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High levels of the sex hormone testosterone may trigger different health problems in men and women, a new study reveals.

In women, testosterone may increase the risk for type 2 diabetes, while in men it lowers that risk. But high levels of testosterone increase the risk for breast and endometrial cancer in women and prostate cancer in men, the researchers reported.

"Our findings provide unique insights into the disease impacts of testosterone. In particular, they emphasize the importance of considering men and women separately in studies, as we saw opposite effects for testosterone on diabetes," said lead researcher Katherine Ruth, of the University of Exeter in the United Kingdom.

"Caution is needed in using our results to justify use of testosterone supplements until we can do similar studies of testosterone with other diseases, especially cardiovascular disease," Ruth explained in a University of Cambridge news release.

Dr Joel Zonszein, an emeritus professor of medicine at Albert Einstein College of Medicine in New York City, said there is a "sweet spot" of normal values for men and women. "Too much is not good, and too little is also bad," he explained.

"Testosterone supplementation is widely used in both men and women with normal values with no good evidence of benefit. Testosterone replacement in truly deficient individuals is something else," said Zonszein, who had no role in the study.

For the study, British researchers collected genetic data on more than 425 000 men and women listed in the UK Biobank. The investigators found more than 2 500 genetic variations associated with levels of testosterone and the protein that binds it sex hormone-binding globulin.

The researchers checked their results with analyses of other relevant studies and used a randomisation method to see if associations between testosterone and disease are causal.

In women, a high level of testosterone was tied to a 37% increased risk for type 2 diabetes and a 51% increased risk for polycystic ovary syndrome.

In men, however, a high testosterone level was linked to a 14% lower risk of developing type 2 diabetes, the findings showed.

"The findings in men that higher testosterone has a protective effect and reduces the risk of type 2 diabetes is news to me," Zonszein said. "This needs to be shown by other studies and its mechanism needs to be elucidated."

Dr Minisha Sood, an endocrinologist at Lenox Hill Hospital in New York City, said that testosterone may not be as protective in women because it converts to estradiol, which is related to the risk for breast cancer.

"High levels of testosterone in women have also been shown to increase visceral fat, which is linked to the components of metabolic syndrome," Sood said.

That men with high testosterone are at lower risk of developing type 2 diabetes is likely related to having more lean muscle mass, which improves insulin sensitivity and reduces the likelihood of type 2 diabetes, she said.

But Sood isn't a fan of men using testosterone supplements to ward off diabetes.

"Testosterone therapy comes with potential risks, including a high red blood cell count and higher rates of high-grade prostate cancer if a man is already predisposed to develop prostate cancer," she said.

Obese men or those with type 2 diabetes would benefit more from lifestyle changes to improve testosterone levels, namely, weight loss, healthy diet and exercise.

"This approach is preferred in that population over testosterone replacement whenever possible," Sood said.

The report was published in the journal Nature Medicine.

Image credit: iStock

Read the original here:
How high testosterone levels have different health outcomes for men and women - Health24

The 360 shows you diverse perspectives on the days top stories.

Whats happening

In the late 1950s, an American biologist named Gregory Pincus began researching how hormones might influence the female reproductive cycle and thus prevent pregnancy. In 1960, the first oral contraceptive was approved by the FDA.

Pincuss work led to one of the most important medical breakthroughs in modern history. Over the past 50 years, various forms of hormonal birth control have become so common theyre known simply as the pill. But Pincus didnt focus only on women. He also hoped to create a similar treatment for males. After minimal research, however, he abandoned the pursuit.

To this day, no male birth control product has made it to market. But over the past year, there has been promising early progress on new treatments including a pill, a gel thats rubbed onto the skin and an injection that acts as a nonsurgical vasectomy that could finally bring the first male contraceptive to the public. If that happens, research suggests a male pill could drastically reduce unplanned pregnancies, especially in developing countries.

Why theres debate

There are a number of factors that have prevented the creation of male birth control, some of them medical and others societal.

Part of the challenge comes down to simple biology. To interrupt fertility in a female body, a contraceptive needs to prevent a single egg from being fertilized, which can only occur in a limited time window. Males, on the other hand, create 1,500 sperm a second and are fertile at all times. Hormonal treatments in development are designed to limit sperm production by lowering testosterone levels. But the effects need to be calibrated just right. Testosterone levels need to be low enough to create infertility but they cant go so low as to cause side effects like decreased libido.

Beyond medical reasons, the development of male birth control has been hampered by a lack of interest by the pharmaceutical industry and rules about which side effects are permissible in drugs. A large clinical study in 2016 was halted after men in the trial reported serious side effects, including mood swings, altered libido and acne issues commonly associated with female birth control. Cultural factors, such as the notion that women are responsible for contraception, and fear that birth control would make men less masculine are also frequently cited as inhibiting research.

