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Cookbook author Urvashi Pitre says she has struggled with her weight for years. Five years ago, she had weight loss surgery and committed to a low-carb ketogenic diet. She has lost 80 pounds and kept them off.

She shares 100 international keto-friendly recipes in her new cookbook, Easy Keto in 30 Minutes, including a number of dishes from her native India. There also are keto versions of popular dishes from Korea, Italy, the Middle East and Mexico.

This Stuffed Poblanos recipe from the book has an estimated 10-minute prep time and takes a mere six minutes to cook.

Find more of her keto recipes on her food blog, twosleevers.com.

Roasting the poblanos as you cook the ground beef makes this recipe move ahead lickety-split. Air frying is also an excellent way to roast these peppers. If you have time, you can roast the peppers whole and then stuff them whole. But this way works faster: just laying them flat and layering them with beef and cheese. This feeds four people with the accompaniments or probably two hungry people without the added fat from the sour cream and guacamole.

Makes 4 servings

4 large poblano chiles, halved and seeded1 tablespoon vegetable oil1 pound 85 percent lean ground beef1 tablespoon plus 1 1/2 teaspoons taco seasoning1/4 cup chopped fresh cilantro, plus more for garnish1 cup shredded Mexican blend cheeseFresh lime juice (optional)Sour cream (optional)Guacamole (optional)

Place an oven rack 6 inches below the broiler. Preheat the broiler on high.

In a medium bowl, toss the poblano halves with the oil. Arrange, cut side down, on a rimmed sheet pan. Broil until the outsides are charred and blistered, about 4 minutes.

Meanwhile, heat a large skillet over high heat. Add the ground beef and cook, breaking up the meat with a wooden spoon, until cooked through, 6 to 7 minutes. Stir in the taco seasoning and the 1/4 cup cilantro.

Fill each poblano half with ground beef and top with cheese. Arrange pepper halves on the baking pan. Broil until the cheese is melted and bubbly, 2 to 3 minutes.

Garnish with additional cilantro, if desired. Serve with a sprinkle of lime juice, sour cream and/or guacamole, if desired.

Even faster tip: You can prepare the poblanos and seasoned meat ahead of time and only assemble one, two or all four halves as needed. Youll need to reheat the pepper halves and meat in the microwave before stuffing the pepper halves, topping with cheese, and then broiling.

Per serving: 409 calories; 27 g total fat; 11 g total carbs; 10 g net carbs; 1 g fiber; 1 g sugars; 30 g protein

Excerpted from Easy Keto in 30 Minutes: More than 100 Ketogenic Recipes From Around the World by Urvashi Pitre. Reproduced by permission of Houghton Mifflin Harcourt. All rights reserved.

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Stuffed poblanos adhere to Keto diet - The San Diego Union-Tribune

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If youre among Britains 600,000 vegans or the estimated 400,000 more who signed up for Veganuary this year the chances are you stopped eating animal products for the sake of the environment and your health. But is it possible the worlds fastest growing consumer trend could actually damage, not improve, your health?

No one disputes that eating more fruits, vegetables, wholegrains, and nuts is good for us and reduces the risk of chronic diseases. But scientists and nutritionists are concerned that increasingly popular fake meats and vegan fast foods may be less healthy than their meaty alternatives.

British shoppers spent 474 million on meat-free groceries including burgers, sausages, ready meals and cooking ingredients in 2019,according to consumer analysts Kantar Worldpanel -an increase of eight per centon the previous year. This doesnt include sales of vegan fast food, which are also skyrocketing.

There are also fears that vegan diets may be causing deficiencies in crucial nutrients that could lead to serious health problems.

The whole issue of plant-based food products is highly contentious. Scientists at a farmers conference in London last week hit back at veganism, suggesting that eating tofu a key protein source in many plant-based diets might be worse for the planet than consuming some meats. The theory is that per unit of protein absorbed, tofu production may cause more greenhouse gas emissions than rearing lamb, pork and chicken for the table. The fact that Almond Milk production requires vast amounts of water in drought afflicted California is also well documented.

But whatever the environmental pros and cons, the booming meat-free food market has prompted some doctors and scientists to question whether some of these products can be considered part of a healthy diet.

From meatballs and burgers to goujons and bacon, imitation meats are everywhere. Some have been around for years. Seitan, traditionally used in Chinese cookery, is a form of wheat gluten. Many people are familiar with Quorn, although perhaps not what its made from: mycoprotein, a protein derived from fermented fungi, bound with egg albumen or potato protein. And soy products like tofu and tempeh have long been used in Asian cuisine as a plant-based substitute for meat.

All these products are good sources of protein and are nutritious to varying degrees. But some, like tofu and seitan, are not complete sources of protein, that is, they dont contain all the essential amino acids our bodies need. And seitan and Quorn are also highly processed. Seitan would not be suitable for anyone with gluten or wheat sensitivity.

In recent years, a new generation of high-tech products made from plants has been developed to recreate the exact taste, texture and appearance of meat. Most are also highly processed, made with a long list of unfamiliar ingredients and sometimes new production methods. The Vegan Butcher range, for example, lists soy structure as the main ingredient in its Chickened Out Burger and Good Karma Shawarma. According to Unilever, which owns the brand, this is an amalgam of water, soy protein, wheat starch and wheat protein.

