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Primal Core Review Are you losing energy, strength and mass? This is quite common for men as we get older, but we dont want to give up without a fight. Do supplements really help you revitalize your sex life and your power of muscle development? Today we are going to see one of these supplements to find out. Its called Primal Core, and its formulated to support testosterone production and improve muscle building capabilities. If you are interested in getting more information about this supplement, continue reading about Primal Core Testosterone Support, a new support supplement for men who want to gain muscle mass and strength. But it works? Can you really gain muscle with that? That is what we are looking to answer in this review. Continue reading for more information on Primal Core Testosterone Booster.

Primal Core is a new testosteronecomplex for men. If you find it more difficult to exercise recently, it can bethe result of several causes. For example, you may have low testosterone. Youmay be malnourished or not eating well enough. It may be getting there at theage. But age is not everything. I see older boys in the gym all the time,killing him, so its not like you have 40 or 50 and youre bedridden. So how doyou keep dominating in the gym if you start feeling weaker? Well, you can readmore here about Hexofire Labs Detla Prime. The creator of this supplementstates that you can develop your body with this new supplement. But does itwork and is there any side effect? Find out below or click on the button to seewhich is the best qualified muscle supplement!

Are you trying to be scammed? Do youwant more mass or definition? Will a supplement really help you gain thatmuscle? Today we are looking at Primal Core. This is a supplement developed toincrease muscle mass, sexual desire, strength and hormone production. We willtake each of these in order. For muscle mass, you should really focus on yournutrition and training. Be sure to have a high protein diet that is diverse. HFLabs Primal Core is supposed to increase testosterone. This is an importantmale hormone, for sexual and physical function. But can testosterone help youincrease muscle mass? According to a study conducted in 1996, testosteronereplacement stimulated muscle protein synthesis, but only in hypogonadal men.If you dont have low testosterone levels, testosterone supplements probablywont do much.

Unfortunately, we have not discoveredmany testimonials online. If you want to search yourself to see if there arecustomer comments, continue. It is a good way to find out what you can expectfrom a supplement. Nor do we have access to the primary basic ingredients,which is unfortunate because that can tell you a lot about a supplement.Exercising and gaining muscle is primarily about the nutrition and exercisethat you have developed. If you have these things below, you may be looking forother options to increase your performance. Well, there is not much evidencethat these supplements really work, but you can always try it yourself to findout if you like it!

1. Be consistent: you wont feelshattered if you run out in the gym once a month. The best approach is to goevery two days doing reasonable workouts with incremental increases inintensity.

2. Do cardio: it is not very healthyjust for weight training. You should also combine those workouts with cardio.

3. Call a friend: exercising withsomeone who knows what you are doing will have a great influence on you. Youwill see more success and have a more pleasant experience overall too!

Do you want to try Primal CoreTestosterone Booster? Simply search for the product online. You should be ableto find the product easily and order it online. They may have a test option,but if they have one, be sure to read the terms and conditions. Sometimespeople can get confused with the terms of the agreement and end up withsomething they dont want. You can also click on one of the buttons on thispage to see testosterone # 1 supplement.

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Primal Core - The #1 NEW Testosterone Booster? Is It Worth ... - Knnit - Knnit

Experts say these are the most effective ways to lose weight after 50

There's no reason you can't look as fit and fabulous at 50 as you did at 40.

But there is one hitch: Even stars with personal trainers and nutrition coaches have to work a little harder to lose the pounds once they hit this milestone age.

One of the main reasons you'll have to put in extra effort: Your body composition changes as you age. You lose muscle mass at an average rate of 3-5% for every 10 years after age 35, and this can impact the way you burn fat. Your body goes into its aging stage as it leaves the growing one, says Dr. Luiza Petre, a New York City-based weight loss and management specialist, and assistant clinical professor of cardiology at the Mount Sinai School of Medicine. When this happens, your body doesnt need as much energy as it used to, she explains.