Whats next

Recent clinical trials of male contraceptives have shown promising results, but experts say it could be another 10 years or more before any of the drugs are made available to the public.

The female reproductive system is easier to disrupt with hormones

Female birth control is about preventing the fertilization of one ovum, primed for procreation once per month. Thats it. Male birth control requires wrangling millions of sperm produced constantly and en masse. Joshua A. Krisch, Fatherly

The burden of contraception falls on women

A big part of the answer is that, as a society, we consider the work of pregnancy prevention to be womens work. Katrina Kimport, Gizmodo

Pharmaceutical companies dont see male birth control as profitable

The thought is that industry pulled away from male contraceptive development due to concerns that the market was already saturated with female methods. Moving into the male market, where the risk profile is uncertain, was too risky. Dr. Jill Long, Inverse

Women face greater risks from pregnancies

The need for female contraceptives has been greater historically because pregnancy and childbirth can be dangerous, even life-threatening. Men face no similar danger, so medical regulators have had a much lower tolerance for risks caused by male contraceptives compared to female contraceptives. Julia Belluz, Vox

Finding the right balance of hormones is tricky

There's a challenge with hormonal birth control: suppressing testosterone in men to super-low levels while avoiding the side effects of low hormone levels, such as changes in sexual function. Michael Nedelman and Jamie Gumbrecht, CNN

Side effects are seen as less acceptable in male contraceptives

While certain symptoms are considered acceptable in female contraceptives, because they are weighed against the risks of pregnancy, they are often viewed as deal breakers for male contraceptives, because the comparison group is healthy young men. Lisa Campo-Engelstein, BBC

Men may not want to take it

Its not clear whether men would take a birth control pill: Some surveys show that men are reluctant, while others suggest the opposite. The most pervasive feeling might be apathy a sense of complacency because women are running the contraceptive show. Arielle Pardes, Wired

Is there a topic youd like to see covered in The 360? Send your suggestions to the360@yahoonews.com.

Cover thumbnail photo illustration: Yahoo News; photo: Jane Doe/Agency

Go here to read the rest:
Why isn't there a male birth control pill? - Yahoo Sports

MELBOURNE The fairness of transgender athletes competing in women's sports will be under the microscope in Australia on Sunday when New Zealand weightlifter Laurel Hubbard continues her bid to qualify for the Tokyo Olympics.

Hubbard, who competed in men's weightlifting competitions before transitioning seven years ago, will lift in the women's 87-plus kg division in the Australian Open in Canberra on Sunday.

She kept her Olympic hopes alive by winning last month's World Cup in Rome where she lifted 270kg, edging Ukraine's Anastasiia Lysenko by 4kg.

The Australian Open offers another chance for 42-year-old Hubbard to shore up ranking points in qualifying, which requires lifters to compete in at least six events in an 18-month period before the Games.

Hubbard is eligible to compete in women's events, according to the International Weightlifting Federation's guidelines for the inclusion of transgender athletes. She is also eligible to lift at Tokyo if she qualifies.

The International Olympic Committee's guidelines, issued in 2015, allow any transgender athlete to compete as a woman provided their testosterone levels are below 10 nanomoles per liter for at least 12 months before their first competition.

Some scientists have criticized the guidelines, saying they do little to mitigate the biological advantages of those who have gone through puberty as males, including bone and muscle density.

Sports like weightlifting, which place a premium on strength, are at the center of the debate.

Hubbard's participation in women's events has dismayed rival lifters and their coaches.

Her gold medal wins at the Pacific Games in Samoa last year, where she topped the podium ahead of Samoa's Commonwealth Games champion Feagaiga Stowers, triggered outrage in the island nation. [nL4N24V1GQ]

Australia's weightlifting federation sought to block Hubbard from competing at their home Commonwealth Games on the Gold Coast in 2018 but organizers rejected their bid.

Australian former track athlete Tamsyn Manou, who won three Commonwealth golds competing as Tamsyn Lewis from 1998-2006, said on Thursday that women needed to "take a stand" over the inclusion of transgender athletes in their sports.

"There's been a lot of people who are scared to come out and say anything because of political correctness," Manou told local radio station 2GB.

Qualifying for Tokyo would be a triumph for the media-shy Hubbard, who thought her weightlifting career was over after suffering a serious arm injury at the Gold Coast Commonwealth Games.

Coming back from surgery, she has had unwavering support from Olympic Weightlifting New Zealand for her Tokyo bid.

