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Lily Munster Weight Loss 2012 Lily Munster Diet Plan - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on. If you lose a lot of weight in a short time, staying the same size will be impossible unless you follow a maintenance program for life. Good, sensible dieting means skill and will power combined. A lot of these celebrity diets or Hollywood diets are very bad for the body and the celebrities are thinking of the camera rather than their long term health. Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

"Click Here to Download The Lily Munster Diet Programs - Get a Great Body Like Lily Munster in Days!"

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Lily Munster Weight Loss 2012 Lily Munster Diet Plan

Charlize Theron Weight Loss 2012 Charlize Theron Diet Plan - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on. If you lose a lot of weight in a short time, staying the same size will be impossible unless you follow a maintenance program for life. Good, sensible dieting means skill and will power combined. A lot of these celebrity diets or Hollywood diets are very bad for the body and the celebrities are thinking of the camera rather than their long term health. Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

"Click Here to Download The Charlize Theron Diet Programs - Get a Great Body Like Charlize Theron in Days!"

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Charlize Theron Weight Loss 2012 Charlize Theron Diet Plan

Bethenny Frankel Weight Loss 2012 Bethenny Frankel Diet Plan - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on. If you lose a lot of weight in a short time, staying the same size will be impossible unless you follow a maintenance program for life. Good, sensible dieting means skill and will power combined. A lot of these celebrity diets or Hollywood diets are very bad for the body and the celebrities are thinking of the camera rather than their long term health. Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

"Click Here to Download The Bethenny Frankel Diet Programs - Get a Great Body Like Bethenny Frankel in Days!"

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Bethenny Frankel Weight Loss 2012 Bethenny Frankel Diet Plan

A new surgical weight-loss procedure is now available to women who are looking to slim down and lose 25 to 70 pounds.

Dr. Tom Lavin, founder ofSurgical Specialists in Louisiana, is a pioneer behind the hottest new weight-loss procedure called POSE, which stands for primary obesity surgery endoluminol.

POSE is for patientswho want to lose 25-50, maybe 60 or 70 pounds, says Lavin. Its a much different group of people than we normally approachfor bariatric surgery.

POSE is like the classic bypass operation, but there are no incisions, as everything is done through the mouth using an endoscope. The surgical tools make the stomach about 30 percent smaller, says Lavin, and the patient typically goes home the same day.

Krystal Townsend, 34, had struggled with her weight most of her life and was not happy with who she was. She weighed 229 pounds before she paid a visit to Lavin. After POSE, she says, she has a new lease on life.

It was amazing, says Townsend. I didnt have any pain or any nausea, or any of the things that you hear about with some of the other procedures that are done.

Eve Talley, like most women, had tried diets for years but never got the results she wanted. Talley lost 12 pounds a month after undergoing surgery.

Im just tired of wearing a size 14 bathing suit. I want to wear a 6 or 7 like everybody else, says Talley.

Lavin doesntbelieve that surgery is too extreme to lose only 25 to 30 pounds of weight.

People get liposuction all the time, and they might lose 4 pounds of fat,says Lavin. I dont think this is nearly as strange.

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New Weight-Loss Surgery to Lose 20-50 Pounds

Newswise PHILADELPHIA -- June 12, 2012 -- A study by a team of clinicians and researchers at the Joslin Diabetes Center in Boston has shown for the first time that patients with diabetes who enrolled in a short-term intensive weight management program were able to lose weight and keep it off on their own for four years. The findings suggest an alternative course to bariatric surgery in the fight against type 2 diabetes.

The study, presented as a late-breaking abstract Sunday at the American Diabetes Associations 72nd Scientific Sessions, strongly counters the popular view that people generally cannot maintain long-term the weight loss achieved during lifestyle intervention programs.

The notion that most people in the medical field have is that when you apply intensive lifestyle interventions, the majority of patients gain all or most of the weight back in a year, said Osama Hamdy, M.D., Ph.D., Medical Director of the Obesity Clinical Program and Director of Inpatient Diabetes Management at Joslin and lead author of the paper.

People have been pessimistic, he added. They think they may need bariatric surgery. But we are sending an optimistic message. Think again. There is something else that can work effectively in real-world clinical practice and save money too. This is a very important observation.

The study showed that around 50 percent of the 120 patients who enrolled in the Weight Achievement and Intensive Treatment (Why WAIT) program for 12 weeks were able to maintain an average of 9.5 percent weight loss at four years, while the total group maintained 6.3 percent at four years.

Why WAIT is a multidisciplinary diabetes weight management program designed for clinical practice. The program included a change in diabetes medications to enhance weight reduction, structured dietary intervention with lower carbohydrates and higher protein and meal replacement, an exercise program, with emphasis on strength training and weekly educational and support sessions.