What's more, all those years of playing sports, running after your kids and walking up and down stairs take their toll. You may notice that your joints are a little stiffer and your muscles are a little sorer than they were a few decades ago. Then, there's the issue of your ever-evolving metabolism.

According to the American Council on Exercise, your resting metabolic rate, a.k.a. your body's ability to burn calories while sitting on the sofa doing nothing, decreases by about 1-2% per decade due to muscle mass loss and increased fat mass. Our diets usually don't change enough to account for this metabolic adjustment, meaning weight can creep up slowly but surely with every birthday.

"There are a number of roadblocks people in their 50s will face when trying to lose weight," says Brian Durbin, a NSCA-certified strength and conditioning specialist and personal trainer. "But once you know what they areand how to work around themit's easy to be successful at dropping pounds."

One of the best things you can do at any age is shake up your routine and try something new. Follow these tips to help you drop the pounds, and keep them off for good, courtesy of some of the worlds best weight-loss experts, dietitians and personal trainers

First stop after you celebrate the big 5-0your doctor's office. Your doctor can assess your current state of health, address any health problems that may be affecting your weight (like pre-diabetes or sleep apnea) and help you come up a plan for diet and exercise, says Dr. Petre. Your doctor may even be able to recommend a physical therapist or personal trainer for you.

Have your doctor check your hormone levels. As we age, progesterone, testosterone and other hormones decline, which sets the body up for storing fat instead of losing weight, says Dr. Jennifer Burns, a naturopathic physician in Phoenix. "Simply getting your thyroid, adrenal glands and other hormone levels checkedand then taking the appropriate steps to bring them back into balancecan go a long way toward helping people in their 50s lose weight," says Burns.

Dr. Tami Meraglia, author of The Hormone Secret: Discover Effortless Weight Loss and Renewed Energy in Just 30 Days, agrees, adding that she believes the hormone to focus on is testosteroneespecially for women over 50 who are trying to get fit. "There is ample discussion in the medical community about the effects of estrogen loss, but few people are aware of the importance of sufficient testosterone levels, which can help a woman slim down," says Dr. Meraglia. In fact, research shows that balanced testosterone levels reduce blood glucose levels, which may help promote weight loss and shrink stubborn belly fat.

Declaring that youre going to lose 20 pounds before your beach vacation next month is unrealistic, not to mention unhealthy. Be honest with yourself. How do you feel? How healthy are you? Making life changes takes courage and mental fortitude, says Dr. Petre. Break up big goals into smaller, more achievable ones. Focusing on how you're feeling and the positive changes you're making to your lifestyle, instead of the number on the scale, will help you stay motivated to reach your goals. Triumphs make your courage grow, she adds. Small achievements amount to large goals achieved.

There are dozens of different eating plans buzzing around the internet, each claiming to help you shed the pounds without feeling deprived (some of best diets for weight loss in 2020 are the Mediterranean Diet, the DASH Diet and WW Freestyle). If you're not sure which one works best for your lifestyle, talk to a dietitian, who can break down the pros and cons and help you choose one that fits your nutritional needs and goals. An RD will also give you ideas on how to resolve road blocks that may get in the way of your goals, like emotional/stress eating, food sensitivities, nutritional deficiencies and meal-prep fatigue.

At 50, you've been around the block enough times to know that fad diets don't work. No crazy fasts, cleanses, cutting out fats or complex carbohydrates or proteins, says Jillian Michaels, health and wellness expert and author of The 6 Keys: Unlock Your Genetic Potential for Ageless Strength, Health and Beauty. Instead, consider following a medically supervised, clinically proven plan. Dr. Petre explains that these types of programs have a weight-loss success rate of more than 75%, especially if they involve personal support and weekly check-ins.

