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YouTuber Brendan Jones has been on a body transformation journey recently, leaning down and getting ripped in 2021but his journey has been a long one, starting way back in 2016 when he first started undertaking workout challenges on the Goal Guys channel. In a new video, Jones shares what he's learned over the last five years, including the rookie errors that held back his gains at first.

The first mistake that he made was trying to do too much too soon, including making drastic changes to his diet. "Starting out as a new lifter, I was so eager to add size that I interpreted any increase on the scale as a sign that my muscle gains were coming in," he says. "And why shouldn't they be? I was clean bulking with an ever-increasing calorie surplus, and training as hard as I ever had in the gym."

While the research would indicate that Jones could expect to gain a maximum of 1 or 2 pounds per month this way, he was gaining upwards of 4 pounds each month. "My calorie surplus was so intense, my body was converting more and more of those calories into fat," he says. When he tried to counteract this by upping his cardio and reducing his calorie intake, he did lose weightbut that included a loss in muscle mass as well as fat.

Jones recognizes now that he shouldn't have been thinking in terms of bulking or cutting so early, and that cleaning up his nutrition on top of his training would have put him in a "perfect spot" to build muscle while burning fat.

Jones' second major mistake was a lack of accountability, whether in the form of a trainer or workout buddy, which he now believes to be one of the best ways of ensuring success in your fitness goals. "It's silly that even as an adult, I'm still motivating myself with the equivalent of getting a gold star from the teacher, but having that social incentive to follow through really does make the difference between skipping a workout once a week or actually getting the workout done," he says. "And those small victories over time actually add up to significant improvements in your final results."

The third mistake Jones made in the early stages of his journey was to prioritize the short-term wins over his long-term objectives. Rather than sticking to intensely restrictive diets, he now tries to build more sustainable habits that he can stick to permanently. These include coming up with go-to meals that enable him to hit his macro and calorie targets, going for a 30-minute morning walk, carving out 30 minutes each evening for a workout, and trying to get a minimum of 7 hours of sleep.

Finally, Jones explains that it was only once he started being able to recognize how "invisible" external factors were affecting him that he began to see real changes. These can be anything from the length of a morning commute, to the number of fast food restaurants in a neighborhood. Jones found that the amount of time he was spending sitting in traffic (and the snacking he would do in the car) was contributing to his stress levels and sedentary lifestyle.

"Understanding what environmental factors may be affecting you and the goals you're working towards can help you form better plans to adjust, find strategies to cope, and maybe adjust your timeline if it looks like the goal weight you set for yourself may take longer than you expected," he says. "All this is part of the process of training smart, making the right adjustments as you go, and learning from your mistakes."

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An Average Guy Shared All the Mistakes He Made While Trying to Stay Shredded - Men's Health

ROCHESTER Becky Hubbard married her husband, Jarrett, in a small intimate courthouse ceremony in January 2020.

The newlyweds plan was to hold a celebration later in the year, but then COVID-19 hit. And like so many other well-laid plans, the Hubbards wedding celebration was put on ice.

But unlike a lot of people, who went on high-caloric eating binges to cope with the stress, Hubbard, 38, used the pandemic as a pretext to go on a diet. It was not her first attempt.

The Rochester woman figures that she has been dieting off and on since her late teens. She tried starving herself, Weight Watchers, and milkshakes. Paleo dieting provided the best results, but like her previous attempts, the weight loss proved to be temporary.

I found that over time, paleo was too restrictive for me to carry it long term, said Hubbard, a Minnesota Department of Transportation environmental document writer.

Contributed / Mayo Clinic

At the beginning of the year, Hubbard tried again, hitting upon a combination of motivations that ended up providing more long-lasting results. Hubbard knew she wanted to have kids and that having kids required a level of healthiness that had eluded her most of her adult life.

Another motivating factor was the pandemic itself. Having been obese most of her life, Hubbard knew that her weight was a risk factor for severe illness or even death if she caught the disease.

Today, Hubbard can no longer wear the beautiful dress that she wore on her wedding day because its too big. She estimates having lost nearly 50 pounds, dropping from nearly 300 pounds to 240.

Hubbards experience ran counter to the experiences of many adults, who found that their waistlines expanded during the pandemic. Nearly half of U.S. adults put on excess pounds during the first year of the pandemic, making a national obesity crisis worse, a new study found.

Other benefits for Hubbard have included a lower, more stable blood sugar level. Hubbard tracks her exercises through a fitness watch and has noticed how her resting heart rate has dropped to a lower level. Her cholesterol levels have also gone down a few points another good sign because high cholesterol runs in her family history.

Joe Ahlquist / Post Bulletin

Hubbards experience in terms of her motivation for losing weight has found echoes in other dieters. In a weight loss survey of 200,000 consumers on the Mayo Clinic Diet, the official dietary program developed by Mayo Clinic, considerations of health were a key motivator.

About 83% of participants valued health above all other aspirations, which is consistent with global health trends post-COVID. Health surpassed physical appearance as a motivating factor by more than five times. More than 55% of participants had dieted at least six times during their lifetimes, a sign that Americans are seeking sustainable solutions to healthy weight management, the study's author said.

Its rather a unique survey because of its large scale, and that it explores the psychology of a dieters mindset, said Donald Hensrud, medical editor of The Mayo Clinic Diet. We wanted to learn more about the motivations and aspirations around weight loss, and if a stage of readiness or sense of identity played a role in a diet programs results.

Hubbard said Mayo Clinic Diet originated as a book series and now exists on a new online platform that gives you a lot more tools and features five different meal plans. For Hubbard, the Mayo diet differed from others she tried in that it not only gave recommendations but offered rationales behind those recommendations.

