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Bianca Andreescu has suffered more injury frustration after being forced to withdraw from the Dubai Duty Free Tennis Championships.

The US Open champion has barely been seen since her win at Flushing Meadows in September, and her knee complaint kept her out of the Australian Open as well.

The signs had looked positive earlier this month when she was named in Canadas Fed Cup squad, even though she never actually got involved in singles action.

However, it appears there has been another set-back, forcing her to remain on the sidelines.

Im very sad to announce that I wont be able to compete in the Dubai Duty Free Tennis Championships next week, Andreescu said.

Im not at 100 per cent yet and following my team and doctors recommendation, I dont want to take any risk to re-injure my knee.

Each day I get closer to being back to the court competing but Dubai is just too soon. I hope I can come and play in Dubai next year.

World number one Ashleigh Barty has also withdrawn from the event with a foot injury.

The line-up remains strong, though, with SImona Halep, Karolina Pliskova, Elina Svitolina, and Sofia Kenin all involved.

Related Articles

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Bianca Andreescu suffers further fitness setback as knee injury forces her out of Dubai Duty Free - Tennishead

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CHICAGO Losing weight remains a top goal for half of American adults, according to The NPD Group.

Around 25% of consumers will follow a specific diet plan in 2020, the market research company said, up from approximately 20% in 2016. Top diet plans include the low-carb, high-fat ketogenic or keto diet, and intermittent fasting, an eating pattern that cycles between periods of eating and periods of fasting. Around 5% of consumers follow the keto diet while 4% follow intermittent fasting.

Instead of adhering to a formalized diet or nutrition plan, 16% of consumers said they follow their own diet, which may include a range of personalized dieting patterns. Among the most common are eating more healthful foods and beverages and limiting the amount of food eaten, NPDs Health Aspirations and Behavioral Tracker Service found. The remaining percentages of consumers who follow a diet plan to lose weight are fragmented across a variety of other diet programs.

From the standpoint of food manufacturers and food service operators, dieting and trying to lose weight are big consumer behaviors, said Darren Seifer, food and beverage industry analyst at NPD. The opportunity is to help consumers follow through on their goals by positioning products and menu items to a specific diet, like keto-friendly, or innovate on new products that deliver on what consumers are looking for in terms of dieting or losing weight.

Not all consumers seeking healthier options are trying to lose weight, though. NPD also found that close to a quarter of U.S. adults reported being on a nutritional plan with the goal of promoting long-term health, but not necessarily weight loss.

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Half of U.S. adults want to lose weight in 2020 - Food Business News

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Eat healthier, lose weight, drink less alcohol, quit smoking these are some of the most common health-related new year resolutions. However, while its easy to resolve to make positive lifestyle changes on Jan. 1, challenges and barriers to success can emerge in the following weeks and months.

Dr. Marc Feldman, assistant professor of family and community medicine at Baylor College of Medicine, says only 46% of Americans who have made these and other resolutions have stuck to them after six months. Heres why:

Want to make your goals stick? Heres how:

If your resolution is to lose 60 pounds by spring break, thats likely not realistic. Instead, set a goal of bringing your lunch instead of eating out or taking a walk during your lunch break.

These goals help promote behaviors that will lead to long-term weight loss, said Emily Monfiletto, a senior registered dietitian at Baylor.

Build momentum toward your long-term goal. For example, if your resolution is to start exercising, take the first step by building no-cost, achievable activities into your daily routine, like going on short walks, taking the stairs instead of the elevator, or doing calf lifts while brushing your teeth. Then, you can tackle a gym membership or running a 5k.

SMART goals are Specific, Measurable, Achievable, Relevant and Time based. When goals are too generic, its hard to even get started, Monfiletto said.

Turn the goal of eating healthier into a SMART goal by tracking food and exercise through an app or journal, developing a plan of action after reviewing data, and making a back-up plan for days that more hectic.

Roadblocks are going to arise, Monfiletto said, but they shouldnt derail your resolution. One way to reduce them is to plan for busy days, week or months, and prepare for changes in routine.

Dont focus on the slip when it does happen; rather, focus on how you are going to get back on track. Also make sure to celebrate success, even if it seems small.

A support network is key to success, says Dr. Lizabeth Riley, an assistant professor of family and community medicine at Baylor. This can come in the form of a social network of friends, attending group exercise classes at a local gym, and even through online- and app-based fitness trackers.

