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Oct 29

Get rid of belly fat and see a difference in just 4 weeks – the exercise you have to try – Express

Get rid of belly fat and see a difference in just 4 weeks - the exercise you have to try  Express

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Get rid of belly fat and see a difference in just 4 weeks - the exercise you have to try - Express


Oct 12

Can intermittent fasting or calorie restriction slow the aging process? – University of Alabama at Birmingham

UAB Nutrition researchers are investigating whether calorie restriction or intermittent fasting can slow the aging process.

Researchers at the University of Alabama at Birmingham are recruiting participants for a new study that investigates whether intermittent fasting or calorie restriction, i.e., losing weight, can slow the aging process and make people younger.

Courtney Peterson, Ph.D., associate professor in the Department of Nutrition Sciences and site lead investigator, says this is the largest study on record investigating the effects of intermittent fasting on aging.

With this study, we want to accomplish several goals find out how easy it is to stick to these two diets long term, how much we can slow aging and improve overall health, and finally whether we can on a molecular level, such as regenerate stem cells, which would be very exciting, Peterson said.

Along with the Pennington Biomedical Research Center, UAB is recruiting 50 participants for the six-month study. Participants are randomly assigned either a calorie restrictive diet, intermittent fasting or to continue their usual diet. Those who are selected for calorie restriction will lose weight by eating less, while those who fast intermittently will fast for 16 hours per day and eat dinner by 6 p.m. about six days per week, with one break day per week. The study provides intensive coaching and support to help participants successfully lose weight or practice intermittent fasting.

Eligible participants should be ages 25-45, take no medications, be healthy, and have a BMI between 22 and 30 kg/m2.

To learn more or apply to participate, call 205-934-1457 or visit pbrc.edudialhealthuab.

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Can intermittent fasting or calorie restriction slow the aging process? - University of Alabama at Birmingham


Oct 12

Exercise guru shares four effective ways to burn belly fat – crucial for weight loss – Express

Dean said: "Now youve got your workout routine sorted, dont feel like youre stuck with it forever. Whilst repetition can be positive during workouts, it can also grow tiresome when youre doing the same exercises over and over."

The fitness expert pointed out that if people are repeating the same workouts over and over, not only will their muscles not respond in the desired way but he urged them "not to be afraid to switch things up".

"Identify the exercises that are proving unexciting and replace them with new ones that you enjoy," he said.

"Finding exercises boring may also be a sign that theyre too easy for you, which in itself is a sign that your fitness levels are improving.

"Heres where working with a trainer can help, providing other options to always keep your training fresh, fun and challenging."

Joining a fitness class can be beneficial in many ways and can inject fun and socialisation into people's weight loss journeys.

READ MORE:Michael Mosley weight loss: Remove three foods to stay slim

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Exercise guru shares four effective ways to burn belly fat - crucial for weight loss - Express


Oct 12

Simple fun ways to shed that stubborn weight fast – Business Daily

Wellness & FitnessMonday October 10 2022

A session at Corporate Health Gym, Vision Plaza in Nairobi on October 8, 2022. PHOTO | JEFF ANGOTE | NMG

Aerobic exercises come in different forms and shapes from running, walking, jogging, swimming, and biking. Then there is step aerobics.

Step aerobics, however, is not your ordinary aerobics. It is a classic high-intensity cardio workout that involves stepping on and off cardio equipment.

Step aerobics trainer Philip Luchebeleli says steps aerobics is an intense entire-body cardiovascular workout involving using steps during training.

He explains that the workout comes in different forms and though intense, combines effectiveness and fun in the process.

If you want to shed fat fast, take up step aerobic exercises for weight loss. Step aerobics make it more effective and fun as it boosts mood and energy levels, he says.

Just like aerobic exercises, step aerobics is a great way to lose weight through burning calories, improving lung capacity, and increasing heart rate while also boosting metabolism and kick-starting the bodys normal rhythm and functioning.

This as the moves involved work on the legs, upper body, and core, building strength and flexibility in the process as well as improving a persons balance, coordination, and agility leading to improved overall fitness and individual's cardiovascular health.

One needs to be patient as there are moves and terms that one needs to master. If you are overweight, you have to gradually increase the duration of the sessions as you build your fitness, advises the trainer.

