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The market intelligence report on the Testosterone Replacement Therapy market forecasts its growth during the years 2019 to 2022. It examines the market size, share, demand, trends, gross revenue, total earnings and net value after a historical analysis of the data collected from the years 2019 to 2022 while taking 2018 as the base year. The study focuses on the driving factors, restrains and hurdles for the growth of the market. The researcher gives market insights relating to the upcoming areas in the business and the impact of technological innovations on the growth of the market.

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The size of the Testosterone Replacement Therapy market is viewed in terms of the Share of Market, Total Available Market as well as Served Available Market. Not only does the study present the combined revenue for a particular market but also the market size for a specific geographic region. Analysis of percentage or the size of the Total Available Market based on the type of product, technology, regional constraints and others form an important part of the Testosterone Replacement Therapy market report.

Scope of the Report:

This industry assessment for the forecast period, 2019 2022 incorporates projections pertaining to the investment feasibility, gross margin, profits, consumption volume, production capability and major market vendors. Likewise, statistics associated with the competitive landscape, shifting consumer behaviour and spending power is showcased and well-explained with the help of treasured resources such as charts, graphs and graphic images, which can be easily incorporated in the business or corporate presentations.

Segments covered in the report:

In market segmentation by manufacturers, the report covers the following companies

In market segmentation by geographical regions, the report has analysed the following regions

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In market segmentation by types of testosterone replacement therapies, the report covers

In market segmentation by applications of the testosterone replacement therapy, the report covers the following uses

Apart from this, the study assesses the weaknesses and strengths of the major market players operating across different regions. Analysis of prominent trends from past and future that is actively contributing to the growth of the Testosterone Replacement Therapy industry further plays an eminent role in helping business owners plan effective business strategies. Evaluation of various aspects such as import and export status, distribution channel, supply chain management, profit and gross margin is explained extensively in the report.

The research provides answers to the following key questions:

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Original post:
Testosterone Replacement Therapy Market CAGR Growth Expected to Be Linear Says AbbVie, Endo International, Eli lilly - Alpha News Report

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I see health-focused trends rising and gimmicks falling, Phillips says. This list is such an insight into what role fitness plays for society. It's not just about looking good, staying slim, getting fit and gaining muscle, as once pigeonholed, but now is viewed as a much broader approach to health.

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"This year's trends indicate that we are looking to fitness to support mental health, community, connection, disease prevention and innovation.

The rise of wellness coaching, for example, which uses behavioural science and positive psychology to support physical and mental health, suggests a growing interest in how our mind and body work together, Phillips says.

EIM (exercise is medicine) is climbing too, along with exercise for older adults. These trends all have a strong health focus which is really encouraging to see.

Libby Babet, the founder of BUF Girls and former trainer on the Biggest Loser, is equally enthusiastic.

Usually when I look at the top 20 I do a bit of an eye-roll at a few fads or quick-fix trends, but this year everything in the top 20 is things I feel get real results, she says.

We're all a bit more clued in on health and fitness these days, society as a whole is more informed and more curious about what works.

I think this is because we're all a bit more clued in on health and fitness these days, society as a whole is more informed and more curious about what works.

The continued trend of wearable tech (it has been number one since 2016) reflects its continued innovation.

Wearable tech is just getting better and better, isn't it? Most devices aren't just clocking your energy spent or distance covered anymore, they're monitoring your health and wellbeing and really getting to know you and how your body is adapting. They've become a real guide, says Babet, who favours the Apple Watch.

Founder of Flow Athletic, Ben Lucas says a trend towards active transport is also driving the popularity of wearables.

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People are doing more incidental exercise today (walking, cycling) and they like to have a benchmark to hit, Lucas says. Also the element of gamification (movement streaks, competing against friends) keeps consumers engaged.

Despite the technology trend, mobile exercise apps are on the decline. Lucas attributes this to the lack of accountability and impetus they provide to exercise.

It is so easy to register, download, sign up but it will just sit there on your phone if you dont open it and take the time to commit to the program, he says. [Its] the same reason that people have exercise equipment at home that goes unused, they are not missing a means to exercise, they are looking for motivation to get it done.

People still value the face-to-face connection gained through social fitness as well as the desire to exercise in a different location.

In that way I dont ever believe that group exercise and personal training will ever completely go out of fashion. Having the accountability to someone else and the inspiration from a group setting will help you commit and get results.

Phillips agrees that the social aspect is crucial for many people.

People still value the face-to-face connection gained through social fitness as well as the desire to exercise in a different location (be it outdoors or the gym), she says. I am a big believer in combining fitness with fun and friends, so to see group fitness still in the top three makes me smile. Jane Fonda was really onto something wasn't she!?

Sarah Berry is a lifestyle and health writer at The Sydney Morning Herald and The Age.

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The 'great joy' to be found in the 2020 fitness trends - The Age

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The Senior Program at the Greater Maple Valley Community Center, located at 22010 SE 248th St. in Maple Valley, invites all adults ages 50+ to come and see what we are all about! Call us at 425-432-1272 with any questions or visit our website http://www.maplevalleycc.org for more information and our monthly calendar.

We would like to offer our sincere thanks to Covington Place Sr. Apts. for their continued support of our programs.

Trips, Groups, Special Events

Payment for all trips is due at time of registration. Cancellations are refunded if seats can be filled; a $5 non-refundable service fee will be applied. Trip costs include all Community Center and travel expenses.

Friday, December 20 Holiday Lunch Celebrate the season with friends at our annual Holiday Lunch. On this day, Bingo will run from 10-11a.m., followed by a vocal performance by the Honor Choir at Lake Wilderness Elementary, and a very special visit from Santa (with photos)! Lunch will be served at noon. Cost for lunch is a $4 suggested donation for those age 60 and over, and a $7 fee for anyone 59 and under. Please sign up in advance for this event so we know how many to expect.

Wednesday, December 25 CLOSED Wednesday, January 1 CLOSED

Tuesday, January 7 Senior Trip: Reptile Zoo The Reptile Zoo in Monroe provides a unique opportunity to get up close and personal with exotic reptiles from across the globe: including turtles, alligators, lizards and many types of snakes. You dont want to miss the turtle with two heads, the albino alligator, and the worlds deadliest snake the black mamba. Be prepared to have fun and enjoy quality time with these magnificent creatures! We will leave GMVCC at 9:15, and will have lunch together at the Maltby Caf after visiting the museum. Cost is $18, plus $8.95 admission at the door. You will also need to bring money for your lunch.

