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When New York City gyms closed in mid-March, Equinox instructor Amanda Katz was immediately out of work. But instead of discontinuing her classes, she began lifting weights, leading ab workouts and sweating with her students on Instagram Live. Although going from working in a fitness studio to her studio apartment took some getting used to, Katz knew she had a responsibility to give her clients some sense of routine throughout a period of uncertainty.

Our current climate feels out of control, she said. If there is one consistent activity in my communitys schedule that also brings them joy, then Ive done my job.

Those who were once opposed to at-home exercise have had no choice but to make do with what is available online, and even after fitness centers reopen and workout classes start up again, experts predict the industry will still feel the effects of this forced digitalization. Fitness brands will need to tailor their messages to consumers to address health concerns, incorporate remote fitness plans and prioritize exercise enjoyment over visible results.

The industry is going through a digital disruption, said Allen Adamson, co-founder of Metaforce and professor at NYUs Stern School of Business. Quarantine has accelerated changes that were already happening. If youre trying to build a digital business, now is the time to step on the gas because now everyone is a potential customer.

This disruption comes as consumers may be even more concerned with staying in shape than they were before, which is something brands need to be cognizant of.

People become anxious when they arent moving in the way that they used to, said nutrition counselor and fitness instructor Caitie Corradino. It has only amplified body image and weight concerns that they were already having.

The industry is going through a digital disruption. Quarantine has accelerated changes that were already happening. If youre trying to build a digital business, now is the time to step on the gas because now everyone is a potential customer.

Allen Adamson, co-founder of Meta Force and professor at NYU Stern.

Since the beginning of quarantine, fitness companies have found creative ways to engage their members remotely by expanding online services, livestreaming workouts on social media and offering additional lifestyle content, such as healthy recipes and family workouts.

Although consumers have adjusted to at-home workout routines, many leaders in the industry predict that once stay-at-home orders are lifted, members will be ready to head back to the gym.

Sharad Mohan, the CEO and co-founder of the personal training software Trainerize, said the social element of the gym is what members miss the most, suggesting fitness brands run in-gym challenges that spark healthy competition and camaraderie, run limited-edition, in-person classes or offer up free trials for in-person training.

Chad Waetzig, evp of marketing and branding at Crunch Fitness, said 83% of its members were anxious to get back to the gym. There is a certain social component, the benefit of getting proper coaching, and it is incredibly motivating for some people.

Waetzig shared that roughly half of Crunch members were dissatisfied with their at-home fitness program.

Mohan also predicted that the industry will see a long period of transition and apprehension before members are ready to head back to the gym. In order to combat that reluctance, Mohan suggested fitness companies focus on a hybrid of in-person and remote services while focusing on community-based initiatives.

Orangetheory Fitness has done just that, expanding at-home workouts for both members and nonmembers during quarantine. Chief brand officer Kevin Keith said that the pandemic greatly accelerated the brands plans to evolve as a hybrid in-studio and digital fitness model, adding that its in-home workouts arent meant to replace the in-studio experience.

To address health concerns, Planet Fitness has promised heightened cleanliness by introducing the The Clean Thumb Club initiative. The company will use touchless check-ins, install more cleaning stations and temporarily halt the use of cardio equipment that does not comply with social distancing.

In order to survive the digitalization of the industry, Adamson stressed that now is the time to push. As consumers see online fitness as a reliable alternative, he said, trainers and gyms must continue to offer these resources while also reminding clients of the social aspects they may miss about the gym.

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Originally posted here:
Even as Gyms Reopen, the Pandemic Will Still Impact How and Why Consumers Exercise - Adweek

Bagsvrd, Denmark, 13 June 2020 Novo Nordisk today announced results from a responder analysis of the PIONEER 15 and 8 trials, which showed that Rybelsus (oral semaglutide 14 mg) was more effective in achieving a blood sugar reduction of greater than or equal to 1% together with body weight reduction of greater than or equal to 5% compared to sitagliptin, empagliflozin and liraglutide in people with type 2 diabetes (p<0.0001).1 The results were presented during the American Diabetes Association 80th Scientific Sessions.1

The composite endpoint of blood sugar reductions of greater than or equal to 1% and body weight loss of greater than or equal to 5% was achieved by 2741% of people treated with Rybelsus 14 mg compared with 11% of people treated with sitagliptin 100 mg; 18% with liraglutide 1.8 mg; 20% with empagliflozin 25 mg and 18% with placebo.1

Additionally, across the trials, any reduction in blood sugar was seen in higher proportions of people treated with Rybelsus (8995%) than those treated with active comparators (8288%) or with placebo (5164%). Any reduction in blood sugar and body weight was seen in 7286% of people treated with Rybelsus.1

Controlling blood sugar levels and managing weight are challenges faced by many people living with type 2 diabetes, which can have serious consequences for long-term health, said Associate Professor Kathleen Dungan, study investigator, The Ohio State University, Columbus, US. The results of this responder analysis indicate that oral semaglutide has the potential to help more people with type 2 diabetes achieve clinically relevant blood sugar and weight goals compared with other commonly used oral antidiabetic medicines.

In 2019, an estimated 463 million people worldwide were living with diabetes, 90% of whom were living with type 2 diabetes.2 Despite the availability of many treatment options for type 2 diabetes, more than half of people living with the condition do not achieve target blood sugar levels,3 pointing to the need for efficacious treatment options.

This analysis reinforces the strong clinical profile of Rybelsus demonstrated in the phase 3a clinical trial programme, said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk. Based on this growing evidence base, combined with its oral formulation, we believe Rybelsus has the potential to set a new standard for the treatment of type 2 diabetes.