He says that step aerobics is becoming popular with fitness enthusiasts with beginner, intermediate and advanced classes made available to cater to all types of individuals.

A few years ago I used to have a few step classes but now I am being called to many gyms. I dont even have free days, says the trainer.

However, to maximise results, one has to be consistent because skipping any session will mean that an individual will have to start from zero on resumption.

The trainer adds that one therefore also has to be patient, focused and consistent to learn the moves and avoid getting injured.

Depending on an individuals objective, if you just want to keep fit then three times a week is fine but for losing weight five days in a week is recommended, says Luchebeleli.

Workout is only 30 percent of the work but food intake accounts for the rest. An individual should observe a clean diet and give him or herself between three and four months to start seeing results, he adds.

This involves standing in front of a step box and marching along with the music beats as one places the right foot on the step and then the left one.

V-Step For this, place a step box in front of you then place the right foot on the step box in a diagonal direction. Place the left foot on the step box in the left diagonal direction with the feet wider than shoulder-width apart. Place the right foot on the ground in its initial position and then the left foot.

Charleston Place the left foot on the step box in front of the right leg then lift the right foot off the floor, lean back a little, and kick the right leg. Place the right leg back on the floor and then place the left foot on the floor and repeat from step one.

Repeater This involves standing with your feet close together and then placing the left leg on the step box diagonally to the right. After, lift the right leg off the floor, bend the knees, and kick up but do not crunch. Place the right foot back on the floor. Then, place the left leg on the floor. Place the right leg on the step diagonally to the left before lifting the left leg off the floor, bend the knees, and kick it up.

Place a step box on your right then step on the step box from the right and get down on the left. Step on the box from the left and get down on the right 20 times.

Begin standing sideways to the step, step up with the right foot and then turn as you bring the left foot up onto the step. Step down with the right foot and bring the left foot down to meet the right.

While performing the moves, Mr Luchebeleli advises that a person should maintain good posture and alignment by gently engaging the abdominals and gluteal muscles.

One should also not use slippery step surfaces, adjust the height of the steps depending on the level of fitness and skills, step softly and take small steps not more than one shoe length away from the platform.

He further recommends that one should get the right sports shoes as there are specific shoes for step aerobics where the soles have to be very soft so that when stepping they can bounce up and down.

The trainer says that the way one steps is key, advising that while stepping up, only the ankles and not the waist should bend and the entire foot should be placed on the step without any part hanging over the edge.

The tempo of the music you are using should not be very fast as one can run the risk of missing the steps and falling hence injuries. In class, do not depend on your neighbor by copying what they are doing. Focus on the trainer and do what the trainer is doing.

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Simple fun ways to shed that stubborn weight fast - Business Daily


Oct 12

Dwayne ‘The Rock’ Johnson was ordered to lose weight and change name for Hollywood career – Yakima Herald-Republic

Dwayne 'The Rock' Johnson was ordered to lose weight, drop his stage name and stop talking about wrestling if he wanted to make it in Hollywood.

The 'Fast and the Furious' star shot to fame back in the mid-1990s as a regular performer with the World Wrestling Federation (WWF) - adopting the name The Rock and becoming one of the franchise's most recognisable wrestlers before making a crossover to movies with a role as the Scorpion King in 2001's 'The Mummy Returns'.

However, Johnson has now revealed he was asked to make some serious changes if he wanted to be taken seriously as an actor. Speaking on 'CBS Sunday Morning' on October 9, he explained: "They said, 'Okay, great. But now here's what you have to do: You have to stop working out as much. You have to lose weight. You can't call yourself The Rock. You can't talk about wrestling. Let's stay away from all that.'"

Host Tracy Smith then asked him: "These are all the things they told you? 'Don't be this anymore'?" and the star replied: "That's right. So, I tried that, Tracy, I tried getting smaller, losing weight. It all felt wrong."

Tracy then asked: "And once you started being yourself?" and he explained: "That was it. When that happened, a funny thing happened: Hollywood conformed around me. And years later, I'm sitting here with you."