I was looking this time for something that would give me that educational piece about nutrition that I felt like I was missing, Hubbard said. I really felt like I wouldnt be able to carry anything forward without having that solid education first.

Joe Ahlquist / Post Bulletin

Hubbard said the Mayo program educated her about portion and serving sizes and the number of calories in each serving. It gave her tools to track her food intake, as well as ways to monitor the pounds and inches lost. Hubbard is on a high protein plan.

Hubbard found the Mayo diet enlightening in terms of what had contributed to her previous weight loss failures. In all her previous efforts, Hubbard recalled experiencing horrible sugar cravings'' that ended up derailing her best intentions. This time, she went through what she called a two-week sugar detox.

It took me a while for me to come off of that. And as soon as I hit those two weeks, my sugar cravings essentially went away, she said. I didnt realize I had such a sugar addiction before this diet until I went through that detox period.

Hubbard said another reason she has been successful over the last several months is the programs flexibility. Instead of imposing a restrictive, all-or-nothing eating regimen, there is room within the programs boundaries to eat the foods she loves within reason.

Joe Ahlquist / Post Bulletin

She can still have a piece of cake at a friends birthday party or eat a square of Dove Chocolate every now and then.

Its flexible enough that you can still enjoy some of the things that you really, really love, Hubbard said. You dont have to just give something up because youre dieting.

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When COVID-19 hit, this Rochester woman decided to go on the 'Mayo Clinic diet' - Rochester Post Bulletin

Rebel Wilson has been dropping jaws and inspiring fans with her amazing weight loss over the past couple of years, and now shes done it again with a big announcement. The Senior Year actress celebrated Pride Month with some personal news, as she came out on June 9 by sharing a cute photo to Instagram of her with girlfriend Ramona Agruma.

Ramona Argruma is the owner of Lemon Ve Limon, a sustainable clothing brand based in Los Angeles. Its unknown how long Rebel Wilson and the clothing and jewelry designer have been a couple, but their smiles on the Instagram photo are all we need. Take a look at the surprising and adorable announcement below:

Happy Pride, indeed! The caption on Rebel Wilson's post says she thought she was looking for a Disney prince, when maybe what she needed all this time was a Disney princess. How sweet! She also left heart and rainbow emojis on her post, with the hashtag #loveislove.

TMZ reports Rebel Wilson and Ramona Agruma were spotted together at the Super Bowl in Los Angeles in February. The newly announced couple also went to Cabo in March with a group of friends to celebrate the Pitch Perfect actress' 42nd birthday.

The comedian is known to stay pretty private about her love life. She dated Jacob Busch for a few months in 2020-2021, but People reported they broke up because "he was not the one for her long term." US Weekly reports Rebel Wilson also split from comedian Mickey Gooch Jr. in 2015 after dating for only a few months and also briefly dated stuntman Aden Stay in 2017.

Rebel Wilson has been motivating fans with inspiring stories about her Year of Health, in which she lost over 70 pounds in 2020 to reach her goal weight and maintain it over the next couple of years.

The actress has opened up about her weight loss journey, which started after a doctor offended her during a visit in which she was talking about fertility and family planning. But in her journey to better health, she got pushback from her team, who questioned why she would want to change her life when she'd found so much success as the "funny fat girl." Her most famous role, probably still to date, is "Fat Amy" from the Pitch Perfect movies, but after her incredible weight loss, she's got a new nickname "Fit Amy."

Fans got to see the result of all her hard work last month, when Senior Year was released to Netflix subscribers. It was the actress first movie since appearing in Isnt It Romantic, The Hustle, Jojo Rabbit and Cats, all in 2019.

Hopefully Rebel Wilson will continue to share updates on her new relationship with "Disney princess" Ramona Agruma, because this is a fairy tale fans definitely want to see more of!

Along with Senior Year, see what other movies to stream on Netflix, and be sure to check out our 2022 Movie Release Schedule, if youd like to start planning your next trip to the theater.

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Rebel Wilson Reveals She Has A Girlfriend With Sweet Photo, And Happy Pride - CinemaBlend

Whats the trend? This trend hits close to homemy teenage daughter came home from varsity volleyball practice asking if I could buy her a Celsius energy drink after her interest was piqued from its popularity on TikTok. The Celsius energy drink has become popular in high school, college and among adult athletes, as the company claims that it provides essential energy, accelerates metabolism and helps burn body fat.

The truth behind the trend: Research suggests that energy drinks can be harmfulone 2019 study found that energy drinks can raise blood pressure, and others have linked their consumption to headaches, stomachaches, hyperactivity and insomnia.

Celsius and other energy drinks contain several stimulants, including caffeine and guarana extract. Guarana is a compound with roughly four times more caffeine than coffee beans. Excessive amounts of caffeine can lead to increased anxiety, insomnia, heart problems and an upset stomachand while Celsius Heat has 300 milligrams of caffeine (and the U.S. Food and Drug Administration suggests 400 milligrams is safe to consume), this would almost max you out for caffeine intake for the day. Celsius also contains taurine, which is used to treat high blood pressure and congestive heart failure, however, there is little to no research on the safety of taurine when taken in high doses or for longer periods of time.

Try or skip? Skip this one. There are much better ways to get energy then by adding lots of caffeine and other, non-scientifically sound ingredients to your workout regimen. Water tends to be your best bet when exercising moderately, and if you do need extra electrolytes or fluids, usually if youre exercising over an hour or if the weather is very hot, I recommend coconut water or Gatorade.

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Skip Or Try These 5 Nutrition TikTok Trends, According To A Registered Dietitian - Forbes

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Fasting sends muscle stem cells into a deep resting state that slows muscle repair but also makes them more resistant to stress, according to a study of laboratory mice.

