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A groundbreaking new study on transgender athletes has found trans women retain a 12% advantage in running tests even after taking hormones for two years to suppress their testosterone. The results, researchers suggest, indicate the current International Olympic Committee guidelines may give trans women an unfair competitive advantage over biological women.

World Rugby recently became the first sports federation to ban trans women from womens rugby, citing significant safety risks and fairness concerns. But most sports still follow IOC guidelines from 2015, which permit trans women to play against biological women providing their testosterone remains below 10 nanomoles per litre a figure higher than average biological female levels, which range from 0.12 to 1.79nmol/L.

However the new study, based on the fitness test results and medical records of 29 trans men and 46 trans women who started gender affirming hormones while in the United States Air Force, appears to challenge the IOCs scientific position.

The research, published in the British Journal of Sports Medicine, found that before starting their hormone treatment trans women performed 31% more push-ups and 15% more sit-ups in one minute on average than a biological women younger than 30 in the air force and ran 1.5 miles 21% faster.

Yet after suppressing their testosterone for two years a year longer than IOC guidelines they were still 12% faster on average than biological females.

The trans women also retained a 10% advantage in push-ups and a 6% advantage in sit-ups for the first two years after taking hormones, before their advantage disappeared. But the researchers say they may underestimate the advantage in strength that trans women have over cis women because trans women will have a higher power output than cis women when performing an equivalent number of push-ups.

The scientists conclude by saying more than 12 months of testosterone suppression may be needed to ensure that transgender women do not have an unfair competitive advantage when participating in elite level athletic competition.

When it initially published its transgender guidelines five years ago, the IOC said its overriding sporting objective is and remains the guarantee of fair competition. However, its plans to lower the testosterone limit to 5nmol/L came to nothing because the issue was so contentious. Instead the IOC indicated it wanted sports to implement their own transgender policies.

When asked for its response to the new research the IOC said it was now working on a a framework for voluntary guidelines on the basis of gender identity and sex characteristics, adding: Overall, the discussions to date have confirmed considerable tension between the notions of fairness and inclusion, and the desire and need to protect the womens category, all of which will need to be reconciled. The IOC aims to release this framework in 2021.

The academic research also highlighted the benefits of testosterone for trans men. Before taking the hormone, they performed 43% fewer push-ups and ran 1.5 miles 15% slower than their male peers. But after one year there was no longer any difference in push-ups or run time, and the number of sit-ups performed by trans men exceeded the average performance of their male peers.

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Trans women retain 12% edge in tests two years after transitioning, study finds - The Guardian

Men have a greater performance advantage over women in cricket, golf and tennis compared to sports such as running or swimming according to new research, which also finds that testosterone blockers taken by transgender women only minimally reduce the biological advantage underpinning performance.

The study, published in Sports Medicine, found that while elite men are around 10-13% faster than elite women at running and swimming, the gap is between 29% and 52% when it comes to bowling cricket balls, hitting long drives, weightlifting and in sports that generally rely more on muscle mass and explosive strength.

Performance differences larger than 20% are generally present when considering sports and activities that involve extensive upper body contributions, the study adds. The gap between fastest recorded tennis serve is 20%, while the gaps between fastest recorded baseball pitches and field hockey drag flicks exceed 50%.

However when transgender women suppress testosterone for 12 months, researchers found that the loss of lean body mass, muscle area and strength was only around 5%. Therefore, they say, the muscular advantage enjoyed by transgender women is only minimally reduced when testosterone is suppressed and small compared to the baseline differences.

The results are significant because under the current International Olympic Committee guidelines, transgender women are allowed to compete in female sports categories if they suppress their testosterone below 10 nmol/L for 12 months before and during competition.

Yet even when testosterone was suppressed to around 1 nmol/L it did not remove the anthropometric and muscle mass/strength advantage in any significant way although the authors say the reduced cardiovascular performance may generate smaller retained advantage in endurance sports.

The study raises significant questions for sport, with the paper stating the IOC may need to reassess whether its current guidelines for transgender women are fair or safe for female competition. They also ask whether, from a medical-ethical standpoint, it is acceptable for the IOC to ask trans women to significantly reduce their testosterone if it does not deliver on its stated aims.

