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Diet soda once ruled the weight loss kingdom but unfortunately, that time has swiftly passed. At this point, these sweet beverages should come with a warning label. Not only are they one of the worst drinks for diabetics, but diet sodas can also take a serious toll on your brainand the health hazards dont stop there.

A newstudypublished in Current Biologymay convince you to finally drop the pop.According to the researchers, there could be a sweet spot (haha) when it comes to those artificial sweeteners in diet soda.

For the experiment, Yale neuroscientist Dana Small designed five beverages, all of which were sweetened using the identical amount of sucralose, an artificial sweetener. Although each tasted about as sweet as a drink containing about 75 calories of sugar, Small varied the calories using a tasteless carbohydrate called maltodextrin. Each drink contained zero, 37.5, 75, 112.5, 150 calories.

Participants consumed each drink six times over a period of several weeks, twice in the lab and four times at home. Small then evaluated their brain scans to determine how each drink affected the brains reward mechanisms.

Logically, higher calorie counts should yield higher rewards in the brain. But contrary to expectations, the participants brains signaled the highest rewards for the 75-calorie drinkhigher than the 0-calorie drink and the 150-calorie drink. Whats more, their metabolic responses to the high-calorie drink were lower than for the medium-calorie drink. What gives?

As it turns out, sweetnessnot caloriesdetermines the bodys response to food. When sweetness and calories are matched, as with the 75-calorie drink, the bodys reward mechanism and metabolic rate actnormally. Butthe body becomes confused when it tries to digest something that has higher or lower calorie count relative to its sweetness.

Its like the system threw up its hands and didnt know what to do, Small told Vox.

Withyour metabolism thrown for a loop, its likely that the extra calories arestored in muscle, fat, or the liverall of which is pretty bad news. (And if you want to lose weight,avoid this one food at all costs.)

Equally worrisomeis that more and more companies are creating foods that contain blends of sweeteners and carbohydrates, Vox reports. That goes for diet sodas as well as sports drinks like Powerade, which, as Small notes in her paper, contains bothsugars and artificial sweeteners.

Yep, youll definitely want to toss out those soda cansASAP. Your body will thank you.

Link:
Drinking Diet Soda Will Ruin Your Metabolismand Could Make You Gain Weight - Reader's Digest

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Whats President Donald Trumps biggest strategic blunder on North Korea? In the estimation of one former Department of Defense official, its a surplus of male hormones.

Appearing on MSNBC Monday, Deborah Lee James who served as Secretary of the Air Force under President Barack Obama called on Trump to pursue diplomatic options with North Korea.

I would tell him to tone down the bluster and the rhetoric from the top, James said. And work with these new sanctions that we have both China and Russia on board to enforce. And ensure that the enforcement happens in an air-tight fashion. Double down on diplomacy.

Then, in closing, she added, Lets tone back the testosterone.

Trump, of course, ratcheted up the rhetoric on North Korea last week in a series of statements to the media and on Twitter. Most notably, Trump warned he would unleash fire and fury on North Korea if they escalated their nuclear threat.

North Korea best not make any more threats to the United States, Trump said. They will be met with fire and fury like the world has never seen.

Watch above, via MSNBC.

[featured image via screengrab]

Follow Joe DePaolo (@joe_depaolo) on Twitter

Have a tip we should know? tips@mediaite.com

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Fmr. Air Force Secretary: Trump Needs to 'Tone Back the Testosterone' - Mediaite

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Testosterone therapy has been advocated in the treatment of symptoms that may represent normal aging. We briefly review randomized clinical trials on the effects of testosterone therapy on sexual function.

About half of clinical trials showed no benefit of testosterone therapy on any aspect of sexual function. In those studies showing a benefit on some aspect of sexual function, most sexual function domains were not improved. Testosterone therapy has been disappointing in the treatment of erectile dysfunction. Potential risks of therapy include an increase in thromboembolic and other cardiovascular diseases.

The limited and inconsistent benefits of testosterone therapy for sexual function argue against use of this therapy in aging men, including those with 'low testosterone'.