Johnson went on to land his first leading role, reprising his Scorpion King character for a self-titled 2002 spin-off and his Hollywood career took off. He eventually scored a lucrative recurring role in the 'Fast and The Furious' franchise as well as leading the cast of action movies such as 'San Andreas' and 'Skyscraper'.

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Dwayne 'The Rock' Johnson was ordered to lose weight and change name for Hollywood career - Yakima Herald-Republic


Oct 4

America, you’re fat. Here are 3 reasons why and what can we do to lose weight – Courier Journal

Bryant Stamford| Special to the Courier Journal

There is no delicate way to put it. Americans are fat and getting fatter every year.

Currently, 38% of men and 41% of women are obese, numbers that have doubled over the past three decades, and worse, the number of fat children and teens has tripled. But, why are we so fat?

The simple explanation is that we eat more calories than we burn each day, leading to an excess of calories in the body that are converted to fat and stored.

An argument can be made that this is not entirely our fault as we have fallen victim to lifestyle trends that sneaked up on us, and this is especially true for our children. For example, consider the role of our school systems. Kids expend fewer calories each day because of a reduction in physical education classes and recess, and less participation in organized sports. In addition, to boost revenue, many school systems have contracts with soft drink and fast-food companies, encouraging unhealthy and fat-promoting eating practices at school.

Add to all this the fact that at home, kids are playing video games or engaging in social media, instead of going outside to play. And, of course, adults move less as well, with space-age appliances, multiple car families, and too much TV, plus working more to pay for the high cost of living.

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Other behind-the-scenes trends have been operating as well, including high fructose corn syrup resulting in more calorically dense soft drinks, snacks and convenience foods. The fast-food industry also was hard at work contributing to American fatness. First was the introduction of "value meals," which combined sugary soft drinks with high-fat French fries and burgers. Soft drinks cause a big insulin response while fries and burgers provide lots of dietary fat calories. Insulin not only regulates blood sugar, but it also promotes the conversion of excess calories into body fat.

Another problem with fast food was the introduction of "supersizing" as the portion of French fries was greatly increased, tripling the number of calories per serving.

At the same time, busy Americans had less time to cook wholesome meals at home, and the frequency of eating out doubled in recent years. Eating out typically results in eating more than you do at home. Not only is volume increased, but restaurants need to appeal to our taste buds to draw us in, which means more emphasis on fat and sugar.

So, what can we do about it?

The American lifestyle combined with our genetic inheritance is the perfect storm when it comes to promoting body fatness. Genetically, we are programmed to survive, and in order to survive, we must have an ongoing supply of energy. No problem, right?

Certainly not in today's society with a fast-food restaurant on every corner. Unfortunately, our genes don't take into account our current ready availability of food. On the contrary, we evolved from early man when eating was unpredictable, and that fact combined with our drive to survive has shaped our behavior in a number of ways, starting with hunger, our strongest drive.

If we are denied food for a prolonged period, the hunger drive is so strong we will do almost anything to assuage it. For example, early man had to be driven hard by hunger every day to put forth the extreme effort required to procure food to feed a family. Now, fast forward to today and imagine being hungry and walking into a fast-food restaurant. Compared to early man, there's no effort involved in getting food, plus there are no limits. As a result, we regularly overeat far more than the body needs.

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Worse, it feels natural, and it is.

When our ancestors selected foods to eat, their choices were limited. If they ate meat, it was wild game, lean and tough and low in fat and calories. The things they could gather or grow, nuts, roots, fruits and vegetables, also were very low in calories. That means they had to eat a lot in order to take in enough energy to survive. This combined with the strong hunger drive and the unreliability of food, caused them to eat as much as possible any time they had the chance.

Fast forward to today, and it's no wonder we find ourselves eating large portions and seeking out all-you-can-eat restaurants. In fact, lack of portion control is a huge factor in obesity, especially with high-calorie foods. Sound familiar?

Sure, because it feels natural, and it is.

When we consume too many calories, our bodies are programmed to take the excess energy and store it in the form of body fat. This, too, makes sense to the body, because carrying around a bunch of extra stored energy in the form of fat takes some of the pressure off needing to consistently find and consume calories in order to survive. If you can't eat for a while, a common occurrence for our ancestors, you can simply tap into the energy you have stored as fat.