Were in an electronic age, and so many things at our fingertips can be valuable resources, she said. Make use of apps like My Fitness Pal and Lose It. Many of them even have chat and networking functions so you can connect with others.

Dr. Marc Feldman, Dr. Lizabeth Riley and Emily Monfiletto are with Baylor Medicine. Learn more about healthcare services at Baylor.

Have resolutions? Heres how to keep them

Focus your resolution on lifestyle improvement, not outcomes

-By Dana Benson

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It's not too late to get started on resolutions - Baylor College of Medicine News

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Conceived by a self-proclaimed fasting coach with no apparent credentials in either the fields of nutrition or zoology, the Snake Diet appears to be nothing more than a contrived version of intermittent fasting.

Intermittent fasting, or extending the period of time between your last bite and your first bite (often from between 16 to 20 hours) is a potentially effective weight loss tool for those who can tolerate it. But the snake diet takes it to a whole other level hence the extreme weight loss results you might see online.

Robinsons protocol is based similarly on the One Meal A Day (OMAD) strategy. OMAD generally entails a daily fasting period of 22 to 23 hours with the remaining hour allotted to eating what would presumably be a large meal, whereas the snake diet regimen follows a multi-phase regimen that includes fasts of various lengths, between 24 to 96 hours, which are to be broken up by single large meals.

The diet also recommends drinking snake juice throughout the fasting period. The juice sold on Robinsons website is an electrolyte-enhanced beverage, which is essentially the equivalent of a sugar-free version of sports drinks like Gatorade, which contain sodium and potassium to make up for losses from sweat during activity. The purpose of this is likely to keep up electrolytes which tend to flag during fasts of this length. Sodium and potassium levels also could drop to dangerously low levels.

Is this a diet protocol worth trying? Unfortunately, many of the studies looking at fasts of this extreme length have been done in snakes hence the name rather than humans, so not all that much is known about the long-term safety, sustainability, or efficacy.

That said, while its not at all that absurd for an otherwise healthy individual who felt so inclined to do so to actually enjoy this style of fasting, it would take a lot of diligence and oversight to ensure a diet that was nutritionally adequate over the long-term. And lets not forget that because of the caloric restriction that tends to follow eating far less frequently, weight loss is not surprising.

But as a dietitian who has written about and reviewed the evidence on intermittent fasting, as well as practiced it personally, I can attest there are a number of metabolic benefits. However, the line between fasting and self-starvation becomes blurred when you start going multiple days in a row without food.

My advice to otherwise healthy people who feel compelled to try intermittent fasting is to steer clear of gimmicky approaches that give fasting a bad name. Ask yourself how long you can go from your last bite one day to your first bite the next and start by trying to go a bit longer. You may find that you enjoy it, or you may not. But if you find that intermittent fasting fits well with your lifestyle and supports you eating a high quality nutrient dense diet, then perhaps its worth taking a closer look at.

And with that, I slither off into the sunset.

Andy is a registered dietitian and multi-book author who has operated a private practice in Toronto since 2015.He spends his free time eating, writing and talking about kale @AndyTheRD. He can be reached at AndyTheRD.com

Original post:
Andy De Santis, RD: Is the 'Snake Diet' worth it? - The London Free Press

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Pharmacists can play an integral role in managing patients with inflammatory bowel disease (IBD) through medication management.

IBD includes the 2 conditions, Crohn disease and ulcerative colitis (UC), which involve chronic inflammation of the gastrointestinal (GI) tract. Crohn disease is characterized by inflammation that can affect any part of the GI tract.1 Inflammation occurs in the large intestine (colon) and rectum for UC.2 Symptoms of IBD include diarrhea, fever, abdominal pain, bloody stool, reduced appetite, and weight loss.2

Treatments and Counseling Points

Treatment for IBD generally involves either pharmacotherapy or surgery. An important counseling point is to avoid nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen, as these medications can exacerbate IBD symptoms and increase the risk of bleeding.3,4 Pharmacists can recommend acetaminophen for patients with IBD needing pain relief. The American College of Gastroenterology (ACG) clinical guidelines recommend management based upon disease extent, severity, and prognosis.3,4

Many of the same medications can be used to treat both UC and Crohndisease. Patients with mild UC can be treated with anti-inflammatory medications such as aminosalicylate therapies (5-ASA) as a first step in the treatment process.3 The 5-ASA medications (eg sulfasalazine, mesalamine, olsalazine) are generally well tolerated, and adverse effects may include headache, nausea, abdominal pain, vomiting, rash, and fever. Sulfasalazine has shown to be effective for treating mild-to-moderate symptoms of colonic Crohn disease.4