Current opinion in urology. 2017 Aug 08 [Epub ahead of print]

Adriane Fugh-Berman, Anthony R Scialli

aDepartment of Pharmacology and Physiology, Georgetown University Medical Center bDepartment of Obstetrics and Gynecology, George Washington University School of Medicine, and Scialli Consulting LLC, Washington, District of Columbia, USA.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/28795961

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Testosterone and sexual function. - UroToday - UroToday

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SALT LAKE CITY, Aug. 14, 2017 (GLOBE NEWSWIRE) -- Lipocine Inc. (NASDAQ:LPCN), a specialty pharmaceutical company, today announced that the U.S. Food & Drug Administration (FDA) has acknowledged receipt of the Companys New Drug Application (NDA) resubmission for TLANDO, its oral testosterone product candidate for testosterone replacement therapy (TRT) in adult males for conditions associated with a deficiency of endogenous testosterone, also known as hypogonadism. The FDA has deemed the resubmission a complete response to its June 2016 Complete Response Letter (CRL) that requested additional information related to the dosing algorithm for the proposed label. The FDA has assigned a new Prescription Drug User Fee Act (PDUFA) goal date of February 8, 2018. The TLANDO NDA is based on the results of the Dosing Validation (DV) study. The DV study confirmed the efficacy of TLANDO with a fixed dose regimen without need for dose adjustment. TLANDO was well tolerated upon 52week exposure with no reports of drug related Serious Adverse Events (SAEs).

The FDA's acceptance of the TLANDO NDA resubmission brings us one step closer to providing an innovative oral testosterone replacement treatment option to patients. We believe TLANDO addresses a significant unmet medical need for men with hypogonadism," said Dr. Mahesh Patel, Chairman, President and Chief Executive Officer of Lipocine.

About Lipocine

Lipocine Inc. is a specialty pharmaceutical company developing innovative pharmaceutical products for use in men's and women's health using its proprietary drug delivery technologies. Lipocines clinical development pipeline includes three development programs TLANDO, LPCN 1111 and LPCN 1107. TLANDO, a novel oral prodrug of testosterone containing testosterone undecanoate, is designed to help restore normal testosterone levels in hypogonadal men. TLANDOwas well tolerated and met the primary efficacy end-points in Phase 3 testing with twice daily dosing and is currently under FDA review. LPCN 1111, a novel oral prodrug of testosterone, originated and is being developed by Lipocine as a next-generation oral testosterone product with potential for once-daily dosing and is currently in Phase 2 testing. LPCN 1107 is potentially the first oral hydroxyprogesterone caproate product candidate indicated for the prevention of recurrent preterm birth and has been granted orphan drug designation by the FDA. An End of Phase 2 meeting with the FDA has been completed. For more information, please visit http://www.lipocine.com.

Forward-Looking Statements

This release contains forward looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and include statements that are not historical facts regarding Lipocines product candidates and related clinical trials and the FDA review process relating to its product candidates, our belief that we have addressed the CRL deficiency, the expected timing of the FDA review process related to our resubmitted NDA, the path to approvability by the FDA of Lipocines development programs, the potential uses and benefits of our product candidates, and our product development efforts. Investors are cautioned that all such forward-looking statements involve risks and uncertainties, including, without limitation, the risks that the FDA will not approve any of our products, risks related to our products, expected product benefits not being realized, clinical and regulatory expectations and plans not being realized, new regulatory developments and requirements, risks related to the FDA approval process including that the FDA will determine there are deficiencies in our resubmitted NDA, risks related to the possibility of an advisory committee meeting related to TLANDO, the receipt of regulatory approvals, the results and timing of clinical trials, patient acceptance of Lipocines products, the manufacturing and commercialization of Lipocines products, and other risks detailed in Lipocines filings with the SEC, including, without limitation, its Form 10-K and other reports on Forms 8-K and 10-Q, all of which can be obtained on the SEC website at http://www.sec.gov. Lipocine assumes no obligation to update or revise publicly any forward-looking statements contained in this release, except as required by law.

Link:
Lipocine Announces FDA Acknowledgement of TLANDO (LPCN 1021) NDA Resubmission; PDUFA Goal Date ... - GlobeNewswire (press release)

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ONTARIO, Calif., Aug. 8, 2017 /PRNewswire/ -- For those looking to quickly, safely lose weight and improve their health markets, Body & Mind Medical Weight Loss Center (http://www.bodyandmindontario.com/) offers the KE Diet as part of its innovative Jump Start to Health program. This medically supervised intervention has already helped patients achieve tremendous results; more information about the program is available by calling 844-695-4331.