Although subjects in this study were followed for four years, they were on their own after the initial 12-week program. The study found that about half of the subjects did not regain the weight -- on average 24 pounds -- after four years. This group also maintained a significant improvement in their metabolic control as measured by hemoglobin A1c and the improvement in other vascular risk factors like blood pressure and lipids.

It also found that those who maintained at least seven percent of their weight loss at one year were most likely to continue the weight reduction over the long term.

This is very important information, Dr. Hamdy said. It tells us not everyone gains the weight back. In reality, these are similar numbers to the weight loss gained by some bariatric surgeries at that time frame.

Those who had lost at least seven percent of their body weight after one year lost an average of 29 pounds -- or 11.9 percent of their body weight -- at 12 weeks and maintained an average loss of 31.5 pounds -- or 12.6 percent -- at one year.

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Short-Term Intensive Weight Loss Program Works for Four Years; Valid Option Seen to Bariatric Surgery

Manny Pacquiao Weight Loss 2012 Manny Pacquiao Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

Read the original post:
Manny Pacquiao Weight Loss 2012 Manny Pacquiao Diet Programs

Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

Original post:
Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs

Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

Read more from the original source:
Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs

Katy Perry Weight Loss 2012 Katy Perry Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

Read more here:
Katy Perry Weight Loss 2012 Katy Perry Diet Programs

PHILADELPHIA--(BUSINESS WIRE)--

Amylin Pharmaceuticals, Inc. (AMLN) and Alkermes plc (ALKS) today announced results from the long-term extension of the DURATION-1 study, which showed that BYDUREON (exenatide extended-release for injectable suspension), the first and only once-weekly treatment for type 2 diabetes, was associated with clinically significant and sustained improvements in glycemic control during four years of treatment in adults with type 2 diabetes.

In the study, being presented at the 72nd Scientific Sessions of the American Diabetes Association in Philadelphia, patients completing four years of BYDUREON treatment experienced clinically significant improvements in A1C (1.7 percentage points) and fasting plasma glucose (-37 mg/dL) from baseline. A1C is a measure of average blood sugar over three months. Although BYDUREON is not indicated for weight loss, patients treated with BYDUREON also lost an average of 5.5 pounds from baseline.

In this study, patients treated with just one dose per week of BYDUREON for four years experienced sustained improvement in glycemic control and showed reductions in certain cardiometabolic measures. The tolerability of BYDUREON also improved over time with long-term treatment, said Christian Weyer, M.D., senior vice president, research and development, Amylin Pharmaceuticals. The durability of treatment effectiveness and tolerability of BYDUREON are critically important in managing the chronic and progressive condition of type 2 diabetes.

Patients treated with BYDUREON also experienced statistically significant reductions in certain cardiovascular risk markers, including systolic blood pressure (-1.6 mmHg), total cholesterol (-10.9 mg/dL), LDL cholesterol (-8.0 mg/dL) and triglycerides (-13 percent). No unexpected safety findings were observed with long-term BYDUREON therapy, and incidence of mild nausea, the most common adverse event during the controlled portion of the study, decreased over time (27 percent weeks 1-30; 1.6 percent weeks 180-212).

Study Details DURATION-1 compared the efficacy of once-weekly BYDUREON against twice-daily BYETTA (exenatide) injection in a 30-week, randomized, open-label study. Following the controlled portion of the study, 258 of the 295 intent-to-treat patients (87 percent) entered the extension study. A total of 68 percent of patients (n=176) completed four years of treatment, 55 percent of whom achieved the ADA-recommended A1C target of less than 7 percent. Primary endpoints were change from baseline to year four in A1C, and long-term safety and tolerability.

About BYDUREON (exenatide extended-release for injectable suspension) BYDUREON is the first and only once-weekly medicine to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes. It is a once-weekly formulation of exenatide, the active ingredient in BYETTA (exenatide) injection, which has been available in the U.S. since June 2005 and is used in nearly 80 countries worldwide. BYDUREON works with the body to help make its own insulin when needed, providing continuous glycemic control with just one dose per week. Using Alkermes proprietary technology for long-acting medications, the biodegradable microspheres in each dose of BYDUREON provide a controlled release of exenatide throughout the week. BYDUREON was approved in the U.S. in January 2012 and in Europe in June 2011.

BYDUREON is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise. BYDUREON is not recommended as the first medication to treat diabetes.

BYDUREON and BYETTA both contain the same active ingredient, exenatide, and therefore should not be used together. BYDUREON is not insulin and should not be taken instead of insulin. BYDUREON is not for people with type 1 diabetes or people with diabetic ketoacidosis. BYDUREON is not recommended for use in children. It is not known if BYDUREON is safe and effective in people with a history of pancreatitis or severe kidney problems. See important safety information below. Additional information about BYDUREON is available at http://www.BYDUREON.com.

Important Safety Information for BYDUREON (exenatide extended-release for injectable suspension)

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BYDUREON™ Was Associated with Significant and Sustained Glycemic Control at Four Years

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