Beyond Burgers, which are sold in over 25,000 food outlets worldwide and found in the meat section of some British supermarkets, are among the new fake meats made with pea protein isolate. Impossible Burgers, widely available in the US but not yet approved for sale in the UK, are made with soy leghemoglobin. This is a protein that carries heme, an iron-rich molecule that gives the futuristic patties their realistic colour, aroma, and flavour of meat.

Last year, Harvards School of Public Health researched these novel meats to determine whether they could be considered part of a healthy diet. They concluded that the answer was far from clear as studies are currently inconclusive.

However, Chair of the Department of Nutrition, Dr Frank Hu, said it couldnt be assumed that the health benefits of fruits, vegetables, wholegrains and nuts were the same as meat alternatives made with highly processed plants. Food processing can lead to the loss of some nutrients and phytochemicals naturally present in minimally processed plant foods, he said.

Dr Hu added that a recent study by the National Institute of Diabetes and Digestive Kidney Diseases found a link between highly processed foods and weight gain, although the study did not focus on meat substitutes.

Other ingredients going into industrially processed vegan food are also causing concern. To make these products taste as similar as possible to their non-vegan counterparts, manufacturers include many additives, notably salt and sugar. Recent research by content agency JBH revealed some vegan fast food contained much more salt and sugar than their non-vegan equivalents. Subways Meatless Meatball Marina, for example, clocked in with 3.6g of salt (more than half the recommended daily intake of 6g) and 19.3g of sugar. Its Meatball Sub contained much less of both, with 1.9g and 13.5g of salt and sugar respectively.

Many popular brands of meat-free burgers, sausages and bacon sold in supermarkets also contain high levels of salt, according to Mhairi Brown, a nutritionist and policy co-ordinator with campaigning group Action Against Salt. She says the main problem with these products is the perception encouraged by food manufacturers that vegan food is healthy simply because its made from plants. They often use green or orange packaging, and also the term plant-based, to create a health halo, she says. People think these products are healthy when that might not be the case at all.

Registered dietitian Sophie Medlin agrees. Many people think that if a food is vegan its healthier, she says. The truth is there are some really great vegan alternatives to meat and dairy but there are plenty of food manufacturers simply chasing the vegan pound. Fast food outlets that have questionable animal welfare standards and poor environmental practices are selling vegan alternatives that are often deep fried carbohydrates in a bun.

Although vegan advocates insist its perfectly possible to eat a well-balanced plant-based diet, nutritionists are concerned that many people simply dont manage it. Medlin reports a rise in cases of anaemia at her clinic caused by vitamin B12 deficiency. Essential for brain and nervous system function, B12 is naturally found in animal products but generally not in plant foods unless theyre fortified, putting vegetarians and vegans at particular risk of deficiency. Untreated, vitamin B12 deficiency can cause irreversible nerve damage.

Its not surprising that demand for B12 injections and intravenous drips at high street vitamin salons is rising. We administer 20% more B12 shots now than we did two years ago, and around 30% of our customers are vegetarian or vegan says Richard Chambers, founder of Get A Drip. In December alone we administered 528 B12 products. (Medlin strongly advises against going to high-street providers for injections or IVs).

Another cause for concern is the risk to bone health caused by calcium and vitamin D deficiency, says Professor Ian Givens, director of the Institute of Food, Nutrition and Health at Reading University. Research shows vegans have lower bone mineral density and fracture rates nearly a third higher than the general population, with teenagers and post-menopausal women were particularly at risk. Vegetarian and vegan diets can increase the risk of reduced bone strength and special care is needed to ensure adequate intake of the key nutrients, Prof Givens says.

We also think there may be a lot of new food allergies issues emerging due to the ingredients being used in some vegan foods, adds Professor Chris Elliott, from the Institute of Global Food Security at Queens University Belfast. It is too early to say this for sure for we are watching this closely. We doubt very much about how well nutritionally balanced many of these are and will only add to the issues were already concerned about. He says long-term studies into these foods are needed.

Heather Russell, a dietitian for the Vegan Society, says anyone considering opting for a plant-based diet needs to educate themselves about good nutrition and healthy protein sources(nutrition information is available on their website). Whether youre vegan or not, its a good idea to use food labels to keep an eye on added fat, salt and sugar and limit highly processed foods, she says.

Experts do agree that the healthiest diet includes an abundance of minimally processed plant foods, and limited amounts of the highly processed stuff. But just because food is made from plants doesnt mean its good for you -that bag of crisps might be vegan, but its not health food.

The rest is here:
Is a vegan diet really as healthy as we think? - Telegraph.co.uk

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From a bulky 108kg to 56kg, Jen Atkin went on to win the Miss Great Britain 2020. Picture via Instagram/ jenatkinuk

KUALA LUMPUR, Feb 27 A 26-year-old changed her diet,changed her diet and said goodbye to a sedentary lifestyle after being dumped by her ex-fiance.