"Burning fat is key to losing weight and reversing lifestyle diseases like hypertension and type 2 diabetes," says Dr. Tanya Scurry, founder and medical director of Body & Mind Medical Weight Loss Center, "and the KE Diet has proven to be the best and safest way to turbocharge the fat-burning process. That's why it's an important element of our Jump Start to Health program. At Body & Mind Medical Weight Loss Center, we're helping people embrace a better way of life."

The KE Diet is administered during the first 10 days of the Jump Start to Health program. Patients receive a complete education on the diet during their intake and throughout the program. Under local anesthesia, a small naso-gastric tube is inserted to continuously deliver a specially formulated feeding solution rich in protein and fat. An obesity medicine physician closely monitors the patient throughout the diet, with no less than three follow-up appointments. Lab tests before and during the KE Diet ensure patient safety by checking electrolyte levels, ketones and other important markers.

Originally developed in Italy, the KE Diet has helped hundreds of thousands of people lose significant amounts of weight in a short time. At Body & Mind Medical Weight Loss Center, a 56-year-old male with hypertension, high cholesterol and an increased amount of abdominal fat shed 22 pounds in only ten days.

The KE Diet works by forcing the body to burn fat rather than carbohydrates for energy. The feeding solution has zero carbs, which acts as a "hard reset" for the body. While carbs are an important part of a balanced diet, the standard American diet of today suffers from an excess of this macronutrient. Simple, highly palatable carbs are especially a problem. Many preventable health issues are a direct result of excess fat and obesity caused by carb-rich diets. The 12-week Jump Start to Health program offers the tools and resources to learn healthier food choices and eating habits.

To qualify for the KE Diet, patients must have a body mass index (BMI) over 30, or over 27 with a medical condition related to obesity sleep apnea, high cholesterol, high blood pressure, etc. Patients of normal weight but high body fat percentages (over 25 percent for men, 32 percent for women) may also participate.

Once the KE Diet portion of the Jump Start to Health program concludes, patients work with a registered dietitian to develop a personalized meal plan to sustain their progress and set them on a path for a lifetime of better health. Patients also receive a personal fitness assessment by a personal trainer. The goal, according to Dr. Scurry, is to be successful in fat loss, not just weight loss.

About Body & Mind Medical Weight Loss Center

Under the leadership of Dr. Tanya Scurry, the goal of Body & Mind Weight Loss Center is to provide a helping hand to those struggling with obesity, to provide an ear to listen to their pain, to lift them up in encouragement and support, and to provide a safe place for them to heal.

Contact:

Dr. Tanya Scurry909-443-5191165841@email4pr.com

View original content with multimedia:http://www.prnewswire.com/news-releases/body--mind-medical-weight-loss-centers-jump-start-to-health-program-delivers-visible-results-with-10-day-medically-supervised-ke-diet-300500939.html

SOURCE Body & Mind Medical Weight Loss Center

http://www.bodyandmindontario.com

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Body & Mind Medical Weight Loss Center's Jump Start to Health Program Delivers Visible Results With 10-Day ... - PR Newswire (press release)

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No, we dont mean you should wake up and eat a slice of leftover cold pizza. Sorry. (Though a freshly baked breakfast pizza sounds like a great idea.)

We just mean you should swap the sizes of your meals. Its a common mistake Americans often eat little to nothing of nutritional value at breakfast and throughout the day and then go absolutely ham at dinner time. Either they go out to dinner and consume thousands of greasy, decadent calories under the misguided guise of Ive been good all day! or they sit down to a bountiful family meal that lasts long enough to go back for seconds or maybe even thirds.

This is a problem. When did we start to think it was a good idea to go hungry when we need our energy most and then make up for it with excess under the canopy of night?

Multiple studies have shown that the healthier choice is a larger and more nutritionally dense breakfast, rather than a skimpy one. Participants in these studies who ate larger breakfasts ended up eating a smaller dinner.

These larger breakfasts effectively combat the vicious restrict-binge cycle that many dieters find themselves whirling through each day: They eat small amounts of food until their cravings take over and they allow themselves to eat. Then, they inevitably overdo it when the body sets off alarmed warnings of eat what you can now before its gone; they then wake up the next morning feeling guilty and prone to restricting their intake again.