Corticosteroids (eg prednisone, budesonide) are generally reserved for patients with moderate-to-severe UC or Crohn disease.3,4 However, long-term use is not recommended due to the high risk of adverse effects including hypertension, increased blood glucose, cataracts, weight gain, osteoporosis, and psychiatric symptoms. One study showed that there was excessive steroid use in approximately 15% of patients with IBD.5

Anti-tumor necrosis factor (anti-TNF) medications such as adalimumab (Humira), golimumab (Simponi), or infliximab (Remicade) are biologics that can reduce symptoms and heal the intestine in patients with UC.5 Adalimumab, certolizumab pegol (Cimzia), and infliximab are the most effective anti-TNF therapies to treat moderate-to-severe Crohn disease.6 These medications may cause injection sitereactions, increase the risk of developing infections, and may cause changes in liver function so patients should beclosely monitored.

Biosimilar products are available for many of the anti-TNF drugs, which could make these medications more affordable for patients. Vedolizumab (Entyvio) is a biologic that is another option for UC and Crohn disease in patients who have failed other medications.3,4 Tofacitinib (Xeljanz), an immunomodulatory drug that decreases inflammation, is another option for UC.3 The FDA added a Boxed Warning regarding an increased risk of blood clots in patients taking tofacitinib 10 mg twice daily dose and discussed that this medication should be reserved as second-line therapy for individuals who failed or cannot tolerate anti-TNF drugs.6 Natalizumab (Tysabri) is effective for Crohn disease in patients who do not respond to conventional therapies, but it is associated with a rare brain disease known as multifocal leukoencephalopathy.4 Individuals must be enrolled in a special program to use the medication. Ustekinumab (Stelara) is used for moderate-to-severe Crohn disease that has failed other therapies and just received FDA approval on October 21, 2019 for UC.7

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What Pharmacists Should Know About Trends in IBD Treatment - Drug Topics

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Agile Therapeutics is a US biotech company based in Princeton, New Jersey. It currently has one leading candidate, Twirla, which is a weekly, lower dose estrogen contraception patch for women to avoid unwanted pregnancies. Currently it is waiting for FDAs final decision with a PDUFA date of Feb.16th, 2020.

Twirla has experienced an unusually rough path for the past 8 years (Fig. 1). Its original NDA submission can be dated back to 2012. Since then it has received FDAs complete response letter ("CRL") twice, indicating a difficult and unpleasant journey. We would assume readers are familiar with its history so we are not going to introduce the details. However, We are going to state several reasons why we think Twirla will very likely get final approval this time.

Figure 1. Agile patchs regulatory history. (Source: Internet)

Reason I: Efficacy

The biggest criticism of Twirlas efficacy comes from the fact that in its large-scale trial called Study 23, the overall Pearl Index, which is the pregnancy count per 100 women in one year of exposure, stayed around 5.8. This is well above the pearl indexes derived from previous contraception combined hormonal contraception ("CHC") trials (Fig. 2).

Figure 2. European and US Pearl Indices in Contraceptive Clinical Trials. (Source: Internet)

In fact, in Agiles Adcom briefing materials, this was explained in-depth. Historically, contraceptive clinical trials enrolled highly selective populations, like women with lower BMIs who responded to CHCs much better than women with obesity. Further, the current percentage of women population with obesity is much higher than that twenty years ago. In addition, those trials did not exclude individuals with inactive sexual activities. As a result, the exceptionally low Pearl Index did not transfer to real world efficacy, as the pregnancy rates post-marketing were many times higher than those observed in the clinical trials (Fig. 3).

Figure 3. The changing Pearl Index of approved combined hormonal contraception (NYSE:CHC) over time. (Source: Internet)

FDA was fully aware of this wide gap between clinical trials and real world efficacy. Multiple changes had been made in the regulatory guidance. In 2007, it removes the hard requirement on Pearl Index 95%CI upper bound and further adjust its guidance including:

1, Modifying trial designs to provide results that reflect effectiveness in the real world;

2, Changing entry criteria to reflect real-world prescribing; and

3, Ensuring that all relevant information be provided to the prescriber, including data on subgroups.