Jen Atkin, an aviation administrator from Ulceby, England dropped over 52kg in weight, went on to win Miss Scunthorpe then Miss England 2018 runner-up before coming back from a pageant hiatus to get married to be crowned Miss Great Britain 2020.

Eating better now, Atkin told Bored Panda that she didnt follow a set diet.

I eat so much better, I dont follow a diet but I think about what I eat so much more. I still enjoy meals out but dont binge like I used to!"

"I go to the gym five times a week now and I love it, its become a staple part of my life and has helped me in so many ways.

It took her two years to drop her weight from around 108kg to 56kg.

This years Miss Great Britain which supported the organisation Cancer Research UK and Alexs Wish which raises awareness about Duchenne muscular dystrophy), raised more than RM228,000 for the worthwhile causes.

If you want to follow Atkin's footsteps but find yourselves without energy or motivation, she said its all about consistency and small steps.

My biggest advice would be to take every day as it comes.

Imagine where you could be in three months time and just keep chipping away! Consistency is key and its a lifestyle change!

View original post here:
English woman drops 50kg after a change in diet, hitting the gym goes on to win Miss Great Britain - Malay Mail

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There's a lot of chat around plant based and meat free and veganism these days. Whether its a fad or a long term thing, whose embracing it, whose not, what it means for New Zealanders, for farmers, and so on.

We seem to be dedicating a lot of column inches to how we eat, what we eat, why we eat, what we shouldnt eat.

And while Im a big fan of food fads and trying new things and evolving with food based patterns, I do wonder if we all just need to,in the words of Taylor Swift, calm down.

Does it really matter if youre doing meat-free Mondays and Im not?

Does it matter if youre vegan and Im not?

Does it matter if youre dairy and gluten free and Im not?

To me it feels like the crossfit trend, those that are doing it, have to talk about it a lot.

And they can get a wee bit judgey if youre not doing it too.

The famous meme if youre a vegan and you dont tell anyone, are you still a vegan.. rings true.

I get the share the philosophy thing, I get the health benefits youre enjoying and want to shout from the rooftops, but an all kale and spinach diet may just not be for everyone.

Shopping organic and free range at farmers markets may not be an option for everyone.

And it doesnt mean those people arent interested in saving the planet or care about the environment, it just means were all different and were allowed to do our own thing.

Not everything has to be a movement.

For the record, I am majority plant based by choice, but I do eat meat, just not that often by preference.

I learned early on that not many people want to hear about what youre eating.

I recall trying to tell my parents one day about the merits of eating raw and plant based and their eyes glazed over and my Dad interrupted me and said oh nooooooo, not a lettuce leaf lecture, no, boring, we get it, you like salad, yawn..

Hes right of course. Inflicting your weird food preferences on others should be reserved for the handful of people whore actually interested and outright ask you what you eat. Which is not many.

But I raise this because I see the huge pressure and confusion around food, kids dont know what to eat anymore, theres a lot of second guessing. Is this good for me? Is it bad?

I cant help thinking our grandmothers were probably onto something when they said everything in moderation.

Link:
Kate Hawkesby: Why do we share our diet plans with everyone? - Newstalk ZB

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Lacuna Juice and Yoga. Photo by Sara Ford

Meal options abound for vegan, vegetarian, and gluten-free diners at the eight-month old wellness oasis.

Dont let the name fool you: Lacuna Juice and Yoga caters to more than just practicing yogis and steadfast juicers. The spaces bright cafe accommodates an expansive egg, dairy, and, meat-free lineup that gives everyone something to love.

Were not trying to be restrictive or convert people to veganism, says owner Megan Whiteside, who opened the wellness oasis with her husband Trent DeMichele in June. We just want to broaden peoples dietary horizons.

The completely organic menu, much of which is or can be made gluten-free and touts everything from soups and salads to toasts and breakfast bowls, certainly demonstrates the infinite possibilities of plant-based eating. One such prospect is the curry coconut wrap ($11). Inside its paper-thin shell (comprised of raw coconut meat and salt), layers of limey kale, tender tofu, shredded carrots, sliced jalapenos, ground shiitake mushrooms, and a miso-ginger-and-peanut butter spread work together in piquant harmony.

The brainchild of this hand-held delight and the rest of Lacunas culinary offerings is former Table 6 executive chef Carrie Shores. Shores, who sources ingredients from neighboring Altius Farms and Growers Organic, draws on her fine-dining experience and nearly lifelong veganism to lead Lacunas kitchen with minimal food loss. Were working toward zero-waste, says Shores. So I try to cross-utilize ingredients as much as possible.

That means any leftover cashews from the cafes protein-packed golden milk ($11) are incorporated into the shortbread crumble for the dulche de leche apple pie overnight oats ($6) or made into a spicy cashew ranch. The cold-press process, which makes each of Lacunas 10 juices so vitamin-rich, is also unfortunately its biggest food-waste culpritthough thats just about the juices only drawback.

In addition to ample nutrient goodness, the juices are wildly drinkable. For instance the Ruby ($11), which claims benefits such as increased energy, sings with fruity naval orange and Anjou pear while only hinting at its more polarizing components (beet, turmeric, fennel, and lemon). The grass-hued Jade ($11) delivers a tart and citrus-y herbaceousness while packing the superfood punch from greens like spinach and kale.