This is why your body loves every ounce of fat you have on you, and it always wants more, because more fat means more energy and more energy boosts the odds of survival or, at least it did way back then. Today all this excess fat is killing us, and the fact that our body loves fat helps explains why it is so reluctant to shed fat and keep it off.

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The bottom line is the deck is stacked against us when it comes to weight management. Our lifestyle combined with our genetic programming conspire to make us fat. Ironically, it all feels quite natural, and it is. This doesnt mean its impossible to buck the odds. Not at all. But it takes considerable dedication and effort, plus you cannot let your guard down.

Let me add that the worst mistake you can make is to allow yourself to gain body fat with the thought that you will take it off later. Its much easier to prevent gaining fat than it is to lose it.

Reach Bryant Stamford, a professor of kinesiology and integrative physiology at Hanover College, at stamford@hanover.edu.

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America, you're fat. Here are 3 reasons why and what can we do to lose weight - Courier Journal


Oct 4

5 Little-known Habits That Shrink Your Leg Fat, Expert Reveals Eat This Not That – Eat This, Not That

If you have unwanted fat around your legs, there's no time better than the present to do something about it. Luckily, you can often implement some simple habits that can help you shrink your leg fat without becoming a full-time athlete!

Lower-body fat in general can really sneak up on you. According to Livestrong, consuming an additional 100 calories each day can result in 10 additional pounds in a year. Unfortunately, females typically find the extra weight goes to their thighs, hips, and buttocks. To help you address this area, I've come up with some simple tips you can apply to your healthy lifestyle that can make a huge difference in your health and more-rapidly reduce your body fat burning. Taking on these habits will ultimately result in decreased fat around your legs.

You've heard this one before, but for good reason. Eating fewer calories than you burn is by far the fastest and easiest way to lose fat. It's true that you can't spot-reduce fat. So if you're noticing unwanted tissue in your lower body, the best thing to do is start eating a little bit less. Try dropping your calories by about 200 or 300 until you start noticing a difference. Don't go crazy; you definitely don't want to starve yourself.

The overall reduction in body fat will occur by burning fat from a variety of places on your body, depending on your genetics and body type. If you are losing weight but not seeing if come off your legs, be patient! You are likely improving another area, and eventually, your body will burn the leg fat, too.

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Don't underestimate the power of hydration if you want to shrink your leg fat. Just one glass of water here and there will help curb your hunger, improve digestion, and help shed extra weight. The more you can make this a habitual habit, the easier it will be until you reach the point where you don't even think about it. Carrying a gallon jug filled with water may be the key if you're always on the go. So drink up!

Hiking hills is one of the best ways to sculpt muscle and build up strength in your legs without beating up your joints or lifting weights. This is especially true if you carry a backpack. Just remember to be careful when coming back down the hill.

If you go hiking every weekend, you will start to notice an improvement in the look of your legs and your cardiorespiratory system. You'll breathe better, which means a longer lifespan. Plus, you'll develop the ability to push yourself in the gym and beyond.

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It's been proven time and time again that missing even a few hours of sleep over time can negatively affect your body. The lack of quality Z's can lower your ability to ward off disease and increase your craving for junk food.6254a4d1642c605c54bf1cab17d50f1e

In addition, soaking up some sunlight early in the morning helps set your circadian rhythm for the day and will increase your energy and vitality. Sit outside in the morning with a cup of coffee, and turn off all lights at least half an hour before you go to bed at night. These habits will make it easier to get a good night's rest.

Going out for a 10-minute walk after every meal will help you get your step count for the day and improve your ability to digest the food you just ate. Do this every time you eat, and it will have a huge overall impact on your weight loss due to increased activity levels. It only takes 10 minutes, so it's some quick healthy goodness to give yourself.

