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Men who suffer from severe cases of coronavirus could experience problems with fertility, a new study has warned.

Dr Dan Aderka, from the Sheba Medical Centre in Israel, conducted the study and believes that the virus also impaired sperm motility, due to damage to testicular cells.

Reduced sperm volume and motility

For the study, Dr Aderka screened healthy men for evidence of coronavirus and found that, in some cases, the virus had made its way into their sperm.

It was also found that there was a 50 per cent decrease in sperm volume, concentration and motility among patients with moderate coronavirus symptoms, even 30 days after their diagnosis.

Post-mortem tests of 12 Covid-19 patients also demonstrated moderate to severe changes in the testicular cells that support sperm development and those producing testosterone, the hormone that induces sperm division and multiplication.

Speaking to the Jerusalem Post, Dr Aderka said, As normal sperm maturation takes 70 to 75 days, it is possible that if we are doing a sperm examination two and a half months after recovery, we may see even more reduced fertility. It could be even more detrimental.

Destroying testicular cells

Coronavirus can destroy two types of cells in the testicles, sertoli and leydig, according to Dr Aderka. Sertoli is responsible for sperm maturation, while leydig produces testosterone. Coronavirus can bind to the ACE2 receptors on the surface of these cells and destroy them, as it can also do in the lungs.

He said, Interestingly, an enzyme called TMPRSS2 assists the virus in binding to the ACE receptor, facilitating its internalization into the cells.

This phenomenon may explain the higher Covid-19 morbidity and mortality of men compared to women.

He also added that this may also explain the lower morbidity and mortality of children, whose testosterone levels are low.

Dr Aderka said it is still unclear if this effect is reversible, or if it is possible for men to recover over time. The Sheba Medical Center plans to examine the same patients it screened in six months and a years time to examine any changes.

Read more from the original source:
Coronavirus could cause infertility in men - according to a new study - Derry Journal

At first, the reality star, who shares three kids with Kourtney Kardashian, originally thought he had contracted Covid-19, saying, "Lately, I've just had no energy to do anything. I wake up and I'm just shot."

He went on, explaining, "I don't have the drive to get up and run around with my girlfriend and my kids. I just don't have the energy. I don't know if I'm getting old or I'm just not in great shape, but I just want to see if there's anything wrong with me."

"I'm definitely a drop nervous to do all these blood panels, because I've put this vessel through a lot of trauma, I'm not going to lie," he said. "I'm definitely scared, but if there's anything wrong with me, whatever is the best way to get my body functioning better is what I'm going to do."

He added that his body has taken a beating.

"I feel like there's definitely been some stress in my life," he continued. "Missing my parents, it's really hard. My life hasn't always been easy. I used to drink and party and go out a ton, so my body, it's been through some rough waters and taken some pretty bad beatings. I never thought that there was a possibility any of that stuff could affect me in the long run."

Disick has openly checked himself into rehab before.

When his blood results came back, Disick was told that his testosterone levels were "clinically low."

"I'm very thankful that there was nothing serious," he said. "It could be from a number of reasons, so my doctor suggested I meet with a nutritionist, who did a more detailed blood test to find out why my testosterone is so low and to see exactly what's working and what's not working on my body."

He has since changed his diet and is now taking supplements.

Read the original:
Scott Disick learns he has low testosterone, admits his body has been through 'some rough waters' - CNN

Covid-19 could lower testosterone levels and libido in men - heres what the new study found(Photo: Shutterstock)

A new study has revealed that men who contracted Covid-19 have their testosterone levels lowered by 30 per cent, on average.

Even two thirds of men who showed no symptoms reported a loss of libido.

Researchers in Turkey analysed levels of sex hormone in 232 men who were hospitalised after they tested positive for Covid-19.

What is hypogonadism?

More than half (51 per cent) of the men had developed a condition called hypogonadism, meaning their bodies did not produce enough testosterone.

On average participants levels were drained by 30 per cent post-infection, to borderline unhealthy levels.

Academics from the University of Mersin who ran the study claim there is a direct correlation between severe illness and lower testosterone levels.

Lead author, Professor Selahittin ayan (a urologist at the university) said, In our study, the mean total testosterone decreased, as the severity of the Covid-19 increased.

The mean total testosterone level was significantly lower in the ICU group than in the asymptomatic group.

In addition, the mean total testosterone level was significantly lower in the ICU group than in the standard care group.

Why do men need testosterone?

Testosterone is key to the development of sex organs and muscle growth. The hormone also helps regulate the bodys immune responses, including fighting off viral infections.

Low levels have been linked to an increased risk of dying from the flu, as well as inflammation, heart disease and high blood pressure.

A healthy level of testosterone is usually considered to be above 300 nanograms per decilitre (ng/dl).

Results in the study showed that patients saw their levels drop by a third, on average, from 458 ng/dl to 315 ng/dl.

Professor ayan describes the uses of the hormone saying, Testosterone is associated with the immune system of respiratory organs, and low levels of testosterone might increase the risk of respiratory infections.

Low testosterone is also associated with infection-related hospitalisation and all-cause mortality in male in ICU patients, so testosterone treatment may also have benefits beyond improving outcomes for Covid-19.

See the original post here:
Covid-19 could lower testosterone levels and libido in men - heres what the new study found - Shields Gazette

The testosterone replacement therapy market is segmented on the lines of its product type and ingredient type. Based on product type the testosterone replacement therapy market is segmented into oral, implants, gums/ buccal adhesives, injections, patches and creams/ gels. The testosterone replacement therapy market is segmented on the lines of its ingredient type like testosterone, testosterone cypionate, testosterone enanthate, testosterone undecanoate and methyl testosterone. The testosterone replacement therapy marketis geographic segmentation covers various regions such as North America, Europe, Asia Pacific, Latin America, Middle East and Africa. Each geography market is further segmented to provide market revenue for select countries such as the U.S., Canada, U.K. Germany, China, Japan, India, Brazil, and GCC countries.

