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Lesa Walton suffered for years with rheumatoid arthritis. It was awful, said Ms. Walton, 57, who lives in Wenatchee, Wash. I kept getting sicker and sicker.

She also had high blood pressure, and she was obese. Doctors told her to diet and exercise, which she did, to no avail.

Then she found a doctor who prescribed Wegovy, one of the new obesity drugs. Not only did she lose more than 50 pounds, she said; her arthritis cleared up, and she no longer needed pills to lower her blood pressure.

Her new doctor, Dr. Stefie Deeds, an internist and obesity medicine specialist in private practice in Seattle, said that Ms. Walton exemplifies a growing movement in obesity medicine.

Proponents call it obesity first. The idea is to treat obesity with medications approved for that use. As obesity comes under control, they note, the patients other chronic diseases tend to improve or go away.

We are treating the medical condition of obesity and its related complications at the same time, Dr. Deeds said.

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Doctors Test the Limits of What Obesity Drugs Can Fix - The New York Times

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Ashley Benson is opening up about her post-baby body.

Back in February 2024, the 34-year-old Pretty Little Liars actress gave birth to her and husband Brandon Davis first child, a baby girl.

Months after the babys birth, Ashley took to Instagram on Monday (June 17) to show off her post-baby body and many followers took to the comments to speculate that shes taking Ozempic to lose the baby weight.

How was she JUST pregnant?!? one person wrote, while a follower replied by posting an image of Ozempic, the type 2 diabetes medication many stars are taking to lose weight.

Following all of the speculation, Ashley took to her Instagram Story to reveal if shes really taking Ozempic.

Keep reading to find out moreComments like this are so funny to me, Ashley wrote along with a screenshot about all of the Ozempic speculation.

I know a lot of people take Ozempic and thats totally fine. To each their own, Ashley continued. But dont discredit people who also work very hard to get their body back like Ive done with mine.

She added, Getting back to work forced me to focus on my health and working out and I wanted to feel confident and good about myself.

Ashley concluded her message by thanking health and wellness expert Melissa Wood Tepperberg for helping her get in shape.

And again, couldnt do this without my @melissawoodtepperberg app, Ashley wrote.

An Oscar-nominated actor also recently responded to speculation that theyre losing weight by using Ozempic.

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Ashley Benson Reveals If She's Using Ozempic to Lose Weight After Giving Birth to First Child - Just Jared

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If you're someone who depends on coffee to wake up and increase energy levels, there's an innovative dietary supplement available that not only promotes healthy weight loss but also contributes to overall wellness.

Here's the inside information: this weight loss product aids in maintaining an ideal body weight and prevents excessive fat buildup in your cells. Introducing FitSpresso!

This natural supplement for weight loss tackles all your concerns about managing weight, enhancing your lifestyle. FitSpresso goes beyond the typical weight loss solutions that only focus on biological factors leading to unexplained weight gain. It offers a comprehensive approach, transforming the weight loss journey and making a lasting impact on users! Learn more on the official website

We're genuinely impressed by the efficacy and ingredients of this weight control formula, enabling individuals to lose weight without committing to an exercise regimen or strictly adhering to a balanced diet. The natural elements in FitSpresso demonstrate a dedication to health and wellness. Furthermore, unlike many weight loss products, FitSpresso aligns perfectly with the vegan lifestyle, which excites us vegan-friendly enthusiasts immensely!

In FitSpresso testimonials, millions of users echo our sentiments, confirming that nothing rivals the simplicity of this efficient weight control formula, effortlessly incorporating the morning coffee ritual into a natural weight loss journey.

Therefore, let's delve further into our findings and examine how FitSpresso can serve as a valuable asset in your weight management efforts. To begin, let's briefly explore the key features of the FitSpresso weight control formula.

Try Coffee Loophole now and experience the difference!

Is FitSpresso Coffee Efficient for Weight Loss?

Examining the FitSpresso dietary supplement closely evokes a favorable impression. The packaging displays careful attention to detail, with a label that omits any reference to detrimental components. Furthermore, an official website provides pertinent details, bolstering its reliability. Nonetheless, considering its classification as a health supplement, it's prudent to exercise additional care.

The supplement garners thousands of customer appraisals online, validating the excitement surrounding it. However, to truly understand its authenticity, it's essential to delve into specifics like the formulation, constituents, mode of operation, and the scientific basis underpinning it.

In the forthcoming segments of this FitSpresso coffee assessment, you'll encounter thorough details encompassing customer testimonials, pricing, and formula accessibility prior to arriving at a conclusion. Continue reading to unveil all the essential insights about the FitSpresso weight control formulation.

Who is Behind FitSpresso Coffee Loophole?

