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With each day that goes by, we keep hearing of novel coronavirus therapies that can speed up recovery time and potentially reduce the risk of complications and death. It seems like doctors are throwing everything at the disease to see what sticks, but thats not exactly the case. Theyve simply had time to observe that some of the drugs that were created for other ailments can help COVID-19 patients as well. One such example is remdesivir, which was developed for Ebola but never used to treat it. Then theres the controversial hydroxychloroquine, a decades-old anti-malarial that can help some COVID-19 patients, but its not as effective and safe as people would have hoped. Anti-viral favipiravir (Avigan) was made for influenza but it might work on COVID-19 as well. And if this new study is right, a treatment thats usually given to prostate cancer patients could be used to protect men from the novel coronavirus.

Cancer is the kind of preexisting medical condition that might worsen the impact of the COVID-19 disease on patients. With that in mind, its not surprising that doctors paid close attention to their cohorts of cancer patients who were infected with the new virus. Researchers from Switzerland and Italy penned a new study that shows androgen-deprivation therapy (ADT) for prostate cancer would actually protect men from the novel coronavirus infection.

Published in the leading cancer journal Annals of Oncology, the study details this startling discovery. Researchers found that patients receiving ADT drugs were less likely to develop COVID-19, and the disease was less severe following an infection. The study says that out of 4,532 men in the Veneto region of Italy, 430 had cancer, with 118 of them having prostate cancer. Men with cancer had a 1.8x higher risk of COVID-19 infection compared to the male population without the ailment, and they developed a more severe form of the disease, the report says.

But when they looked at the entire population of prostate cancer patients in the Veneto region, they found that only four men out of 5,273 patients on ADT were infected with the novel coronavirus, and none of them died. Thats the kind of unusual statistical discrepancy that warrants more research.

37,161 men who have the same kind of cancer were treated with other therapies. Of those, 114 got COVID-19 and 18 died. Of the 79,661 patients with other types of cancer, 312 were infected, and 57 died.

The researchers now believe that men who do not have prostate cancer can be treated with ADT to either prevent COVID-19 symptoms or reduce the severity of the disease after infection.

I hope that our findings inspire other clinicians to carry out clinical trials using transient ADT in men infected with COVID-19, in addition to other experimental therapies, Swiss Universit della Svizzera Italiana professor Andrea Alimonti said. Although these data need to be further validated in additional large cohorts of patients with COVID-19, they provide an answer to the hypothesis that androgen levels can facilitate coronavirus infections and increase the severity of symptoms, as has been seen in male patients.

The Swiss and Italian researchers were motivated to look into this potential therapy following recent research that said a protein called TMPRSS2 from the family of Type II Transmembrane Serine Proteases could help the virus infect human cells. TMPRSS2 can be found in other places such as the lungs, which is where the novel coronavirus replicates the most, with potentially fatal consequences.

ADT drugs target androgen receptors, which regulate the high levels of TMPRSS2 in the prostate. Therefore, ADT can also regulate TMPRSS2 levels in the lungs and potentially reduce the viruss capability to infect cells. The ADT therapy would not last longer than a month and should have no significant side effects, Alimonti said. For instance, luteinizing hormone-releasing hormone, or LH-RH, antagonists can decrease the levels of testosterone in patients in 48 hours, and the effect of this therapy is transient. Once a patient stops taking the drug, his testosterone levels go back to the previous levels.

As with other coronavirus research, the cancer study will require additional research to see whether ADT drugs in COVID-19 patients who dont have cancer actually works. But the research doesnt only offer a potential treatment for men, it also explains why men might develop worse COVID-19 forms.

This could explain why men infected by COVID-19 develop a more aggressive form of disease than women, Alimonti said. It is known that ADT can decrease the levels of TMPRSS2 in prostate cancer patients, and some experimental evidence demonstrates that this could happen not only in the prostate but also in other tissues. So I wanted to see if ADT could decrease the risk of developing coronavirus infection in men with prostate cancer.

That may not be the sole explanation, as other studies show the virus does affect the testes directly. A recent study suggested that ACE2 receptors in the testicles explain why men are more likely than women to develop severe cases of COVID-19. Another report even showed that the virus can be present in semen, suggesting that sexual transmission could be a theoretical risk.

Image Source: Peter Foley/EPA-EFE/Shutterstock

Chris Smith started writing about gadgets as a hobby, and before he knew it he was sharing his views on tech stuff with readers around the world. Whenever he's not writing about gadgets he miserably fails to stay away from them, although he desperately tries. But that's not necessarily a bad thing.

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This startling discovery might protect men from coronavirus - BGR

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Many natural medicines used by humanity over time are not recognized in actual days, supplements like Tribulus Terrestris, Maca Peruana, and Melatonin are very useful to provide a better lifestyle.Those supplements are natural and can improve sexual functions, metabolism, cognition, and response from the body to external conditions.

Some of those supplements were used by civilizations thousand years ago, in fact, when these herbs were used wasnt in supplement way, it was direct as plant most of the time in raw or crude ways

Here a list for you with some of those supplements that can help improve your body functions and make you live happier.

1 Peruvian Maca

This root was first used by people of Andes and was recognized worldwide by its functions related to sexual improvement from men and women, it can help women relieve symptoms of menopause and improve metabolism helping burn more fat during the day.

2 Tribulus Terrestris

Its another plant that is fully used flowers and leaves to improve libido, but it works in a different way, libido increased felling come from testosterone that is stimulated by Tribulus Terrestris, the metabolism get increased when levels of testosterone get normal. Fixing normal levels of testosterone many other benefits can be felt.