Meanwhile researchers also found the biological gap between women and men is so great that 10,000 males have personal-best times that are faster than the current Olympic 100m female champion, as does the 14-year-old male schoolboy 100m record holder.

These data overwhelmingly confirm that testosterone-driven puberty, as the driving force of development of male secondary sex characteristics, underpins sporting advantages that are so large no female could reasonably hope to succeed without sex segregation in most sporting competitions.

Read more:
Strength of trans women drops slightly after year of treatment, research claims - The Guardian

Men are three times more likely to need intensive care treatment from a coronavirus infection than women and also have a greater risk of death, according to a new global study.

Analysis of more than 3 million cases around the world published in the journal Nature Communications on Wednesday showed that there was no difference in the proportion of either sex actually getting infected.

But once COVID-19 positive, male patients have almost three times the odds of requiring intensive treatment unit admission and higher odds of death compared to females, the study said. The death rate was estimated to be 1.4 times more likely for men.

The researchers from the University College London and the University of Cape Town used data from 46 different countries and 44 US states to confirm what had until now only been anecdotal signs of differences.

With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon, the study said.

The confirmation of this sex disparity with global data has important implications for the continuing public health response to this pandemic, it stressed.

The study noted a few gender-based socio-cultural and behavioral differences that could contribute to the sex difference with men more likely to smoke, go out into crowds and fail to wash their hands with soap.

A more likely cause, however, is the fundamental differences in the immune response between males and females, the study said, noting that the male sex hormone testosterone suppresses the immune system.

Interestingly, testosterone-deprivation therapy for prostate cancer has been associated with improved outcomes for COVID-19, suggesting that suppression of the immune response by testosterone, as well as the protective effect of oestrogen, may underlie the observed sex-bias, the study suggested.

These data have implications for the clinical management of COVID-19 and highlight the importance of considering sex as a variable in fundamental and clinical research, the paper said.

The rest is here:
Men are 3 times more likely to need ICU treatment from COVID-19: study - New York Post

Shabana Guptaguptasha@grinnell.edu

As the pandemic continues, so do its accompanying struggles; something especially true for the nonbinary and trans community. Economic instability, job discrimination and dysphoria are all hitting harder than normal for the Transgender and Gender Non-Binary (TGNB) students stuck at home with minimal contact with friends and other TGNB folk. A Columbia University study found that a high percentage of TGNB people were struggling during COVID-19, which begs the question: how are Grinnells TGNB students doing?

Grinnell has a lot of TGNB students who are living openly with their identities. Some students have relatively accepting families, even if their families are not perfect. In some cases, this lack of acceptance affected their decisions on where to live during lockdown.

Romeo Garcia 23 is currently living on campus. There are a couple reasons why he chose to be in Grinnell instead of at home in Oklahoma. One of them is because of his gender expression and the constraints he feels when living with his parents.

Gender presentation is a big portion of the issues many TGNB students must face in their home environments. For students living by themselves or with friends, quarantine is a wonderful time to explore clothing and new interests. For those living at home, options may be more limited. Expectations from family may cause them to present in a way that isnt always in line with the students needs.

Garcia said that his parents accept his gender identity, and that they took the transitioning relatively well. He said that their main problem is with his gender expression. They dont understand that a boys favorite color could be pink, or that a boy could like glitter or nail polish or eyeliner, god forbid, Garcia said.

They dont understand that a boys favorite color could be pink, or that a boy could like glitter or nail polish or eyeliner, god forbid Romeo Garcia 23

His parents, especially his stepdad, expect that Garcia fits traditionally masculine stereotypes. You cannot complain, you cannot feel things. Thats my moms idea of masculinity, Garcia said. The second a trans person does stuff thats not expected of their gender, theyre [his parents are] like, So that changes you back now.

Garcia said these expectations became extremely stressful when he was home for the summer. Youre expected to perform for them. Like, this is causing me distress and unhappiness.