In 2019, a team of researchers from the UK serendipitously uncovered a straightforward method for losing weight. Their discovery pointed to a connection between the sluggishness of your metabolism and disruptions in the Circadian Rhythm of your fat cells.

Drawing inspiration from these revelations, Dr. Hoffman formulated a blend aimed at preserving the openness of your circadian rhythm window, thereby encouraging fat burning. To optimize this process, he carefully amalgamated various natural ingredients in precise ratios to complement coffee and prolong the duration of this fat-burning phase.

With collaborative contributions from fellow researchers and experts, Dr. Hoffman refined this powerful blend through numerous trials. Its manufacturing occurs in an FDA-approved and GMP-certified facility, ensuring its effectiveness and potency.

Coffee Loophole Explained

FitSpresso emerges as an outstanding solution for reducing weight, delivering a natural enhancement to your metabolism and providing sufficient energy to accelerate your journey towards weight loss. Brimming with ingredients such as Capsicum annum, chromium picolinate, Panax ginseng, L-carnitine, and others, FitSpresso is conveniently available in capsule form.

This weight loss coffee, encapsulated for convenience, surpasses the ordinary cup of joe; it's meticulously crafted with natural constituents validated to boost metabolism and intensify fat-burning capabilities. Intended for daily consumption, preferably in the morning with a cup of warm water, FitSpresso Coffee represents the culmination of years of research and clinical investigations conducted by a consortium of scientists, physicians, and wellness experts. They expertly combined the potency of coffee with other impactful ingredients to formulate a distinctive blend that promotes safe and efficient weight loss.

As per the manufacturer, the formulation of this supplement results from a collaborative endeavor involving experts in nutrition, medicine, biochemistry, and pharmacology. The developers of FitSpresso assert that their dietary blend fills a void left by other popular supplements in the weight loss domain. Making bold claims of enabling weight loss of up to 35 pounds within just 20 days, the team responsible for the formulation highlights its unique approach.

This herbal weight loss blend is conveniently encapsulated in easily dissolvable capsules and is meant to be consumed by blending with coffee. According to the creators, FitSpresso is meticulously designed to augment the metabolism-boosting properties of coffee. The seamless fusion of this blend with coffee renders it effortlessly integrable into our daily dietary regimen, as per the developers.

Get started today and see the difference FitSpresso can make

How Does FitSpresso Coffee Work to Promote Weight Loss?

FitSpresso challenges the conventional notion of the fat paradox, where deliberately reducing calorie intake to burn calories can result in a decline in metabolic rate, as the body conserves energy in response to a calorie deficit. The FitSpresso supplement is formulated to boost metabolism and facilitate the body's shift into fat-burning mode, regardless of your dietary preferences. Crafted with natural ingredients, the supplement not only suppresses appetite but also enhances your Basal Metabolic Rate (BMR), encouraging the utilization of stored fat.

By influencing the circadian rhythm of your fat cells, FitSpresso prolongs the period for fat burning and enhances your metabolic rate, enabling increased calorie burning during this timeframe.

The fast-acting formulation of FitSpresso Coffee springs into action within just 7 seconds. Following the recommendation to ingest one capsule each morning alongside your coffee, this regimen alters the circadian rhythm of your fat cells. Consequently, they become prepared to burn fat for extended durations. In simpler terms, if your cells typically engage in fat burning for 30 minutes in the morning, this unique coffee-infused approach ensures that fat oxidation persists throughout the entire day.

Furthermore, FitSpresso doesn't just improve your metabolic functions, accessing stored fat, but it also speeds up the fat-burning process. This not only increases your energy levels but also acts as a preventive measure against rapid weight gain. Essentially, the blend of natural elements in this fat-burning formulation promotes healthy weight loss by stimulating thermogenesis and fat oxidation. Consequently, your cells utilize fatty acids to reduce body weight, promoting your overall health.

The combination of ingredients in FitSpresso works synergistically with coffee, amplifying its metabolism-boosting and fat-burning properties. According to the developers, this weight loss supplement is crafted to tackle a fundamental factor contributing to excess body fat.

The concept behind FitSpresso centers on the circadian rhythm of adipocytes, which are responsible for storing body fat, similar to our sleep patterns. A study carried out by UK scientists in 2019 supports this concept, demonstrating that fat cells experience cycles of storing and burning fat. The researchers identified clock genes in adipocytes that govern the natural rhythm of these cells, impacting the duration of periods dedicated to fat storage and fat burning.

FitSpresso is strategically effective in the morning, taking advantage of the body's prime fat-burning conditions during that timeframe. It contains nutrients that stimulate metabolic activity and aid in the breakdown of fat during these morning hours.