Tuesday, January 21 Senior Trip: Seattle Antiques Market and Dukes Seattle Antiques Market is one of the largest collectibles and antiques dealers in Washington! This 6,000 sq. ft. store is filled with thousands of treasures from the past. Youll discover a wide selection of antique furniture for the home, nautical antiques, collectible vinyl, vintage typewriters, vintage cameras, mid-century modern home decor, antique office furniture, vintage toys, and much, much more! We will leave GMVCC at 9:30a.m., shop for a while, then head to Dukes Chowder House for lunch. Cost is $15, plus money for shopping and lunch.

Senior Fitness

Mon/Wed/Fri at 9:00a.m. Walking Group Meeting in the GMVCC lobby MWF at 9:00am, we walk on the Lake Wilderness Trail as a group, rain or shine. Everyone walks at his or her own pace; covering approx. 3 miles round trip. This is a drop-in activity; no need to call ahead. There is a $1 suggested donation to support on-going GMVCC Health and Wellness programs.

Mons and Weds., at 9:00a.m. Aging-Well Yoga Instructor will help you gently increase strength, flexibility, posture and balance. Everyone will be working at their own pace. 4-class punch card is $30; 8-class punch card is $50; 12-class punch card is $70; drop-in rate is $10. No reservations are necessary; pay in class. This class is held in The Den. Call us with any questions.

Mons., Weds. and Fris. at 10:30 Fall-Prevention Exercise The Fall StopMove Strong exercise program was designed specifically to improve balance and strength. It is a series of 3 different 12-minute sessions. This is free and no sign-up is necessary. Please note: no exercise on party days.

Socials and Games

Time and availability might vary because of holidays and parties. Suggested donation of $1 in the activity donation box.

Mons. Bingo at 11:00; Pinochle at 12:30; Ping Pong 12:30

Weds. (2nd & 4th Weds.) Quilting & Sewing at 10:45 in the Den; Bingo at 11:00, Pinochle at 12:30

Fris. Bingo at 11:00, Painting at 1:00, Ping Pong 12:30, Pinochle and Mah Jong at 12:30

Fris. at 1:00 Painting

Calling all painters (all mediums) to come in to use our main hall to paint, socialize, and share ideas. Tables and space to spread out is available, however, there are no easels for use, and no instruction given.

Lunch Menus

Lunch served each Mon., Wed., Fri. at 12:00. For those age 60+ there is a suggested donation of $4. For all others, there is a $7 fee.

All menus are subject to availability of food items. Milk, coffee, and tea are available for all lunches.

Wed., Dec 18: Beef Stroganoff, Normandy vegetables, oranges, milk, birthday cake

Fri., Dec 20: Baked Ham, scalloped potatoes, green beans, bread pudding, warm pears, milk

Mon., Dec 23: Minestrone Soup, garden salad, bread stick, apple crisp, milk

Wed., Dec 25: CLOSED

Fri., Dec 27: Chicken Pot Pie, broccoli salad, peaches, roll, milk

Health and Wellness

Routine Pedicure/Footcare Karens Foot Care is offered to seniors on the 2nd & 4th Friday of each month and the 4th Thurs. Cost is $32. Please call GMVCC to make an appointment as this popular service fills quickly.

Blood Pressure Checks are offered on the 1st and 3rd Fridays between 10:30 and 11:00. This service depends on availability of MV Firefighters.

Services

Community Center Shuttle Need a ride in? Our shuttle runs M/W/F between 9 a.m. and 3 p.m. and provides rides to GMVCC for programs and lunch. Shuttle rides are $1 each way within our transportation boundaries. Call 425-432-1272 for availability at least 24 hours in advance. $20 bus passes (good for 20 rides) are available.

Volunteer Transportation Need a ride to a medical appointment? Call Janet at 425-432-1272 at least one week in advance to arrange a free volunteer-provided ride. This Volunteer Program is now in great need of drivers. If you think you would like to help seniors get to medical appointments, please call the above number to become a volunteer.

Meals on Wheels (by application only). Applications must be obtained from and submitted to Sound Generations (call 206-448-5767 or mealsonwheels@soundgenerations.org and http://www.soundgenerations.org). A new, expanded menu is now available.

Free Pet Food In partnership with the Seattle Humane Society, the Greater Maple Valley Community Center offers free pet food for qualifying low-income seniors.

Medical Lending Closet Free walking aids & bathroom equipment are available from our lending closet free of charge(call for current items). We also welcome donations of these items!

Cell Phone Drop Off Drop off your old cell phones here to be distributed to US military as well as people in general disaster areas. This is part of the Phones for Soldiers Program. More information can be found at: http://www.cellphonesforsoldiers.com

Eye Glass Drop Off Drop off old prescription glasses here for the Lions Club to refurbish and redistribute to those who need them.

Computer Assistance Volunteer Curtis Patterson specializes in working with senior citizens and provides free, caring, patient, one-on-one computer assistance including repairs, upgrades, diagnostics, tutoring, virus/spyware cleaning, and more. PC and Android are his specialty, but Curtis is willing attempt to help with Apple products as well. Call us at 425-432-1272 to arrange and appointment. Age requirement is 50+.

Read the rest here:
Maple Valley Senior News Updated 12-17-19 - Voice of the Valley

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Here in the valley of the sun, many people are already retired. But what do you explain to someone who is not sure whether or not they are ready to retire? Of course, one of the most important factors is of the financial nature. Questions begin to arise. Will you receive a pension? If so, will it include a COLA (cost of living adjustment)? How much will your social security be? Income becomes very important when a person is ready to retire.

Inflation is the silent eater of a persons money as time goes by. Even at 3-4%, if your income remains stable, inflation will slowly erode your purchasing power. As you know, prices on most goods and services go up, not down. So, remember to know in advance what your approximate income will be before you actually retire from your job.

If you were able to save money, either through work sponsored programs such as a 401k or thrift savings plans, or individually through IRAs or Roth IRAs, you are ahead of the pack. Saving money and having it grow through solid investments and having time for it to grow is very important. So, make sure that while you may be eying retirement in a few years, saving your hard earned money is very important.

