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The following is a summary of Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression, published in the November 2023 issue of Endocrinology by Albrethsen, et al.

While insulin-like factor 3 (INSL3) is recognized as a Leydig cell biomarker, its response to hypothalamus-pituitary-testicular suppression remains less understood. For a study, researchers sought to investigate the concurrent alterations in serum concentrations of INSL3, testosterone, and LH during experimental and therapeutic testicular suppression.

Serum samples from three cohorts undergoing testicular suppression were analyzed: healthy young men treated with androgens (Sustanon); transgender girls (male sex assigned at birth) receiving 3-monthly GnRH agonist injections; and patients with prostate cancer subjected to surgical castration or GnRH agonist treatment. Serum INSL3 and testosterone were quantified using liquid chromatography-tandem mass spectrometry, and LH was measured through an ultrasensitive immunoassay.

Experimental testicular suppression in healthy men using Sustanon led to decreased circulating concentrations of INSL3, testosterone, and LH, which subsequently returned to baseline after suppression release. Similarly, transgender girls and prostate cancer patients undergoing therapeutic hormonal hypothalamus-pituitary-testicular suppression exhibited reduced levels of all three hormones.

INSL3 demonstrated sensitivity as a testicular suppression marker, mirroring testosterones behavior and indicating Leydig cell function. INSL3 measurements in serum could complement testosterone as a marker in male reproductive disorders, therapeutic testicular suppression, and monitoring the illicit use of androgens.

Source: academic.oup.com/jcem/article-abstract/108/11/2834/7180820?redirectedFrom=fulltext

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Analysis of LH, Testosterone, and Serum INSL3 in Experimental and Therapeutic Testicular Suppression - Physician's Weekly

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Hannah Frye is the Assistant Beauty Editor at mindbodygreen. She has a B.S. in journalism and a minor in womens, gender, and queer studies from California Polytechnic State University, San Luis Obispo. Hannah has written across lifestyle sections including health, wellness, sustainability, personal development, and more.

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An estimated 25% of adults in the U.S. struggle with arthritis, making it a rampant (and often under-discussed) issue.The most common cause of arthritis is general wear and tearhowever, researchers have found another unexpected link that may be helpful for those struggling.Here's what to know:

For this study, researchers looked at 2013 to 2016 data from an ongoing U.S. database called The National Health and Nutrition Examination Survey2 , or NHANES for short. This study included a total of 10,439 people, mainly aged 20 years and older, 48% of whom were men.

The association between arthritis and low testosterone held up for both men and women. This makes the case that testosterone level testing may be helpful for anyone struggling to understand the root of their arthritis, no matter their gender.

This study found other correlations, too, such as smoking, waist circumference, BMI, high blood pressure, diabetes, and cardiovascular diseaseso testosterone is certainly not the only thing to consider.However, it's an important one, especially for perimenopausal and postmenopausal women who tend to have low testosterone levels3 due to declining adrenal function.

Knowing this association exists may inspire those who are struggling with arthritis to get a hormone test if possible. From there, your health care provider can give you personalized advice and treatment for both hormonal health and joint comfort.

Though testosterone is best known as a male sex hormone, this research reminds us that it's important for women's health, too.

You may also look to DHEA supplements. "The body synthesizes DHEA before converting it to testosterone, making it a reasonable choice for supplementation," Vinjamoori says. However, it's best to consult your health care provider before starting this supplement to ensure it's a necessary part of your routine.

And rememberthis finding is solely an association, not a statement of cause. So, more research is needed to determine if low testosterone causes arthritis or if the correlation is related in another way.

A new analysis study found that patients with arthritis had significantly lower testosterone levels than those without arthritis. This could be a sign that testosterone may play a role in arthritis onset or progression, but more research is needed to be sure. In the meantime, men and women can support their testosterone levels through lifestyle changes and consult a physician if they're interested in hormone testing.

Link:
Low Testosterone Associated With Arthritis In Men & Women | mindbodygreen - mindbodygreen

A recent study conducted in the Netherlands on women suffering from social anxiety disorder revealed that participants with stronger avoidance tendencies experienced larger reductions in fear during a therapy session after receiving testosterone, compared to when they received a placebo. However, this effect did not persist into subsequent sessions, nor did it impact the severity of their symptoms. The study was published in Psychoneuroendocrinology.