Browse Full Report: https://www.marketresearchengine.com/upcommingreport/testosterone-replacement-therapy-market

Testosterone is responsible for the improvement of male sexual characteristics and this hormone formed by the testicles. It is also important to maintain various functions such as sexual function, bone growth, adequate levels of red blood cells, and a sense of well being and muscle bulk. Insufficient production of testosterone causes erectile dysfunction. Erectile dysfunction occurs due to decreased testosterone production to overcome this testosterone replacement therapy is used to improve the problem. Testosterone replacement therapy occurs in various forms containing its own set of advantages and hazards such as subdemal pellets, transdemal patches and injections. Testosterone replacement therapy also helps to recover symptoms of low testosterone. Low testosterone is caused due to age growth it generally lowers down after the mid 30s and further decreases accordingly to the age factor.

The scope of the report includes a detailed study of global and regional markets of Testosterone Replacement Therapy Market. The reasons given for variations in the growth of the industry in certain regions.

Global Testosterone Replacement Therapy Market is expected to exceed more than US$ 1.0 billion by 2024 at CAGR of 4% in the given forecast period.

The major driving factors of testosterone replacement therapy market are as follows:

Rise in incidence of testosterone deficiency.Increase in geriatric populace with high risk of testosterone deficiency.Increasing awareness about testosterone substitute therapy.

The restraining factors of testosterone replacement therapy market are as follows:

High possibility of side effects associated to testosterone replacement therapy.Patent expiry of key drugs and entry of generics.

The report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global market. Key players profiled in the report include AbbVie, Inc., Allergan plc, Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Mylan N.V., Novartis AG, and Pfizer, Inc. Company profile includes assign such as company summary, financial summary, business strategy and planning, SWOT analysis and current developments.

The Testosterone Replacement Therapy Market has been segmented as below:

The Testosterone Replacement Therapy Market is Segmented on the lines of Product Type Analysis, Ingredient Type Analysis and Regional Analysis. By Product Type Analysis this market is segmented on the basis of Oral, Implants, Gums/Buccal Adhesives, Injections, Patches and Creams/Gels.

By Ingredient Type Analysis this market is segmented on the basis of Testosterone, Testosterone Cypionate, Testosterone Enanthate, Testosterone Undecanoate and Methyl Testosterone. By Regional Analysis this market is segmented on the basis of North America, Europe, Asia-Pacific, MEA and Rest of the World.

This report provides:

1) An overview of the global market for testosterone replacement therapy and related technologies.

2) Analyses of global market trends, with data from 2015, estimates for 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2024.

3) Identifications of new market opportunities and targeted promotional plans for testosterone replacement therapy.

4) Discussion of research and development, and the demand for new products and new applications.

5) Comprehensive company profiles of major players in the industry.

Request Sample Report from here: https://www.marketresearchengine.com/upcommingreport/testosterone-replacement-therapy-market

Table of Contents

1 INTRODUCTION

2 Executive Summary

3 Global Testosterone Replacement Therapy Market Industry Analysis

4 North America Testosterone Replacement Therapy Market Analysis

5 Europe Testosterone Replacement Therapy Market Analysis

6 Asia Pacific Testosterone Replacement Therapy Market Analysis

7 Middle East and Africa (MEA) Testosterone Replacement Therapy Market Analysis

8 Latin America Testosterone Replacement Therapy Market Analysis

9 Global Testosterone Replacement Therapy Market, Country Snippets

9.1. Global Testosterone Replacement Therapy Market Revenue, by Country, (US$ Mn), 201420249.2. U.S. Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.3. Japan Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.4. Germany Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.5. U.K. Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.6. Canada Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.7. China Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.8. Brazil Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.9. Mexico Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.10. United Arab Emirates (UAE) Testosterone Replacement Therapy Market Revenue, (US$ Mn), 20142024

10 Company Profiles

10.1. AbbVie, Inc.

10.2. Allergan plc

10.3. Bayer AG

10.4. Endo Pharmaceuticals, Inc.

10.5. Eli Lilly and Company

10.6. Kyowa Kirin International plc

10.7. Mylan N.V.

10.8. Novartis AG

10.9. Pfizer, Inc.

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Topical Drug Delivery Market Size, Industry Share, Approaches and Forecast By 2022

Tuberculosis Testing Market is Expected to Get US$ 2600 Million By 2022

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Testosterone Replacement Therapy Market Industry Development Trends & Competitive Analysis by Leading Industry Players - The Daily Chronicle

Recently published in Nature Magazines Scientific Reports, Dr. Lee Gettler, an associate professor of anthropology at Notre Dame, has completed a new study which links testosterone levels in fathers with their broader cultural settings.

Gettler said that he became interested in his research when he met Dr. Adam Boyette, who is now a senior researcher at the Max Planck Institute for Evolutionary Anthropology, at a conference put on by the Jacobs Foundation.

[The Jacobs Foundation] put together a conference that was specifically bringing together a really large group of scholars who specifically studied fathers from diverse perspectives psychology, sociology, neuroscience, anthropology to try to get all these people in the same room to talk about how we can begin to kind of best understand the way that fathers impact human children, Gettler said.

A father from the BaYaka tribe poses for a photo with his young sonin the northern Republic of Congo, where Boyette did his field work.

Boyette did his dissertation research in a remote region in northern Republic of the Congo accessible by a weeklong journey from the capital city of Brazzaville. There he studied the BaYaka and Bondongo people who live a very different lifestyle than one were used to. Although located in the same village, the two tribes have their own distinct cultures. The BaYaka people are a more egalitarian society, focused on cooperative living, whereas the Bondongo people are fisher-farmers whose society is hierarchical and status-based.

Boyette noted that the differences between these two communities who live in such close conjunction is really what drew their study to this remote corner of the world.

Our interest was to work with both groups and try to understand differences and look to see if there were differences in fathering that are related to cultural differences, including things like variation in the family systems and what fathers do in the community, Boyette said.

