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Testim VS Androgel – Testosterone Replacement Therapy
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The two major testosterone gel brands are Testim and Androgel. They are very similar and generally prescribed interchangeably, but sometimes insurance wont cover one or the other. Often, I hear that they wont cover Testim and people want to know if Androgel is just as good. So here is a general guide to choosing if you are lucky enough to have the choice which one is right for you.
Testim Vs AndrogelI would try whichever your insurance covers first. If your insurance covers both medications, try whichever one has coupons or kickbacks. Ive heard people say they didnt pay any/much for Testim for the first year because the company (Auxilium) that markets the drug has a financial assistance program available for the first year.
Now that price and availability are out of the way, lets deal with smell: Testim smells. Some people think it smells good, and some cant stand it. Personally, I like it and my wife likes it. Ive found that women ask me what cologne Im wearing, and mention that they like it too. Still, if you or your wife dont like the smell of something you have to put on every day, that would be a deal-breaker. So try out a tube and see what you and, if applicable, your partner thinks about the Testim scent. Androgel doesnt have much of a smell at all.
Testim is sticky. Androgel goes on much like that hand-sanitizer stuff, while Testim seems to remain stickier longer. Some say this is why Testim seems to work better for them: Because it stays on the skin and soaks in better. These personal statements of efficacy cant be relied on as empirical data, however. But the fact that you can feel it on your skin longer, does bring up a question about Testim gel Vs Androgel: Does it take longer to soak in and, if so, does that increase the exposure time I have to worry about when it comes to my wife and children? The short answer is: NO. In-fact, according to US National Library of Medicines website, the wait-time for AndrogGel is much longer:
You should not shower, bathe, swim, or wash the place where you applied the medication for at least 2 hours after you apply Testim gel or at least 5-6 hours after you apply AndroGel .
WasteTestim comes in little single-use tubes so you go through more of them and it generates more waste. If you are eco-minded this may factor into your decision. Androgel comes in a dispenser with a little pump on it (like soap) so there is less waste.
But the real question when considering AndroGel Vs Testim is: Which works better? Which is the best? Which testosterone topical gel is going to get my testosterone levels on track fast, keep my levels steady, and keep me there for the long term since Ill be taking this stuff for many years to come? As you might guess, both brands have their fans. Personally, I like Testim. And here is a study to back up my personal preference:
Efficacy of changing testosterone gel preparations (Androgel or Testim) among suboptimally responsive hypogonadal men.Grober ED, Khera M, Soni SD, Espinoza MG, Lipshultz LI.Division of Urology, Mount Sinai Hospital and Womens College Hospital, University of Toronto, Toronto, ON, Canada.Summary of the study:
A change in testosterone gel preparation among initially unresponsive hypogonadal men is justified prior to abandoning or considering more invasive TRT. Changing from Androgel to Testim offers hypogonadal men the potential for improved clinical and biochemical responsiveness. Changing from Testim to Androgel is indicated to eliminate or minimize unwanted side effects.
Note: This study was done to find out if switching brands would help men who were unresponsive to one brand or the other.
More important to me than such a study is to find out from others who have been on TRT for more than a year, preferably several years or more, and hear about their experiences with both or either drug. Please comment below with your own experiences.
I am inclined toward a weekly injection over a daily application, but what does ones rear-end feel like after being used as a pin-cushion for decades? I dunno any bodybuilders out there want to elaborate on that?
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Testim VS Androgel - Testosterone Replacement Therapy
Testosterone Deficiency, Erectile Dysfunction, and …
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Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics. Testosterone is also important for maintaining muscle bulk, adequate levels of red blood cells, bone growth, a sense of well-being, and sexual function.
Inadequate production of testosterone is not a common cause of erectile dysfunction; however, when ED does occur due to decreased testosterone production, testosterone replacement therapy may improve the problem.
As a man ages, the amount of testosterone in his body naturally gradually declines. This decline starts after age 30 and continues throughout life. Some causes of low testosterone levels are due to:
Without adequate testosterone, a man may lose his sex drive, experience erectile dysfunction, feel depressed, have a decreased sense of well-being, and have difficulty concentrating.
Low testosterone can cause the following physical changes:
The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. Because testosterone levels fluctuate throughout the day, several measurements will need to be taken to detect a deficiency. Doctors prefer, if possible, to test levels early in the morning, when testosterone levels are highest.
Note: Testosterone should only be used by men who have clinical signs and symptoms AND medically documented low testosterone levels.