As a result, the Pearl Indices derived from contraception trials in the past two decades kept rising steadily, and it is of no surprise that Study 23 resulted in a larger overall Pearl Index of 5.83. The question is, how large is too large?

Lets first take a look at the sub-group of BMI < 30 (Fig. 4). The Pearl Index is 4.34 with a 95%CI upper bound of 5.82. A sample study estimate that at least 14% of adult women abstain from intercourse for the past 6 month. For simplicity, we will just use this 14% as the percentage of total cycles that no sexual activity occurs. If we add this number back to the denominator, we get an adjusted Pearl Index of 3.7 and a 95%CI upper bound of 5. We think these are very reasonable numbers, in-line with recent Pearl Index from commercialized oral CHC products (Fig. 3).

Figure 4. Pearl Index of Twirla patch by BMI category. (Source: Internet)

For women with obesity (BMI>30), the efficacy is suboptimal. But it is a well-known phenomenon. Larger body weight may contribute to lower estrogen serum concentration. Subcutaneous fat may also lead to poor skin absorption. keep in mind that even the existing patch Xulane has a label stating Xulane may not be as effective in women weighing more than 198 lbs. (90 kg). So it will not be surprised that Twirla may have a similar label.

In previous communication with FDA, Agile did get a note that FDA had never approved a CHC with upper 95%CI passing 5. However, during Oct. 2019s Adcom meeting, the committee suggested that, a slight increase in Pearl Index is expected under new trial designs. Further, comparing to 85% pregnancy rate without contraception methods, Twirla is well within the range of effectiveness. These comments from field experts conclude that Twirla is an effective contraception patch.

Lastly, inside FDAs 2017 CRL, the regulator raised questions about Twirlas adhesion property. In response to FDAs questions, Agile conducted Study 25, a comparative wear study comparing the adhesion of Twirla to Xulane. The result is crystal clear: the Agile Patch has directly demonstrated non-inferiority to Xulane (Fig. 5).

Figure 5. Primary adhesion endpoint of Study 25. (Source: Internet)

From all above evidence, we think there is little reason that FDA would raise more questions on Twirlas efficacy.

Reason II: Safety

The safety profiles for Twirlas two APIs, ethinyl estradiol and levonorgestrel were well studied. In the pooled analysis, Twirla showed a better safety profile over other CHC oral therapies, in respect to hormone-related AEs (Fig. 6). The possible reason could be that Twirla does deliver a much lower dose of estrogen, as the company stated. For non-hormone related AEs, the most common ones are application site disorders (5.7%) including irritation, pruritus and rash.

Figure 6. The hormone related AEs in pooled data. (Source: Internet)

For SAEs, because CHCs were known to increase the risk of thromboembolic event by approximately 2 to 4 fold, special attention was given to patients who experienced deep vein thrombosis (DVT) and pulmonary embolism ("PE"). It was noted that both DVT and PE had an occurrence rate of around 0.1% among Twirla users, and women with higher BMIs are more prone to have thromboembolic events. These results are all inline with approved CHCs products.

The discontinuation rate for Study 23 is slightly higher than other CHCs (Fig. 7). However, a close examination revealed that a 26.6% people who discontinued the trial were due to either loss of follow up or subject decision. And the discontinuation rate due to AEs are around 10%, also inline with other CHCs.

Figure 7. Comparison of study discontinuation rate with other approved CHCs. (Source: Internet)

In conclusion, Twirlas overall safety profile is acceptable and consistent with approved low-dose CHCs. The most common AEs and SAEs were expected, occurring at low rates, and led to discontinuation at rates similar to approved products. There were no further risk-related concerns specified by FDA. We dont expect FDA would reject Agiles NDA due to safety reasons.

Reason III: Market demand on more contraception options

One of the biggest values Twirla brings to the market is the additional option that women can choose when considering different contraception methods. One need to choose the right option based on invasiveness, routines and efficacies. Assume readers are familiar with pros and cons of different contraceptive methods, we are not going to compare them here. However, one could argue that, Twirla does not provide enough differentiation towards Xulane, since both of them are patches delivering similar types of hormones and Twirla has yet to prove that its lower dose estrogen (Fig. 8) could actually lead to statistically significant safety profile. Although this is a fair argument, we dont think it will happen this time: FDA could simply bring this issue up back in 2017 but it didn't.

