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Intermittent fasting is a method of dieting which prioritizes when you eat as opposed to what youre eating. Fasting windows can vary in length, but the most commonly followed variation is 16 hours fasted and 8 hours of eating. While IF doesnt follow the typical food restricting definition of a diet, limiting your eating time will naturally reduce your food intake, putting you in a calorie deficit for weight loss.

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Research is still being conducted as to the long term benefits of intermittent fasting, but some studies have already shown that fasting has the capability to delay aging and prevent the onset of some diseases.

Allie McCormick turned to intermittent fasting on a whim, and couldnt be happier with her results and the lifestyle shift that followed.

As told by Allie McCormick to Merrell Readman.

via Allie McCormick

I stumbled upon intermittent fasting through a forum on Reddit and thought it was weird, but I saw people getting good results. I'd heard "breakfast is the most important meal of the day," and thought that people were nuts for starving themselves. But, as I grew tired of gaining and losing the same weight over and over, I finally decided to give it a try.

via Allie McCormick

I lost 10 pounds my first month without counting calories, exercising regularly, or "dieting. I just ate all my food between 12pm and 8pm every day. Since I started my intermittent fasting journey, I've lost nearly 50 pounds and have been able to keep it off. Now I help others with fasting too.

via Allie McCormick

The first change I noticed is that I was really hungry in the beginning, but by the end of the first week I was forgetting to eat! Fasting helps with overall hunger and cravings. I also noticed that if I drank lots of water, the weight came off much more quickly. As I got into fasting, I wound up growing more motivated to eat cleaner and exercise the healthier I got as well. Now, I focus on eating more plant-based foods and get 10,000 steps a day.

Intermittent fasting gives you that initial push you need to change your life because it instills a sense of self-control and "Yes, I can do this."

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I Tried Intermittent Fasting For Weight LossHere Are The Before And After Photos - SheFinds

Although Pete Davidson might be sacrificing his body art for the sake of his acting career, removing his tattoos may be pertinent for his health. As Davidson's fans flocked to Mike McGranaghan's tweet, one user took to the replies to suggest why the comedian might want to forgo his tattoos. "There have been tons of articles, starting with Newsweek, about the toxic ingredients in tattoos and the fact that they can migrate into your bloodstream. Given Pete's medical issues with Crohn's, this was a wise decision long-term," they wrote to the film critic on Dec. 16, 2020.

Although there is no confirmation that this is the case, Davidson has openly discussed his struggles with Crohn's Disease, which is "an inflammatory bowel disease (IBD). It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition," according to the Mayo Clinic. When talking with Howard Stern in 2018, Davidson revealed that smoking marijuana is necessary for him to deal with his diagnosis. "I have Crohn's disease, so it helps more than you can imagine," Davidson said at the time, according toHigh Times. "There was a point where I couldn't get out of bed (due to the pain). I was 110 pounds. I also just love smoking weed. I've been smoking weed every day for eight years."

Only time will tell whether Davidson wipes himself clean of the tats. Stay tuned!

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Why Pete Davidson might be removing all of his tattoos - Nicki Swift

David E. Rattray

Lately, I have had a number of patients refer sardonically to their Covid 15, a play of words on the colloquial weight gain that many college freshmen experience their first year at college. The effects of this pandemic are myriad and will be years in the delineating, but among them is definitely some degree of physical deconditioning for many people, myself among them.

Just last week, a patient bemoaned the 10 pounds or so they had gained this year and asked my advice about where to start in terms of reversing the trend. As I shifted in my chair and thought about the uncomfortably tight nature of my dress pants, I did my best to communicate the following.

First, if you find yourself among those of us who have gained a few pounds this year, dont be too hard on yourself. Given such widespread disruptions to our routines, its certainly not surprising to see people exercising less and eating more. Gyms are closed, group exercise routines are curtailed, and the comfort of a bag of chips at midnight after a long shift or an extra muffin with breakfast to offset the isolation are all understandable.

These choices do not make you a bad person. (Im writing this because Im reminding myself of the same thing.) I have been fortunate to lose about 50 pounds over the past six years through dietary changes and exercise, and the fact that Ive gained five of those back during this pandemic makes me feel like a failure. It is vital, though, for me to remember that stressful eating is simply a pattern of behavior. And behaviors can be changed.

So what can you do if you find yourself in the same shoes?

First, I recommend keeping a food diary. For a week or two, write down everything you eat, and I do mean everything. Get a concrete idea of what your habits are so that you can identify the most unhealthy ones and/or the ones you most want to change.

Then, remember that study after study has shown that successful weight loss comes down to creating a caloric deficit. Yes, certain diets and challenges like the Keto or Whole30 diets can accentuate those deficits or make them easier to attain, but it still comes down to taking in less than you expend. A food diary can help you identify some key high-caloric players in your diet, such as late-night ice cream or daily sodas.

Start with these. At the same time, try to add a few more fresh vegetables in with your meals or for snacks. Dont try to build Rome overnight, but do start working on the foundation. I also often recommend giving yourself at least 12 straight hours a day where you arent eating. This may help decrease insulin resistance given what some studies on intermittent fasting have shown and, equally important in my opinion, it also cuts down on late night snacking.

Then, give yourself time and space to see what happens. Dont get discouraged if its a slow process. Nutritional science has also shown that successful weight loss (if by successful, we mean weight loss that stays off in the long term) happens gradually, often around a half a pound to a pound per week. Give yourself that time, and do your best to remember that the goal is movement in the right direction, not speed.