For more news and media materials from Novo Nordisk at ADA 2020, please visit https://www.epresspack.net/novonordiskADA2020/post-hoc-analysis-pioneer/

About Rybelsus

Rybelsus (oral semaglutide), an analogue of the naturally occurring hormone glucagon-like peptide-1 (GLP-1), is the first and only GLP-1 receptor agonist in a pill. In the EU, Rybelsus is indicated for the treatment of adults with insufficiently controlled type 2 diabetes to improve glycaemic control as an adjunct to diet and exercise. It is administered once daily and is approved for use in two therapeutic dosages, 7 mg and 14 mg.4

About PIONEER clinical trial programme

PIONEER (Peptide Innovation for Early Diabetes Treatment) is the global phase 3a clinical trial programme that investigated Rybelsus for the treatment of type 2 diabetes. The clinical trial programme involved 9,543 people with type 2 diabetes across 10 clinical trials. The programme evaluated the safety and efficacy of Rybelsus in people with type 2 diabetes vs other glucose-lowering therapies for type 2 diabetes, including SGLT-2i, DPP-4i, GLP-1 receptor agonists and as an add-on to insulin.5-14

About Novo Nordisk

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 43,100 people in 80 countries and markets its products in around 170 countries. For more information, visit novonordisk.com, Facebook, Twitter, LinkedIn, YouTube.

Further information

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References

1. Dungan K, Hertz CL, Mellbin L, et al. Glycemic and Body Weight Responses to Oral Semaglutide in the PIONEER Trial Program. Abstract 964-P. Presented during the 80th Scientific Sessions of the American Diabetes Association, General Poster Session 2, 13:00 CDT on 13 June 2020.

2. International Diabetes Federation. IDF Diabetes Atlas 9th edition, 2019. Available at: https://www.diabetesatlas.org/en/resources/ Last accessed: June 2020.

3. Raccah D, Chou E, Colagiuri S, et al. A global study of the unmet need for glycemic control and predictor factors among patients with type 2 diabetes mellitus who have achieved optimal fasting plasma glucose control on basal insulin. Diabetes Metab Res Rev. 2017;33.

4. EMA. Rybelsus Summary of Product Characteristics. Available at: https://www.ema.europa.eu/en/medicines/human/EPAR/rybelsus. Last accessed: June 2020.

5. Aroda VR, Rosenstock J, Terauchi Y, et al. PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes. Diabetes Care. 2019;42:1724-1732.

6. Rodbard HW, Rosenstock J, Canani LH, et al. Oral Semaglutide Versus Empagliflozin in Patients With Type 2 Diabetes Uncontrolled on Metformin: The PIONEER 2 Trial. Diabetes Care. 2019;42:2272-2281.

7. Rosenstock J, Allison D, Birkenfeld AL, et al. Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial. JAMA. 2019;321:1466-1480.

8. Pratley R, Amod A, Hoff ST, et al. Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial. Lancet. 2019;394:39-50.

9. Mosenzon O, Blicher TM, Rosenlund S, et al. Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes Endocrinol. 2019;7:515-527.

10. Husain M, Birkenfeld AL, Donsmark M, et al. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2019;381:841-851.

11. Pieber TR, Bode B, Mertens A, et al. Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial. Lancet Diabetes Endocrinol. 2019;7:528-539.

12. Zinman B, Aroda VR, Buse JB, et al. Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial. Diabetes Care. 2019;42:2262-2271.

13. Yamada Y, Katagiri H, Hamamoto Y, et al. Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial. The Lancet Diabetes & Endocrinology. 2020;8:377-391.

14. Yabe D, Nakamura J, Kaneto H, et al. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial. The Lancet Diabetes & Endocrinology. 2020;8:392-406.

Originally posted here:
Rybelsus was more effective in achieving clinically relevant blood sugar and weight reductions in people with type 2 diabetes vs all active comparato...

Mens health issues are brought to light during Mens Health Week annually to generate further awareness of these diseases, which include cancer, the number 1 cause of death in the United States. The likelihood of men developing cancer during their lifetime is 50%, whereas women have about a 33% chance of developing cancer. Overall, men are at a greater risk of developing cancer and should consider screening recommendations, as well as preventative measures that they can take.

The consumption of red and processed meat, which is considered a class 2a carcinogen by the World Health Organization (WHO), should be minimized. Low-fat diets and exercise are also important preventative measures that men could take to help avoid a diagnosis of cancer during their lifetime.

Prostate cancer, specifically, is a unique cancer type in the male patient population, but men also may run the risk of developing lung, colon, rectal, and pancreatic cancer as well. In terms of screening, men are recommended to begin screening for colorectal cancer (CRC) at the age of 50 years, but the American Cancer Society recommends that suggest screening begin earlier at the age of 45 years. For prostate cancer, screening discussions should begin around the age of 50, but it is also important to consider the patients family history of cancer that may put them at a greater risk of developing cancer.

In an interview with Targeted Oncology, Hagen F. Kennecke, MD, MHA, FRCP, medical oncologist, medical director of the Virginia Mason Cancer Institute and current chair of the NCI Rectal-Anal Cancer Task Force, discussed the prevalence of cancers, particularly CRC and prostate cancer, in the male population. He also spoke to screening recommendations and preventative measures that can help reduce the risk of developing cancer.

TARGETED ONCOLOGY: Could you discuss the prevalence of cancer in the male patient population compared with females, and what does the prognosis look like?

