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When trying to lose weight it can be tempting to drastically cut certain foods your diet plan. While removing unhealthy foods can speed up weight loss, eating more of the right foods can actually give the best results. Having a diet high in protein can speed up weight loss, an expert explained.

It can be tempting to eat less when trying to lose a few pounds but this does not necessarily work.

Tucking into foods high in protein could give the best results, Elliott Upton, personal trainer at Ultimate Performance and Head of LiveUP Online Coaching, said.

He told Express.co.uk: Every meal should be built around a quality source of protein.

It helps to repair, rebuild and maintain muscle tissue, which not only improves body composition - the way your body looks - but also increases metabolic rate.

READ MORE: Gordon Ramsay: How did he shed 3st? TV chef on heartbreaking motivation for weight loss

Speeding up the metabolism makes the body burn more calories which leads to fat loss.

As well as burning fat more quickly, high protein foods reduce hunger so slimmers will probably eat less overall.

Elliot added: It is also satiating, so helps keep you fuller for longer, and the better you can control hunger, the more sustainable your diet will be.

High protein foods include meat, fish, dairy products, nuts, tofu and beans.

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Ultimately, the best diet is going to be one that is easy to stick to, the expert explained.

He added: There is no best diet or perfect diet to follow.

However, there is a best diet for you, that is always going to be the one that best fits your lifestyle and one that is going to be the most sustainable.

There is nothing overly complicated about dieting the challenging part is adhering to it consistently and long enough to see results.

Following a healthy diet plan can be paired with regular exercise for a weight loss transformation.

Elliot said full body compound exercises and resistance training are the best for burning fat.

Resistance training is the number one tool we use for weight loss and body composition change, alongside nutrition, the expert suggested.

Lifting weights helps to build muscle, lose fat and increase your metabolic rate.

The reason weight training is so efficient for fat loss is that there are so many variables we can change within the same one hour workout to keep challenging the body and progressing through progressive overload.

Some of the variables we can change are: reps, sets, weight, tempo or total time under tension, range of motion, rest, angles, machines vs. free weights, etc.

"This constant manipulation to key variables is the advantage weight training has over traditional cardio, where you essentially need to run further, longer, faster or more frequently to keep progressing and losing weight."

He explained compound exercises can help burn more calories than simply doing cardio.

Pairing exercise and diet can give the best results when trying to get into shape.

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Weight loss diet plan: The one food you should eat more of to help burn belly fat fast - Express

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Slices of raw yellowtail fish. Fuumi901/ Shutterstock

When most people think of the paleo diet, they picture a simple, back-to-basics eating style full of real food like grass-fed meats, sustainable seafood, and some fruits, veggies, seeds, and nuts.

What they don't imagine is a bunch of toxic metals, including lead and mercury but that's exactly what researchers found in a new study on the seafood diet of early humans in Norway, published January 28 in Quaternary International.

Researchers from the Arctic University of Norway and Stockholm University looked at 40 samples of skeleton remains of Atlantic cod and harp seal, both food sources for prehistoric humans, from eight archaeological sites in a region called Varanger in northeastern Norway. The bones were between 3,800 to 6,200 years old, representing a period of the Stone Age where humans in that region ate mostly seafood, along with some reindeer, beaver, hare, and occasionally some species of birds.

They found that evidence that both species contained toxic heavy metals cadmium and lead, in dangerous quantities. The amount of cadmium was between 15-22 times higher than what today considered safe for human consumption; the amount of lead was between three and four times higher than considered safe.

Researchers also found elevated levels of mercury, another toxic heavy metal, although not beyond what is currently regarded as safe.

All three types of heavy metals found in the seafood remnants are linked to human health issues. Exposure to cadmium can cause kidney, bone, and liver problems, while both lead and mercury can cause brain damage and even death, according to the Centers for Disease Control and Prevention (CDC).

Researchers concluded, based on these findings, that "marine food during the Younger Stone Age in Varanger was unhealthy if not unsafe," according to the study.

However, it's not clear from the data in this study what the health effects of eating contaminated seafood may have been, or even if our Stone Age ancestors lived long enough to suffer the side effects of the toxins.