Even if you've never picked up a dumbbell in your life, now is the perfect time to learn to love the weight room (but seriously, if you're a newbie, work with a trainer first so you don't hurt yourself!). Because the secret to losing weight over 50 is this: Build more muscle mass to increase your metabolism (you've got about 20% less now than you did when you were 20). "The good news is you can turn all of this around with a well-structured weight-training routine," Durbin says. "That can help you regain the ability to lose weight like you were able to 20 years ago," he says. Aim to lift weights at least twice a week, whether you use free weights or machines or do bodyweight exercises. It doesn't hurt to lift every dayjust make sure to work different muscle groups or train differently each day.

Janna Lowell, a Los Angelesbased personal trainer, says she gets the best results among her 50-somethings when she has them do some cross training in the pool. Tired joints can keep you from getting a great workout, she says, and aches and pains can turn some people off exercise completely. "Water exercise is easy on the joints and can boost range of motion as well," says Lowell. "Even better, caloric expenditure is about 30% greater in the water than on land due to the resistance water creates." No pool? No problem. Walking is another great, low-impact cardiovascular exercise, as are cycling, kayaking, yoga and dancing.

If you're going to put in the effort to block out the time, don't let your exhaustion or aching joints hold you back from going all out! Alex Allred, a former national and professional athlete turned personal trainer, says this is one of her biggest pet peeves among 50-year-olds. "Far too many people think that just because they showed up, they're working out," says Allred. "But really, you need to be focused on what you're doing and pushing yourself hard enough to break a sweat or at least complete the full range of motion of a certain exercise." Not sure if you're doing a move properly? Ask! "I wish more people would flag down a trainer and ask, 'Am I doing this correctly?'" says Allred. It can make the difference between making the most of your exercise time to lose weight and wasting your time or injuring yourself.

If an aching back, wonky knee or creaky hip has kept you from working out on a regular basis, make an appointment with a physical therapist, suggests Samira Shuruk, an ACE-certified personal trainer. "After 50, many people have sustained injuries and don't know what their activity options are," she says. "Getting advice from a professional can truly help." Physical therapy can also help you rehabilitate an old injury or ease joint and muscle pain, setting you up for pain-free workouts.

Just like pop music isn't the same as it was when you were in your 30s, your metabolism has changed, too, which means you're burning about 250 fewer calories each day. So if you continue to eat like you did in the early 2000sand don't increase your exerciseyou'll inevitably gain weight, says Dr. Katie Ferraro, a registered dietitian and assistant clinical professor of nutrition at the University of CaliforniaSan Francisco School of Nursing. Eliminating the junk food in your diet and replacing it with loads of fruits, vegetables, whole grains and lean proteins can make cutting calories painless, she says.

Its not just what you eat, but how you eat that matters in your 50s, claims Dr. Anthony Dissen, a registered dietitian nutritionist and Vice President of Nutrition at WellStart Health. He suggests focusing on fullness, not portion control, when you are planning your meals. If our stomachs arent full, we dont feel full, and well stay hungry, he points out. When it comes to healthy weight loss and management, we want to strike that important balance between eating until we feel full and satisfied while still decreasing our overall calorie intake.

Between paying college tuition for your kids, juggling more and more responsibilities at work and dealing with aging parents, your 50s can be a prime-time for stress, says Durbin. The result? Emotional eating and a schedule that seems too jam-packed for regular exercise sessions. The solution: Schedule your workouts like they're doctor's appointments, he says. Sticking to a consistent routine can not only help ease stress, it can also help you stay on track with your diet. After all, who wants to ruin the benefits of a tough sweat session by eating a donut?

One great thing about being 50you are completely over the social pressure to stay out late. Doing your best to get seven to eight hours of snooze time every night is key to helping you lose weight, says Michaels. Dr. Petre adds that the two hormones that regulate appetiteleptin and ghrelingo into overdrive without regular shut-eye. This can trigger excessive hunger and lead to poor food choices and weight gain at any age, she says. Find a list of proven of sleep strategies right here.

Its important to practice mindfulness, especially when youre eating. The more we try to multi-task while we eat, the more likely we are to overeat and not feel as satisfied by the meal or snack weve just eaten, Dr. Dissen explains. By simply taking a breath and treating our mealtime as special, it allows us to really taste our food and notice its flavors, textures and tastes. Mindfulness can aid in stress relief, too. Michaels suggests practicing five to 10 minutes of meditation a day.