Kennecke: Cancer is now the number 1 cause of death in many parts of the United States andoverall, men are at a 50% likelihood of having some sort of cancer diagnosed in their lifetime, where it is slightly lower in women at about a third. Overall, the burden of cancer is higher for men.

The male unique cancer is prostate cancer, which is number 2 in terms of mortality behind lung cancer. For both men and women, colorectal cancer is the third most common cause of cancer mortality, otherwise, cancers are quite non-gender discriminatory. In CRC, men and women are equally affected. Pancreas cancer is sometimes more common in males, but this is not a strong trend.

TARGETED ONCOLOGY: Could you discuss what men should be getting testing done for cancer? For men with a family history of cancer in particular, what steps should they be taking?

Kennecke: In CRC, the current national guidelines recommend, regardless of family history, to start screening at age 50. The American Cancer Society suggest starting at age 45, but that is due to a significant recent increases in cancers diagnosed less than age 50. At the very latest, men should start testing at 50 or even 45 years of age, particularly if there is a family history.

When it comes to prostate cancer, that is a much longer-winded answer. There is some evidence to support screening for prostate cancer in the form of a PSA blood test. There is a lot of discussions, however, on when the best time is to start testing and what the best thing to do is if a diagnosis of an early-stage prostate cancer occurs. Overall, although the recommendation is to start the conversation for prostate cancer screening at age 50 in average-risk men and age 40 to 45 in men with a family history and in African American men who are also at higher risk of the cancer. It is important to define that family history, and a family history is a first-degree relative, so a brother or parent at the age of less than 65 years. When we talk about family history, it is important to be specific about that.

TARGETED ONCOLOGY: Could you provide an overview of the current treatment options in CRC and prostate cancer?

Kennecke: The cornerstone of CRC generally involves a diagnosis that has been made, which is generally made with a colonoscopy, and then treatment involves a surgery. Once that is done, the surgery is generally not significantly morbid. Particularly for patients diagnosed with rectal cancer, it is important that this surgery is done by a colorectal surgeon due to the complexities of pelvic surgery and the rapidly changing treatment paradigms for this cancer. In terms of further therapy, that depends on how advanced the tumor is. If the cancer has gone to the lymph nodes, then we most often offer chemotherapy to reduce the risk of future recurrence. For rectal cancer, it is different because this is a cancer where it is better to give radiation before surgery which was been shown to be more effective and have less side effects. A colorectal surgeon will be familiar with these requirements and generally initiate the referral to medical and radiation oncology. For rectal cancer, there is also an increasing trend tooffer chemotherapy before surgery which may decrease the need for a permanent colostomy.

For prostate cancer, there are many treatment options, and I would also like to point to decision aids. Decision aids that involve the patient are offered online by the American Cancer Society, as well as the American Society of Clinical Oncology, Mayo Clinic, and other major cancer organizations. It helps initiate the discussion about not only screening but 1 of the things that happens is many prostate cancers that are diagnosed are very early stage and may not necessarily require any initial treatment. That is where there is a continuum between the screening and treatment discussions. It is not quite as black and white as with other cancers. Overall, though, if treatment is required, that is usually for those that have established high-risk criteria. The options are either a surgical approach to remove the prostate and surrounding tissue or a radiation approach, which involves seeds implanted into the prostate or external radiation. It may also require all of those things if the tumor is high risk and meets certain criteria.

TARGETED ONCOLOGY: What should physicians keep in mind when they are treating their male patients with either prostate cancer or CRC?

Kennecke: In terms of men in general, they are not as good as women when it comes to follow-up and seeing primary care doctors and pursuing screening as much as they should. You should continue to encourage that screening discussion. When it comes to actual toxicities that are unique to men, we do know that rectal and prostate cancers are an area where men are more likely to experience sexual, bowel and bladder dysfunction after treatment. From a treatment perspective, those are very important subjects that should be discussed prior to initiating therapy. There are also new ways of treating rectal cancer designed to reduce the long-term toxicities and reduce the use of permanent colostomies. For prostate cancer, we know that cancer of survival of men who are diagnosed with early stage prostate cancer is very high, which makes it important to balance the treatment versus the disease and its side effects. There is a lot of emphasis on quality of life and survivorship.

TARGETED ONCOLOGY: What would you like for community oncologists to know when they are treating men with cancer?

Kennecke: I have an incredible amount of respect for community oncologists. They are very knowledgeable and take care of many different cancer types whose treatment is rapidly changing.At times it is necessary refer for those cancer patients that need extra attention for special care while making arrangement for the remainder of treatment and follow-up to be offered closer to home. We know that can make a difference, and I think overall, talking about the risks and benefits of therapy, and involving the patients in that is really important.

TARGETED ONCOLOGY: What is your main message now in regard to diagnosing and treating men with cancer?

Kennecke: Cancer touches almost everyone, directly or indirectly and we need to have balanced discussions about treatment and outcomes. Today we talked a lot about screening and treatment, and we need to remember prevention, which all about healthy habits for the rest of our lives. Things like reducing red and processed meat, a low fat, high fiber diet, exercise and weight loss are key to prevention of colorectal and prostate cancer. We cannot say this often enough.

See original here:
Preventative Measures and Cancer Screening Recommendations Aid Male Population - Targeted Oncology

The weight loss industry is full of myths.

People are often advised to do all sorts of crazy things, most of which have no evidence behind them.

However, over the years, scientists have found a number of strategies that seem to be effective.

Here are 26 weight loss tips that are actually evidence-based.

It is often claimed that drinking water can help with weight loss and thats true.