If you are someone who needs a framework, consider looking over something like the Mediterranean diet, which has quite a bit of evidence to support it as a heart-healthy approach to eating. You should also, of course, ask your doctor if there are specific things you need to keep in mind or aim for given your own medical history. A diabetic patient, for example, should be mindful and careful about going extended periods of time without eating so as to avoid dangerously low dips in blood sugar.

Obviously, these are just baby steps on what can be an incredibly complicated and individual journey. For many people, myself included, just the topics of weight loss and body image provoke a tsunami of emotional responses, not the least of which have to do with how the medical profession has struggled to de-emphasize fat-shaming and instead promote both body positivity and healthy behaviors. I dont pretend to have all of the answers, but these are some of the approaches that have worked for my patients and me, and hopefully they will do the same for you.

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On Call: Reversing the Covid 15 - East Hampton Star

There has been a weight loss surge and 570 NHS patients have received bariatric surgery to lose weight, and 62 of those are under 18.

It costs the NHS between 5,000 and 13,000 per person. And obesity costs the NHS 5.1 billion a year.

Gastric band surgery is only offered to someone with a body mass index of over 40.

So someone, say, 5ft10ins and around 20 stone.

But NICE now recommend to change the criteria so more people are eligible.

Approximately 40 per cent of NHS patients who are morbidly obese will have diabetes and being obese will result in a premature life span, said a bariatric surgeon on the news.

More than 10 per cent of all NHS drug spending is now devoted to diabetes, which have sparked warnings that obesity could bankrupt the health service.

Type 2 diabetes long term is as dangerous as Type 1 as it is progressive and furs up all the major arteries, increasing the risk of limb amputations, kidney failure, blindness, cardiovascular disease.

Professor Dame Sally Davies blames the countrys high death toll on a structural environment that enabled junk food makers to encourage consumption.

The UK has one of the highest obesity rates in the world and the second highest in Europe, with nearly one in three adults obese.

Obesity, defined as a body mass index greater than 30, raises the risk of dying of Covid-19 by 48 per cent.

If nothing changes, more than five million people will have diabetes in the UK by 2025.

Around 90 per cent of people with diabetes have Type 2 diabetes.

Around eight per cent of people with diabetes have Type 1 diabetes.

People really need to be more responsible for their own health, not only to save the NHS billions but for their own sake.

There are currently several thousand people claiming Disability Living Allowance being morbidly obese, all funded by the taxpayers.

Tony Henshaw

Arddleen

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LETTER - Tax payers are footing the bill of obesity - Powys County Times

Protein is an essential nutrient for regulating cell function, building tissue, and helping your blood carry oxygen throughout the body. However, it's possible to eat too much protein which can overload your liver and kidneys and cause some other minor side effects like bad breath and appetite loss.

Not getting enough protein can lead to fatigue, brain fog, hunger, and slower recovery from illness and injury. It can also cause loss of muscle mass, particularly in the elderly.

On the other hand, it's possible to experience side effects from getting too much protein, particularly if you have kidney problems.

It's important to know which sources of protein are better than others for avoiding health risks. What's more, there are ways to gauge if you're getting the right amount of protein, how to tell if you're getting too much, and when to see a doctor.

In general, a person should get at least 0.36 grams of protein per pound of body weight per day. However, protein needs will vary depending on factors including age, lifestyle, and gender:

For example, a moderately active adult woman who works out for 2-3 hours a week and weighs 130 pounds would need between 70 to 118 grams of protein a day for health.

Eating too much protein isn't a problem for most people, but if you do consistently overdo it for long periods of time, it can eventually overload your digestive system, liver, and kidneys leading to problems like:

How much protein is too much? If more than 35% of your daily calories are coming from protein, that's when it's time to reconsider your diet.

Research suggests that it's safe to eat as much as 1 gram of protein per pound of body weight per day in the long term. And certain people (including athletes) can safely consume up to 1.6 grams per pound per day. That's equal to up to 35% of daily calories from protein, or as much as 219 grams of protein per day on a 2,500 calorie diet.

For most people who are otherwise healthy, too much protein isn't likely to be an issue.

"Your body will use what it needs for structural maintenance and tissue turnover, and the rest can be burned for energy," registered dietitian and sports nutritionist Georgie Fear told Insider.

All protein is broken down into amino acids. If you eat more than you can use, your body can't store the extra, so it's processed and ultimately excreted in your urine, says Fear. Extra calories from protein, though, can be stored as fat if not used.

Most people consume well within the recommended range for protein intake, according to Allison Knott, a registered dietitian based in Brooklyn, New York.

"On average, most people aren't coming close to the upper end of the protein range of 35%," she told Insider.

More than that, however, can cause problems like dehydration, fatigue, headaches, digestive distress, and even seizures, from overloading the digestive system, liver, and kidneys.

In particular, people with kidney problems should avoid excess protein, since it can cause extra stress on the kidneys by forcing them to break down and filter out whatever your body can't use. Research has also linked excess protein intake to higher risk of kidney stones in people with a family history of renal disease or who get most of their protein from animal sources.

Most people don't have to worry about serious health risks from eating too much protein, but you may experience minor side effects:

Bad breath: Excess protein can sometimes cause bad breath, due to bacteria breaking down the protein and emitting odors that can smell like cabbage or rotten eggs.

GI issues: Eating too many protein-rich foods may also mean you're missing out on other essential nutrients like fiber, since protein-rich animal products don't contain fiber. A low-fiber diet can cause digestive issues ranging from constipation, diarrhea, mild nausea, or fatigue after meals. It can also change your microbiome, the colony of beneficial bacteria and microorganisms that live in your gut.

Loss of appetite: Eating a lot of protein can also decrease appetite, says Fear, since it keeps you feeling full for longer. That can make it useful for weight-loss goals.