Social anxiety disorder is a mental health condition characterized by an intense and persistent fear of social situations. Individuals with this disorder often experience overwhelming anxiety and self-consciousness in social interactions, leading to a strong desire to avoid social events (i.e., to social avoidance). Physical symptoms such as trembling, sweating, and a rapid heartbeat may accompany these feelings of distress. Social anxiety can significantly impact a persons daily life, hindering their ability to form relationships, attend social gatherings, or perform in public.

The standard treatment for the disorder includes therapy and psychiatric medications, but scientists are constantly looking for new treatment options as well. One potentially promising substance for this purpose is testosterone, the male sex hormone. Previous studies indicated that its administration can stimulate approach behaviors in healthy individuals, but also in highly avoidant individuals with social anxiety disorder.

Study author Moniek H.M. Hutschemaekers and her colleagues aimed to investigate whether administering testosterone to women with social anxiety disorder during exposure therapy would effectively reduce their social avoidance tendencies. The hypothesis was that testosterone would be most effective in women with the highest avoidance tendencies. To explore this, the researchers conducted an experiment.

The study included 55 female participants suffering from social anxiety disorder, aged between 18 and 43 years. They were recruited from an outpatient clinic specializing in anxiety disorders at Radboud University Nijmegen, the Netherlands, and from the community.

The researchers randomly assigned participants to receive either testosterone or a placebo treatment. The testosterone treatment involved a solution containing 0.5 ml of testosterone and other substances. The placebo solution contained the same substances, excluding testosterone. Four hours before the first exposure therapy session, participants held their assigned solution under their tongue for 60 seconds. Neither the participants nor the researchers administering the treatment knew which solution each participant received.

Participants underwent two public speaking exposure sessions, each lasting 90 minutes. These sessions are termed exposure sessions as they confront participants with an activity they fear in this case, public speaking. The first session occurred after the administration of either the placebo or testosterone treatments, while the second session was scheduled a week later.

Participants completed assessments of social anxiety symptom severity (using the Social Phobia Scale), fear levels (using the Subjective Unit of Distress Scale), and approach-avoidance tendencies (using the Approach Avoidance Task) at multiple time points before and after the exposure sessions. They also provided saliva samples at eight different times throughout the study to enable the authors to monitor their testosterone levels.

The results indicated that those assigned to the testosterone treatment, particularly participants with higher avoidance tendencies, showed a greater reduction in fear immediately after taking testosterone compared to those with lesser avoidance tendencies. This effect was not observed in the placebo group.

However, analysis of the results from the second session did not reveal a correlation between avoidance and fear reduction in the testosterone group. Intriguingly, after considering baseline testosterone scores, stronger avoidance scores were linked to lower overall fear levels in this group. The study authors found no effect of testosterone on social anxiety symptoms or the relationship between these symptoms and avoidance tendencies.

The current study adds to a growing body of literature indicating that individuals with SAD [social anxiety disorder] who enter exposure treatment with strong social avoidance tendencies may benefit from additional treatment with testosterone, the study authors concluded.

The study sheds light on the effects of testosterone administration on women with social anxiety disorder. However, the study sample was very small. Due to this, researchers were not able to detect small effects.

The paper, Social Avoidance and Testosterone Enhanced Exposure Efficacy in Women with Social Anxiety disorder: A Pilot Investigation, was authored by Moniek H.M. Hutschemaekers, Rianne A. de Kleine, Mirjam Kampman, Jasper A.J. Smits, and Karin Roelofs.

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Testosterone might temporarily help reduce avoidance tendencies in women with social anxiety disorder - PsyPost

As men age, they undergo a natural process known as andropause, akin to the female experience of menopause. This transformation signifies a gradual decline in testosterone production, a hormone critical to male well-being. It's an inevitable process, with testosterone levels diminishing by roughly one per cent each year after the age of 30, says Dr. Martin Galy, Body Identical Hormone Lead Physician at 23MD, a specialised cosmetic and medical clinic. However, the impact varies among individuals, depending on their initial testosterone levels.

