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Now, research highlights a discovery that could pave the way for a new class of weight loss medicationsand its linked to how your body responds to exercise. Heres what the study discovered, plus what it could mean for the future of drugs like Ozempic.

Meet the expert: Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California.

The study, which was published in June in the journal Molecular Metabolism, analyzed mouse and human models to explore how the protein PGC-1 impacts exercise and its effects on the body. In case you're not familiar with it (and why would you be?), PGC-1 is a protein that is involved in several processes in the body, including thermogenesis. Thermogenesis works to help your body efficiently consume energy in your muscles.

When you work out, more PGC-1 is expressed in your muscles and more energy is burned. But people who lose weight slowly when they do regular physical activity may be missing variants of PGC-1 that regulate the bodys metabolism and response to short-term exercise.

By targeting this protein, scientists think they can essentially help to rev up your metabolism. The researchers concluded in the study that increasing how much PGC-1 is expressed is pivotal for burning more energy and essential for regulating metabolism.

At this point, its hard to say. The scientists just discovered that it could be helpful to target this protein for weight loss, but the details and kinks of this havent been worked out just yet.

But it's possible that people who already burn fat efficiently with the help of exercise wouldnt be helped by a medication that targets PGC-1, says Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California. Still, it's super early on in the process, making it tough to determine for sure.

Its not clear at this point. Again, this is in very early stages and theres a lot that still needs to be explored. However, there is a chance that this could lead to a new class of weight loss drugs, giving people with overweight and obesity more options, Ali says.

Right now, Ali sees this as a potential additional tool to help with weight loss versus the only tool someone would use.

The majority of weight loss is because of diet, he says. Exercise has a number of benefits, including enhanced weight loss, and it can improve cardiovascular health.

If theres a medication that could enhance how well you burn fat through exercise, that would be an additional tool to use, Ali says. But, he adds, were a long way from that.

Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Mens Health, Womens Health, Self, Glamour, and more. She has a masters degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.

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Scientists Just Made A Major Genetic Discovery That Could Lead To The Next Ozempic - Women's Health

The founder of 'Blue Zones' Dan Buettner has shared ten ingredients that could help you "live longer, lose weight and feel better".

The National Geographic fellow and author, 64, recently took to his Instagram platform to explain the benefits of the "purest form of the Meditteranean diet".

In recent years, Buettner has become well known for his studies into the world's "Blue Zones" - areas of our planet where people typically lead longer lives.

The explorer and educator researches every possible aspect of these regions from diets and exercise to the impact of religion and our relationships.

One of these zones is the Greek island of Icaria (or Ikaria) in the Aegean Sea.

Speaking to his followers in front of a table filled with popular Icarian ingredients, Buettner explained that the ten foods "represent a thousand years of culinary genius."

"This is the traditional Icarian diet, most of the ingredients have been around for 60, 70, 100 years."

"You can take every one of these ingredients in every one of these dishes and trace it back to the evidence showing why it helps you live longer, and lose weight and feel better."

The author also praises how inexpensive the ingredients are as well and that you can eat them your whole life.

So, what are these ingredients? Let's take a look.

Buettner starts with one of his most recommended foods - beans.

In his social media post be explains that beans particularly chickpeas and black-eyed peas, are eaten like a snack or added to soups and stews.

Buettner admits that chickpeas maybe high in fat butnearly all of it is unsaturated.

The second food found in the Icarian diet that Buettner suggests adding to our own is Fennel.

From bulb to seeds, the explorer says that Fennel"is packed with nutrients, including calcium, iron, manganese, and potassium".

Icarians use it in their cooking as well as in herbal teas.

Buettner also suggests adding wild greens into our routines through the likes ofpurslane, dandelion, and arugula.

The expert explains that they area "great source of minerals as well as carotenoids"

Carotenoids are the colourful pigments the body converts to vitamin A.

Lemons are also eaten whole - the skin and all - in Icaria.

The lemonpeel may have a beneficial impact on blood glucose which helpsto control or prevent diabetes.

Buettner also pointed his followers towards olive oil which he says Ikarians eat at least four tablespoons worth a day.