Drinking water can boost metabolism by 2430% over a period of 11.5 hours, helping you burn off a few more calories (1, 2).

One study showed that drinking a half-liter (17 ounces) of water about half an hour before meals helped dieters eat fewer calories and lose 44% more weight, compared to those who didnt drink the water (3).

Eating whole eggs can have all sorts of benefits, including helping you lose weight.

Studies show that replacing a grain-based breakfast with eggs can help you eat fewer calories for the next 36 hours as well as lose more weight and body fat (4, 5).

If you dont eat eggs, that's fine. Any source of quality protein for breakfast should do the trick.

Coffee has been unfairly demonized. Quality coffee is loaded with antioxidants and can have numerous health benefits.

Studies show that the caffeine in coffee can boost metabolism by 311% and increase fat burning by up to 1029% (6, 7, 8).

Just make sure not to add a bunch of sugar or other high-calorie ingredients to your coffee. That will completely negate any benefits.

You can shop for coffee at your local grocery store, as well as online.

Like coffee, green tea also has many benefits, one of them being weight loss.

Though green tea contains small amounts of caffeine, it is loaded with powerful antioxidants called catechins, which are believed to work synergistically with caffeine to enhance fat burning (9, 10).

Although the evidence is mixed, many studies show that green tea (either as a beverage or a green tea extract supplement) can help you lose weight (11, 12).

Green tea is available at most pharmacies, health stores, and grocery stores, as well as online.

Intermittent fasting is a popular eating pattern in which people cycle between periods of fasting and eating.

Short-term studies suggest intermittent fasting is as effective for weight loss as continuous calorie restriction (13).

Additionally, it may reduce the loss of muscle mass typically associated with low-calorie diets. However, higher-quality studies are needed before any stronger claims can be made (14).

A fiber called glucomannan has been linked to weight loss in several studies.

This type of fiber absorbs water and sits in your gut for a while, making you feel more full and helping you eat fewer calories (15).

Studies show that people who supplement with glucomannan lose a bit more weight than those who don't (16).

You can find glucomannan supplements not only at vitamin shops and pharmacies but also online.

Added sugar is one of the worst ingredients in the modern diet. Most people consume way too much.

Studies show that sugar (and high-fructose corn syrup) consumption is strongly associated with an increased risk of obesity, as well as conditions including type 2 diabetes and heart disease (17, 18, 19).

If you want to lose weight, cut back on added sugar. Just make sure to read labels, because even so-called health foods can be loaded with sugar.

Refined carbohydrates include sugar and grains that have been stripped of their fibrous, nutritious parts. These include white bread and pasta.

Studies show that refined carbs can spike blood sugar rapidly, leading to hunger, cravings and increased food intake a few hours later. Eating refined carbs is strongly linked to obesity (20, 21, 22).

If you're going to eat carbs, make sure to eat them with their natural fiber.

If you want to get all the benefits of carb restriction, then consider going all the way and committing to a low-carb diet.

Numerous studies show that such a regimen can help you lose 23 times as much weight as a standard low-fat diet while also improving your health (23, 24, 25).

Using smaller plates has been shown to help some people automatically eat fewer calories (26).

However, the plate-size effect doesnt appear to affect everyone. Those who are overweight seem to be more affected (27, 28).

Portion control simply eating less or counting calories can be very useful, for obvious reasons (29).

Some studies show that keeping a food diary or taking pictures of your meals can help you lose weight (30, 31).

Anything that increases your awareness of what you are eating is likely to be beneficial.

Keeping healthy food nearby can help prevent you from eating something unhealthy if you become excessively hungry.

Snacks that are easily portable and simple to prepare include whole fruits, nuts, baby carrots, yogurt and hard-boiled eggs.

Taking probiotic supplements containing bacteria of the Lactobacillus subfamily have been shown to reduce fat mass (32, 33).

However, the same doesnt apply to all Lactobacillus species. Some studies have linked L. acidophilus with weight gain (34).

You can shop for probiotic supplements at many grocery stores, as well as online.

Chili peppers contain capsaicin, a spicy compound that can boost metabolism and reduce your appetite slightly (35, 36).

However, people may develop tolerance to the effects of capsaicin over time, which may limit its long-term effectiveness (37).

Doing aerobic exercise (cardio) is an excellent way to burn calories and improve your physical and mental health.

It appears to be particularly effective for losing belly fat, the unhealthy fat that tends to build up around your organs and cause metabolic disease (38, 39).

One of the worst side effects of dieting is that it tends to cause muscle loss and metabolic slowdown, often referred to as starvation mode (40, 41).

The best way to prevent this is to do some sort of resistance exercise such as lifting weights. Studies show that weight lifting can help keep your metabolism high and prevent you from losing precious muscle mass (42, 43).

Of course, it's important not just to lose fat you also want to build muscle. Resistance exercise is critical for a toned body.

Fiber is often recommended for weight loss.

Although the evidence is mixed, some studies show that fiber (especially viscous fiber) can increase satiety and help you control your weight over the long term (44, 45).

Vegetables and fruits have several properties that make them effective for weight loss.

They contain few calories but a lot of fiber. Their high water content gives them low energy density, making them very filling.

Studies show that people who eat vegetables and fruits tend to weigh less (46).

These foods are also very nutritious, so eating them is important for your health.

Sleep is highly underrated but may be just as important as eating healthy and exercising.

Studies show that poor sleep is one of the strongest risk factors for obesity, as its linked to an 89% increased risk of obesity in children and 55% in adults (47).

A recent study found that 19.9% of people in North America and Europe fulfill the criteria for food addiction (48).