Weight gain: However, eating too much of anything can still lead to weight gain, so if you're consuming too many calories in the form of protein, those excess calories will be stored as fat and lead to weight gain.

Eating too much protein can lead to harmful side effects if you have existing kidney problems, or a family history of renal disease or kidney stones.

Some symptoms can indicate possible kidney disease or failure, a serious and potentially dangerous health problem, according to the National Kidney Foundation.

See a doctor if you experience some combination of the following symptoms of kidney problems:

"There are no 'bad' protein sources, but keep an eye on the saturated fat and calorie content of your protein sources to optimize heart health," Fear said.

Protein sources like fatty meats and some processed foods are associated with an increased risk of cancer, diabetes, and heart disease, according to the Harvard T.H. Chan School of Public Health.

In addition, be wary of protein supplements, including bars and shakes, as they can contain a lot of additives. Some brands have more than 20 grams of sugar per serving (as much as a scoop of ice cream) or contain artificial sweeteners that may be just as bad for your health in the long term.

If you do decide to supplement, find a brand you trust, read the label and ingredient list carefully, stick to the recommended serving size, and use in moderation.

There's no ideal time to eat protein, so long as you get enough, experts say, but spreading your intake out throughout the day can be helpful.

"Balancing protein in meals throughout the day has shown to be beneficial for muscle protein synthesis and maintenance of lean body mass," Knott said.

Protein is an important nutrient for health and most people don't have to worry about getting too much. However, you should aim for healthier sources of protein such as lean meats and whole plant foods to avoid higher risk of chronic diseases. People with kidney issues should monitor protein intake carefully, since too much could cause serious health problems.

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What happens when you eat too much protein, and how much is healthy - Insider - INSIDER

DUBLIN, Dec. 9, 2020 /PRNewswire/ -- The "Global Intragastric Balloon Market 2019-2028" report has been added to ResearchAndMarkets.com's offering.

The global intragastric balloon market is predicted to grow at a CAGR of 12.33% during the forecasting period 2019-2028.

Intragastric ballooning is a procedure that requires no stitches and incisions. The entire process of placement of the balloon takes nearly 20 minutes and the patient can be discharged within two hours after the insertion. The recovery time is also very short, which has resulted in the rising adoption of intragastric balloon implantation. It is estimated that one-third of the total population of the world has excess weight, due to rapid urbanization, unhealthy diets and less physical activity.

The government across the world is implementing several initiatives to reduce the obesity rate by making huge investments towards R&D. However, short-term effects associated with the instragastric ballooning is impeding the global market growth. Besides, it is not a permanent weight loss treatment, and hence, the patients are required to maintain a proper lifestyle for long-term weight loss. Stomach ulcers are also another side-effect of this procedure.

REGIONAL OUTLOOK

The global market report covers the countries from North America, Europe, the Asia-Pacific, Latin America and the Middle East and Africa.

The Asia-Pacific market is expected to display the fastest growth in the global intragastric balloon market over the forecasted period. Due to the rapid changes in the living pattern of people, unhealthy diets and sedentary lifestyles, there is a high prevalence of obesity in the region. The majority of the obese population is subsequently affected by diabetes, hypertension, stroke and heart diseases. Therefore, there is an increasing need for weight loss procedures like instragastric balloon implantation. These factors are anticipated to push the growth of the market in the Asia-Pacific region over the upcoming years.

COMPETITIVE OUTLOOK

The major companies in the intragastric balloon market are Endalis, Silimed (Sientra Inc), Apollo Endosurgery Inc, BAROnova, Allurion Technologies Inc, Aspire Bariatrics, Obalon Therapeutics, ReShape Lifesciences Inc, Spatz FGIA Inc, Allergan (AbbVie), Helioscopie, MedSil, Districlass Medical and Medtronic

Allergan (AbbVie) is a global company specialized in the development, manufacturing, and marketing of medical aesthetics, pharmaceutical products, biosimilars, and OTC (over-the-counter) pharmaceutical products.

Besides, it offers products for medical aesthetics & dermatology, eye care, women's health, gastroenterology and urology. The BIB/Orbera intragastric balloon is a device provided by the company that lets endoscopist to insert the balloon inside the stomach via the mouth or esophagus. Allergan is headquartered in Dublin, Ireland, and operates in the US, Europe, Asia, among other regions of the world.

Key Topics Covered:

1. Global Intragastric Balloon Market - Summary

2. Industry Outlook2.1. Market Definition2.2. Evolution and Transition of Intragastric Balloons2.3. Porter's Five Forces Model2.4. Covid-19 and Its Impact on Intragastric Balloon Market2.5. Industry Components2.6. Supply Chain Outlook2.7. Market Attractiveness Index2.8. Vendor Scorecard2.9. Key Insight2.10. Market Drivers2.10.1. Short Duration of Hospital Stay and Recovery Time2.10.2. Rising Obesity Worldwide2.11. Market Restraints2.11.1. Short-Term Effects Associated With Intragastric Ballooning2.11.2. Reimbursement Issue2.12. Market Opportunities2.12.1. Rise in the Government Initiatives Regarding Obesity2.12.2. Concerns Associated With Morbid Lifestyle2.13. Market Challenges2.13.1. Stringent Product Approval Procedure