For some men who start life with naturally high testosterone levels, this decline may not significantly affect them. Their bodies maintain sufficient testosterone to support essential functions. In contrast, approximately 20 to 30 per cent of men who began adulthood with mid-range or lower testosterone levels might face challenges in their midlife, typically in their early to mid-40s, he adds.

Related:New approach to detect colorectal cancer in the UAE

As testosterone levels drop, they can experience symptoms related to andropause, often mirroring menopausal symptoms in women, including mood swings, depression, irritability, weight gain, hot flashes, reduced libido, and erectile problems.

The consequences of untreated andropause can be severe, potentially leading to long-term health issues such as diabetes, cardiovascular disease, and cognitive decline. However, awareness of andropause remains limited, as it has not received the same attention as menopause in women. This knowledge gap presents a significant challenge in healthcare, as many men suffering from andropause may not recognise the root cause of their symptoms. They might be misdiagnosed and prescribed treatments for unrelated conditions like depression or erectile dysfunction, leaving the underlying hormonal issue unaddressed.

To address these challenges, it is crucial to raise awareness about andropause and its symptoms among middle-aged men, encouraging open discussions.

In terms of solutions, pharmaceutical companies and healthcare providers offer safe and effective treatments for andropause. Hormone replacement therapy (HRT), often administered through gels or creams applied to the skin, can help restore testosterone levels to a more balanced state, replicating the body's natural hormone production rhythm, explains Galy. This medical intervention not only alleviates symptoms but also reduces the risk of long-term health complications.

Dr. Martin Galy

Testosterone can be administered in two primary forms, each with its unique benefits and considerations. The first method involves the application of testosterone in the form of creams or gels that are absorbed through the skin. This approach is widely regarded as a safer alternative, thanks to its ability to mimic the body's natural testosterone production. The key distinction lies in its ability to provide a natural peak in testosterone levels twice daily, aligning with the body's circadian rhythm.

Related:World Heart Day: Innovations in electrophysiology and LVAD technology

In contrast, the second method entails the use of injectable forms of testosterone. While injectables are effective in elevating testosterone levels, they do so without the natural peaks and troughs experienced with transdermal application. This constant elevation of testosterone may present some associated risks. Notably, high testosterone levels can stimulate the bone marrow to produce excessive red blood cells, leading to thickened blood. Thickened blood can pose risks of clotting, potentially resulting in blood clots and even heart attacks.

In light of these considerations, a cautious approach is recommended. For middle-aged men seeking HRT with testosterone, experts often advise starting with transdermal methods before considering injectable forms. This step can help mitigate potential risks while striving for optimal hormone balance.

In essence, HRT serves as a vital tool in restoring and maintaining hormone balance for both men and women. It has the potential to alleviate symptoms, enhance well-being, and improve overall health. By embracing the right approach, guided by medical expertise, individuals can embark on a journey towards a healthier, more balanced life through HRT.

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Understanding the impact of andropause on men's health - Omnia Health Insights

New research has uncovered a significant relationship between the level of neighborhood disorder a pregnant woman experiences and increased levels of testosterone during pregnancy. This finding, published in BMC Pregnancy and Childbirth, opens new avenues in understanding how our environment can directly influence prenatal development.

The genesis of this research lies in a body of evidence suggesting that where we live can significantly affect our health. Prior studies have shown that characteristics of neighborhoods, such as the prevalence of crime or the condition of buildings, can influence a range of health issues from heart disease to mental health disorders.

These findings led researchers to wonder about the specific impact of neighborhood environments on pregnant women and their unborn children. Notably, earlier studies have linked neighborhood characteristics to pregnancy outcomes, like preterm births, but how these environments affect pregnancy at a physiological level remained less understood.

Our lab focuses on environmental and psychosocial exposures that impact maternal and child health particularly during pregnancy, said study author Zorimar Rivera-Nez, an assistant professor at Rutgers School of Public health and a resident faculty at Rutgers Environmental and Occupational Health Sciences Institute (EOHSI).

