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Opko: Contrarian Play On Positive Update – Seeking Alpha
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By S. Mitra, MBA (ISB)
Opko Healthcare (NASDAQ:OPK) stock offers a good buying opportunity at its current beaten down price due to a number of reasons. The company recently provided an encouraging update about its hGH-CTP Phase 3 setback that happened in December last year. Opko also initiated a Phase 3 study for hGH-CTP in the pediatric segment. This positive news is expected to get the stock out of its rut. Further, the stock is also expected to benefit from positive revenue growth for the company's newly launched Rayaldee product.
The company recently reported positive topline data analysis of the Phase 3 study of its investigational long-acting human growth hormone product (hGH-CTP) in adults with growth hormone deficiency ('GHD). This is the same drug whose December 2016 results led to the steep decline in Opko share prices. The results at that time failed to show a statistically significant difference over placebo. However, later the anomaly was attributed to the existence of outliers. The company now carried out a sensitivity analysis to quantify the impact of outliers on the results. Consequently, the results excluding outliers showed statistically significant differences to placebo. The data is encouraging as the company recently started a global Phase 3 trial for the drug in pediatric GHD patients. The pediatric trials are important as Opko stands to share profits upon the commercial launch of the drug for the pediatric market.
However, the bigger impact of the announcement is that it goes to prove that stock markets overreacted to the results of December 2016. The stock slumped nearly 20 percent in a single day. However, the stock's beaten down price now provides a good opportunity to create a position in the company as it still retains its strong fundamentals as is evident from its latest data announcement.
Opko partners with Pfizer (PFE) for hGH-CTP. The company received $295 million in upfront payments from Pfizer while the regulatory milestone entailed an additional $275 million. Opko is also entitled to royalties from adult hGH-CTP sales. The recent finding reassures us that the company may go ahead with its hGH-CTP testing in adults. This is a step forward for Opko to capture the highly lucrative growth hormone market, which is expected to touch $4.7 billion by 2018.
Opko has taken another innovative approach to capturing the growth hormone market as it is also testing more efficient methods of delivering the drug. While pharma companies are keen on developing newer growth hormone therapies, there is also increased focus on developing more efficient methods of delivering them. Its latest Phase 3 trial in pediatric market involves a multi-dose pre-filled pen for delivering the drug. The company also plans to use this pen for patients who continue in the open label extension phase of the adult Phase 3 and the pediatric Phase 2 GHD studies. This approach is expected to help the company in multiple ways. First off, better methods of drug delivery will help Opko in gaining a higher market share as these new methods are expected to be easier to use. Additionally, this approach may also make the therapy more attractive vis-a-vis upcoming biosimilars, which may negatively impact the growth hormone market by offering lower priced alternatives.
While the company has a well diversified drug portfolio and robust pipeline, it is also performing well financially. The company reported its consolidated revenue for the quarter ended March 31, 2017 at $296.1 million, up from $291 million it had reported for the corresponding quarter of the previous year. It ended the quarter with $131.1 million in cash, cash equivalents and marketable securities. Along with its steadily improving revenue stream, the cash balance offers a nice cushion for the company as it progresses with its trials and studies.
Another important catalyst coming up for Opko is the results related to its Rayaldee product. Rayaldee was commercially launched in the US by the end of last year. The company recently reported that Rayaldee is now accessible by 68 percent of all insured Americans. The company is counting on reaching 75 percent by the end of this year. Opko is expected to announce the revenue figures in its upcoming earnings announcement and the expected positive improvement in the outreach of the drug will likely provide yet another push to the lagging stock. The company plans to expand its sales force to promote the drug in the market.
Despite encouraging updates coming from the company, the stock's current performance is a cause of concern. At the same time, it is clear that the company has strong operational standing and thus good potential ahead. At the current price point, which is approximately 50 percent lower than its 52 weeks high of $12.15, the stock is cheaply priced, offering a good contrarian investment opportunity.
Disclosure: I/we have no positions in any stocks mentioned, but may initiate a long position in OPK over the next 72 hours.
I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Additional disclosure: Long PFE.
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Opko: Contrarian Play On Positive Update - Seeking Alpha
AllianceBernstein Global Hgh Incm Fd Inc – Receive News & Ratings Daily – Wolcott Daily
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July 31, 2017 - By Maria Brooks
KEMET Corporation is a manufacturer of passive electronic components. The company has market cap of $805.74 million. The Firm operates in two divisions: Solid Capacitors, and Film and Electrolytic. It has a 34.2 P/E ratio. The Solid Capacitors segment primarily produces tantalum, aluminum, polymer and ceramic capacitors.