The explorer notes that olive oilmay protect against heart disease before adding thatits also why one study suggests Ikarians have a 50%lower mortality rate.

Other ingredients in the Icarian diet with longevity benefits include the herbs Oregano, Rosemary andSage.

Buettner explained: "Oregano is one of the many herbs used in Icarian cooking. Its rich in antioxidants and compounds proved to help fight bacteria".

Talking about Sage, the expert says having the herb in their diets "could beone of the reasons Ikarians have lower rates of Alzheimers and dementia".

Sage is also said to have propertiesthat help strengthen bones.

Meanwhile, Rosemary isshown to improve digestion and enhance memory and isused quite often in herbal teas throughout Ikaria.

Additionally, Buettner says that potatoesare eaten daily in Icaria.

This isn't the case in other Mediterranean diets.

However, the explorer points to studies that suggest potatoes can reduce blood pressure, fight diabetes, and prevent inflammation.

Lastly, Buettner concludes by recommending honey since the islanders use it "to treateverything from colds to wounds".

He added: "Besides stirring it into coffee, older Ikarians also take a spoonful in the morning and before dinner".

Continued here:
10 foods that will help you 'live longer, lose weight and feel better' - Yahoo News UK

Ozempic (semaglutide), Wegovy (semaglutide), and Mounjaro (tirzepatide) are medications that can help lower blood sugar in people with diabetes or hyperglycemia (high blood sugar). All three medications belong to a class of drugs called glucagon-like peptide-1 receptor agonists, concisely known as GLP-1s.

While the U.S. Food and Drug Administration (FDA) has only approved Wegovy as a weight loss drug, other GLP-1s offer possible weight loss benefits.

In your body, the GLP-1 hormone helps release insulina hormone that helps move glucose (sugar) from the blood into other areas of the body, where it can be used for energy. GLP-1 also helps to regulate the amount of glucose the liver makes by decreasing glucagon (a hormone your pancreas makes).

In people who are overweight or obese, the amount of GLP-1 hormone in the body is lower than usual. Therefore, providing the body with more GLP-1 may help you lose excess weight, if necessary. GLP-1 agonist medications are thought to help with weight loss in the following ways:

One study found that the average weight loss difference between people who received GLP-1s and those who received a placebo drug was 4% to 6.5% in people with type 2 diabetes and 6.1% to 17.4% in people without diabetes. Another study involving people with type 2 diabetes and obesity found that one-third of people in the study lost over 5% of their starting body weight after 72 weeks.

While Ozempic, Mounjaro, and Wegovy are all GLP-1 agonists, Mounjaro is also considered a glucose-dependent insulinotropic polypeptide (GIP) agonist. The GIP hormones work similarly to the GLP-1 hormone, helping to regulate the amount of insulin in the body and making you feel fuller quicker.

Which of these medications is best for weight loss?

Ozempic (semaglutide) is FDA-approved to help control blood sugar levels in people with type 2 diabetes. This medication can also help lower the risk of cardiovascular events like stroke or heart attack in people with type 2 diabetes and heart disease. Ozempic is a once-a-week injection that starts at 0.25 milligrams (mg) and can be further increased by 0.5 mg every four weeks until you reach 2 mg doses.

Ozempic is not FDA-approved for weight loss, though it may be prescribed by a healthcare provider off-label to help with weight loss. Off-label use means a medication is prescribed for a purpose other than what it is FDA-approved for, which is common in healthcare.

Ozempic contains the active ingredient semaglutide. Many researchers have utilized the 2.4 mg dosing of semaglutide for maximum weight loss benefits. However, the maximum recommended dose for Ozempic is 2 mg. Though this may be lower than the doses often studied, it is believed that Ozempic would still aid in weight management at 2 mg.

Wegovy (semaglutide) is FDA-approved to lower the risk of cardiovascular events like stroke or heart attack in people with obesity and underlying heart disease. Wegovy is also FDA-approved to help with weight loss in adults and children over 12 years old who are living with obesity.

The recommended starting dosage for Wegovy is 0.25 mg once a week. The dose can be increased every four weeks until the maximum dosage of 2.4 mg is reached.