If you experience overpowering cravings and can't seem to curb your eating no matter how hard you try, you may suffer from addiction.

In this case, seek professional help. Trying to lose weight without first combating food addiction is next to impossible.

Protein is the single most important nutrient for losing weight.

Eating a high-protein diet has been shown to boost metabolism by 80100 calories per day while shaving 441 calories per day off your diet (49, 50, 51).

One study also showed that eating 25% of your daily calories as protein reduced obsessive thoughts about food by 60% while cutting desire for late-night snacking in half (52).

Simply adding protein to your diet is one of the easiest and most effective ways to lose weight.

If you struggle to get enough protein in your diet, taking a supplement such as protein powder can help.

One study showed that replacing some of your calories with whey protein can cause weight loss of about 8 pounds over time while increasing muscle mass (53).

Whey protein is available at most health stores and online.

Sugar is bad, but sugar in liquid form is even worse. Studies show that calories from liquid sugar may be the single most fattening aspect of the modern diet (54).

For example, one study showed that sugar-sweetened beverages are linked to a 60% increased risk of obesity in children for each daily serving (55).

Keep in mind that this applies to fruit juice as well, which contains a similar amount of sugar as a soft drink like Coke (56).

Eat whole fruit, but limit or avoid fruit juice altogether.

One of the biggest problems with diets is that they rarely work in the long term.

If anything, people who diet tend to gain more weight over time, and studies show that dieting is a consistent predictor of future weight gain (57).

Instead of going on a diet, aim to become a healthier, happier and fitter person. Focus on nourishing your body instead of depriving it.

Weight loss should then follow naturally.

Your brain may take a while to register that you've had enough to eat. Some studies show that chewing more slowly can help you eat fewer calories and increase the production of hormones linked to weight loss (58, 59).

Also consider chewing your food more thoroughly. Studies show that increased chewing may reduce calorie intake at a meal (60).

These practices are a component of mindful eating, which aims to help you slow down your food intake and pay attention to each bite.

Numerous techniques can aid your weight loss goals.

Some of the above tips are purely dietary, involving eating more protein or cutting back on added sugar.

Others such as improving sleep quality or adding a workout routine are more lifestyle-based. For example, chewing more slowly is one step you can take to institute mindful eating.

If you implement a handful of these tips, you'll be well on your way to your weight loss goals.

Originally posted here:
26 Weight Loss Tips That Are Actually Evidence-Based

Pumping iron and pounding the treadmill may not boost your sex appeal after all, according to a Scottish study that suggests efforts to achieve the perfect body are misguided.

New research suggests that many women favour slim and less muscular men, which may surprise many of Britains gym fanatics.

The study, by St Andrews University, also found that men generally prefer a woman with a fuller figure.

Academics claim that the findings, published in the British Journal of Psychology, challenge commonly held notions of attractiveness in western societies and could help to tackle body image and eating disorders that have risen in recent years.

For the St Andrews study, 169 heterosexual men and women aged between 18-31 were presented with images of male and female

Original post:
Forget the gym: St Andrews study finds weight loss and muscles don't work out for the opposite sex - The Times

A new study offers the first evidence that a protein named BAM15 acts as an energy uncoupler and could be an effective drug for treating obesity and related diseases.

Obesity affects more than 650 million people worldwide and drives a number of dangerous health conditions, including type 2 diabetes, heart disease and more than a dozen deadly cancers. Global spending to treat obesity and obesity-related illnesses amounts to well above $150 billion a year.

Despite this, only a handful of medications are currently FDA-approved for obesity treatment, and the people who take these drugs rarely achieve long-term weight loss, said John Kirwan, Ph.D., Executive Director of the Pennington Biomedical Research Center in Baton Rouge, Louisiana.

Halting the obesity epidemic requires new, more effective medications. This research represents a very promising step in the discovery process. We hope that in the not-too-distant future, BAM15 or related compounds will advance to clinical drug development and become a viable treatment option for patients with obesity.

BAM15 prevents weight gain, fat buildup and reduces blood sugar. Credit: Graphic by Kathryn Pergola

BAM15 differs from the existing weight-management medications, which largely work by reducing the amount of food a person eats or the calories their bodies absorb. BAM15 works by making the mitochondria, the power plants of the cell, less efficient. The result is that the mitochondria burn more energy.

Researchers believe BAM15 could be used to treat a number of health conditions including diabetes, fatty liver disease, and some forms of cancer.

In the new study, Pennington Biomedical scientists show for the first time that mice given BAM15 are resistant to weight gain by burning more calories than their untreated counterparts. Other benefits of BAM15 include:

The study BAM15 Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control was published in the journalEMBO Molecular Medicine.

Reference: BAM15mediated mitochondrial uncoupling protects against obesity and improves glycemic control by Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel and John P Kirwan, 10 June 2020, EMBO Molecular Medicine.DOI: 10.15252/emmm.202012088

Originally posted here:
Potential Treatment for Obesity Discovered: Drug Prevents Weight Gain and Reduces Blood Sugar - SciTechDaily

Diet vs. Exercise: Which One Has a Greater Effect on Your Bodys Capacity to Lose Weight?Losing weight and keeping it off for the long run is a huge challenge for thousands of Americans. Everyone knows they should maintain a healthy weight but achieving this goal can be really difficult. Starting with a checkup at the primary physicians office is a good start.

Then, armed with the health check-up results, seek help ion losing the extra pounds and keeping them off. It often takes a combination of a healthy diet and regular exercise. But, which thing makes the most impact of our ability to lose weight?