3 Melatonin

4 DHEA

DHEA is a hormone produced by the body thats responsible for many other hormones production that plays important functions on the body, hormones like testosterone get balanced when DHEA production is regulated after 30 DHEA levels get decreased and functions like muscle development get harder many other benefits come from hormonal balance, taking DHEA its a good way to fix all other hormone levels that was decreased by aging.

5 Lemon Essential Oil

6 Omega 3

Omega 3 provides many benefits, it plays important roles in the brain and can prevent many diseases like Alzheimer's, its recognized by an anti-inflammatory answer and can prevent most inflammatory diseases like cancer. It can be used to increase metabolism by decreasing fat resistance making it easier to be burned and protect the heart against bad fat.

7 Glucosamine and Chondroitin

Those 2 nutrients are fundamental to maintain the good health of joints, mainly when we get aged and need be on move, its hard to balance moves with joint resistance thats acquired over the time, glucosamine and chondroitin can help joint get lubricated and reduce pains.

8 Green Tea

Thats a very good antioxidant and as it is can be used to increase the immune system, in addition, it can also be used as a stimulant. Its caffeine content may help fat loss and some of the studies point it as a good joint protector.

9 Multivitamins

Its always hard to eat all foods that provide all vitamins and minerals spectrum, that way some of the supplements can be taken to provide all needings of your body, those supplements are not expensive and can make the bodywork better and improve metabolism during the day. Its not recommended to take it at night because probably it will make you go to the restroom.

10 BCAA ( Amino acids )

Amino acids are very important for muscle growth and to prevent it catabolism, in addition, it can also be used to increase the immune system. BCAA is showing very good effects on liver detox and restoring and can reduce fatigue from exercises.

That was our list of 10 best supplements that can help improve your life, any supplement can replace healthy habits, take care of your food, do exercises, drink water, breathe pure air, and use supplements wisely.

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Top 10 supplements that should be used for men and women - The Jerusalem Post

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The global Androgen Replacement Therapy Market research report thoroughly explains each and every aspect related to the Androgen Replacement Therapy Market, which facilitates the reports reader to study and evaluate the upcoming market trend and execute the analytical data to promote the business. The growth trend forecasted on account of thorough examination offers in-depth information regarding the global Androgen Replacement Therapy Market. A pathway of development is offered by the market to the several connected networks of businesses under it, which include different firms, industries, organizations, vendors, distributors, and local manufacturers too. All the key Androgen Replacement Therapy Market players compete with each other by offering better products and services at a reasonable price in order to grab significant share at the regional and global level market.

Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy, in which androgens, often testosterone, are replaced. ART is often prescribed to counter the effects of male hypogonadism. It typically involves the administration of testosterone through injections, skin creams, patches, gels, or subcutaneous pellets. Testosterone replacement therapy is a promising technology for improving symptoms of hypogonadism and to raise the testosterone level. Furthermore, benefits related to application of testosterone replacement therapy include an increase in muscle tissue, overall surge in energy, and significant decrease in depression symptoms.

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This report sample includesBrief Introduction to the research report.Table of Contents (Scope covered as a part of the study)Top players in the marketResearch framework (presentation)Research methodology adopted by Coherent Market Insights

The report incorporates an estimated impact of strict standards and regulations set by the government over the market in the upcoming years. The market report also comprises exhaustive research done using several analytical tools such as SWOT analysis to identify the market growth pattern.

Top Manufacturers in GlobalAndrogen Replacement TherapyMarket Includes:AbbVie, Inc., Allergan Plc, Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International Plc, Mylan N.V., Novartis International AG, Pfizer, Inc., Clarus Therapeutics, Ferring Holding SA, Perrigo Company Plc, Acerus Pharmaceuticals Corporation, Upsher-Smith Laboratories, LLC, Dr. Reddys Laboratories, Bausch Health Companies Inc., Sun Pharmaceutical Industries Ltd., and Par Pharmaceutical.

Regions & Countries Mentioned In The Androgen Replacement Therapy Market Report:

Key Highlights of the Table of Contents:

Androgen Replacement Therapy Market Study Coverage: It includes key manufacturers covered, key market segments, the scope of products offered in the global market, years considered, and study objectives. Furthermore, it tuches the segmentation study provided in the report on the basis of the type of product and applications.

Androgen Replacement Therapy Market Executive Summary: This section emphasizes on the key studies, market growth rate,Competitive landscape, market drivers, trends, and issues.

Androgen Replacement Therapy Market Production by Region: The report provides information related to import and export, production, revenue, and key players of all regional markets studied are covered in this section.

Androgen Replacement Therapy Market Profile of Manufacturers: Analysis of each market player profiled is detailed in this section. This also provides SWOT analysis, products, production, value, capacity, and other vital factors of the individual player.

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Report Overview:It includes the Androgen Replacement Therapy market study scope, players covered, key market segments, market analysis by application, market analysis by type, and other chapters that give an overview of the research study.

Executive Summary:This section of the report gives information about Androgen Replacement Therapy market trends and shares, market size analysis by region and analysis of global market size. Under market size analysis by region, analysis of market share and growth rate by region is provided.

Profiles of International Players:Here, key players of the Androgen Replacement Therapy market are studied on the basis of gross margin, price, revenue, corporate sales, and production. This section gives a business overview of the players and shares their important company details.

Regional Study:All of the regions and countries analyzed in the Androgen Replacement Therapy market report is studied on the basis of market size by application, the market size by product, key players, and market forecast.

An Overview of the Impact of COVID-19 on this Market:

The pandemic of COVID-19 continues to expand and impact over 175 countries and territories. Although the outbreak appears to have slowed in China, COVID-19 has impacted globally. The pandemic could affect three main aspects of the global economy: production, supply chain, and firms and financial markets. National governments have announced largely uncoordinated, country-specific responses to the virus. As authorities encourage social distancing and consumers stay indoors, several businesses are hit. However, coherent, coordinated, and credible policy responses are expected to offer the best chance at limiting the economic fallout.