Testosterone deficiency can be treated by:
Each of these options provides adequate levels of hormone replacement; however, they all have different advantages and disadvantages. Talk to your doctor to see which approach is right for you.
Men who have prostate cancer or breast cancer should not take testosterone replacement therapy. Nor should men who have severe urinary tract problems, untreated severe sleep apnea or uncontrolled heart failure. All men considering testosterone replacement therapy should undergo a thorough prostate cancer screening -- a rectal exam and PSA test -- prior to starting this therapy.
In general, testosterone replacement therapy is safe. It is associated with some side effects, including:
Laboratory abnormalities that can occur with hormone replacement include:
If you are taking hormone replacement therapy, regular follow-up appointments with your doctor are important.
Like any other medication, directions for administering testosterone should be followed exactly as your doctor orders. If you are unsure or have any questions about testosterone replacement therapy, ask your doctor.
SOURCE:
Get-Back-On-Track.com.
The Hormone Foundation.
News release, FDA.
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Testosterone Deficiency, Erectile Dysfunction, and ...
How Long Does Testosterone (TRT) Take To Work?
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We are frequently asked how long patients will have to wait before they start feeling better after starting testosterone replacement therapy. The best answer can get a little complicated, but there are definitely some factors that we have identified which help to predict success.
This video is a rapid fire explanation of testosterone replacement therapy (TRT). It will provide a great foundation for those seeking to learn more about Low T treatments like testosterone gels, pellets, or injections.
First of all, it is important to be looking for the right things. Knowing what the real symptoms of Low T areis extremely important.
Making sure that your treatment is medically supervised by providers who know The Side Effects of TRT well, and being consistent with the prescribed therapy, plays the biggest role in how quickly you will respond.
Keep in mind that people are not cookie cutter clones of one another either each individual is different, and your response will be too.
Understanding that there is no hard fast rule here, most patients feel significant improvement in symptoms within 4-6 weeks of starting treatment for Low T.
It is common for symptoms like low sex drive and difficulty maintaining sleep to respond sooner. On the other hand, factors like obesity, chronic illness, or medications can make ones response slower or more subtle at first.
It has been our experience that failure to respond to treatment (when the person is committed to staying consistent with appointments and recommendations) is very rare.
Especially with injections, response to therapy has nothing to do withwaiting for your testosterone levels to come up.
If properly managed, your levels can be normalized with the first dose, possibly in just a few days.
The lag in symptomatic response represents the time it takes for your body to achieve balance. Making numbers look better is one thing carefully balancing hormonal shifts and the potential side effects is where the art of medicine becomes crucial.
Below you will find some references to what the studies say on the subject, but ultimately, we have found the following to be true:
In the study titled, Timetable of effects of testosterone administration to hypogonadal men on variables of sex and mood (Jockenhovel, Minnemann, et al, The Aging Male, December 2009: 12 (4): 113-118), 40 men with testosterone levels definitively established as low were evaluated for timing of response to therapy.
Specifically, the researchers wanted to know how long it took for men to experience improvement in total numbers of erections and ejaculations, indicators of improved libido such as sexual thoughts and fantasies, and perceived sexual interest/desire and satisfaction with their sex lives.
Additionally, several psychosocial parameters were measured looking for changes such as levels of agitation, aggression, depression, listlessness (avoidance of activity), sociability, and activation.
Activation, by the way, is defined by Britannica Online Encyclopedia as the stimulation of the cerebral cortex into a state of general wakefulness, or attention.
Essentially, you can think of activation as concentration and alertness in this context.
It is important to note that this study only evaluated patients at three-week intervals, so any symptomatic change occurring before that point could not be documented. For the psychosocial effects assessed by the study, anxiety levels, aggression, and sociability all showed significant response at three weeks after the start of therapy.
The scoring for all three of these parameters continued to improve over the next 9 weeks, all plateauing around week 12.
When considering aggression, it is worth noting that when a mans testosterone level is normal, he is usually appropriately aggressive. A total lack of aggression is most often a social liability and can sometimes lead to missed opportunities, especially in the workplace.
On the other hand, roid rage, which is frequently associated with anabolic steroid abuse (and the supraphysiologic levels that ensue), occurs in the setting of extremely elevated levels of testosterone.
This is not something seen when TRT is managed responsibly and safely. The goal should always be to improve symptoms while improving testosterone levels from deficient levels to normal ones.