Moreover, other components in FitSpresso provide nutrients that significantly enhance the weight-loss properties of coffee, multiplying its effectiveness manifold.

List of Components Included in FitSpresso Coffee

The effectiveness of a supplement is unquestionably influenced by the ingredients it contains. Therefore, to offer you a thorough comprehension of FitSpresso, we've explored the intricate mechanisms of its components, elucidating the scientific rationale behind each element:

Dont wait, read the reviews today!

What are the Health Benefits of FitSpresso?

Having delved into how FitSpresso aids in shedding pounds, you might be interested in its other health perks. While experiences may differ, here's a compilation of commonly noted health benefits shared by FitSpresso consumers, aside from the apparent weight reduction:

Who are Prescribed to use FitSpresso?

Fitspresso Coffee is ideal for individuals striving to lose weight and improve overall health and wellness. It is advantageous for the following categories:

Instructions to Use FitSpresso Coffee Loophole!

Adhere strictly to the capsule intake instructions provided on the label. As per the official website, it is recommended to consume one capsule daily with a glass of water first thing in the morning.

For best absorption and to fully leverage the health benefits of FitSpresso, it is advised to take the capsule on an empty stomach.

Is There Any Adverse Effect of FitSpresso?

FitSpresso reviews generally have not indicated any negative side effects, likely due to the supplement's compliance with rigorous manufacturing standards and comprehensive third-party testing, ensuring both quality and safety.

Despite the favorable reviews, it's crucial to understand that the information on the official website may not be exhaustive. The supplement might pose health risks for certain individuals and could interact with specific medications. It is recommended to avoid using FitSpresso if you:

Additionally, it's important to be aware that the supplement contains Silicon Dioxide, which has been linked to an increased risk of cancer.

Pricing Details of FitSpresso Coffee

The FitSpresso weight loss supplement offers affordable options to suit various budgets. The pricing details for FitSpresso are as follows:

Read what others are saying and decide for yourself >>>

Where to Order FitSpresso?

The official website is the only destination on internet from where one can order the monthly supply of FitSpresso.

This is a sponsored article. The article should not be considered as advice.

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Have You Ever Tried FitSpresso (The Coffee Loophole Recipe)? Here are The Real Experts Reviews! - The Jerusalem Post

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In abstracts presented at ASCO 2024, the annual meeting for the American Society of Clinical Oncologists, researchers discovered that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were significantly beneficial in treating obesity among women with breast cancer. They also explored GLP-1RA use for anthracycline or HER-2 inhibitor-treated patients with breast cancer and diabetes, finding a reduction in major adverse cardiovascular events (MACE).1,2

Weight gain and obesity are significant problems for women receiving adjuvant therapy for breast cancer and obesity is associated with adverse breast cancer outcomes. In addition, obesity is associated with negative impact on overall physical and mental health. The GLP-1 agonists, semaglutide and tirzepatide, are effective in achieving weight loss and have been associated with decreased incidence of diabetes, stroke, and overall mortality in the non-diabetic as well as diabetic populations, wrote Fischbach et al.1

GLP-1s, such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) have taken over as the highest-selling prescription drugs in the US. | image credit: Ole / stock.adobe.com

GLP-1s, such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) have taken over as the highest-selling prescription drugs in the US. In 2023, for example, semaglutide overtook the cancer medication adalimumab as the highest-selling drug in the country, and experts predict that trend to continue through 2024.3

With ongoing trials to explore GLP-1 treatment beyond diabetes and weight loss, researchers at ASCO 2024 examined the drugs uses for patients with breast cancer. Analyzing GLP-1 efficacy in various cohorts, researchers presented their findings in the attempt of rapidly expanding GLP-1 research and data.

Researchers aimed to address GLP-1 use for weight loss and cardiovascular (CV) outcomes in women with breast cancer. There are limited data on the efficacy and safety of GLP-1 agonists in women with breast cancer, they wrote.1

READ MORE: GLP-1s Improve Taste Sensitivity, Reduce Body Weight in Patients with Obesity

Researchers examined over 92,000 medical visits for 7149 patients. Using data from the Yale Cancer Center and Yale New Haven Health Network from 2017 to 2022, they performed a retrospective analysis of semaglutide and tirzepatides association with weight loss in patients with breast cancer at stage I, II, or III.1

They gathered 5430 evaluable patients (mean age, 58 years) with non-metastatic disease and found that just 1.3% of the population was prescribed either semaglutide or tirzepatide.