"Nothing has changed for us," Simon Kent, OWNZ's head of high performance told Reuters. "We are still following the same parameters we have since the get-go. We follow the IOC protocols and as Laurel said, she meets (them)."

(Additional reporting by Greg Stutchbury in Wellington; Editing by Gerry Doyle)

Link:
Transgender Weightlifter Hubbard Continues Tokyo Bid in Australia - The New York Times

A Canadian father of two is leading the way in parenting after he threw his trans son a party to celebrate the start of his testosterone treatment.

Dave Scott went viral as his innocent emoji-laden tweets about party preparations captured the hearts of everyone on social media.

So this month my 16yo son started testosterone, he wrote. Today hes throwing a 1 yr T-Versary.

My kitchen is full of teens playing beer pong and having mock-tails, and weve got the chocolate fountain going. Its a happy place. & Im worn out with running errands all day.

The story continued as the proud dad tweeted throughout the evening, cheerfully watching from the sidelines as the teens enjoyed homemade tacos and committed the curious food crime of onions in a chocolate fondue.

He included a message for other trans people watching: Lots of love to everybody out there. Remember, you guys are valid no matter how you transition or what your journey entails. And sometimes you cant transition, so stay safe everybody.

The party ended with cupcake decorating in trans flag colours of course and Scott finally got to take a picture with his son. Were touched by the love shared here, in Twitterverse, he wrote. Love is Love, Trans Rights are Human Rights.

Three cheers to Dave Scott for showing the world how easy it is to love and accept trans kids (although we think you couldve skipped the chocolate onion part).

Excerpt from:
Dad throws trans son a party to celebrate his transition and its the light we need in this dark, dark world - PinkNews

Erectile dysfunction (ED) is a commonly encountered problem that affects nearly 30 million American men. Although ED statistics increase with age, it doesnt have to really be a part of the aging process.

The World Health Organization recognizes sexual health as an integral state of physical, mental and social well-being in relation to sexuality. But, as they age, men can sometimes find it hard to keep it up. Age-related erectile dysfunction can be due to several underlying health conditions including diabetes, hypertension and heart diseases. Experts consider ED as the primary sign of a stroke or a heart attack too. ED could also be attributed to the lowering of testosterone with age, oxidation and age-related atrophies of nerve endings.

Here are some ways to slow down the process of ED:

1. Stay nourished

Needless to say, the key to delaying the aging process is a well-balanced diet. Consuming fresh and unprocessed foods including fruits, vegetables, nuts, whole grains, and legumes can supply all the nutrients and antioxidants that help counteract the aging process. When nitrates in the above-mentioned foods are converted to Nitrous oxide, it works along with other antioxidants to help stave off age-related damages to the blood vessels.

2. Trim down

Excess fat can reduce the levels of testosterone in the body and convert them into estrogens instead. It also releases certain toxic free-radicals that play a vital role in aging. Staying lean is thereby the only solution to prevent the above-mentioned mishaps

3. Keep Moving

Moderate-intensity exercises such as walking could help restore sexual performance in obese middle-aged men suffering from ED. Per the results of a Harvard study, 30 minutes of walking every day reduce ED risk by 41%.

4. Practice Kegel

The muscles around your penis might get weaker as you get older. Kegel exercises can help strengthen those muscles and help prevent ED. They are involved in keeping the blood trapped in the erection and during ejaculation. Practice them several times in a row and every day.

5. Take care of your vascular health

Health conditions such as hypertension, diabetes and high cholesterol can all cause damage to the arteries in the heart, brain and those that lead towards the penis. It is important to pay attention to your vascular health and get treated or make lifestyle changes if advised.

lifestyle changes to reverse erectile dysfunction Photo: PhotoMIX-Company, Pixabay

Original post:
5 Effective Ways To Prevent Age-Related Erectile Dysfunction - International Business Times

Jatenzo (testosterone undecanoate; Clarus Therapeutics), an oral testosterone replacement therapy, is now available for the treatment of hypogonadism.

Specifically, Jatenzo is indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone:

Jatenzo is not intended for use in males with age-related hypogonadism and its safety and efficacy have not been established in males <18 years old.

The treatment carries a Boxed Warning related to blood pressure (BP) increases that could potentially increase the risk of major adverse cardiovascular events. In a clinical trial, Jatenzo increased systolic BP during 4 months of treatment by an average of 4.9 mmHg based on ambulatory BP monitoring and by an average of 2.8 mmHg from baseline based on BP cuff measurements. For this reason, baseline cardiovascular risk should be considered before initiating therapy and BP should be adequately controlled. Among study patients treated with Jatenzo, 7% were started on antihypertensive medications or required intensification of their antihypertensive medication regimen during the 4-month trial.