Whether it's treating yourself to manicure or taking a mental health day from work, taking care of yourself shouldn't be looked at as a luxury. The smallest gestures can make a big difference in reducing stress, which can make a big impact on your weight loss. Plus, when you show yourself a little more love, you can use that energy to do things that support your goals, like eating healthy, exercising and meditating. Not sure how to start a self-care routine? First ask yourself why you need more time to take care of yourself. Are you working too many late hours at the office? Do you feel burned out and wish you could be calmer? Once you figure out why you need to make some more time for yourself, it can help you decide what will be a good activity or routine for you.

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Experts say these are the most effective ways to lose weight after 50 - The Advocate

ENGLEWOOD, CO / ACCESSWIRE / February 6, 2020 / Aytu BioScience, Inc. (AYTU), a specialty pharmaceutical company focused on commercializing novel products that address significant patient needs, today announced that the company will present its operational results for the quarter ended December 31, 2019 on February 13, 2020, at 4:30 p.m. ET. The company will review accomplishments from the quarter and provide an overview of its business and growth strategy.

Conference Call Information

1- 844-602-0380 (toll-free)

1- 862-298-0970 (international)

The webcast will be accessible live and archived on Aytu BioScience's website, within the Investors section under Events & Presentations, at aytubio.com, for 90 days.

A replay of the call will be available for fourteen days. Access the replay by calling 1-877-481-4010 (toll-free) and using the replay access code 57940.

About Aytu BioScience, Inc.

Aytu BioScience is a specialty pharmaceutical company focused on commercializing novel products that address significant patient needs. The company currently markets a portfolio of prescription products addressing large primary care and pediatric markets. The primary care portfolio includes (i) Natesto, the only FDA-approved nasal formulation of testosterone for men with hypogonadism (low testosterone, or "Low T"), (ii) ZolpiMist, the only FDA-approved oral spray prescription sleep aid, and (iii) Tuzistra XR, the only FDA-approved 12-hour codeine-based antitussive syrup. The pediatric portfolio includes (i) AcipHex Sprinkle, a granule formulation of rabeprazole sodium, a commonly prescribed proton pump inhibitor; (ii) Cefaclor, a second-generation cephalosporin antibiotic suspension; (iii) Karbinal ER, an extended-release carbinoxamine (antihistamine) suspension indicated to treat numerous allergic conditions; and (iv) Poly-Vi-Flor and Tri-Vi-Flor, two complementary prescription fluoride-based supplement product lines containing combinations of fluoride and vitamins in various for infants and children with fluoride deficiency. Aytu's strategy is to continue building its portfolio of revenue-generating products, leveraging its focused commercial team and expertise to build leading brands within large therapeutic markets. For more information visit aytubio.com.