The protective effect can also be achieved by feeding the mice high-fat, low-carbohydrate foodalso known as a ketogenic dietthat mimics how the body responds to fasting, or by giving the animals ketone bodies, the byproducts that occur when the body uses fat as an energy source.

The research explores how the body responds in times of deprivation and plenty and gives clues about the effect of aging on the ability to regenerate and repair damaged tissue. Although the study focused on muscle stem cells, the researchers believe the findings are applicable to other types of tissue throughout the body.

As we age, we experience slower and less complete healing of our tissues, says Thomas Rando, professor of neurology and neurological sciences at Stanford University. We wanted to understand what controls that regenerative ability and how fasting impacts this process. We found that fasting induces resilience in muscle stem cells so that they survive during deprivation and are available to repair muscle when nutrients are again available.

Rando, who recently accepted a position as the director of the Broad Stem Cell Research Center at UCLA, is the senior author of the study in Cell Metabolism. Instructor Daniel Benjamin and graduate student Pieter Both are the lead authors of the study.

Its been well documented that long-term caloric restriction extends the lifespan and promotes the overall health of laboratory animals, but it is difficult for people to maintain a very-low-calorie diet for months or years. Periodic fasting has been explored as another way to obtain the health benefits of caloric restriction, but the effects of intermittent fasting on the body and its ability to regenerate damaged or aging tissues have not been well studied.

Fasting or, alternatively, eating a ketogenic diet high in fat and low in carbohydratesa popular weight-loss techniquecauses the body to enter a state called ketosis, in which fat is the primary energy source. Ketone bodies are the byproducts of fat metabolism.

The researchers found that mice that had fasted between 1 and 2.5 days were less able than non-fasting animals to regenerate new muscle in their hind legs in response to injury. This reduced regenerative capacity persisted for up to three days after the mice began feeding again and returned to a normal body weight; it returned to normal within one week of the end of the fast.

Further research showed that muscle stem cells from fasting animals were smaller and divided more slowly than those from non-fasting animals. But they were also more resilient: They survived better when grown on a lab dish under challenging conditions including nutrient deprivation, exposure to cell-damaging chemicals, and radiation. They also survived transplantation back into animals better than those from non-fasting animals.

Usually, most laboratory-grown muscle stem cells die when transplanted, Rando says. But these cells are in a deep resting state we call ketone-induced deep quiescence that allows them to withstand many kinds of stress.

Muscle stem cells isolated from non-fasting animals and then treated with a ketone body called beta-hydroxybutyrate (BHB) displayed a similar resilience as did those from fasting animals, the researchers found. Additionally, muscle stem cells isolated from mice fed a ketogenic diet, or a normal diet coupled with injections of ketone bodies, displayed the same characteristics of the deeply quiescent stem cells from fasting animals.

Finally, the researchers isolated muscle stem cells from old mice that had been treated with ketone bodies for one week. Previous research in Randos lab showed that these aged muscle stem cells grew more poorly in the laboratory than muscle stem cells from younger animals. But treatment with the ketone bodies allowed the old muscle stem cells to survive as well as their younger counterparts.

Although more research needs to be done, the results are intriguing, the researchers say.

Cells evolved to exist in times of abundance and in times of deprivation, Rando says. They had to be able to survive when food was not readily available. Ketone bodies arise when the body uses fat for energy, but they also push stem cells into a quiescent state that protects them during deprivation. In this state, they are protected from environmental stress, but they are also less able to regenerate damaged tissue.

Balancing these outcomes might one day help combat normal aging and enhance stem cell function throughout the body, the researchers speculate.

It would be beneficial if the effects of fasting on stem cells could be attained through ketone bodies, supplanting the need to fast or to eat a ketogenic diet, Rando says. Perhaps it may be possible to eat normally and still get this increased resilience.

The National Institutes of Health, the Buck Institute for Research on Aging, and the Department of Veterans Affairs supported the work.

Researchers from UC Berkeley, the Veterans Affairs Palo Alto Health Care System, and the Mondor Institute for Biomedical Research in France are coauthors of the study.

Source: Stanford University

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Fasting has pros and cons for muscle repair in mice - Futurity: Research News

HANGZHOU, China and SAN FRANCISCO, June 8, 2022 /PRNewswire/ -- Sciwind Biosciences Co., Ltd., a clinical-stage biopharmaceutical company focusing on discovering and developing innovative therapies to treat metabolic disease, today announced that two abstracts have been accepted for poster presentations at The International Liver CongressTM 2022, the Annual Meeting of the European Association for the Studies of the Liver (EASL) taking place June 22-26 in London, United Kingdom. During the meeting, data from a combination study of Sciwind's long-lasting GLP-1 peptide analog XW003 and GIP peptide analog XW017 in an obese mouse model and preclinical pharmacology data for the oral small molecule GLP-1 receptor agonist XW014 will be featured in two poster presentations.

"We are excited to have an opportunity to present the recent data from our GLP-1 and GIP receptor agonist programs at this prestigious international conference," said Xinle Wu, PhD, Chief Scientific Officer of Sciwind. "We believe that these data lend strong support to Sciwnd's long-term strategy to develop more efficacious, better tolerated and more convenient treatment options for patients living with metabolic disease."