National governments and international bodies are focused on adopting collaborative efforts to encourage financial institutions to meet the financial needs of customers and members affected by the coronavirus. However, there are some sectors that have remained unscathed from the impact of the pandemic and there are some that are hit the hardest.

We, at Coherent Market Insights, understand the economic impact on various sectors and markets. Using our holistic market research methodology, we are focused on aiding your business sustain and grow during COVID-19 pandemics. With deep expertise across various industries-no matter how large or small- and with a team of highly experienced and dedicated analysts, Coherent Market Insights will offer you an impact analysis of coronavirus outbreak across industries to help you prepare for the future.

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Androgen Replacement Therapy Market 2020 Coronavirus (Covid-19) Business Impact Future Forecast Assessed On The Basis Of How The Market Is Predicted...

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If youve suffered from hormonal acne, you know there's no easy fix. And yet, there's a supplement that's starting to garner attention for how well it seems to work. Diindolylmethane, or DIM, is a compound derived from cruciferous vegetables (think: broccoli, cauliflower, brussels sprouts, etc.)but if you cant get enough of it through your diet, it also comes in supplement form.

While it might seem too good to be true that a compound from green veggies could heal hormonal acne, some research indicates that it could even work as well as prescription medications. In fact, Morgan Rabach, MD, dermatologist and Co-Founder of LM Medical in NYC, says that it may work similarly to Spironolactone, a prescription drug dermatologists often recommend to treat hormonal acne.

Experts hypothesize that DIM may help balance hormones by blocking excess testosteroneand when hormones are balanced, hormonal breakouts should, in theory, be diminished. Lets back up a bit: When androgens (aka male hormones like testosterone) and hormone receptors (cells that translate messages to the body) bind together, it causes changes in the skin that can lead to acne.

Think of androgens binding to hormone receptors like a key in a lockthere is a cascade of effects that it unlocks when it happens, says Dr. Rabach. "This includes things like increased oil production in the face, which clogs the pores and leads to acne. In short, when androgens and hormone receptors interact, acne happens, but Spironolactone prevents that from ever happening to begin with.

DIM, as mentioned before, is thought to have the same mechanism as spironolactone. It binds to the androgen receptor so that there's no 'hole' for the androgen 'keys' to bind to," says Dr. Rabach. "When the the two cant bind, then oil isnt increased, and fewer clogged pores means less acne."

Because there is not yet solid data backing up these results or documenting clear dosages to recommend, Dr. Rabach says she's unlikely to recommend DIM in spite of the fact that, anecdotally, it works for many people.

"DIM shows promising results on hormonal acne in some people and may be a viable natural alternative for people that do not want traditional medicine, but there are no randomized placebo controlled studies, so I can't endorse it 100 percent," she says.

One other thing to note: The supplement industry isn't regulated, meaning the FDA doesn't vet products to make sure they contain exactly what they say they do. So, even if research indicated the dosage required for results (which it doesn't), it's hard to say for sure if you'd actually be getting that dosage from supplements you can buy in stores.

New York City-based publicist and blogger Stephanie OQuigley read about DIM online after finding herself lost for options on treating acne. Because it appeared every month at the same time and was mostly centered around her chin, Stephanie strongly suspected it was related to hormonesand no amount of clean pillowcases, salicylic acid or a dairy-free diet, was making a difference.

I started taking 200mg of DIMI'd read online that this was a great starting dose," she says. "After two to three months, I started to see results." After four months, her skin was pretty much clear. I didnt have to worry about waking up with a big whitehead on my chin," she says. "I would get the odd pimple, but for the most part, I felt great about my complexion.

For Stephanie, however, the good results ceased after seven months. There are so many factors that we dont know about each individual who takes DIM, like how is their diet, skin hygiene, stress, etc.," says Dr. Rabach. "One of those factors or a combination can override DIM." Unfortunately, it comes back to the same limitations on our knowledge of DIM's effectiveness and how it works: "There is no good research to explain how long or if DIM will work for everyone in a predictable way," says Dr. Rabach."

While there is no research-backed recommended dosage, anecdotally, some people say taking 100 milligrams twice a day has worked for themthough, of course, you should always consult your dermatologist or doctor before adding a new supplement to your regimen.

If you and your doctor do decide DIM is a good fit for you, Dr. Rabach says the most common side effects to be aware of are nausea, vomiting, bloating, diarrhea, gas, and headaches. It could also darken your urine due to the presence of DIM metabolites that have an amber color. "Individuals who eat large amounts of DIM-containing cruciferous vegetables would notice similarly colored urine," says naturopathic doctor Marcus Laux.

Bottom line: It may be worth a shotif your doctor approves.

While the hard-and-fast data and studies may not be there for DIM, the initial feedback from people who have used it is that it may work very similarly to Spironolactone. Plus, there are multiple personal success stories online. Sound like it might be a good fit for you? Be sure to have a conversation with your doctor first to determine whether it's safe.

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How DIM Supplements Work On Hormonal Acne, According To A Derm - Women's Health

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Grammy-winning singer Adele has been shocking fans all year with her weight loss transformation. Back in January, the singer caused a stir after photos emerged of her looking slimmer both at Drakes costume party and on vacation with Harry Styles.

These pictures had some fans congratulating her and others concerned for her health. At the time, an inside source claimed that Adele was happy and was trying to become healthier for her son. So where is Adele on her weight loss journey now, and is she losing weight just to be skinny?

On Wednesday, May 6, Adele took to Instagram for her 32nd birthday to post the first photo shed posted since the holidays. Thank you for the birthday love. I hope youre all staying safe and sane during this crazy time. she writes, while also thanking first responders and health workers.