Obesity affects more than a persons looks. When a person gains too much weight they can develop health problems including joint issues, high blood pressure, heart disease, diabetes, increased chance of cancer, and other health problems. Overweight people suffer more pain and inflammation as well as bone and joint issues.

There are many ways to lose weight and find exercise programs. Some people rely on their physicians to advise them, some get a trainer at their local fitness facility, and others choose a diet and lifestyle program. First Fitness Nutrition has options that include supplements and dietary changes that guide a person through the weight loss program while giving them advice on how to live a healthier life eating better foods.

Though many people can tackle weight loss and exercise programs on their own, others prefer to sign up for a well-designed program that gives them more help along the way. The supplements and products that support the weight loss program help a person curb their appetite, burn more fat and have more energy while they start their weight loss program. This is backed up with a proven and supportive program to learn how to eat healthier foods and make lifestyle changes that support weight loss for the long term.

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These programs give people the guidance and personal help they feel they need to stay on a weight loss program. It gives them lifestyle changes to make a little at a time. A short term diet will never work for the long term and weight lost will come back. To keep weight off, a person must permanently change their lifestyle. Having guidelines will help make the best changes in the least painful ways.

People must change their relationship with food. Eating for comfort or because a person is bored must end. Eating when one is hungry and eating the right foods in the correct amounts is important.

Eating less food and better food will help a person lose weight. But without exercise, a person loses not only fat but the muscle and bone density. A combination of a healthy diet and exercise increases the weight loss benefits. With a good exercise program, a person will lose mostly fat while building muscle and retaining bond density. A person should aim for five to seven 50 minute workouts each week. If that is not possible, do what is possible.

Even though the dieting is about 75% of weight loss and exercising only 25%, that is an important 25%. Exercise has added benefits for a persons overall health. Exercise can improve the quality of a persons sleep, reduce their stress level, and lower cholesterol. Exercise also helps a person grow muscle and improve bone density.

Looking better and feeling better are two important benefits of losing weight. But there are more benefits to losing weight in a healthy way:

Though a person can burn calories exercising, it will not result in substantial weight loss if a person is practicing poor nutrition or is eating too many calories. Nutrition makes the most impact on losing weight but exercising is also important. In the end, it turns out that a successful weight loss program depends on both diet and exercise to be successful for then long term.

When a person is losing a lot of weight, it is important to exercise to help the body look its best with less weight. No one wants to lose weight only to deal with loose skin flaps and a loss of muscle tone. Exercise helps the body adjust to the weight loss by replacing fat with more muscles and improving skin tone. Cutting calories and burning calories through exercise can be more effective than relying on either one alone.

A healthy diet to lose weight is one that can be sustained over a long period of time and causes a person to consume fewer calories than they burn. But people who cut calories too much can be bad for ones health and can not be sustained so when calories are increased to normal levels the weight comes back. Experts suggest that a person eat 10 calories per pound of body weight. So a 150-pound person would consume an average of 1500 calories per day and lose weight. A 200-pound man would be able to consume 2,000 calories and lose weight.

A good weight loss diet lasts forever and is based on changing eating habits permanently. A balanced diet consists of lots of fruits and vegetables, lean proteins, and whole grains. The person who wants to lose weight must cut back on carbohydrates, sugars, and starches as well as fats. Some lean proteins include meats such as beef, chicken, pork, and lamb, fish and seafood, whole eggs, and plant-based proteins like beans, legumes, and soy.

A person can eat a lot of low carb vegetables to get nutritional benefits with few calories. They contain fiber, minerals, and vitamins a person needs to stay healthy. Low carb vegetables include broccoli, kale, spinach, cauliflower, tomatoes, cabbage, cucumbers, lettuce, Swiss chard, and more. Avoid the bad fats but eat healthy fats such as limited amounts of butter, olive oil, and avocado oil. Each meal should include protein, fat, and low carbohydrate vegetables or fruit. Experts also advise drinking plenty of water.

Studies show that people have more success with low carbohydrate diets than low-fat diets for short term weight loss. People who are trying to lose weight and keep it off should avoid or limit the intake of certain foods:

It is not necessary to totally avoid all of the foods a person likes. Eating a treat once in a while does not hurt. Avoiding unhealthy foods does not mean a person can never eat them. It is important for a person who is trying to eat healthier and lose weight to not feel like they are giving up too much. It is also good to learn what good tasting enjoyable but healthier foods can be substituted for less healthy foods.

A long term diet needs to be satisfying and enjoyable or the person will not stick with it. The person should seek the advice of nutritional and diet experts to plan a healthy eating lifestyle they will enjoy over the long term. There should be a lot of food choices available in every category. A person should also have a plan for foods to order in restaurants or eat at parties that are healthy. Changing to healthier eating habits has long term benefits for losing weight and keeping it off and for general health.

Mayo Clinic Minute: Which is better for losing weight diet or exercise?

DIET vs EXERCISE The BEST For Losing Weight

Exercise vs Diet

DIET vs EXERCISE Episode 1: Fat Loss Diet versus Best Cardio Workout to Burn Belly Fat

Diet vs Exercise For Weight Loss

THE BASICS OF LOSING WEIGHT DIET vs TRAINING

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Diet vs. Exercise: Which One Has a Greater Effect to Lose Weight? - Women Fitness

DetailsCategory: Proteins and PeptidesPublished on Saturday, 13 June 2020 12:29Hits: 266

BAGSVAERD, Denmark I June 12, 2020 I Novo Nordisk today announced headline results from the final two phase 3a clinical trials investigating once-weekly subcutaneous (sc) semaglutide 2.4 mg for weight management. STEP 2 in adults with obesity and type 2 diabetes (T2D) and STEP 3 as an adjunct to intensive behavioural therapy (IBT) in adults with obesity.