Presentation Details:

Poster Title: Synergistic activity of GLP-1 peptide analog XW003 and the long-lasting GIP receptor agonist XW017 in a diet induced obese mouse modelPublication Number: 1391Session Title: NAFLD: TherapyDate: Saturday June 25 between 9AM 6PM GMTPoster Title: Preclinical pharmacology of low molecular weight GLP-1 receptor agonist XW014Publication Number: 1399Session Title: NAFLD: TherapyDate: Saturday June 25 between 9AM 6PM GMT

About XW003

Injectable GLP-1 analogs are effective tools in managing type 2 diabetes, obesity, and have demonstrated clinical potential as a treatment for NASH. XW003 is a novel, biased long-lasting GLP-1 peptide analog optimized for improved biological activity, cost-effective manufacturing, and once weekly dosing. XW003 has been shown to be safe and well tolerated in Phase 1 clinical study. Phase 2 studies are underway to study XW003 as a potential treatment for type 2 diabetes and obesity.

About XW014

XW014 is a small molecule GLP-1 receptor agonist with the potential to be dosed orally once a day. Compared with GLP-1 peptide analogs, this small molecule agonist is easier to manufacture and formulate for oral dosing. As a small molecule, XW014 has the potential to be co-formulated with other oral drugs of complementary mechanisms to create more effective combination treatments for obesity, type 2 diabetes, and NASH. XW014 is slated to enter clinical trials in Q3 2022.

About XW017

In combination with GLP-1 analogs, injectable GIP receptor agonists have demonstrated improved glycemic control, as well as more profound weight loss, in clinical trials. XW017 is a novel, long-lasting GIP peptide analog optimized for biological activity and in vivo stability. It has the potential to be co-formulated with GLP-1 analogs to generate more effective combination treatments for obesity, type 2 diabetes, and NASH. XW017 is anticipated to enter clinical trials in 1H 2023.

About Sciwind

Sciwind Biosciences is a clinical stage biopharmaceutical company focusing on discovering and developing innovative therapies to treat metabolic disease. Its product pipeline consists of potentially first-in-class and best-in-class drug candidates. Sciwind has developed multiple proprietary technologies, including oral peptide and inhaled protein therapeutic delivery platforms and identified a series of drug candidates based on these core platform technologies. For more information, visit http://www.sciwindbio.com.

View original content:https://www.prnewswire.com/news-releases/sciwind-biosciences-to-present-data-from-its-glp-1-and-gip-receptor-agonist-programs-at-the-international-liver-congresstm-easl-2022-301562457.html

SOURCE Hangzhou Sciwind Biosciences Co., Ltd.

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Sciwind Biosciences to present Data from its GLP-1 and GIP Receptor Agonist Programs at The International Liver Congress(TM) EASL 2022 - BioSpace

SAN FRANCISCO and SUZHOU, China, June 7, 2022 /PRNewswire/ --Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, autoimmune, metabolic, ophthalmology and other major diseases, announces that the primary and all key secondary endpoints were met in a randomized, double-blind, placebo-controlled phase 2 study of mazdutide (R&D code: IBI362), a glucagon-like peptide-1 receptor (GLP-1R)/glucagon receptor (GCGR) dual agonist, in Chinese participants with overweight or obesity.

This study (ClinicalTrials.gov, NCT04904913) was designed to evaluate the efficacy and safety of mazdutide in Chinese participants with overweight or obesity. A total of 248 subjects were randomized to receive 1.5-3.0 mg, 1.5-3.0-4.5 mg, or 2.0-4.0-6.0 mg of mazdutide or placebo subcutaneously and once-weekly for 24 weeks. The primary endpoint was the percentage change from baseline in body weight at week 24. A total of 230 participants (92.7%) completed week 24.

Mazdutide demonstrated superior weight loss efficacy in Chinese participants with overweight or obesity compared with placebo in a dose-dependent manner. After 24 weeks of treatment:

Meanwhile, mazdutide markedly reduced body-mass index, waist circumference, liver fat content and blood pressure; lowered lipid, transaminase and serum uric acid levels, and improved insulin sensitivity, delivering comprehensive metabolic benefits for participants with overweight or obesity.

In terms of safety, mazdutide was well tolerated. Only one participant discontinued the treatment due to an adverse event, which was not related to mazdutide as judged by the investigator. The overall safety profile was similar to those observed in early phase development and with other GLP-1-based agonists and co-agonists. The most frequently-reported treatment-emergent adverse events were diarrhea, nausea and upper respiratory tract infection, mostly mild or moderate in severity and transient.

Professor Linong Ji, the principal investigator of the study, Peking University People's Hospital, stated," In recent years, the prevalence of obesity in China has increased rapidly and resulted in the increase of the prevalence of diabetes, fatty liver, sleep disorders and cardiovascular diseases. Therefore, effective and safe weight-loss drugs are urgently needed. We are pleased to see the exciting results of the phase 2 study of mazdutide in Chinese participants with overweight or obesity, suggesting that mazdutide could potentially be the best-in-class agent. The half-year treatment of mazdutide achieved on average 12.6% weight reduction from baseline compared with placebo, which was comparable to the most cutting-edge weight-loss drugs under development in the world. The excellent efficacy of mazdutide in weight loss and multiple metabolic parameters truly reflects the advantages of weekly formulation based on dual incretin receptor agonists. I am confident and looking forward to the success of mazdutide in the upcoming phase 3 study."

Dr. Lei Qian, Vice President of Clinical Development of Innovent,stated, "The Phase 2 study of mazdutide in Chinese participants with overweight or obesity achieved the primary and all key secondary endpoints,while showing improvement on multiple metabolic parameters including blood pressure, lipids, transaminase and serum uric acid. These results demonstrate the great utility value of GLP-1R/GCGR dual agonist, further demonstrating the potential to be the best-in-class agent and paving solid foundation for further clinical development. Of note, the auto-injector has been used in the phase 2 studies, greatly improving the quality of life and compliance of participants, while demonstrating the quality and capability of domestic enterprises in device development and manufacturing; we will actively promote the development of phase 3 clinical study of mazdutide and anticipate more clinical data later this year, striving to provide more convenient, user-friendly, effective and safe drug for overweight and obese population as soon as possible."