To go along with the sweet message is a picture of her new figure; the singer seems to have lost much more weight since the beginning of the year. A medical expert recently told Us Weekly that she estimated that Adele has lost about 150 pounds in total.

Fans and friends alike were shocked and delighted, and the photo has garnered over 10 million likes. THATS MY GIRLLLLL, gushes actor and comedian Rickey Thompson. Instagram model Olivia Pierson tells Adele in her comment that shes stunning.

However, many others were not so positive. You were more beautiful before, sorry. one fan comments.

So ummm what happened to I make music for ears not eyes boo? accuses another.

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As Adeles former London-based personal trainer, its disheartening to read negative commentary and fat-phobic accusations questioning the genuineness of her amazing weight loss. In my personal experience of working with her through many highs and lows, she always marched to the beat of her own drum on her own terms. She never undermined her God-given talent in any way. She let her incredible voice do the talking, or should I say singing! She never once pretended to be something that she wasnt. What you saw was what you got. And we all LOVED it! When Adele and I started our journey together, it was never about getting super skinny. It was about getting her healthy. Especially post pregnancy and post surgery. When 25 dropped and the tour announced, we had to get ready for a 13 month gruelling schedule. In that time, she warmed to training and made better food choices. As a result, she lost considerable weight and people took notice. Her body transformation was splashed across every media outlet. The attention it generated was mind-blowing. Since she moved to LA, its been well documented that she underwent some tough personal changes. Its only natural that with change comes a new sense of self and wanting to be your best possible version. She embraced better eating habits and committed to her fitness and is sweating! I could not be prouder or happier for her! This metamorphosis is not for album sales, publicity or to be a role model. She is doing it for herself and for Angelo. My hope is that people appreciate the hard work that Adele has done to improve herself for the benefit to her and her family only. She did not lose the weight to make others feel bad about themselves. This personal transformation has nothing to do with me or you. Its about Adele and how she wants to live her life. She has not changed from the Adele we grew up with and have loved. There is just a little less of her to go around. #adele #fabulous #strong #songbird #transformation #powerful #voice #love #rumorhasit #pt

A post shared by Pete Geracimo (@petegeracimo) on May 7, 2020 at 10:14am PDT

After that Instagram post went viral, Adeles personal trainer, Pete Geracimo, opened up in an Instagram caption about Adeles weight loss journey and what its meant to her. Geracimo acknowledges that its been disheartening to see negative comments and fat-phobic accusations about the singers weight loss and her motivations.

When Adele and I started our journey together, it was never about getting super skinny. It was about getting her healthy. Especially post pregnancy and post surgery, he clarifies for everyone wondering if Adele lost weight just for vanity.

Geracimo further clarifies that a lot of Adeles motivation to exercise came from having to maintain stamina for her 13-month gruelling tour schedule for her album 25.

In that time, she warmed to training and made better food choices. As a result, she lost considerable weight and people took notice, he states.

It appears that, despite what her critics say, Adele is losing weight as a result of a healthy lifestyle, not simply to be skinny. As for her motivation, he said: This metamorphosis is not for album sales, publicity or to be a role model. She is doing it for herself and for [her son] Angelo.

Long before her weight loss journey began, Adele had reached incredible success in the music world. Through her years making music, she has made Grammy history by being one of only two artists (the other being Christopher Cross) to win all four General Field awards, which are Record of the Year, Album of the Year, Song of the Year, and Best New Artist.

On top of being one of only two artists to have achieved this feat, she is the first female artist to ever do so. At the time, her song Hello had the most downloads within a single week since the digital era began.

All of Adeles career highs happened before she revealed her new svelte figure, so it seems clear that her motivation to lose weight is not rooted in feeling that she needs to be skinny to be successful. No matter what the haters say, the sources close to her have consistently stated that she wants to lose weight for her health and not for her appearance.

In the end, her body is her business. The songstress once famously said: I dont make music for eyes, I make music for ears. That statement is still valid. While her body may have changed, her music is still for fans ears and not their eyes.

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Why Did Adele Lose Weight? British Singer's Motivation Is Not What Most Fans Think - Showbiz Cheat Sheet

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An American study has discovered the link between a sense of smell and the rolls under ones chin. In fact, the better it smells, the fewer calories we burn.

We all have that friend, that one friend who tells you about how just the smell of food makes them put on weight, before they dig into their kale packed quinoa super salad. Much as it may hurt you to strain a disingenuous laugh at your fitness-savvy friend, there may actually be some truth to their done to death office room joking.

Researchers at the University of California Berkeley have found that obese mice who have lost their sense of smell do in fact lose weight.

Surely thats because without their ability to sniff out their delicious fatty food which one can only assume is some kind of deep-fried cheese, and not the local RatDonalds, or similar rodent-based fast-food chain bulkier mice lose any desire to eat their problems away, right?

Interestingly enough, thats not exactly right.

These nostril-y lacking mice ate just as much fatty food as their normally smelling peers, yet only the mice that retained their sense of smell gained any weight. Whats more, mice that were given a boosted sense of smell perhaps the most useless superpower one could ever hope for grew even fatter on the same high-fat diet than ordinarily nosed mice.

This suggests that the odour of our food has great importance in how our bodies deal with calories. If you were to lose your ability to smell your food, much like our rodent friends above, your body may burn it, rather than store it.

The results of this study show a key connection between the olfactory (or smell) system and regions of the brain that regulates metabolism, particularly the hypothalamus.

It should be noted, however, that the neural circuits involved are still unknown.