3. Intragastric Balloon Market Outlook - by Component3.1. Single Balloon3.2. Dual Balloon3.3. Triple Balloon

4. Intragastric Balloon Market Outlook - by Filling Material4.1. Saline-Filled4.2. Gas-Filled

5. Intragastric Balloon Market Outlook - by Industry Verticals5.1. Clinics5.2. Hospitals5.3. Ambulatory Surgical Centers

6. Intragastric Balloon Market Outlook - by Region

7. Company Profile7.1. Allurion Technologies Inc7.2. Medsil7.3. Allergan Inc (Abbvie)7.4. Obalon Therapeutics Inc7.5. Apollo Endosurgery Inc7.6. Reshape Lifesciences7.7. Aspire Bariatrics Inc7.8. Baronova Inc7.9. Districlass Medical7.10. Endalis7.11. Medtronic plc7.12. Silimed Inc (Sientra)7.13. Helioscopie Sa7.14. Spatz Fgia

For more information about this report visit https://www.researchandmarkets.com/r/ysxmwt

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets Laura Wood, Senior Manager [emailprotected]

For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

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SOURCE Research and Markets

http://www.researchandmarkets.com

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Global Intragastric Balloon Market Report 2020: Short Recovery Time has Resulted in the Rising Adoption of Intragastric Balloon Implantation -...

PLAINSBORO, N.J., Dec. 4, 2020 /PRNewswire/ --Novo Nordisk today announced that the U.S. Food and Drug Administration (FDA) approved an updated label for Saxenda(liraglutide) injection 3 mg for use in the treatment of obesity in adolescents (1217 years) with a body weight above 60 kg and an initial body mass index (BMI) corresponding to 30 kg/m2 or greater for adults, as an adjunct to reduced-calorie meals and increased physical activity. Saxenda was approved in 2014 for chronic weight management in adults with a BMI 30 kg/m2, or 27 kg/m2 with at least one weight-related comorbidity, as an adjunct to a reduced calorie meal plan and increased physical activity.1

Over the last 20 years, the global prevalence of children and adolescents with excess weight has doubled from 1 in 10 to 1 in 5.2Research also shows that when both parents have excess weight, 80% of their children will have obesity.3However, current treatment options for this population are limited, highlighting a considerable and growing need for additional treatment strategies.4

"New options to treat adolescents who live with obesity can bring much-needed hope to families and help address this growing epidemic," said Dr. Aaron Kelly, Professor of Pediatrics and co-director of the Center for Pediatric Obesity Medicine at the University of Minnesota. "With up to 90 percent of adolescents with obesity likely to have it as adults and thus at increased risk for developing weight-related complications, it's important to address weight care and offer support early on.3,5I'm encouraged that healthcare providers now have another tool in developing a personalized, complete care plan to help adolescents lose weight and keep it off."

The safety and efficacy of Saxenda as a treatment for adolescents with obesity is supported by data from a phase 3a trial published earlier this year in the New England Journal of Medicine. The 56-week clinical trial investigated the effects of Saxenda compared to placebo for weight management in 251 patients aged 12-17 living with obesity as an adjunct to lifestyle therapy, defined as counselling in healthy nutrition and physical activity for weight loss. In the trial, the primary endpoint was change from baseline in Body Mass Index (BMI) Standard Deviation Score (SDS) at week 56.6

The data demonstrated a significant reduction in BMI-SDS, as well as reductions in BMI, mean body weight, and other weight-related endpoints vs. placebo in adolescents with obesity when using Saxenda as an adjunct to lifestyle therapy. Adverse events seen in an adolescent population were similar to those observed in adults. The most common adverse reactions were gastrointestinal events, including nausea, vomiting and diarrhea.6

"The rise in adolescent obesity is contributing to a public health crisis, and it poses a real challenge for healthcare professionals due to the limited treatment options available," said Mads Krogsgaard Thomsen, executive vice president and chief scientific officer of Novo Nordisk. "We are proud to be able to offer a new treatment option for adolescents with obesity and their families in the US, as the FDA approval marks another significant milestone for Saxenda."

What is Saxenda?

Saxenda (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight (BMI 27) who also have weight-related medical problems or obesity (BMI 30), and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight off. Saxenda should be used with a reduced calorie diet and increased physical activity.

Important Safety Information

Do not share your Saxenda pen with others even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

What is the most important information I should know about Saxenda?Serious side effects may happen in people who take Saxenda, including:

Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Saxenda and medicines that work like Saxenda caused thyroid tumors, including thyroid cancer. It is not known if Saxenda will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Do not use Saxenda if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN2).

Who should not use Saxenda?Do not use Saxenda if:

Before taking Saxenda, tell your health care provider about all of your medical conditions, including if you:

Tell your health care provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. Saxenda slows stomach emptying and can affect medicines that need to pass through the stomach quickly. Saxenda may affect the way some medicines work and some other medicines may affect the way Saxenda works. Tell your health care provider if you take diabetes medicines, especially insulin and sulfonylurea medicines.

How should I use Saxenda?

What are the possible side effects of Saxenda?Saxenda may cause serious side effects, including:

The most common side effects of Saxenda in adults include nausea, diarrhea, constipation, vomiting, injection site reaction, low blood sugar (hypoglycemia), headache, tiredness (fatigue), dizziness, stomach pain, and change in enzyme (lipase) levels in your blood. Additional common side effects in children are fever and gastroenteritis.

Please see Prescribing Information and Medication Guide for Saxenda at http://www.novo-pi.com/saxenda.pdf.