Numerous studies have found that Wegovy supports weight loss, specifically when given at a higher dose of 2.4 mg once a week. These studies (called the STEP Trials) found that Wegovy led to significantly more weight loss (16% weight change) over 68 weeks compared to people taking a placebo drug (5.7% weight change).

Over two years, the average change in weight loss was 15.2% in those who received Wegovy versus 2.6% in people who received a placebo.

Mounjaro (tirzepatide) is FDA-approved to lower blood sugar levels in people with type 2 diabetes. Unlike Ozempic and Wegovy, Mounjaro works as both a GLP-1 and GIP agonist. Though not FDA-approved for weight loss, Mounjaro has been shown to help with weight loss in people with obesity.

The recommended starting dosage for Mounjaro is 2.5 mg once a week. After four weeks, the dose can be increased by 2.5 mg as needed. The maximum dosage is 15 mg once a week.

Mounjaro has been studied in people with type 2 diabetes in a group of studies called the SURPASS trials. One study (SURPASS-2) specifically compared Mounjaro 5 mg, 10 mg, and 15 mg to low-dose semaglutide (1 mg) in people with type 2 diabetes.

The following chart shows the average loss in body weight with Mounjaro after 40 weeks. Measurements are abbreviated as milligrams (mg), pounds (lbs), and kilograms (kgs).

When these dosages were compared to 1 mg of semaglutide, people using semaglutide lost an average of 12.6 pounds or 5.7 kilograms after 40 weeks. However, it's important to note that a 1 mg dose of semaglutide is lower than the recommended 2.4 mg dose for weight loss.

The average weight loss over 40 weeks in the SURPASS-5 study was slightly different from the findings in the SURPASS-2 study. Those on Mounjaro lost an average of 11.9 lbs (5.4 kgs) with a 5 mg dose, 16.5 lbs (7.5 kgs) with a 10 mg dose, and 19.4 lbs (8.8 kgs) with a 15 mg dose. People who took a placebo drug gained an average of 3.5 lbs (1.6 kgs).

Before you start taking medications, it's important to be aware of any possible side effects. While taking GLP-1s, you may experience the following:

While less common, more serious side effects of GLP-1s include:

Talk to your healthcare provider about your options if you're interested in GLP-1s to aid your weight loss journey. Your provider can help determine which GLP-1 medication would be best for you based on your medical history and treatment goals.

For example, Ozempic may be a better option if you have type 2 diabetes and heart disease. However, Wegovy may be better if you live with obesity. It's also important to factor in the cost of the GLP-1 medications for weight loss, as some may be covered by insurance, while others may not be.

Ozempic, Wegovy, and Mounjaro are GLP-1 medications that can help lower blood sugar in people with diabetes or hyperglycemia. These medications have become popular due to their potential weight loss benefits.

While Wegovy is the only medication FDA-approved for weight loss, all three medications can help you manage your weight. If you're interested in learning more about these medications, talk with your healthcare provider to see if you are a candidate to take these medications.

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Ozempic, Wegovy, or Mounjaro: Which Medication Is Better for Weight Loss? - Health.com

Key Takeaways

Eli Lilly (LLY) and Novo Nordisk (NVO) shares lost ground, while shares of drugmaker Viking Therapeutics (VKTX) soared in intraday trading Thursday after the company reported advances in trials of its weight-loss drugs that could challenge the dominance of Novo Nordisk's Wegovy and Eli Lilly's Mounjaro.

Viking Therapeutics said in its second-quarter earnings report Wednesday that the injectable and oral versions of its weight-loss drugs are expected to progress to further stages of trials in the second half of the year.

The latest phase 2 study for the injectable version of Viking's weight-loss drug showed some patients lost up to 15% of their baseline body weight over the course of a 13-week treatment period, Viking said. The company also said it expects to schedule a meeting with the Food and Drug Administration (FDA) about the study later this year, and organize a phase 3 trial following the meeting.

In a phase 1 trial for the oral version of the drug, patients lost up to just over 5% of their baseline body weight over a 28-day course of daily doses. Viking said it plans to schedule a phase 2 test for the oral version later this year.