The yoga classes are similarly approachable, offering a gentle combination of Vinyasa, Hatha, and Katonah techniques. Yoga mats are provided by the studio (!) as well as blankets, blocks, and other props to make the practice as comfortable as possible.

In January, the cafe added gluten-free, almond flour weekend waffles (only available Saturdays and Sundays) to its menu. With vegan-made toppings like sliced bananas, caramel, and chocolate sauce, the dish is yet another reminder from Lacuna that even with dietary restrictions, theres still plenty of deliciousness to be had.

2590 Lawrence St.

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Lacuna Juice and Yoga Defeats Dietary Restrictions - 5280 | The Denver Magazine

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A small study in England reinforces the idea that exercise should be part of the plan to lower weight. Some of the new exercisers, while saying they still like cookies, were less likely to want the cookie. Public health news is on food label information, rare diseases, clinical trial data, sodium in sports drinks, eating disorders, cognitive screening debate, and E. coli outbreaks, as well.

The New York Times:How Exercise Might Affect Our Food Choices, And Our WeightTaking up exercise could alter our feelings about food in surprising and beneficial ways, according to a compelling new study of exercise and eating. The study finds that novice exercisers start to experience less desire for fattening foods, a change that could have long-term implications for weight control. The study also shows, though, that different people respond quite differently to the same exercise routine and the same foods, underscoring the complexities of the relationship between exercise, eating and fat loss. (Reynolds, 2/26)

The New York Times:Are Foods Labeled Low Sugar Misleading Consumers?The label on Honest Teas organic peach-flavored iced tea has a reassuring message for people who want a beverage that is not too sugary: Just a Tad Sweet, the label states. But a single serving of the beverage, the amount in one 16.9 ounce bottle, has 25 grams of added sugar, equivalent to six teaspoons of table sugar. That is half the daily limit for added sugar intake recommended by the federal government. (O'Connor, 2/26)

Stat:College Student With Progerioa Is Heartened By Medical AdvancesIn many ways, Emerson College freshman Meghan Waldron seems like a lot of students in Boston. She adores pop star Ed Sheeran. She loved the latest film version of Little Women and wants to see it 10 more times... She also has progeria, one of the worlds rarest diseases. The fatal genetic disorder causes premature aging and has been identified in only 169 children and young adults alive today worldwide, although researchers estimate that as many as 400 have it. (Saltzman, 2/25)

Stat:Clinical Trial Sponsors Must Publish 10 Years Of Missing Data, Judge RulesFor years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a 10-year gap in data that now must be made publicly available. Now, potentially hundreds of universities, drug companies, and medical device manufacturers are on the hook to release previously unpublished data. (Facher, 2/25)

Reuters:Sports Drinks Cannot Assure Healthy Sodium Levels In Endurance AthletesElite runners often turn to sports drinks to keep essential minerals in balance, but a new study shows these products can actually contribute to a dangerous medical condition when temperatures are high. The best way to avoid life-threatening hyponatremia - when the body's sodium levels dip dangerously low - is by training better, keeping fit, and avoiding excess water or sports drink consumption, researchers report in the Clinical Journal of Sports Medicine. (2/25)

NBC News:Stereotypes Around Eating Disorders Keep People From Seeking The Treatment They NeedLauren Chan has been in the fashion industry long enough to have a strong opinion about how it contributes to disordered eating. The 29-year old is a former plus-size model and editor at Glamour magazine and says that fashion, entertainment and the media perpetuate the myth of an idealized body type that for most people, is unattainable. We see 5,000 ads a day, all featuring the same kind of image, she says. The message we receive is clear, but if you look around at the people in your life, very few look like that. (Loudin, 2/25)

Kaiser Health News:U.S. Medical Panel Thinks Twice About Pushing Cognitive Screening For DementiaA leading group of medical experts on Tuesday declined to endorse cognitive screening for older adults, fueling a debate that has simmered for years. The U.S. Preventive Services Task Force said it could neither recommend nor oppose cognitive screening, citing insufficient scientific evidence of the practices benefits and harms and calling for further studies. The task forces work informs policies set by Medicare and private insurers. Its recommendations, an accompanying scientific statement and two editorials were published Tuesday in the Journal of the American Medical Association. (Graham, 2/25)

Kaiser Health News:Trusting Injection Drug Users With IV Antibiotics At Home: It Can WorkTwo mornings a week, Arthur Jackson clears space on half of his cream-colored sofa. He sets out a few rolls of tape and some gauze, then waits for a knock on his front door. This is Brendas desk, Jackson said with a chuckle. Brenda Mastricola is his visiting nurse. After she arrives at Jacksons home in Boston, she joins him on the couch and starts by taking his blood pressure. Then she changes the bandages on Jacksons right foot. (Bebinger, 2/26)

Chicago Tribune:FDA Sends Warning Letter To Jimmy John'sThe U.S. Food and Drug Administration issued a warning letter Tuesday to sandwich maker Jimmy Johns and one of its suppliers, saying vegetables the restaurant chain served in the past seven years are linked to five outbreaks of E. coli and salmonella. The agency accused Champaign-based Jimmy Johns of engaging in a pattern of receiving and offering for sale adulterated fresh produce, including clover sprouts and cucumbers. (Jimenez, 2/25)

See more here:
Starting Exercise Programs Just Might Lead People To Run Away From Fatty, High Calorie Foods, Researchers Say - Kaiser Health News

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Its no secret that the Peloton boom is in full effect, with connected fitness equipment ranging from smart bikes to treadmills, rowing machines, boxing bags, and weight training stations. While they all feature some kind of streamable fitness class that you can watch from the device as you work out, one thing theyre all missing is the ability to tell you if youre doing the exercise properly.