We work hard all of our adult lives to save money and try to live a comfortable lifestyle and, consequently, accumulation of money is important, but when you retire, distribution becomes more important. Having money that will provide current income and not running out of it becomes more vital. One big fear of people who retire is outliving their money.

Another important factor when deciding when too retire is debt. If you have a mortgage or outstanding loans, will they be paid off before you retire? Having large amounts of debt can really cripple someone mentally. Many divorces are directly related to debt and money issues.

So, now you have a comfortable number and are ready to officially call it quits. The next major question is, what are you going to do? Here is where it is very important to have a plan. Through my thirty years in the financial field, I have seen people who cant wait to retire and have wonderful plans to travel and do interesting things. I have also seen the other side, where people are forced into retirement due to health reasons or various other issues. Being able to retire on your terms is certainly, without question, the best. Planning is crucial to having and enjoying a successful retirement.

As we age, it is important to interact with younger people to some degree. This may consist of being involved with the grandchildren or friends. Planning is really as simple as answering the questions, What kind of life do you want to live? Where do you want to live? What is it you always wanted to do, but never had the time? Remember: retirement is supposed to be our golden years. This is the time for you to go or do anything your heart desires.

All of this may sound wonderful, except one thing: health. The old saying, If you have your health, you have everything, is so true as we age. Begin, if you have not already, starting an exercise program of some kind. It may be as simple as just taking a long walk every morning. The key is to be consistent. Taking care of yourself and your money are just a couple of important parts of any successful retirement.

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Money Matters: Many Factors in Deciding to Retire - Apache Junction News

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For information, visit dovertownlibrary.org, or call 508-785-8113.

The Dover Town Library, 56 Dedham St., is open Mondays, Tuesdays and Wednesdays from 10 a.m.-8 p.m.; Thursdays and Fridays from 10 a.m.-6 p.m.; Saturdays from 10 a.m.-4 p.m.; and closed on Sundays. For information, visit http://www.dovertownlibrary.org, or call 508-785-8113.

Find us on Facebook and Twitter.

Holiday closings: The library will close at 1 p.m. on Dec. 24, and remain closed on Dec. 25 for the Christmas holiday. The library will close at 3 p.m. on Dec. 31, and remain closed on Jan. 1, for the New Years holiday.

Adult & Family Programs

Qigong

Every Monday from 5:30-6:30 p.m.

Qigong is a practice of aligning breath, movement, and awareness for exercise, healing, and meditation. This program is sponsored by the Dover Council of Aging.

Oodles of Doodles

Every second and fourth Tuesday of the month from 1:30-3 p.m.

Join us for some art therapy at this adult coloring session. Supplies and space provided.

Virtual Reality Freeplay

Every Thursday from 3-5 p.m.

Every Saturday from 1:30-2:30 p.m.

Come to the library to try out the HTC Vive virtual reality headset. Test out a variety of games and simulations such as The Blu, Space Pirate Trainer, Job Simulator, and The Lab. Due to popular demand, we are now offering Virtual Reality on Saturdays, too! Open to ages 10 and up.

Caregivers Support Meeting

Every Tuesday from 11 a.m.-noon

Every Friday from 1-2 p.m.

Caregiving is a tough job. The journey often feels overwhelming and lonely. If you are a wife, husband, parent, or a friend who offers care to an Alzheimers patient or a patient with a long-term health challenge/trauma, Dover Town Library would like to offer you a safe space to refresh, have coffee, chat, and meet with friends.

3D Printing Workshop

Tuesday, Jan. 7, 6-7 p.m., Community Room

Learn the basics of Computer Aided Design using tinkerCAD.com. This hands-on class will go over the basics of creating 3D models that can be turned into real objects with a 3D printer. A basic understanding of computers is necessary.

Childrens Programs

Super Awesome Fun Time

Mondays from 4-5 p.m.

Thursdays and Fridays from 10:30-11:30 a.m.

A super, awesome, fun time for kids ages 10 months to 6 years with stories, songs, activities, and crafts. Space is limited. Please pick up tickets at the Childrens Room desk, starting 30 minutes before the program begins.

For more information, please contact Angie Howes by phone at 508-785-8113 or via e-mail at ahowes@doverma.org

Excerpt from:
Programs at the Dover Town Library - Wicked Local Melrose

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By JANA ALEXANDER HILLPublished December 18, 2019Monroe Y teen room gives a warm place to chill after school

Jim Scolman photo Tori Whetzel, 14, left, works on a new hairdo for a friend, 13-year-old Dannika Chandler, as other YMCA teens enjoy a game of foosball on a visit to the Monroe Ys Teen Room on Friday, Dec. 13.

MONROE The Teen Room at the YMCA is an afterschool hub, for friends to talk, or even dance it out.Its a good, safe place for them to be, said Mani Fergoso, teen coordinator at the Monroe Y.He said his program is busiest on Fridays with about 30 kids, and Monday through Thursday he gets about half that. Activities are open-ended and include socializing, video gaming, foosball and board games. Fergoso said some teens use the group-exercise rooms to blast the music and dance away afterschool stress.In the past, Fergoso structured the time afterschool in a program called Seventh Period that had homework-time required. Now, homework help is optional. Nat, a teen who wanted to give her first name only, said she has been attending for two years. Its a fun place that I can hang out with my friends, she said.Shelves hold board games, including Scrabble, Risk, Cranium and Boggle. Some kids just like to socialize, while others take a seat along the wall, and tap away on cell phones. On a Monday afternoon, about half of the kids were around a table talking and eating a snack.In Generation Z style, they are attuned to surroundings while engaging with their cell phone. Middle schoolers saunter in at about 2:30 p.m., grab a snack and find one of six seats around the table. Fergoso said they used to sell snacks, but some kids didnt have the pocket-change, so he reshaped the program to be more inclusive. Now the Sky Valley Food Bank donates snacks.Seventh grader Garrett Brindamor, 12, has been going to the teen room for two years. I like it because a bunch of my friends came here and they have games and stuff. He said if he wasnt at the teen room, hed probably just sleep after school.Eighth grader Dannika Chandler, 13, has been going for three years. She has seen the changes in how different teen coordinators operate the program. Its fun to have peoples perspective and how they run the program. She recalls a circle time with one teen coordinator, and likes the freedom of Fergosos programming.The snacks and the dining-room style experience create a family atmosphere.Fergoso has deep roots in the community and said he draws in new participants by visiting the schools. He has a relationship with teachers and counselors, so he is able to get permission to attend lunches. Thats one of the biggest ways I reach out to kids, he said.The Y offers a $20-per-month youth membership for teens under the age of 18, and a $17-per-year option for kids who are on free and reduced lunch programs, which indicates that their household lives near or below the poverty line. The front desk has information for teens who want to try it out and see if its something they enjoy.More kids filter in as the clock turns to 2:45 p.m. They arrive on shuttles that run between the schools and the Y. The transportation is a co-agreement between the nonprofit and the schools.Its a good group of kids, Fergoso said.Part of what the Y brought into Fergosos life is something he passes on to the teens. (The YMCA) taught me that higher education is possible, he said. He is now halfway through his associates degree and on the way to a career in helping people, either in general psychology or social work.This is the work that I enjoy, he said.For more information on the Monroe YMCA Teen Room, call 360-805-1879 or visit the Y at 14033 Fryelands Boulevard.