The news sent shares of Viking up over 33% to $67.46 as of 1 p.m. ET Thursday, in the stock's latest boost from weight-loss drugs. The stock more than doubled in a single day in February following the results of a previous trial, and rose nearly 17% in one session in March after Viking disclosed the results of the first oral drug trial. Shares of Viking have more than tripled in value since the start of the year.

Meanwhile, while shares of competing weight-loss drugmakers Eli Lilly and Novo Nordisk fell Thursday. Surging demand for weight-loss drugs like Eli Lilly's Mounjaro and Novo Nordisk's Wegovy has boosted both the revenue and stock prices of the companies in recent quarters, with both working to increase production to be able to meet the demand.

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Why Vikings Weight-Loss Drug News Is Weighing on Eli Lilly, Novo Nordisk Stocks - Investopedia

Research on the gut microbiome has triggered a 'revolution' in nutritional science, and in the last few years, dietary fiber has become the "new protein" added to foods in abundance to feed our gut and boost our health.

A recent study on mice, however, suggests not all fiber supplements are equally beneficial.

A form that is readily found in oats and barley, called beta-glucan, can control blood sugar and assist in weight loss among mice fed a high-fat diet.

Researchers at the University of Arizona (UA) and the University of Vienna say it is the only type of fiber supplement they tested that decreased a mouse's fat content and body weight within 18 weeks.

The other fibers considered, including wheat dextrin, pectin, resistant starch, and cellulose, had no such effect, despite shifting the makeup of the mouse microbiome significantly compared to mice fed no fiber supplements.

"We know that fiber is important and beneficial; the problem is that there are so many different types of fiber," explains biomedical scientist Frank Duca from UA.

"We wanted to know what kind of fiber would be most beneficial for weight loss and improvements in glucose homeostasis so that we can inform the community, the consumer, and then also inform the agricultural industry."

Dietary fibers are the main source of energy for bacteria living in our guts, and yet less than 5 percent of people in the US consume the recommended 2530 grams (0.91 ounce) of fiber a day.

To make up for this, fiber supplements and 'invisible fiber'-infused foods are growing in popularity. But fibers are extremely diverse, so which do we choose?

Some fibers, like oat beta-glucans and wheat dextrin, are water-soluble, meaning they are easily fermented by gut bacteria. Others, like cellulose and resistant starch, are less soluble or insoluble, meaning they stick to other materials to form stool.

Until now, writes biomedical scientist Elizabeth Howard from UA and her colleagues, "there is no study that has investigated the role of various fibers in one cohort."

To make up for this, the current study tested several forms of fiber in one cohort of mice. Only beta-glucan was found to increase the number of Ileibacterium found in the mouse intestine. Other studies on mice have linked this bacterium to weight loss.

Sure enough, long before the 10-week marker, mice fed beta-glucan showed reduced body weight and body fat content compared to mice fed other forms of fiber.

The findings align with another recent study by Duca, which fed barley flour, rich in beta-glucan, to rodents. Even though the rats continued eating just as much of their high-fat diet as before, their energy expenditure increased and they lost weight anyway.

A similar outcome was observed in mice fed beta-glucan in the new study. These animals also showed increased concentrations of butyrate in their guts, which is a metabolite made when microbes break down fiber.

Butyrate induces the release of glucagon-like peptide-1 (GLP-1), which is the natural protein that synthetic drugs like Ozempic mimic to stimulate insulin release.

"Part of the benefits of consuming dietary fiber is through the release of GLP-1 and other gut peptides that regulate appetite and body weight," explains Duca.

"However, we don't think that's all of the effect. We think that there are other beneficial things that butyrate could be doing that are not gut peptide related, such as improving gut barrier health and targeting peripheral organs like the liver."

Far more research is needed before these results can be extended to humans, but the findings suggest that some fibers may be better suited to weight loss and insulin control than others.

The study was published in the Journal of Nutrition.

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One Type of Fiber Could Have Weight Loss Benefits Similar to Ozempic - ScienceAlert

In the 1980s, researchers identified a hormone in the human gut called GLP-1 that triggers the release of insulin, which controls blood sugar levels. The discovery would eventually launch a new class of diabetes drugs known as GLP-1 receptor agonists, the first of which was approved in 2005.

