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According to Persistence Market Researchs new report, global male hypogonadism market is slated to exhibit a steady expansion throughout the forecast period (2017-2026). Revenues from the global market for male hypogonadism are estimated to exceed US$ 3,300 Mn by 2026-end.

According to Persistence Market Researchs new report, globalmale hypogonadism marketis slated to exhibit a steady expansion throughout the forecast period (2017-2026). Revenues from the global market for male hypogonadism are estimated to exceed US$ 3,300 Mn by 2026-end.

Governments Taking Initiatives to Spread Awareness about Male Hypogonadism Therapeutics

Lack of sex hormones, usually referred to as male hypogonadism has resulted into many health risks that include osteoporosis, heart disease, and cardiovascular diseases on the back of thinning of bones. Global male hypogonadism market comprises several patented brands that currently have high market penetration. Proliferation in geriatric population in tandem with rising incidences related to rheumatoid arthritis and obesity have been primary factors affecting prevalence of male hypogonadism globally.

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Company Profiles

Mounting incidences of testosterone deficiency in male population is a key factor that prevalence of male hypogonadism has surged worldwide. Several governments around the world have been taking initiatives to spread the awareness on hypogonadism treatment procedures, for example - testosterone replacement therapy (TST), in order to relieve the painful burden on patients and their families.

As low testosterone levels are increasingly associated with exacerbation of chronic conditions, it further results into disorders apropos to hypothalamic-pituitary-gonadal axis. Advent of TST has however enabled reduction in cases of male hypogonadism considerably. With growing awareness related to its treatment among patients, the market is likely to gain an uptick during the forecast period.

Rising availability of the selective androgen receptor modulators (SARMs) has further sustained the market expansion. The development and high availability of SARMs has led toward the provision of improved treatment procedure to patients having androgen deficiencies, thereby influencing the market growth.

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North America will continue to Dominate Global Male Hypogonadism Market

North America will continue to dominate the global male hypogonadism market, with more than one-third revenue share during the forecast period. In addition, revenues from the male hypogonadism market in North America will exhibit the fastest expansion through 2026, as compared to those from all the other regional segments comprised in the report. Europe and Asia-Pacific excluding Japan (APEJ) are also expected to remain lucrative for the male hypogonadism market. The market in APEJ will ride on a slightly higher CAGR than that in Europe through 2026.

Topical gels are expected to remain the most lucrative among drugs available for treatment of male hypogonadism globally, with sales projected to register the fastest expansion through 2026. Injectables will also remain a major revenue contributor to the market. Sales of injectable and transdermal patches are poised to reflect an equal CAGR through 2026.

Testosterone Replacement Therapy to Remain Preferred among Patients

Based on therapy, testosterone replacement therapy is expected to remain preferred among patients with male hypogonadism worldwide. Roughly 66% revenue share of the market is expected to be held by revenues from testosterone replacement therapy by 2026-end. Revenues from gonadotropin replacement therapy will remain slightly more than half revenues gained from testosterone replacement therapy throughout the forecast period.

Klinefelters syndrome is expected to remain the most prevalent disease type observed in the male hypogonadism market, and revenues from treatment of this disease will exceed US$ 1,800 Mn by 2026-end. Kallmann Syndrome and Pituitary Adenomas among disease types will also account for major revenue shares of the market by 2026-end.

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Consumers Opting For To Help The Male Hypogonadism Market Cross US$ 3,300 Mn Between 2026 - Industry Today

Scientists have uncovered an enzyme that appears to play a key role in regulating sexual behavior in males. Their new research, published in the journal Endocrinology, found that selectively disrupting the enzyme aromatase in the brains of male mice led to a sharp decrease in sexual behavior.

Over the past 30 years, we have been interested in various roles of aromatase, the enzyme that produces estrogen from testosterone locally in a number of body sites including the brain, explained Serdar Bulun, the chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Medicine.

There have been a number of reports about the function of aromatase in specific brain regions for sexually dimorphic brain development particularly in males during fetal development and early postnatal life; and sparse data also suggested that the aromatization of testosterone to estrogen in the brain might play a role in regulating libido, but this remained as an important question in the adult male.

There was a definitive way to answer this question: to knock out aromatase selectively in the brain and find out if sexual activity or desire changes. This is what we did, Bulun said.