While the exact impact of the big breakfast on health is still a point of significant contention, it undoubtedly breaks the cycle by starting the day with a large, satisfying amount of food.

With the exception of night shift workers and night owls, the majority of people are most active during the day. Giving your body energy when it needs to use it is bound to have beneficial health outcomes including, if your body has a lower set point, weight loss. Your set point is the weight and size at which your body functions its best. When you eat healthy and get a moderate amount of exercise, your weight will waver around this set point your bodys happy place.

So the healthier habit of stopping the binge-restrict cycle in its tracks could totally result in weight loss that is, of course, if you need to lose weight at all. Many people deemed overweight by faulty measuring systems such as BMI actually just have a higher set pointand are healthier at that higher weight. Even an obese person can be healthier at a higher weight.

There are multiple reasons to try eating a big breakfast that have nothing to do with weight loss. In fact, big breakfasts have been shown to prevent a number of conditions including Type 2 diabetes, heart disease, and high blood pressure. One study from Tel Aviv University confirmed it by feeding 700-calorie breakfasts to study participants and observing health benefits that far exceeded expectations. The large breakfast group even experienced lower levels of bad cholesterol. They probably avoided these cholesterol-heavy breakfasts, though and you still should, too.

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Eat Dinner for Breakfast If You Want to Lose Weight - The Daily Meal

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Larry R. Miller, For the Headlight Published 2:23 p.m. MT Aug. 14, 2017

Columnist Larry R. Miller(Photo: Courtesy Photo)

This summer we have been camp hosting at an Oregon Trail day use visitor park. For my daily exercise I usually walk the 3 mile loop to open the gate, go up to the turn around and around the main trail twice a day rather than drive. A lot of my walking time is spent at a very brisk pace but I walk not only for the exercise but also to commune with nature.

Recently I read an article by Dr. Aaron Baggish an associate director of the Cardiovascular Performance Program at Harvard-affiliated Massachusetts General Hospital in Boston. In the article he gave some advice on how to dramatically increase the health benefits of walking.

His advice: Try interval walking.

When interval walking was compared to regular walking, researchers found that 30 minutes of interval walking four days a week greatly benefitted overall health through improved aerobic fitness, lowered blood pressure, reduced weight and increased leg strength.

He says interval walking is a great way to get the most exercise bang for your buck. It improves endurance, reduces blood pressure and helps with weight loss.

In a decade long study, Japanese researchers have been studying the benefits for seniors of interval walking for over a decade. Researchers from the Shinshu University Graduate School of Medicine split 696 men and women between the ages of 58 and 72 into two groups. Both groups walked four days a week for thirty minutes a day.

Researchers had one group walk normally at 40% of their full exertion for three minutes. Then they had them speed up to a 70% exertion rate for three minutes. The walkers repeated these intervals five times for 30 minutes total.

The other group walked at a leisurely 40% exertion rate for the entire 30 minutes.

After five months, the researchers compared the two groups for overall fitness, health and weight loss.

Participants who walked casually showed very little improvement. The interval-walking group showed a 12% increase in aerobic fitness, their blood pressure went down 13% and they had greater overall leg strength.

The interval walkers also decreased their overall lifestyle-related disease score. (LRDS) LRDS is a marker related to smoking, drinking, body fat ratio and weight. The interval walkers reduced their unhealthy habits, lost fat and gained muscle mass. (This never appeared in the information but I would guess they also increased their bone density and improved their balance which would decrease the likelihood of a fall and broken bones.)

The researchers continued to follow the participants for a decade longer. They found that the interval walkers even those who decreased the regimen to three days a week maintained or increased their health gains. The study was published in the Journal of Applied Physiology.

Next week I will cover how to interval walk for maximum health benefits.

Larry R. Miller is a freelance writer and photographer working with the US Forest Service. Contact him at larryrmiller@mail.com, use Headlight article in the subject line to not end up in the spam.

Read or Share this story: http://www.demingheadlight.com/story/news/2017/08/14/lose-weight-feel-great-budget/566344001/

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Lose weight, feel great on a budget - Deming Headlight

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The ketogenic keto diet has become incredibly popular in recent years as it focuses on eating plenty and not restricting meals in the same way as other meal plans tend to do.