Forward-Looking Statements

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, or the Exchange Act. All statements other than statements of historical facts contained in this presentation, are forward-looking statements. Forward-looking statements are generally written in the future tense and/or are preceded by words such as ''may,'' ''will,'' ''should,'' ''forecast,'' ''could,'' ''expect,'' ''suggest,'' ''believe,'' ''estimate,'' ''continue,'' ''anticipate,'' ''intend,'' ''plan,'' or similar words, or the negatives of such terms or other variations on such terms or comparable terminology. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially. These risks and uncertainties include, among others: the effects of the business combination of Aytu and the Commercial Portfolio and the previously announced, but not yet consummated, merger ("Merger") with Innovus Pharmaceuticals, including the combined company's future financial condition, results of operations, strategy and plans, the ability of the combined company to realize anticipated synergies in the timeframe expected or at all, changes in capital markets and the ability of the combined company to finance operations in the manner expected, the diversion of management time on Merger-related issues and integration of the Commercial Portfolio, the ultimate timing, outcome and results of integrating the operations the Commercial Portfolio and Innovus with Aytu's existing operations, the failure to obtain the required votes of Innovus' shareholders or Aytu's shareholders to approve the Merger and related matters, the risk that a condition to closing of the Merger may not be satisfied, that either party may terminate the merger agreement or that the closing of the Merger might be delayed or not occur at all, the price per share utilized in the formula for the initial $8 million merger consideration in the Merger may not be reflective of the current market price of Aytu's common stock on the closing date, potential adverse reactions or changes to business or employee relationships, including those resulting from the announcement or completion of the Merger, risks relating to gaining market acceptance of our products, obtaining or maintaining reimbursement by third-party payors, the potential future commercialization of our product candidates, the anticipated start dates, durations and completion dates, as well as the potential future results, of our ongoing and future clinical trials, the anticipated designs of our future clinical trials, anticipated future regulatory submissions and events, our anticipated future cash position and future events under our current and potential future collaboration. We also refer you to the risks described in ''Risk Factors'' in Part I, Item 1A of the company's Annual Report on Form 10-K and in the other reports and documents we file with the Securities and Exchange Commission from time to time.

Story continues

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Aytu BioScience to Report Fiscal Q2 FY 2020 Results and Business Update - Yahoo Finance

The goal of Global Testosterone Replacement Therapy market research report is to provide the users a complete picture of the Testosterone Replacement Therapy market during the forecast period from 2020-2026 The global Testosterone Replacement Therapy market report provides the key market insights and the growth-inducing factors. It also does the comprehensive study of Testosterone Replacement Therapy Industry based on market gains, market volume, key industry sections of Testosterone Replacement Therapy which are differentiated based on product type, product application, major geographical regions contributing to the development of Testosterone Replacement Therapy market.

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AbbviePfizerEli LillyTeva PharmaceuticalsMylanBayer Healthcare PharmaceuticalsAntares PharmaFerring PharmaceuticalsAllerganAntares PharmaSandozClarus TherapeuticsJuniper PharmaceuticalsEndo InternationalAcerus PharmaceuticalsForendo PharmaMetp PharmaRepros Therapeutics

Global Testosterone Replacement Therapy market enlists the vital market events like Testosterone Replacement Therapy product releases, technical developments and groundbreaking market schemes of Testosterone Replacement Therapy which will help the readers to identify opportunities and risk factors which affect the development. Worldwide Testosterone Replacement Therapy market report covers chief market segments based on product type, product application, potential users and key zones.

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GelsInjectablesPatchesOther

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HospitalsClinicsOther

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Europe (Germany, France, Italy, Russia and UK)

North (Canada, USA and Mexico)

Latin America (Middle and Africa)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Asia-Pacific (South-east Asia, China, India, Korea and Japan)

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Element 1, enlist the goal of global Testosterone Replacement Therapy market covering the market introduction, product image, market summary, development scope, Testosterone Replacement Therapy market presence;

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Element 4, conducts the region-wise study of the global Testosterone Replacement Therapy market based on the sales ratio in each region, and market share from 2015 to 2020;

Element 5,6,7,8 and 9 demonstrates the key countries present in these regions which have revenue share in Testosterone Replacement Therapy market;

Element 10 and 11 describes the market based on Testosterone Replacement Therapy product category, wide range of applications, growth based on market trend, type and application 2015 to 2020;

Element 12 shows the global Testosterone Replacement Therapy market plans during the forecast period from 2020 to 2026 separated by regions, type, and product application.

Element 13, 14, 15 mentions the global Testosterone Replacement Therapy market sales channels, market vendors, dealers, market information and study conclusions, appendix and data sources.

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Testosterone Replacement Therapy Market- Revenue, Research Till 2026 Industry Influence Over Market - Reporting 99

Ive read that some Evangelical Christians and President Donald Trump think hes been chosen by God as president. I agree, for a different reason.

Perhaps its more than a coincidence that we had Trump, Harvey Weinstein, Jeffrey Epstein, Jerry Sandusky, Bill Cosby and the massive clergy scandal all seeing sunlight at about the same time.