In trying to account for these results, researchers found a correlation between the surprisingly high levels of toxins and markers of climate change such as sea surface temperature and shoreline levels. They found that the higher levels of metals, at least in Atlantic cod, were linked to rising sea levels and sea temperatures, potentially due to erosion and/or volcanic activity.

However, this study was relatively small, so more research is needed, across more bone samples and a broader region, to better understand how changing temperatures and rising seas may have affected our ancestors' food sources and health.

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The original paleo diet included seafood with 22 times the safe limit of toxic metals, study finds - Insider - INSIDER

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Subject to grueling hours and intense political pressure, Japans elite bureaucrats are beginning to ask themselves whether its all worth it. Political scientist Nonaka Naoto traces the growing crisis to deeply entrenched legislative procedures rooted in de facto one-party rule.

Japanese democracy observed a milestone in October 2019, when the National Diet convened for its 200th session. Unfortunately, the two-month extraordinary session was dominated by opposition grilling over government scandals and bureaucratic malfeasance, leaving important policy issues on the back burner.

The Diet session also called attention to the extraordinary pressures that are causing young bureaucratsand those contemplating such a careerto question whether the benefits of a job in government are worth the costs. Even with a massive typhoon approaching Tokyo, civil servants remained holed up in their offices in Kasumigaseki, frantically preparing their ministers responses to questions from opposition politicians.

The problems afflicting Japans legislative and administrative branches are structurally related. In the following, I would like to trace their origins and clarify their connections in an effort to light the way to a solution.

At one time, the Japanese bureaucracy was regarded as a model of organizational autonomy, technical expertise, and policy leadership. Today, it is more often associated with the phenomenon of sontaku, the apparent willingness of senior administrators to cast aside ethical standards in their rush to curry favor with the prime minister and his cronies. To understand this transformation, we need to examine the changing relationship between the administrative and political spheres in the period since 1955, when the Liberal Democratic Party came to power.

The first and most obvious aspect of this relationship is the system of collaboration that developed between the bureaucracy and the ruling LDP under the so-called 1955 system, which persisted until 1993. The key institutional component of this relationship was the LDP Policy Research Council, whose organization mirrored that of the governments administrative apparatus. The tribes of LDP lawmakers, or zoku giin, appointed to each division of the Policy Research Council lobbied on behalf of specific industries and other interests, serving as a link between those interests and the government agencies with jurisdiction over them. Although bureaucrats of each ministry took the lead in the process of crafting policy and drafting laws, all legislation had to be vetted and approved by the relevant committees of the Policy Research Council before the cabinet could submit it to the Diet. This close collaborative relationship made use of the abilities of Japans elite, highly educated bureaucrats while upholding the democratic principles of the postwar Constitution, under which the democratically elected Diet is the highest organ of the state. It was the price the bureaucracy paid for maintaining its influence.

But the principles of postwar democracy also insisted that the minority parties have a voice in government policy. With no prospect of wresting the reins of government from the LDP, the opposition asserted itself largely through Diet questioning, in which lawmakers grilled cabinet members, who in turn relied on the expertise of the civil service for their responses. Thus, while negotiating and coordinating with the LDP outside of the Diet, Japanese bureaucrats were also obliged to fence with the opposition during legislative sessions. In this sense, the power of Japans postwar bureaucracy during the 1955 setupunlike that of the prewar erawas carefully circumscribed and subject to constraints from the elected politicians of LDP and the opposition alike.

However, the balance began to shift decisively during the turbulent 1990s, as the government decision-making apparatus came under mounting criticism for corruption, sectionalism, and inefficiency. Beginning in the mid-1990s, with the cabinet of Prime Minister Hashimoto Rytar, successive governments enacted a series of far-reaching administrative and civil-service reforms designed to strengthen "political leadership" in the form of top-down, centralized control over the bureaucracy and the policymaking process. The Cabinet Office, headed by the chief cabinet secretary and the prime minister, was given the resources and authority to formulate and coordinate basic policy. These top politicians established completely new types of advisory councils consisting of both government and private-sector experts to draw up recommendations for legislation and other policy measures.

Last but not least, the prime minister and the chief cabinet secretary were given centralized control over the appointment and management of senior administrative personnela change of momentous importance for the autonomy of Japans civil servants and their relationship with the political sector.