Garcia also made sure to present only as masculine when outside of his parents house. I dont want to be perceived as genderqueer or anything. Id get beat up or something.

There has been a rise in hate crimes against the TGNB community during 2020. The Human Rights Campaign reported 40 known murders of TGNB people during 2020, making it the most violent year since the HRC started recording TGNB violence in 2013.

Being in Grinnell for the school year is a lot more comfortable for Garcia, and he said that he can wear and act in whatever way pleases him without fear of repercussions. Its such a queer space that I can queer my expression more. Like yes, this is my ideal actually, this is what brings joy for me.

Katie Hidlebaugh 22 is living at home with their dad, stepmom and brothers. Many of Hidlebaughs issues with living at home are a result of their gender presentation. Their dad made comments about what they were wearing before they were comfortable talking about identities and gender presentation with him. Nothing major, its just a lot of microaggressions, they said. Their dad has since stopped referring to them in gendered terms. Hidlebaugh said that their mom has been really good at helping with dysphoria. Their moms house was destroyed in the derecho, though, so Hidlebaugh is not able to live with her for now.

Hudson Clulow 23 has also been living on campus this semester. They stayed over the summer for a variety of reasons, one of which was their hometowns constrictive culture.

Clulow came out as trans in 9th grade, about a year after coming out as gay. Their family is supportive now, though it started out rocky. The small community they live in still tends to identify them with their dead name, the name they were assigned at birth, despite knowing their current name. When everyone knows you personally theres just a sense of I can ask you whatever I like, Clulow said.

When they went to the grocery store or picked up their younger sister, people would come up to them and say, Oh, I know youre going by Hudson now, but Ive always known you as [deadname]. According to Clulow, the conversation would often be followed by some hugging.

Facing the broader home community has also presented some issues for Hidlebaugh, who has run into difficulties at their workplace. They have their pronouns on their nametag, which means people tend to look at them strangely after noticing. They said that most of the time people are accepting, though there was an instance involving their manager. According to Hidlebaugh, his manager thought it was a political statement.

Hes a baby boomer they said.

COVID-19 has also gotten in the way of necessary procedures and activities for trans youth. Jax Seiler 22 has a relatively accepting home life and is currently living with his dad and brother. Other than confusion surrounding pronouns, his home life has been fine. His mom takes initiative when it comes to learning about trans topics. Seiler isnt living with his mom, but she does send him trans memes every so often.

The main issue that Seiler has faced because of COVID-19 is that his appointment for testosterone was canceled. It was scheduled before everything went on lockdown, but his nurse was out sick. The next week no one was able to get an appointment. Seiler said that he can generally pass as a dude.

The worst I have to deal with is getting misgendered until I get on T [testosterone], he said.

Grinnell TGNB students seem to be working around the conditions of COVID-19. The four students I spoke with for this article said that they have relatively supportive families, and their workplaces have an overall positive environment. There are probably students that have not been voiced in this story, and their experiences might be closer to what Columbia University found in their survey.

There is a diversity within the TGNB students experience of COVID-19. Like Garcia found, quarantine can be a good time to explore and experiment with gender expression. I can do funky gender things like wearing a skirt or a dress, he said. No ones here perceiving me, its not going to change the way a lot of people think about me.

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Checking in with Grinnell's TGNB community The Scarlet and Black - Scarlet and Black

About 40% of men aged 45 years and older have low testosterone levels, and symptoms include a low mood, energy, and sex drive, erectile dysfunction, and infertility.

While it's important to check in with a doctor to determine if you need testosterone replacement therapy, there are also many proven ways to boost testosterone levels naturally.

Increasing testosterone can improve your mood and energy, boost your libido, and help with muscle mass and bone density, says Kevin Codorniz, MD, chief of endocrinology for Loma Linda University Health.

Here are 6 ways that you can naturally increase testosterone production.

Exercising is beneficial for naturally boosting testosterone levels, says Mary Samplaski, MD, urologist with Keck Medicine of USC. She says that the most recent research surrounding exercise and testosterone is based on one hour of cardio, or aerobic exercise, such as running or brisk walking, three times a week.