Depression and listlessness both decreased substantially by week 6 and remained fairly steady thereafter. For agitation and activation, both of these measurements showed sharp improvements at 9 weeks and stayed relatively stable thereafter.
This study evaluated sexual function by tracking the number of spontaneous erections, total erections, and ejaculations reported by men. Other aspects that were quantified were frequency of sexual thoughts/fantasy, intensity of sexual desire, and overall satisfaction with sex life.
For the three measurements of sexual function, men reported positive changes for all at their 3-week evaluation. The number of spontaneous and total erections, as well as the number of ejaculations, increased to stable levels between weeks 12 to 21.
Sexual thoughts and fantasy rose considerably by week three and remained at levels approximately double initial scores thereafter. Sexual desire followed a similar track, reaching a plateau around the 9th week.
Finally, satisfaction with sex life rose sharply by 3rd week and continued on a dramatic rise through week-30 when the study concluded.
As the study says, Treatment of hypogonadal men (men with Low T) with testosterone is rewarding, for the patients as well as the physician.
The patient experiences, to his satisfaction, profound changes in his physical appearance and his mental make-up.
The attending physician observes the changes the patient undergoes and rarely fails to be fascinated by the multitude of functions testosterone appears to have in [the] process of masculinization in the broadest sense. The take home points are these.
The researchers behind this journal article looked only at sexual functioning and mood. There is often much more that is negatively impacted by Low T.
If you have questions or comments please take the time to contact us, we would be happy to sit down with you and discuss how testosterone replacement therapy can improve your quality of life.
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How Long Does Testosterone (TRT) Take To Work?
Testosterone(androgen) – WebMD
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Test Overview
A testosterone test checks the level of this male hormone (androgen) in the blood. Testosterone affects sexual features and development. In men, it is made in large amounts by the testicles . In both men and women, testosterone is made in small amounts by the adrenal glands , and in women, by the ovaries .
The pituitary gland controls the level of testosterone in the body. When the testosterone level is low, the pituitary gland releases a hormone called luteinizing hormone (LH). This hormone tells the testicles to make more testosterone.
Before puberty, the testosterone level in boys is normally low. Testosterone increases during puberty. This causes boys to develop a deeper voice, get bigger muscles, make sperm , and get facial and body hair. The level of testosterone is the highest around age 40, then gradually becomes less in older men.
In women, the ovaries account for half of the testosterone in the body. Women have a much smaller amount of testosterone in their bodies compared to men. But testosterone plays an important role throughout the body in both men and women. It affects the brain, bone and muscle mass, fat distribution, the vascular system, energy levels, genital tissues, and sexual functioning.
Most of the testosterone in the blood is bound to a protein called sex hormone binding globulin (SHBG). Testosterone that is not bound ("free" testosterone) may be checked if a man or a woman is having sexual problems. Free testosterone also may be tested for a person who has a condition that can change SHBG levels, such as hyperthyroidism or some types of kidney diseases.
Total testosterone levels vary throughout the day. They are usually highest in the morning and lowest in the evening.
A testosterone test is done to:
You do not need to do anything before you have this test. Your doctor may want you to do a morning blood test because testosterone levels are highest between 7 a.m. and 9 a.m.
The health professional taking a sample of blood will:
The blood sample is taken from a vein in your arm. An elastic band is wrapped around your upper arm. It may feel tight. You may feel nothing at all from the needle, or you may feel a quick sting or pinch.
There is very little chance of a problem from having a blood sample taken from a vein.
A testosterone test checks the level of this male hormone (androgen) in the blood.
The normal values listed here-called a reference range-are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.
Your doctor will have your test results in a few days.
Men
270-1070 ng/dL (9-38 nmol/L)
Women
15-70 ng/dL (0.52-2.4 nmol/L)
Children (depends on sex and age at puberty)
2-20 ng/dL or 0.07-0.7 nmol/L
The testosterone level for a postmenopausal woman is about half the normal level for a healthy, nonpregnant woman. And a pregnant woman will have 3 to 4 times the amount of testosterone compared to a healthy, nonpregnant woman.
Men
50-210 pg/mL (174-729 pmol/L)
Women
Reasons you may not be able to have the test or why the results may not be helpful include:
To learn more, see:
Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.
Chernecky CC, Berger BJ (2008). Laboratory Tests and Diagnostic Procedures, 5th ed. St. Louis: Saunders.
Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.