Cline Riera, a former UC Berkeley postdoctoral fellow now at Los Angeles Cedars-Sinai Medical Centre, described the study as one of the first that demonstrates how we can actually alter how the brain perceives energy balance, and how the brain regulates energy balance, by manipulating olfactory inputs our noses.

Indeed, humans who lose their sense of smell because of age, injury or diseases such as Parkinsons often become anorexic, but until this point, the cause has been unclear. This is because loss of pleasure in eating also leads to depression, which in itself can cause a loss of appetite.

This study, published in this weeks Cell Metabolism journal, indicates the loss of smell itself plays a role, and suggests possible interventions for both those who have lost their sense of smell as well as those having trouble losing weight.Sensory systems play a role in metabolism, explains senior author Andrew Dillin, the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research, professor of molecular and cell biology and Howard Hughes Medical Institute Investigator.

Weight gain isnt purely a measure of the calories taken in; its also related to how those calories are perceived.

If we can validate this in humans, perhaps we can actually make a drug that doesnt interfere with smell but still blocks that metabolic circuitry. That would be amazing.

Riera notes that mice, like humans, are more sensitive to smells when they are hungry than after they have eaten, and that as a result, it is possible that the lack of smell tricks the body into thinking it has already eaten. While we search for food, our bodies store calories in case it is unsuccessful. Once food has been successfully found, however, our bodies feel free to burn those calories away.

In order to avoid condemning their furry friends to a scent free life, researchers made use of gene therapy to destroy olfactory neutrons in the mices noses, while sparing their stem cells.

This meant the mice would only lose their sense of smell for about three weeks, before the olfactory neutrons regret. The mice turned their beige fat cells the subcutaneous fat storage cells that accumulate around our thighs and midriffs into brown fat cells, which burn fatty acids to produce heat.

In fact, some turned almost all of their beige fat into brown fat, making them as lean as any of your workplace gym junkies.

White fat cells the storage cells that cluster around our internal organs and are associated with poor health outcomes also shrank in size.

The formerly chunky mice, which had also developed glucose intolerance a condition that leads to diabetes also regained normal glucose tolerance, in addition to their weight loss.

Its not all good news, though. The loss in smell was accompanied by a large increase in levels of the hormone noradrenaline: a stress response tied to the sympathetic nervous system.

In humans, this sustained hormone rise could lead to a heart attack.

As Dillin notes, though eliminating smell in humans wanting to lose weight would be a drastic step to take, it could be a viable alternative for morbidly obese people contemplating stomach stapling or bariatric surgery, even in spite of the increase noradrenaline line.

For that small group of people, you could wipe out their smell for maybe six months and then let the olfactory neutrons grow back, after theyve got their metabolic program reworked.

Dillon and Riera developed two different techniques in blocking the sense of smell in adult mice one involving genetically engineering mice to express a diphtheria receptor in their olfactory neutrons, which reach from the noses odour receptors to the olfactory centre in the brain.

When diphtheria toxin was sprayed into their nose, the neurons died, rendering the mouse smell-free until their stem cells regenerated them.

In method two, they engineered a benign virus to carry the receptor into olfactory cells only via inhalation. Once inhaled, the diphtheria toxin would again take down their sense of smells for around three weeks.Regardless of how the mouse lost their sense of smell, they ate the same amount of high-fat food as their scent appreciative cousins.

However, while the smell-deficient mice gained at most 10 per cent more weight going from 25-30 grams to 33 grams the stock standard mice gained about 100 per cent of their normal weight, climbing up to 60 grams and giving up any hope of a summer beach bod.

The smell-free mice retained a normal insulin sensitivity and response to glucose both of which are disrupted in metabolic disorders like obesity.

Better still, mice that were already chunky lost weight after their smell was knocked out, slimming down to the size of normal mice while still eating their high-fat diet. Only fat weight was lost, with no impact on muscle, organ or bone mass.

The UC Berkeley researchers then teamed up with colleagues in Germany who had developed a super smelling strain of mice, complete with more acute olfactory nerves, where they made the discovery of their increase in weight gain.

People with eating disorders sometimes have a hard time controlling how much food they are eating and they have a lot of cravings, explained Riera.

We think olfactory neurons are very important for controlling pleasure of food, and if we have a way to modulate this pathway, we might be able to block cravings in these people and help them with managing their food intake.

Of course, before you go rushing to your shed in hopes of removing your bothersome nose, it should be noted that research is still ongoing, and that mice are, believe it or not, not identical to your average human being.

Still, if all it takes to meet your shredding goals is a few weeks without your overrated sense of smell, it might be time to cancel that gym membership.

Again.

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Study: Want to lose weight? Get rid of that pesky nose - The Big Smoke Australia

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Want to know Japanese hack for weight loss? Try this black soybean tea aka Kuromame tea. Read on to know more.

The number of obese people are increasing at an alarming rate. Due to sedentary life, we hardly can focus on healthy diet as well as physical activities. We know that these two are most important factors to lose weight, however, one can also rely on some hacks which come handy to shed a few pounds. Calorie deficit, intermittent and eating patterns, diet fads such as Keto are some hacks we already know. Today we are talking about a lesser-known Japanese tea which can help to promote weight loss.

Health enthusiasts must be aware of the green tea boom in Japan and how it later spread to many nations including India. However, aside from green tea, Japan has one more tea for weight loss and better health. It is prepared not from leaves but from black soybeans. As per an article published in the Journal Of Obesity, these black soybeans can treat obesity.

Black soybean, which is also known Crown Prince of Beans, contains an antioxidant called anthocyanin. As per the Journal of Medicinal Food, anthocyanin is found to limit fat absorption by increasing lipid metabolism. Being rich in fiber, the bean tea works as an appetite controller. And fewer calories means fewer fats.