The researchers found that sexual activity in male mice decreased by 50% when they knocked out a single gene responsible for encoding the enzyme, despite the mice having higher levels of blood testosterone levels (compared with control male mice).

Normally, if a male mouse is put with a female one, Bulun said in a news release, it would chase after her and try to have sex with her. If you knock out the aromatase gene in the brain, their sexual activity is significantly reduced. There is less frequency of mating. The male mice are not that interested.

The decreased sexual behavior in male mice was fully restored after the systemic administration of both estradiol and testosterone but not by estradiol or testosterone alone. This indicates that the conversion of testosterone to estrogen in the brain plays an important role in male sexual behavior, the researchers said.

Estrogen and testosterone have been traditionally labeled as female and male sex steroids, respectively. Our findings underscore that this is a superficial characterization. Both steroids serve important roles in both sexes, Bulun told PsyPost.

Testosterone in the brain serves two purposes for sexual desire. As an androgen, it stimulates it. As a further twist, testosterone is also aromatized and thus serves as a precursor for estrogen in the brain.

This additional estrogenic effect in the brain is necessary for achieving full sexual desire. Because males (versus females) have enormously higher levels of blood testosterone, they can concentrate estrogen in certain brain regions much more effectively compared with females. We hope that our findings will help design treatments for the disorders involving sexual desire, Bulun said.

But the researchers still have more to learn about the relationship between aromatase and sexual behavior.

We knocked out aromatase in the entire brain. Aromatase in the adult brain is present in specific locations such as the hypothalamus, amygdala and several other regions. We still need to pinpoint the microscopic brain regions responsible for controlling libido via more refined conditional knockout technology, Bulun explained.

There also remain other key questions. How does estrogen regulate sexual desire? What are the downstream neurotransmitters that mediate this estrogenic effect? How do aromatase-intense regions communicate with the cortex to regulate sexual activity?

The study, Brain Aromatase and the Regulation of Sexual Activity in Male Mice, was authored by David C. Brooks, John S. Coon V., Cihangir M. Ercan, Xia Xu, Hongxin Dong, Jon E. Levine, Serdar E. Bulun, and Hong Zhao.

Continued here:
New research suggests the conversion of testosterone to estrogen in the brain is crucial for male sexual d ... - PsyPost

PHILADELPHIA - Exposure to hydraulic fracturing fluid in drinking water has been shown to increase the risk of respiratory problems, premature births, congenital heart defects, and other medical problems. But not all wells are created equal. Since different hydraulic fracturing -- or fracking -- sites use a diverse mix of chemical ingredients, often individuals and researchers are in the dark about the health consequences of living near a particular well.

Now, a new, interactive tool created by Penn Medicine researchers allows community members and scientists to find out which toxins may be lurking in their drinking water as a result of fracking. By typing your ZIP code into the website or accompanying app -- called WellExplorer -- you can view the closest fracking sites in your state, learn which chemicals are used at those sites, and view their levels of toxicity.

In a recent study, published in Database: The Journal of Biological Databases and Curation, the WellExplorer app's creators found, for example, that wells in Alabama use a disproportionately high number of ingredients targeting estrogen pathways, while Illinois, Ohio, and Pennsylvania use a high number of ingredients targeting testosterone pathways. The information found through WellExplorer might be particularly relevant for individuals who use private water wells, which are common in rural Pennsylvania, since homeowners may not be performing rigorous testing for these fracking chemicals, according to the study's principal investigator Mary Regina Boland, PhD, an assistant professor of Informatics in the Perelman School of Medicine at the University of Pennsylvania.

"The chemical mixtures used in fracking are known to regulate hormonal pathways, including testosterone and estrogen, and can therefore affect human development and reproduction," Boland said. "Knowing about these chemicals is important, not only for researchers who may be studying health outcomes in a community, but also for individuals who may want to learn more about possible health implications based on their proximity to a well. They can then potentially have their water tested."

While FracFocus.org serves as a central registry for fracking chemical disclosures in the United States, the database is not user-friendly for the general public, and it does not contain information about the biological action of the fracking chemicals that it lists. In order to create a tool that could provide more in-depth, functional information for researchers and individuals alike, the Penn researchers first cleaned, shortened, and subsetted the data from FracFocus.org to create two newly usable files that could be in used in WellExplorer website and app.