The drugs not only kept blood sugar in check. Curiously, they also seemed to suppress appetite, and some people taking them lost a modest amount of weight. The revelation led the US Food and Drug Administration to approve the first GLP-1 drug for weight loss in 2014. Called liraglutide and sold under the brand name Saxenda, the weekly injectable led to a nearly 3 percent reduction in body weight on average in trial participants who took it.

By then, Novo Nordisk, the maker of Saxenda, was already working on a better GLP-1. This new drug, semaglutide, was first approved for diabetes in 2017 under the brand name Ozempic and then in 2021 for weight loss as Wegovy. In trials of the drug, participants who received Wegovy lost around 15 percent of their initial body weighta total game changer.

Hot on the heels of semaglutide is Eli Lillys tirzepatide, approved as Mounjaro in 2022 for diabetes and as Zepbound in 2023 for weight management. In studies of Zepbound, patients taking the highest dose lost around 21 percent of their body weight. In a head-to-head comparison of Wegovy and Zepbound published earlier this month, Zepbound was found more likely to lead to significant weight loss.

These drugs are now wildly popular, in shortage as a result, and hugely profitable for the companies making them. Their success has sparked a frenzy among pharmaceutical companies looking for the next blockbuster weight-loss drug. Researchers are now racing to develop new anti-obesity medications that are more effective, more convenient, or produce fewer side effects than the ones currently on the market. The existing drugs can cause nausea, headaches, and other unpleasant side effects that lead some people to stop taking them.

They have other downsides too. In the United States, they can cost more than $1,000 a month and arent always covered by insurance. They have to be injected under the skin once a week. And while most people who stay on them see positive results, others dont lose much weight at all. Not to mention ongoing shortages of GLP-1s are making it hard for patients to start and continue taking them as prescribed.

Having more drugs on the market would mean more choices for patientsand more profits for the companies selling them. Its an extraordinarily exciting and busy time in the field of obesity, says Darren McGuire, a cardiologist and professor of internal medicine at University of Texas Southwestern Medical Center.

Semaglutide and tirzepatide work by activating GLP-1 receptors in the pancreas to stimulate the production of insulin, which helps to control blood sugar levels in people with type 2 diabetes. These drugs also slow down the emptying of the stomach and interact with GLP-1 receptors in the brain to tamp down hunger. As a result, people tend to eat less and have fewer food cravings while taking them.

Its possible that tirzepatide is slightly more effective because its a dual receptor agonist. In addition to GLP-1, it also activates receptors of GIP, another hormone involved in regulating blood sugar and appetite. But McGuire says GIP isnt well understood, and its not clear whether the addition of GIP is driving the increased weight loss or if tirzepatide is just better at activating GLP-1. We just dont have a way to unravel that biology right now, he says.

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The Race for the Next Ozempic - WIRED

One of the many immersive mechanics in Once Human is the ability to gain or lose weight organically. Buried beneath a complex web of mechanics, the nourishment system in this game feeds into a weight class mechanic the game does not tell you about. Naturally, much like in real life, you can tuck on a few pounds without knowing about this invisible meter.

Thankfully, losing weight in Once Human is much easier than in real life. In this guide, we will go over how.

The easiest way to lose weight in Once Human is to eat food that will give you the Gastric Discomfort debuff. Simply hunting some deer and eating the uncooked meat will induce this effect, for example. Other methods include directly drinking dirty water without boiling it or eating spoiled food.

As long as you have this debuff, you will gradually lose weight. However, the weight loss is a mere side-effect of the real penalty - which is decreased maximum HP. Thankfully, you can also cure Gastric Discomfort by crafting Antibiotics from the Supplies workbench.

If you're in a PvP server and want a less risk-averse way of losing weight in Once Human, you can resort to food that has the 'Weight Watchers' buff, including Fat-burning Juice.

Also Read: All active Once Human Redeem Codes

To gain weight in Once Human, all you have to do is eat food items tagged with Muscle-building. These are most food items cooked with Corn Oil, such as Fish and Chips. These are pretty advanced recipes that require some Memetic Point investments into cooking perks, though.