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Monroe Y teen room gives a warm place to chill after school - Snohomish County Tribune

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UGA study to examine why that's happening and how to improve the statistics

Rural communities experience more deaths each year related to poor cardiovascular health compared to city dwellers, and that gap is widening.

Now, a team of researchers from the University of Georgia and the Icahn School of Medicine at Mount Sinai are using a new, robust form of computer modeling to find ways to reduce this urban-rural divide in Georgia and New York.

The project, supported by a $1.5 million grant from the National Institute on Minority Health and Health Disparities, will use agent-based modeling to simulate the impact of real-world policy interventions. It is the first to collect data and simulate policies at the county and state levels.

Agent-based modeling was first developed to assess food environments in urban settings, said Donglan Stacy Zhang, project leader and assistant professor in UGAs College of Public Health.

The model takes into account many factors that influence individuals health behaviors, including sociodemographic factors, the local environment, and personal preferences and beliefs.

Zhang saw a need to adapt the model to work for rural and often resource-poor areas.

The places that need evidence-based policy simulations the most are areas with limited resources, she said. Rural areas do not have the resources that many urban communities have, so given scarce resources, they have a higher need for evidence to help guide their policy decisions.

Increasingly, systems science and simulation modeling are playing an important role in the selection and implementation of policies and interventions to help people improve their overall health.

Health is determined by more than individual choices, said Zhang. There is a system of clinical and community factors that contribute to cardiovascular health.

For example, provider shortages and the ability to pay for health care affect a persons access to regular care, while their community environments, such as access to heart-healthy foods and safe places to exercise, also shape lifestyle and overall health.

A model can help us understand the whole system and understand the interplay of complex factors, said Zhang.

Zhang and UGA public health collaborator Janani Thapa, recently published a study showing that the agent-based model could be successfully translated to rural communities, laying the groundwork for this larger, more ambitious study.

The current project is collecting data from federal, state and local sources, including from the Centers for Disease Control and Prevention, medical claims records, existing cohort risk scores, and local community organizations.

The focus on local data and outcomes is the unique feature of the teams simulation model, said Zhang. Many existing models with a national-level focus, she explained, are less useful in informing local policies and interventions.

Most interventions are implemented at the community level. Its really important for us to understand the local population characteristics and local environment in order to tailor interventions and improve the health of these communities, she said.

The team will evaluate the impact of improved health care delivery and community-based public health interventions on cardiovascular health. Such interventions include home telehealth for diabetes monitoring, insurance copayment reductions for highly valued services,increasing access to fresh produce, increasing tobacco excise taxes, and diet and physical activity promotion programs, said Zhang.

The investigators also want to examine the different political and economic climates that may shape health outcomes in Georgia and New York.

The two states have very different economic conditions and political values, said Zhang. So, we will look at the variation in the impact of the same policy on populations in both states.

The team has begun collecting data and will be running their first simulations in the coming months. The team members plan to roll out their findings and policy recommendations to local community leaders and state and federal policymakers throughout the four-year project.

The full project team includes Donglan Stacy Zhang, Yan Li, Janani Thapa, Lan Mu, Zhuo Adam Chen, Andrew Moran and Jos Pagn.

See the article here:
Cardiovascular deaths are higher in rural areas - University of Georgia

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Feb. 14, 2018, began like any other day for Kai Koerber. He was running late for his early morning AP English class at Marjory Stoneman Douglas High School in Parkland, Florida. When he got there, he was handed the classs biggest assignment of the year and groaned. At the time, I was like, Man, this is going to be the worst part of my day,' says Koerber, now a first-year student majoring in computer science at UC Berkeley.

After English, he had honors chemistry, followed by pre-calculus, then guitar class in the band room. At 2:18 p.m., he asked to use the restroom, but another classmate was out, so his teacher told Kai to wait. Two minutes later, the fire alarm went off. And what followed was a tragedy that his school would become known for one that Kai would decide to speak out about, changing the narrative about the impact of gun violence on youth in the United States.

At Berkeley, in between classes and studying, Kai works to promote his nonprofit and mental health curriculum something that hes become passionate about since surviving one of the deadliest school shootings in the country.

Kai Koerber is a first-year student majoring in computer science at Berkeley. (UC Berkeley photo by Brittany Hosea-Small)

[Music: Highride by Blue Dot Sessions]

Narration: It was Feb. 14, 2018. Valentines Day. Like most days, Kai Koerber was running late to AP English. To be fair, the class was at 7:30 in the morning, which, to me, seems absurdly early for a high school class.

Kai at 6 months old with his mom, Alana. Before Kai enrolled in high school, his family moved from New Jersey to Florida so that Kai and his two younger sisters could get a better education. (Photo courtesy of Alana Koerber)

But thats how it was at Marjory Stoneman Douglas High School in Parkland, Florida. It was known for rigorous classes that set students up to attend the best colleges. And Kai, whose family had moved from New Jersey so that he and his two younger sisters could get a better education, was determined to make the most of it.