* Due to the outbreak of Covid-19, the data are being collected and under further analysis. The data disclosed in this press release may have some deviation from the final results.

About Obesity

China has the largest obese population in the world, with obesity rate likely to increase. Obesity can lead to a range of complications or related diseases that impact life expectancy and lead to a decrease in quality of life. In more severely obese patients, the incidence and mortality of cardiovascular disease, diabetes, and certain tumors increase significantly. Obesity is a chronic disease that requires long-term management, and there is a lack of long-term effective and safe treatments. Lifestyle intervention is the first choice and basic treatment for patients with overweight or obesity. However, a considerable percentage of patients fail to achieve the desired weight loss goal upon lifestyle intervention due to various reasons and may require pharmacological intervention. Traditional anti-obesity drugs have limited weight-loss effects and are associated with safety issues.

About Mazdutide (IBI362)

Innovent entered into a licensing agreement with Eli Lilly and Company (Lilly) for the development and potential commercialization of OXM3 (also known as mazdutide), a GLP-1R and GCGR dual agonist, in China. In parallel, Lilly is developing OXM3 outside China. Mazdutide is a long-acting synthetic peptide related to mammalian oxyntomodulin (OXM), which uses a fatty acid side chain to prolong the duration of action and allow once-weekly administration. Mazdutide is thought to exert its biological effects by activating GLP-1 receptor and glucagon receptor in human beings, which improves glucose tolerance and induces weight loss, mimicking the effects of endogenous oxyntomodulin.

In addition to the effects of GLP-1 receptor agonists on promoting insulin secretion, lowering blood glucose and reducing body weight, mazdutide may also increase energy expenditure and improve hepatic fat metabolism through the activation of glucagon receptor. The treatment of metabolic diseases by activating multiple metabolism-related targets simultaneously is currently the worldwide trend in drug development.

About Innovent

Inspired by the spirit of "Start with Integrity, Succeed through Action," Innovent's mission is to develop, manufacture and commercialize high-quality biopharmaceutical products that are affordable to ordinary people. Established in 2011, Innovent is committed to developing, manufacturing and commercializing high-quality innovative medicines for the treatment of cancer, autoimmune, metabolic, ophthalmology and other major diseases. On October 31, 2018, Innovent was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code: 01801.HK.

Since its inception, Innovent has developed a fully integrated multi-functional platform which includes R&D, CMC (Chemistry, Manufacturing, and Controls), clinical development and commercialization capabilities. Leveraging the platform, the company has built a robust pipeline of 32 valuable assets in the fields of cancer, autoimmune, metabolic, ophthalmology and other major therapeutic areas, with 7 products approved for marketing in China TYVYT (sintilimab injection), BYVASDA (bevacizumab biosimilar injection), SULINNO (adalimumab biosimilar injection), HALPRYZA (rituximab biosimilar injection) , Pemazyre (pemigatinib oral inhibitor) and olverembatinib (BCR-ABL TKI)and Cyramza (ramucirumab), 2 asset under NMPA NDA review, 4 assets in Phase 3 or pivotal clinical trials, and an additional 19 molecules in clinical studies.

Innovent has built an international team with advanced talent in high-end biological drug development and commercialization, including many global experts. The company has also entered into strategic collaborations with Eli Lilly and Company, Adimab, Incyte, MD Anderson Cancer Center, Hanmi and other international partners. Innovent strives to work with many collaborators to help advance China's biopharmaceutical industry, improve drug availability and enhance the quality of the patients' lives. For more information, please visit: http://www.innoventbio.com. and http://www.linkedin.com/company/innovent-biologics/.

Note:

TYVYT (sintilimab injection) is not an approved product in the United States.

BYVASDA (bevacizumab biosimilar injection), SULINNO, and HALPRYZA (rituximab biosimilar injection) are not approved products in the United States.

TYVYT (sintilimab injection, Innovent) BYVASDA (bevacizumab biosimilar injection, Innovent)HALPRYZA (rituximab biosimilar injection, Innovent)SULINNO (adalimumab biosimilar injection, Innovent)Pemazyre (pemigatinib oral inhibitor, Incyte Corporation). Pemazyre was discovered by Incyte Corporation and licensed to Innovent for development and commercialization in Mainland China, Hong Kong, Macau and Taiwan.CYRAMZA (ramucirumab, Eli Lilly). Cyramza was discovered by Eli Lilly and licensed to Innovent for commercialization in Mainland China.

Disclaimer:

1. This indication is still under clinical study, which hasn't been approved in China.2.Innovent does not recommend any off-label usage.

Forward-looking statement

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to Innovent Biologics ("Innovent"), are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company's competitive environment and political, economic, legal and social conditions.

The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialise or turn out to be incorrect.

SOURCE Innovent Biologics

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Innovent Announces Phase 2 study of MazdutideIBI362 in Chinese Participants with Overweight or Obesity Met Primary and All Key Secondary Endpoints -...

It's an all-too-common story. A patient loses weight after changing his or her diet and physical activity.

Donna Ryan

Comprehensive lifestyle intervention (behavior changes around diet and physical activity) is foundational to weight loss efforts, including perhaps the addition of drugs, devices, or surgery. These interventions have been shown to produce weight loss associated with many health benefits, and medical cost savings.

The patient is delighted, feels better, and now "knows what to do" to avoid regaining weight. But in the reduced-weight state, the patient experiences biologic and physiologic changes that can't be perceived by them, but which drive weight regain.

Thus, we usually watch the patient slowly and inexorably regain all of the lost weight. This is demoralizing to patients, who frequently blame their "resolve." Understanding the biologic defense of body fat mass is essential to understanding the weight regain phenomenon and to helping patients succeed with long-term maintenance of weight loss.