Ministries and agencies were stripped of their former organizational autonomy. Now the fate of officials hung on the good opinion of the prime minister and chief cabinet secretary, who had the power not only to block appointments but also to deprive senior officials of authority and prestige simply by denying them a place on a policy council. The reforms dramatically weakened the clout of the bureaucracy, as well as its symbiotic relationship with the LDP, and placed Japans administrators in a position of absolute subservience to the prime ministers office.

At the same time, the bureaucracys relationship with opposition politicians remained fundamentally unchanged. Civil servants still find themselves in the firing line during the oppositions relentless and often hostile questioning in the Diet. In fact, Diet interaction between opposition politicians and civil servants has grown all the more fraught now that the latter are manifestly working for the prime minister and his cabinet.

In this sense, the current crisis facing Japans civil service relates directly to legislative procedures and systems that have taken hold in the Diet since the LDP took power in 1955. Nor is this the only consequence of the Diets peculiarities. Of course, the rules and customs governing parliamentary government vary from one country to the next, but there is no denying that Japans National Diet is among the most peculiar legislative assemblies in the advanced industrial world because of the unique pattern of parliamentary rationalization in postwar Japan.

The first peculiarity is the way that plenary sittings have been relegated to the status of a rubber stamp as Diet committees have taken over the deliberative process. This is especially evident in the small amount of time allotted to itroughly 60 hours a year on average (in the House of Representatives). That is about one-twentieth of the time spent in Britain and France.

Almost all national legislatures feature a combination of committee and plenary deliberation, but in most countries the two play complementary roles in the legislative process. As a rule, the committees are tasked with gathering and evaluating technical information and ironing out differences in a collaborative spirit, while the plenary deliberations are the stage for impassioned partisan debate. In postwar Japan, this basic model has broken down. The plenary sessions have become pro forma, and the committees have taken over as the main arena for partisan posturing. As a result, the committees no longer perform their original legislative function, nor can they be expected to.

The second peculiarity is the inordinate amount of time devoted to question-and-answer sessions (shitsugi), as opposed to parliamentary debate. The difference is twofold. First, debate is a free exchange of views, while questioning is limited to specific queries prepared and submitted in advance. Second, debate typically takes place between legislators, while questioning (in Japan, at least), consists primarily of hostile questions posed by opposition politicians to cabinet ministerswho in turn may call on bureaucrats or private-sector experts to assist in delivering their response. This is partly because almost all the bills put before the Diet are government-sponsored bills, but it also reflects the oppositions use of questioning to highlight real or alleged government misconduct. In either case, the questions are submitted in advance, and bureaucrats are given the thankless and time-consuming task of assembling the data and talking points needed to respond. (They are frequently required to appear in person as well.)

This question-and-answer format, which took hold during the years when the LDP was firmly ensconced as the perennial ruling party, lies at the heart of many of the systemic problems plaguing Diet deliberations. But any effort to change it meets fierce resistance, since it is the single most important institutional weapon at the disposal of an opposition with no prospects for winning an electoral majority.

Even more troubling is the third peculiarity of Diet deliberation: the fact that members of the ruling LDP play almost no part in it. Of course, the LDP accumulated great policymaking clout under the 1955 system, but it wielded that power almost exclusively through extra-parliamentary channels. In fact, the backroom negotiations of the Policy Research Council divisions have eliminated open Diet deliberation for LDP legislators.

Currently, almost 70% of the time set aside for Diet questioning is allocated to the minority parties. While the opposition uses its time for ruthless interrogation, politicians of the ruling party seem to view their meager allotment as a burden. The result is that on average, contribution of LDP politicians to committee deliberation is a mere 5% of that from members of the Communist Party. In short, the role of LDP Diet members is simply to vote on the government-sponsored bills put before themlegislation that has already been vetted, revised, and approved by the party brass. The system simply leaves no room for serious deliberation or debate either in committee or in plenary sittings.

To review, the postwar Diet evolved as a body in which the ruling and opposition parties played their assigned roles, while the bureaucracy took the leading role in the process of formulating policy and drawing up legislation. The LDP, for all its attention to form and procedure, ceased to be an active or meaningful participant in the Diet, as the opposition took center stage. Moreover, it was the bureaucrats who were left to cope with the oppositions grilling.