An alternative method is getting the Extradimensional Cat Deviant companion. Sleeping with this companion equipped will cause you to gain weight at quite a rapid rate.

Read More: All Deviant companions in Once Human

Why would you want to gain or lose weight? To make better use of the game's player weight mechanic. You are assigned a weight class during the character creation stage of Once Human depending on your 'Fitness' slider.

The gist of the mechanic is that each weight class incentivizes specific gameplay approaches with buffs and debuffs.

Generally, you want to stay in the moderate weight class to get the best buffs. This is why you will eventually have to resort to one of these methods to manipulate your way past the character creation menu.

This concludes our guide to gaining or losing weight in Once Human. Check out our other articles on this game here:

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How to gain or lose weight in Once Human - Sportskeeda

Keith Lee's "WWE NXT" success story seemed to position the star for a major main roster run, and many fans were filled with excitement for what he could accomplish on "Raw" or "SmackDown." Unfortunately, Lee's main roster run remains one of the worst call-ups in recent history, and it was largely due to his physique.

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Speaking on"Talk is Jericho," Lee looked back at his run with WWE, and noted how the promotion forced him to undergo many changes, such as not performing many of the athletic moves he's known for. "I am 100% certain it was some sort of an attempt at a test or such," he said.

Additionally, even when he rebranded himself as "Bearcat" Keith Lee, the company continued to strip away his move set. "Where the double chop I've been known for, they snatched that. They didn't want me looking at the crowd at all."

However, things didn't end there for the former WWE Superstar. According to a report from"Wrestling Observer Newsletter," after Lee contracted COVID-19, his physical ability worsened and he looked visibly bigger compared to when he first got sick. Sadly, this ended up being one of the believed reasons for Lee's WWE release.Furthermore, Lee's health issues are still a cause for concern today, and he's currently not been featured for months on AEW programming due to his continued struggles.

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Wrestlers Told To Lose Weight Or They Would Be Fired - Wrestling Inc.

Summary

Amy Slaton from 1000-lb Sisters recently shared a fun dance video on TikTok celebrating her life after losing weight. The 36-year-old mother of two was once over 406 pounds, feeling unhappy and stuck in a stagnant lifestyle. Amy struggled to lose weight and change her eating habits, especially because of her close relationship with her best friend and sister, Tammy Slaton, who faced similar challenges. Finally, Amy decided it was time to prioritize her health and opted for weight loss surgery, leading her to shed over 125 pounds.

Amy has become much happier since having two babies and her divorce from her husband, Michael Halterman.

She is living her best life in 2024 and enjoys sharing it on social media. Amy's friend, Ollisha Davis, recently posted a TikTok video titled "the time is now! You work hard, but you gotta live hard." The clip showed the 1000-lb Sisters star dancing with her friend and appearing slimmer than before.

Amy looked cheerful in the video and posed for the camera. She flaunted her defined jawline and walked to a car, indicating she was now fit enough to move quickly.

Reality TV is more popular than ever. With so many to choose from, here are some of the best reality TV shows to stream or watch right now.

Amy has made significant progress since losing 124 pounds over the past three years. The Dixon, Illinois native is now physically fit and mentally stronger. She leads an active lifestyle, balancing parenting her two kids and spending time with friends. Tammy's recent weight loss has also had a positive impact on Amy. Both sisters have become more fit and no longer encourage each other to engage in unhealthy habits. Instead, they inspire each other to continue their fitness journey and stay active. Amy's recent dance video shows her growth, which is why 1000-lb Sisters fans continue to support her.

Amy deserves all the likes and positive comments she receives. She has truly accomplished what many thought was impossible. Amy has lost weight and achieved numerous milestones, including becoming a mother and completely changing her lifestyle.

In 2024, Amy lives a healthy life that inspires her over 648k followers. She prioritizes her health and puts all her effort into caring for her children. Unfortunately, the reality star recently experienced significant marital problems with her estranged husband, Michael. Hopefully, 1000-lb Sisters season 6 will reveal what the future holds for Amy.