The diet does involve limiting carbs to 50 grams or less, which puts the body into a state of ketosis, when the body turn to ketones to create energy.

Talking about the plan, Carol Johnston, professor and associate director of the nutrition program in the School of Nutrition and Health Promotion at Arizona State University, revealed how it works and whether she thinks it is a sensible diet to follow.

The science behind the keto diet claims followers must consume a high fat, low carb diet, similar to the Atkins Diet.

Discussing whether she thinks this is sensible, Prof. Johnston said: There is mounting evidence that suggests calorie restricted, low-carbohydrate, high-protein diets are effective for weight loss, and the keto diet is an extreme version of this.

Low-carb diets can be more satiating, allowing dieters to feel full longer, eat less, and thus experience greater weight loss success.

Speaking to medicalxpress.com, she continued: Overwhelmingly, the most important factor in weight loss success is diet adherence. In research trials, most individuals who lose weight regain most of it within a year, regardless of which diet they were on.

Explaining the science behind the diet, Prof. Johnston said: When carb intake is restricted for a few days, glycogen stores in the muscle are reduced. Glycogen is responsible for water retention, so when its levels fall, so do our water levels.

However, she point out, since most of this weight lost is water weight, it will return when the person consumes carbs again.

But despite her assertion that the keto diet mostly encourages water weight to begin with, Prof. Johnston did admit restricting carbs is a good idea for weight management.

She said: When we eat more carbs than we need, they convert to body fat, which contributes to obesity.

In general, average Americans those with a relatively sedentary lifestyle consume more carbs and calories than they actually need.

Another expert who has spoken positively about the keto diet is Susie Burrell, a dietician and nutritionist with two Honours degrees in Nutrition & Dietetics and Psychology.

She has told dieters that there are many benefits to the keto diet plan.

She wrote for news.com of the keto diet: With their superior weight loss and associated reductions in inflammation in the body, there are a number of benefits, particularly for individuals with high blood glucose levels, fatty liver and significant amounts of weight to lose.

She also said: There is no evidence to show that keto diets are damaging to the body.

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Weight loss: How to lose weight by eating MORE with this diet plan - Express.co.uk

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Its definitely good to hear that it takes most people longer than five weeks to drop 10 pounds (you're not alone if the scale seems stuck!), and that its also doable within three months or so. But if youre trying to drop 10 pounds, its important to keep this in mind: Everyone moves at their own pace.

There are calculations to predict the calorie deficit needed for someone to lose a pound of weight. However in reality, people lose weight as different rates, says Beth Warren, R.D.N., founder of Beth Warren Nutrition and author of Living a Real Life With Real Food. Fatima Cody Stanford, M.D., instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital, agrees. Its not the rate of weight loss that matters, per se, she says. Its the sustainability of the weight loss. People who are obese, for example, might lose weight at a very fast rate, she says, while others with less excess weight to lose may move at a slower paceand the actual rate doesnt matter as much as someones ability to keep the weight off.

While its tempting to want to drop weight quickly, Warren says its important to manage your expectations and go about it in a smart, healthy way. Losing weight through unhealthy methods could just burn off water and muscle weight, which youll quickly gain back, she says.

Scott Keatley, R.D., of Keatley Medical Nutrition Therapy, recommends starting with small changes before moving on to a new challenge. For example, you might want to try eliminating your late-night snacking habit and adding a serving of vegetables to every meal before trying an entirely new diet plan. "Many patients want to do everything all at once to lose the weight but it's generally not feasible and people give up after a brief period of time only to gain more weight back," he says.

Check out some of the weirdest weight-loss trends through history:

If youre not losing at the pace youd like, Warren says theres likely somethingor several thingstripping you up. I often find with clients that they may not be losing as fast as they can because of small allowance they are making, she says. That can mean having portions that are too large, eating pasta or bread at all meals and during a snack, eating too much later in the day or at night, or treating yourself too often. Typically, if someone is already trying to lose weight, there isn't one glaring issue, she says. Instead there may be multiple small points to adjust over the course of the day concerning their diet.