By correcting the overcentralization of administrative power in the office of the prime minister, it might be possible to create a healthier balance between our politicians and bureaucrats. This would help address the problem of sontaku and mitigate some of the pressures under which our civil servants are obliged to operate. But the problem of overworked, overstressed bureaucrats is inextricably tied to Japans dysfunctional Diet. And Diet reform is a difficult task requiring insightful and decisive political leadership.

As I have stressed, the context in which the Dietspeculiar and anomalous workings evolved was the LDPs monopolistic control of government. Despite the electoral reforms that helped sweep the LDP from power in 2009, a viable two-party system has yet to take hold in Japan. Under the circumstances, it is will be no easy matter to fundamentally change the way the Diet works. But we can start by understanding the origins of the problem and carefully studying the options for reform.

(Originally published in Japanese. Banner photo: Prime Minister Abe Shinz responds to questions from Diet members in the House of Representatives, October 8, 2019. Jiji.)

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Untying the Knot of Japan's Bureaucratic and Diet Dysfunction - Nippon.com

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In the summer of 2018, Olympic legend Mark Spitz walked to his fridge and almost fainted. His wife called the paramedics, kicking off a harrowing 12 hours at his local hospital.

The incident came out of nowhere. No one was as surprised as Spitz, who, at 70 years old, is still in damn good shape, exercises regularly, and has eaten a low-meat diet for almost 20 years. So what happened?

It turns out Spitz has atrial fibrillation, more commonly known as AFib. Its a condition where the heart beats erraticallyeither too fast (tachycardia), as it does for Spitz, or too slow (bradycardia). Curiously, its relatively common among elite athletes as they age. And in case you need a refresher about Spitzs elite athlete status: In 1972, he won seven gold medals and set seven world records at the Munich Olympics, all while rocking one of the finest mustaches of the 20th century.

Spitz has made a full recovery since his scare in the summer of 2018so much so that hes enthusiastically partnered with AliveCor, which manufactures the portable EKG monitor he now endorses (KardiaMobile). He recently spoke to GQ about living with a chronic heart condition, swimming imaginary races against Michael Phelps in his backyard pool, how training for the Olympics has evolved in the half-century since he competed, and who to watch for in Tokyo this year.

GQ: Can you tell me how you came to be diagnosed with AFib?

Mark Spitz: Well, it was a Sunday I believe, and my wife asked me to grab some blueberries from the refrigerator. When I got out there, I was feeling kind of weird, like light-headed, and I said to my wife, I think Im going to faint. And I dont ever get that sensation. After about five minutes, my wife called the paramedics.

The next 12 hours, they were trying to control me with medication. They had an IV in one arm for blood thinners, and another IV for controlling adrenaline to get my heart rate down. It was coming down but not fast enough, and they thought they could actually shock me into sinus rhythm. I was put to sleep and they shocked me three times in two minutes, like you see in the movies with the paddles. It still didnt go down until later that evening.

Id imagine that was a scary time.

Oh yeah. The disturbing thing I found out is that this stuff doesnt go away. Its not like, Take two Aspirin and call me tomorrow. This is a lifetime experience.

What kinds of lifestyle changes did you make to deal with that?

Having AFib is not a question of changing your lifestyle, its a question of understanding your lifestyle. If in fact you have some bad habits, you have to arrest those. There are three major things that my doctor says you should take into account: monitoring, diet, and exercise.

I have to be able to track my heart activity. A lot of people dont know that theyre in AFib, and a lot of people dont like to go to the doctorwhen you have an EKG, they hook up all these wires to you, and youre afraid of what theyre going to find out. But if you go into a routine of taking your EKG, then it just becomes a standard thing. I think knowing is so much more important than being afraid and not knowing.

I use this device called KardiaMobile. [Spitz is a spokesperson for KardiaMobile.] It can actually create an EKG at any time in 30 seconds. So Im constantly monitoring myself.

Excerpt from:
Mark Spitz: The Real-Life Diet of the Legendary Swimmer Who Still Does Imaginary Races Against Michael Phelps - GQ

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New research shows that if you adapt what you eat as you grow older, you can prevent weight gain, muscle loss and a host of chronic diseases before they begin. Consider this your new cribs sheet to graduating from your care-free twenties to the proper dietary 'adulting' of your thirties.