AllianceBernstein Global Hgh Incm Fd Inc (AWF) formed multiple top with $14.18 target or 9.00% above todays $13.01 share price. AllianceBernstein Global Hgh Incm Fd Inc (AWF) has $1.12B valuation. About 28,624 shares traded. AllianceBernstein Global Hgh Incm Fd Inc (NYSE:AWF) has risen 7.26% since July 31, 2016 and is uptrending. It has underperformed by 9.44% the S&P500.
Since January 1, 0001, it had 0 insider buys, and 3 selling transactions for $2.62 million activity.
About 62,812 shares traded. KEMET Corporation (KEM) has risen 468.67% since July 31, 2016 and is uptrending. It has outperformed by 451.97% the S&P500.
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By1 Maria Brooks
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AllianceBernstein Global Hgh Incm Fd Inc - Receive News & Ratings Daily - Wolcott Daily
Viagra capsule – Viagra capsules price in india – Hayati Magazine (blog)
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Viagra capsule - Viagra capsules price in india - Hayati Magazine (blog)
HCG Diet | Rx HCG Diet Program | HCG Diet Info
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What is HCG?
HCG stands for Human Chorionic Gonadotropin and is a glycoprotein composed of 244 amino acids.
The use of HCG for weight loss was pioneered by British endocrinologist A.T.W. Simeons while studying pregnant woman on an extremely low calorie diet in India in the 1950s. He thought it was a medical oxymoron that pregnant women in a 3rd world country just devastated by war, would walk everywhere, work and eat just a handful of calories produce normal weight and normal height babies. His medical logic determined that these babies should be malnourished. This led him to discover that when a woman is pregnant, her body produces HCG. Also while in India, Dr. Simeons treated fat boys with pituitary problems with low doses of HCG. He observed both lost fat rather than lean muscle tissue.
How does the HCG Diet work?
HCG mobilizes the adipose tissue (abnormal fat). There are 3 types of fat.
A pregnant womans body will produce over 1 million IU (International Units) of HCG to mobilize the abnormal fat full of vitamins, minerals and nutrients to nourish the unborn fetus. Dr. Simeons wrote, In pregnancy it would be most undesirable if the fetus were offered ample food only when there is a high influx from the intestinal tract. Ideal nutritional conditions for the fetus can only be achieved when the mothers blood is continually saturated with food, regardless of whether she eats or not, as otherwise a period of starvation might hamper the steady growth of the embryo.
The use of HCG in conjunction with VLCD (Very Low Calorie Diet) produces weight loss but more specifically, fat loss. The HCG Diet will reshape your body. Your body needs reserve and structural fat but does not need abnormal fat to survive. By using HCG, your body releases the unlocked calories and nutrients stored in your abnormal fat. Therefore, HCG used with VLCD will produce not only weight loss but fat loss.
Can men do the HCG Diet?
Dr. Simeons also wrote, When a male patient hears that he is about to be put into a condition which in some respects resembles pregnancy, he is usually shocked and horrified. The physician must therefore carefully explain that this does not mean that he will be feminized and that HCG in no way interferes with his sex. He must be made to understand that in the interest of the propagation of the species nature provides for a perfect functioning of the regulatory headquarters in the diencephalon during pregnancy and that we are merely using this natural safeguard as a means of correcting the diencephalic disorder which is responsible for his overweight.
Why cant I just do the low calorie diet without HCG?
Well, if just reducing calories is the solution to overweight and obesity then why hasnt worked in the past? Lets face it; if youre investigating the HCG Diet then Id say youve tried other diets in the past without the desired results. There are 2 basic reasons one should avoid just reducing calories to lose weight.
These 2 basic reasons are why you have not been successful by reducing calories in the past. A combination of HCG and VLCD can mobilize and reduce your abnormal fat.
Call us to get started on losing up to 1 pound of FAT per day.
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HCG Diet | Rx HCG Diet Program | HCG Diet Info
The New HCG Diet | The Dr. Oz Show
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By now youve probably heard about it: the HCG Diet, an extreme diet that involves injections of HCG (human chorionic gonadotropin). HCG is the hormone women make when they are pregnant. Previously, the HCG Diet was defined by a 500-calorie diet paired with daily injections of HCG.