They hypothesized that the testosterone levels of the BaYaka men and Bondongo men were different. Testosterone, a hormone which has been shown to decrease in men when entering fatherhood in some cultural settings, can be associated with physical strength and aggression. Gettlers team hypothesized that since the BaYaka fathers place more emphasis on community and generosity, their testosterone levels will be lower than the Bondongo fathers, who are valued more for their strength and being a good resource provider.

When the researches had an opportunity to collaborate via funding from the Jacobs Foundation, Boyette said that he and Gettler jumped at the chance.

[The Jacobs Foundation] offered us this opportunity to apply for funding to work on projects together, Boyette said. It was a really fantastic opportunity and Lee and I right away saw a really good opportunity to collaborate because we both had different skill sets that we recognized would work well together.

Before the two could conduct any formal research, they had to connect with the communities and get settled.

The first summer of our grant, [Boyette] went to field site and just basically was hanging out to gain trust with the communities to talk to them about Heres what were interested in, were interested in learning about your communities and heres what we would do, Gettler said. [Boyette was] getting permission from the communities, particularly the elders and the leadership councils in the community, to make sure that they were that it was acceptable to them, ethically, that we do this work.

Boyette said that the work was challenging, and it would not have been possible without the help of others who blazed the trail for him.

Another challenge faced by the team was how to transport their materials. Gettler explained that this was an especially difficult project because they needed to transport large liquid nitrogen jugs to store saliva samples containing information about testosterone from the BaYaka and Bondongo men.

If we look at testosterone in saliva, it correlates really strongly to what is circulating in the blood in the body, but its obviously much less invasive than collecting blood so thats the benefit, Gettler mentioned. Part of the reason that there are few studies in this kind of relatively remote setting is because of the challenges of dealing with the biological markers.

Boyette explained that they had to modify their travel plans in order to transport the materials to the remote communities because the canisters of liquid nitrogen need to be closely monitored at all times to prevent spillage.

The researchers also struggled with the problem of how to quantify how the different cultures viewed fatherhood and how to decide who were the good fathers.

Gettler explained that the team conducted a series of long interviews with the villagers to get a sense of the values that were sought after in a good father.

[Boyette and his team] spent a lot of time doing semi-structured qualitative interviewswed call that data ethnography, Gettler said. Our real goal was to try to understand how these communities are defining what a good father is and then can we find a way to operationalize that to get at whether good fathers, based on local values, have healthier kids.

Once they had sorted out the cultural ideas of fatherhood, the researchers had each respective father rank each other on the main values pointed out by each community. The questions that the fathers ranked each other by varied between the BaYaka and Bondongo groups: The BaYaka cultural ranked good fathers based on how they shared resources, how hard they worked, whether they had any spousal arguments, whether their children were healthy and if they contributed to community teaching. On the other hand, the Bondongo people ranked good fathers based on fishing/hunting abilities, how big their gardens were, if they traveled to get commercial goods for the community, if they had healthy children and if they contributed to social education.

Boyette said that the different questions actually revealed a lot about the communities. He explained that they found that the Bondongo fathers were actually sorted into two groups: one of the groups of fathers focused more on the hard, laborious chores of fishing and hunting, and the other group focused on the teaching of children and staying closer to the community. As Boyette and Gettler expected, the group of Bondongo fathers that focused on the strength intensive tasks had higher levels of testosterone than the group that focused more on the children. With the BaYaka tribe who are more focused on cooperative communities, the researched noted lower levels of testosterone in men who were ranked as better fathers.

The team also noted a correlation between testosterone levels and martial arguments. They found that fathers in both communities who were rated as having more martial conflicts had higher testosterone levels.

Gettler and Boyette both agree that their study has impacts outside the remote village in the Republic of Congo. Boyette said that he believes this study shows us that there is not just one way to be a great father.

Theres not one good way that men should be contributing to their families and we have to recognize that men see themselves as coming from particular different cultural backgrounds and that these may also suit their biology better or are promoted by their biology in different ways, Boyette said. We should be able to welcome various ways of being fathers and different ways of contributing to the child development and supporting.

Here is the original post:
Notre Dame professor publishes study with new insights on fatherhood - Observer Online

In the last few years there has been more research around sexual function during the menopause transition in areas such as low libido or pain during intercourse, but very little specifically focused on how important sex is to women during this time, says Holly N. Thomas, MD, assistant professor of medicine at the University of Pittsburgh in Pennsylvania. Dr. Thomas is the lead author of research presented on the topic of the importance of sex in women as they age at the 2020 Virtual Annual Meeting of The North American Menopause Society (NAMS), which opened on September 28, 2020.

We were interested in looking at how womens ratings of how important sex was to them changes or stays the same as they move through the menopausal transition, says Thomas.

To find out the answer, investigators studied a total of 3,257 women from The Study of Womens Health Across the Nation (SWAN), all of whom completed 14 evaluations over 15 years. Visits included interviews, questionnaires, blood draws, and biometric measures such as body mass index (BMI), blood pressure levels, hormone levels, and depression symptoms.

RELATED: 10 Symptoms of Menopause and Perimenopause

Women were asked to rate how important sex was to them with the choices of not at all, not very, moderately, quite, or extremely.

Rather than look at averages of the women over time, investigators looked at trajectories within the cohort. This analysis technique allowed us to see if there are unique pathways that women can follow, explains Thomas.

If you just looked at averages of the group as a whole, it would look like how important sex is to women would go down for everyone, but what we actually found three distinct pathways women commonly follow when it comes to how much they value sex as they get older, she says.

RELATED: Masturbation 101: A Guide to Solo Sex for Women

For the largest group, about 45 percent of the women, sex did become less important to them as they went through their forties and fifties and early sixties, says Thomas. For 27 percent of the women, sex remained highly important to them throughout midlife, and for 28 percent of the women sex was not very important to them throughout the whole duration of midlife, from forties to sixties.

Its important to recognize not all women are going to follow the same pathway when it comes to sex at midlife, each woman has her own unique experience, says Thomas.