Once you pass this threshold, your metabolism starts to slow and so increases your risk of weight gain and muscle loss. It's hardly ideal. Add to the mix that it'll time to start thinking about your risk of heart disease and things can become a little taxing once you pass the big three-oh.

Cue the numerous health benefits of Omega-3 fatty acids. Think salmon, mackerel, oysters, tuna, trout and even some white fish like pollock and perch. Each can all deliver a nutritional payload, loaded with good fats that can help lower your risk of heart disease and up your muscle-building macros in one fell swoop.

But, what's the science? Well, dieticians say you should eat at least two 4-ounce portions of fish weekly. And look, you don't have to cook it. Try canned salmon or tinned sardines. All you need is a bed of greens or a bowl of rice to make it a meal. Who needs Joe Wicks?

If you're vegan, chia seeds, flax seeds and walnuts are also a great source of Omega-3. Vegan supplements also exist you neednt rely on fish oil capsules when youre looking to top up your levels of this health-boosting nutrient.

Vegan Omega 3 Softgels

16.99

Protein will also help to keep your metabolism fired up as you move into your fourth decade. It has a high thermic effect as it is digested, which means that it requires more energy to be broken down. Following a high protein diet can help you to burn between 80 and 100 extra calories a day.

There's one habit to try and break, though: binge drinking. From 2009 to 2016, the average annual increase in deaths from cirrhosis was highest in people aged 25 to 34, according to a 2018 study published in BMJ. Repeatedly subjecting your liver to five drinks in two hours how the National Institute on Alcohol Abuse and Alcoholism defines a binge may lead to liver damage. Go easy.

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This Simple Diet Tweak Will Help You Burn Fat and Beat Heart Disease in Your 30s - Men's health UK

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In January, Oprah Winfrey launched her nine-city tour called "Oprah's 2020 Vision: Your Life in Focus" as a way to motivate and inspire fans to live their healthiest and most fulfilled lives.

"How do you take this energy of inspiration and people feeling triumphant in their lives? How do you use that to something that's a greater good than just my front porch?" Oprah asked guests at her first tour stop in Fort Lauderdale, Florida, Entertainment Tonight reported. "And that's how this idea came about. I'll try to spread that word around the country."

The tour, which is in partnership with weight-loss program Weight Watchers (now known as WW), will also run in cities like Dallas, Texas; San Francisco, California; and Los Angeles, California, with guests including Michelle Obama, Jennifer Lopez, Gayle King, and Tina Fey.

Oprah's mission to teach people how to live their best and healthiest lives is at the core of both her tour and personal brand, but this is hardly her first foray into the topic. The former talk show host has interviewed celebrities on everything from vaccines to youth-enhancing remedies, and discussed her own health practices like meditation and healthy eating.

Here are the best and worst health tips Oprah has talked about over the years.

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Oprah's best and worst health advice from almost 5 decades as a talk show host and trend-setter - Insider - INSIDER

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Happy Thursday MarketWatchers. Dont miss these top stories:

Barrons wants to recognize people and organizations whose products, services, or education programs are making an impact to improve the financial health of individuals across the U.S. Be sure to head to barrons.com/celebrates for more information and to submit a nomination by Feb. 29 for the Barrons Celebrates: Financial Empowerment program.

Significant expenses for one family member may adversely affect the whole family.

IRS audits have been sliding for years as the federal tax collectors staffing has been reduced.

There are several deferments and forbearances that can temporarily suspend the obligation to repay federal student loans.

Researchers evaluated the coronary health of 760 women over a decade to figure out how what we eat affects our heart health.

Department officials say the new rules help students, and also save taxpayers money.

Disney increased the prices of some tickets and passes for its theme parks in California and Florida.

Implementing systemic change like Medicare for All, the plan championed by 2020 Democratic frontrunner Sen. Bernie Sanders, sits lower on the list.

She tries to curb my outside activities, and basically wants me to bend to her will on anything and everything.

For the last few months, Ive been working two part-time jobs in addition to my military duties to save up for my monthly shortfall while Im in school.

The number of pages will probably be in the thousands of pages.

Roger Stone, a longtime associate of President Donald Trump, on Thursday was sentenced to 40 months in prison after being convicted of lying to Congress, witness tampering and obstruction.

The odds of an economic downturn in the this year remain low, which means that President Donald Trumps prospects for re-election in November are strong. But he remains his own worst enemy, writes Michael Boskin.