Jatenzo, a Schedule III controlled substance, is available in 158mg, 198mg, and 237mg softgels. Dosage should be individualized based on serum testosterone concentrations.

Jatenzo offers patients a convenient softgel formulation, and eliminates the worry of gel transference, skin irritation from patches, or pain from injections that other testosterone treatments carry, said Dr Ronald S. Swerdloff, lead investigator of the inTUne trial, the pivotal study that established the safety and efficacy of the treatment.

For more information visit jatenzo.com.

This article originally appeared on MPR

See original here:
Jatenzo, an Oral Testosterone Replacement Therapy, Now Available - Renal and Urology News

Simple Man - YouTube YouTuber Simple Man ate 12 eggs every day for a whole week and lost weight, but also found that the diet increased his cholesterol and lowered his testosterone.

In addition to being a great, keto-friendly source of protein, eggs also contain amino acids essential to human nutrition and have been linked to decreased blood pressure and increased testosterone in men. Inspired by the strapping Gaston from Beauty & The Beast and his diet of three dozen eggs a day, YouTube's Simple Man decided to test how eating more eggs would affect his health, and started eating 12 eggs every day, using home testing kits to track changes in his blood pressure, cholesterol and testosterone.

At the beginning of the challenge, he weighs 205.4 pounds, with a body fat percentage of 20.7 and a 37.5 inch waist. His blood pressure is 127/87, and he has a cholesterol level of 253 mg/dL which is already pretty high. "I was completely unaware that my cholesterol was this high when I started the experiment," he says. "You can look fine to the eye, but with cholesterol you just never know."

He keeps his calorie intake the same each day at 2,000, with around 840 calories taken up by the 12 eggs. Each morning he eats them poached, then in the evenings he either scrambles or fries them, makes omelets, or improvises "egg tacos" to introduce a little novelty. "Towards the end of this experiment I was so sick of eggs I started to say screw it, I'm gonna get all 12 of these eggs in one meal," he says. "Honestly, by the end of this challenge I swore that I'd never eat another egg."

After eating 12 eggs a day for a whole week (that's 84 eggs), his weight had dropped by 3.8 pounds to 201.6, and his body fat had gone down by 0.8 percent. "My waist also saw a noticeable decrease in size in just 7 days, decreasing by one and a half inches," he says. "While eating eggs I did certainly notice that my midsection slimmed down and the amount of fat in this area definitely decreased."

However, while he achieved some pretty fast weight loss results, the dozen egg diet also had other effects on his body.

His blood pressure also changed from 127/87 to 120/88, and his testosterone actually dipped slightly. His already-high cholesterol went up even further, from 253 to 276 mg/dL, although he notes that there was an incremental increase in his good cholesterol HDL, which went from 48 to 52 mg/dL. However, his bad cholesterol went up too. "It's a good thing I stopped after one week because my cholesterol was not improving, it was only getting worse," he says.

Gallery: 20 reasons eggs could be your secret weight loss weapon (Eat This, Not That!)

More here:
This Is What Eating a Dozen Eggs a Day Does to Your Body - msnNOW

Chicago, United States, Feb 24, 2020 The Testosterone Booster Market report offers vital statistics on the market status which allows developing a full proof plan for unprecedented business growth. The valuable guidance helps businesses and individuals to gain key insights who are interested to cash out profits from the industry.

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TestofuelGNCTestoTEKPrime MaleTEK NaturalsTestoGenPrime MaleNugenixMonster TTestoRush

By Product Type:

by ComponentD Aspartic AcidVitamin D3Otherby SourceMucuna PruriensGinsengOyster ExtractFenugreekStinging Nettle

By Application Type:

TeenagersAdults

Key Regions covered in the report include:

Get a Sample PDF Report: https://www.reporthive.com/request_sample/2172691

The global Testosterone Booster market size is estimated at xxxx million USD with a CAGR xx% from 2015-2019 and is expected to reach xxxx Million USD in 2020 with a CAGR xx% from 2020 to 2025. The report begins from overview of Industry Chain structure, and describes industry environment, then analyses market size and forecast of Testosterone Booster by product, region and application, in addition, this report introduces market competition situation among the vendors and company profile, besides, market price analysis and value chain features are covered in this report.

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Originally posted here:
Testosterone Booster Market In-Depth Analysis by Region and Forecast by Application to 2025 | Testofuel, GNC, TestoTEK, Prime Male - Instant Tech News

In addition to being a great, keto-friendly source of protein, eggs also contain amino acids essential to human nutrition and have been linked to decreased blood pressure and increased testosterone in men. Inspired by the strapping Gaston from Beauty & The Beast and his diet of three dozen eggs a day, YouTube's Simple Man decided to test how eating more eggs would affect his health, and started eating 12 eggs every day, using home testing kits to track changes in his blood pressure, cholesterol and testosterone.