This diet is associated with dramatic weight loss, up to a pound a day. But the problem, up until now, was that no doctor could explain how it worked, and critics claimed the caloric restrictions are responsible for the weight loss and not the HCG hormone. Critics of the diet have also maintained that the weight lost cant be kept off. The HCG Diet has also had some odd rules. For example, it required the consumption of only one vegetable per meal, prohibited the use of oil, body lotions and hygiene products, and limited use of the HCG hormone to odd cycles of 23 and 46 days. The Diet also did not allow exercise. In addition, there had been no published guidelines on how to dose the HCG hormone; as a result, most providers of this diet are generally using random dosing of the prescription hormone. This was called the Simeons Protocol, and, in my opinion, it was wrong.
After years of research and treating thousands of patients, I am setting the record straight. The Simeons Protocol should no longer be in practice by any physician. My protocol is supported by numerous studies and clinical trials, the latest of which was presented to weight loss physicians at the October 2012 meeting of the American Society of Bariatric Physicians, and can be read at DrEmmasDiet.com. My dosing method is customized, with much higher doses than previously published, and Ive created specific guidelines for patients based on age and gender. I offer diets ranging from 500-1500 calories, and the diet should be chosen based on the patient and their history. I also encourage the proper types of exercise.
So, the most pressing question is: Do HCG injections work for weight loss? My answer is yes, absolutely. The trickier question is: How does HCG work for weight loss?
Here is my explanation, based on my research. Remember, HCG does not make you lose weight the diet makes you lose weight! However, the HCG injections change how you lose weight!
HCG injections keep you from losing muscle while you diet. By elevating hormone levels in the body, including testosterone, the HCG hormone creates an anabolic state (muscle-building) which counteracts the catabolic state (muscle-breakdown). There are hormone receptors on muscle fibers that respond to the increased hormone levels in patients taking the HCG hormone.
Why does that matter? During a fast, dramatic loss of pounds with crash dieting, there is a high amount of muscle that is lost. Because muscle is heavy, this loss looks good on the scale because the pounds are dropping quickly. When you lose muscle, its bad for your body, shape, and metabolism. The metabolism slows so much that dieter regain weight quickly, often regaining all the weight that was lost and then some. Additionally, it takes quite a bit of work to build back the muscle that has been lost.
My protocol, however, protects muscle from being lost. In fact, there is more of a pure fat loss, which causes a shrinking in inches and size of clothing. The great result is that one can become leaner, in a smaller clothing size, but with more muscle. This muscle allows for a stronger metabolism and helps people maintain their weight loss long after their diet is completed.
Read more about Dr. Emma's research study.
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The New HCG Diet | The Dr. Oz Show
Clomid doses for infertility – Infertility in women- blocked fallopian tube – Hayati Magazine (blog)
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Clomid doses for infertility - Infertility in women- blocked fallopian tube - Hayati Magazine (blog)
8 Best And Proven Face Exercises To Lose Weight In Your Face
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When we talk about appearance, the face is certainly the most astonishing body part that people notice first. It is not enough just to pamper your skin externally; a chiseledjawlineand high cheekbones are the trends in the meantime that outline the face and give it a sharp edge.
Facial exercises are equally important as physical exercises which helps to weight reduction and toning the shape of your body.
Be fair! Have you ever questioned yourself? How to get slimmer facelike aProfessional model!
HmmmProbably, YES!
So the very next thing comes into your mind isHow they have made it? Is there any magic pills or dark secrets behind it?
NOPE! they achieved it by doing proper facial exercises following a healthy diet plan. Moreover, We are giving you simple tips to acquire the exact face cut by performing these easy exercises.
(Warning: Do not attempt in public spaces if youd still like to have friends.)
The chin lift exercise is a great way to get rid of a double chin. It assists in working and stretching most of the facial muscles which includes jaw, throat and neck. But make sure not to use any other facial muscle other than the lips while doing this exercise. You can perform this exercise either in the sitting or standing position. Begin by tilting your head towards the ceiling, keeping your eyes fixed towards it. Now, make your lips tight, as if trying to kiss the ceiling, hold it till a count of 10 seconds and relax.
RELATED: How To Prevent And Get Rid Of Acne Scars Quickly
The lips pull is one of the most effective facial yoga exercises, which when practiced regularly can help in lifting up the face muscles and take away years from your face, offering you look more youthful with high cheekbones along with a prominent jaw line. Begin in a standing or sitting position with your head in the normal position. Now, lift your lower lip up as much as possible by pushing the lower jaw out. You are sure to feel the stretch and strain build in the chin muscles and jaw line. Stick with this posture for 10 to 15 seconds and relax.
Get attractive, high cheekbones and a sexier jaw line jaw release exercise, which is certainly one of the most effective facial exercises for double chin reduction. It helps in stretching and dealing the muscles around your lips, jaws and cheeks. Begin with sitting or standing in a straight posture and moving your jaw just like you are chewing while keeping your lips closed. Breathe in deeply and breathe out while humming. Next, open your mouth wide with your tongue pressed within your bottom teeth. Hold this posture for 5 seconds, now breath in and out again. This makes one repetition.
