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Home » Uncategorized » Scientists document first cases of acquired Alzheimer’s due to decades-old childhood treatment – ZME Science

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Alzheimers disease, a devastating neurological condition affecting people in late adulthood, may have been acquired by five individuals through medical treatments received decades ago. This marks the first instance of Alzheimers in living patients potentially linked to medical procedures.

The individuals in question were treated as children with cadaver-derived human growth hormone (c-hGH), extracted from the pituitary glands of deceased donors. This treatment was administered to at least 1,848 people in the UK between 1959 and 1985 for various forms of short stature. The practice was discontinued in 1985 after it was discovered that some batches of c-hGH were contaminated with infectious proteins called prions, responsible for Creutzfeldt-Jakob disease (CJD) in some patients. Fortunately, this medication was replaced a long time ago by synthetic growth hormone, which is free from the risk of transmitting CJD.

The same researchers previously found that some patients with CJD due to c-hGH treatment had also developed deposits of amyloid-beta protein in their brains prematurely. Further research in 2018 revealed that archived samples of c-hGH were contaminated with amyloid-beta protein. When injected into laboratory mice, these samples transmitted amyloid-beta pathology, suggesting that long-term survivors of c-hGH treatment might develop Alzheimers disease.

Amyloid-beta, a fragment produced from a larger precursor protein, is now considered a hallmark of Alzheimers. Patients with this condition have unusually high quantities of amyloid-beta in their brains.

In a healthy brain, amyloid-beta plays various roles, including regulating neural activity and supporting brain health. However, in Alzheimers disease, something goes awry. The protein begins to accumulate, forming clumps and eventually dense, insoluble plaques that disrupt brain function. This process is believed to be a critical factor in the onset and progression of Alzheimers, but the exact reasons why and how this accumulation occurs remain one of the great mysteries of modern neuroscience.

The new study focuses on eight individuals who received c-hGH treatment in childhood. The patients were admitted to the University College Londons National Prion Clinic at the National Hospital for Neurology and Neurosurgery. Among them, five displayed dementia symptoms consistent with Alzheimers disease or met the diagnostic criteria for it.

What is striking is their age range: 38 to 55 years when symptoms appeared, far younger than the typical onset age for sporadic Alzheimers in the mid-60s or later. Genetic testing ruled out inherited Alzheimers in these patients.

The c-hGH treatment is now obsolete, so there is no risk of new transmissions via this route. The authors of the study emphasize that the circumstances of these Alzheimers cases are highly unusual and that the disease cannot be spread through daily contact. There is no way you can get Alzheimers through close contact or routine care of a patient that was never a remote possibility.

However, now that this old treatment has been strongly linked to acquired Alzheimers, one can only wonder if other treatments, discontinued or otherwise, may also be responsible for Alzheimers.

The recognition of transmission of amyloid-beta pathology in these rare situations should lead us to review measures to prevent accidental transmission via other medical or surgical procedures, to prevent such cases from occurring in the future, said lead author Professor John Collinge, Director of the UCL Institute of Prion Diseases.

Importantly, our findings also suggest that Alzheimers and some other neurological conditions share similar disease processes to CJD, and this may have important implications for understanding and treating Alzheimers disease in the future.

The findings appeared in the journal Nature Medicine.

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Scientists document first cases of acquired Alzheimer's due to decades-old childhood treatment - ZME Science

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Home » Uncategorized » Scientists document first cases of acquired Alzheimer’s due to decades-old childhood treatment – ZME Science