A small 2016 study showed that in overweight men, increased physical activity by way of aerobic exercise training was effective in raising testosterone levels. It also showed that increased physical activity was more effective than dietary changes at increasing testosterone. Additionally, a 2012 study showed that men who were physically active had higher levels of testosterone than men who were sedentary.

There has also been research tied to testosterone and resistance or strength training. Codorniz says there may be an acute, or short-term, increase in testosterone concentrations immediately after resistance exercise, like weight lifting or using resistance bands. However, moderation is key. Codorniz warns that excessive exercise may actually lower testosterone levels.

When vitamin D levels are low, testosterone levels are often low, too, says Samplaski. In these cases, when you supplement with vitamin D, testosterone levels will likely rise.

Samplaski says vitamin D may act as a building block for testosterone, although the relationship between vitamin D and testosterone is not totally understood by researchers.

A 2011 study involved giving 200 men either a placebo or 83 g (3,332 IU) of vitamin D daily for a year. At the beginning of the study, vitamin D levels were in the deficiency range, and testosterone levels were relatively low. After the year of vitamin D supplementation, there was a significant increase in testosterone levels, compared to no significant increase in the placebo group.

Samplaski says some people try to cut fat out completely from their diet in order to become healthier, however, this can backfire if you're looking to raise testosterone levels, since fat is a precursor to testosterone.

In a small 2013 study, participants were given either virgin argan oil or virgin olive oil. After three weeks of consuming these healthy fats, testosterone levels increased significantly in both groups. There was a 19.9% increase in those who consumed virgin argan oil and a 17.4% increase in those who consumed the virgin olive oil.

Overall, Samplaski says it's important to consume healthy fats in moderation. To add more healthy fats to your diet, eat foods like:

Codorniz and Samplaski both say that drinking alcohol excessively can decrease testosterone. In fact, a 2019 review on substance abuse and testosterone highlighted previous research in which testosterone levels dropped 30 minutes after consuming alcohol.

People who are very heavy drinkers are most at risk for low testosterone, Samplaski says, since other hormones such as luteinizing hormone (LH) that signal the release of testosterone are affected and thrown off with heavy drinking. If you are looking to increase your testosterone levels, Samplaski suggests limiting yourself to three drinks per week.

Codorniz says that a lack of sleep, especially sleep deprivation, or getting less than five hours of sleep, can decrease testosterone concentrations. A small 2015 study showed that men who slept for five hours had 10% to 15% lower testosterone levels compared to when they slept for eight or more hours.

It's not just the amount of sleep that's important, it's also the consistency of the sleep schedule. Samplaski says erratic sleep schedules, such as those of shift workers, can throw off testosterone production. However, the relationship between sleep and testosterone is not totally understood, and research is ongoing.

Chronic psychological stress leads to higher levels of the hormone cortisol, commonly referred to as the stress hormone, Codorniz says. Cortisol and testosterone have an inverse relationship. As cortisol goes up, testosterone goes down.

Therefore, it's crucial to minimize stress if you want to raise your testosterone levels. A large 2005 study stated that high cortisol levels and low testosterone levels are key indicators of chronic stress, which can also increase your risk for long-term conditions like heart disease .

If you think you might have low testosterone, you should visit your doctor for an evaluation. Low testosterone symptoms may overlap with symptoms for other conditions that are easily treatable, so it's best to get a professional medical diagnosis first, Samplaski says.

Regardless, all of the above-mentioned lifestyle changes exercising, getting vitamin D, eating healthy fats, drinking less alcohol, getting enough sleep, and reducing stress will help increase your testosterone levels and boost your overall health. If these natural methods do not increase testosterone levels, you may need to discuss options such as testosterone replacement therapy with your doctor.

Read more from the original source:
6 natural ways to increase testosterone for more energy and a higher sex drive - Insider - INSIDER

Dear Dr. G,

I am a man in my mid-forties and while balancing my career and family time is always difficult, I manage it and I am mostly content with my life - except for two issues.