Pregnancy is a very critical time for child health, and adverse exposures during this time can impact health later in life including in childhood, adolescence and adulthood. In this case, we studied alterations in sex-steroid hormones during pregnancy as a possible pathway or mechanism for psychosocial stressors to impact the babys health.

These hormones are essential to maintain pregnancy and to sustain baby growth. Evidence suggest that neighborhoods characteristics impact pregnancy outcomes such as preterm birth and low birthweight, here we explore as sex steroid hormones as a potential pathway for those adverse outcomes.

To explore this, researchers conducted a study involving 262 pregnant women who were in the first trimester of their pregnancies. These women were recruited from outpatient obstetric clinics associated with Rochester University Medical Center between December 2015 and April 2019.

To ensure a focused study group, the researchers set specific criteria for participation: the women had to be at least 18 years old, carrying a single baby, free from major substance abuse or psychotic illnesses, and able to communicate in English. Those with major endocrine disorders, high-risk pregnancies, or significant obstetric problems were excluded from the study.

Once enrolled, these women embarked on a journey through their pregnancies with the research team, attending face-to-face visits during each trimester. The researchers were particularly interested in two aspects: the womens neighborhood environment and their hormone levels.

To gauge the level of stress in their neighborhoods, a City Stress Inventory questionnaire was administered in the third trimester. This tool is a well-established method to measure neighborhood stress, comprising 18 questions about various aspects of neighborhood life, including the presence of vacant buildings and personal experiences of violence. The answers to these questions were then used to develop a comprehensive picture of the level of disorder and violence in each womans neighborhood.

Alongside this, the researchers were tracking changes in the womens hormones. Blood samples collected each trimester were analyzed for five key hormones: estrone, estradiol, estriol, total testosterone, and free testosterone. These hormones were chosen because of their crucial role in pregnancy and fetal development. The technique used for this analysis was liquid chromatography with tandem mass spectrometry, a highly accurate method for hormone measurement.

The researchers found that as the level of neighborhood disorder increased, so did the concentrations of testosterone in the womens blood across their pregnancies. This was particularly true for women carrying male babies. In contrast, no significant relationship was observed between neighborhood disorder and the four other hormones measured.

It is interesting that we observed alterations in androgen levels, which have been associated with stress in animal studies, Rivera-Nez told PsyPost. This is similar to what we observe with other stressors that alter endocrine pathways.

The relationship between neighborhood conditions and hormone levels was most pronounced in the third trimester of pregnancy. The researchers found that the higher the level of neighborhood disorder, the greater the increase in testosterone during this critical period of fetal development.

Overall, the findings highlight that where you live impact your health, in this case pregnancy health, Rivera-Nez said.

While the study found a correlation between neighborhood disorder and increased testosterone levels during pregnancy, its crucial to understand that correlation does not imply causation. The exact mechanisms behind this association remain unclear, and further research is necessary to unravel these complex interactions.

Study participants come for Rochester and we may not be able to generalize these findings to the United States as a whole, Rivera-Nez noted. Also, while we know stress impact pregnancy outcomes the pathways for this impact are still unknown. Our study is one of the first ones trying to determine the possible pathways, as such similar studies are needed in other populations.

I would like to reiterate that maternal stress and neighborhood characteristics have an impact on population health and this impact may have long-term consequences, particularly for exposures that occur while baby is in utero, she added.

The study, Associations between neighborhood stress and maternal sex steroid hormones in pregnancy, was authored by Megan C. Hansel, Hannah R. Murphy, Jessica Brunner, Christina Wang, Richard K. Miller, Thomas G. OConnor, Emily S. Barrett, and Zorimar Rivera-Nez.

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Neighborhood disorder linked to increased pregnancy testosterone levels - PsyPost

CALGARY, AB, Dec. 5, 2023 /CNW/ - Calgary welcomes a ground-breaking addition to its healthcare landscape with the opening of Rufus Health, the first dedicated Testosterone Clinic in Alberta focused on enhancing men's health and well-being. The clinic, located at 124, 2210 2nd Street S.W. in the former Holy Cross Hospital in Mission, officially opened its doors on November 15, 2023.