The pretreatment mean weight was 95.8 kg (211.2 lbs) and mean body mass index (BMI) was 35.9 kg/m2. For patients treated with either GLP-1RA, mean weight loss was 3.03 kg (6.68 lbs), which accounted for a decrease of 1.1 for mean BMI. The mean maximal weight loss for semaglutide- or tirzepatide-treated patients was 8.89 kg (19.60 lbs), which accounted for a maximal reduction in BMI of 3.2.1

In this retrospective analysis, [GLP-1RAs] are associated with clinically meaningful weight loss in overweight and obese women with early breast cancer. Recurrence risk did not appear to be preliminarily impacted by treatment. Additional research is needed on long term safety as well as weight loss maintenance with these drugs in breast cancer survivors, concluded authors of the abstract.1

Analyzing a much more specific study population, a second abstract addressed GLP-1 use among patients with breast cancer and diabetes also receiving anthracycline or HER-2 inhibitors.

Anthracyclines or HER-2 inhibitors are associated with the potential for [MACE] among patients with breast cancer. Diabetes further increases the risk of MACE, wrote the authors.2

Researchers included adult patients with breast cancer and type 2 diabetes that were previously prescribed anthracyclines or HER-2 inhibitors. Then, patients within this population were given a GLP-1 prescription and matched with a cohort receiving no GLP-1 and instead a second-line diabetes medication.

Among the study population, 724 patients receiving GLP-1s were matched with a non-GLP-1 group (median age, 60 years for both groups). The prevalence of hypertension (81%), metastatic disease (61%), and radiation therapy (42%) was similar between cohorts, as was the use of anthracyclines and HER-2 inhibitors, they continued.2

Compared with the non-GLP-1 group, those receiving GLP-1 treatment reported a reduced risk of MACE, heart failure hospitalization, and all-cause mortality.

[GLP-1s] were associated with a reduction in major adverse cardiovascular events, incident heart failure and heart failure hospitalization, and all-cause mortality among anthracycline or HER-2 inhibitor-treated patients with breast cancer and [diabetes], concluded the authors.2

Click here for more of our coverage from ASCO 2024.

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GLP-1s Lead to Weight Loss, Improved CVD Outcomes in Breast Cancer - Drug Topics

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When intermittent fasting went mainstream around 2018, many thought it was just another diet fad that would come and go. However, its clear that intermittent fasting eating patterns are here to stay; encompassing an eating pattern that humans have practiced for centuries. Dating back to the primal era, our ancestors often ate only when food was available, keeping meals within a specific window instead of our modern-day approach to eating multiple times a day.

Intermittent fasting helps condense your daily calories into a period, often between 8 to 10 hours, helping to keep your insulin levels at bay. This eating pattern challenges the breakfast is the most important meal of the day myth one that has been told for centuries by our parents and grandparents. But the process can take time to master, especially if youre used to eating 3 to 6 times a day. If youre not losing weight with intermittent fasting, consider tweaking these 5 things to achieve your desired results.

One of the most important principles to understand about intermittent fasting is that there is no right or wrong approach to this eating pattern. Each persons hormones vary and will respond differently to fasting. With this in mind, youll want to make small adjustments, slowly tweaking your fasting routine until you find what works for you. Not only can you change what you eat and how much you eat within your eating window, but you can also adjust eating window times to work for your schedule, such as the classic 16/8 or 20/4 intermittent fasting routines.

Perhaps the most obvious factor to consider if youre not losing weight with intermittent fasting is your fasting pattern. When you first begin intermittent fasting, chances are you gradually had to adjust to not eating breakfast, slowly pushing your fasting pattern from 12 hours to 13, 14, etc. Although a 12-hour fast may have produced weight loss initially, this fasting period may not be long enough as your body adapts. If intermittent fasting is not working as youd like, consider fasting for longer periods a few days per week. For example, an OMAD routine is a great option to jumpstart your metabolism once or twice a week.

Another factor to consider is the timing of your meals, which is not the same as your fasting pattern. A 16-hour fast followed by an 8-hour eating window could involve two meals (for example: lunch at noon, dinner completed by 8 pm, and fasting from 8 pm to 12 pm again the following day. Yet, another person could approach the same 16/8 pattern but consume their meals at 2 pm and 10 pm instead. If you arent losing weight with intermittent fasting, changing your meal timing could help break a plateau. Consuming food too close to your bedtime could stall your loss, so shifting your meal timing earlier could be beneficial.

Intermittent fasting is a powerful tool to keep in your belt, but it is not a miracle pill. Weight loss still occurs from a sustained calorie deficit over a prolonged period. If youre struggling to lose weight with intermittent fasting, consider tracking your macros to see how many calories youre consuming. Consuming too many (or too few) calories could leave your body struggling to burn fat. When calculating your calorie goal, be sure to account for any calories consumed from exercise.