Figure 8. Mean serum concentration-time profile of ethinyl estradiol across various contraceptive methods. (Source: Internet)

Further, Agile proposed to conduct post-marketing studies to show the clinical benefit and risk profile. If the reduced thromboembolic risk could be verified, it could potentially be a great market driver, as history has demonstrated womens strong preference to conveniently used, weekly, non-invasive contraceptive patches. Ortho Evra patch once reached a stunning 10% of the entire contraceptive market, with close to 1M annual prescribers. Now, because of its risks in thromboembolic events ("TE"), its generic version, Xulane only has about 100K prescribers. If, lets say if Twirla gets very lucky and could show its preferred safety on TE in post-marketing studies, it could regain the market share that Ortho Evra patch lost in the past.

Reason IV: Trial design up-to-updated standard and a comprehensive NDA package

Lastly, considering Agiles entire NDA package, we think it is comprehensive, already addressing all FDAs concerns (Fig. 9). Further, comparing to previous contraceptive trials, we think Twirla trials design reflect the up-to-date, real world scenario about potential users demographics and associated risks.

Figure 9. Checklist for issues raised by FDA. Note the last two items have been checked as well. (Source: Internet)

Given all above evidence, we think Twirla has a 95% chance of approval. The market however, thinks the chance is around 70%. This 70% number can be derived from the option market, where a 250% implied volatility over 5 days indicated an average move to be around 35.4% (calculated by 250% * sqrt(5/250)). If we assume a zero stock value for no approval, we get the market implied probability of approval to be 1/1.354 = 73.8%.

Valuation

Agiles stock has almost doubled since Oct.2017 Adcom meeting and resulted in a current market cap of $220M. We think the valuation is very rich now. If Twirlas price is set at $50 per patch, resulting a $1800 annual subscription price, we think the maximum possible peak revenue it can generate is $200M, assuming it completely occupied Xulanes current market share. More realistically, we think it probably will grab about 50%~60% of the Xulanes current market share, giving the fact that Xulane costs about $38 per patch, slightly cheaper than Twirla. This implies Twirlas peak sale of $120M, resulting a roughly $300M valuation using discount cashflow method. This indicates a 40% upside to the current stock price, if getting approved. In addition, given the fact that Agile only has about $10M cash in hand and currently burns $5M plus per quarter, it definitely needs to raise additional capital, likely around $45M. The combined effective upside potential is merely 25%. The call options associated with the stock currently trade at 280% IV, we think this volatility over-estimate the upside moves.

Management

When we examine the qualification of Agiles executive team, we are actually impressed by their M&A capabilities.

Agiles current CEO, Alfred Altomari, was once the CEO of Barrier Therapeutics. In 2008, in his role as CEO and as a member of Barrier's board of directors, Mr. Altomari completed the successful sale of Barrier to Stiefel Laboratories, which was subsequently acquired by GlaxoSmithKline plc.

The newly joined CFO, Dennis P. Reilly (joined in Aug, 2019) has proven to be an even better M&A expert. Dennis and Alfred were colleagues in Barrier Therapeutics back from 2005 to 2008, where Dennis served as the CFO and carried forward the Barriers acquisition. From 2009 to 2017, he served as CFO of NeoStrata Company, Inc., a privately held global leader in dermocosmetics, which was sold to Johnson & Johnson. In 2017, he served as CFO and COO of Invisible Sentinel, Inc a private company, which BioMerieux acquired in February 2019. Time and time again Dennis has demonstrate to the public how capable he is to successfully sell his companies and maximizing shareholders return.

These are very strong indicators pointing to the fact that the executive team of Agile may consider selling out the company in the near future. For the past years, we knew Mylan Pharmaceutics successfully defended its Xulanes market share and won the competition over Agile. However, if we put grudge aside, Mylan is actually a perfect buyer for the company. Mylan is currently the only contraceptive patch player in the market which means it does not need to hire additional sales force. They have enough resource to do a post-marketing trials to demonstrate Twirlas safety advantage over Xulane. If they can demonstrate that Twirlas safety is inline with other low-dose oral CHCs, they may be able to greatly expand contraceptive patchs market share by several folds, reaching over $2B in peak sale. Other companies, such Johnson and Johnson, could also be potential buyers as well. In conclusion, Agiles executive team leaves investors with imaginations of a potential sale in the near future.

We are currently invested in the stock, and we plan to exit the position right after FDAs decision. We are most confident about Twirlas FDA approval decision and we do not want to gain exposure to future uncertainties.