And it paid off. After he graduated, he got into UC Berkeley, where hes now a first-year student majoring in computer science.

What Kai didnt know that day about his high school was that it would also become known for a national tragedy one that he would decide to speak out about, changing the narrative about the impact of gun violence on youth in the United States.

Youre listening to Fiat Vox, a Berkeley News podcast. Im Anne Brice.

Narration: When Kai got to AP English, his teacher handed him the classs biggest assignment of the year a 20-page rhetorical analysis essay.

Kai Koerber: At the time, I was like, Man, this is going to be the worst part of my day. But, you know, as the day went on, obviously that wasnt the case.

Narration: Next, he had honors chemistry, followed by pre-calculus, then guitar class in the band room his most relaxing class of the day.

At 2:18 p.m., he asked his teacher if he could go to the restroom. But one of his classmates was already out, so the teacher told Kai to wait until the student returned.

Kai Koerber: I feel like thats divine intervention, almost. I cant think of any other way to explain that, really.

Narration: Two minutes later, at 2:20 p.m., the fire alarm went off. Kai and all the other students were evacuated to a grassy field. No one was really worried. They figured it was just another emergency drill, like they had from time to time.

[Music: Zither Sprak by Blue Dot Sessions]

But one student, whom Kai says was known as the class hypochondriac, said he heard gunshots. The other students kind of laughed it off and told him to relax.

Turns out, though, that time he was right.

Within minutes, the teachers had gotten word that there was an active shooter somewhere on campus. Everyone ran back inside to take cover.

Kais teacher locked the band rooms steel doors, covered the windows and turned off the lights. Students did their best to hide in closets and behind tables.

Kai Koerber: Nobody really knew where this person was. Nobody really knew what they were armed with, what they were doing, what they were capable of. At the time, we felt like sitting ducks.

Narration: Huddled in a closet, Kai texted his parents.

Kai Koerber: I remember texting them, like, Dont call me, because I dont want them to hear if theyre in the building. If they hear that someones on the phone, that could be it for all of us. I just kept saying, I love you, and Ill see you again later. Things like that.

When Kais mom, Alana, saw that her son sent her a text on Feb. 14, 2018, she didnt think anything of it at first. But when got a moment to read it, her heart sank. (Photo courtesy of Alana Koerber)

Narration: Kais mom, Alana Koerber, was driving on the freeway when she got his text. At first, she assumed it was just one of her sons everyday texts, asking if she was picking him up from school that day.

But when she got a moment to glance at her phone, she froze.

Alana Koerber: It said, Hey, Mom. Something is happening at my school. Im not sure, but I just want to let you know that if anything happens to me, that I love you. Im like, What does he mean, If anything happens to me, just know that I love you? That just made my heart drop.

Narration: By then, she was driving on the highway. Police cars with sirens blaring began to fly past her.

Alana Koerber: And Im like, Oh, my God! I just started shaking, like panicking, just not understanding. Like, Oh, my God, something is happening! What is happening?

Narration: She called the Coral Springs Police Department. They told her there was an active shooter on the schools campus, and that they didnt have any more information.

Alana headed straight for the school, parked and ran across the street to join a group of parents. The sheriff was there. Helicopters were landing on the baseball field. SWAT teams were rolling in, and huge ambulances were racing to the scene.

Alana Koerber: And Im like, Oh, my God! Oh, my God! Oh, my God! I dont care. I want to go. Why the hell are you guys all out here? All these cops are out here. You need to be in there where the kids are to save our kids. And then, the parents around me start to receive videos of dead bodies, blood. Theyre passing their phones around. Theyre passing these videos around. And its a group of like 30, 40, 50 parents.

The crowd is growing, and were starting to cry and hug each other because our kids are still in that school. And now we have videos of dead bodies. I was praying to God. I was just saying, God, please, please, please, please God. I dont know what I have to do. I dont know what I have to sacrifice. I dont know what I have to give up. But, Lord, please get my son out of there.

[Music: Lunette by Blue Dot Sessions]

Narration: Back in the band room, Kai was doing his best not to panic. Of course, just like most students in the school, he didnt know what was going on who and where the shooter was, if anyone had been hurt, if that day would be his last.

But he did know how to stay calm through stressful situations.

Kai Koerber: I tried my best to not think the worst. When I was really stressed out in certain situations, my family always told me to picture myself being safe at all times, no matter how dangerous the situation actually is. Its really gotten me through some rough times and kept me safe in a lot of different ways.

Alana Koerber: You know, I taught my son how to metaphysically protect himself, surrounding himself with white light, picturing wings of an angel, just soothing him from harm.

After the shooting, Kai wasnt sure he wanted to do interviews with the media. But after talking it over with him mom, he decided it was important that he speak out about the impact of gun violence on youth. (Photo courtesy of Alana Koerber)

Narration: So, Kai sat perfectly still in a corner of a closet, imagining himself surrounded by a bright protective light.

And Kai and his mom say that it worked that day. He was protected. If Kais teacher had let him go to the bathroom at 2:18 p.m., like hed asked, he would have been in the exact hallway at the exact time the gunman began shooting.

After about three hours, the high school was taken off lockdown, and students were allowed to go home.

It wasnt for another day or so that Kai would learn, along with the rest of world, that 17 people had been killed 14 students and three staff members making it one of the deadliest school shootings in the country. The killer was Nikolas Cruz, a former student at the high school.

[Music: Fifteen Street by Blue Dot Sessions]

Kai would go on to become an influential voice in the fight against gun violence. He did dozens of interviews with national news shows, radio programs and magazines. He attended protests and rallies, where he spoke to reporters whenever they had questions.

It was his responsibility, he says, to share his voice and try his hardest to make a difference in the way that mental health is understood and treated in the U.S.

Kai, 16, stands outside Stoneman Douglas High School in February 2018, days after the shooting. (Photo courtesy of Alana Koerber)

Narration: After the shooting, Kai wasnt sure he wanted to be in the limelight. Other Parkland students had begun appearing on TV, speaking out against gun violence and pushing for reforms in the country.

But Kai questioned if it was right. He wondered, Should they be putting themselves out there? Was it going to create positive change, or was it sensationalizing the tragedy?