Tyler Read

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5 Little-known Habits That Shrink Your Leg Fat, Expert Reveals Eat This Not That - Eat This, Not That


Oct 4

You Can Reverse High Cholesterol "Fast" and Here’s How Eat This Not That – Eat This, Not That

According to the CDC, 94 million Americans are living with high cholesterol. "There are ways to manage high cholesterol, and the wonderful news is that heart disease is 90% preventable," says preventative cardiologist Leslie Cho, MD. "Even if you have a significant family history of high cholesterol, you can prevent heart disease." Here are five ways to reverse bad cholesterol, fast. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Avoiding saturated and trans fats can help lower cholesterol. "You can lower your cholesterol by limiting the type of foods you eat," says Dr. Cho. "This means becoming a food label reader. There should be no more than 2 grams of fat per serving, and it should account for less than 7% of your daily calorie intake. Trans fats have a very negative impact on the body. Not only do they worsen your cholesterol, but they also increase your markers of inflammation." This can lead to inflamed blood vessels, a risk factor for heart attacks."

Belly fat is strongly linked to high cholesterol. "Importantly, central obesity is a marker for increased inflammation within the body, which can result in cholesterol buildup in your blood vessels," says Joshua Septimus, MD, associate professor of clinical medicine and medical director of Houston Methodist Primary Care Group Same Day Clinics. "It's also a marker for unstable plaque. Remember, once plaque becomes unstable, the risk of stroke and heart attack increase."

Losing weight can have a significant impact on cholesterol levels, doctors say. "If you lose even a small amount of weight, your HDL will go up and your LDL will come down," says Dr. Cho. "Losing five to 10 pounds can lower your total cholesterol by 5% to 10%."

Not smoking can positively impact cholesterol levels, doctors say. "Smoking causes inflammation and damage to your blood vessels, leading to unstable cholesterol plaque and, ultimately, increases your risk of plaque rupture," says Dr. Septimus.

Regular exercise is key to lowering cholesterol and keeping it down. "Exercise is a great place to start if you're trying to lower bad cholesterol," says Dr. Cho. "But it doesn't stop there. Combining exercise with healthier diet and lifestyle choices makes the most impact. Always check with your doctor before starting an exercise program, especially if your high cholesterol is putting you at more immediate risk for heart disease or stroke,"6254a4d1642c605c54bf1cab17d50f1e

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You Can Reverse High Cholesterol "Fast" and Here's How Eat This Not That - Eat This, Not That


Oct 4

‘There’s no way that patients are going to be able to afford that.’ Why aren’t new drugs that can help you lose weight more widely used? – Morningstar

Jaimy Lee

A decades-old law is keeping older adults in the U.S. from trying new weight-management therapies like Wegovy -- and drug companies are paying millions of dollars to try to get it changed.

A pair of new drugs offer something many Americans desperately want: a way to lose weight.

In clinical trials, Novo Nordisk's Wegovy helped adults lose about 15% of their body weight. The drug, which received approval from the U.S. Food and Drug Administration last year, had such a successful launch that it's now in short supply. Eli Lilly's (LLY) tirzepatide, meanwhile, is still in clinical trials, but data from a Phase 3 trial showed that people taking the drug lost up to 22% of their body weight.

For the roughly 42% of Americans who are obese, these results are nothing short of a miracle.

Wall Street is thrilled, predicting a global market for the drugs as big as $54 billion by 2030. And physicians feel they finally have a new treatment option for their patients. "I was prescribing Wegovy almost as fast as I could," said Elizabeth Fryoux, a physician who practices obesity medicine at the University of Mississippi Medical Center.

And there is more research coming: Lilly and Novo are also running studies to figure out if the same drugs can reduce the risk of death or improve outcomes for conditions like high blood pressure and stroke that often go hand in hand with obesity.

But there are roadblocks to getting these therapies to patients who need them. Late last year, Wegovy ran into supply issues brought on by a combination of high demand and production issues involving the syringes used in the pens that inject the medication. The issues are expected to resolve sometime beforethe end of the year. The stigma surrounding obesity, meanwhile, may be discouraging insurers and policymakers from covering these drugs.

The drugs developed by Novo and Lilly to treat obesity have both been approved, in different formulations, to treat Type 2 diabetes. Those therapies -- Novo's Ozempic and Lilly's Mounjaro, which got FDA approval in May -- are covered by Medicare, the federal health-insurance program for older adults and people with disabilities. Medicare doesn't cover Wegovy or other FDA-approved weight-management therapies, including Vivus' Qsymia.