When patients are at a reduced weight, we can measure changes in hormones of the gut-brain axis that regulate food intake, and we can measure changes in subjective reports of hunger around a meal. These changes drive increased food intake in the weight reduced state. We can also measure changes in resting metabolic rate and muscle efficiency caused by weight reduction, and this reduced energy expenditure also drives weight gain.

What is going on here?

Even the very best lifestyle interventions are associated with weight regain, usually beginning after 1 year. Adding physical activity produces more weight loss than diet alone, but both diet only and diet plus exercise strategies are challenged by weight regain. In fact, across 29 long-term weight loss studies, regain of more than half of the lost weight occurred by 2 years, and 80% of lost weight was regained by 5 years.

A seminal study by Sumithran and colleagues provides insight into the biology of weight regain, describing the effect of weight loss on gut hormone responses (which drive hunger and satiety). In this study, 50 patients who were overweight or obese entered a metabolic unit and received a very-low-energy diet for 10 weeks. The mean weight loss was 14%. Then, the participants were allowed to be free-living but continued counseling was provided to support weight loss maintenance. At week 62 (1 year out of the unit), weight regain was 5% on average, with the mean weight loss down to 8% from baseline.

The investigators assessed hormonal and appetite changes in response to the reduced weight state, first at 10 weeks and then at 62 weeks.

Researchers found that levels of leptin, the hormone produced by body fat that signals satiety, changed with weight loss. The 13% weight loss at 10 weeks led to a 64% reduction in leptin levels. And even with some weight regain, when weight loss was down to 8% at 62 weeks, the leptin level was still reduced by 35%.

When leptin levels fall, energy is conserved via a reduction in resting energy expenditure the body acts as if it is in starvation mode.

For other relevant hormones, weight loss at both 13% and 8% led to significant reductions in levels of peptide YY, cholecystokinin, insulin (P <.001 for all comparisons), and amylin (P =.002). These hormones also all promote satiety. Conversely, there was an increase in levels of ghrelin (P <.001) at both points, the hormone that promotes hunger. This would drive increased food intake.

Perhaps not unexpectedly, the study found an increase in subjective appetite that increased with weight loss.

Thus, patients with weight loss have a "double whammy": They have changes both in appetite regulation and energy expenditure that favor weight regain.

There is also no doubt that the modern environment is obesogenic. Changes in food and physical activity continue to drive increased intake, decreased activity, and ultimately weight gain. Behavioral factors may also play a role, and it is safe to say that we do not understand all of the factors that drive weight regain.

There are, however, some individuals who have been successful in maintaining large weight losses (> 30 lb) over 10 years. These individuals are part of the National Weight Control Registry (NWCR), which was founded in 1993 to identify successful weight-loss maintainers and describe strategies they use to achieve and maintain weight loss.

Although some weight regain occurred over time, these individuals were able to maintain 74% of their initial weight loss at 10 years, and 88% of them had maintained a 10% weight loss at year 10.

Noteworthy is that the individuals who had larger initial weight losses at entry into the NWCR maintained larger weight losses throughout the entire follow-up period. The participants reported high levels of physical activity (approximately 2000 kcal expended per week), low calorie and fat intake, high levels of dietary restraint, and low levels of disinhibition. In addition, most participants reported weighing themselves several times a week (Klem et al; McGuire et al; Thomas et al).

Understanding the physiologic, psychosocial, and environmental determinants of individual variability is an active area of obesity research.

The best and most important strategy is to continue patient contact after weight loss.

Medications approved for chronic weight management (orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, and semaglutide) promote weight loss maintenance if they are taken long-term. For all of the medications, studies of 3 years' duration document weight loss maintenance, as well as weight regain if the medications are discontinued.

Other important strategies include approaching maintenance differently from active weight loss. Dietary approaches and promoting physical activity, such as in the NWCR, would be useful. Other behavioral techniques such as cognitive restructuring (small weight gain is not failure and re-initiation of lifestyle measures is possible) and relapse prevention (maintaining contact with patients and not waiting until large regain has occurred to intervene) are also key.

Patients need to understand the challenges facing them, so do discuss the biological challenges that losing weight brings.

Don't let patients blame themselves. It is biology, not willpower! If you understand the biology of weight regain, you will expect patients to be challenged by regain and you can intervene early.

So first and foremost, keep the patients coming back.

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Continued here:
Why Is Long-term Weight Loss So Difficult? It's Biology, not Willpower! - Medscape

The 21-Day Smoothie Diet is a weight loss plan touted as an easy and effective alternative to fad diets.

In fact, the creator of the plan claims that the diet is associated with a long list of benefits and can help improve sleep, keep your skin glowing, skyrocket energy levels, and increase weight loss almost instantly.

However, there are several serious downsides associated with this program, and it may do more harm than good in the long run when it comes to your health.

This article will take a closer look at the 21-Day Smoothie Diet, how it works, and some of the negative risks and side effects it may be associated with.

The 21-Day Smoothie Diet is a weight loss plan developed by health coach Drew Sgoutas.

The plan involves swapping two of your meals each day with smoothies, and the principles of the program are outlined in the e-book, The Smoothie Diet, which is available online for $47.

The e-book includes 36 smoothie recipes, meal and snack ideas, shopping lists, weekly schedules, and tips for preparing the smoothies and maintaining weight loss long-term.

According to Sgoutas, the 3-week diet plan can help promote healthy eating, enhance immune function, detoxify the body, improve skin and gut health, and rev up energy levels.

Sgoutas also claims that the diet can boost weight loss. In fact, some testimonials displayed on the website claim that the plan led to up to 9 pounds (4 kg) of weight loss in just 3 days.