He talked it over with his mom, and decided that he wanted to add his voice to the narrative to take a stand and speak authentically about gun violence and mental health, bringing the perspective of a young black person living in the South.

Kai appeared on the Daily Show with Trevor Noah with four other Stoneman Douglas High School students in March 2018. (Photo courtesy of Alana Koerber)

Here is he on the Daily Show with Trevor Noah with four other Stoneman Douglas High School students:

[Audio from the Daily Show interview:

Trevor Noah: Kai, on your side, giving teachers guns isnt the safe space that you would want to be in. A teacher having a gun doesnt make you feel better. Why?

Kai Koerber: If Im being honest, I dont want to seem like that guy, but me being a minority in the South and having a teacher with a gun does not make me feel comfortable. Even when you have resource officers who are taking matters into their own hands, I dont think lethal weapons should have a place in the school environment. If you need to have a weapon to defend people, I do believe it should be a non-lethal option.]

Narration: Kai soon became committed to promoting mental health curriculum in schools.

In April 2018, he founded Societal Reform Corporation, a nonprofit dedicated to supporting mental health programs in schools programs that teach students of all ages to mitigate emotions, relax, learn and grow as human beings.

He teamed up with the Crown Prince of Norway and Berkeley alumnus, Haakon Magnus, who runs a program called Global Dignity. He also partnered with a leading author on mindfulness and personal transformation, Jack Canfield. (Both Magnus and Canfield had seen Kai talk at different events and contacted him about a possible collaboration.)

Kai Koerber: I have found that a lot of people who are tremendously successful or who are in those positions do share a lot of the same beliefs that I do, in terms of how mental health works the power of intention, goal setting and not letting things stand in your way, no matter what they are. It seems to be a universal language to them.

Narration: Using both Magnuss and Canfields curricula, Kai has put together what he calls his Empowerment Curriculum some 400 pages of more than 100 lessons that he says will be a growing library of self-improvement resources.

Kai Koerber: It not only counters the culture of pharmaceutical dependence that America has, in terms of regulating emotional states, but it also teaches people that they dont need to depend on things outside of themselves to live happy and healthy lives.

[Music: Greylock by Blue Dot Sessions]

That was a really big part of my upbringing and I really wanted to share that and create a curriculum that reflected those beliefs.

Narration: A big part of the curriculum teaches mindfulness exercises that help to channel positive energy and mitigate negative emotions.

For one exercise, theres a script, but the idea is that someone might look in the mirror and say something like, I can overcome any obstacle standing in my way. By channeling the power of intention, it becomes a reality.

In Kais Empowerment Curriculum, theres a section that talks about how to use meditation to center yourself in a more positive reality something that Kai tries to do every day. (UC Berkeley photo by Brittany Hosea-Small)

Narration: Kai has already donated his curriculum to several school districts in Florida and to some alternative high school programs that help high-risk youth get their GEDs. Broward County Public Schools the sixth largest public school system in the nation is looking to incorporate some of its teachings into next years lesson plans.

As a student at Berkeley, Kai plans to major in computer science. Hes always loved math and finding solutions to problems, and his family has a long history in the field. His grandfather worked on Wall Street as a mathematical statistician. His uncle worked at NASA as a rocket scientist.

Kai Koerber: Its almost a right of passage to take calculus and all those classes. (laughs)

Narration: And when he has time between classes and studying, hes speaking at events across the country about mental health and the impact of gun violence on youth.

Kai says hes always loved math and solving problems. It runs in the family his grandfather was a mathematical statistician on Wall Street and his uncle worked at NASA as a rocket scientist. (UC Berkeley photo by Brittany Hosea-Small)

In November, Kai was the keynote speaker at the Florida Gulf Coast University, Children and Youth Mental Health Conference, where he received a standing ovation after leading several exercises from his curriculum with the audience.

And earlier this month, Kai spoke at an informational hearing chaired by California Assembly Member Buffy Wicks in Oakland. He was one of more than a dozen witnesses who testified on the impact of gun violence at the California Assembly Select Committee on Youth Mental Health.

[Music: Dirty Wallpaper by Blue Dot Sessions]

Kai says, ideally, he would like to see some of the lessons in his curriculum be used in high schools right away. The lessons on goal-setting and self-improvement, he says, are essential for students as they enter more challenging chapters of their lives. Eventually, he hopes the curriculum will be incorporated into all levels of education, from elementary school to college.

Kai knows its not going to be easy, but thats never been a roadblock before. When people tell him to consider other options or to think about what could happen if something failed, he says he doesnt have the energy or time to waste.

Kai with friends Mohammed Zareef Mustafa (left), Tijaan Issah Henderson (center) and Sundiata Chaka Teooem (right) at Crossroads Dining Hall, where Kai eats most of his meals. (UC Berkeley photo by Brittany Hosea-Small)

Kai Koerber: You just keep moving forward. You know, people, theyre very confused by that belief. But I dont know. Its something that I grew up with and its something thats worked for me as a student, as an entrepreneur and as a person. So I think Ill carry it with me for the rest of my life.

Narration: Kai continues to build new partnerships to grow his curriculum. He recently secured partnerships with two neurotechnology companies that create devices for focus, relaxation and guided meditation. He hopes to install neurotech lounges on campus that use real-time biofeedback to promote relaxation and focus.

At only 18, Kai has already accomplished a lot, but I have a feeling, its just the beginning.

For Berkeley News, Im Anne Brice.

To learn more about Kais nonprofit, Societal Reform Corporation, visit societalreform.org/. If you work at a school or for an after-school program and are interested in using the Empowerment Curriculum, email info@societalreform.org.

Subscribe to this podcast, Fiat Vox, on Apple Podcasts or wherever you listen. If you liked this episode, consider sharing it with a friend. And check out our other podcast, Berkeley Talks, that features lectures and conversations at UC Berkeley. You can find all of our podcast episodes on Berkeley News at news.berkeley.edu/podcasts.