Firstly, my sexual appetite has been diminishing since my late 30s. My wife says that it is normal as we are raising two teenagers and as such have no time and energy for ourselves. Also, my wife and I have sex once every few months, and my friends tell me it is abnormal.

Secondly something that is not making me feel so sexy about myself is my

balding head, and I have read that male pattern baldness is characteristic of a

virile man with high levels of testosterone. Isnt that why Bruce Willis is perceived to be more masculine with a thinning scalp?

Therefore, I would Dr. G on the spot by asking if there is a link between hairlessness and virility. Is my declining sex life a symptom if an illness, and is this a reflection of a poor level of testosterone?

Also, would the use of hair loss products enhance or reduce my sexual appetite?

Regards

Hairless Harry

A close correlation between testosterone and male pattern baldness has been postulated for centuries. In fact, such a link had already been documented in the era of Hippocrates and Aristotle.

In the modern era, the first scientific evidence of the influence of testosterone on hair is studied by Hamilton from Yale in the 1960s in a study of 21 boys castrated for behavioural and mental problems.

The study - which continued until the boys were 18 - found that the castrated subjects had no endogenous testosterone and also had no signs of developing male pattern baldness in adulthood while the men with normal testicular functions tend to be more likely to have receding hair loss.

With that said, the association of hair loss with male hormone harbours a great deal more complexity than previously speculated.

The mere level of the male hormones does not determine hair loss, but testosterone is converted into a more active substance, dihydrotestosterone (DHT) that is more important in sexual desire and hair growth.

The active component of this metabolite is also believed to shrink the hair follicles in the scalp, stopping further growth and resulting in male pattern baldness.

Additionally, a man's degree of baldness is clearly not just determined by testosterone as it is also controlled by the genetic make-up of the man and their susceptibility to enzyme conversion.

Similarly, the libido of a man is not simply controlled by testosterone.

Other factors play important roles may include cultural upbringing, attitude towards sex and overall state of health.

As for hair loss products, the use of medications like Finasteride is well recognized in reversing male pattern baldness.

The mechanism of action for such drugs is to inhibit the conversion of testosterone to DHT, and as such it is not just useful in stopping the shrinkage of shrinking of hair follicles in the scalp; it is also widely used to prevent the progression of prostate enlargement.

Although the medication is useful in the treatment of prostatic aging process and hair loss, the side effects of diminished libido and erectile dysfunction is also well documented.

The American actor and producer Bruce Willis is widely regarded as an action hero after his portrayal of John McClane in the Die Hard franchise.

Of course, Willis is also well recognized, having a receding hairline from his

Moonlighting days to complete baldness as his career progressed.

Willis once admitted that "hair loss is Gods way of telling me I am human. In reality, male pattern baldness is a general progression of male aging. It is a biological process that is influenced by multifactorial parameters, rather than a surrogate market of male virility.

Similarly, sexual desire and libido is also a variable between men, influenced by the state of mind and state of health.

Many men facing dwindling sex life, with or without hair, often put Dr. G on the spot for answers to revive their action hero bedroom days.

His response is that hair loss and libido loss is Gods way of telling you are human, therefore do whatever is humanly necessary to be healthy and relive the action days!

Read more:
Hairlessness and Virility - The Star Online

TheGlobal Testosterone Replacement Therapy Market report by Reports and Data is an all-encompassing study of the global Testosterone Replacement Therapy market. The report serves as a prototype of the highly functional Testosterone Replacement Therapy industry. Our market researchers panel has performed quantitative and qualitative assessments of the global Testosterone Replacement Therapy market dynamics in a bid to forecast the global market growth over the forecast period. Reports and Data have taken into consideration several factors, such as market penetration, pricing structure, product portfolios, end-user industries, and the key market growth drivers and constraints, to endow the readers with a sound understanding of the market. The report provides the reader with a panoramic view of the Testosterone Replacement Therapy market, supported by key statistical data and industry-verified facts. Hence, it examines the size, share, and volume of the Testosterone Replacement Therapy industry in the historical period to forecast the same valuations for the forecast period.