Tempo is pitching something different. Yes, its yet another connected fitness machine that has classes you can stream live or on-demand, but it comes with Microsofts Azure Kinect built in to track your form in real time during each exercise. The armoire-shaped machine has a 42-inch HD touchscreen display that streams videos in 4K and offers classes ranging from HIIT, strength training, cardio, and yoga. It also has storage racks behind and below the screen to hold barbells, weighted plates, a foam roller, a wrist-worn heart rate monitor, and a yoga mat that all come as part of the starter kit.

While Tempo does have a camera and microphone built into the machine, the company says these features arent activated out of the box. It uses solely the Azure Kinect camera to watch the users form and employs dots to plot the users movements, locating their muscles and joints to ensure each lift, squat, and slide is done properly.

In my brief demo with Tempo, it automatically told me to sit back a bit more during a squat so my knees didnt go over my toes. Once I corrected this form, the on-screen prompt also told me I was now doing it right and moved on with the exercise. At the end of the exercise session, you can go over a summary of the exercises you did and whether they required any feedback to correct your form for next time. If you never corrected your form during the exercise, you can also click on the feedback to watch a tutorial video of what youre actually supposed to be doing.

As you can see in the GIF below, Tempo located my bones and joints and tracked each movement in real time (including the moment I purposely tried to trigger the AI by leaning back too far on a bicep curl). It also anonymizes my face and what I was wearing by using solely dotted plots.

One thing I appreciated with Tempo is that the classes are done in tandem with the coaches themselves. This was something I found less personable and repetitive with Tonal, a weight training system that uses prerecorded exercise videos to loop users through their sets. Tempo also focuses on doing the exercise correctly versus doing a specified amount of reps, though the machine does suggest weights and how many reps you should aim for based on your initial strength test, its more about how many you do right within the 30- to 60-second allotted time period per exercise. The computer vision also helps to count those reps and shows on-screen how many youve done.

As with most other smart fitness equipment, Tempo does come with a monthly content subscription fee of $39 on top of the equipment price of $1,995 plus tax and shipping / installation. At this time, Tempo only offers one live class daily, but it promises to regularly update the library with new programs and one-off sessions. You can also use the app to browse the schedule and save any class or programs you want to do and add them automatically to your calendar.

Tempos starter pack comes with a standard set of weights that add up to 100 pounds when attached to the 25-pound barbell, but Tempo says users can use their own plates if they want something heavier since the barbell is standard sized and isnt proprietary. Similarly, users can also use their own dumbbells for exercises if they elect not to use the included set.

Tempo launches today and can be reserved with a $250 deposit. It will ship this summer first in the Bay Area and globally in the following few months.

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Tempo is a home gym that uses computer vision to track your form - The Verge

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Feb. 26, 2020 13:00 UTC

Taihos in-licensing facilitates global development and commercialization of zimberelimab as a monotherapy and as a combination backbone for Arcuss and Taihos oncology portfolios

Zimberelimab exhibits clinical activity and a safety profile consistent with those of currently approved anti-PD-1 therapies

Broad development program delivering randomized data in 2020 for zimberelimab in multiple novel combinations, including with AB154, Arcuss anti-TIGIT antibody, and with AB928, the first and only dual A2a/A2b adenosine receptor antagonist in the clinic

HAYWARD, Calif.--(BUSINESS WIRE)-- Arcus Biosciences. (NYSE:RCUS), an oncology-focused biopharmaceutical company working to create best-in-class cancer therapies, and Taiho Pharmaceutical Co. Ltd., (Taiho), today announced Taihos exercise of its option to exclusively license zimberelimab, an anti-PD-1 monoclonal antibody, from Arcus Biosciences for commercialization in Japan and certain other territories in Asia (excluding China). This is Taihos second exercise of an Arcus program and follows their 2018 decision to license AB928, the first and only dual A2a/A2b adenosine receptor antagonist in the clinic.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200226005249/en/

We are happy to expand our collaboration with Arcus, with their ability to produce exceptional molecules and to thoughtfully execute on unique trial designs, said Masayuki Kobayashi, President and Representative Director at Taiho. This next stage in the partnership between our two companies further reinforces Taihos commitment in developing and delivering new treatment options to patients in need.

Taiho has been a great partner for Arcus, and we highly value the long-term relationship that we have built with our colleagues at Taiho, said Terry Rosen, Ph.D., Chief Executive Officer of Arcus. This second option exercise provides additional opportunities to fully leverage the therapeutic potential of our portfolio of clinical programs. We look forward to multiple AB928 and zimberelimab expansion study readouts starting in mid-2020 and to early randomization data prior to the end of the year.