During your fasting window, it is important not to consume any calories to keep your body in fat-burning mode. Are you consuming any hidden calories during your fast or consuming anything that could cause a spike in blood sugar? Some examples of common culprits include artificial sweeteners added to tea or coffee, creamer, or gum/sugar-free candies. Even no-calorie sweeteners can produce a glycemic response, interfering with the effectiveness of your fast.

When combined with a healthy, well-rounded diet, exercise is a powerful tool that can help enhance the results of your intermittent fasting routine. Regular cardiovascular exercise (such as walking) along with a weight-lifting routine can help you burn fat and gain muscle to support your weight loss. A recent study found that participants who exercised during a fasting window (on an empty stomach) burned more fat than compared to those who exercised two hours after eating.

Although exercising on a fast seems to challenge the norm, it might be what you need to kickstart some weight loss during a plateau. Our bodies adapt surprisingly well to new routines, so be patient with yourself as your body learns to utilize fat for fuel during your workouts.

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Not losing weight on intermittent fasting? These 5 reasons might be why - The Manual

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She helped him lose weight now she wants him to stop. Scott Disicks gaunt appearance has more than fans worried about his health. An insider tells Life & Style his exs sis Khlo Kardashian is terrified about the dad of threes health.

On The Kardashians, Khlo gave Scott a pep talk after he gained weight while recovering from a horrific 2022 car crash. (Not the most nutritionally informed, the 41-year-old admitted to eating a box of Hawaiian rolls a night and thinking sugary ginger ale was a healthy choice!)

But he did more than change his diet. Eagle-eyed viewers spotted the weight-loss drug Mounjaro in his fridge. Saying he looked amazing on a recent episode, Khlo, 39, cautioned, But youre gonna stop losing weight, right?

Which Celebrity Had the Most Inspiring Weight Loss Transformation?

She knows what shes talking about. The mom of two has faced her own weight struggles and been criticized for being scary skinny in the past. Its something Khlo empathizes with, says an insider. And Scotts reluctantly agreeing enough is enough. Privately, he admits that his extreme weight loss has made him a laughingstock.

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Khloe Kardashian Fears for Scott Disick Amid His 'Extreme Weight Loss': She 'Empathizes' With Him - Yahoo Entertainment

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Pharmaceutical companies expect that demand for anti-obesity drugs will increase as price comes down.Credit: CFOTO/Future Publishing via Getty

Blockbuster weight-loss drugs such as Wegovy could soon become a lot cheaper and reach more people thanks to Chinese and Indian pharmaceutical companies. A long queue of companies is developing copies of the complex biological drugs, and some are racing to create modified or improved versions to compete in the global market.

There is huge potential for companies from India, China, that can help create access to these drugs, says Abhijit Zutshi, chief commercial officer of the pharmaceutical giant Biocon, headquartered in Bengaluru, India, who oversees its generics business and is based in Woodbridge, New Jersey.

These companies will bring drugs to patients who need it, at a cost that can be afforded, says Guy Rutter, a cell biologist at the University of Montreal, Canada.

Globally, one billion people have obesity or are overweight and hundreds of millions of them live in India and China. Lei Qian, vice-president of clinical development at Innovent Biologics in Shanghai, China, says that demand for anti-obesity drugs is very strong in the country.

In the past few years, a new class of weight-loss drugs has taken the world by storm. They work by mimicking a naturally occurring hormone called glucagon-like peptide 1 (GLP-1). GLP-1 not only regulates blood sugar levels, but also binds to receptors in the brain that control appetite and receptors in the gut that slow digestion and contribute to a feeling of being full.

In 2014, the US Food and Drug Administration (FDA) approved the first class of GLP-1 drugs for weight loss. Liraglutide, marketed as Saxenda by Novo Nordisk, based in Bagsvrd, Denmark, is a daily injection that can trigger an average body-weight loss of 8% after a year.

Obesity drugs have another superpower: taming inflammation

The next generation of these drugs required fewer injections and led to greater weight loss. In 2021, the FDA approved semaglutide, sold as Wegovy by Novo Nordisk, as a weight-loss treatment, and in 2023 it approved tirzepatide, marketed as Zepbound by Eli Lilly, based in Indianapolis, Indiana. Tirzepatide mimics GLP-1 as well as another hormone that stimulates insulin secretion, known as glucose-dependent insulinotropic polypeptide (GIP).

Semaglutide and tirzepatide are weekly injections that can induce an average body-weight reduction of between 12% and 18%. In addition to their slimming effects, these drugs are marketed under different brand names, such as Ozempic, as treatments for type 2 diabetes. Clinical trials have also shown that they can reduce the risk of kidney failure, tame inflammation and protect against serious heart problems.