This is not all, the presence of isoflavones and saponin aid to increase the rate of metabolism. And better metabolism means fat is burned faster and weight loss goal becomes easier to achieve.

Other health benefits

The polyphenol content in the soybeans work as anti-aging agents and the same helps us to look young and fresh. The concoction apparently decreases blood pressure among his hypertension patients and also lowers blood-sugar levels among his diabetic patients. It also works as a hormone regulator, decreases the chances of various heart diseases, lowers cholesterol, and reducing the risk of arteriosclerosis (hardening of the arteries).The best part of it is unlike Sencha or Matcha, this one is a herbal tea, which means it has no caffeine.

How to prepare Black soybean tea or kuromame tea?

It is very easy to prepare and you require just 5 minutes.

1. The very step is to roast a few black soybeans in a hot pan.

2. As soon as the skin starts to split, take the pan off the stove.

3. Boil some water and add roasted black soybeans and let it simmer for a few minutes.

You can have it when it is hot or cold. After brewing, you can enjoy eating the beans for extra fiber.

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Kuromame Tea: Drink THIS Japanese beverage to lose weight and improve health - PINKVILLA

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Kuonal Lakhapatiloved the fast-paced life that came with working at logistics startup LogiNext. But working with a rapidly growing company meant sleepless nights, stress, and demanding deadlines, which meant unhealthy food habits and no time for exercise. It was no surprise that Kuonal put on extra weight.

In a bid to get fit, Kuonal enlisted his wife and nutrition expert, Aayushi Lakhapatis help. At the time, she was toying with the idea of using meal replacement products as a way to become more healthy and strong.

Aayushi decided to make some nutritious food samples for her husband to try, and within 28 days, Kuonal lost 10 kg.

That is when the both of them realised they had stumbled upon a revolutionary idea that could help people lose weight by simply eating nutritious food. They founded a meal replacement products company, 23BMI, in Mumbai.

The founding team of 23BMI

23BMI primarily retails food products that replace the main meals of the day. These products are customisable/can be modified according to a persons specific dietary requirements.

A postgraduate in internal business from Kingston University, London, and a certificate holder in food and nutrition from Mumbai University, Aayushi is responsible for new product developments and client relationships at 23BMI. She also comes up with new, innovative solutions for her company's rapidly increasing client base.

Apart from making meal replacement products, 23BMI has a community of nutritionists on its platform who curate different lines of meal replacement products and engage with clients on the company's online platform.

One of the main challenges the company faced while setting up was developing the product from identifying trustworthy manufacturing partners and conducting human trials, to obtaining necessary certifications before the launch.

The startup also found that not everyone is open to trying new consumable health products, unless they are recommended.

"We had to choose the right marketing channel to reach out to a larger audience to overcome the challenge of scaling up faster in a B2C environment. Fortunately, we were lucky to identify the right partners who helped us speed up the product development phase, and launch the product, Kuonal, says.

The company instated several feedback channels to keep perfecting the product line, and established a robust, 24/7 communication network between health coaches and clients to support continuous supervision.

23BMI creates all its 100 percent organic products in-house.

The company outsources manufacturing, production, and order-taking to distributors across the country. Aayushi and Kounal design and prepare new meal replacement products themselves.

When regularly consumed, 23BMIs meal replacement smoothies coax the human body into a dietary ketosis state, which is where the body starts to burn stored fat to produce energy.

On an average, the entire process can help a person lose up to eight kilograms a month, and is done under the careful guidance of the companys health coaches.

23BMIs weight loss plan has a few variations depending on the goal weight, and the number of days one wants to consume the meal replacement products for. The weight management package costs between Rs 15,000 and Rs 45,000, depending on the number of meals and the duration of the programme.

The wellness industry is expected to hit Rs 1.5 lakh crore by the end of 2020, and grow at a CAGR of 12 percent over the next five years, according to estimates by FICCI and EY.

Those statistics are encouraging for a bootstrapped company like 23BMI, which has seen nearly 20 percent growth since inception in 2018, on a monthly basis. It clocked revenue of Rs 75 lakh in the current financial year, after investing close to Rs 20 lakh, initially.

The companys main competitors include startups like Prameya Health, AyurUniverse, and few others who use supplements in their health management programmes.

How has the coronavirus outbreak disrupted your life? And how are you dealing with it? Write to us or send us a video with subject line 'Coronavirus Disruption' to editorial@yourstory.com

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Health startup 23BMI can help you lose weight, stay healthy without hitting the gym - YourStory

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A PRE-PANDEMIC survey warned that 13million British adults are now classed as obese at a cost to the NHS of around 1billion a year.

Given that a UK report suggests two thirds of those who have fallen seriously ill with Covid-19 were either obese or seriously overweight, one wonders how many of those 13million are using these weeks of lockdown to make some life-saving changes that will not only benefit them but our over-stretched hospitals.

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After all, fast food restaurants have been closed and we all had much more time on our hands, so what better opportunity to rid ourselves of poor eating habits and get fit?

Better still, the likes of Joe Wicks and Mr Motivator are giving free, online fitness classes. All you need is a TV and the inclination.

But while many will have used this virtual house arrest to shake off some unhealthy old habits (smoking, sleeping tablets, etc), the reaction to Adeles weight loss suggests that, for some, her transformation is a betrayal of everything fat activists hold dear.

Of the 200,000 largely positive comments about the star losing an incredible seven stone, some sniped that she looked unhealthy (she doesnt) and questioned how she lost it the inference being that she had succumbed to having a gastric band.

But as Pete Geracimo, her former personal trainer, points out: It was never about getting super-skinny. It was about getting her healthy.

Not least, one suspects, for the benefit of her seven-year-old son Angelo. He adds: She embraced better eating habits and committed to her fitness and is sweating! I could not be prouder or happier for her.