STEP 2 (obesity and type 2 diabetes)STEP 2 is a 68-week randomised, double-blind, multicentre, placebo-controlled trial. The trial compared the efficacy and safety of once-weekly sc semaglutide 2.4 mg after 68 weeks to placebo and once-weekly sc semaglutide 1.0 mg. Treatment was provided in conjunction with lifestyle intervention, in 1,210 adults with T2D and either obesity or overweight with comorbidities.

The trial met both primary endpoints. In all people randomised1, a statistically significant greater weight loss of 9.6% was achieved at 68 weeks with sc semaglutide 2.4 mg, from a mean baseline bodyweight of 99.8 kg, compared to placebo (3.4% weight loss) and sc semaglutide 1.0 mg (7.0% weight loss). 68.8% of those who received sc semaglutide 2.4 mg achieved a weight loss of 5% or more after 68 weeks, compared to 28.5% with placebo.

When evaluating the effects of treatment if taken as intended2, people treated with sc semaglutide 2.4 mg achieved a weight loss of 10.6%, compared to a 3.1% weight loss with placebo and 7.5% weight loss with semaglutide 1.0 mg at 68 weeks. 73.2% of those who stayed on sc semaglutide 2.4 mg for 68 weeks achieved a weight loss of 5% or more, compared to 27.6% with placebo.

STEP 3 (adjunct to intensive behavioural therapy)STEP 3 is a 68-week randomised, double-blind, multicentre, placebo-controlled trial. The trial investigated the effect of once-weekly sc semaglutide 2.4 mg after 68 weeks compared to placebo in 611 adults with obesity or overweight with comorbidities. Both treatments were in conjunction with IBT, defined as weekly behavioural support, dietician counselling and reduced calorie diet.

The trial met both of its primary endpoints. In all people randomised1, a statistically significantly greater weight loss of 16.0% was achieved with sc semaglutide 2.4 mg as an adjunct to IBT, from a mean baseline bodyweight of 105.8 kg, compared to a 5.7% weight loss with placebo plus IBT after the 68week treatment period. 86.6% of those treated with sc semaglutide 2.4 mg achieved a weight loss of 5% or more after 68 weeks as an adjunct to IBT, compared to 47.6% with placebo plus IBT.

When evaluating the effects of treatment if taken as intended2, people treated with sc semaglutide 2.4 mg plus IBT achieved a weight loss of 17.6%, compared to a 5.0% weight loss with placebo plus IBT. 89.8% of those who received sc semaglutide 2.4 mg plus IBT achieved a weight loss of 5% or more after 68 weeks, compared to 50.0% with placebo plus IBT.

In both STEP 2 and STEP 3, sc semaglutide 2.4 mg appeared to have a safe and welltolerated profile, consistent with previous findings. The most common adverse events among people treated with sc semaglutide 2.4 mg were gastrointestinal events. Most events were transient, and mild or moderate in severity.

These results continue to build on the highly impressive weight loss reported previously in STEP 1 and 4. Altogether, the results indicate that semaglutide 2.4 mg will play a key role in improving the treatment of people with obesity, said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk. We have now reported on all the four trials in the STEP programme and we look forward to sharing the results with regulatory authorities.

About obesity and sc semaglutide 2.4 mg for weight management Obesity is a chronic disease that requires long-term management. It is associated with many serious health consequences and decreased life expectancy. Obesity-related complications are numerous and include T2D, heart disease,obstructive sleep apnoea, chronic kidney disease, non-alcoholic fatty liver disease and cancer.

Once-weekly sc semaglutide 2.4 mg is being investigated by Novo Nordisk as a treatment for adults with obesity. Semaglutide is an analogue of the human glucagonlike peptide-1 (GLP-1) hormone. It induces weight loss by reducing hunger, increasing feelings of fullness and thereby helping people eat less and reduce their calorie intake.

About the STEP clinical programme STEP (Semaglutide Treatment Effect in People with obesity) is a phase 3 clinical development programme with once-weekly sc semaglutide 2.4 mg in obesity. The global clinical phase 3a programme consists of four trials and has enrolled approximately 4,500 adults with overweight or obesity.

STEP 1 a 68-week safety and efficacy trial of sc semaglutide 2.4 mg versus placebo in 1,961 adults with obesity or overweight. The results were reported on 4 June.

STEP 2 a 68-week safety and efficacy trial of sc semaglutide 2.4 mg versus placebo and once-weekly sc semaglutide 1.0 mg once-weekly in 1,210 adults with type 2 diabetes and either obesity or overweight.

STEP 3 a 68-week safety and efficacy trial of sc semaglutide 2.4 mg versus placebo in combination with intensive behavioural treatment in 611 adults with obesity or overweight.

STEP 4 a 68-week safety and efficacy trial of sc semaglutide 2.4 mg versus placebo in 803 adults with obesity or overweight who have reached the target dose of 2.4 mg after a 20-week run-in. The results were reported on 13 May.

About Novo Nordisk Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 43,100 people in 80 countries and markets its products in around 170 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com, Facebook, Twitter, LinkedIn, YouTube.

SOURCE: Novo Nordisk

Originally posted here:
Semaglutide 2.4 mg shows superior weight loss versus placebo in the phase 3 trials STEP 2 and STEP 3, thereby successfully completing the programme |...

After Wall Street stocks on Thursday were convulsed by the biggest selloff since March, dazed analysts scrambled for answers, pointing the finger at the euphoria-driven buying seen among retail investors.