The 21-Day Smoothie Diet is a 3-week diet plan that involves replacing two meals per day with smoothies. The program claims to enhance immunity, boost energy levels, improve skin and gut health, and increase weight loss quickly.

The 21-Day Smoothie Diet involves replacing two of your meals each day with smoothies using the recipes found in the e-book.

There are 36 recipes provided in the book, created using ingredients like fruits, vegetables, nuts, seeds, and almond or coconut milk.

In addition to these two smoothies, the plan allows you to eat one solid meal per day and two healthy snacks.

Solid meals should consist mostly of whole foods, and snacks should be low in sugar and high in fiber, with around 150200 calories per serving.

You are also allowed one cheat day per week where you dont consume any smoothies, though meals should still consist mostly of whole, minimally processed foods.

Optionally, you can kick off the plan with a 3-day detox, which requires you to consume a smoothie in place of all three daily meals, with two healthy snacks in between.

According to the programs website, the diet works by creating a calorie deficit, meaning that you are expending more calories than you consume each day.

The diet is also high in fiber and claims to help reset your taste buds to reduce sugar cravings.

The program is intended to be followed for 3 weeks but can be repeated as many times as needed until you reach your goal weight.

The 21-Day Smoothie creates a calorie deficit by replacing two of your meals with smoothies and eating one solid meal and two snacks per day. The plan should be followed for 3 weeks and can be repeated as many times as needed.

The 21-Day Smoothie Diet encourages nutrient-dense foods like fruits and vegetables while limiting processed ingredients.

Most of the smoothie recipes included in the 3-week program consist of fruits, vegetables, nuts, and seeds, mixed with coconut milk, coconut water, or almond milk.

Additionally, the plan emphasizes whole, minimally processed foods for your remaining meals and snacks while following the diet.

Some specific examples of foods that are encouraged on the 21-Day Smoothie Diet:

On the 21-Day Smoothie Diet, you should limit your intake of sugar-sweetened beverages and processed foods, including processed meat, refined grains, and fried foods.

Here are some examples of foods to limit or avoid while following the diet:

Whole, minimally processed foods are encouraged on the 21-Day Smoothie Diet, including fruits, vegetables, nuts, and seeds. Meanwhile, the plan limits processed foods such as refined grains, convenience meals, and sugary drinks.

According to the 21-Day Smoothie Diet creator, the plan provides a total of around 1,500 calories per day.

Consuming 1,500 calories per day will lead to weight loss for many people. However, this may vary based on many different factors, including your age, body size, health status, and activity level (1).

The diet also encourages a variety of nutrient-dense foods, like fruits, vegetables, nuts, and seeds, all of which are high in fiber.

Fiber moves through the digestive tract slowly, helping to keep you feeling fuller for longer, which could support weight loss (2, 3).

However, despite being low in calories and high in fiber, the 21-Day Smoothie is also very restrictive and can be difficult to follow.

Furthermore, research suggests that liquids, such as smoothies, are less filling than solid foods, meaning you may feel more hungry drinking mostly smoothies each day (4).

Not only that, but some studies show that weight loss programs that use meal replacements may be associated with a higher risk of weight regain once a typical diet is resumed (5, 6).

Therefore, while swapping some of your meals for smoothies may lead to short-term weight loss, its unlikely to be effective long-term.

The 21-Day Smoothie Diet is low in calories, plus high in fiber, which may lead to short-term weight loss. However, studies suggests that smoothies may be less filling than solid foods. Additionally, the plan may be difficult to follow and could increase the risk of weight regain.

In addition to being restrictive, unsustainable, and difficult to follow, the 21-Day Smoothie Diet may have several other downsides and side effects.

Eating just one solid meal per day and replacing your remaining two meals with smoothies may increase the risk of nutritional deficiencies.

Though the smoothie recipes recommended by this program contain nutrient-dense ingredients like fruits and veggies, they also omit or limit many of the foods typically included in a balanced meal, such as whole grains, healthy fats, and lean proteins.

Some are also low in protein. For example, the Green Detox smoothie made with kale, coconut water, bananas, ginger, and lemon contains less than 4 grams of protein per serving.

That makes it challenging to ensure youre meeting your protein needs, negatively impacting tissue repair, muscle growth, immune function, and more (7).

Additionally, though the diet claims to provide around 1,500 calories per day, most the smoothie recipes are very low in calories and unlikely to provide enough calories to meet the needs of most healthy adults.

Consuming too few calories each day can slow your metabolism and cause serious negative side effects, including hunger, nausea, headaches, and fatigue (8, 9).

Many of the smoothies on the 21-Day Smoothie Diet contain multiple servings of fruits, including bananas, pineapples, peaches, and strawberries.

Some also contain other high sugar ingredients, such as honey or granola.

Though these ingredients can be enjoyed as part of a healthy, balanced diet, the high amounts included in this diet may not be suitable for everyone.

In particular, people with diabetes may need to monitor their intake of foods high in carbohydrates, such as fruit or honey, to prevent spikes in blood sugar levels (10).

One of the biggest flaws of the 21-Day Smoothie Diet is that there is no research to back it up.

While smoothies can be a great addition to a well-rounded diet, theres no evidence to show that eating smoothies in place of other nutrient-dense foods can improve your skin, gut health, or immune function, as the diet claims.

Furthermore, the diets official website is filled with testimonials from customers claiming to lose large amounts of weight very quickly.

Not only is this unrealistic and unsustainable, but it could also be harmful to health (11).

The 21-Day Smoothie Diet is not based on evidence and may be associated with an increased risk of nutritional deficiencies. It is also relatively high in carbs and sugar.