Because the research team also wanted to provide toxic and biological properties of the ingredients found at these well sites, they integrated data from the Toxin and Toxin Target Database (T3DB). From that database, they compiled information on fracking chemicals' protein targets (and the genes that encode those proteins), toxin mechanisms of actions, and specific protein functions. Moreover, they extracted the toxicity rankings of the top 275 most toxic ingredients from the Agency for Toxic Substances and Disease Registry, as well as a list of ingredients that were food additives as described by Substances Added to Food Inventory. The team then linked all of that information together and created a ZIP Searcher function into their web tool, so that people could easily find their exposure risks to specific chemicals.

"The information had been out there, but it was not all linked together in a way that's easy for regular people to use," Boland said.

However, Boland added that the use of chemicals at a fracking site may not necessarily mean that those chemicals would be present in the water supply, which would be dependent on other factors, such as what type of soil or bedrock is being drilled into, and the depth of both the hydraulic fracturing well and an individual's private well depth. Nonetheless, WellExplorer provides a starting point for residents who may be experiencing symptoms and want to have their water tested.

Beyond information-gathering for individuals, WellExplorer can also be used as an important tool for environmental scientists, epidemiologists, and other researchers to make connections between specific health outcomes and proximity to a specific fracturing well. From a development standpoint, this means that the research team had to be conscious of the two audiences when designing the website and app, said Owen Wetherbee, who aided in the development of WellExplorer while interning in the Boland Lab.

"Nationally, researchers are trying to link fracking to health outcomes, and I believe that a large reason why answering that question is challenging, is because different wells are using different ingredients, and so, the side effects of exposure would be different from place to place," Boland added. "What this app gives you is some information about where to start looking for these answers."

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Is your drinking water toxic? This app may help you find out - Science Codex

Humans aren't the only species that are preparing for the cold weather - as temperatures begin to ... [+] drop, West Indian manatees make the journey inland to Florida's warm natural springs.

Editors Note: *Due to the current Covid-19 outbreak, the potential complications that may arise from recreational travel should not be taken lightly - it is recommended to thoroughly inspectCDC guidelinesbefore making any travel plans.*

Marked by crisp air and the return of the pumpkin spice latte, the weeks of early autumn are celebrated worldwide as endless opportunities for leaf peeping arise - but theres far more to the season than simply colorful foliage. All throughout the natural world, flora and fauna take notice of the changing temperature, embarking on mass migrations and vibrant blooms that are truly spectacular to behold. For an opportunity to spot creatures from all walks of life, ranging from tiny wildflowers to the largest mammals on earth, take a look at the activities listed below.

The American Oystercatcher is just one of many shorebirds to be encountered on the coast of Cape ... [+] May.

While the historic seaside city of Cape May draws tens of thousands of beachgoers during the summer months, birdwatching fosters a surge in tourism as the weather begins to cool. All throughout October, visitors to the southernmost point of New Jersey can witness hundreds of migratory avian species, ranging from colorful songbirds to sleek raptors. Home to lush wetlands and rolling sand dunes, the pristine South Cape May Meadows are a great destination to view a diverse array of hawk species, while nearby Stone Harbor Point is rife with wading shorebirds, brown pelicans, and the occasional peregrine falcon.

During rutting season, bull elk often engage in physical combat, rushing towards each other and ... [+] slamming their antlers together until one concedes.

While cold weather and crimson foliage are two hallmarks of early autumn, those who live around the Rockies may be familiar with a third - the haunting bugle of a bull elk, ringing out for miles during peak rutting season. This natural phenomenon is marked by a major hormonal change in male elks, with increased testosterone flooding their veins as they battle one another for a chance to mate with the areas most eligible bachelorettes. Theres a wide array of destinations across the Rockies to witness the rut, including Rocky Mountain National Park or the iconic Yellowstone, but wherever you go, just be sure to keep a safe distance - a 700-pound bull elk on a testosterone bender is nothing to mess around with.

While these colorful flowers are often referred to as daisies, this species (Helianthus porteri) is ... [+] actually a relative of the sunflower.