There were a few trends that Thomas and her team noticed.

These results show that its not necessarily true that sex becomes less important to all women at midlife and that its just an inevitable fact of aging, says Thomas.

RELATED: Menopause and Depression Is Strongly Linked

My takeaway was that we need to be more routinely asking women in midlife about their sexual function and whether there are barriers such as having pain during intercourse or if theyre having problems with low sexual desire thats bothering them, says Stephanie Faubion, MD, director of the Mayo Clinic Center for Womens Health in Rochester, Minnesota, and medical director of NAMS.

Sexual function is usually under addressed in women in general but certainly in women beyond menopause, adds Dr. Faubion.

RELATED:Sex Drug for Women Stirs Up Controversy in Medical Community

In general, women who have a good sex life before menopause have a good sex life after menopause, she says. This research indicates that if sex is important to a woman before menopause, its important after.

RELATED: Sexual Dysfunction in Some Women Can Occur Years Before Menopause, Study Says

Keep in mind that sex doesnt look the same with aging, says Faubion. We have to modify our expectations about sexual functioning as we get older. Sex may not be always be penis and vagina sex; I have that conversation often with my patients, she says.

As peoples bodies and health changes, including medical illnesses that can be experienced by both men and women, we may need to modify what we are doing, but nonetheless, sexual intimacy remains important to all people for as long as they live, says Faubion.

RELATED: What Is the Role of Intimacy and Sex in Overall Health?

About 30 percent or so of women in the United States report low libido or sex drive, and about 10 percent report being bothered or distressed by it, Brooke Faught, doctor of nursing practice and board-certified women's healthcare nurse practitioner, who is clinical director of the Womens Institute for Sexual Health in Nashville, Tennessee. Dr. Faught presented on sexual health, libido, and testosterone at the NAMS 2020 conference.

Having a low sex drive isnt automatically a reason for treatment; hypoactive sexual desire disorder (HSDD) is when women have a low libido and are bothered or distressed by it. If the patient isnt directly impacted or bothered by it and its not impacting their daily function, its not a true diagnosable condition, says Faught.

RELATED: The Facts About Sexual Desire Disorder (Low Libido) In Women and Men

Even when they are bothered by a lack of desire, many women put up with it rather than seek treatment; they think its a normal part of aging or something they should just deal with, she says.

One barrier that stands in the way of treating HSDD is the lack of an U.S. Food and Drug Administration (FDA)approved testosterone for women with HSDD, even though there is quite a bit of published research on how and when to use it, says Faught.

Faubion agrees, saying Testosterone is fairly well studied for sexual health in women and is effective in almost all areas of sexual function.

RELATED: Women Need Testosterone Formulation for Low Libido

The barrier that exists isnt lack of science or lack of interest, its the FDA, says Faught. The FDA has asked for more long-term data for using testosterone in hypoactive sexual desire disorder (HSDD) in women, potentially up to five years [worth], she says.

A study that would fulfill the FDAs request seems to be cost prohibitive for pharmaceutical companies, says Faught. I dont know of any specific product that is on the cusp of getting approval or seeking approval, which is unfortunate and frustrating, she adds.

There are options and guidance for how to use testosterone products for HSDD, says Faught. In 2018, the International Society for the Study of Womens Sexual Health (ISSWSH) published a process of care (POC) for the diagnosis and management of hypoactive sexual desire disorder (HSDD) in pre- and postmenopausal women, including guidelines for prescribing testosterone in postmenopausal women with HSDD.

A global consensus statement that was endorsed by several international medical societies including The International Menopause Society, The Endocrine Society, and the NAMS was published in The Journal of Clinical Endocrinology & Metabolism in October 2019. The statements purpose is to provide clear guidance on which women may benefit from testosterone therapy, as well as any potential risks.

The issue is that treating off-label can carry additional risk and expense for patients, says Faught. If I prescribe a testosterone product thats intended for men, I can prescribe it at a lower dose as is necessary, but because it isnt FDA approved for this use, usually insurance wont cover it. That could mean a cost of anywhere from $300 to $500, she says.

Compounding testosterone, a process where a pharmacist specifically makes the product from scratch may be cheaper, but then there is increased potential for human error as well as a lack of regulations, says Faught.

Probably the main reason there is no FDA-approved testosterone product for HSDD is that theres a lack of long-term safety data, says Faubion. For example, we dont know breast cancer risk, we dont know cardiovascular risk, she says.

The cardiovascular risk appears to be less of concern for women than it is for men taking testosterone, but the bigger question is breast cancer risk over time, says Faubion. This is because testosterone converts to estrogen inside the body, and so there is a question on whether that increases breast cancer risk, she says.

Ive used it in my practice and its effective for women, says Faubion. Yes, we still have questions about long-term safety and long-term efficacy, but for short-term efficacy and short-term safety, we have pretty convincing data; I think ultimately it probably will be approved for use in women.

RELATED:Menopause and Sleep News: NAMS 2020 Addresses 5 Key Issues;

Hot Flash Treatment News: 4 Takeaways From NAMS 2020

Read more:
Sex Life, Sex Drive, and Menopause: News from NAMS 2020 - Everyday Health

LOS ANGELES, United States: QY Research has recently published a research report titled, Global Testosterone Replacement Therapy Market Size, Manufacturers, Supply Chain, Sales Channel and Clients, 2020-2026. This report has been prepared by experienced and knowledgeable market analysts and researchers. It is a phenomenal compilation of important studies that explore the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the global Testosterone Replacement Therapy market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Testosterone Replacement Therapy market.

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Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Testosterone Replacement Therapy market.