Governments must urgently adopt effective global health diplomacy to stem the growing global panic caused by the coronavirus outbreak.

Burger King announces it is removing artificial preservatives from its most famous burger.

Young and old each have their advantages, but the combination of both is best for solving problems.

The economy showed some more sizzle at the start of 2020, pointing to steady growth in the next several months, according to an index that measures the nations economic health. The leading economic index jumped 0.8% in January.

Do you believe the world will embrace a green path toward the future? If so, you might want to consider slapping a palladium position next to your Tesla shares in your portfolio, according to the investor behind the Market Ear blog.

Thursdays stock-market swoon could be down to traders finally realizing that the coronavirus impact could be more lasting than thought.

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Why the IRS might soon be ringing your doorbell and this diet will help reduce your risk of heart disease, scientists say - MarketWatch

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Menopause is the phase that brings huge change in a woman's life. It marks the end of her menstrual cycles and fertility, which is confirmed 12 months after the last period she has. Cessation of menstruation is associated with several symptoms - weight gain, mood fluctuation, vaginal dryness, headache etc. The fluctuation of hormones (particularly the decline in oestrogen and progesterone) is to be blamed for most of the menopause complaints. A recent study has suggested that a healthy diet, rich in fruits and vegetables, may help in lessening several menopausal symptoms. This study was published in the Menopause: The Journal of the North American Menopause Society.

As per the study, it has focused on identifying modifiable lifestyle factors to prevent menopausal symptoms. However, hormone therapy has been proven to be an acceptable method for menopausal symptoms; rather the search for nonpharmacological treatmentoptions is ongoing, especially for women with certain risk factors and those who are not candidates for hormone therapy.

"This small cross-sectional study provides some preliminary evidence regarding the influence of fruit and vegetable intake on menopause symptoms," said study researcher Stephanie Faubion from The North American Menopause Society (NAMS) in the US, as per an IANS report.

Previous studies suggested that consumption of fruits and Mediterranean-style diet were linked to decrease of menopausal complaints. Taking this a step ahead, the new study found 'an apple a day might help keep menopause symptoms away'.

Researchers also stated that though several fruits and veggies had inverse association with menopause symptoms, higher intake of several other kinds of fruits (like citrus fruits) and vegetables were associated to more urogenital problems.

"There is ample evidence that a healthy diet rich in fruits and vegetables has a beneficial effect on health in a myriad of ways, but additional study is needed to determine whether various menopause symptoms may be affected by dietary choices," Faubion concluded.

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Diet With Higher Fruit And Veggies Intake Linked To Fewer Menopausal Symptoms - Study - NDTV Food

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Recent sightings of whitetail bucks that are still carrying antlers in mid-February have gotten my attention.

If I had a dollar for every time Ive heard that bucks will shed their antlers early if the winter starts out miserable and cold, then Id be able to start a recovery fund of moneyto put our kids throughcollege. That said, when it comes to bucks shedding antlers, I admit, Im no biologist. Ive always believed nutrition, water and climate affectwhen bucks would start losing their antlers. And when others share theories with me about this, I usually just listen, add their thoughts to my own, and just move on to the next thing.

Butwhen my pal Vicky Griswold from Colrain sent me a picture of a mature buck still carrying a full set of horns on Feb. 5, I began to question these theories of when and why bucks drop their antlers. After confirming some things I already knew, I began uncovering facts that enlightened me about this wonder of when and why whitetail bucks shed their antlers. And as you read on, you may find yourself enlightened as well.

Antler development is dependent on photoperiod (hours of daylight per day) and testosterone levels, not necessarily temperatures. Antler drop is also dependent on these same principles. High levels of testosterone are necessary to keep a bucks antlers firmly attached to his skull. When testosterone levels drop, antlers loosen and begin to shed. Some wildlife biologists take it a step further, sayingthat testosterone levels are affected not only by photoperiod, but also poor nutrition, injuries and dominance.Testosterone levels are also affected by the presence of does that are in estrus. In Massachusetts, most does are bred between mid tolate November, but if unbred does are present, bucks will keep their antlers longer. Another factor is continued fighting between bucks, which could be related to additional does in estrus. If bucks continue to spar late into the winter, testosterone levels stay up, thus their antlers will stay on longer. And thats something that just never occurred to me in over 50 years of studying and chasing whitetail deer.