Author: Weiwei Wang

Disclosure: I am/we are long AGRX. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Additional disclosure: Investors are always reminded that before making any investment, you should do your own proper due diligence on any name directly or indirectly mentioned in this article. Investors should also consider seeking advice from a broker or financial adviser before making any investment decisions. Any information mentioned in this article was not verified, and should not be relied on as a formal investment justification. All recommendations and other statements, unless specified, are based on the author's personal understanding/judgement and may subject to future changes.

Read the rest here:
Short-Term Catalyst And Long-Term M&A Potential Make Agile Therapeutics An Attractive Potential Takeover Target - Seeking Alpha

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History will not repeat itself this year for the Cornell wrestling squad the Reds 92 straight streak of Ivy League dual victories came to an abrupt and devastating halt this weekend against the Princeton Tigers.

For the first time in 17 years, Cornell wrestling will not take home the Ivy League championship trophy.

Its a disappointment, not a tragedy, said head coach Rob Koll. We always expect to win the championship its been 17 years since we havent.

But you have to be realistic, Koll continued. This is not the same team that we have had for the past 17 years. We had the ability to win that match with the team we have in place, and we let it slip through our fingers.

The historic loss came on the back of a victory against Ivy League foe University of Pennsylvania the day before. With a final score of 30-6, the team had moved one step closer to another Ivy League title.

The Red (9-6, 4-1) opened the duel on Feb. 8 against the Quakers (5-6, 4-3 Ivy League) with a close loss at 141 lbs. However, the team quickly recovered clinching seven consecutive individual victories to amass a 27-3 lead.

Junior Hunter Richard, who recently earned the No. 25 rank in the 149 bout, put the Red on the board. Junior Adam Santoro and sophomore Jake Brindley followed suit with 7-1 and 5-1 wins, respectively. Sophomore Andrew Berryesa also bested his Quaker opponent with a 7-6 win.

Channeling the momentum of the match, freshman Jonathan Loew used a takedown to stick his opponent 5:47 into the dual. Sophomore Ben Darmstadt returned to the mat after a Jan. 11 injury against Columbia put a short damper on his season. But, it was as if he had never left the arena, pinning his opponent in a mere 24 seconds.

Sophomore Brendan Furman was the victor of the heavyweight bout, and senior Chas Tucker sealed the results of the dual with his 10-3 triumph, which consisted of five takedowns.

After vanquishing the Quakers, the Red headed to Princeton, N.J., gunning for the Ivy League championship title. However, the Tigers humbled the Red and slashed its 17 year winning streak.

We got out there and wrestled our hardest, pushed as hard as we could, said senior Chas Tucker. The outcome was not what we wanted, but we did the best we could.

The dual commenced in favor of the Red with a 9-0 major decision in the heavyweight bout. The Tigers tied up the score with a major decision of its own in the 125 weight class. With wins from Tucker and senior Noah Baughman, the Red took back the lead from Princeton. Tucker kept his flawless individual record in tac improving to 15-0 in dual competition.

For this highly-anticipated match, the Tigers commissioned its three-time All-American Olympic redshirt Matt Kolodzik to wrestle in the collegiate match. Richard met Kolodzik with a valiant effort, but it was not enough to conquer his stand-out opponent.

Although Cornell did not lose the lead at that point, it was slowly slipping away. The Tigers picked up and sustained its winning momentum, while the Red dropped four consecutive bouts at 157, 165, 174 and 184 lbs.

They did a really good job getting those toss-up matches, and then overturning some of the matches that were maybe initially tipped in our favor, Tucker said. They capitalized where we could have, and they pulled out those close matches. That made the difference for the whole dual and what ultimately won them the dual.

Heading into the last match of the day, the duals decision was practically sealed in the Tigers favor.

Despite the bleak score, the Red refused to give up, with Darmstadt closing out the day with an exceptional win against No.3 Pat Brucki, almost clinching the major victory. Unfortunately, the 11-4 win in the final round proved insufficient to recapture the lost Ivy League title.

Hats off to them they were able to take this one, Koll said. They arent going to be able to get used to it, though, because we will be back next year, and we will get that trophy back where it belongs. The trophy is coming back to Ithaca next year.

The Red will face Binghamton on Saturday at 1 p.m. and North Carolina on Sunday at 1 p.m.