About the phase 3 trial (NCT02918279)

The trial investigated the effect of Saxenda (liraglutide 3.0 mg or maximum tolerated dose) compared to placebo for weight management in 251 adolescents (aged 12 to <18 years) living with obesity as an adjunct to lifestyle therapy.6 The trial included a 12-week run-in period of lifestyle therapy, a 56-week treatment period (including dose escalation over 4 to 8 weeks) on Saxenda or placebo and a 26-week follow-up period without Saxenda or placebo.6 All participants received lifestyle therapy beginning with the run-in period and during the 56-week treatment period and 26-week follow-up period.6 The phase 3a trial was a post-marketing requirement of the FDA under the Pediatric Research Equity Act (PREA), which aims to ensure treatments are safe and effective for children and adolescents.7,8

About SaxendaSaxenda (liraglutide) injection 3.0 mg is a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist with 97% similarity to naturally occurring human GLP-1, a hormone that is involved in appetite regulation and food intake.1 Like human GLP-1, Saxenda is believed to work in areas of the brain involved in appetite regulation, including the hypothalamus.1Saxenda for use in adults with obesity was evaluated in the SCALE (Satiety and Clinical Adiposity Liraglutide Evidence) clinical trial program. Since launch in 2015, more than 1.5 million patients have been treated with Saxenda globally.7

Saxenda is already indicated in the US for chronic weight management in adults with a BMI 30 kg/m2, or 27 kg/m2with one or more weight-related comorbidities, as an adjunct to a reduced-calorie meal plan and increased physical activity.1

About obesityObesity is a chronic, progressive and misunderstood disease that requires long-term medical management.9,10 One key misunderstanding is that this is a disease of willpower, when in fact there is underlying biology that prevents people from achieving long-term weight loss.11 Obesity is influenced by a variety of factors, including genetics, appetite signals, behavior and the environment.11 It is a gateway disease and is associated with at least 60 other health conditions.12 The current COVID-19 pandemic has highlighted that obesity also increases the risk for severe illness and hospitalization due to COVID-19.13,14In the United States, more than 42% of adults live with obesity.15

About adolescent obesityAdolescents with obesity are also more likely to develop weight-related diseases, like diabetes and cardiovascular diseases, at a younger age.16Just like other chronic diseases, obesity requires long-term management.9,10 Research shows that when both parents have excess weight, about 80% of their children will have obesity.3 Globally, more than 124 million children and adolescents have obesity.17In the United States, nearly 1 in 5, or about 13.7 million, children and adolescents have obesity.18,19

About Novo Nordisk Novo Nordisk is a global healthcare company that's been making innovative medicines to help people with diabetes lead longer, healthier lives for 95 years. This heritage has given us experience and capabilities that also enable us to help people defeat other serious diseases including obesity, hemophilia and growth disorders. We remain steadfast in our conviction that the formula for lasting success is to stay focused, think long-term and do business in a financially, socially and environmentally responsible way. With U.S. headquarters in New Jersey and production and research facilities in six states, Novo Nordisk employs nearly 6,000 people throughout the country. For more information, visitnovonordisk.us, Facebook, Instagramand Twitter.

References

1US Food and Drug Administration (FDA). Saxenda Prescribing Information. December 2020.

2UNICEF. The state of the world's children 2019. Available at: https://www.unicef.org/media/60806/file/SOWC-2019.pdf. Last accessed: November 2020.

3Lifshitz F. Obesity in Children. J Clin Res Pediatr Endocrinol.2008 Dec; 1(2): 5360

4Cardel M, Jastreboff A, Kelly A. Treatment of Adolescent Obesity in 2020. JAMA. 2019; 322:17071708.

5Gordon-Larsen P, The NS, Adair LS. Longitudinal Trends in Obesity in the United States from Adolescence to the Third Decade of Life. Obesity. 2010; 18 (9): 1801-1804

6Kelly A, Auerbach P, Barrientos-Perez M. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1916038. NEJM. 2020;DOI: 10.1056/NEJMoa1916038

7Novo Nordisk. Data on File.

8Center for Drug Evaluation and Research. Pediatric Research Equity Act. U.S. Food and Drug Administration. https://www.fda.gov/drugs/development-resources/pediatricresearch-equity-act-prea. Last accessed: November 2020.

9American Medical Association. A.M.A Adopts New Policies on Second Day of Voting at Annual Meeting. Obesity as a Disease. Available at: http://news.cision.com/american-medical-association/r/ama-adopts-new-policies-on-second-day-of-voting-at-annual-meeting,c9430649. Last accessed: November 2020.

10Bray GA, Kim KK, Wilding JPH. World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. ObesRev. 2017;18(7):715-723. doi:10.1111/obr.12551.

11Wright SM, Aronne LJ. Causes of obesity. Abdom Imaging. 2012;37(5):730-732.

12Bays HE, McCarthy W, Christensen S, et al. Obesity Algorithm, presented by the Obesity Medicine Association. Available at: https://obesitymedicine.org/obesity-algorithm/. Last Accessed: November 2020.

13Finer N, Garnett SP and Bruun JM. COVID-19 and obesity. Clin Obes. 2020; 10:e12365.

14Ryan DH, Ravussin E and Heymsfield S. COVID 19 and the Patient with Obesity - The Editors Speak Out. Obesity. 2020; 28:847.

15Centers for Disease Control and Prevention. Adult Obesity Facts. Available at: https://www.cdc.gov/obesity/data/adult.html. Updated June 29, 2020. Last accessed: November 2020.

16World Health Organization. Childhood overweight and obesity. Available at: https://www.who.int/dietphysicalactivity/childhood/en/. Last accessed: November 2020.

17World Health Organization. Obesity and overweight. Available at: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Last accessed: November 2020.

18Centers for Disease Control and Prevention. Childhood Overweight and Obesity. Available at: https://www.cdc.gov/obesity/childhood/index.html. Updated September 11, 2018. Last accessed: November 2020.

19Centers for Disease Control and Prevention. Childhood Obesity Facts. Available at: https://www.cdc.gov/obesity/data/childhood.html. Updated June 24, 2019. Last accessed: November 2020.