Key questions answered in the report:

TOC

1 Study Coverage1.1 Testosterone Replacement Therapy Product Introduction1.2 Market by Type1.2.1 Global Testosterone Replacement Therapy Market Size Growth Rate by Type1.2.2 Gels1.2.3 Injections1.2.4 Patches1.2.5 Other1.3 Market by Application1.3.1 Global Testosterone Replacement Therapy Market Size Growth Rate by Application1.3.2 Hospitals1.3.3 Clinics1.3.4 Others1.4 Study Objectives1.5 Years Considered 2 Executive Summary2.1 Global Testosterone Replacement Therapy Market Size Estimates and Forecasts2.1.1 Global Testosterone Replacement Therapy Revenue 2015-20262.1.2 Global Testosterone Replacement Therapy Sales 2015-20262.2 Testosterone Replacement Therapy Market Size by Region: 2020 Versus 20262.3 Testosterone Replacement Therapy Sales by Region (2015-2026)2.3.1 Global Testosterone Replacement Therapy Sales by Region: 2015-20202.3.2 Global Testosterone Replacement Therapy Sales Forecast by Region (2021-2026)2.3.3 Global Testosterone Replacement Therapy Sales Market Share by Region (2015-2026)2.4 Testosterone Replacement Therapy Market Estimates and Projections by Region (2021-2026)2.4.1 Global Testosterone Replacement Therapy Revenue by Region: 2015-20202.4.2 Global Testosterone Replacement Therapy Revenue Forecast by Region (2021-2026)2.4.3 Global Testosterone Replacement Therapy Revenue Market Share by Region (2015-2026) 3 Global Testosterone Replacement Therapy by Manufacturers3.1 Global Top Testosterone Replacement Therapy Manufacturers by Sales3.1.1 Global Testosterone Replacement Therapy Sales by Manufacturer (2015-2020)3.1.2 Global Testosterone Replacement Therapy Sales Market Share by Manufacturer (2015-2019)3.2 Global Top Testosterone Replacement Therapy Manufacturers by Revenue3.2.1 Global Testosterone Replacement Therapy Revenue by Manufacturer (2015-2020)3.2.2 Global Testosterone Replacement Therapy Revenue Share by Manufacturer (2015-2020)3.3 Global Testosterone Replacement Therapy Price by Manufacturer (2015-2020)3.4 Competitive Landscape3.4.1 Key Testosterone Replacement Therapy Manufacturers Covered: Ranking by Revenue3.4.2 Global Testosterone Replacement Therapy Market Concentration Ratio (CR5 and HHI) & (2015-2020)3.4.3 Global Testosterone Replacement Therapy Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.5 Global Testosterone Replacement Therapy Manufacturing Base Distribution, Product Type3.5.1 Testosterone Replacement Therapy Manufacturers Manufacturing Base Distribution, Headquarters3.5.2 Manufacturers Testosterone Replacement Therapy Product Type3.5.3 Date of International Manufacturers Enter into Testosterone Replacement Therapy Market3.6 Manufacturers Mergers & Acquisitions, Expansion Plans 4 Company Profiles4.1 AbbVie4.1.1 AbbVie Corporation Information4.1.2 AbbVie Description, Business Overview4.1.3 AbbVie Testosterone Replacement Therapy Products Offered4.1.4 AbbVie Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.1.5 AbbVie Testosterone Replacement Therapy Revenue by Product4.1.6 AbbVie Testosterone Replacement Therapy Revenue by Application4.1.7 AbbVie Testosterone Replacement Therapy Revenue by Geographic Area4.1.8 AbbVie Testosterone Replacement Therapy Revenue by Sales Channel4.1.9 AbbVie Recent Development4.2 Endo International4.2.1 Endo International Corporation Information4.2.2 Endo International Description, Business Overview4.2.3 Endo International Testosterone Replacement Therapy Products Offered4.2.4 Endo International Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.2.5 Endo International Testosterone Replacement Therapy Revenue by Product4.2.6 Endo International Testosterone Replacement Therapy Revenue by Application4.2.7 Endo International Testosterone Replacement Therapy Revenue by Geographic Area4.2.8 Endo International Testosterone Replacement Therapy Revenue by Sales Channel4.2.9 Endo International Recent Development4.3 Eli lilly4.3.1 Eli lilly Corporation Information4.3.2 Eli lilly Description, Business Overview4.3.3 Eli lilly Testosterone Replacement Therapy Products Offered4.3.4 Eli lilly Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.3.5 Eli lilly Testosterone Replacement Therapy Revenue by Product4.3.6 Eli lilly Testosterone Replacement Therapy Revenue by Application4.3.7 Eli lilly Testosterone Replacement Therapy Revenue by Geographic Area4.3.8 Eli lilly Testosterone Replacement Therapy Revenue by Sales Channel4.3.9 Eli lilly Recent Development4.4 Pfizer4.4.1 Pfizer Corporation Information4.4.2 Pfizer Description, Business Overview4.4.3 Pfizer Testosterone Replacement Therapy Products Offered4.4.4 Pfizer Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.4.5 Pfizer Testosterone Replacement Therapy Revenue by Product4.4.6 Pfizer Testosterone Replacement Therapy Revenue by Application4.4.7 Pfizer Testosterone Replacement Therapy Revenue by Geographic Area4.4.8 Pfizer Testosterone Replacement Therapy Revenue by Sales Channel4.4.9 Pfizer Recent Development4.5 Actavis (Allergan)4.5.1 Actavis (Allergan) Corporation Information4.5.2 Actavis (Allergan) Description, Business Overview4.5.3 Actavis (Allergan) Testosterone Replacement Therapy Products Offered4.5.4 Actavis (Allergan) Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.5.5 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Product4.5.6 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Application4.5.7 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Geographic Area4.5.8 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Sales Channel4.5.9 Actavis (Allergan) Recent Development4.6 Bayer4.6.1 Bayer Corporation Information4.6.2 Bayer Description, Business Overview4.6.3 Bayer Testosterone Replacement Therapy Products Offered4.6.4 Bayer Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.6.5 Bayer Testosterone Replacement Therapy Revenue by Product4.6.6 Bayer Testosterone Replacement Therapy Revenue by Application4.6.7 Bayer Testosterone Replacement Therapy Revenue by Geographic Area4.6.8 Bayer Recent Development4.7 Novartis4.7.1 Novartis Corporation Information4.7.2 Novartis Description, Business Overview4.7.3 Novartis Testosterone Replacement Therapy Products Offered4.7.4 Novartis Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.7.5 Novartis Testosterone Replacement Therapy Revenue by Product4.7.6 Novartis Testosterone Replacement Therapy Revenue by Application4.7.7 Novartis Testosterone Replacement Therapy Revenue by Geographic Area4.7.8 Novartis Recent Development4.8 Teva4.8.1 Teva Corporation Information4.8.2 Teva Description, Business Overview4.8.3 Teva Testosterone Replacement Therapy Products Offered4.8.4 Teva Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.8.5 Teva Testosterone Replacement Therapy Revenue by Product4.8.6 Teva Testosterone Replacement Therapy Revenue by Application4.8.7 Teva Testosterone Replacement Therapy Revenue by Geographic Area4.8.8 Teva Recent Development4.9 Mylan4.9.1 Mylan Corporation Information4.9.2 Mylan Description, Business Overview4.9.3 Mylan Testosterone Replacement Therapy Products Offered4.9.4 Mylan Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.9.5 Mylan Testosterone Replacement Therapy Revenue by Product4.9.6 Mylan Testosterone Replacement