Calgary, renowned for its vibrant community and commitment to health, is now home to a specialized facility designed to address the unique needs of men seeking to optimize their testosterone and overall wellness. Testosterone levels begin to decline when men reach their late 30's and early 40's, and 40% of men in Canada over the age of 45 suffer from testosterone deficiency. Lifestyle and environmental factors including stress, poor diet, a lack of physical activity and lack of sleep can negatively affecttestosterone levels even further, and if left untreated may decrease life expectancy.

Key Services and Features of Rufus Health:

Rufus Health is led by Founder, Roger Balm who was wintering in the United States and was tested with low testosterone, and described his first TRT experience as, "it felt like someone plugged me into a wall like a phone charger, and right away my mood was upbeat, I felt more alert, and my energy was better." After returning to Calgary Roger thought it would be relatively simple to resume his TRT treatment, however it ended up being far more challenging, which was the impetus to starting Rufus Health.

Medical Director, Julie Bakko, said "checking testosterone levels is as easy as having a simple blood test examining a number of key bio markers, however the results are merely numbers without a full assessment, and whether it's to relieve symptoms, improve quality of life or simply getting back to feeling good, we are excited to provide personalized, evidence-based care that enhances the vitality of our clients."

Low testosterone is rarely talked about and as a result under diagnosed. Men often brush off adverse symptoms such as low energy, fatigue, mood changes, reduced libido, decreased muscle strength, etc. as part of "growing older" or the consequences of a busy life. But according to Bakko, "no matter how "young" you are, or how hectic your life is, you shouldn't feel weak, tired, irritable, or exhausted every day."

About Rufus Health:Rufus Health is the first dedicated testosterone replacement therapy clinic of its kind in Alberta. Dedicated to providing personalized and comprehensive care to enhance men's health and vitality. With a commitment to excellence and a focus on the latest medical advancements, the clinic aims to empower individuals to achieve optimal well-being.

https://www.rufushealth.com

SOURCE Rufus Health Corp.

For further information: Tracy Logan, Chief Marketing Officer, [emailprotected]

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New Testosterone Clinic Opens its Doors in Calgary, Empowering Men's Health and Vitality - Canada NewsWire

Boulder, Colorado, where I was born and raised, is sometimes called the fittest city in America. Septuagenarians go skiing before work, high-school delinquents hang out at the climbing gym, and people do not so much hike as trail run. Every year, the town hosts the BOLDERBoulder, one of the largest road races in the country and a sort of festival day in honor of the local god of exercise. I first ran the ten-kilometre course when I was six, not an unusual age of initiation for locals, and discovered that I was a bizarrely good runner. Three years in a row, I finished first out of some four hundred girls my age, and fifth or sixth out of a similar number of boys. At twelve, the last year I raced, I ran what was then the sixth-fastest time ever recorded by a twelve-year-old girl in the races three decades of results. My parents were baffled. This was no gene of theirs, surely, but it also didnt seem to be hard work. I didnt care about running, and I never trained.

What I did work at, harder than I have worked at anything since, was soccer. Colorados Front Range produces many excellent soccer playersall of the United States goals in last summers Womens World Cup were scored by players who grew up within an hours drive of Boulderand the great disappointment of my cushy childhood was realizing that I was not to be one of them. I failed, year after year, to make the local clubs first team. I made my high schools varsity team as a sophomore but didnt start a game until I was a senior. If you had asked me at fifteen if I would rather be a little better at soccer or one day find true love, I wouldnt have paused to think. I didnt dream at night of love but of wide green spaces, well-timed tackles, and chipped shots.

The other dream of my youth, which I did not then see as bearing any relation to athleticism, was to be rid of my acne. From puberty on, it wavered between demoralizing and disfiguring. At the end of college, I finally got on Accutane, which left me with a toxified liver andfor two glorious yearsthe skin of a baby. Then the acne came back, worse than ever. It looked like I had picked a fight with a wasps nest and lost. In the fall of 2022, I moved to Mexico City and saw a dermatologist there. I wanted another round of Accutane, liver be damned. She agreed, all but wincing, that the situation was dire, but insisted that hormonal causes like polycystic ovary syndrome, or P.C.O.S., first be ruled out. This was annoying: the blood tests were expensive, and several American dermatologists had explained to me that hormonal acne fluctuates over the menstrual cycle, whereas mine stayed bad all month long. But I was desperate, and I did as she said.