Amy isn't the only cast member of 1000-lb Sisters who has turned her life around. Tammy has also followed in her younger sister's footsteps and completely transformed her life in the last two years. She has successfully lost 440 pounds and now loves sporting fashionable outfits. Amy's other siblings have also achieved similar weight loss milestones. Amy's brother, Chris Combs, has lost over 150 pounds. Her half-sister, Amanda Halterman, has also shed significant weight, as seen in her latest pictures. Hopefully, Amy's journey toward weight loss will keep motivating 1000-lb Sisters cast members to keep reaching their fitness goals.

Tammy Slaton

37 years old

Lost 440 pounds

Diet, exercise, weight loss surgery

Amy Slaton

36 years old

Lost 125 pounds

Diet, exercise, weight loss surgery

Chris Combs

41 years old

Lost 150 pounds

Diet, exercise, weight loss surgery

Amanda Halterman

43 years old

Lost 300+ pounds

Had weight loss surgery (twice)

Misty Wentworth

48 years old

Unknown

Had weight loss surgery

1000-Lb Sisters is available to stream on MAX and Discovery Plus.

Source: Ollisha Davis/TikTok

1000-lb Sisters follows sisters Amy Salton-Halterman and Tammy Slaton in their home in Dixon, Kentucky, covering their daily lives, weight loss attempts, and subsequent weight loss surgery. The show covers such moments as attempts to have children, medical visits, and dramatic emergency room visitations. The family wrestles with supporting their daughters and their weight loss efforts while struggling with their own life troubles.

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1000-Lb Sisters Star Amy Slaton Is Living Her Best Life After Weight Loss Transformation - Screen Rant

Jon Gosselin and his daughter Hannah Gosselin shed a combined total of 75 pounds by using a base semaglutide the primary ingredient in popular weight-loss drugs like Ozempic and Mounjaro.

The former Jon & Kate Plus 8 stars didnt name the medication they used, but Hannah revealed she lost 25 pounds, and Jon shed more than 50 pounds.

I feel great. Im really happy, Hannah, 20, told Entertainment Tonight in an interview published Tuesday.

The father-daughter duo worked with Dan Holtzs Beverly Hills Rejuvenation Center where they each got a prescription for the popular weight-loss drug.

When I put on my pair of shorts that I wore two years ago I danced around my room. I was so happy. It was the best feeling ever. You probably would not have caught me in a swimsuit last summer. I dont even think I went to the beach, Hannah raved.

She added, I have been spending my whole summer at the pool, at the beach, out with my friends. It really is a confidence booster to know that you look in the mirror and youre happy with the way that you look.

In addition to the injections, Jon, 47, also underwent CellSound treatments a non-invasive treatment to stimulate cells and give skin a more youthful appearance and testosterone adjustments.

I think confidence level. I work out at the beach and sometimes I dont wear a shirt because its 100 degrees outside now. Before I would just sweat through it, now [I take it off].I have these things called abs. They just appeared, Jon gushed.

Both Jon and Hannah are now working on weaning ourselves off of the semaglutide and continuing to live an active lifestyle that centers around working out and eating high-protein meals.

Itll be a short-term plan thatll help us get to where we want to be. Once we get to our goal then its really going to be teaching Jon the lifestyle and how to maintain healthier lifestyle choices, Holtz previously told ET.

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Jon spoke to Page Six in April and revealed that he had lost 32 pounds in two months.

You know whats annoying? The regret of not starting it 10 years ago. I feel amazing! Like, why didnt I do this sooner? Maybe it wasnt the right time, he told us at the time.

The former TLC star added that the medication also helped me stop drinking and get his appetite under control.

I was able to really refocus my diet that way. I just focused on consuming what I need to consume in a healthy manner, he shared.

Jon previously admitted that he gained 35 pounds after he began DJing full time from around 10 p.m. to 2 a.m. several nights a week and quit his IT job.

Jon rose to fame with the hit show Jon & Kate Plus 8 with his ex-wife, Kate Gosselin, and their eight kids, including Hannah. However, the two separated in 2009 and had a tumultuous divorce that resulted in him being estranged from six of their children.

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Jon Gosselins daughter Hannah reveals how much weight she lost with semaglutide - Page Six

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