Pagana KD, Pagana TJ (2010). Mosbys Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineSpecialist Medical ReviewerAlan C. Dalkin, MD - Endocrinology
Current as ofNovember 20, 2015
WebMD Medical Reference from Healthwise
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Testosterone(androgen) - WebMD
How short-term increases in testosterone change men’s thinking style – The British Psychological Society
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In a guest post on our Research Digest blog, Emma Young looks at a new paper published in the journal Psychological Science.
Written bya team from Caltech, the University of Pennsylvania, Western University and the ZRT Laboratory in Oregon, it finds that a short-term rise in testosterone as might occur when in the presence of an attractive potential mateor during competition shifts the way men think. It encouragesthem to rely on quick, intuitive, and generally less accurate, judgements, rather than engaging in careful, more deliberate thought.
Our results demonstrate a clear and robust causal effect of testosterone on human cognition and decision making, the researchers write. The influence of testosterone on the Cognitive Reflection Test, alongside its lack of effect on the arithmetic control task, suggests that testosterone decreases the probability of engaging in slow and effortful cognitive processes but keeps the capacity to perform them intact."
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How short-term increases in testosterone change men's thinking style - The British Psychological Society
Testosterone Lawsuits Begin, Outcomes Split – LawyersandSettlements.com
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Chicago, ILThe makers of a testosterone supplement that only carries FDA approval for hypogonadism (severely depleted testosterone) but nonetheless has been heavily marketed to treat a largely manufactured disease, won their day in court at the end of last month when a jury in state court found in favor of AndroGel manufacturer AbbVie. The decision translates to a loss for the plaintiff, who alleged in his testosterone lawsuit that his heart attack was associated with his use of AndroGel.
Plaintiff James Couch became interested in advertisements for AndroGel as a response to so-called Low-T. The manufacturer claimed that depression and lethargy could be related to a drop in testosterone levels and that use of AndroGel could boost an individuals energy and foster a return to vitality. Couch alleged in his testosterone side effects lawsuit that there was no inference to the normal depletion of testosterone with age, and that use of testosterone supplements in otherwise healthy men carried a risk for testosterone heart attack.
The plaintiff went to his doctor and asked to have his testosterone levels checked out. Couch was provided with a prescription for AndroGel in February, 2013 and later that year suffered a heart attack, after which he received a defibrillator implant to help regulate his damaged heart.
Couch filed his testosterone lawsuit one of hundreds housed in state court in Illinois about six months following his heart attack, asserting that AbbVie knew about the increased risk for testosterone heart attack and testosterone stroke but withheld those risks from consumers, and declined to study the link. Couch made claims for strict liability, negligence, breach of implied warranty, negligent misrepresentation and willful and wanton conduct.
However, following a two-week trial the jury dismissed the plaintiffs claims and found in favor of the manufacturer. In their defense, AbbVie noted that Couch was seen to have refilled his prescription for AndroGel only once before he stopped using it altogether. He suffered his heart attack two months after stopping use of testosterone, according to Court documents.
Court records also showed that attorneys for the plaintiff were not allowed to present years of marketing materials which were alleged to reflect how AbbVie sought to expand the market for AndroGel.
That evidence was allowed in the first bellwether trial for AndroGel in federal court as part of multidistrict litigation. In that case, plaintiff Jess Mitchell claimed his heart attack was related to his use of AndroGel for Low-T and accused AbbVie of misrepresentation. He asserted that AbbVie claimed that testosterone replacement therapy was safe and effective, when in fact it was not.
The jury in the federal trial determined, at the end of July that use of AndroGel did not cause Mitchells heart attack and thus did not award compensatory damages. However, unlike the state trial the jury awarded $150 million in punitive damages on the misrepresentation claim.
The next federal trial in the AndroGel MDL is scheduled for this month (In re: Testosterone Replacement Therapy Products Liability Litigation, Case No.1:14-cv-01748, in the US District Court for the Northern District of Illinois). Ahead of the start of that trial and perhaps with a view to how the state trial turned out AbbVie has requested that marketing materials not be allowed as evidence in the second federal trial, as it was in the first.
The precise impact of that evidence was demonstrated in a verdict that found no compensable loss, but went on to award punitive damages that were tethered to nothing, AbbVie said of the Mitchell verdict (Mitchell et al. v. AbbVie Inc. et al., Case No.1:14-cv-09178, US District Court for the Northern District of Illinois).