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Men's Wrestling Loses the Ivy Championship Title - Cornell University The Cornell Daily Sun

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Virus are all the time mutating. The reason mutations are a problem with virus is because (A) there are so many and (B) they reproduce so quickly.

It's estimated that there are 10 to the 31 virus in the world. That's:

10,000,000,000,000,000,000,000,000,000,000 or

10 million trillion trillion

This is far more than all the stars in the universe.

Even though the chance of a mutation in any particular reproduction is very, very small, because of the enormous number of virus and their very short reproductive cycle, mutations regularly happen.

Virus are microscopic. But, because there are so many, if they were laid end to end, they would stretch 100 million light years. In one gram of dental plaque, there are more virus than all humans who ever lived. In your gut, there's a pound of virus. Over the course of a year, you evacuate more than your body weight of virus.

Obviously, we are fighting virus all the time. Almost always we win. But, sometimes, we lose. Actually, since virus are parasites, they don't really want us to lose. They want us to get sick, but not die. But, sometimes things get out of control.

Good sanitation and habits of cleanliness are really important to keep things under control. Historically and still in many countries, poor sanitation is a contributor to viral and other contagious diseases, with consequences including listlessness and stunted physical and mental development.

When there were few of us, and we were dispersed over a wide area, sanitation and cleanliness wasn't so important. But, being increasingly an urban species, sanitation and cleanliness are, today, absolutely necessary.

As to whether virus are a form of life is controversial. They have genetic materials and reproduce, but only with the assistance of a host cell. Host cells range from bacteria to the cells of advanced plants and animals. The virus hack into the host cell, and cause the host cell to reproduce more virus of the same kind.

When the host cell is exhausted, a multitude of virus attacks other cells of the host life form, or migrate to other like life forms. The transmission from one to another life form can happen when coughing or with the aid, for example, of an insect.

Living as we do with virus within us and all around us, our bodies have both generic and specific defenses against virus. As we grow from infancy to adulthood, we usually develop more defenses. But, when young or debilitated by sickness or old age, our immune systems are weakened and we are vulnerable.

Vaccines, once developed, can be helpful; but, can be costly and may have side-effects. In any case, they won't be immediately available.

Historically, times of the introduction of new contagious disease combined with harsh winters, crop failures, and other conditions weakening an entire population, were times of devastation. During the Bubonic Plague or Black Death, perhaps half of the population of Europe succumbed to contagious disease.

Through the early years of the Republic, our cities suffered recurrent outbreaks of yellow fever. Cholera, always a problem, periodically rose to epidemic proportions. The Spanish Flu, following World War I, infected a quarter of the world's population, and claimed the lives of perhaps 4 percent.

A few years ago, it was ebola. Today, the coronavirus. Tomorrow, because of mutation, it will be something else.

Read more:
News - The Real Threat of Viruses - The Heartland Institute

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The most effective fat burning exercises consist of cardiovascular workouts as well as strength exercises that can help get your body in shape. To lose weight healthy you should choose a sport or physical activity that best suits your needs. That's why we present to you 12 physical activities for effective calorie burning. Dont forget that you are going to need adequate equipment that will maximize your potential and prevent/minimize injuries. You can alwayscheck it out hereto be sure you got the top-quality gear.

An easy, fun and inexpensive way to lose weight is to dance. You can do this physical activity at home, it is enough to play your favorite music and just dance for an hour. Find YouTube channels that can help you learn various dance moves. An hour of dancing burns from 600 to 800 calories.

Tennis is a fun sport that also helps with weight loss. It requires constant and fast movement, which is an ideal way to burn calories. It also gives you a great opportunity to socialize and try something new.

It doesnt matter if it is summer or winter, you can always go for a swim. An hour actively spent in the water shapes the whole body and burns 800 calories. If you go swimming with friends, you can also play numerous games in the water.

Another activity for eliminating stress from the body is kickboxing or just boxing, which is also an ideal way in your journey to weight loss. An hour of practicing the sport burns 600 calories. You can meet new people, find a sparring partner, and learn self-defense.

Sports such as football, basketball and handball require constant movement and running. This kind of cardiovascular activity helps burn fat quickly, and group sports are fun too.

Stretching and yoga, in addition to helping relieve stress, lower back pain and improve body flexibility, is also an effective way to lose weight. An hour of yoga burns 180 calories, and if you do more demanding exercises it will help you lose weight faster. YouTube is filled with channels that will teach you various types of yoga, and if you like to socialize you can always find a studio nearby.