A week later, the blood tests came back. In a one-room office in downtown Mexico City, a grandmotherly gynecologist who called me hija and my breasts mamas explained that I had a condition called hyperandrogenism: an excess of the sex hormones associated with men, including testosterone, and very likely the cause of the past decade of acne. My estrogen levels were considerably lower than those of most premenopausal women; they were typical of prepubescent children of either sex. My free-testosterone levelsone of three forms of the hormonewere well above the usual female range. In most women my age, the concentration of androstenedione, a precursor to testosterone, is between thirty and two hundred and eighty-five nanograms per decilitre. Mine was six hundred and twenty. It was all the weirder, the doctor said, because for years I had been on hormonal birth control, which tends to suppress androgen levels.

I received all of this in rapid medical Spanish. There was a processing lag, and then shock and something like fear. I remember nodding a lot, and wanting to cry. But I had never identified as anything other than a girl or a woman, and, after five minutes dazed reflection, I saw no reason why a blood test should change that. And what a relief to know that my acne stemmed not from, say, sins committed in a previous life but from something as blameless and adjustable as hormones. The kindly doctor suggested three medicines: a dietary supplement, a new birth control containing drospirenone, and a pill called spironolactone. This last, I happened to know, is prescribed to trans women in the U.S. as a component of hormone-replacement therapy. I would learn that it can also be used alongside birth control by intersex women who must lower their total testosterone levels in order to compete in certain lite sports.

Like many other longtime followers of womens sports, I had in the past few years watched the debate over the sex line growsurreallyfrom a debate among fans of womens track to a national wedge issue. If you take out a loan, you pay it back, Tim Scott said this year during the first Republican primary debate. If you commit a violent crime, you go to jail. And, if God made you a man, you play sports against men. This summer, Nikki Haley called biological boys playing in girls sports the womens issue of our time.

Before my blood tests, on the rare occasions when I considered my stance on the issue, I had viewed myself as a member of the putative victim groupsports-playing cis women who really like to wineven as I was not particularly afraid that increased gender diversity would destroy womens sports as we know them. (Anyone who thinks that legions of men will declare themselves women only to compete in an easier division is, I think, missing something crucial about the nature of masculine pride.) After the blood tests, I was still sports-playing, still cisgender, and still tediously competitive. But now, in a sporting world that increasingly divided the sexes based on hormone levels, I was less sure about who was the threatened and who was the threat.

The rationale for separating men and women in lite sports is well established. Across many sports with quantitatively measurable results, the best men perform between nine and twelve per cent better than the best women. In sports that rely on explosive strength, the sex gap is even bigger: a fifteen-year-old boy has jumped farther than any woman on record. Male athletic superiority is not absolutewomen are better at very long-distance swimming, for example, and a Brazilian woman named Maya Gabeira surfed a bigger wave than anyone else in the 2019-20 season. Nor does it hold true across time: improvements in nutrition, equipment, recruitment, and training have led the best women today to run as fast as the best men did a hundred years ago. But, among contemporaneous athletes, the pattern of dominance is uncontroversial. The United States Womens National Soccer Team, to my abiding shame, once lost, 25, in a scrimmage against teen-age boys on an F.C. Dallas developmental team.

The hard question for sports administrators, then, is not whether to have a sex line in lite sports but how, exactly, to distinguish between brawny but nevertheless legitimate women and dishonest male infiltrators. This proved, as early as the nineteen-thirties, to be difficult. Joanna Harper recounts in Sporting Gender, a lively history of intersex and trans athletes, that the best runners in the womens division at the time tended to be bulky and sharp-jawed; they had gravelly voices and, as an added strike, often were not married. Helen Stephens, Stella Walsh, and Kthe Krauss, respectively the gold, silver, and bronze medallists in the hundred-metre sprint at the 1936 Berlin Olympics, all faced suspicion around their sex. The fourth-place finisher, a German teammate of Krausss, complained that she was the only woman in the race.