As for the Couch trial, AbbVie had this to say in their motion: The impact of that ruling also is clear the trial was focused on the claims at issue and the jurys verdict was not overshadowed by an unconstitutional and collateral finding that AbbVie should be punished for conduct that had nothing to do with the plaintiff.
There are about 150 testosterone lawsuits in state court in Illinois, with the next lawsuit prepared but as yet without a start date. Couch plans to appeal the verdict in his state court trial.
The Couch testosterone lawsuit is Couch v. AbbVie Inc., Case No. 2014-L-005859, in the Circuit Court of Cook County, Illinois.
However, testosterone has never been approved for vanity use in men seeking a so-called fountain of youth and having found one in testosterone supplements. In otherwise healthy men, who may not be aware that testosterone levels ebb and flow with age and even according to the time of day, use of testosterone supplements can pose a risk to the cardiovascular system, or so it has been alleged. Research has suggested that testosterone supplements can multiply red blood cells, thickening the blood when patients are at an age when thinner blood is needed to travel through veins shrinking with age and plaque build-up. Testosterone heart attack or testosterone stroke can sometimes lead to testosterone death.
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Testosterone Lawsuits Begin, Outcomes Split - LawyersandSettlements.com
Does propecia work in owmen – How long before propecia works – Testosterone replacement therapy and propecia – Twin Cities Arts Reader
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Adam Jacobs (Aladdin) and Isabelle McCalla (Jasmine) star in the national touring production of Aladdin. Photo by Deen van Meer.How many people does it take to put on a national tour of a Broadway show? If the show isAladdin, the answer is 75...if you only count the people who show
The Catalyst Quartet rehearsing.It was the first of August. Dr. Deborah Justice was settling in for a month of fiddling around musically speaking when the email arrived. "Im afraid I have some sad news from Caracas," it began. "Venezuela at this moment is now a war zone."At that
The late J. Otis Powell.Poet, playwright, and overall multi-talented artist J. Otis Powell died on Monday, August 28. Powell was 61 years' old, and had been awarded a Sally Ordway Irvine Award for Commitment just five days prior. He had struggled with ill health, and received a kidney transplant several
A bar chart showing historical box office totals for the Minnesota Fringe Festival.The Minnesota Fringe Festival announced the final statistics today for the 2017 Minnesota Fringe Festival. The 11-day festival brought in 46,076 butts-in-seats, spread across 860 performances of 167 shows at 17 venues in Minneapolis.Why Count Butts-in-Seats?Since 2016, the
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Testosterone | You and Your Hormones from the Society for …
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Alternative names for testosterone
Testo (brand name for testosterone formulations); 4-androsten-17-ol-3-one
Testosterone is produced by the gonads (by the Leydig cells in testes in men and by the ovaries in women), although small quantities are also produced by the adrenal glands in both sexes.It is an androgen, meaning that it stimulates the development of male characteristics.
Present in much greater levels in men than women, testosterone initiates the development of the male internal and external reproductive organs during foetal development and is essential for the production of sperm in adult life.This hormone also signals the body to make new blood cells, ensures that muscles and bones stay strong during and after puberty and enhances libido both in men and women.Testosterone is linked to many of the changes seen in boys during puberty (including an increase in height, body and pubic hair growth, enlargement of the penis, testes and prostate gland, and changes in sexual and aggressive behaviour).It also regulates the secretion of luteinising hormone and follicle stimulating hormone.To effect these changes, testosterone is often converted into another androgen called dihydrotestosterone.
In women, testosterone is produced by the ovaries and adrenal glands.The majority of testosterone produced in the ovary is converted to the principle female sex hormone, oestradiol.
The regulation of testosterone production is tightly controlled to maintain normal levels in blood, although levels are usually highest in the morning and fall after that.The hypothalamus and the pituitary gland are important in controlling the amount of testosterone produced by the testes.In response to gonadotrophin-releasing hormone from the hypothalamus, the pituitary gland produces luteinising hormone which travels in the bloodstream to the gonads and stimulates the production and release of testosterone.
As blood levels of testosterone increase, this feeds back to suppress the production of gonadotrophin-releasing hormone from the hypothalamus which, in turn, suppresses production of luteinising hormone by the pituitary gland. Levels of testosterone begin to fall as a result, so negative feedback decreases and the hypothalamus resumes secretion of gonadotrophin-releasing hormone.