Hear hear. Yet alarmingly, research out earlier this year found that millions of women hid their efforts to slim for fear of being mocked or labelled anti-feminist.

Saints preserve us. The truth, of course, is that if someone is deeply insecure about their own weight, they either pooh-pooh or, worse, lash out at the efforts of those who manage to transform their lifestyle via willpower and hard slog.

Far easier to do that than take a look at our own bad habits and attempt to change them. True, there are plenty of people who look overweight but are physically fit.

And there are plenty of skinny malinkies who cant run for a bus without needing oxygen. At the end of the day, being happy within yourself is not about how you look, but how you feel.

And if you feel that you are unfit thanks to lousy eating habits and lack of exercise, then you should be able to do something about it without being taken to task by those who dont have the same self-discipline.

Particularly as last weeks research from the University of Liverpool found that obesity increased the risk of dying from coronavirus by 37 per cent. You cant argue with that.

BOREDOM at Moore Towers has reached such a crisis point that, on Sunday, I linked my iPhone to our portable speaker, put the songs on Shuffle and said we had to endure enjoy whatever track came up.

At first there were plenty of goodies from Floyd, Bowie, Prefab Sprout and Talk Talk, but then Twinkle Twinkle Little Star popped up, followed by You Spin Me Round by...Alvin And The Chipmunks.

For the record, our youngest is now 16. It seems its not just the kitchen cupboards that need a clear-out.

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BRINGING 66million people out of lockdown was never going to be easy.

But Boriss much-trumpeted grand statement was a damp squib thats left us as confused as Adam and Eve on Mothers Day.

In a nutshell, four-year-olds will be able go to school with lots of kids theyre not related to but not see other kids in their family, we can go to work with colleagues but not have a chat with them in their garden, we can do unlimited exercise which we could have done anyway, if we go abroad we have to self-isolate for a fortnight...unless its France, and you can drive to other destinations but not too far, whatever that means.

As for stay alert, is that the same as Police 5 presenter Shaw Taylors old mantra of: Keep em peeled?

Except we could actually see someone coming at us with a crowbar.

A virus that can fit 48squillion times on to the head of a pin might prove harder to spot.

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GIVEN that the use of face masks is being actively encouraged but not the professional ones needed by key workers, a number of DIY versions are being suggested.

Some involve an element of seamstress skills, but for those who want a quick and effective mask they can drum up with the minimum effort, this is my favourite.Find a bandana or any other square of material and fold it in half, then half again.

Loop a childs hair tie (a rubber band will work but not as well) over each end until it resembles a boiled sweet, then fold over the ends to meet in the middle (see pics, above).

Then simply place the wrong side against your face, loop the hair ties around your ears, and voila.

Youre welcome.

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FASHION designer Freya Edmondson daughter of Ab Fab star Jennifer Saunders and actor Ade Edmondson has posted this photo of herself doing a sumptuous, heart-opening backbend, while writing on a notepad.

Freya, who teaches free online yoga courses, is just 29 and, therefore, wonderfully flexible.

As a former enthusiastic gymnast, it reminds me of my youth, when I would watch TV while doing the box splits with my legs stretched out at right angles to my body.

With my 58th birthday looming this Sunday, if I attempted it now it would take four paramedics and a system of pulleys to get me on my feet again.

BEWARE

THE wife of former Manchester United star Angel di Maria has branded the city a s***hole and says she feared that the women there would kill her.

They will now.

ACADEMICS may lord it over the rest of us when it comes to quadratic equations, subatomic phenomena or the three components of the epidemiological triangle, but when it comes to common sense they are often found lacking.

Quite how Professor Lockdown (aka Neil Ferguson) thought he could preach to the rest of us about social distancing while inviting his mistress to his house is anyones guess, but he did, and now hes rightly had to resign for hypocrisy if nothing else.

He says: I accept I made an error...I thought I was immune.

From Covid-19...or criticism?

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THE latest series of Killing Eve may have had a lukewarm reception from critics, but central character Villanelles fashion choices have been attracting a lot of attention.

One frock cost 1,500, another 1,400, and her red leather catsuit would set you back an eye-watering 1,942.

I know these are desperate times for all businesses, but since when have fashionistas been clamouring to get their clothes on the back of a psychotic murderer?

It gives a whole new meaning to dressed to kill.

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HAIRDRESSERS are to stay closed until July 4 at the earliest.

Comment

THE SUN SAYSCoronavirus may be with us for years - we simply must get back to work

Comment

ALLY ROSSGemma Collins' new ITVBe lockdown show proves she's a self-obsessed tyrant

Comment

Leo McKinstryBoris's travel plans will ruin Great British escapes and hurt the economy

Comment

TREVOR KAVANAGHLockdown will turn out to be a terrible mistake & bug is holding us ransom

Comment

THE SUN SAYSBoris must be blunt with the public about the urgency of reopening the economy

Up to now I have been making do with the occasional fringe cut using a pair of nail scissors.

But given that my style (for want of a better word) is supposed to be choppy bob, and I now resemble Richard lll, it seems I will have to tackle the rest of it too.

Worse, The Bloke will have to do the back and, God forbid, baldly (no, thats not a typo) go where no man has gone before.

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Why cant people like Adele lose weight without trolls having a go despite it being life-saving? - The Sun

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Every day, food influencer Eloise Head posts photos of treats like doubled-up burgers dripping with cheese, gooey brownies stuffed with peanut butter cups, and stacks of pancakes piled high with toppings and smothered in lashings of melted chocolate.

But the most common questions Head gets asked by the 400,000 people who follow Fit Waffle (and her newly-launched cooking account Fit Waffle Kitchen) aren't about her recipes or favorite restaurants, but her body.