Trying to really explain this to someone requires a good understanding of the antler cycle itself, as whitetail deer are distributed all over the United States with varying climates playing a role at the beginning of this cycle every year. In temperate zones, antler growth commences with increasing daylight in the spring, and with that comes the corresponding rise of breeding hormones. Antlers are initially covered in velvet and laced with blood vessels. By mid-to-late summer, the antlers have begun to harden, or calcify. Blood flow declines and finally stops, and the velvet peels away quickly often aided by a buck scraping his antlers against fence posts, shrubs or trees as summer progresses into autumn.

By late October, antlers are fully hardened and bare for the rut season, when bucks begin establishing breeding dominance. The timing of antler drop commences with diminishing daylight and falling hormones after the height of the breeding season. Antlers begin to weaken when special cells called osteoclasts that live at the base, or pedicle, of the antler reabsorb its calcium. Eventually the antler drops, leaving a bloody pedicle that quickly heals over. Antlers dont always shed at the same time, and bucks with one antler are not uncommon sights in winter, especially in the Northern tier(s) of the country. But in the Upper Midwest, bucks may begin dropping antlers in early December, while their Florida or Gulf Coast counterparts may retain them and remain in rut into mid-winter or later because of the drastic change in latitude of those regions. However, weakened bucks will shed their antlers much earlier, just like anywhere else.

Regarding Vickys picture, I believe the excellent acorn crop we experienced this past year might have helped with this bucks health and antler development, adding those important, special nutrients to their diet. Thats just another theory, however, a week later, Vicky sent me another picture of a smaller buck looking just as healthy and, you guessed it, still carrying a set of tall spikes in the middle of February. That certainly leaves us with something more to think about.

Lastly, heres a breakdown I thought you might find interesting of the final statewide deer harvest totals (by zone) for 2019. Note: The 13,921 final tally is the second highest on record,629 less than 2018.

Zone 1 310 total (218 adult males, 84 females, 7 button bucks)

Zone 2 513 total (425 adult males, 79 females, 7 button bucks)

Zone 3 544 total (376 adult males, 148 females, 17 button bucks)

Zone 4N 526 total (389 adult males, 125 females, 12 button bucks)

Zone 4S 312 total (228 adult males, 74 females, 10 button bucks)

Zone 5 702 total (512 adult males, 160 females, 25 button bucks)

Zone 6 206 total (148 adult males, 49 females, 3 button bucks)

Zone 7 733 total (422 adult males, 267 females, 37 button bucks)

Zone 8 853 total (554 adult males, 249 females, 42 button bucks)

Zone 9 1,295 total (690 adult males, 491 females, 105 button bucks)

Zone 10 2,508 total (1,205 adult males, 1,101 females, 192 button bucks)

Zone 11 3,420 total (1,810 adult males, 1,312 females, 287 button bucks)

Zone 12 303 total (193 adult males, 88 females, 10 button bucks)

Zone 13 1,132 total (344 adult males, 629 females, 146 button bucks)

Zone 14 665 total (257 adult males, 315 females, 79 button bucks)

TOTAL 13,921 total (7,772 adult males, 5,171 females, 979 button bucks)

Joe Judd is a lifelong hunter and sportsman. He is an outdoor writer, seminar speaker, member of the New England Outdoor Writers Association, and a 2019 inductee into the N.E. Turkey Hunting Hall of Fame. Joe is also on the Quaker Boy Game Calls, Bass Pro Shops/Cabelas Pro-Staff.

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On the Ridge: Hook 'em Horns - The Recorder

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MedicalResearch.com Interview with:

Robert E. Dudley, Ph.D.Chairman, Chief Executive Officer and PresidentClarus Therapeutics

Dr. Dudley discusses the recent announcement that Clarus Therapeutics, Inc. has launched JATENZO (testosterone undecanoate) capsules for the treatment of appropriate men with testosterone deficiency (hypogonadism):

MedicalResearch.com: What is the background for this announcement?

Response: JATENZOis the first and only oral softgel testosterone undecanoate and the first oral testosterone product approved by the U.S. FDA in more than 60 years.JATENZO is indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone.