SOURCE Novo Nordisk

http://www.novonordisk-us.com

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FDA approves Saxenda for the treatment of obesity in adolescents aged 12-17 - PRNewswire

Dr. Brian Kelly

By Dr. Brian Kelly

In the United States, 30 million adults ages 18 and older are living with diabetes and 84 million contend with prediabetes. And the numbers are growing. That makes this an important public health problem. As such, there are suitable screening tests, which are important as an early asymptomatic stage exists. Early treatment during the asymptomatic stage improves the long-term outcome.

Diabetes is actually a vascular disease that causes buildup of plaque in the blood vessels which is known as atherosclerosis. This process is caused by irritation and inflammation in the vascular beds (or blood vessel systems). This can result in heart attack, stroke or infection/inflammation of the lower extremities due to plaquing in the small arteries of the lower legs, depending on which vascular bed is affected. It also causes retinopathy, which is a disease of the eyes due to clogged blood vessels in the retina as well as neuropathy due to problems with the blood vessels involved with nerves.

In light of the relatively long asymptomatic period that exists, screening tests are very important. These tests include glycated hemoglobin (hemoglobin A1 C) which is a buildup of glucose on the red blood cell. We can also use fasting glucose and the oral glucose tolerance test (OGTT) which is a two-hour test following administration of 75 grams of sugar water. These tests are all available at Powell Valley Healthcare. Early identification of diabetes allows interventions to prevent or limit cardiovascular disease.

Other factors which may amplify the risk of diabetes mellitus include family history of diabetes as well as hypertension and high cholesterol. There are scoring systems for risk factor assessment that have been established by the CDC and the American Diabetes Association.

Lifestyle intervention programs aimed at weight loss and increased activity levels, and medications such as metformin, reduce the risk of type 2 diabetes in high risk individuals. Here at PVHC we have providers who can screen for diabetes as well as treat diabetes and we have diabetes education, which is very important to prevent the complications associated with the disease.

Our diabetes educators are hosting their second Prevent T2 program beginning in March 2021. If you have prediabetes, this program can help you reverse the full onset of diabetes and ultimately prevent cardiovascular health problems in the future.

For more information on the Prevent T2 program, please call Tina Braet-Thomas at 307-754-2267, extension 3604.

(Dr. Brian Kelly is a cardiologist at Powell Valley Healthcare.)

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Healthy heart: Diabetes and cardiovascular diseases - Powell Tribune

You may be used to drizzling honey over oatmeal or in your tea. However, the trend today is to slather it on your face. Really.

People are searching for ways to use honey for face wash, and you can find how-to videos for honey face masks on TikTok and Instagram.

It may seem odd at first. You may be wondering why you would put something super sticky and full of sugar on your skin. Wouldnt that lead to breakouts (and a mess in your bathroom)?

Well, according to some, using honey on your face may lead to smooth, moisturized, blemish-free skin.

We dove into the research and talked to expert dermatologists to find out: Should everyone start using honey for face wash?

Whether its a tried-and-true skin care regimen, how often you wash your hair, or the cosmetics youre curious about, beauty is personal.

Thats why we rely on a diverse group of writers, educators, and other experts to share their tips on everything from the way product application varies to the best sheet mask for your individual needs.

We only recommend something we genuinely love, so if you see a shop link to a specific product or brand, know that its been thoroughly researched by our team.

Using honey as face wash isnt something beauty bloggers invented. People have used honey for its skin benefits for ages.

Legend has it, Cleopatra used a mask made of milk and honey on her face. Indigenous tribes in Burkina Faso also use honey to clean their skin.

Many other cultures use honey topically to treat wounds, eczema, and other skin conditions. This includes Ayurvedic medicine, Persian traditional medicine and Quranic medicine.

All of these people were and are on to something. Honey has many powerful properties, says New York City-based cosmetic dermatologist Michele Green, MD. According to research, honey has antibacterial, anti-inflammatory and humectant (moisturizing) properties.

The antibacterial properties make it good as both treatment and prevention for acne, Green explains. This is credited to the hydrogen peroxide in honey, although the amount varies among honey types.

Honeys anti-inflammatory powers come from antioxidants that help calm irritated skin, says Konstantin Vasyukevich, MD, a facial plastic surgeon and rejuvenation expert based in New York City.

And since honey has humectant effects, it may help keep skin looking younger, or at least smoother.

Lastly, honey contains natural enzymes that help remove dead skin cells and reduce redness, Green says.

Its important to note that most cosmetic products contain only up to 10 percent honey.

That doesnt seem like much, but it may still have an effect. As a natural remedy, honey is certainly not as effective in the treatment of medical skin conditions as a prescription medicine would be. However, it can be an effective remedy for someone with a mild skin condition or as a preventative treatment, Vasyukevich says.

It is generally safe to use honey on your skin, since it is great for people with acne [or] eczema. It is even safe for patients with sensitive skin, Green says.

However, consider testing the honey or product on a small area of your skin before applying it all over your face.

If you notice any redness, itching, or swelling when testing it, wash the honey or product off with soap and water. Then, Green recommends applying a topical hydrocortisone cream. Do not continue using the honey or product.

You may be having an irritant or allergic reaction to the honey itself or another ingredient. Consider contacting the manufacturer of the product to learn exactly what it contains. This can help you identify the culprit.

If you are curious about using honey on your face, you have options. Some users swear by applying raw honey directly to their skin and letting it sit for 510 minutes before washing it off.