The 21-Day Smoothie Diet is a 3-week weight loss plan that involves replacing some of your meals each day with smoothies.

Though the diet encourages many nutritious ingredients, its also restrictive, unsustainable, and very low in calories and protein, increasing the risk of nutritional deficiencies and other side effects.

Furthermore, its not backed by research and is high in carbs and sugar, which might not suit people with diabetes.

Instead of cycling through different fad diets to reach your goals, consider pairing a nutritious, well-rounded diet with a healthy lifestyle for best results.

That is more beneficial for weight management and overall health in the long run, and its also much more simple, sustainable, and effective.

Original post:
Smoothie diet: Benefits, Weight Loss, and Downsides - Healthline

More Americans want to lose weight for the sake of their health rather than forappearance, according to a new study. This may be one of the fewpositive legacies of COVID, since prioritizing health is a way to be more motivated and consistent which helps dieters achieve long-term results,according to a new poll released by the Mayo Clinic Diet.

That's good news becauselifestyle changes are the only known way to effectively keep off the weight once the dieter manages to lose it, studies have shown. So even if you, like most others, have gone on multiple diets in your lifetime, chances are you've gained the weight back once you "go off" the diet.

This study found that the typical dieter has tried to lose weight on a diet six or more times in theirlifetime, and they are "constantly thinking about losing weight" yet finding it a challenge. Fad diets like keto don't work and can raise your risk of heart disease in the long run.

What works for weight loss? Lifestyle changes are the best approach to lasting and sustainable weight loss,such as trying the Mayo Clinic Diet, or adopting a mostly plant-based diet high in fruits, vegetables, legumes, whole grains, and nuts and seeds while avoiding animal products such as meat and dairythat are laden with saturated fat.

For a two-week plant-based diet with four recipes a day and expert tips, created by a plant-based RD, try The Beet's 2 Week Plant-Based Diet Plan and lose weight the healthy, sustainable way.

Theinsights are part of the key findingsof a comprehensive Diet Mindset Assessment study that asked a large swath of the public: Why are you trying to lose weight? The Mayo Clinic Healthy Living Center partnered withDigital Wellness to conduct the survey.

The doctors and researchers at Mayo also report back on what actually works for long-term sustainable weight loss, and it is a motivation that is sustainable, not just to look hot in a new dress, in contrast to the diet that Kim Kardashian used to lose 16 pounds to fit into the dress Marylin Monroe wore to sing Happy Birthday to President John F. Kennedy.

When it comes to dieting, health is now a key motivator: 83 percent of respondents said they valued health above all other aspirations. For most Americans, weight is a health issue. With over one-thirdof Americans living with obesity (defined as a BMI of over 30 percent) and another third being clinically overweight, many consumers have been told by their doctors that in order to be their healthiest, losing weight is a priority.

For the other percentage of dieters, trimming down or losing more than a small amount of weight can be motivated by health and fitness goals as well as appearance, the Mayo Clinic and Digital Health survey found.

Obesity is a disease that is on the rise in the U.S. and makes someone more susceptible to other diseases such as certain types of cancer, type 2 diabetes, heart disease, and stroke. The percentage of Americans that are obese has significantly increasedin a generation.

Right now in America, over two-thirds of the adult population is considered dangerously overweight, with 36.9 percent of American adults age 20 and older being obese, which is twice as many as three decades ago. Approximately 15 percent of children and teens are overweight, three times as many as there were in the 1980s.

For an interactive chart of obesity by state, check out this story and find your state.

In a related health problem, some 88 million adults have what is called "pre-diabetes" which is a symptomless condition that makes it hard to lose weight, yet vital that we try for the sake of our health.

Health surpassed physical appearance as an aspiration by over five times for those surveyed, consistent with a separate finding that post-COVID, Americans are currently more intrinsically motivated to maintain a healthy weight. Previously those dieters might have been more motivated by "external" factors such as appearance and status.

Over 55 percent of participants in the survey had dieted at least six times during their lifetime, indicating that Americans are seeking a sustainable and sensible solution to healthy weight management.

Its rather a unique study because of its large scale and that it explores the psychology of a dieters mindset, said Donald D. Hensrud, MD, MS, Medical Director of the Mayo Clinic Healthy Living Program. We wanted to learn more about the motivations and aspirations around weight loss, and if a stage ofreadiness or sense of identity played a role in a diet program's results.

Most of the dieters in the survey had a health goal as a motivator for losing weight.Of the total of 209,269 people who answered the mindset questionnaire, the majority had a BMI that would be considered obese: Theaverage BMI of people who completed the quiz was 32.3. Of the total, 30 percent were classified as overweight and 56 percent as obese.

Among the respondents, 40 percent had dieted one to 5 times in their lifetime and 22 percent had dieted 6 to 10 times. The vast majority (86 percent) were female. They aged between 31-70 years with an average age of 52 years.

The study indicates that people are ready for a lifestyle change for good reasons: to improve their health. Thats good news, said Hensrud. It means a lifestyle changing diet, like the New Mayo Clinic Diet, will be a good fit for them and is likely to have positive results that will last a lifetime.

A plant-based diet has been shown to be more effectivethan keto and other dietsto achieve long-term, sustainable, healthy weight loss. Studies show that people who give up red meat and full-fat dairy and substitute animal-based proteins in favor of plant-based sources have a lower risk of heart disease, type 2 diabetes, and certain cancers, and also a lower risk of dying from all causes.

For more on how to lose weight on a plant-based diet, visit The Beet's Diet & Weightloss stories and try the 2 Week Plant-Based Diet Plan with 4 recipes and expert tips a day.

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New Data Reveals the Most Effective Motivation for Losing Weigh - The Beet

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