The fish face exercise, also termed as smiling fish face is a simple and one of the best facial exercises for cheeks that one could do anywhere you like while watching T.V or listening to your favorite song. This exercise helps in toning and spreading cheek muscles and lose the face fat fast. Just suck in your cheeks and lips as we use to do now try smiling, hold the posture for 5 seconds, you will feel the burn in your cheeks and jaws.
The blowing air exercise helps in solving the problem by working almost all the facial and neck muscles and it is one of the effective face exercises to reduce double chin and getting rid of chubby cheeks. It impacts on the cheeks, jaws and neck muscles and tones them to provide a natural face lift to give a leaner appearance.Sit on a chair with your spine straight, tilt your head back to any extent possible to make sure that you face the ceiling, pull your lips and blow out air from your mouth. Continue for seconds and relax.
Here is another quite simple technique. You just need to close the eyes firmly with the help of the muscles of your cheeks. You got to make it sure that you are having a feel of the contraction of your muscles on the face. Just stay in the position for 10 seconds and relax your face muscles after ten seconds. The technique should be repeated 5 times a day at least.
Another important technique of the face muscles exercise is to stretch you face muscles with the help of your hands. You can do it by lowering your chin in such a way that it starts touching the chest. Then pull the skin in such a way that your skin moves below the cheekbones. Once you are in perfect position, you have to pronounce Ah. Remain in static position for a while and repeat the procedure three times a day.
Smiling is the best opportunity you can have to trim down your cheek fat. Its a best and most easy workout you can do for your cheeks. Lets see how technically its helpful for you to lessen the cheek fat.A smile stretches the muscles of your cheeks. This muscle stretching may lose the fats of the cheeks and really help in toresolve this problem.
These are all simple exercises for the face that you can do anytime and anywhere to lose cheek fat. These exercises on losingcheek fat may sound simple but the effect they can have on your face is huge.
If done regularly, these exercises can slim down your face and, at the same time, tone up facial muscles. They can also improve your facial skins elasticity and firmness, making your face look more youthful and thinner.
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8 Best And Proven Face Exercises To Lose Weight In Your Face
Exercise for health: you know you have to – Sonoma West
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Sonoma County is a lousy place to live for people looking for excuses to not eat well or stay physically active. Thats because fresh, tasty and wholesome foods are grown and produced here year-round and the areas natural beauty, open spaces, trails and walkable neighborhoods are daily invitations to get in motion.
And, for those trying to make more stubborn excuses to sit on their butts, the area is also full of organized exercise programs, health clubs and wellness services.
According to the American Heart Association (AHA), some 80 percent of the general population does not make exercise a daily habit and 14 percent admit they pretty much detest exercising. At the same time, these same people know that a daily walk or semi-regular exercise program could save their life from a heart attack, stroke or chronic lifestyle disease like diabetes, hypertension or obesity.
Do something,is what Jane Trebilcock, a personal trainer at Parkpoint Health Club advises. Theres not just one answer except you should try to find an exercise routine you will enjoy and wont feel like its a chore.
The AHA says people can reduce heart failure and gain cardio health with just 150 minutes of moderate exercising a week. That could be a 30-minute walk around the neighborhood just five days a week. A more vigorous workout like bicycling, swimming or running for 25 minutes, three days a week is also recommended. Just 40 minutes of regular exercise will lower a persons blood pressure and cholesterol levels by 3-4 times, the AHA reports.
One key to success is to find a friend to join your workouts, said Trebilcock, or get someone to help you be accountable. In some cases that friend could be a dog that needs daily walking.
Parkpoint is just one of many local health clubs, gyms, yoga studios or organized classes available to individuals at a wide range of fees, from free to higher-cost personal trainers.
Some people will be extra motivated by joining a group or class, but some will prefer more individual workouts, said Trebilcock.
Setting aside specific times and days helps people keep healthy habits. Many wellness professionals stress establishing a routine based on set time periods, heart rate targets, measured distances or weight loss goals.
A rather new exercise option can be found at Sebastopols Boundless Studio where personal-sized mini-trampolines are used to gain twice the cardio and fat-burn results in half the time with no jarring or joint strain that are part of running or regular floor exercises.
Theres no one who shouldnt be rebounding,says studio owner Tanya Scott. Its super effective. You get three times the benefit and it feels less exhaustive.