"If we have a drug that is Wegovy that is for weight loss, and it's not covered, but we have a drug that is Ozempic, and it's for diabetes, the exact same drug is covered," said Holly Lofton, a physician who works in obesity medicine at NYU Langone Health in New York City. "There's not a drug issue. There's a 'we don't want to treat this patient' issue. That comes from stigma or discrimination or lack of knowledge about obesity as a condition."

A decades-old law prohibits Medicare from covering prescription drugs to treat weight gain or weight loss. That means the roughly 49 million people in the U.S. who get their prescription drug coverage from Medicare would have to spend more than $1,300 a month for a Wegovy prescription, putting access far out of reach for many. Even for people with private health insurance, these drugs may not be covered. Less than 10% of people have commercial health insurance that covers weight-management therapies like Wegovy.

But an aggressive lobbying push in Washington and quiet support in different parts of the Biden administration indicate that the longstanding rule is being reconsidered. The House Appropriations Committee in June described Medicare coverage for obesity drugs as a "matter of health equity." The Office of Personnel Management, the federal government's human resources department, this year reiterated that obesity drugs can't be excluded from insurance plans for federal workers. "The bottom line is that we follow the science and, in this instance, the science is telling us that we should recommend uptake of anti-obesity drugs more strongly than we did previously," an OPM spokesperson told MarketWatch.

This line of thinking suggests that "additional federal coverage may not be far behind," said UBS analyst Colin Bristow.

Ted Kyle runs ConscienHealth, an obesity advocacy organization. "That momentum comes from people having a better understanding of what we're dealing with," he said. "Ten years ago, policymakers would come out and say, 'Fat people need to eat less and move more.'"

A vanity drug or an outdated policy?

Until recently, the medical community often blamed obesity on a lack of willpower or a mismatch between calories consumed and calories burned. The American Medical Association now considers obesity a disease, and doctors describe patients as having overweight or obesity, not as being overweight and obese, and refer to weight management, not weight loss.

But that shift in thinking is still relatively new -- the American Board of Obesity Medicine, which certifies physicians who work in this field, was set up in 2011 -- and challenges remain. A story published last spring in The New York Times reported that a health insurer had declined to cover Wegovy for a patient on the grounds that it's a "vanity drug."

"That feels so stigmatizing," said Diana Thiara, medical director of the University of California San Francisco's weight management program.

The Medicare ban on covering weight-loss drugs, which was part of the implementation of the Medicare Part D program in 2003, likely results from that same stigma. It also followed the fenfluramine phentermine ("fen-phen") crisis of the late 1990s, in which the stimulants fenfluramine and dexfenfluramine, prescribed for short-term use for weight loss, were pulled from the market when it was discovered they could cause heart-valve damage that in some cases resulted in death.

The newest class of weight-management drugs -- as well as therapies like Qsymia and Currax Pharmaceuticals' Contrave, which were approved about a decade ago -- are not stimulants. Wegovy, which is the first new weight-management drug to have been approved since 2014, is a glucagon-like peptide-1 (GLP-1) agonist, while tirzepatide is a GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist. When paired with physical activity and calorie reduction, they help slow digestion and increase the release of insulin so that patients end up feeling full faster and for longer.

"These actually are now very physiologic," Lofton said. "Most of them [are] hormones that we're giving people to adjust their gut and brain pathways to send different messages about hunger and fullness and desire to eat."

Medicare does pay for bariatric surgery and behavioral weight-loss therapy. Over the years, legislative fixes to the medication ban have been proposed, including the Treat and Reduce Obesity Act, which has been introduced several times over the past decade, most recently in March of 2021. Lilly and Novo are both lobbying to change the Medicare language, and physicians, including NYU's Lofton, have also been calling on lawmakers to do so.

So far, those efforts have not been successful.

"Medicare is behind the times, and it's hampered by its own outdated policies," said Dorothea Vafiadis, director of the National Council on Aging's Center for Healthy Aging. "If you look at the CMS stated commitment, they are designed to close gaps in healthcare access, quality, and outcomes for underserved populations. And this really kind of flies in the face of that commitment."