(UC Berkeley photo by Brittany Hosea-Small)

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After Parkland shooting, student fights for mental health resources in schools - UC Berkeley

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Collaboration Combines GBTs Therapeutic Area Leadership with Power of SyrosGene Control Platform to Find New Medicines to Induce Fetal Hemoglobin

Syros to Receive $20 Million Upfront, Three Years of Preclinical Research Fundingand Milestone Payments

SOUTH SAN FRANCISCO, Calif. and CAMBRIDGE, Mass., Dec. 18, 2019 (GLOBE NEWSWIRE) -- Global Blood Therapeutics, Inc. (GBT) (GBT) and Syros Pharmaceuticals, Inc. (SYRS) today announced that they have entered into a collaboration to discover, develop and commercialize novel therapies for sickle cell disease (SCD) and beta thalassemia. Under the agreement, Syros will use its leading gene control platform to identify therapeutic targets and discover drugs that induce fetal hemoglobin, and GBT will receive an option to obtain an exclusive worldwide license to develop, manufacture and commercialize products resulting from the collaboration.

The discovery and development of novel therapeutic approaches to treat sickle cell disease has been a driving force for GBT since we were founded, said Ted W. Love, M.D., president and CEO of GBT. We believe that Syros approach to inducing fetal hemoglobin is one of the most promising ways to identify the next generation of therapies to treat sickle cell disease and beta thalassemia at a fundamental level upstream of serious complications such as organ damage, organ failure and early death. We will continue to seek the best scientific approaches to transform the treatment of these devastating lifelong diseases.

Using its gene control platform to elucidate mechanisms controlling gamma globin gene expression, Syros identified components of LRF (leukemia/lymphoma-related factor) and the NuRD (nucleosome remodeling and histone deacetylation) complex that could serve as potential targets to switch on the gamma globin gene, which is normally silenced a few months after birth. By turning on gamma globin expression, GBT and Syros aim to induce the production of fetal hemoglobin, which is known to exert protective effects on the red blood cells of patients with SCD and beta thalassemia and mitigate the clinical manifestation of these diseases.We believe it is possible to provide a functional cure for patients with sickle cell disease or beta thalassemia by switching on the gamma globin gene with an oral medicine, said Nancy Simonian, M.D., CEO of Syros. Partnering with GBT, an established leader in sickle cell disease with proven research, development, manufacturing and commercialization capabilities, allows us to expand and accelerate our program, exploring multiple approaches in parallel with the aim of bringing much-needed new therapies to market for patients with sickle cell disease and beta thalassemia as quickly as possible.

Syros drug discovery program in SCD was highlighted recently in an oral presentation at the 61st American Society of Hematology (ASH) Annual Meeting, as well as in an ASH press briefing. In that presentation, Syros described its discovery of a fetal hemoglobin repressor that, when knocked down in primary cells and an erythroid cell line expressing adult hemoglobin, induced fetal hemoglobin in nearly 100% of cells and increased total fetal hemoglobin levels to 40%, exceeding levels that are associated with a functional cure in SCD patients.

Terms of the AgreementUnder the terms of the agreement, GBT will pay Syros $20 million upfront and fund up to $40 million in preclinical research for at least three years. Should GBT exercise its option under the agreement, Syros could receive up to $315 million in option exercise, development, regulatory, commercialization and sales-based milestones per product candidate and product resulting from the collaboration. Syros would also receive mid- to high-single digit royalties on sales of products resulting from the collaboration. In addition, Syros would have the option to co-promote the first product resulting from the collaboration in the United States.

About GBTGBT is a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. Founded in 2011, GBT is delivering on its goal to transform the treatment and care of sickle cell disease (SCD), a lifelong, devastating inherited blood disorder. The company has introduced Oxbryta (voxelotor), the first FDA-approved treatment that directly inhibits sickle hemoglobin polymerization, the root cause of SCD. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. In addition, GBTs drug discovery teams are working on new targets to develop the next generation of treatments for SCD. To learn more, please visit http://www.gbt.com and follow the company on Twitter @GBT_news.

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About Syros PharmaceuticalsSyros is redefining the power of small molecules to control the expression of genes. Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. Syros is advancing a robust pipeline of development candidates, including SY-1425, a first-in-class oral selective RAR agonist in a Phase 2 trial in a genomically defined subset of acute myeloid leukemia patients, and SY-5609, a highly selective and potent oral CDK7 inhibitor in investigational new drug application-enabling studies in cancer. Syros also has multiple preclinical and discovery programs in oncology and monogenic diseases, including sickle cell disease. For more information, visit http://www.syros.com and follow us on Twitter (@SyrosPharma) and LinkedIn.

Forward-Looking StatementsCertain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995, including statements containing the words will, anticipates, plans, believes, forecast, estimates, expects and intends, or similar expressions. These forward-looking statements are based on the current expectations of GBT and Syros, and actual results could differ materially. Statements in this press release may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. GBT and Syros each intend these forward-looking statements, including statements regarding the ability of the parties to discover, develop and commercialize novel therapies for SCD and beta thalassemia under the collaboration, the scientific and therapeutic potential of Syros gene control platform and approach to inducing fetal hemoglobin, the exercise by GBT of its option under the collaboration agreement, the potential milestone payments and royalties due to Syros under the collaboration agreement, and Syros option to co-promote the first product resulting from the collaboration in the United States, to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Securities Exchange Act, and GBT and Syros make this statement for purposes of complying with those safe harbor provisions. These forward-looking statements reflect the current views of GBT and Syros about their respective plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the companies and on assumptions the companies have made. Neither GBT nor Syros can give any assurance that the plans, intentions, expectations or strategies will be attained or achieved, and, furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a variety of risks and factors that are beyond the control of GBT and Syros including, without limitation, the timing and progress of, and any data generated from, the parties research and development activities under the collaboration, and the amount and timing of resources devoted by each of the parties to activities under the collaboration, along with those risks set forth in GBT and Syros respective Annual Reports on Form 10-K for the fiscal year ended December 31, 2018, and most recent Quarterly Reports on Form 10-Q filed with the U.S. Securities and Exchange Commission, as well as discussions of potential risks, uncertainties and other important factors in the companies subsequent filings with the U.S. Securities and Exchange Commission. Except as required by law, neither GBT nor Syros assumes any obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.