Zimberelimab has demonstrated a favorable safety profile as monotherapy and in combination with other agents, including AB928 and AB154. Zimberelimab is part of a broad development program with Arcuss lead asset, AB928, in clinical studies that include prostate, colorectal, non-small cell lung, pancreatic, triple negative breast and renal cell cancers. In addition, zimberelimab is currently in a randomized Phase 2 study for the treatment of first-line metastatic non-small cell lung cancer, evaluating zimberelimab in combination with AB154, Arcuss anti-TIGIT monoclonal antibody, with and without AB928.

Arcus licensed zimberelimab in 2017 from WuXi Biologics to provide flexibility and optionality for clinical development of innovative precision combination regimens and potential commercialization. Arcus holds worldwide rights to zimberelimab excluding China and Thailand. Gloria Biosciences, which licensed the rights to zimberelimab for China, recently presented data from its independent development of zimberelimab that demonstrated impressive anti-tumor activity in classical Hodgkins lymphoma. In January 2020, Gloria Biosciences submitted its application to the Chinese National Medical Products Administration (NMPA) to seek marketing approval in this indication.

In December 2019, Arcus received a payment from Taiho for the exercise of its option to license zimberelimab, and Arcus is eligible to receive additional clinical, regulatory and commercialization milestones of up to $275 million, as well as royalties on net sales, for this program.

About Zimberelimab

Zimberelimab, an anti-PD-1 monoclonal antibody, was in-licensed by Arcus to enable the development of precision combination regimens with full line-of-sight to the commercialization of innovative therapies for all patients who may benefit. Clinical studies with zimberelimab have demonstrated clinical activity and a safety profile that are consistent with those of currently approved anti-PD-1 therapies. The most advanced study with zimberelimab is a randomized Phase 2 study for the treatment of first-line metastatic non-small cell lung cancer, evaluating zimberelimab in combination with AB154, an anti-TIGIT monoclonal antibody, with or without AB928, the first and only dual A2a/A2b adenosine receptor antagonist in the clinic. Zimberelimab is also being evaluated as a monotherapy in a tumor-agnostic, biomarker-selected Phase 1b trial for cancers with no approved anti-PD-1 treatment options.

About AB928

AB928, the first and only dual A2a/A2b adenosine receptor antagonist in the clinic, is designed to maximally inhibit the adenosine-driven impairment of tumor-infiltrating lymphocytes (mainly T cells and NK cells) and myeloid cells (dendritic cells, macrophages), mediated by A2a receptor and A2b receptor, respectively. A2b is also upregulated in certain tumors, such as in KRAS-mutated cancers. As a result, AB928 may uniquely block adenosines immunosuppressive and cancer cell-intrinsic effects. Developed specifically for the oncology setting, AB928 achieves high penetration of tumor tissue, robust potency in the presence of high adenosine concentrations, and minimal shift in potency from non-specific plasma protein binding. AB928 has demonstrated a favorable safety profile with a variety of combination regimens and exhibits pharmacokinetics / pharmacodynamics consistent with once-daily dosing. AB928 is currently being evaluated in several Phase 1b/2 studies across multiple indications.

About the Taiho Agreement

Arcus and Taiho entered into an option and license agreement in September 2017 pursuant to which Arcus granted Taiho an exclusive option, over a five-year period, to in-license the development and commercialization rights to clinical-stage product candidates from Arcuss portfolio for Japan and certain other territories in Asia (excluding China). Taiho is obligated to pay an option exercise payment for each option exercise, with the amount dependent on the development stage of the applicable Arcus program for which the option is exercised. In addition, Taiho is obligated to pay to Arcus clinical, regulatory and commercialization milestones of up to $275 million per program as well as royalties on net sales in Taihos territories.

About Arcus Biosciences

Arcus Biosciences is an oncology-focused biopharmaceutical company leveraging its deep cross-disciplinary expertise to discover highly differentiated therapies and to develop a broad portfolio of novel combinations addressing significant unmet needs. AB928, the first and only dual A2a/A2b adenosine receptor antagonist in the clinic, is being evaluated in several Phase 1b/2 studies across multiple indications, including prostate, colorectal, non-small cell lung, pancreatic, triple negative breast and renal cell cancers. AB680, the first CD73 small-molecule inhibitor in the clinic, is in Phase 1/1b development for the treatment of first-line metastatic pancreatic cancer. AB154, an anti-TIGIT monoclonal antibody, is in randomized Phase 2 development for the treatment of first-line metastatic non-small cell lung cancer in combination with zimberelimab and AB928. Zimberelimab (AB122), Arcuss anti-PD1 monoclonal antibody, is being evaluated in a Phase 1b study as monotherapy for cancers with no approved anti-PD1 treatment options, as well as in combinations across the portfolio. For more information about Arcus Biosciences, please visit http://www.arcusbio.com.