Therapy Revenue by Application4.9.7 Mylan Testosterone Replacement Therapy Revenue by Geographic Area4.9.8 Mylan Recent Development4.10 Upsher-Smith4.10.1 Upsher-Smith Corporation Information4.10.2 Upsher-Smith Description, Business Overview4.10.3 Upsher-Smith Testosterone Replacement Therapy Products Offered4.10.4 Upsher-Smith Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.10.5 Upsher-Smith Testosterone Replacement Therapy Revenue by Product4.10.6 Upsher-Smith Testosterone Replacement Therapy Revenue by Application4.10.7 Upsher-Smith Testosterone Replacement Therapy Revenue by Geographic Area4.10.8 Upsher-Smith Recent Development4.11 Ferring Pharmaceuticals4.11.1 Ferring Pharmaceuticals Corporation Information4.11.2 Ferring Pharmaceuticals Description, Business Overview4.11.3 Ferring Pharmaceuticals Testosterone Replacement Therapy Products Offered4.11.4 Ferring Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.11.5 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Product4.11.6 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Application4.11.7 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Geographic Area4.11.8 Ferring Pharmaceuticals Recent Development4.12 Kyowa Kirin4.12.1 Kyowa Kirin Corporation Information4.12.2 Kyowa Kirin Description, Business Overview4.12.3 Kyowa Kirin Testosterone Replacement Therapy Products Offered4.12.4 Kyowa Kirin Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.12.5 Kyowa Kirin Testosterone Replacement Therapy Revenue by Product4.12.6 Kyowa Kirin Testosterone Replacement Therapy Revenue by Application4.12.7 Kyowa Kirin Testosterone Replacement Therapy Revenue by Geographic Area4.12.8 Kyowa Kirin Recent Development4.13 Acerus Pharmaceuticals4.13.1 Acerus Pharmaceuticals Corporation Information4.13.2 Acerus Pharmaceuticals Description, Business Overview4.13.3 Acerus Pharmaceuticals Testosterone Replacement Therapy Products Offered4.13.4 Acerus Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.13.5 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Product4.13.6 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Application4.13.7 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Geographic Area4.13.8 Acerus Pharmaceuticals Recent Development 5 Breakdown Data by Type5.1 Global Testosterone Replacement Therapy Sales by Type (2015-2026)5.1.1 Global Testosterone Replacement Therapy Sales by Type (2015-2020)5.1.2 Global Testosterone Replacement Therapy Sales Forecast by Type (2021-2026)5.1.3 Global Testosterone Replacement Therapy Sales Market Share by Type (2015-2026)5.2 Global Testosterone Replacement Therapy Revenue Forecast by Type (2015-2026)5.2.1 Global Testosterone Replacement Therapy Revenue by Type (2015-2020)5.2.2 Global Testosterone Replacement Therapy Revenue Forecast by Type (2021-2026)5.2.3 Global Testosterone Replacement Therapy Revenue Market Share by Type (2015-2026)5.3 Testosterone Replacement Therapy Average Selling Price (ASP) by Type (2015-2026) 6 Breakdown Data by Application6.1 Global Testosterone Replacement Therapy Sales by Application (2015-2026)6.1.1 Global Testosterone Replacement Therapy Sales by Application (2015-2020)6.1.2 Global Testosterone Replacement Therapy Sales Forecast by Application (2021-2026)6.1.3 Global Testosterone Replacement Therapy Sales Market Share by Application (2015-2026)6.2 Global Testosterone Replacement Therapy Revenue Forecast by Application (2015-2026)6.2.1 Global Testosterone Replacement Therapy Revenue by Application (2015-2020)6.2.2 Global Testosterone Replacement Therapy Revenue Forecast by Application (2021-2026)6.2.3 Global Testosterone Replacement Therapy Revenue Market Share by Application (2015-2026)6.3 Testosterone Replacement Therapy Average Selling Price (ASP) by Application (2015-2026) 7 North America7.1 North America Testosterone Replacement Therapy Market Size YoY Growth 2015-20267.2 North America Testosterone Replacement Therapy Market Facts & Figures by Country7.2.1 North America Testosterone Replacement Therapy Sales by Country (2015-2026)7.2.2 North America Testosterone Replacement Therapy Revenue by Country (2015-2026)7.3 North America Testosterone Replacement Therapy Sales by Type7.4 North America Testosterone Replacement Therapy Sales by Application 8 Asia-Pacific8.1 Asia-Pacific Testosterone Replacement Therapy Market Size YoY Growth 2015-20268.2 Asia-Pacific Testosterone Replacement Therapy Market Facts & Figures by Region8.2.1 Asia-Pacific Testosterone Replacement Therapy Sales by Region (2015-2026)8.2.2 Asia-Pacific Testosterone Replacement Therapy Revenue by Region (2015-2026)8.3 Asia-Pacific Testosterone Replacement Therapy Sales by Type8.4 Asia-Pacific Testosterone Replacement Therapy Sales by Application 9 Europe9.1 Europe Testosterone Replacement Therapy Market Size YoY Growth 2015-20269.2 Europe Testosterone Replacement Therapy Market Facts & Figures by Country9.2.1 Europe Testosterone Replacement Therapy Sales by Country (2015-2026)9.2.2 Europe Testosterone Replacement Therapy Revenue by Country (2015-2026)9.3 Europe Testosterone Replacement Therapy Sales by Type9.4 Europe Testosterone Replacement Therapy Sales by Application 10 Latin America10.1 Latin America Testosterone Replacement Therapy Market Size YoY Growth 2015-202610.2 Latin America Testosterone Replacement Therapy Market Facts & Figures by Country10.2.1 Latin America Testosterone Replacement Therapy Sales by Country (2015-2026)10.2.2 Latin America Testosterone Replacement Therapy Revenue by Country (2015-2026)10.3 Latin America Testosterone Replacement Therapy Sales by Type10.4 Latin America Testosterone Replacement Therapy Sales by Application 11 Middle East and Africa11.1 Middle East and Africa Testosterone Replacement Therapy Market Size YoY Growth 2015-202611.2 Middle East and Africa Testosterone Replacement Therapy Market Facts & Figures by Country11.2.1 Middle East and Africa Testosterone Replacement Therapy Sales by Country (2015-2026)11.2.2 Middle East and Africa Testosterone Replacement Therapy Revenue by Country (2015-2026)11.3 Middle East and Africa Testosterone Replacement Therapy Sales by Type11.4 Middle East and Africa Testosterone Replacement Therapy Sales by Application 12 Supply Chain and Sales Channel Analysis12.1 Testosterone Replacement Therapy Supply Chain Analysis12.2 Testosterone Replacement Therapy Key Raw Materials and Upstream Suppliers12.3 Testosterone Replacement Therapy Clients Analysis12.4 Testosterone Replacement Therapy Sales Channel and Sales Model Analysis12.4.1 Testosterone Replacement Therapy Distribution Channel Analysis: Indirect Sales VS Direct Sales12.4.2 Testosterone Replacement Therapy Distribution Channel Analysis: Online Sales VS Offline Sales12.4.3 Testosterone Replacement Therapy Distributors 13 Market Dynamics13.1 Testosterone Replacement Therapy Market Drivers13.2 Testosterone Replacement Therapy Market Opportunities13.3 Testosterone Replacement Therapy Market Challenges13.4 Testosterone Replacement Therapy Market Restraints13.5 Porters Five Forces Analysis 14 Research Findings and Conclusion 15 Appendix15.1 Research Methodology15.1.1 Methodology/Research Approach15.1.2 Data Source15.2 Author Details15.3 Disclaimer