Located just half an hour east of downtown Atlanta, the 40,000-acre Arabia Mountain National Heritage Area has undergone a drastic transformation, with huge swathes of daisies painting the typically-barren granite landscape with a brilliant yellow hue. This year, the preserve is celebrating Septembers Daisy Days with an exciting competition perfectly suited for outdoor adventurers: the Triple Hike Challenge. All throughout the month, visitors are encouraged to scale Stone Mountain, Panola Mountain, and Arabia Mountain, snapping a photo of each one as they reach the summit. Those who complete their mission will receive a special prize to be revealed later, but dont hesitate - this contest ends on the last day of the month.

Massachusetts is a particularly popular destination for whalewatching - this hungry humpback was ... [+] spotted off the coast of Provincetown, a community on the tip of Cape Cod.

A region that was once heavily involved in the whaling industry, New Englands seaside towns and cities have set aside the harpoons in favor of cameras and microphones, offering spectacular excursions to spot some of the oceans most gentle creatures. While peak whale watching season runs from April to October, an autumn visit allows visitors to kill two birds with one stone, immersing themselves in vibrant fall foliage alongside humpbacks, finbacks, minke whales, and right whales. Serious nature enthusiasts should consider a trip to coastal Maine, spending a day on the sea with Bar Harbor Whale Watch Co followed by a day of exploring iconic Acadia National Park, one of New Englands most esteemed destinations for leaf peeping.

While one may assume that manatees are related to seals or whales, the closest living relative of ... [+] these gentle creatures is the elephant.

After months spent roaming the coast, the cooling temperatures of early autumn begin to drive manatees back to the rivers of Florida, packing the state with huge populations of these iconic mammals. Manatee viewing season peaks in the dead of winter, but those who get an early start in autumn can spot some of the years early movers without the hassle of huge crowds, providing an intimate viewing experience thats tough to recreate once the season really kicks in. Your best bet for spotting manatees in the early season is Crystal River - this area is rife with natural springs that create a safe haven for the gentle beasts, with year-round populations calling the waterways home.

More here:
5 Natural Wonders Of The US To Experience In Early Autumn - Forbes

Male infertility refers the male inability to cause pregnancy in a fertile female. It is majorly due to low sperm count, hormonal problem or presence of low number of motile sperms. Hence, fertility in male requires normal functioning of hypothalamus, pituitary gland, and testes. However, 40% -50% cases have no identifiable cause and 30% -40% cases are due to problem in the testes. The various causes of increasing infertility in male includes consumption of alcohol and drugs, rising stress level, obesity, smoking, and environmental toxins. Infertility in male diagnosed with various techniques such as DNA fragmentation techniques, oxidative stress analysis, sperm agglutination, sperm penetration assay, microscopic examination, and computer assisted sperm analysis.SpermCheck fertility is a U.S. FDA approved home screening test to determine low sperm count for men in 2012. According to the American Society for Reproductive medicines, in approximately 40% of infertile couples, male partner is sole cause of infertility and about 85% -90% are treated with conventional treatment such as drugs or surgery.

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Global male infertility treatment market segmented into drugs, hormonal therapy, and assisted reproductive technology (ART). Drugs used for male infertility treatment are clomiphene citrate,and tamoxifen.Hormonal therapy market further segmented into human chorionic gonadotropinhormone(hCG), and recombinant follicle stimulating hormone (rFSH).Gonadotropin therapy is given to the patients to increase the testosterone level and sperm count. If these therapies are not worked after 6 to 12 months treatment then option is assisted reproductive technologies. Assisted reproductive technology further is segmented intoin vitro fertilization-embryo transfer (IVF-ET), gamete intrafallopian transfer (GIFT), frozen embryo transfer (FET), and zygote intrafallopian transfer (ZIFT). Geographically, male infertility treatment market is segmented into North America, Europe, Asia Pacific, Latin America, Middle East and Africa, and rest of the World. Assisted reproductive technology segment dominated the global market due to higher success rate as compared to the drugs and hormonal therapy. However, doctors suggest ART treatment after the failure of drugs and hormonal treatment. In assisted reproductive technology segment in-vitro fertilization-embryo transfer is the most dominated procedure in 2014. Geographically, the North America is the highest revenue generating market due to more awareness, and reimbursement facility for male infertility treatment. However, Asia Pacific is expected to grow at a highest rate due to rising awareness, and increasing incidence of infertility in men due to changes in the lifestyle.