Others prefer to create a face mask by mixing the honey with other ingredients, such as yogurt, matcha tea powder, or oats. Green shares this honey face mask recipe:

Finally, you can find a variety of skin care products (such as those below) that contain honey. The concentration of honey in these may be very low. So, it may be hard to tell if any benefits you experience are due to the honey or other ingredients.

If you wish to DIY your skin care, keep in mind that each variety of honey has different levels of antioxidants and other beneficial compounds. So, you may see different results depending on which honey youre using.

That said, many recommend Manuka honey, which has been shown to have higher antibacterial activity compared to other types of honey. Many brands add cane sugar or corn syrup to their honey. In a 2018 study of 118 honey samples, 27 percent were of questionable authenticity.

Consider buying local honey. Or use the True Source Honey tool to look up the UPC of a product and verify if its certified as pure.

Not interested in a DIY project? Consider these skin care products that contain honey. Each has at least a 4.5-star rating on Amazon.

Price: $

Appropriate for use on your face, chest, neck, and hands, this moisturizer with Manuka honey and beeswax is super silky not sticky. Its made to absorb well without leaving you greasy.

Buy the LOreal Age Perfect Hydra-Nutrition All-Over Honey Balm online.

Price: $

Peanuts and honey arent only good ingredients for making a sandwich. The two pack antioxidants and moisturizing benefits into this lotion.

Buy the Mario Badescu Honey Moisturizer online.

Price: $$

The charcoal in this mask is said to help relieve clogged pores while the honey moisturizes. The formula contains no parabens, phthalates, sodium lauryl sulfate, propylene glycol, mineral oil, DEA, petrolatum, paraffin, polyethylene beads, or formaldehyde.

Buy the Origins Clear Improvement Charcoal Honey Mask to Purify & Nourish online.

Price: $$

Farmacy uses a blend of honey, propolis, and royal jelly (all compounds made by bees) in this mask. However, if you have sensitive skin, the company warns that the warming sensation may cause irritation.

Buy the Farmacy Honey Potion Renewing Antioxidant Hydration Mask online.

Using honey for face wash or as a face mask is not only popular. It may also benefit your skin. Thanks to honeys antibacterial, anti-inflammatory, and humectant properties, it may help prevent acne, calm irritation, and maintain hydration.

If used properly, washing [your] face with honey can help keep the skin looking younger, improve radiance and smoothness, and mitigate irritation and acne flare-ups, Vasyukevich says.

However, be mindful to use pure honey if you are going to DIY a treatment.

As with any skin care regimen, if you notice irritation, stop using the product or honey. If your skin seems fine, be patient and try your honey routine for at least a week to see if you notice any difference.

Brittany Risher is a writer, editor, and digital strategist specializing in health and lifestyle content. Shes written for publications including Elemental, Mens Health, Womens Health, and Yoga Journal.

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Honey for Face Wash: Should You Use It? - Healthline

Dr. David Arterburn discusses how bariatric surgery can be safe and effective in improving health for people who have obesity and type 2 diabetes.

Using medical records data, researchers with the National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study analyzed the five-year outcomes for more than 46,000 adults who underwent bariatric surgery (also called metabolic or weight-loss surgery). A subset of these adults had type 2 diabetes, and a separate analysis was conducted to determine the effectiveness of two types of surgery, sleeve gastrectomy and gastric bypass, for this group. Here, David Arterburn, MD, MPH, describes the study findings and discusses bariatric surgery guidelines for patients with type 2 diabetes.

Q: What were the PCORnet Bariatric Studys findings for people who have type 2 diabetes?

A: The good news is that the cumulative rates of diabetes remission during the five years after surgery are quite similar between the two procedures. The difference was 86.1 percent of patients achieving remission within 5 years of gastric bypass, compared with 83.5 percent for sleeve gastrectomy. We define diabetes remission as hemoglobin A1C that is less than 6.5 percent, the standard cut point for diagnosing diabetes, after being off diabetes medications for at least three months.

The not-so-good news is that the rate of relapse from diabetes remission within five years for patients who received sleeve gastrectomy was higher, at 41.6 percent, compared with the rate of relapse for gastric bypass patients, at 33.1 percent. If patients either restart their medication or have a hemoglobin A1C over 6.5, we say theyve relapsed.

Also, at five years, the hemoglobin A1C levels were lower in the gastric bypass patients, suggesting better glycemic control, than in the sleeve gastrectomy patients. It was half a percentage point difference, which is pretty large on the hemoglobin A1C scale. We know that good glycemic control is associated with reduced risk of having microvascular disease events and may also prevent macrovascular disease events. And so, it may be that the gastric bypass patients in the long term have fewer of those events than the sleeve gastrectomy patients. This study didnt look at that question, but it suggests that there is an advantage for patients with type 2 diabetes to have the gastric bypass procedure.

Weight loss may factor into the equation for some patients. In the full study, at five years, gastric bypass was associated with a greater average weight loss (56 pounds) than sleeve gastrectomy (41 pounds).

Q: How do the two procedures compare for safety?

A: We published a paper that finds clear differences on the safety side, but in the opposite direction. Patients who underwent a sleeve gastrectomy had fewer return visits to the hospital for reoperation or any hospitalization through five years of follow-up. The rate of reoperation or intervention that happens after the first procedure was 8.9 percent for sleeve gastrectomy patients and 12.3 percent for gastric bypass patients. The margin of difference in the rate of hospitalizations was even larger. At five years, it was 32.8 percent for the sleeve gastrectomy patients and 38.3 percent for the gastric bypass patients.