The National Council on Aging, along with obesity advocacy organizations such as the Obesity Action Coalition, receive funding from the drug companies that market or are developing weight-management therapies. So do Kyle and Lofton, among other physicians and advocates. These financial relationships, though common in U.S. medicine and public policy, also underscore the billions of dollars in sales that may be at stake for Lilly and Novo.

A $54 billion market

Companies are racing not only to develop the most effective weight-management drug but to market the one that can best improve outcomes for obese patients beyond losing weight.

Novo expects to have the first batch of data from its Phase 3 clinical trial -- which will show whether Wegovy can reduce the risk of heart disease and stroke -- by mid-2023, according to a spokesperson. (The company also makes Saxenda, an older weight-management drug that's been shown to reduce body weight by about 5%.) Lilly, which is expected to soon file for FDA approval of tirzepatide as a weight-management therapy, also plans to launch a Phase 3 trial later this year to evaluate whether its drug can reduce morbidity and mortality.

If either study shows positive results, it could change the conversation with insurers and employers, because the value of an individual patient taking one of these medications will then be twofold. Not only will patients lose weight, but their comorbidities may improve, possibly averting costly medical care down the line.

Morgan Stanley predicts an obesity-drug market as large as $54 billion by 2030. UBS predicts $25 billion in peak sales for tirzepatide, which would make it "one of the bestselling drugs in history," according to the bank's analysts. SVB Securities puts peak sales expectations for tirzepatide, taking into account its potential use for both diabetes and obesity, a little lower, at roughly $21 billion. For context, Humira, AbbVie's rheumatoid-arthritis drug, is the world's top-selling drug, generating $20.7 billion in annual sales in 2021.

"Historically, [insurance] payers viewed obesity drugs like they did Botox for wrinkles. They viewed it as something that was a cosmetic drug that should not be covered by insurance," said David Risinger, an SVB analyst. "There needs to be a rethinking of coverage when there are drugs that offer transformational health benefits for a disease, even if it's common."

If that's the case, think of these drugs less like Botox and more like a new knee.

(MORE TO FOLLOW) Dow Jones Newswires

10-03-22 1649ET

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'There's no way that patients are going to be able to afford that.' Why aren't new drugs that can help you lose weight more widely used? - Morningstar


Oct 4

Diets to Help You Lower Your Cholesterol and Lose Weight – Healthline

If you have hypercholesterolemia, or high cholesterol, and are considering the best diet to lose weight and manage your condition, youre far from alone.

The Centers for Disease Control and Prevention (CDC) reports that 94 million adults in the United States over the age of 20 have borderline high or high cholesterol. Cholesterol can build up in your arteries, narrowing or stopping the flow of blood, and potentially causing a heart attack or stroke.

If you have high cholesterol, your healthcare team has likely recommended that you control your cholesterol level with lifestyle changes. These include getting more exercise and tweaking your diet or losing weight if youre overweight or have obesity.

With so many weight loss diets trending, it may be hard to choose among a multitude of popular or highly publicized options. One of the most common bits of advice is to choose the diet you can stick with, but theres a caveat. Some diet plans are more likely to lower your cholesterol, while others can make it worse.

Lets look at which dietary choices can help you lower your cholesterol and which wont.

When choosing an eating plan, its helpful to know which foods can be helpful in weight and cholesterol management. The American Heart Association (AHA) recommends the following foods as the basis for a heart-healthy diet:

Foods that can increase your cholesterol and contribute to weight gain include:

Its nice to have general recommendations, but many people prefer to have a clearer plan to follow.

If youre one of those people, here are some of the best research-backed, heart-healthy diets. These diets also boast a higher-than-average adherence rate. Thats how likely you are to stick to them in the long term.

The Mediterranean diet is tops on most lists and has the most research backing it. It includes:

The Dietary Approaches to Stop Hypertension (DASH) diet was crafted specifically to stop high blood pressure. Its part of a plan that also includes exercise. But, its also proven to reduce cholesterol.

The recommendation is to eat a diet rich in:

The DASH diet also calls for reducing total fat, especially saturated fat.