At the time, it was not unheard of for a top American athlete to allay suspicions about her sex by adopting more feminine dress or entering into a marriage of convenience. (Sex and sexuality were often conflated.) Stephens, who would later have a forty-year partnership with a woman, defended herself by suggesting that she was attractive to men: she liked to tell a story about the Olympic host, Adolf Hitler, grabbing her ass. Helen is absolutely a girl, Stephenss mother told reporters, adding that she attends dances regularly at college. On the other hand, Walsh, who was also a lesbian, did not keep up with such feminine niceties as shaving her legs. I am not beset by the temperamental tempests which women are supposed to have, she reportedly said.

Decades later, Walsh, who spent the rest of her career coaching kids in Cleveland, would be killed in a parking-lot robbery. The autopsy results, which were leaked, revealed that she had atypical genitalia: a hole in the perineum for urination, but also small testes. Further testing showed that she had what is called a mosaicism of chromosomes: in her case, some cells with a single X chromosome and others with XY. Walshs ex-husband, whom she had married in order to switch her running eligibility from Poland to the United Statesthey divorced after three monthslater told journalists that theyd had sex infrequently, and only with the lights off. A close friend described Walsh as a self-conscious woman who lived a tragic life.

Continued here:
Who Gets to Play in Women's Leagues? - The New Yorker

in: Health, Health & Fitness, Podcast

Brett & Kate McKay May 8, 2023

When men think about optimizing their hormones, they tend only to think about raising their testosterone. But while increasing T can be important, an ideal health profile also means having testosterone thats in balance with your other hormones as well.

Today on the show, Dr. Kyle Gillett joins me to discuss both of those prongs of all-around hormone optimization. We start with a quick overview of the different hormones that affect male health. We then get into what qualifies as low testosterone and how to accurately test yours. We also discuss what causes low testosterone in individual men, and how its decline in the general male population may be linked to both birth control and the world wars. In the second half of our conversation, we discuss how to both raise testosterone and get rid of excess estrogen, including the use of some effective supplements you may never have heard of. We then get into the risks and benefits of taking TRT, before ending our discussion with what young men can do to prepare for a lifetime of optimal T and hormonal health.

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Podcast #893: Optimize Your Testosterone - Art of Manliness

Charlotte, NC - (NewMediaWire) - May 10, 2023 - Hormonal imbalances in men can result in several unpleasant symptoms that can significantly affect their quality of life. These symptoms include decreased libido, fatigue, depression, weight gain, and muscle loss, among others. Fortunately, testosterone replacement therapy can help alleviate these symptoms and improve overall wellness.

QC Kinetix (Charlotte) offers testosterone replacement therapy as a natural and effective way to address hormonal imbalances in men. Their board-certified physicians specialize in diagnosing and treating hormone deficiencies, ensuring that each patient receives a personalized treatment plan tailored to their specific needs. The clinic's advanced technology and equipment ensure patients receive the best possible care and treatment outcomes.

"Don't let your lack of intimacy, energy, and restful sleep limit your potential. At QC Kinetix (Charlotte), we help our patients restore their hormone balance so they can experience the vitality of life again," said the clinic's spokesperson.

Muscle mass and bone density are crucial in men active in sports and other physical activities. Unfortunately, the content of these two essential body components is influenced by testosterone, which diminishes over time. This can result in an increased risk of injury from everyday activities. QC Kinetix (Charlotte) recognizes this natural decline of testosterone and has incorporated testosterone replacement therapy in its treatments to help men remain active. By helping men maintain a healthy balance of hormones, the Charlotte testosterone replacement therapy clinic has been instrumental in helping them achieve optimal fitness and wellness.

A sedentary lifestyle has long been known as a leading cause of weight gain. However, it's worth noting that decreased testosterone levels can also play a significant role in this condition. Fortunately, QC Kinetix (Charlotte) is committed to helping men achieve their weight loss goals by providing comprehensive guidance and support through testosterone replacement therapy. This innovative treatment approach has been shown to improve self-esteem and overall well-being, helping men feel more confident and energized as they work towards their weight loss goals.