About Taiho Pharmaceutical

Taiho Pharmaceutical, a subsidiary of Otsuka Holdings Co., Ltd., is an R&D-driven specialty pharma focusing on the three fields of oncology, allergy and immunology, and urology. Its corporate philosophy takes the form of a pledge: We strive to improve human health and contribute to a society enriched by smiles. In the field of oncology in particular, Taiho Pharmaceutical is known as a leading company in Japan for developing innovative medicines for the treatment of cancer, a reputation that is rapidly expanding through their extensive global R&D efforts. In areas other than oncology, as well, the company creates and markets quality products that effectively treat medical conditions and can help improve people's quality of life. Always putting customers first, Taiho Pharmaceutical also aims to offer consumer healthcare products that support people's efforts to lead fulfilling and rewarding lives. For more information about Taiho Pharmaceutical, please visit: https://www.taiho.co.jp/en/.

Forward-Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical facts contained herein, including, but not limited to, any potential benefits from Taihos option exercise of zimberelimab and the timing of any data or other anticipated milestones in Arcuss clinical trials, are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All forward-looking statements involve known and unknown risks, uncertainties and other important factors that may cause Arcuss actual results, performance or achievements to differ significantly from those expressed or implied. Factors that could cause or contribute to such differences include, but are not limited to, the inherent uncertainty associated with pharmaceutical product development and clinical trials, delays in clinical trials due to difficulties or delays in the regulatory process, enrolling subjects or manufacturing or supplying product for such clinical trials, the emergence of adverse events or other undesirable side effects, and changes in the competitive landscape for our programs. Risks and uncertainties facing Arcus are described more fully in Arcuss quarterly report on Form 10-Q for the quarter ended September 30, 2019 filed on November 5, 2019 with the SEC. You are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date of this press release. Arcus disclaims any obligation or undertaking to update, supplement or revise any forward-looking statements contained in this press release.

Source: Arcus Biosciences

View source version on businesswire.com: https://www.businesswire.com/news/home/20200226005249/en/

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Have you ever thought about how many times you train in a gym? If you've squatted once a week for two years in a conventional 3x10 rep scheme, you've squatted in a gym nearly five thousand times.

Sounds boring.

The reversibility of training effect drives many of us to stay consistent in our training. Stop training and you get weaker, keep going and you at least stay the same. Successful athletes train the longest. The challenge arises when potential progress is overshadowed by the apathy that comes with going to the same place to do the same exercises in the same order until the end of time.

Below we've pulled together a few methods to avoid boredom at the gym. These aren't prescriptive- just tools to get your creative juices flowing when you're just not feeling like training.

ACTION: Download a timing app on your phone or invest in a stopwatch to ensure that you are always on the ball with your rest periods.

WHY: Rest intervals dictate the quality of the training set, and adherence to them can keep you focused during training while also helping you see improved results.

ACTION: Choose wisely here, as finding someone who truly supports your training can reap impressive rewards. Not only will they spot you during maximal sets but if you pick the right person, they'll help you with Method 1 by telling you to shut up once in a while and get back to work.

WHY: This article outlines the benefits of having a spotter during the Bench Press. This can easily be extrapolated out to apply to other exercises. Improved performance simply by having a buddy around should not be ignored.

ACTION: Use a four-week training block.

WHY: Long programs are hard for everybody. They're hard to write from a coach's perspective and hard to adhere to from a training perspective. Using four-week training blocks can provide the glorious feelings of starting and finishing a training block more frequently. Everybody tries hard during the first and last few weeks of a training program.

ACTION: Remove the headphones.

WHY: Always listening to music while training can lead someone to feel alone at the gym. If you've never heard yourself breathe hard due to the Metallica crushing your stereocilia, take the Beats off for a training session and get in touch with your training environment.

ACTION: Reverse Anti-Boredom Method 4.

WHY: If you always train with the sound of strangers' breathing filling your ears, take a walk on the wild side and see if Kelly Clarkson can't re-motivate your training sessions.

ACTION: I get it, attending group fitness can sound like a death sentence. A generic program for you? After all the attention you spend on your training? What a ridiculous idea.

WHY: Adam Virgile, a sport scientist formerly with the New York Rangers and now teaching at the University of Vermont, talks about a study showing improved motivation to exercise with no negative effects toward muscle size or strength when introducing exercise variation into a training program. You can find it here.

Group fitness can pay dividends by introducing exercise variation into your program, helping you with tightening up rest periods without individual effort. It also surrounds you with some new people who are, from experience, extremely high energy. If you don't like an exercise in a given class, ask for a substitution. Group fitness instructors love when people who are serious about their training attend their classes.

ACTION: Try out a few "free assessment" days or ask friends for referrals.

WHY: A personal trainer provides an assessment, program and accountability to you. Having someone write your program for you can take the guesswork out and allow you to just train and have fun! As a personal trainer I train a number of other personal trainers for exactly this reason.

Even if you are an accomplished program writer, constantly doing your own programs can lead to a lack of adherence, a "blinder" effect to new training concepts and above all, boredom.

ACTION: Same as Method 7 with new people!

WHY: If you're finding yourself bored with a program, provide that feedback to your trainer and see if there are any adjustments made. If not, then they aren't listening to you anyway.

This method should be used as a last resort, as for the most part personal trainers do a great job switching up their programming and keeping clientele involved.

Go find yourself a good one! They're all over the place.