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Global male infertility treatment market is anticipated to grow at a faster rate due to the changes in the lifestyle, environmental effect, rising incidence of infertility cases, number of obese people, and increasing consumption of alcohol and drugs. According to the World Health Organization (WHO), globally 1.9 million obese and 600 million people were diagnosed to be overweight. Global organization for stress states that six out of ten people suffer from stress at work place and the highest stress rate was found at China (86%). However, the major limitation experienced in the male infertility treatment market is due to repeated treatment failures leading to an emotional impact on the patient. The person undergoing immense stress after the diagnosis or repeated failure of the treatment which would further result to intensify the infertility problem andresult in most of the patients to discontinue the treatment. The other limitation is the social taboo, and high cost associated with the treatment. Out of the 40% fertile men, only 15% of the men opt for the treatment for infertility due to the embarrassment, guilt, and other reasons.

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Some of the major players having presence in the global male infertility treatment market includesParallabs, European Sperm Bank, Origio, Cryolab Ltd., IrvineScientific, Microm UK Limited, and Merck Serono.

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Global Testosterone Replacement Therapy Market 2020: Business Growth Rate, Manufacturing Analysis, Size, Share, Cost Structure, and Forecast to 2026

The Market Data Analytics published a recent report on the globalTestosterone Replacement Therapy market, which was studied by the research analysts for months. The report includes information from trusted primary and secondary resources along with detailed examination from the research analysts. Based on the analysis, research analysts have concluded that the global demand for the global Testosterone Replacement Therapy market was USD XX Million in 2019 and is anticipated to reach USD XX Million by the end of 2026. The expected CAGR for the market is around XX%.

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Final Report will add the analysis of the impact of COVID-19 on this Industry.

The other factors that the report delivers is the revenue estimations, sales volume, industry size, and other important aspects, which includes market segmentation, growth factors, restraints, opportunities, challenges, and the market players.

The global Testosterone Replacement Therapy market incorporates information such as the basic overview of the industry, which includes definition, segmentation, and the industry structure. The global Testosterone Replacement Therapy market is segmented on the basis of{Gels, Injections, Patches, Other}; {Hospitals, Clinics, Others}. Along with this the product types and the applications of the Testosterone Replacement Therapy market are also discussed. Other data that is provided includes developmental trends, regional analysis of the Testosterone Replacement Therapy market, and the technological advancements. The developmental policies that have been updated are all discussed in the report.

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Some of the top most key players that are enlisted in the report areAbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals. The details that are represented in the report includes the cost structures, manufacturing process methodology, import and export consumption, supply and demand patterns, gross margins, recent developments made in the business, revenue analysis, and gross margins.

The report offers a comprehensive understanding of market dynamics across key regions, namely North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), Latin America (Brazil, Argentina), and the Middle East & Africa (Saudi Arabia, UAE, Egypt and South Africa).

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Key Questions Answered In The Report:

What is the growth potential of the global Testosterone Replacement Therapy market? Which regional market will emerge as a frontrunner during the forecast period 2020-2026? Which application segment will grow at a robust rate? What are the growth opportunities that may emerge in the industry in the years to come? What are the key challenges that the global market may face in the future? Which are the main companies in the global Testosterone Replacement Therapy market? Which are the growth strategies considered by the players to sustain hold in the global market?

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Testosterone boosters include medications and supplements designed to increase testosterone levels in the body. While low testosterone can trigger a range of symptoms, increasing this hormone comes with risks.

In this article, we discuss different types of testosterone boosters and their effectiveness.

Testosterone is an androgen hormone that promotes the development of characteristics people typically associate with masculinity, such as facial hair, deep voice, and muscle growth.

Although testosterone is the principal male sex hormone, it is also present in females, though at much lower levels.

Testosterone influences various aspects of the human body, including:

The normal testosterone value in people varies due to many factors, such as age. The American Urological Association defines low testosterone as less than 300 nanograms per deciliter (ng/dL).

A 2017 study suggests the normal total testosterone range for males aged 1939 years is 264916 ng/dL. The research considers values higher than this as abnormally high.

Low testosterone, or hypogonadism, can occur due to an underlying medical condition, taking certain medications, or injuries to the testes. People may also experience high testosterone levels, typically due to anabolic steroid use, tumors on the adrenal glands, or a medical condition.