Contact Information:

Global Blood Therapeutics (GBT)

MediaSteven Immergut650-410-3258media@gbt.com

InvestorsStephanie Yao650-741-7730investor@gbt.com

Syros Pharmaceuticals

MediaNaomi Aoki617-283-4298naoki@syros.com

InvestorsHannah Deresiewicz212-362-1200hannah.deresiewicz@sternir.com

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GBT and Syros Partner to Discover, Develop and Commercialize Novel Therapies for Sickle Cell Disease and Beta Thalassemia - Yahoo Finance

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In the world of at-home workout programs, Beachbody reigns supreme. Its various workouts range from 21 Day Fix, P90X, 3 Week Yoga Retreat, Country Heat...the list goes on. Beachbody programs allow you to kick your own butt into stellar shape from the comfort and anonymity of your living room, so its no surprise the programs are so popularor that the company is constantly adding to their fitness catalog.

Which brings us to 80 Day Obsession, created by Beachbody super trainer Autumn Calabrese. Her newest program promises big wins in a short period of time (a 9-pound weight loss in as little as 14 days, along with major shredding down the line) by laying out an ultra-specific plan comprised of 30- to 60-minute workouts and well-timed macronutrient meals.

But is 80 Day the right fitness and diet plan for you? Well, that depends. WH asked personal trainers and a registered dietitian what they think about the plan. Plus, Calabrese herself weighed in how she designed the plan, who she had in mind, and what she really thought about that word obsession the first time she heard it.

80 Day Obsession is a weight-loss program designed primarily for people who have a basic foundation of fitness. In other words, if youre stalling out on your current exercise routine and want to kick your results up a notch, 80 Day Obsession could be just what you need to really take charge of your weight and overall health.

There are two components to the program: the fitness regime and the timed nutrition meal plan. Some basic equipment is required, like weights and resistance bands, and there are different package options ranging in price from $39 to $160 (sometimes there are discounts available).

The exercise program lasts for 13 weeks and is split up into three different phases, each one four weeks long. At first, you work on building basic strength and balance, explains Calabrese; as you move through the phases, you start to work up to more complex movementsto work up to building more muscle massand then finally start tackling power movements for optimal shredding.

We decided to throw in that final thirteenth week as a peak week, which is something we do in the competitive world, explains Calabrese. Thats the week you get your best results.

If that all sounds fairly straightforward for a three-month fitness plan, it basically is. The big thing to know up front is that these workouts are intense right from the start. Each one lasts anywhere from 30 to 60 minutes, and you work out for six days before taking a rest day. Whats more, each workout is designed to tackle a different area of fitness (like butt, legs, core, and cardio), and every week your workout gets changed up to really challenge you from one phase to the next.

I dont want people to plateau or get bored, so you never really do the same workout twice, says Calabrese. Every week youre getting something different, pushing faster and harder.

As long as youre not pushing yourself beyond your actual physical limitations, taking on a program like 80 Day Obsession can be a great way to see quick progress and to really push yourself.

The structure of the program works because you rest different muscle groups by varying your exercises daily and then getting a day of full rest, says Lynell Ross, a certified personal trainer and health and wellness coach, who adds that the six days of super varied exercise routines allows you to easily achieve new levels of fitness.

What does the 80 Day Obsession meal plan involve?

Calabrese says she always has a nutrition component included in all of her Beachbody programs, and 80 Day Obsession is no exception. And if youve ever done one of her other programs before (like 21 Day Fix), a lot here will be familiar to you.

Even if you havent done any of Calabreses programs, the nutrition piece is pretty simple: It utilizes color-coded containers (that you can buy on the Beachbody website) for different macronutrientssuch as carbs, protein, and fatsand youre generally allowed to eat what you want from your days containers at any meal.

80 Day Obsession also incorporates something called timed nutrition, where youre instructed to eat specific foods, or combinations of foods, at specific times of the day. Youre also encouraged to eat every three hours or so to avoid getting too hungry and overeating.

Basically, Calabrese's focus is on filling your diet with:

40/30/30 is a well-balanced ratio of nutrients, particularly for active people, says Danielle Schaub, RD, culinary and nutrition manager for Territory Foods. The average American diet consists of 50 percent carbs, 15 percent protein, and 35 percent fat, which is a little low on protein for most people who exercise regularly and need additional protein to repair and build muscle.

As far as the timed nutrition side of things, Schaub says that, depending on your personal goals, it can have a powerful impact on your healthbut its important to remember that weight loss can only be achieved when total calories consumed are less than the energy you expend. (In other words, when combined with a healthy diet, timed nutrition can help you control your hunger, avoid overeating, and maximize your workout efforts...but it wont make you lose weight all on its own.)

According to our experts, 80 Day Obsession features some strong qualities on both the fitness and nutrition sides.

What are the cons to consider?

There are a couple of potential downsides or challenges to keep in mind about the plan.

On that last note, Calabrese herself would have loved to see the program named something else, too. "I had the exact same feeling about the negative association with that word, she admits. Ultimately, though, Calabrese realized that its just a wordand she could make it a positive one, if she tried.

After all, it does require a certain amount of obsession to maintain a healthy level of fitness in your life. We hear that word and want it to be negative, but we get obsessed with things like TV shows all the time...why cant we be obsessed with being happiest, healthiest version of ourselves?

Okay...but should I try 80 Day Obsession?

If you are: injury-free and in good health, do not have a history of disordered eating, understand the basic principles of warming up, cooling down, and using proper formyou should be good to go.

When Calabrese first designed the program, she didnt intend for it to be used by people who had zero experience with working out or who wanted to lose a significant amount of weight. Though some people have had success jumping into 80 Day Obsession with little to no experienceand crushing their goals in the processits generally recommended that you have a baseline level of workout experience before getting started.

The reason for that really comes down to safety. A good candidate for the 80 Day Obsession Plan is a person looking for a challenging work out, but definitely not for beginners, says Ross. People can get hurt easily when they go beyond their level of fitness too quickly.

Roser agrees. This program is perfect if youve been working out consecutively for about three months, doing [strength and cardio a few times per week], she advises. It requires explosive movements and is a high intensity workout geared for people who have been conditioned to handle fast-paced movements with little recovery time.

Ultimately, if you've tried and liked Beachbody programs in the past, you'll probably be a fan of the 80 Day Obsession Planand you'll crush it! But if it sounds too restrictive for you and unsustainable, pass on this particular plan for something that better fits your lifestyle.

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What Is 80 Day Obsession And Can It Help You Lose Weight? - Women's Health

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