Whatever youre trying to do for weight loss, Stanford says its important to make sure that its sustainable. Often patients will say that they want to try a certain diet or exercise plan, but I say that if this works for you, youre going to have to do it for the rest of your life, she says. Losing weight on a special diet only to regain it can put your body at a higher set point for weight, she explainsand that can make it even harder to lose it all again. Its important to ask, is this going to be sustainable indefinitely? If not, reconsider the approach, Stanford says. Make sure its something you can continue forever.

If youve already lost the weight and want to make sure you keep it off, Warren recommends keeping a food log and striving to work out regularly. The reality is that after you lose the weight you want you look to be more flexible on food choices, she says. By keeping a food log, it keeps you on track to notice when you are allowing yourself too many less healthful choices or bigger portions too often. Working out regularly also helps you balance out your flexible food choices without making you feel guilty for it, she says.

Of course, people lose weight at different paces. If you notice that a friend is losing at a faster rate than you, dont get discouragedyoull get there eventually, too, and doing it your way will help you keep it off.

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This Is How Long It Takes Most People To Lose 10 Pounds - Women's Health

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MEDIA DRUM WORLD

Frances Carpenter was raised by her doting single mum who spoilt her with food.

The 28-year-old indulged on greasy takeaways, crisps and sweets until she hit 23st 9lbs and ballooned to a dress size 26.

The software support engineer from California, US, never felt satisfied and was always haunted with self-esteem issues.

But one day she began experiencing pre-diabetic symptoms such as fatigue, blurred vision and frequent urination which shocked her into changing her lifestyle.

Take a look at these exceptional body transformations.

1 / 30

Elora Harre, 23 has lost eight stone

After a complete U-turn in her diet and exercise routine Frances is now a slender 14st 8lbs and dress size 14-16.

She went from consuming over 2,000 calories a day to 1,600 a day, while started eating balanced meals and practicing portion control.

I was an emotional eater to put it lightly

Frances said: I have seen members of my family lose their life because of their weight and weight-related health issues, I just didnt want that to be me.

I have been overweight throughout my entire life from adolescence to my teen years; always turning to food as comfort for anything that didnt go my way.

I was an emotional eater to put it lightly.

"I went through high school overweight and by my last year of high school, I was around 17st 12lbs."

MEDIA DRUM WORLD

She continued: The way I grew up, my childhood was not the easiest; being raised by a single parent.

"Never having a father figure around I think contributed to most of my weight gain.

When I was younger, my mother never told me no, I think mostly out of guilt, she felt bad for our upbringing and food made me happy.

It wasnt right but at that point she was just doing anything to try and keep me smiling. I was really trying to fill a void in my life with food.

Even at a young age, I recognised something was missing and I wanted to fix it, I just didnt know how.

As much as she tried to shake the lonely feeling she had by over-eating, nothing was working and a voice in her head kept telling her there was no point trying to lose weight.

But after her health scare, Frances joined CrossFit a fitness programme dedicated to helping people improve their workout routines.

Frances explained: I couldnt sit and wait for some miracle any longer, I just had hit rock bottom and knew I needed to fix it and fast or it was only going to get worse.

I joined a Crossfit gym that completely changed my workout routine.

Crossfit incorporates every type of workout including cardio, weightlifting, gymnastics, and strength training all at different intensity levels.

MEDIA DRUM WORLD

After growing up eating nothing but fast food, crisps and sweets, the weight loss process proved to be difficult for France but she soon felt better than ever.

She said: The hardest thing for me was the food; living my life one way, always eating whatever I wanted and never thinking whats good or bad for me then all of a sudden - a drastic change.

I was eating different foods, but my mind was still wanting to eat the way I used to.

"Changing my mindset was extremely hard, I am still working on it, but its a lot better than it was."

MEDIA DRUM WORLD

Frances added: I have had people not recognise me. People are usually shocked at my results. A lot of people congratulate me on the hard work I have put in.

Everyone wants to know how I did it, I get that a lot. Just a lot of hard work and dedication.

I feel healthy, I have tons of energy that I never had before. Im confident, proud and extremely happy. Words cannot describe the feeling.

I have enough confidence to share my story with thousands of people in hopes they also can see how capable they are.

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Woman is unrecognisable after losing 9st naturally see her amazing transformation - Daily Star

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