But Charlie McElligott, cross-asset strategist at Nomura, says a bigger culprit for why the S&P 500 index experienced a near 6% drop on Thursday was trading by options dealers that had to sell regardless of where they thought equities were headed.

On Thursday, the S&P 500 SPX, +1.30%, Dow Jones Industrial Average DJIA, +1.90% and Nasdaq Composite COMP, +1.01% all booked their biggest daily loss since March 16.

McElligott told MarketWatch that worries about a revival of coronavirus infections in some U.S. states created a trigger for the slump in risk assets, but doesnt explain why stocks sold off so violently.

The worries about a second wave of the coronvirus epidemic was a reality check for investors in beaten-down cyclical stocks which were playing catch-up since last week after earlier failing to share in Wall Streets two month rally led by technology stocks. Investors had recently seen significant gains among companies with fragile balance sheets and even by those that had filed for bankruptcy.

See: In latest market rally, even companies filing for bankruptcy get love

In McElligotts telling, investors had reassessed their gains from these growth-sensitive stocks, with some selling their holdings to realize profits. This, in turn, led to margin calls among retail investors that were trading these shares with borrowed money.

Nobody believes in their heart of hearts that were entering a new secular regime of higher inflation and growth, he said, characterizing the recent rally in these cyclical stocks as more of a rebalancing than an outright rotation away from growth and defensive stocks which had benefited in the past couple of months while cyclical stocks suffered from depressed earnings.

But the selloff started to accelerate, especially towards the end of Thursdays close, once banks and dealers prominent in options trading started to drive the market.

Thats how you get these crazy exponential-looking moves, said McElligott.

It works like this.

Investors will buy put options to prevent losses or benefit from a market selloff, while banks and options dealers will sell the options, taking the other side of the trade. When stocks slump, the losses associated with these options will surge for the dealers who sold them, forcing them to sell stocks or stock-futures to hedge their losses.

On top of that, dealers want to sell the options before they expire, usually at the end of the week.

Thats what happened on Thursday, said McElligott, who says there was also price-insensitive selling from commodity trading advisors and other volatility-targeting traders who had to reduce their risk as market volatility surged.

To a certain extent, this risk-on pro-cyclical rally collapsed under its own weight, he said.

McElligott says low interest rates and enormous monetary stimulus deployed by central banks has created the tendency for stocks to steadily trend higher before crashing down violently.

The suppression of long-term interest rates tends to push investors out of low yielding government bonds into riskier assets, often bought with borrowed money, adding fuel to the equities rally. Meanwhile other traders sell derivatives that generate income if volatility remains low but who then need to hedge when stocks become volatile. Eventually, these short-volatility strategies become so large that when the pendulum swings the other way, they add fuel to sharp market reversals.

This is how you get these Minsky moment blowups. We have a pennies in front of steamrollers dynamic, he said, referring to the onset of a market crash driven by bullish speculators taking profits combined with options sellers unwinding positions.

The term Minsky Moment was popularized in 1998 by Paul McCulley of PIMCO fame while referring to the Asian and Russian debt crisis of 1997-1198, after economist Hyman Minsky described the tendency of markets to collapse when speculative activity has been fueled by excessive leverage.

Still, McElligott said there is a positive side. Much of the need to sell by these options desks and volatility-targeting investors had been washed out Thursday, allowing the U.S. stock market to stabilize on Friday.

Indeed, the S&P 500 and Dow are trading tentatively higher, with both up more than 1% as they look to claw back the previous sessions losses.

Read: Heres how the stock market tends to trade after brutal selloffs like Thursdays

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The market collapsed under its own weight, says Nomura quant guru to explain Wall Streets violent selloff on Thursday - MarketWatch

For most people, losing weight and keeping it off involves creating a long-term strategy. Thats because many things besides what you eat can affect the number you see on the scale. Food, health conditions, and even lifestyle factors (like stress and how much sleep you get) can make it harderor easierto lose weight. Juliana Simonetti, MD Endocrinology and Metabolism, General Surgery joined Good Things Utah to talk about the risk factors associated with COVID-19 and obesity.

We know that obesity is one of the risk factors for COVID infection. Those with excess weight, even at a younger age, are having a more severe disease and higher rates of death if they have obesity. It is thought that obesity causes our body to heighten inflammation and with the COVID infection this makes the inflammation worse causing the more severe symptoms.

We tend to eat more and crave foods that are higher in calories and carbs when we are stressed i.e. COVID-19. Those foods physically make us feel better by releasing dopamine into our brains (the feel-good hormone). The problem is, this doesnt last long and the more we have, the more we want. We also have easier access to food when we are working from home. To add to the issue, some are seeing a decrease in physical activity with gyms being closed and/or fear of exercising in public places.

Here are some health tips to follow during COVID-19:

The University of Utah Health has lots of tools to help with their Comprehensive Weight Management Program They have registered dietitians, exercise physiologists, psychologists, mindfulness classes, medical interventions with medications to suppress some hunger and cravings, and surgical interventions. Theirteam works together to create individualized plans for each patient.

Their new facility at Sugar House Health Center was built with patients in mind. It is easily accessible with ample parking, tons of gym equipment and technology to measure resting metabolic rate, a demo kitchen, and even ultrasound scanning to detect fatty liver.

Come visit the newSugar House Health Center to schedule an appointment by visiting the University of Utah Health Weight Management Program now.

This story contains sponsored content.

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Nonsurgical and surgical weight loss options available with University of Utah Health - ABC 4

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