Marion will join Multnomah, Washington, Clackamas, Hood River, Polk and Lincoln counties as jurisdictions where masks will be required at all indoor public spaces, beginning June 24. This step is taken as Marion, Polk and Hood River counties move into Phase 2, and Multnomah County moves to Phase 1.

"All three (Phase 2) counties have implemented timely follow-up on cases in the past week," Brown said. "While Multnomah County has seen an increase in new cases recently, the county has not experienced an uptrend in new hospital admissions, and overall hospitalizations remain well within capacity."

Brown said her office will take a more regional approach with regard to reopening decisions in the future.

"I will be grouping several counties together as regional units for future reopening decisions. This will apply to the tricounty area Multnomah, Washington, and Clackamas counties will be treated as a single unit in future reopening decisions," Brown said. "And Marion and Polk counties, which each include parts of the city of Salem, will also be treated as a unit going forward.

"Both of these regions include a highly connected urban area, making it difficult to monitor the disease based solely on the contours of county jurisdictional lines."

Ball noted that Marion County's roadmap for reopening was developed in collaboration with county health experts, other local leaders and regional public health partners.

"We're proud to see that our county has successfully slowed the spread of COVID-19 to the point where we can confidently move into Phase 2," said Marion County Commission Chair Colm Willis on June 17. "Today's success is a testament to the hard work and resiliency of the people of Marion County."

County officials continue to stress that anyone who feels sick should remain at home, regardless of the reopening. Hgh-risk individuals who are over 65 years old or suffering chronic illnesses also should continue to remain home as much as possible.

"We encourage all individuals to continue to follow physical distancing guidelines. All businesses, organizations and activities that choose to reopen should follow state guidelines, many of which are available by specific sector and type of activity," Ball said, urging residents to adhere to the face-covering recommendations and rules as well.

The governor said with the metro counties in Phase 1 and mid-Willamette Valley counties transitioning to Phase 2 reopening, the coming weeks will be crucial ones in the battle to stem the spread of COVID-19.

"The next few weeks will be difficult, and we will be monitoring the data regularly. We are much better prepared than we were in early March; we have increased PPE, much more widespread testing, and many more contact tracers," Brown said.

"However, if hospitalizations spike too rapidly, if the capacity of our health care system is threatened, we will be forced to revert to stricter rules.

"Our entire ability to reopen and stay open is dependent on whether each of us follows basic health and safety protections," she added. "Stay home if you feel sick, wear a face covering, keep six feet of distance, avoid crowds, and wash your hands regularly. We truly are all in this together."

You count on us to stay informed and we depend on you to fund our efforts.Quality local journalism takes time and money. Please support us to protect the future of community journalism.

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Phase 2 reopening OK'd in Marion County; masks to be required - Pamplin Media Group

The 2019 Norwegian based company is leaving the nest and taking the world by storm.

The creators, five Medical Doctors, spearheaded by the Co.Founder and Executive Chairman Mehdi Ettehadulhagh M.D., who is also currently an award winning innovation designer. Together with Co.Founders Nayyer Ettehadulhagh and Sina Ettehadulhagh, are putting the Entrepreneur in Entrepreneurship with their minimalistically daring designs, cutting edge textile engineering and innovations, enough to make the wheel yesterdays news.

This product (HTM1) is turning heads, already winning the Invention of the Year award few months after its release during the Medical Congress of 2019, held by the UPCAM!

With their first batch of gear going from exclusive sales in Scandinavia to shipping worldwide this year (2020), this is the type of innovation we expect from the VOT brand startup. So before melting into a pool of fandom like the witch from OZ, let us recap what this HTM1 really does!

Occluding Venous Blood-flow

Apparently getting in shape is not as simple as cucumber-water and protein-bars! Starting to workout three weeks before summer isnt going to cut it.

Or is it?

The science says; when we workout, blood flows through our bodies, and the blood that is tainted with lactic acid and growth hormones actually stimulate muscle growth! When the concentration of these hormones are high, the muscles react accordingly and grow. Mostly with exercise above 80% of our max effort.

Theres a catch, normally, the amount of growth hormones (HGH) and lactic acid stimulating the muscle is reduced in concentration due to blood-flow. (Think the amount of fish in a river, diluted throughout) Thats where the HTM1 comes in.

By slightly reducing the blood-flow out of the muscle by a few percent, the lactic acid concentration builds up around the muscle, (Think putting a dam on that same river, thus increasing the concentration of fish without increasing the amount of fish.) causing a significant increase in the concentration as well as the anabolic effect on muscle cells, the bonus? you only need to lift 15-20% of your 1RM to gain the same result as your 80-100% 5RM, yeah crazy, we know!

