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New research suggests that there could be health hazards associated with consuming excessive amounts of beta-carotene .

This antioxidant is a naturally occurring pigment that gives color to foods such as carrots, sweet potatoes and certain greens. It also converts to vitamin A, and foods and supplements are the only sources for this essential nutrient.

But scientists at Ohio State University have found that certain molecules that derive from beta-carotene have an opposite effect in the body: They actually block some actions of vitamin A, which is critical to human vision, bone and skin health, metabolism and immune function.

Because these molecules derive from beta-carotene, researchers predict that a large amount of this antioxidant is accompanied by a larger amount of these anti-vitamin-A molecules, as well.

Vitamin A provides its health benefits by activating hundreds of genes. This means that if compounds contained in a typical source of the vitamin are actually lowering its activity instead of promoting its benefits, too much beta-carotene could paradoxically result in too little vitamin A.

The findings also might explain why, in a decades-old clinical trial, more people who were heavily supplemented with beta-carotene ended up with lung cancer than did research participants who took no beta-carotene at all. The trial was ended early because of that unexpected outcome.

The scientists arent recommending against eating foods high in beta-carotene, and they are continuing their studies to determine what environmental and biological conditions are most likely to lead to these molecules production.

We determined that these compounds are in foods, theyre present under normal circumstances, and theyre pretty routinely found in blood in humans, and therefore they may represent a dark side of beta-carotene, said Earl Harrison, Deans Distinguished Professor of Human Nutrition at Ohio State and lead author of the study. These materials definitely have anti-vitamin-A properties, and they could basically disrupt or at least affect the whole body metabolism and action of vitamin A. But we have to study them further to know for sure.

The study is scheduled for publication in the May 4, 2012, issue of the Journal of Biological Chemistry.

Previous research has already established that when beta-carotene is metabolized, it is broken in half by an enzyme, which produces two vitamin A molecules.

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Potential Dark Side To Diets High In Beta-Carotene

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Home » Diets that Work » Potential Dark Side To Diets High In Beta-Carotene