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Testosterone Replacement Therapy Market size was US$ 1665.5 million and it is expected to reach US$ 1238.2 million by the end of 2026, with a CAGR of...

Contrary to prior understanding, many hormones related to spermatogenesis take longer to recover than previously thought, and up to 3 years in some cases after anabolic steroid misuse, according to a fertility expert speaking at the Royal Society of Medicine webinar series.

Dr Channa Jayasena, consultant in reproductive endocrinology and andrology at Imperial College and Hammersmith Hospital, London, gave a talk on male hypogonadism that he admitted might seem provocative to some people but addresses issues that extend current knowledge. The three key issues discussed were: how quickly can men recover fertility after androgen use; how to assist azoospermic men with Klinefelter syndrome (or XXY) father children; and whether testosterone therapy affects progression to diabetes in obese men.

Dr Jayasena spoke at last weeks 3-day webinar held by the Royal Society of Medicine, Endocrinology and Diabetes section, entitled, EDN50:What's new in endocrinology and diabetes 2020?

He began by asking how quicky do men who take anabolic steroids recover fertility? "This has never been studied to much extent."

Self-confessed steroid user and reality television star, Spencer Matthews, said in a tabloid newspaper article that the UK is in the grips of an epidemic of anabolic steroid use, Dr Jayasena remarked. "I see men who take anabolic steroids but then they want a baby and want to know whats next?"

The nearest data to understanding recovery from anabolic steroids comes from studies of the male pill, said the andrologist. This involves giving a high level of progesterone to suppress luteinising hormone and follicle stimulating hormone (in effect the male pill), and then giving the men testosterone replacement. A Lancet paper (Liu at al 2006) involving this regimen looked at the time from stopping the male pill to recovery of sperm. It shows that, by 12 months, all participants had recovered some sperm function, with 80% recovering to the pre-treatment semen level, explained Dr Jayasena. "This has long been presumed to be the measure of recovery. However, this does not resonate with reality and the observation that actually there are many people who dont recover within this time frame and take a lot longer, some with azoospermia[semen containing no sperm]," he pointed out.

Another cross-sectional observational study looked at 41 current users of anabolic steroids, 31 recent ( 3 months since last use), and 21 healthy eugonadal men. All were 18-55 years, exercising at least three times a week. "The critical strength of this study is that these men were all clinically indistinct," Dr Jayasena remarked. "This matching of baseline characteristics is critical for interpretation of the data. Due to recruitment issues, weve never had such a good look at recovery in this way before."

The study looked at the reproductive endocrine profiles including the levels of luteinising hormone, follicle stimulating hormone, and testosterone. In current users, the former two were suppressed and the testosterone level was high, as expected, displaying a hypogonadatropic profile. "Past users and non-users have very similar profiles, suggesting reversible luteinising hormone and follicle stimulating hormone suppression," said Dr Jayasena, adding, "this is really interesting and looking at acne, gynaecomastia, hair loss and smaller testicles all classical features of androgen abuse - appear to persist in many of the men who are past users. Its important we counsel these men that we, the clinicians, are not really clear about how long these side effects will persist."