Finally, the centuries of testosterone-infused patriarchy and power and exploitation of 50% of the human race and children are getting exposed.

This isnt about conservative, liberal or political parties. Its right vs. wrong and the age-old struggle of good vs. evil. The transactional, self-serving leadership of Trump, the dogmatic clericalism baked into the Catholic hierarchy, and the modern golden calf of vast wealth are more like making pacts with the devil. Free speech and the press are essential to call them out so we can deal with these crimes against humanity and country.

The last person to get exposed in the aforementioned cast is Trump.

We have seen what happens to countries ruled by despots.

Who would ever think Congress would prop up our very own version of the rambling Khaddafi?

They are good at taking out other countries crazy men but are afraid to stand up to our own because of retaliation?

This is a soul-crushing time. A criminal in the White House, and guns in the schools and church.

Some free country we have here.

Anita Altman

Johnstown

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Letter to the editor | A soul-crushing time in America - TribDem.com

The grimy and exhausted foot soldier, a cigarette dangling from the lips, is a complicated and irresistible force in movies and in life.

Prediction: War movies will outlast every other Hollywood genre, because we keep having wars. They provide abject lessons in cruelty and courage. Often, there are heavy doses of moral ambiguity, which Hollywood likes almost as much as sex. (Come to think of it, when was the last time you saw a truly sexy movie?)

Point is, war movies frighten and inspire us. Most of them are anti-war movies in that they powerfully remind us of the horrors of combat.

Where does this years Oscar front-runner, 1917, rank with the best of them? Certainly, Id put it in my top 10, based on its novel camerawork and overall impact. It has that ultimate trait all the great ones do, in that you cant get it out of your head, even days later.

Our ranking criteria: WWI and beyond, with a battlefield component. Like all masterpieces, our movies have a look all their own. And, obviously, amazing lasting power.

I dont want to start a war, but Id put Apocalypse Now at No. 1. And look at how low I ranked Saving Private Ryan. Im expecting flak on that one.

1. Apocalypse Now (1979). The raw guitar licks, the smell of napalm in the morning. This legendary film is where mayhem meets moral ambiguity. How can combat, the most immoral of all acts, have any ethics whatsoever? How far can emotional detachment go before evil intrudes? Stuff like that. The hippest, most distinctive and influential masterpiece.

Capt. Willard (Martin Sheen) warily surveys a temple compound in Apocalypse Now.

(United Artist)

2. The Longest Day (1962). A near-biblical look at the sweaty brawls of combat, during one of the most pivotal days in world history. Is this the most amazing and bullheaded male cast ever: John Wayne, Robert Mitchum, Henry Fonda, Richard Burton? No wonder it required multiple directors.

3. The Dirty Dozen (1967). The audacious premise: Even a bunch of notorious psychos can have a good moment. More than a cheer-along attack on a Nazi officers retreat, The Dirty Dozen is a study in leadership, muddy testosterone and redemption. It also boasts the best ending in movie history, edging out Casablanca and The Wizard of Oz.

4. The Deer Hunter (1978). I could watch this troubling movie a million times, if only to admire the way Meryl Streep turns demurely away from a lens at points when every other actor would turn toward it. What elevates this, besides another astounding cast, is the overlap between home life and combat. It also raises the question: Wasnt De Niro, at 35, better when he didnt worry so much about being De Niro?

The Deer Hunter starring, from left, Christopher Walken, John Cazale and Robert De Niro.

(Universal Studios)

5. Downfall ( 2004 ). Playing Adolf Hitler in his final hours, Bruno Ganz gives one of the most memorable performances in film history. Taut, gory and tragic, Downfall explores Hitlers human side and the hold he had over his followers, which makes him even more of a cautionary monster. A bold and brilliant film, start to finish.

6. 1917 (2019). At first a buddy film, it quickly becomes a study in the deepest reserves of battlefield bravery. Shot compellingly through foxholes and across rivers in what appears to be one extended take. You cant get the question out of your head: Why do directors bother so much with multiple angles when the one perfect shot is all you ever need?