In other words, you now CAN start working out three weeks before summer!Watch a HTM1 transformation below:

https://votwear.com/blogs/news/173-day-occlusion-training-wear-transformation

Whats next for the SmartWear company; VOTwear?

While there are oceans of research available on their website, the brand seeks to do more than help you build big biceps quicker and easier. The goal of VOTwear is not only to provide innovative SmartWear, but also a format of expressing important values for individuals on a journey of seeking excellence, and redefining what we thought was written in stone.

Physiotherapy, de-loading, muscle-building, fat-loss, injury prevention, cardiac strength, these are few of many benefits BFRwear (blood flow restriction) has shown to provide, especially when combined with heavy weight training, does the HTM1 capacity seem to explode.

A young brand, but rooted in age old values of giving your purest and best- Less is more atvotwear.com

About VOTWEAR

VOTwear is a Norwegian SmartWear company, currently unveiling the worlds first venous occlusion training wear.

Read the original:
VOTwear- Pushing The Boundaries Of Training Wear. - PRUnderground

In 2014, shortly after a TKO loss to Michael Bisping in Macau, Cung Le tested positive for elevated levels of Human Growth Hormone (HGH). The UFC promptly handed Le a nine-month suspension, which was later elevated to a twelve-month term.

Fight fans were quick to pile-on and vilify Lebut things were not as cut-and-dry as they seemed.

In the weeks following Les failed drug test, it became clear that his result was due to a handful of errors and oversights on the part of the UFC and its partners.

While operating in Macau, which does not have its own athletic commission, the UFC operated as its own governing body, and hired a local testing facility to undertake anti-doping measures. As it turned out, this facility was not WADA-approved, and made a number of key errors in its testing proceduresmost notably testing Le after a gruelling fight, at which point HGH levels would naturally be higher.

They said I took HGH, Lee recounted on the latest episode of BJPENN.com Radio. Dr. [Don] Caitlin, an Olympic testing specialist, didnt stick up for me because he knew me or liked me. He stuck up for his 10 years of research saying that UFCs claims against me for taking HGH were wrong.

If youre doing testing, you have to test when [the test subject] is fasted and when their resting heart rate is normal or when they just woke up, Le continued. They literally tested me and Michael right after the fight. I was clean of everything else. I even took another test and put it out there and compared the two tests. Of course my HGH level was spiked because I literally got blood drawn out of me right after the fight. They pulled me back to the bathroom when I was all bloody, I actually had just lost the fight. I went four and a half rounds against Michael Bisping. Of course my levels are going to be elevated. Im bleeding out of my face, the bone underneath my eye was broken. So my body was trying to heal itself right then and there, of course my HGH levels going to be through the roof. And then for them to throw me under the bus

Cung Le continued, explaining that his and Bispings tests were destroyed immediately after the fact, which also damaged the credibility of the claims against him.

I asked them, hey, wheres Michaels test? [I said] I want to do the blood test again, lets do it again. Theyre like, Oh, its been destroyed. So right there I knew if youre not on their team, if youre not with them, youre against them.

Just prior to his fight with Bisping, Le had been offered a new eight-fight deal with the UFC. He says he declined to sign it because he wasnt able to connect with his lawyer, but the UFC encouraged him to sign anyway, evidently upset by his reluctance.

Right before I left, they wanted me to sign another eight-fight deal, Le said. I wouldve signed it. I was already thinking of moving down in weight, because all these guys [at middleweight] are so huge.

I mentioned that to Dana[ white], he added. I didnt sign my deal memo right then and there, because my lawyer was out of town. They wanted me to sign it right then and there, like literally the day before I flew out to Vietnam to finish up my training camp so I could acclimate to the time in China.

Les failed drug test and resulting suspension were ultimately rescinded for precisely the reason he describes above. After this fiasco, however, he decided against signing a new deal with the UFC, and instead requested his release from the promotion.

He has not fought since.

Today, Cung Le is involved in an anti-trust lawsuit against the UFC. Hes also working as a brand ambassador for a new combat sports promotion called EKIC, which places significant importance on treating fighters properly.

Give EKIC a follow on social media! Twitter / Facebook / InstagramCheck out their site here EKICLLC.COM

View original post here:
Cung Le looks back on drug-testing fiasco with UFC: They threw me under the bus - BJPENN.COM

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