An easy but very effective way to lose weight is to run or jog. Beginners are advised to combine slow and light jogging with short sprints and fast walking. Such interval training successfully burns calories. To make it more fun, choose your favorite music or find a friend that will join you.

Whether you use an indoor bike or ride it outdoors, cycling is a good way to burn calories, especially if you go for an uphill ride. An hour or so of cycling burns from 500 to 1,000 calories. Find a bike you like and explore the world around you. Discover a new park in your area, a coffee shop, and other interesting things.

Any type of exercise that involves jumping helps to burn calories, such as jumping rope or jumping on a trampoline. Training consisting of squats and jumping is also a great activity for burning fat and strengthening your muscles.

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Fun Activities that will Help You Lose Weight - State-Journal.com

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Free promotional e-book also offered, filled with meal plan tips and secrets to help enthusiasts get started on the road to a new healthy lifestyle.

LONGVIEW, Texas, Feb. 10, 2020 /PRNewswire/ -- Popular coaching personality Damen Griffith (https://damengfit.com/) recently announced the creation of his individualized, one-on-one online coaching support program, now available for a limited number of clients. Having gained fame and the trusted support of over 25,000 clients and fans throughout his career, Damen's upbeat, positive attitude and frequent successes have quickly propelled him into the fitness and life coaching spotlight. Damen created the new program to continue his commitment to offering his extensive coaching expertise for those who need it.

"Sure, we all want to look good," said Damen Griffith. "But at the end of the day, I care most about helping people. I know how difficult it is to reach those personal weight goals, those sculpting goals it's a long road with a lot of major bumps and hurdles. The wrong exercises, the wrong meals, the wrong attitude, and even the surprises that life can throw you: all of these can totally derail a fitness plan losing you countless hours of work, and draining away your confidence. That's why you absolutely need a good coach. Someone who's been through it; someone who can help you put together a personalized plan and stick with it. I'm a mentor who'll be there whenever you need me: with texts, calls, whatever it takes to keep you on track."

"Managing Your Foods for Your Goals" Free Guide

One of the pillars of any good exercise and body-sculpting regime is an excellent dieting and meal plan. As part of Damen's one-on-one teaching, a great deal of consideration will be given to the importance of foods and liquids that are consumed. Damen has already put together a solid primer to begin orienting new clients into the process of thinking about their eating habits. That guide is also available to those with a general interest in healthy living.

"Managing Your Foods for Your Goals" includes information on how to eat for:

While other detailed sections of the book focus on:

Everyone is welcome to sign up for a free copy of the guide HERE.

Multiple 5-Star Reviews

Client reviews for Damen's individualized coaching plans have always been overwhelmingly positive:

"The custom workout and meal plan he's made for me has yielded amazing results: I'm in the military, on a meal card, but he still managed to make a meal plan out of my food choices that worked perfectly for me. Always a text message away whenever I had questions, he regularly checked up on me and my progress and added different workouts and changes, depending on how my fitness goals were coming along." ajxm09

"Definitely worth it! Damen is super flexible and a great coach! Creates meal plans and workouts to your body, and how you want to grow! Stays in touch and checks up regularly. 10 outta 10 recommended!" noahaguillard1994

"The fact that Damen will work with anyone and everyone that is motivated to make a lifestyle change is amazing in itself. This is the first experience that I have had where the communication is so personal to my life, that even little changes when I cannot focus my full attention on the nutrition and workouts have still yielded results that I thought I'd never see." ryanjmiller421

Program Sign Up and Social Media

Because of Damen's limited time, and the nature of the individual attention required, the new program is offered to only a select few individuals, and will fill up quickly. Damen encourages those interested to go online immediately to find out more.

Follow Damen Griffith's personal goals and learn more about his programs on his extremely active social media accounts: Facebook, Instagram, YouTube, Twitter.

Subscription service for 7/month to receive custom daily coaching and training and tips tricks strategy recipes coupons exclusives etc.https://dailywithdamen.com/squeeze-page

Free Body Type Tool with Actionable Value Immediately.https://griffithshred.com/vsl-order-form

Digital Course: On-demand, One on one digital access DIY / DWY Fitness, Mindset, Nutrition, Lose fat build muscle, change your life course.https://builtbydamen.com/vsl-order-form

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Social Media Body-Sculpting Superstar Damen Griffith Announces Limited Spots Available for New One-on-One Online and Coaching Mentorship Program --...

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