A testosterone booster, or testosterone supplement, refers to any natural or artificially produced substance that raises testosterone levels. These may include:

TRT, or androgen replacement therapy, is a medical treatment for low testosterone. It works by replacing the testosterone that the body is not producing. TRT may include:

Injectable testosterone, such as testosterone cypionate (Depo-Testosterone) and testosterone undecanoate (Aveed), contain testosterone esters suspended in oil. Esters are a type of biological compound.

A person can administer this form of testosterone by injecting the solution into the buttocks. People can take these injections every 24 weeks, depending on recommendations from doctors.

Transdermal testosterone includes medicated patches (Androderm) and gels (AndroGel) that people apply directly to the skin.

Androderm patches come in four different strengths: 2 mg, 2.5 mg, 4 mg, or 5 mg of testosterone. The recommended starting dose is one 4 mg patch every 24 hours. A person should apply this to clean, dry skin on the back, thighs, abdomen, or upper arms.

Testosterone gel is available at 1% and 1.62% concentrations. When starting the 1% formulation, a person should apply 50 mg once a day in the morning. The dosage can vary depending on their hormone levels.

Jatenzo is an oral testosterone capsule recently approved by the Food and Drug Administration (FDA) for treating hypogonadism due to underlying medical conditions. The FDA does not recommend Jatenzo for treating age-related low testosterone due to an increased risk of cardiovascular events.

Jatenzo is available in three strengths: 158 mg, 198 mg, and 237 mg. The manufacturers recommend that people start by taking 237 mg twice daily for 1 week. In clinical trials, 87% of participants achieved testosterone levels in the normal range at the end of treatment.

After the first week, a doctor can adjust the dosage according to a persons serum testosterone levels. People should also note that due to a potential increase in blood pressure, Jatenzo may increase the risk of cardiovascular events.

Some supplements may help increase the level of testosterone a persons body produces. These may include:

D-aspartic acid (DAA) is an amino acid that plays a role in creating and releasing several different hormones, including testosterone.

DAA acts on the hypothalamus, triggering an increase of gonadotropin-releasing hormone (GnRH). When GnRH is present, the pituitary gland releases luteinizing hormone (LH), which promotes testosterone production.

Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands. It is a precursor hormone with minimal effects until the body converts it into other hormones, such as estrogen or testosterone.

Due to its effects, DHEA is a popular ingredient in testosterone-boosting supplements.

There are several reasons why a person might use testosterone boosters. These include:

Multiple factors can influence testosterone levels. The body naturally produces less of the hormone with age. In one 2016 study, researchers evaluated the levels of testosterone and DHEA of 271 healthy males between the ages of 4070.

The researchers found testosterone levels decreased by 1.28%, and DHEA decreased by 3.52% each year.

The following factors can lead to low testosterone levels:

TRT is effective in treating low testosterone, but it does not always address the underlying cause. A doctor may recommend lifestyle changes and other medication to treat hypogonadism due to overweight, metabolic disorders, or thyroid problems.

In a 2018 study, researchers coordinated seven controlled trials in 788 older males with low testosterone levels. The participants received either AndroGel 1% or a placebo for 12 months.

The results suggest that testosterone treatment led to moderate improvements in sexual function, bone density, and red blood cell count. Those in the testosterone treatment group showed mild improvements in walking distance, mood, and depressive symptoms.

In a 2017 article, researchers evaluated the efficacy of d-aspartic acid (DAA) reported in 27 animal and human studies.

Findings from the animal studies suggest that DAA increases testosterone levels. However, the human trials produced mixed results. This may be due to limitations of the study design, as well as differences in age, physical fitness levels, and the participants base testosterone levels.

A 2015 study researching the effects of DAA supplementation in 24 males with at least two years of resistance training suggests this technique either showed no significant changes or reduced testosterone levels based on the dosage.

The authors of a 2013 review examined findings from 25 randomized controlled trials that looked at the effects of DHEA supplementation in 1,353 men. The authors conclude it led to minor reductions in body fat, but no improvements in testosterone.

A 2018 review also states there is limited evidence to suggest that DHEA supplementation increases testosterone levels.

Testosterone boosters may provide the following benefits to people with low testosterone levels:

While testosterone replacement may help alleviate the symptoms of hypogonadism, it may not produce the same effects in people with naturally declining testosterone levels.

TRT may lead to the following side effects:

People who inject testosterone may experience pain, swelling, or bruising near the injection site. Topical testosterone gels and patches can also induce allergic reactions at the application site.