The launch of JATENZO means that physicians and men living with testosterone deficiency due to genetic or structural abnormalities finally have a safe and effective oral testosterone replacement therapy. We are proud to commercially launch this unique oral formulation to healthcare providers and the appropriate patients who they treat. JATENZO is now available at pharmacies across the country.

MedicalResearch.com: What are the main findings of the underlying studies?

Response: JATENZO was evaluated in a Phase 3 pivotal trial among 166 adult, hypogonadal men in a 4-month, open-label study with a topical testosterone comparator arm. The starting dose was 237 mg twice daily (BID) with meals. Dose adjustments (minimum 158 mg BID; maximum 396 mg BID) were made roughly 3 and 7 weeks after initiation of JATENZO based on average circulating testosterone concentration levels. 87% of JATENZO patients reached testosterone levels within the normal eugonadal range at the end of the study; peak testosterone levels were in close alignment with FDA targets.

Across all Phase 2 and Phase 3 trials combined, the safety of JATENZO has been evaluated in 569 patients who were treated with JATENZO for up to two (2) years. Liver toxicity was not observed with JATENZO in clinical trials.

Mild gastrointestinal adverse events observed with JATENZO were transient, manageable and did not lead to discontinuation.Decreased HDL cholesterol and increased hematocrit were associated with JATENZO use but did not lead to discontinuation of JATENZO. Only three of the 166 patients (1.8%) in the 4-month study experienced adverse reactions that led to premature discontinuation from the study, including rash (n=1) and headache (n=2). JATENZO was associated with an increase in systolic blood pressure. A boxed warning about the potential risks associated with elevated blood pressure appears on JATENZO labeling. Patients on JATENZO should have their blood pressure monitored.

Among the 569 patients who received JATENZO in all Phase 2 and 3 trials combined, the following adverse reactions were reported in >2% of patients: polycythemia, diarrhea, dyspepsia, eructation (i.e., burping), peripheral edema, nausea, increased hematocrit, headache, prostatomegaly (i.e., enlarged prostate), and hypertension.

MedicalResearch.com: How doesJATENZO differ from other treatments for testosterone deficiency?

Response: The launch of JATENZO is an important step forward in testosterone replacement therapy. The only other oral testosterone replacement therapy product ever approved by the FDA is methyltestosterone (an alkylated androgen) that has been associated with serious liver toxicity and is rarely, if ever, used today. Because JATENZO is formulated as a lipophilic prodrug, it bypasses the first-pass hepatic metabolism. No liver toxicity-related events were observed in clinical studies of JATENZO including in patients who took JATENZO at higher doses than recommended in current product labeling for two (2) years.

We believe JATENZO addresses a long-standing need for a safe and effective oral testosterone replacement product that meets current day FDA safety and efficacy standards. JATENZO enters a market where the vast majority of hypogonadal men are treated with injectable or topical testosterone products. JATENZO avoids administration challenges seen with these non-oral treatments it presents no injection site pain, no transfer risk, no mess, no skin irritation and no surgical procedure. Therefore, we believe a significant number of hypogonadal men will prefer JATENZO as an alternative to other forms of testosterone therapy.

MedicalResearch.com: How are men tested to determine ifJATENZO therapy is appropriate for them?

Response: According to the American Urological Association and Endocrine Society clinical guidelines, diagnosis of hypogonadism is determined by both the identification of symptoms and/or signs consistent with hypogonadism and blood test measurement of low morning total serum testosterone concentration (defined as <300 ng/dL, on two separate days). Healthcare providers should assess each patient individually for the appropriateness of JATENZO to treat their clinical hypogonadism.

MedicalResearch.com: What else should readers take away from your report?

Response: Clinical hypogonadism can be more complex than most people realize and left untreated, can have a profound negative impact for the individual. Men with the symptoms of hypogonadism have a real medical need that deserves appropriate diagnosis and treatment.

Any disclosures?

Pleaseclick herefor full Prescribing Information, including BOXED WARNING on increases in blood pressure.

Citation:

CLARUS THERAPEUTICS ANNOUNCES COMMERCIAL LAUNCH AND AVAILABILITY OF JATENZO (TESTOSTERONE UNDECANOATE) CAPSULES, CIII FOR THE TREATMENT OF HYPOGONADISM

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Feb 19, 2020 @ 12:05 pm

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