These eight methods to avoid boredom at the gym are tools to get your creative juices flowing. When you're just not feeling your training program, remember it's not a sprint- Successful athletes train the longest.

Regardless of the training program that you're on, the success you find within the gym will be directly related to your ability to stay in it. If boredom is crushing your heart and soul as you drive yourself to the gym after a long day of work or particular short bout of sleep, try some of these methods to rejuvenate your training.

Photo Credit: aldarinho/iStock

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'Wellness' programs are more popular than ever. They're ineffective at best, harmful at worst.

At the hospital where Christina works as a physical therapist, she and her coworkers are routinely shuffled into a big conference room and measured for waist size and BMI, blood pressure and blood sugar.

If their measurements arent low enough according to the companys parameters they pay extra each month. If they pass two of the three categories, they pay less.

When I did it this year, I fasted before so my blood sugar wouldnt be high, said Christina, who asked that we change her name.

I was so nervous about some random dude measuring my waist and telling me Im too fat.

At the media company where Molly works, theres an eight-week annual wellness program, centered around either exercise or weight loss.

While its technically optional, completing the program saves her $800 annually on insurance a significant amount of money to her that doesnt feel optional. Mollys name has also been changed for this story.

Its been 12 years since The Office depicted a workplace-wide weight loss program, but the programs are more popular than ever.

In 2020, theyre titled wellness programs, though the focus is often still on weight. About 90 percent of large workplaces have them.

Theres a reason for that. In 2014, the Affordable Care Act incentivized such programs, allowing employers to raise premiums as much as 30 percent for folks who dont reach certain benchmarks.

These programs are often well-intentioned. But theres evidence that theyre not all that effective.

A 2016 study found that incentive-based wellness programs lead to virtually no change in weight.

Other studies have found no significant improvements in self-reported measures of health like sleep quality, other clinical measures of health, such as cholesterol and blood pressure, or workplace outcomes, like job performance.

[ICYMI: Fake Food Science is Everywhere. These Influencers are Trying to Stop it.]

Wellness comes with risk

And while theyre often hailed as cost-saving measures, most companies dont even save any money on healthcare outcomes.

Instead, studies show workplace wellness programs lead to increased weight stigma and discrimination in the office, leaving folks feeling alienated and uncomfortable, and even less likely to believe their weight is in their control.

Weight stigma is real. Fat people are more likely to be seen as lazy and unprofessional. Surveys of recruiters indicate fat job applicants are seen as less hireable than thin candidates.

Credit: AdobeApproximately 30 million Americans suffer from an eating disorder, and eating disorders are the mental illness with the highest mortality rate.

Weight stigma can also lead to poorer medical care for fat folks and subsequently worse health outcomes.

This focus on weight in the office can also be dangerous for folks who are at risk of or personally affected by eating disorders.

We know that dieting and restricting is a major risk factor for the development of disordered eating and full-blown eating disorders, said Claire Mysko, CEO of the National Eating Disorders Association.

So when theres a focus on weight loss specifically, thats already a risk.

Disordered eating is widespread and deadly. One survey from SELF found that 65 percent of American women between the ages of 25 and 45 have disordered eating behaviors.

According to the National Association of Anorexia Nervosa and Associated Disorders, 30 million Americans suffer from an eating disorder, and eating disorders are the mental illness with the highest mortality rate.

Only 40 percent of folks with eating disorders fully recover.

Taking weight out of the picture

Initially, many workplace wellness programs showed up as Biggest Loser-style competitions, modeled after the popular NBC TV show, pitting employees against each other to see who could lose more weight.

But today, in an era where body positivity has gone mainstream, the messaging is more subtle, packaged under wellness, a buzzword of sorts. Instead of obsessing over thinness, these programs often obsess over fitness with weight loss still as an indicator of success.

Were at a place and time where there are so many mixed messages about what it means to be healthy, Mysko said.

Wellness as an industry, at its core, still equates thinness with health, and weight loss as always good. Mysko said thats dangerous for folks who are predisposed to eating disorders.

For instance, Weight Watchers, the popular diet company that rebranded as WW last year, calls itself a campaign for wellness on the front page of its website. Meanwhile, its still a diet company, with weight loss as primary goal for its customers.

Mysko said health initiatives arent inherently bad. Exercise is healthy. But instead of running programs that focus on weight, she recommends that companies take a more holistic approach.

That means no competitions or weigh-ins, and no focus on weight loss or weight management.

When we talk about health, were also talking about mental health, she said.

Taking the emphasis away from weight and BMI, and helping people to adopt habits that are supporting all aspects of their health.

Eating disorders dont exist in a vacuum theyre tied to other mental health conditions, like depression and anxiety.

But even as weight loss is a common conversation topic, mental health in the workplace still feels taboo.

Ignoring mental health also comes with a cost between $80 and $100 billion annually, according to Forbes. And its incredibly common, with one in five adults experiencing mental illness each year.

NEDA recommends talking to your HR department if youre concerned about your workplace wellness program.

By Gretchen Brown

Gretchen is an editor for Rewire. Shes into public media, music and really good coffee. Email her at gbrown@rewire.org, or follow her on Twitter @gretch_brown.

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