The National Institutes of Health developed the Therapeutic Lifestyle Changes (TLC) diet to reduce your risk of heart attack and stroke. It includes eating based on certain numeric guidelines and getting 30 minutes a day of physical activity most days of the week. Key dietary recommendations are:

The Dean Ornish diet is a low fat, lacto-ovo-vegetarian diet. That means you avoid eating meat from animals, but you can have milk and egg products. In this case, it allows for egg whites and nonfat dairy.

This diet emphasizes eating mostly plants in their natural forms. You get most of your protein from plant sources, such as tofu, beans, and tempeh. It also emphasizes whole grains and healthy fats, and limits simple carbohydrates, especially sugar.

Though there isnt much new research available, an older 2009 study found that the Ornish diet was effective at reducing total cholesterol, LDL cholesterol, and triglycerides.

The Flexitarian diet has become more popular over the years. Its a popular choice for some people who tried going fully vegetarian or vegan but may have found that eating plan too hard to stick to, or wanted some animal foods in their diets.

A 2015 study found that people who occasionally strayed from a vegetarian or vegan diet had significantly reduced their cholesterol and lost weight. A 2017 review also found that a Flexitarian diet improved metabolic health and blood pressure, and reduced the risk of diabetes.

The Flexitarian diet has no rigid rules, just lifestyle recommendations:

The vegan diet has become one of the most hyped eating plans, followed by an ever-lengthening list of celebrities. It calls for cutting out all animal products. This can reduce cholesterol greatly, as long as you stick to:

A 2018 study concluded that, in most countries, a vegan diet can significantly reduce LDL cholesterol and triglycerides. The study also showed reductions in body mass index (BMI), waist size, blood sugar, and blood pressure.

Some studies suggest that low carb diets raise your LDL cholesterol levels. But the South Beach Diet claims to do just the opposite. An older study found that the South Beach Diet did reduce LDL and total cholesterol.

The South Beach diet doesnt call for totally eliminating carbs, but rather choosing those with a low glycemic index. Its a phased program that initially calls for cutting out carbs, then reintroducing them a little at a time.

The diets effect on your cholesterol level depends on the types of protein and fat you choose to eat. The South Beach meal plan reduces your intake of saturated fats, which should lower your LDL cholesterol.

Some diets stand out as being risky for heart health. Some of these are based on a popular low carb and high protein way of eating. While they may be effective for weight loss, they allow or recommend a high intake of foods known to raise cholesterol levels.

Some popular diets that recommend this approach may lead to weight loss but higher cholesterol. According to the AHA, some have been linked to early death. It all depends on the types of fat and carbohydrate you consume.

Some diets that can contribute to higher cholesterol include:

The ketogenic (keto) diet involves whittling down your total carbohydrate intake to 20 to 50 grams per day. You get the bulk of your nutrients from protein and fats to force your body to use ketones instead of glucose (a kind of sugar) for fuel.

The keto diet can be safe and healthy for many people. But for others, it may worsen high cholesterol. This is especially true if you have familial hypercholesterolemia.

The keto diet can especially raise cholesterol if you get your calories from processed foods and saturated fats. These are present in fatty cuts of meat and whole milk dairy and cheese.

The Atkins diet entails eating all the protein and fat you want as long as you avoid high carb foods. Because it creates a calorie deficit, its effective for weight loss. But it also has the potential to include very high levels of saturated fat and processed meat, such as hot dogs and bacon.

A small 2018 study found a 44% increase in LDL cholesterol over 3 weeks in young, healthy adults on the Atkins diet compared to those who continued with their regular eating habits.

If you have high cholesterol or are at high risk of developing it, your doctor will first recommend lifestyle and dietary changes. Because there are so many popular diets, it can be hard to choose the right one for you.

Several diets have stood the test of time when it comes to lowering cholesterol. These include the Mediterranean Diet, the DASH diet, and the TLC diet. Plant-based diets like vegan and vegetarian diets can also help lower cholesterol.

Diets to avoid include high protein, low carb diets. Although these diets help many people lose weight, some of them call for unlimited consumption of foods that raise cholesterol, including red meat, fatty meat, and whole fat dairy.

Picking a diet you can stick to is the key to long-term success, so long as its heart-healthy. If youre unsure about which diet to choose, talk with your healthcare team.

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Diets to Help You Lower Your Cholesterol and Lose Weight - Healthline



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