Sleep difficulties can be caused by a variety of factors, including hormonal imbalances. Men who suffer from an imbalance in testosterone levels may experience a significant impact on their quality of sleep. QC Kinetix (Charlotte) recognizes the importance of restful and restorative sleep in maintaining good health and well-being. That's why they offer a range of restorative therapies designed to help their patients achieve more restful and restorative sleep. Patients who have undergone these treatments have reported significant improvements in their quality of life, including better sleep and improved energy levels.

QC Kinetix (Charlotte) also offers a range of restorative therapies that target joint pain. Their board-certified physicians have extensive experience diagnosing and treating joint pain conditions, including those affecting the knee, hip, ankle, shoulder, elbow, and wrist. Whether patients are experiencing acute or chronic joint pain, the clinic provides customized treatment plans to alleviate their symptoms and improve their mobility.

The clinic's regenerative medicine therapies also aim to help athletes and active individuals recover from injuries sustained during workouts, in the field, or due to overuse. These natural treatments can be an alternative to knee and hip replacement surgeries and can help with a range of injuries, including sprains, strains, back injuries, and torn ACL/MCL.

Through QC Kinetix's natural treatments, patients can regain mobility and enjoy activities that they once performed with ease. For example, patients who once struggled to walk or run due to joint pain can now engage in these activities without discomfort. Similarly, patients who had to give up their favorite sport or hobby due to muscle pain or injury can resume their activities after receiving the clinic's restorative therapies.

To make patients feel at ease and relaxed during their treatments, QC Kinetix (Charlotte) offers concierge services, such as refreshments and comfortable seating. Additionally, they provide logistical support to ensure that patients can focus on their recovery without worrying about scheduling or transportation issues.

QC Kinetix (Charlotte) is located at 309 S Sharon Amity Rd Suite 302, Charlotte, NC, 28211, US. Contact the testosterone replacement therapy clinic at (704) 360-3057 or visit their website to learn more about their services.

Media Contact:

Company Name: QC Kinetix (Charlotte)

Contact Person: Marc Difronzo

Phone: (704) 360-3057

Address: 309 S Sharon Amity Rd Suite 302

City: Charlotte

State: NC

Postal Code: 28211

Country: US

Website: https://qckinetix.com/charlotte/sharon-amity/

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Experience a Renewed Sense of Vitality with QC Kinetix (Charlotte) Testosterone Replacement Therapy - Yahoo Finance

The following is the summary of Decreased Testosterone Levels Precede a Myocardial Infarction in Both Men and Women, published in the January 2023 issue of Cardiovascular Disease by Faresj et al.

This study compares a large random sample of the general population with middle-aged men and women to examine the possible impact of the hormone testosterone on the risk of myocardial infarction. Testosterone levels in hair were evaluated using radioimmunoassay 1 month and 3 months before an ST-elevation or non-ST-elevation acute myocardial infarction. In addition, middle-aged men and women (n=168) with a history of myocardial infarction had their mean testosterone levels evaluated (the acute myocardial infarction [AMI] cases).

The (n=3,150) people were measured once to serve as controls; they were all roughly the same age. No significant difference in hair testosterone levels between AMI patients and controls was identified 3 months before AMI in either sex. However, testosterone levels were dropping (P<0.001) in both men and women in the month leading up to AMI, with a drop from 2.84 to 2.10 pg/mg in men and from 1.43 to 1.10 pg/mg in women. Although traditional cardiovascular risk factors were investigated as potential confounders, they did not affect this trend.

Additionally, a second control group (n=205) from the general population was used to compare the AMI cases. A trend of declining testosterone levels was noticeable for men exclusively, even in the tiny control group. There may be some natural, physiologic change in testosterone levels over time, and this control group was tiny. The results of this study suggest that low testosterone levels play a role in the pathophysiological processes leading up to myocardial infarction, suggesting that this association deserves further study.

Source: sciencedirect.com/science/article/pii/S0002914922010682

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