The American Urological Association only recommend TRT if a persons testosterone level is below 300 ng/dL, and they show symptoms of hypogonadism. However, the risks of TRT may outweigh its potential benefits.

The FDA does not regulate testosterone supplements, meaning that supplements vary widely in quality, purity, and dosage.

According to the FDA, there is a link between some bodybuilding supplements, as well as products marketed as testosterone alternatives, and the following adverse effects:

Testosterone boosters can help increase a persons testosterone levels. However, their effectiveness will vary based on the type of booster and a persons reasons for taking them.

Testosterone therapy appears to benefit people with conditions such as hypogonadism. However, TRT is usually not recommended to treat age-related declines in testosterone unless managing sexual dysfunction.

More research is necessary to support the use of alternative therapies, such as testosterone supplements. Supplements may also carry some risk of cardiovascular, kidney, and liver disease.

People should always consult a doctor before they start a new medication or supplement.

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Global Testosterone Replacement Therapy Market 2020: Business Growth Rate, Manufacturing Analysis, Size, Share, Cost Structure, and Forecast to 2026

The Market Data Analytics published a recent report on the globalTestosterone Replacement Therapy market, which was studied by the research analysts for months. The report includes information from trusted primary and secondary resources along with detailed examination from the research analysts. Based on the analysis, research analysts have concluded that the global demand for the global Testosterone Replacement Therapy market was USD XX Million in 2019 and is anticipated to reach USD XX Million by the end of 2026. The expected CAGR for the market is around XX%.

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Final Report will add the analysis of the impact of COVID-19 on this Industry.

The other factors that the report delivers is the revenue estimations, sales volume, industry size, and other important aspects, which includes market segmentation, growth factors, restraints, opportunities, challenges, and the market players.

The global Testosterone Replacement Therapy market incorporates information such as the basic overview of the industry, which includes definition, segmentation, and the industry structure. The global Testosterone Replacement Therapy market is segmented on the basis of{Gels, Injections, Patches, Other}; {Hospitals, Clinics, Others}. Along with this the product types and the applications of the Testosterone Replacement Therapy market are also discussed. Other data that is provided includes developmental trends, regional analysis of the Testosterone Replacement Therapy market, and the technological advancements. The developmental policies that have been updated are all discussed in the report.

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Some of the top most key players that are enlisted in the report areAbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals. The details that are represented in the report includes the cost structures, manufacturing process methodology, import and export consumption, supply and demand patterns, gross margins, recent developments made in the business, revenue analysis, and gross margins.

The report offers a comprehensive understanding of market dynamics across key regions, namely North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), Latin America (Brazil, Argentina), and the Middle East & Africa (Saudi Arabia, UAE, Egypt and South Africa).

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Key Questions Answered In The Report:

What is the growth potential of the global Testosterone Replacement Therapy market? Which regional market will emerge as a frontrunner during the forecast period 2020-2026? Which application segment will grow at a robust rate? What are the growth opportunities that may emerge in the industry in the years to come? What are the key challenges that the global market may face in the future? Which are the main companies in the global Testosterone Replacement Therapy market? Which are the growth strategies considered by the players to sustain hold in the global market?

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Global Testosterone Replacement Therapy Market 2020 Trends Analysis and Coronavirus (COVID-19) Effect Analysis | Key Players Market With COVID-19...

A campaign backed by a coalition of former competitors, sports scientists and doctors has called on World Athletics to reverse its decision to ban Caster Semenya and other female athletes with naturally high levels of testosterone from competing in certain events unless they take medication.

The #LetHerRun movement, conceived by the Africa agency, is aimed at pressuring the sport's worldwide governing body to change its rules regarding athletes with differences in sexual development (DSD).

Double Olympic 800 metres champion Semenya lost her appeal against the World Athletics ruling at the Swiss Supreme Court earlier this month.

The regulations force DSD athletes to take drugs to reduce their naturally-occurring testosterone if competing in women's events ranging from 400 metres to a mile.

DSD athletes with naturally high levels of testosterone need to medically limit that level to less than 5 nmol/L, double the normal female range of below 2 nmol/L.

The #LetHerRun movement, focused on Semenya and other athletes including Burundi's Francine Niyonsaba and Margaret Wambui of Kenya, "is aimed at pressuring the World Athletics in the face of the unequal treatment, calling for a counter-decision on the banning of athletes".