But the drugs are expensive a months worth of semaglutide or tirzepatide injections can cost upwards of US$1,000. One way that Indian and Chinese pharmaceutical companies plan to slash that price is by developing biosimilars, cheaper versions of expensive brand-name drugs. Unlike generics, which are exact copies of chemically synthesized branded drugs, biosimilars very closely resemble their reference product and are derived from modified living organisms, such as yeast.

Companies are preparing to release biosimilar versions of GLP-1 drugs when patent protections lift in different markets. In China, the patent for liraglutide has already expired, and the one for semaglutide will expire in 2026 in India and China.

Companies are also innovating in how they synthesize the drugs, fill the vials and manufacture the injection devices, says Zutshi, whose company is focusing on developing biosimilars for the global market.

How much the cost will drop is yet to be seen, says Zutshi. It could be cut in half, or be one-tenth the current price, he says. If drugs are cheaper, more people will use them, thus expanding demand, he adds. This, in turn, could have a ripple effect in which companies reduce the price of existing weight-loss drugs in anticipation of the competition coming.

No weight-loss biosimilars have yet been approved in India, but Glenmark Pharmaceuticals in Mumbai, India, launched Lirafit, a liraglutide biosimilar, in January for treating type 2 diabetes. Glenmark said in a press release that, at some 100 rupees a day (US$1.20), Lirafit costs 70% less than existing therapies. Biocon has also developed a liraglutide biosimilar, which was approved by the UK drug regulator for type 2 diabetes in March but their product is not on the market yet. Biocon says it is developing semaglutide biosimilars to launch in select countries as soon as 2026.

Chinas drug administration has approved two GLP-1 drugs produced by Chinese companies for weight loss. The first is a liraglutide biosimilar marketed as Liluping, made by Huadong Medicine in Hangzhou. The second is beinaglutide, marketed as Feisumei by Benemae Pharmaceutical Corporation in Shanghai.

Several companies in China are ready to pounce on the semaglutide market as soon as the patents expire in 2026. Half a dozen companies have launched late-stage clinical trials of semaglutide injections. One of them, Hangzhou Jiuyuan Gene Engineering, has completed late-stage clinical trials for its semaglutide biosimilar for treatment of type 2 diabetes, and could be the first to enter the Chinese market. A pending court decision on whether the semaglutide patent applies in China could see these drugs enter the market even sooner. Late-stage trials for the companys semaglutide biosimilar targeting weight loss are expected to start this year.

The arrival of semaglutide biosimilars will be a game changer and competition will be severe, says Lei.

Beyond biosimilars, companies in India and China are also developing new obesity drugs. For example, Mumbai-based Sun Pharmaceuticals has developed a molecule called GL0034 that has slight tweaks to its chemistry that distinguish it from semaglutide and alter the way it interacts with insulin-secreting cells and nerve cells, says Rutter, who is a consultant for the company. Not only is the ambition to have a cheaper product, but to have something which is as good, if not better than semaglutide, he says.

Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective

Early-stage clinical trials of GL0034 have been very encouraging, says Rajamannar Thennati, executive vice-president for Sun Pharma, who is based in Vadodara, India. The results in three dozen participants show that high doses can lead to body-weight reductions of up to 10% after two months, according to a press release, but Thennati says it could take up to five years for the molecule to hit the market.

Sun Pharma is also in the early stages of developing a dual-target drug to compete with tirzepatide. Its structure is sufficiently different to be proprietary, says Rutter.

Another improved drug could arrive in the Chinese market even sooner. Innovent has partnered with Eli Lilly to develop a molecule called Mazdutide that mimics both GLP-1 and the glucagon hormone, which stimulates glucose production. Glucagon helps to increase metabolism and enhances fatty-tissue burning. Results from late-stage clinical trials for Mazdutide will be announced at the American Diabetes Association meeting in Orlando, Florida, next week. Lei says they are positive. Preliminary data suggest some trial participants taking high doses lost some 19% of their body weight after close to a year. Lei expects that Mazdutide will be approved for weight loss by Chinas drug regulator in the first half of 2025, which would make it the first of this class of dual-target drugs to be approved globally.

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Cheaper versions of blockbuster obesity drugs are being created in India and China - Nature.com

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South Africas public health care system has run out of the human insulin pens that it provides to people with diabetes, as the pharmaceutical industry shifts production priorities to blockbuster weight-loss drugs that use a similar device for delivery.

Novo Nordisk, the company that has supplied South Africa with human insulin in pens for a decade, opted not to renew its contract, which expired last month. No other company has bid on the contract to supply 14 million pens for the next three years, at about $2 per pen.

Current manufacturing capacity limitations mean that patients in some countries, including South Africa, may have limited access to our human insulins in pens, said Ambre James-Brown, a spokeswoman for Novo Nordisk. The company did not reply to questions about which other countries are affected.