At the beginning of the challenge, he weighs 205.4 pounds, with a body fat percentage of 20.7 and a 37.5 inch waist. His blood pressure is 127/87, and he has a cholesterol level of 253 mg/dL which is already pretty high. "I was completely unaware that my cholesterol was this high when I started the experiment," he says. "You can look fine to the eye, but with cholesterol you just never know."

He keeps his calorie intake the same each day at 2,000, with around 840 calories taken up by the 12 eggs. Each morning he eats them poached, then in the evenings he either scrambles or fries them, makes omelets, or improvises "egg tacos" to introduce a little novelty. "Towards the end of this experiment I was so sick of eggs I started to say screw it, I'm gonna get all 12 of these eggs in one meal," he says. "Honestly, by the end of this challenge I swore that I'd never eat another egg."

After eating 12 eggs a day for a whole week (that's 84 eggs), his weight had dropped by 3.8 pounds to 201.6, and his body fat had gone down by 0.8 percent. "My waist also saw a noticeable decrease in size in just 7 days, decreasing by one and a half inches," he says. "While eating eggs I did certainly notice that my midsection slimmed down and the amount of fat in this area definitely decreased."

However, while he achieved some pretty fast weight loss results, the dozen egg diet also had other effects on his body.

His blood pressure also changed from 127/87 to 120/88, and his testosterone actually dipped slightly. His already-high cholesterol went up even further, from 253 to 276 mg/dL, although he notes that there was an incremental increase in his good cholesterol HDL, which went from 48 to 52 mg/dL. However, his bad cholesterol went up too. "It's a good thing I stopped after one week because my cholesterol was not improving, it was only getting worse," he says.

See the rest here:
Here's What Eating 12 Eggs a Day Did to This Guy's Body - menshealth.com

"I can be just as groovy as the next cat. But tattoos were never an option for me," Ray says in his latest column.

Face tatts are all the rage. And that's very confusing.

Look, Im no prude. I can be just as groovy as the next cat. But tattoos were never an option for me.

And a tattoo on my face makes no sense unless its of Brad Pitt. Still, Id rather be fitted with a nose bone.

I do not have a tattoo anywhere on my body, not even the words wide load. Its not like Im against them; I just dont feel the need to have some person use a needle to permanently and painfully color my skin.

Even so, Ive often wondered if I ever was in the mood to get one, what would it be and where would I get it? Theres Mom, but shes gone so she couldnt appreciate it. Besides, if I got it done while she was still here, shed get mad at me for wasting my money.

A lot of guys are nostalgic about their first car. But I didnt own a 67 Goat. So I cant see me getting a tatt of a Buick LeSabre. Talk about being a stone nerd.

And I certainly wouldnt get a Chinese symbol or barbed wire around my bicep, like some workout bro.

I suppose someone gets a tattoo to symbolize something that person enjoys or believes in. I enjoy my dog, but a tattoo of a beagle? I dont think so.

Some people use quaint sayings from poets or philosophers. But Im not that clever. My quotes are usually from people like Homer Simpson or from the movies like Was it over when the Germans bombed Pearl Harbor?

People who join the military are famous for getting tatts. And my son was no exception. He joined the Army when he just turned 18 and it was during the War on Terror. Of course, I was worried about other things like roadside bombs or him coming home with a baby.

As the Army bus pulled away, I stood there like a house by the side of the road, crying like a baby.

He never did go overseas but he did get a tattoo, a decision that involved a skull or something else brimming with testosterone and fueled by beer.

I dont have any piercings, either. Not really my style. I suppose I would get one if I was in a rock n roll band or if I was an artist like a sculpture maker. But Im too much of a square for pierced ears. And, really, it sounds painful. Poking holes in my body sounds wrong.

I suppose I could use a clip-on earring, but that would be a little awkward.

My mom used clip-ons but she said she was allergic to gold. Not me. I love gold. Just not in my ear.

So I think Ill go through the rest of life with a tattoo-less body and no additional, man-made holes. But that doesnt mean Im not hip.

I just prefer to express myself in other ways. Like a license plate. One that lets you know Ive got grandchildren and lots of stories about them. Cool, eh?

Ray Kisonas is regional editor for The Monroe News and The Daily Telegram. He can be reached at rayk@monroenews.com.

Read the original post:
Ray Kisonas: Tatts are great as long as they wash off - Monroe Evening News

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