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Market segments by Top Manufacturers:

Market split by Type, can be divided into:

Market split by Application, can be divided into:

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The latest report is furnished with a detailed examination of the Testosterone Replacement Therapy market and the global economic landscape ravaged by the ongoing COVID-19 pandemic. The pandemic has significantly affected millions of peoples lives. Besides, it has turned the global economy upside down, which has adversely impacted the Testosterone Replacement Therapy business sphere. Thus, the report encompasses the severe effects of the coronavirus pandemic on the Testosterone Replacement Therapy market and its key segments.

Geographical Scenario:

The global Testosterone Replacement Therapy market report comprehensively studies the present growth prospects and challenges for the key regions of the Testosterone Replacement Therapy market. The report continues to evaluate the revenue shares of these regions over the forecast timeline. It further scrutinizes the year-on-year growth rate of these regions over the projected years. The leading regions encompassed in this report:

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Key Coverage of the Report:

The report considers the following timeline for market estimation:

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Thank you for reading our report. In case of further queries regarding the report or inquiry about its customization, please connect with us. We will ensure your report is well-suited to your requirements.

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Latest Research on Testosterone Replacement Therapy Market | Competitors Analysis Report 2020 - The Haitian-Caribbean News Network

Future Prospects of the Global Testosterone Booster market The presented market study provides valuable insights to stakeholders, market leaders, upcoming market players, investors, and more who are aiming to solidify their presence in the global Testosterone Booster market. The report scrutinizes the various market trends that are expected to influence the growth of the Testosterone Booster market over the forecast 2020 to 2025.

The Testosterone Booster market report offers a holistic assessment of this industry vertical with focus on the key growth drivers, restraints, and opportunities molding the market dynamics over the forecast period.

According to the report, the market is projected to expand substantially, recording a CAGR of XX% over 2020-2025.

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The disruptions caused by the coronavirus pandemic has brought lot of uncertainties in the market. In addition to the near-term revenue drift, some industries are expected to face difficulties even once the economy recovers from this global crisis.

Practically, all the organizations in various sectors have revised their budget allocations to ensure profitability in the upcoming years. Our thorough investigation of this business space can strengthen your action plan and assist you in building strong contingency plans.

The research document also boasts of a comprehensive analysis of the various industry segmentations in order to impart a deeper understanding of the markets revenue prospects.

Key inclusions of the Testosterone Booster market report:

Testosterone Booster Market segments included in the report:

Regional division: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.) and Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa)

Regional and country level bifurcation of the market.

Product spectrum: D Aspartic Acid, Vitamin D3 and Other

Application terrain: Teenagers and Adults

Important insights of each application segment including revenue and sales volume.

Competitive framework: Testofuel, Nugenix, Prime Male, GNC, Prime Male, TestoTEK, TestoRush, TestoGen, TEK Naturals and Monster T

Key questions answered in this report

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Testosterone Booster Market to witness an impressive growth during the forecast - News by aeresearch

The coronavirus disease 2019 (COVID-19) pandemic has caused a backlog in FDA drug approvals, and many experts fear that the pandemic will have a negative effect on drug development.1

However, a new report published by OptumRx challenges that assumption and argues that although delays have occurred, COVID-19s impact on drug development has been minimal. Several new and promising drugs are making their way through the FDA pipeline with expected approvals in the fourth quarter of 2020 and the first quarter of 2021, according to OptumRx.1

Five Drugs to Watch Out For in 2020 Q4 and 2021 Q1

1. Roxadustat (FibroGen, expected FDA decision: December 23, 2020)

Roxadustat is intended to treat anemia, which occurs when there is insufficient hemoglobin in the blood, associated with chronic kidney disease. Approximately 4.8 million people are affected by the condition in the United States. If the drug is approved, it will be the first novel treatment for chronic kidney disease related anemia since 1989. Additionally, roxadustat would offer an oral alternative to the currently available injectable product. A sale price has not yet been established.1

2.Relugolix (Myovant, expected FDA decision: December 20, 2020)