"Casters case deserves our attention because it affects the destiny of dozens of other athletes who will have their careers ended prematurely simply because they were born out of the standards imposed by technocrats from a regulatory agency," said Brazil's Jackie Silva, who won the inaugural Olympic beach volleyball gold medal with partner Sandra Pires at Atlanta 1996.

"Why hasnt the natural hormone production invalidated any male career ever?

"Has anyone stopped to compare Usain Bolts levels of testosterone to those of Justin Gatlin, for instance?"

Semenya, the 800m champion at the London 2012 and Rio 2016 Olympic Games, had previously appealed to the Court of Arbitration for Sport over the policy, but was unsuccessful.

The Swiss court ruling dealt a further blow to the 29-year-old, who will be unable to defend her Olympic crown at the postponed Tokyo 2020 unless she takes medication, as things stand.

World Athletics, known as the International Association of Athletic Federations (IAAF) when the controversial rules were introduced, insists that the regulations are in place to protect women's sport.

The South African Government has also offered its support to Semyena, with Minister of Sport, Arts and Culture Nathi Mthethwa vowing to "fight this injustice" of the current rules.

Original post:
Campaign group calls on World Athletics reverse testosterone rules - Insidethegames.biz

GlobalTestosterone Replacement Therapy MarketResearch Report is a resource, which provides current as well as upcoming technical and financial details of the industry to 2027. This report gives you so important and essentials data of Market size, share, trends, Growth, applications, forecast and cost analysis. Delivery development in North America, China, Europe, and South East Asia, Japan as well as in the Globe. The report proves to be indispensable when it comes to market definition, classifications, applications and engagements.

The market report also computes the market size and revenue generated from the sales. The industry analysis report presents the key statistics on the market status of global and regional manufacturers and also acts as a valuable source of leadership and direction. What is more, the Testosterone Replacement Therapy market report analyses and provides historic data along with the current performance of the market.

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Global Testosterone Replacement Therapy Market competition by Top Key Players: AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc.

Testosterone Replacement Therapy Market section by Region:

Segmentation: The report has been separated into different categories, such as product type, application, end user, and region. Every segment is evaluated based on the CAGR, share and growth potential. In the regional analysis, the report highlights the prospective region, which should generate opportunities in the global Testosterone Replacement Therapy market in the years to come. This segmented analysis will surely prove to be a useful tool for readers, stakeholders and market participants to get a full picture of the Testosterone Replacement Therapy global market and its growth potential in the years to come.

The Testosterone Replacement Therapy Market report offers a plethora of insights which include:

Changing consumption patterns among individuals globally.

Historical and future progress of the global Testosterone Replacement Therapy market.

Region-wise and country-wise segmentation of the Testosterone Replacement Therapy market to understand the revenue, and growth lookout in these areas.

Accurate Year-on-Year growth of the global Testosterone Replacement Therapy market.

Important trends, including proprietary technologies, ecological conservation, and globalization affecting the global Testosterone Replacement Therapy market.

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Important Information that can be extracted from the Report:

Assessment of the COVID-19 impact on the growth of the Testosterone Replacement Therapy Market

Successful market entry strategies formulated by emerging market players

Pricing and marketing strategies adopted by established market players

Country-wise assessment of the Testosterone Replacement Therapy Market in key regions

Year-on-Year growth of each market segment over the forecast period 2026

The Testosterone Replacement Therapy Market report considers the following years to predict market growth:

Historic Year: 2014 2018

Base Year: 2019

Estimated Year: 2020

Forecast Year: 2020 2027

The Global Testosterone Replacement Therapy Market is displayed in 13 Chapters:

Chapter 1: Market Overview, Drivers, Restraints and Opportunities

Chapter 2: Market Competition by Manufacturers

Chapter 3: Production by Regions

Chapter 4: Consumption by Regions

Chapter 5: Production, By Types, Revenue and Market share by Types

Chapter 6: Consumption, By Applications, Market share (%) and Growth Rate by Applications

Chapter 7: Complete profiling and analysis of Manufacturers

Chapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expenses

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Market Effect Factors Analysis

Chapter 12: Market Forecast

Chapter 13: Testosterone Replacement Therapy Research Findings and Conclusion, Appendix, methodology and data source

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Testosterone Replacement Therapy Market Growth Analysis with Top Players Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International...

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