Novo Nordisks drugs Ozempic and Wegovy, which are widely prescribed in the U.S. for weight loss, are sold in single-use pens produced by many of the same contracted manufacturers who make the multidose insulin pens. A months supply of Ozempic in the United States costs about $1,000, far more than insulin.

Novo Nordisk dominates the global market for insulin in pens and has supplied South Africa since 2014. Eli Lilly, the other major producer, has indicated in recent months that it is struggling to keep up with the significant demand for its weight-loss drug Zepbound.

This is because of the global demand for Ozempic and these drugs, said Khadija Jamaloodien, the director of sector-wide procurement for South Africas health service. Theyre shifting the focus on the more profitable line.

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South Africa Runs Out of Insulin Pens as Global Supply Shifts to Weight-Loss Drugs - The New York Times

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QUICK-fix weight loss videos on social media have soared by nearly 300 per cent in the last 12 months and its having a detrimental impact on mental health.

An online analysis found there have been over eight million posts in 2024 alone about "burning fat quickly" on TikTok.

2

And Google searches for these types of quick fixes have increased by 581 per cent in the last 12 months.

However, a poll of 2,000 adults found 42 per cent admit that quick weight loss content makes them feel insecure and negatively impacts their mental health.

And 59 per cent agree celebrity and weight loss content is the worst thing on social media for their mental health.

The research was commissioned by ASICS as part of its 15 Minute Weight Loss campaign, showing just 15 minutes of exercise is enough to take the weight off our minds.

Professor Brendon Stubbs, a leading researcher in exercise and mental health from Kings College London, said: By becoming too focused on the short-term and often narrow possibility of losing weight, we are neglecting the profound and multifaceted benefits movement can have on our minds.

The fact is that weight loss is hard, and it takes time.

Many people stop exercising before this happens because they become despondent when quick weight loss is not visible, or in some cases not possible.

Instead, if people focus on doing exercise for enjoyment and the mental health benefits, people are not only protecting their minds but are also much more likely to remain engaged in exercise in the long term.

The analysis went on to reveal conversations online about exercise for mental health remain significantly less frequent.

The number of videos focused on exercise + weight loss has increased by 204 per cent this year, 33 per cent more than videos focusing on exercise + mental health.

As a result, 70 per cent agree weight loss content on social media doesnt motivate them to exercise.

And 80 per cent believe the focus on celebrity bodies negatively impacts self-esteem.

While a further 72 per cent believe societys obsession with the perfect body is bad for peoples mental health, figures revealed.

Psychologist Dr Tara Quinn-Cirillo added: "Evidence suggests that quick-fix weight loss, through diet and exercise fads, often leads to only short-term gains and negative long-term consequences.

The desire to lose weight quickly, perpetuated by societal norms and pervasive digital weight loss content, can be damaging to self-esteem and self-worth, as people strive for an ideal that society has cultivated.

The result can cause people to obsess overusing exercise only as a way to change appearances.

What often gets overlooked is the power of movement to support better overall health therefore, reframing our relationship with exercise is crucial.

Activities such as running, playing games in a park, or even going up and down the stairs are all movements that can contribute to overall improved wellbeing

Moving our bodies releases dopamine which boosts mood, reduces stress hormones like cortisol and adrenaline and has long-term benefits for anxiety reduction.

And we dont always need to engage in formal exercise for these benefits activities such as running, playing games in a park, or even going up and down the stairs are all movements that can contribute to overall improved wellbeing.

Gary Raucher from ASICS EMEA concluded: The increasing focus on exercise purely as a tool for weight loss is worrying.

Research shows that societys obsession with exercising for the perfect body is adding pressure and putting people off exercise.

Todays campaign is a crucial reminder for people to move for their minds, and not just for how it changes their bodies.

Weve always believed in the positive impact of movement, not just on the body, but also on the mind.

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Quick-fix weight loss videos boom online as insecure Brits slam burning fat quickly clips... - The Sun

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PERHAPS YOU'VE SEEN 30-30-30, the three-part morning routine touted as a weight loss miracle on TikTok. The straightforward approach to setting up your day focuses on the number 30 (obviously) and applies it to food and

The 30-30-30 plan isn't even really a diet, at least in the traditional sense, but more of a daily practice intended to lay the foundation for a solid morning and successful day. Though some proponents of 30-30-30 do argue that the approach can help you lose weight.

Can such a simple approach really help with weight loss? And does the whole 30-30-30 thing even check out scientifically? Let's dig in.

THE 30-30-30 PLAN blew up when biohacker Gary Brecka described it on TikTok, although the diet itself traces back to the 2010 book The Four Hour Body by Tim Ferriss. The method is simple: Eat 30 grams of protein within 30 minutes of waking up. Then, do 30 minutes of steady low-intensity cardio with your heart rate below 135 beats per minute.