Scott offers both individual and class sessions and she says her programs are great compliments to a persons yoga or Pilates routines. An added benefit of the Boundless workouts is they improve balance and coordination for people seeking to avoid falls and joint injuries.
Living well cant happen by only joining a health club or exercise class. Healthy diets and eating habits must be part of any persons plan to fight heart disease or weight issues, the AHAoutlines recommend.
Rest and adequate amounts of sleep are essential to good health and maintaining or increasing self-esteem is vital, too, the same guidelines include. (www.heart.org.)
You want to do it rain or shine and if you miss a day or a class dont give up, said Trebilcock. If you can stick to a routine or schedule for six months (then) you should feel like you are really committed.
Physical exercise plans, Trebilcock stresses, should include three basic activities which are cardiovascular (heart rate) aerobics, strengthening (weights or machine) and flexibility (stretching, yoga, Pilates.)
At Parkpoint, Trebilcock and the other physical trainers work with all profiles of individuals from various age groups to triathletes to heart attack and cancer survivors to hurried professionals to more relaxed retirees.
Sonoma County is full of aging Baby Boomers (age 53-71) and places like the fitness room at Parkpoint are full of this graying population that is expected to live longer than all past generations.
Staying active for this older generation has taken on added importance that is being measured and enjoyed by an improved quality of life.
In other words, if you know you are going to live longer, you might as well live well.
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Exercise for health: you know you have to - Sonoma West
Exercise Training Improves Physical Function in Brain Tumour Survivors – Medical News Bulletin
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The good news is survival rates for children diagnosed with malignant brain tumours (BTs) are greater than 70%. The bad news is that these kids have decreased physical function, impaired fitness, and poor functional mobility. Even more, they are discouraged from physical activities since many communities, or school-based physical programs are not designed for them, and the parents may restrict physical activities to protect them from any perceivable harms. However, physical activity may improve their quality of life significantly, as suggested by accumulating evidence that exercise improves cancer outcomes in adults. Unfortunately, little is known about how a regular exercise regimen can improve physical functions on pediatric BT survivors.
A new study published in the European Journal of Cancer examined whether exercise training improves physical functions in pediatric BT survivors. 32 children (6-17 years of age) treated with cranial radiation for brain tumours were divided into an exercise training group or no training control group. For 12 consecutive weeks, the children had 3 training sessions per week of 90 minutes of different cardiorespiratory physical activities. The majority of the participants adhered to their exercise program. They found that the 12-week training resulted in improvement of bilateral coordination and this lasted even 12 weeks after the end of the training.
This study was the first investigation examining the efficacy of exercise in long-term survivors of pediatric BTs, and showed that exercise training improves their physical function and fitness. So, developing exercise programs that include these children and allowing them to participate in an appropriate amount of exercise will do more good than harm.
Written By:Boram Ham, PhD
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Exercise Training Improves Physical Function in Brain Tumour Survivors - Medical News Bulletin
New program pairs shelter dogs with workout buddies at District … – KEYT
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New program pairs shelter dogs with...
SANTA MARIA, Calif. - Santa Barbara County District Attorneys' Office employees will have the opportunity to exercise with a friend thanks to a new partnership with the Santa Maria Valley Humane Society.
The 'DA Dogs' program pairs well-mannered, adoptable dogs with employees at the DA's office who want to walk or run with the dogs during their lunch break.
Well-mannered, adoptable dogs are being paired with SB County District Attorney's Office employees. (Amanda Valdes/KCOY)
The attorneys and staffers at the DA's officein Santa Maria will run, walk and play with the dogs before they are returned to the shelter where they are available for adoption.
The first-of-its-kind program encourages people and pets to exercise together while promoting pet adoption.
The district attorney's office has many animal lovers and Santa Barbara County District Attorney Joyce Dudley said she wanted to do something to encourage the adoption of homeless pets.
Well-mannered, adoptable dogs are being paired with SB County District Attorney's Office employees. (Amanda Valdes/KCOY)
Each running partner pup wears a vest with the words "Adopt Me" printed prominently for all to see.
Shelter officials say the new experiences help the dogs become more comfortable outside of the shelter which helps them better acclimate with their new homes once adopted.
The high energy employees at the DA's office offer a service that allows dogs to get exercise that they might not always get due to limited staff at the shelter.
The Santa Maria Valley Humane Society said that additional programs are in the works with the DA's office and the Santa Barbara County Sheriff's Office.
All of the animals who participate in the 'DA Dogs' program are available for adoption at the Santa Maria Valley Humane Society at 1687 West Stowell Road. Adoptable pets can be viewed online.
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New program pairs shelter dogs with workout buddies at District ... - KEYT