7. Das Boot (1981). Tingles on the back of the neck; the heart beats faster with every passing minute of this German U-boat saga. As with most of these war movies, the tension and anticipation seem to close in on the audience. Das Boot does what every gripping war movie does: It makes you say, Get me the hell out of here.

8. Hacksaw Ridge (2016). This highly underrated look at pacifism and courage under fire boasts perhaps the most horrid war scenes ever. But what a story. And what a performance by Andrew Garfield. How did this great film not win a single major Academy Award? #oscarssolame

9. Saving Private Ryan (1998). Overrated, though certainly one of the 10 best. It seems to lose its mojo after the first 20 minutes. But what a 20 minutes they are.

10. MASH (1970). This playful and cocky attack against toxic authority, and unjust wars, is nothing but fun. Should war movies ever be fun? In the right hands, yes. Because satire is still the sharpest sword.

Honorable mentions: The Bridge on the River Kwai (1957), Patton (1970), The Great Escape (1963), The Thin Red Line (1998), Full Metal Jacket (1987), Platoon (1986), Tora! Tora! Tora! (1970), Flags of Our Fathers (2006), Stalag 17 (1953), Black Hawk Down (2001), Stalingrad (1993), Paths of Glory (1957), All Quiet on the Western Front (1930), Kellys Heroes (1970), Battleground (1949).

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Column: '1917' is one of the best war movies ever. Here are my top 10 - Los Angeles Times

Global Endocrinology Drugs Market 2020-2024 The analyst has been monitoring the global endocrinology drugs market and it is poised to grow by USD 24. 78 bn during 2020-2024, progressing at a CAGR of 7% during the forecast period.

New York, Feb. 04, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Endocrinology Drugs Market 2020-2024" - https://www.reportlinker.com/p03793964/?utm_source=GNW Our reports on global endocrinology drugs market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors. The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by increase in incidence of endocrine disorders. In addition, association between obesity and endocrine disorders is anticipated to boost the growth of the global endocrinology drugs market as well.

Market Segmentation The global endocrinology drugs market is segmented as below: Therapy area Diabetes Drugs Thyroid Hormone Disorder Drugs HGH Testosterone Replacement Therapy Others

Geographic segmentation North America Europe Asia ROW

Key Trends for global endocrinology drugs market growth This study identifies association between obesity and endocrine disorders as the prime reasons driving the global endocrinology drugs market growth during the next few years. Prominent vendors in global endocrinology drugs market We provide a detailed analysis of around 25 vendors operating in the global endocrinology drugs market, including some of the vendors such as Abbott Laboratories, AbbVie Inc., AstraZeneca Plc, Eli Lilly and Co., GlaxoSmithKline Plc, Groupe Sanofi, Merck & Co. Inc., Novartis International AG, Novo Nordisk AS and Pfizer Inc. The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.Read the full report: https://www.reportlinker.com/p03793964/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The Global Endocrinology Drugs Market is expected to grow by USD 24.78 bn during 2020-2024, progressing at a CAGR of 7% during the forecast period -...

Teens with obesity and polycystic ovary syndrome (PCOS) have decreased bacterial diversity and a more "unhealthy" gut microbiome compared to similar-sized teens without PCOS, according to a new study published online January 23 in the Journal of Clinical Endocrinology & Metabolism.

"We have for the first time demonstrated that obese adolescents with PCOS have an altered gut microbiome compared to girls without PCOS with similar body mass index (BMI), activity level, and dietary habits," write Beza Jobira, MD, and colleagues.

Jobira is affiliated with Children's Hospital Colorado, Anschutz Medical Campus, in Aurora.

Researchers also observed that higher testosterone levels, which are often found in women with PCOS, were linked to decreased bacterial diversity in the gut.