Results also showed low HDL cholesterol and high triglycerides in users, but not in non-users or past users, and cardiac hypertrophy in users but not past users. "The latter finding is encouraging," Dr Jayasena pointed out.

Regarding fertility, the study by Shankara-Naranya found that when comparing non-users to users of anabolic steroids, it took a mean of 10.7 months for users to recover their luteinising hormone levels to the mean luteinising hormone of a non-user. "But recovery time is highly variable. Luteinising hormone (and testosterone by inference), and sperm concentration seem to recover within a year, with a mean of 10 months, but all the other hormones that are important for spermatogenesis take much longer to recover so follicle stimulating hormone was 20 months, inhibin B was 32 months, sperm motility was 38 months, up to 3 years to recover. This is critical and we didnt know this," reported Dr Jaysena.

"In answer to what is the prognosis for recovery in men after androgen misuse? The endocrine system mostly recovers in the first year but sperm take much longer to recover," he concluded.

Along with Downs syndrome, Klinefelter is the most common chromosomal disorder in men, affecting 1 in 500 men. A total of 90% of those with Klinefelter syndrome are azoospermic, and it has long been assumed to be incompatible with fatherhood.

"Things have changed, and Id like to ask what is the chance of fatherhood for a man with XXY undergoing microdissection testicular sperm extraction (mTESE)?" said Dr Jayasena. "This can be done by dissecting open a testicle and looking for an engorged seminiferous tubule that is likely to be full of sperm," he explained. "If this is confirmed, after some processing, the sperm can be used in intracytoplasmicsperm injection (ICSI)."

It has been known that it was possible for patients with Klinefelter syndrome to father children for the past 20 years, but, asked Dr Jayasena, how successful is it? "Its still an embryonic field," he noted. Referring to a meta-analysis of 37 studies, Dr Jayasena said 40% of men with Klinefelters syndrome had sperm retrieved, and of these 40%, an average of nearly 50% of men had live births after ICSI. But some studies reported 10% and others 90%.

In conclusion, the chances of fatherhood in XXY men undergoing mTESE, is around 20% but a large randomised controlled trial (RCT) is needed to confirm this, said Dr Jayasena.

Finally, the researcher moved on to the third topic of whether testosterone therapy improves the effectiveness of weight loss in men over 50 years with type 2 diabetes. Referring to outcomes of the largest, as yet unpublished, testosterone trial ever, in more than 1000 men by Dr Gary Wittert, from the University of Adelaide, Dr Jayasena described the study.

Most importantly, they did not select men with hypogonadism these results are not valid for hypogonadism because not all men had hypogonadism, explained Dr Jayasena. Two-hour plasma glucose was 7.8 to 15 mmol/l. The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosterone. They also excluded men with high cardiovascular risk, due to a Food and Drug Administration [FDA] unproven concern about cardiovascular risk. "Testosterone may be dangerous in some of these men (59-75 years and obese) in real life," he pointed out.

The paper is currently in review but some preliminary findings were presented at a conference earlier this year. Dr Jayasena says: "If testosterone improves the prevention of type 2 diabetes during weight loss in men without hypogonadism, then that would challenge our understanding of how it works. However, testosterone is still not a treatment to prevent type 2 diabetes,"

To answer the question definitively, said Dr Jayasena, confirmatory data, mechanistic data, and safety data are needed.

COI: Dr Jayasena received an honorarium for speaking during a debate organised by the Society for Endocrinology and sponsored by Besins Healthcare. He has an investigator-led grant by Logixx Pharma Ltd.

Presented at the Royal Society of Medicine, Endocrinology and Diabetes section, entitled, EDN50: What's new in endocrinology and diabetes 2020? , Day 3. September 23, 2020

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Sperm Take Up to 3 Years to Recover After Anabolic Steroids - Medscape

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Testosterone Replacement Therapy Market Potential Growth, Size, Share, Demand and Analysis of Key Players Research Forecasts to 2027 - The Daily...

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Prominent Key Players Covered in the report:

AbbVie Inc., Bausch Health Companies Inc., Allergan, Amneal Pharmaceuticals LLC, Pfizer Inc., Endo International plc, Teva Pharmaceutical Industries Ltd., Perrigo Company plc, Cipla Inc., Lupin, Novartis AG, Sun Pharmaceuticals Industries Ltd., Hikma Pharmaceuticals PLC, among others.

Major Regions as Follows:

A complete value chain of the global Testosterone Replacement Therapy market is presented in the research report. It is associated with the review of the downstream and upstream components of the Testosterone Replacement Therapy Market. The market is bifurcated on the basis of the categories of products and customer application segments. The market analysis demonstrates the expansion of each segment of the global Testosterone Replacement Therapy market. The research report assists the user in taking a decisive step that will be a milestone in developing and expanding their businesses in the global Testosterone Replacement Therapy market.

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TABLE OF CONTENTS

Part 01:Executive Summary

Part 02:Scope of the Report

Part 03:Research Methodology

Part 04:Market Landscape

Part 05:Pipeline Analysis

Part 06:Market Sizing

Market Definition

Market Sizing

Market Size And Forecast

Part 07:Five Forces Analysis

Bargaining Power Of Buyers

Bargaining Power Of Suppliers

Threat Of New Entrants

Threat Of Substitutes

Threat Of Rivalry

Market Condition

Part 08:Market Segmentation

Segmentation

Comparison

Market Opportunity

Part 09:Customer Landscape

Part 10:Regional Landscape

Part 11:Decision Framework

Part 12:Drivers and Challenges

Part 13:Market Trends

Part 14:Vendor Landscape

Part 15:Vendor Analysis

Vendors Covered

Vendor Classification

Market Positioning Of Vendors

Part 16:Appendix

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Massive Growth Of Testosterone Replacement Therapy Market Size Strong Revenue and Competitive Outlook - The Daily Chronicle

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