The effect excess testosterone has on the body depends on both age and sex. It is unlikely that adult men will develop a disorder in which they produce too much testosterone and it is often difficult to spot that an adult male has too much testosterone.More obviously, young children with too much testosterone may enter a false growth spurt and show signs of early puberty and young girls may experience abnormal changes to their genitalia. In both males and females, too much testosterone can lead to precocious puberty and result in infertility.
In women, high blood levels of testosterone may also be an indicator of polycystic ovary syndrome.Women with this condition may notice increased acne, body and facial hair (called hirsutism), balding at the front of the hairline, increased muscle bulk and a deepening voice.
There are also several conditions that cause the body to produce too much testosterone.These include androgen resistance, congenital adrenal hyperplasia and ovarian cancer.
The use of anabolic steroids (manufactured androgenic hormones) can lead to a perceived high level of testosterone by the hypothalamus, resulting in reduced luteinising hormone secretion from the pituitary gland and, in turn, a decrease in the amount of testosterone produced within the testes, while artificial testosterone levels remain high. In men, prolonged exposure to anabolic steroids results in infertility, a decreased sex drive, shrinking of the testes and breast development. Liver damage may result from its prolonged attempts to detoxify the anabolic steroids.Behavioural changes (such as increased irritability) may also be observed.Undesirable reactions also occur in women who take anabolic steroids regularly, as a high concentration of testosterone, either natural or manufactured, can cause masculinisation (virilisation) of women.
If testosterone deficiency occurs during foetal development, then masculinisation of the foetus will fail to occur normally and this may give rise to disorders of sex development. If testosterone deficiency occurs during puberty, a boys growth may slow and no growth spurt will be seen.The child may also fail to develop full sexual characteristics (hypogonadism) associated with men undergoing puberty, including development of pubic hair, growth of the penis and testes and deepening of the voice. Around the time of puberty, boys with too little testosterone may also have less than normal strength and endurance, and their arms and legs may continue to grow out of proportion with the rest of their body.
In adult men, low testosterone may lead to a reduction in muscle bulk, loss of body hair and a wrinkled parchment-like appearance of the skin. Testosterone levels in men decline naturally as they age. In the media, this is sometimes referred to as the male menopause (andropause).
Low testosterone levels can cause mood disturbances, increased body fat, loss of muscle tone, inadequate erections and poor sexual performance, osteoporosis, difficulty with concentration, memory loss and sleep difficulties. Current research suggests that this effect occurs in only a small group of ageing men.However, there is a lot of research currently in progress to find out more about the effects of testosterone in older men and also whether the use of testosterone replacement therapy would have any benefits.
Last reviewed: Jan 2015
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Viagra testosterone mail order – Viagra prescription cost 2016 – Magnetic Media (press release)
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Testosterone replacement therapy associated with improved urinary, sexual function – ProHealth
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Reprinted with the kind permission of Life Extension.
August 23 2017.An article appearing on July 18, 2017 in theJournal of Urologydocuments improvements in sexual function, urinary function and quality of life among men who receivedtestosterone replacement therapy.
The prospective registry study involved 656 men with low testosterone levels and symptoms of testosterone deficiency, among whom 360 were regularly treated with parenteral testosterone undecanoate for up to 10 years. The remainder of the subjects, who chose not to be treated with testosterone, received biannual routine clinic visits.
The researchers, from Boston University School of Medicine and School of Public Health in collaboration with German urologists, found that men who received testosterone therapy experienced significant decreases in their International Prostate Symptom Score, post-voiding bladder volume and Aging Males Symptoms scale, which assesses health-related quality of life. The percentage of patients without erectile dysfunction significantly improved in the testosterone treated group, from 17.1% at the beginning of the study, to 74.4% of the study at the last visit. In contrast, subjects who did not receive the hormone experienced deterioration in erectile function as well as in voiding functions. Prostate specific antigen (PSA), a marker which, when elevated, is associated with an increased risk of prostate cancer, remained unchanged in both groups over the course of the study.
While there were five deaths, 8 nonfatal strokes and 8 nonfatal heart attacks over the 8-month median follow-up period in the untreated group, none of these events occurred among those who received testosterone.
Long-term testosterone therapy, in men with testosterone deficiency, was well tolerated with excellent adherence suggesting a high level of patient satisfaction, authors Karim Sultan Haider and colleagues conclude. A progressive and sustained improvement in urinary and sexual function was recorded in men receiving long-term testosterone therapy, contributing to overall improvement in quality of life.
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Testosterone replacement therapy associated with improved urinary, sexual function - ProHealth