"The unhealthy bacteria [were] related to higher testosterone concentrations and markers of metabolic complications. The gut microbiome may play a role in PCOS and its related metabolic complications, and these changes can be found in teenagers who are early in the course of the condition," senior author Melanie Cree-Green, MD, PhD, also of Children's Hospital Colorado, said in a press release issued by The Endocrine Society.

"Further work is needed to better understand the relationship between androgens and the microbiome, especially as a potentially new avenue for therapy," the authors write.

PCOS affects about 6%-18% of women worldwide but is more common among teenagers who are obese and typically starts in adolescence. Individuals affected by the hormonal condition show a range of symptoms, including acne, excess body hair, and irregular periods.

The condition is linked to increased risk for cardiometabolic conditions including type 2 diabetes and cardiovascular disease, as well as nonalcoholic fatty liver disease (NAFLD), infertility, and depression.

"Despite the increased risk of obesity and metabolic syndrome in women with PCOS, there are limited data linking altered gut microbiota to PCOS," the researchers say.

"Our goal was thus to determine if youth with PCOS and obesity have altered composition of gut microbiota compared to equally obese girls with regular menstrual cycles. This information could provide additional directions to improve treatment and prevention of PCOS," they write.

To study the issue, they conducted a prospective, case-control, cross-sectional study that included 58 teens who were obese and sedentary with an average age of 16 years. Participants were from pediatric endocrinology and lifestyle medicine outpatient clinics at the Children's Hospital Colorado.

The teenagers self-reported dietary and physical activity on standardized questionnaires. Laboratory tests included fasting glucose, sex hormone levels, alanine aminotransferase (ALT, a measure of liver function), inflammatory markers, and lipid levels. Researchers analyzed stool samples for bacterial genetic material.

Compared to participants without PCOS (n = 21), teens with PCOS (n = 37) had significantly decreased -diversity, a measure of bacterial diversity within each individual participant (Shannon diversity, P = .045 and evenness, P = .0052).

"By closely matching our control and PCOS groups for BMI z score, which is a measure that is adjusted for age, as well as having a very similar absolute BMI, we were able to detect differences based on disease status without the confounder of weight," the researchers observe.

The PCOS group also had significantly decreased -diversity, a comparison of overall bacterial composition between the two groups (P < .001).

Results also showed a higher percentage relative abundance (%RA) of phyla Actinobacteria (P = .027), lower Bacteroidetes (P = .004), and similar Firmicutes and Proteobacteria in the PCOS group compared with the non-PCOS group.

These four types of bacteria make up the majority of the gut microbiome, the researchers explain.

Changes in the relative abundance of these bacteria have been linked to a high-fat, low-fiber diet, as well as conditions associated with PCOS, including obesity, insulin resistance, type 2 diabetes, NAFLD, and inflammation in general.

In this study, lower Bacteroidetes was linked to a 4.4 increased likelihood of having PCOS.

Laboratory tests also showed that higher testosterone levels were significantly associated with decreased -diversity (P < .001).

A range of bacteria were linked to markers of metabolic syndrome, such as waist-to-hip ratio, fasting triglycerides, fasting insulin, and insulin sensitivity.

The study had several limitations. Not all lab tests were available for all participants because they came from three different studies with varying study designs. The study was relatively small, took place at a single tertiary care center, and did not include normal weight individuals with PCOS.

The study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, Doris Duke Foundation, Boettcher Foundation Webb-Waring award, University of Colorado GI and Liver Innate Immune Program, Center for Women's Health Research, and National Institutes of Health/National Center for Advancing Translational Sciences. The authors have reported no relevant financial relationships.

J Clinical Endocrinol & Metabol. Published online January 23, 2020. Abstract

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Gut Microbiome Is Less Diverse in Teens With Obesity and PCOS - Medscape

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Testosterone Replacement Therapy Market 2020-2027 is booming in forthcoming year by Leading Players AbbVie - Briotainment

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Testosterone Replacement Therapy Market is Estimated to Grow at the Highest Growth Rate till 2020-2024 - Expedition 99

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