Many social media influencers tout 30-30-30 as a weight loss strategy (Brecka has said hes never seen a diet strip fat off a human like this one.) The supposed mechanism on how 30-30-30 works for fat loss: by eating a protein-rich breakfast, you protect your muscles so you burn fat, not lean mass, during the workout that follows.

THAT'S KIND OF a complicated question, largely because while 30-30-30 is based in some key practices of good health, it also oversimplifies diet and exercise by leaving out a few critical components.

But let's start first with what makes sense.

Research suggests that high-protein diets can reduce body fat and maintain muscle mass by keeping you full and satisfied so you eat less overall. Experts recommend 1.2 to 1.6 grams of protein per day for every kilogram of your body weight.

So why not start with 30 grams first thing? 'This method allows us to get a good dose of protein first thing in the morning, potentially helping us meet protein goals throughout the day a little easier,' says Sarah Keathley, M.S., R.D., L.D., a nutritionist at Top Nutrition Coaching. A recent study review published in Nutrition Reviews even showed an association between high-protein morning meals and greater muscle mass.

While theres no magic to the 30-minute window for eating breakfast, eating early is probably a good idea. One recent study in BMC Nutrition showed that the earlier people ate after waking, the healthier their breakfast, perhaps because they werent crunched for time. Another study in the European Journal of Nutrition suggests that eating early is associated with better metabolic health, including insulin function, in men, perhaps because blood sugar processing is most efficient after a night of sleep.

A rule like this could keep you honest about exercise. As many of us are lacking in physical activity, this can be a benefit, especially getting active first thing in the morning before potentially sitting all day at a desk, says Keathley.

A less obvious benefit of the 30-30-30 plan is mindfulness, says Keathley. 'It gets you thinking about food, your nutrition plan for the day, how you can squeeze in exercise, and hopefully the quality of what you are eating,' she says.

That's all the good stuff. And it is good. But where 30-30-30 falls flat is science has not yet proven if there's any magic in the combination approach. More research is needed to show whether combining them this way works. 'There are no direct research studies that examine the exact 30-30-30 method and its effect on a group of individuals at this time,' says Keathley.

Plus, while 30-30-30 is simple and easy to remember, its simplicity could be a problem. Here are the drawbacks of the strategy.

'Although protein is an excellent macronutrient that our body needs to function, weight loss primarily stems from a calorie deficit,' says Keathley. 'During a calorie deficit, our body taps into stored fat as its source of energy, leading to weight loss.'

The 30-30-30 plan 'does not address whether each individual may need a different level of physical activity to best meet their own health needs,' says Keathley.

Low-intensity cardio has had mixed results in research studies. In a study published in Medicine and Science in Sports and Exercise, middle-aged people who did workouts similar to the steady light cardio in the 30-30-30 plan didnt lose weight over 24 weeks. Another study published in the journal Obesity showed that similar levels of exercise helped participants lose about six pounds in 12 weeks, but it didnt matter whether they worked out in the morning or at night.

'Exercise alone rarely leads to weight loss,' says Leanne Redman, M.S., Ph.D., F.T.O.S., a professor of clinical sciences at Pennington Biomedical Research Center, and there are several reasons as to why that is.

Your morning workout can only do so much. For one, if you dont track overall exercise and make adjustments to your diet, you can easily eat more calories than you burned. Plus, often when we burn calories in exercise, we burn fewer elsewhere through the day, 'so the net impact of exercise on daily calories is small for most people,' she says.

MAYBE? THE 30-30-30 diet probably isnt the secret to dramatic weight loss, but it could help you establish a healthy morning routine. 'Be cautious and when implementing any plan, fit it to your own lifestyle needs to make it realistic,' says Keathley. 'The end goal of any nutrition journey is to create healthy and sustainable habits.'

For high-quality breakfasts with at least 30 grams of protein, try the following:

If you arent a big eater in the mornings, protein drinks (whether ready-made or mixed up with protein powder) can help you hit 30 grams fast.

Every large egg has about six grams of protein. Pair a few with lean meat and a high-fiber grain to make it a complete meal. Or make egg bites. Create an omelet. The options are endless, says Keathley.

Pick a high-protein, low-sugar yogurt like non-fat Greek yogurt.

Add lean protein to oatmeal by mixing in egg whites, nut butter, nuts, seeds, quinoa, powdered peanut butter, or protein powder.

Julie Stewart is a writer and content strategist whose work has also appeared in Health, and Womens Health, Everyday Health, Vice, and Shape.

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Experts Explain the 30-30-30 Diet Plan: Does It Work? - Men's Health UK

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