In terms of the risk of dying from the procedure, bariatric surgery is extremely safe, akin to having gallbladder surgery, which is a very commonly performed procedure. In our study, the 30-day risk of dying from the procedure was 0.2 percent for gastric bypass and 0.1 percent for sleeve gastrectomy. Over the last 20 to 30 years, the techniques for doing bariatric surgery have advanced greatly. In addition, were doing a better job of selecting patients for these kinds of procedures who can do well with them.

Q: How do patients with type 2 diabetes who are considering bariatric surgery decide between these two procedures?

A: Weve done some work to translate these findings into patient decision aids, which are educational tools to help patients talk about benefits and risks with their surgeon and come to an informed choice. Theres no one right choice for every patient. It really comes down to whats most important to the patient. [Note: Dr. Arterburn reviews benefits and risks in the short video,Helping Patients Choose between Weight Loss Surgery Options.]

Q: For which category of patients with type 2 diabetes is bariatric surgery recommended?

A: The current, most widely used guidelines say if you have type 2 diabetes thats not well-controlled on medical therapy, and you have a body mass index (BMI) thats greater than or equal to 35, you are eligible for bariatric surgery.

Randomized studies have compared gastric bypass or sleeve gastrectomy against best available medical care, including diet and exercise, intensive lifestyle treatment, and medical therapy. They have found that patients do better when they get bariatric surgery. Their glycemic control is better and their chance of remission from diabetes is quite a bit better, and thats even in the group of patients whose BMI is between 30 and 35.

The American Diabetes Association, the American Society for Metabolic and Bariatric Surgery, and other international organizations support recommendations suggesting that the criteria for bariatric surgery be expanded to include patients who have diabetes with a BMI as low as 30. It may actually be even safer for these patients, because they dont have quite as severe obesity, and therefore their risk of complications from the procedure appears to be at least as good or better as for people with greater obesity. It also may be that patients do better, in terms of a more durable remission of their diabetes and a lower risk of micro- and macrovascular disease, if we intervene earlier in terms of their obesity and diabetes. Insurance hasnt quite caught up yet, but Im hoping that as the evidence continues to mount, that we'll see an expansion in the eligibility for these procedures.

Q: What age range is suitable for bariatric surgery?

A: The PCORnet Bariatric Study included patients up to age 80, and the over-65 population seem to do just as well in terms of weight loss, diabetes outcomes, and risk of complications. They lost slightly less weight overall, but gastric bypass and sleeve gastrectomy performed the same in that regard. The older population has more general operative risk, but they arent at substantially greater risk from gastric bypass or sleeve gastrectomy than the younger-aged population.

We dont have as many studies in adolescents but, given the chronic progressive nature of type 2 diabetes, lifetime risk of developing complications from type 2 diabetes is pretty great. If youre an adolescent who already has severe obesity and youre developing diabetes, it seems like a very reasonable thing for you and your doctor and parents to discuss bariatric surgery.

Q: How challenging are the lifestyle changes required after bariatric surgery?

A: A good part of the decision aid tool we developed focuses on life after surgery in terms of diet, exercise, and life-long follow-up requirements. Many patients report that within one to two years after their procedure, some of the same food-related issues they had before surgery begin to emerge again, in terms of cravings or emotionally related eating. Having good psychological support can be very helpful to patients in the long term.

Q: How much weight do patients lose through bariatric surgery?

A: Most patients are maintaining the weight theyve lost. The average weight loss at five years was 25.5 percent of their weight at surgery for gastric bypass patients and 18.8 percent for sleeve gastrectomy patients. Average weight loss at five years is slightly lower for patients who have type 2 diabetes, 24.1 percent, and 16.1 percent, respectively.

We did a separate study of teens, age 12 to 18 years, who had severe obesity. It wasnt focused just on patients with type 2 diabetes, but we saw that patients in this study had similar weight loss as the adults. In fact, in the adolescents, sleeve gastrectomy seemed to do even better than it did with the adults. It was closer to gastric bypass in terms of its effect on weight loss at least through three years of follow-up.

We hear anecdotal stories about patients who regain all their weight, but its actually relatively uncommon for this to happen. Within five years, less than 5 percent of gastric bypass patients and less than 12 percent of sleeve gastrectomy patients regain weight to within 5 percent of where they started. The average patient maintains a substantial weight loss, which of course is whats responsible in large part to the improvement in their diabetes.

Q: The PCORnet Bariatric Study was observational and not a clinical trial. Why is this important?

A: The cohort for our study was drawn from medical records databases, so the data is from patients and providers going about their usual care. There could be differences between patients who choose gastric bypass and patients who choose sleeve gastrectomy. Thats why randomized trials are generally considered the gold standard. Although we used advanced statistical techniques to try to balance all the measurable factors between the two groupslike age, sex, race, ethnicity, hemoglobin A1C at the time of surgery, and severity of diabetestheres still the potential that there are other reasons why patients were having differences in their outcomes that arent related to the procedure itself.

The randomized trials generally show that when you take patients with diabetes and you randomly assign them to either gastric bypass or sleeve gastrectomy, the differences in the rates of remission and hemoglobin A1C improvement are smaller than what we found in the PCORnet Study. But whats interesting about our real-world data, is it shows that the gastric bypass patients do better in routine clinical practice. We dont exactly know why that is.

Our next line of research is to begin to develop better, individualized prediction models and incorporate that information into those decision aids that I was talking about. The individualized model would provide patients with specific predictions, based on their personal characteristics, about their chance of durable remission or relapse of their diabetes, developing micro- or macrovascular disease from their diabetes, dying over time, expected weight loss, and risk of having a reoperation or a rehospitalization.

How do you present information on weight-loss surgery to your patients with type 2 diabetes? Tell us below in the comments.

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Bariatric (Weight-Loss) Surgery to Treat Type 2 Diabetes | NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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