Relugolix is intended to treat male patients with advanced prostate cancer, the second most common cancer in American men. In 2020, there will be an estimated 192,000 new prostate cancer cases and 33,000 deaths. Relugolix works by blocking the hormone that stimulates testosterone production. Testosterone plays a key role in the growth of prostate cancer tumors and treatment often focuses on reducing levels of the hormone in the body. If approved, it will be the first oral GnRH receptor antagonist for advanced prostate cancer.1

3.Inclisiran (Novartis, expected FDA decision: December 2020)

Inclisiran is intended to treat elevated low-density lipoprotein cholesterol (LDL-C) in patients with atherosclerotic cardiovascular disease and familial hypercholesterolemia, which is caused by a genetic mutation that impacts the breakdown on LDL-C. More than 29 million people in the United States are living with these conditions, and 22 million are treated with oral lipid lowering therapies. Even though inclisiran is a PCSK9 inhibitor, it is also a small interfering RNA. Although inclisiran is a late entry to the market, it only has to be administered by subcutaneous injection once every 6 months. The 2 other drugs on the market, evolocumab and alirocumab, have to be administered every 2 to 4 weeks.1

4. Berotralstat (BioCryst Pharmaceuticals, expected FDA decision: December 3, 2020)

Berotralstat is meant to prevent hereditary angioedema (HAE) attacks, which are caused by a genetic defect that causes a biochemical imbalance that releases fluids outside of the blood vessels into surrounding tissues. Approximately 7500 people are treated for HAE in the United States. Berotralstat would be a late comer to a crowded market; however, if approved, it would be the first oral, non-biologic, once-daily treatment. This could provide the drug with an advantage over its competitors, according to OptumRx.1

5. Lisocabtagene maraleucel(Bristol Meyers Squibb, expected FDA decision: delayed)

Lisocabtagene maraleucel is intended to treat adult patients with diffuse large B-cell lymphoma that has either relapsed or does not respond to treatment after at least 2 prior therapies. An initial decision for the drug was slated for November 16, 2020. However, the FDA was not able to conduct an inspection of a third-party manufacturer facility in Texas due to COVID-19 travel restrictions. Action on the application is being deferred until an inspection can be completed.1

Emergency Use Authorizations to Watch out for in 2020 Q4 and 2021 Q1

1. mRNA-1273 COVID-19 vaccine (Moderna Inc)

Moderna announced that its COVID-19 vaccine candidate is 94.1% effective against COVID-19, with a 100% efficacy against severe cases. If approved, 20 million doses will be available in the United States by the end of 2020, with 500 million to 1 billion doses available globally in 2021.2

2. mRNA COVID-19 vaccine (Pfizer Inc)

Pfizer Inc. and BioNTech SEs COVID-19 vaccine, BNT162b2 is 95% effective against COVID-19. No serious safety concerns were observed to date. If approved, an expected 50 million doses will be available in 2020 and 1.3 billion doses available by the end of 2021.3REFERENCE:

Originally posted here:
Five Potential FDA Approvals to Watch in the Coming Months - Pharmacy Times

The age old debate from women is that men just whine and moan when they're sick. Well, it is now proven science that men have the right to lay in bed because they truly are feeling worse than women think.

Researchers at Johns Hopkins University collected nasal cells from men and women and infected the cells with "influenza A". The kicker is that those researchers injected estrogen into some of those same cells. It was found that the cells that were injected with estrogen reduced the replication of the virus.

In other words, estrogen helped fight off the infection and reduced the symptoms associated with the virus.

It was also noted that testosterone, the male hormone, actually weakens the immune system making it less likely to fight off the virus.

Meaning, men feel worse than women when they're sick.

In a study from Memorial University of Newfoundland, researcher Kyle Sue found that men have more hospital admissions due to the flu. The death rate from the flu is also higher in men. The research also backed up that a man's immune system is weaker simply because of testosterone.

So ladies, if your man is sick, and you think he's complaining and moaning for no reason, he's not. He's not faking it, he's not trying to get out of his honey do list, he's not being lazy, he really does feel bad. Give him some time to rest and some chicken noodle soup.

Originally posted here:
Ladies, Science Officially Says Man Flu is a Real Thing - knue.com

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