"The most common questions I get asked are, 'Do you eat all this food?' and, 'How do you eat all this food and stay in shape?'" she told Insider.

Eloise Head's Snickers Cookie Bars. Eloise Head

While 26-year-old Head doesn't post photos of herself that often, she shares enough for her followers to see that she has an enviable physique.

And the trouble is, many people believe that to look like Head, you can't eat any of the foods she posts.

Through going on her own journey with food, fitness, and her body, Head learned that this simply isn't the case there's no such thing as "good" or "bad" foods, no single food will make you gain weight, and everything can be enjoyed in moderation.

Eating too much of any food, thus being in a calorie surplus and taking in more energy than you burn, leads to weight gain.

While some foods are more calorie-dense than others, that doesn't mean you can't still eat them and maintain or even lose weight.

"There are no specific foods that make you gain weight," Head, who is a qualified personal trainer, told Insider.

"Everything can be enjoyed in moderation, without feeling guilty afterward or feeling like you're moving further away from your goals. Even if your goal is fat loss."

Head says everything can be enjoyed in moderation. Eloise Head

Weight loss specialist and board-certified cardiologist Dr. Luiza Petre previously reinforced this point to Insider's Sophia Mistrokostas when explaining how even "healthy" foods like those prioritized on the Mediterranean diet can lead to weight gain if overconsumed.

"Calorie-loaded foods that have a healthy halo like avocado, nuts and excessive amounts of olive oil are very caloric dense and can pack fat quickly on your waistline," Petre said.

When it comes to losing weight, nutritionist Graeme Tomlinson previously stressed to Insider that "a calorie deficit is the only exercise required," regardless of which foods you eat.

"Ensuring you enjoy what you eat, and can sustain the deficit and mode of energy expenditure, you have a greater chance of consistently losing fat over time," he said.

Of course, eating lower-calorie foods will allow you to eat larger quantities while remaining in a calorie deficit, but it'll be a lot easier to maintain that deficit if you let yourself enjoy some of your favorite foods every once in a while.

While Head, of course, enjoys the foods on her Instagram pages, she doesn't eat the whole tray of brownies in one sitting she eats a portion. And this moderation is the key.

"I definitely don't eat the whole of everything I bake," she said. "I generally eat the bits I want, then share the rest with my family.

"Once lockdown is over, I hope to share it with my friends that live further away, too."

Oreo-layered brownies feature on Fit Waffle Kitchen. Eloise Head

Head also points out that she has been running Fit Waffle full-time since July 2019 the brand is her job, it's not a food diary.

"It's important to understand that Fit Waffle is my business," she said.

"The page is to showcase my recipes and foods I have tried from restaurants and food traders. The page does not showcase my diet."

She added: "I eat my food in moderation alongside a balanced diet and I stay active. There really are no secrets."

Although Head works out a lot, she trains because she loves fitness, and not to "counteract" the food she's eating.

"I generally train five to six times a week for about an hour and a half. All my workouts are weights focused, as opposed to cardio," she said.

A post shared by London Food Content Creators (@fitwaffle)Apr 15, 2020 at 1:23pm PDT

Each workout begins with a 10-minute warm-up, then stretching and foam rolling.

"I'm usually training to gain or maintain muscle and improve my strength and performance, rather than to lose weight," Head added.

She also walks every day, but mainly for her mental health, and just because she enjoys it.

Head admits that she hasn't always had such a good relationship with food.

About eight years ago when she was 18 and at college, Head, like many people, decided to go on a diet before a holiday.

"I basically cut out all foods I decided were 'bad' for me and only ate foods that I considered to be 'healthy,'" she said.

"For example, I would allow myself to eat sweet potatoes, but not white potatoes. Anything like chocolate, cookies, or fried food was completely off-limits."

Eloise Head when she followed a restrictive diet (left) and now. Eloise Head

Needless to say, Head lost a lot of weight by eating very few calories of the foods she deemed "good," and said her blood pressure was very low. She'd even get a head-rush multiple times a day where she'd black out for a few seconds at a time.

"My friends and family started to voice their concerns about my weight, but in my eyes, I still wasn't lean enough," Head said.

"After my holiday, I continued with my 'diet' and lost even more weight.

"I had fights with my mum when I wouldn't eat what she gave me for dinner. I told her that I was being healthy, because I wasn't eating 'bad' foods and I frowned on her own diet."

Head's turning point came when she first learned about a way of eating called "If it fits your macros" (IIFYM), also known as Flexible Dieting, while studying for her personal training qualification.

Macros are the three macronutrients your body needs in large amounts: carbohydrates, fat, and protein.

IIFYM or Flexible Dieting is a way of approaching nutrition that's popular in the fitness community, and essentially shows you how you can fit any food into your diet and still hit your calorie and macro targets.

"This completely changed my mindset about food being 'healthy' or 'unhealthy,'" said Head." I could see foods broken down into their macronutrient values; protein, fats, and carbohydrates."

The more Head educated herself, the more she realized her goals had shifted.

No foods are off-limits any more. Eloise Head

"I did a lot of research and started to eat towards my goals, which were now to gain muscle and start putting on weight," she said.

It took Head some years of educating herself to get to a position where she felt she could relax and eat intuitively though.

"I tracked my calories and macronutrients religiously for about four years before I felt comfortable enough to listen to my body and enjoy all foods in moderation," she said.

"My relationship with food and my body is still not perfect, but I've come a long way from where I started and have gained a lot of knowledge along the way."

Read more:

How calorie-counting actually helped me develop a healthier relationship with food

I lost 35 pounds in 6 months without going on a diet, and it taught me 7 lessons about eating for healthy fat loss

A self-taught baker's 3-ingredient dessert recipes have made her a TikTok sensation

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