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Packages of chocolate milk await shipment at Cambrooke Therapeutics's Ayer plant. See video at sentinelandenterprise.com. SENTINEL & ENTERPRISE / JOHN LOVE

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AYER -- A marvelous thing happened after a jeweler, her architect husband and her businessman brother put their heads together.

"We made a difference," Lynn Paolella said. "It really started with an inspiration to feed my kids."

Lynn and her husband David have three children, the two youngest, Cameron and Brooke, were born with a rare disease, phenylketonuria or PKU.

The only way to manage the disease that can cause intellectual disability and other health problems is a diet that minimizes exposure to phenylalanine, an amino acid in protein, yet provides enough protein for the body.

The amino acid is present in many foods, even things like potatoes. It is also a main ingredient of the sweetener Aspartame.

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Until 2009, the accepted treatment for the disease was based on synthetic protein without phenylalanine. "They protected our kids' brains," David Paolello said, but the diet was unpalatable.

Lynn set to work, developing recipes that her children would want to eat. "I love to cook and I absolutely loved the challenge of this low-protein diet," she said.

In 2000, those early attempts led to a new business, Cambrooke Therapeutics. It started out as a family business with just the Paolellas and Lynn's brother, Don Patterson. They developed the food, outsourced manufacturing and made connections all around the world.

Now, the Ayer-based medical food manufacturer is increasingly automated with clients across the globe.

Development of PKU treatment is covered under the Orphan Drug Act, David Paolella said. The act covers drugs and treatment for diseases affecting small numbers of people.

PKU, an inborn error of metabolism, occurs in about 1 in every 10,000 births in the United States. When caught at birth and managed successfully, the children can thrive. If left untreated, mental retardation results.

Sentinel and Enterprise staff photos can be ordered by visiting our SmugMug site.

The disease is easy to catch in newborns. The screening test for was developed by a Massachusetts doctor, Robert Guthrie, in the 1960s. His photo is on the wall of the ground floor conference room in Ayer.

Cambrooke is at the cutting edge of medical nutrition. In 2009, the University of Wisconsin Madison developed a way to make a protein without phenylalanine from whey, a cheese-making byproduct.

"They approached us," Lynn Paolella said.

The protein tasted better than the synthetic product. Cambrooke licensed the technology. A peer-reviewed study funded by the National Institutes of Health and the Food and Drug Administration, proved the safety and effectiveness of the protein.

Along the journey, the company worked with the Small Business Development Center at Clark University in Worcester.

They moved into a former electronics plant in Ayer, drawn to the area by the other beverage and food companies. The building required a multi-million dollar makeover to become a sterile place to manufacture and package beverages.

Food is made from scratch in Brockton, Lynn Paolella said.

The liquids products are put into sterile packaging, David Paolella said. The product will not spoil at room temperature. Nutrients in the liquid will degrade over time.

Their equipment is the only setup in the county that can turn out cost-effective, sterile packages in small batches of 20 to 30 cases, he said.

Sentinel and Enterprise staff photos can be ordered by visiting our SmugMug site.

Cambrooke makes food products for other inborn error of metabolism diseases. They also make high-fat food that can manage and sometimes even cure intractable epilepsy that is not controlled by drugs.

The products allow people who must follow strict diets in order to remain healthy the chance to live a life just like everyone else.

"In essence, we're a grocery store of products they can eat," David Paolella said. Some want flour to make cookies, others would rather have cookie dough to bake and some want packages of cookies.

When Cameron and Brooke, now 24 and 19, their older brother Bryce, 26, sit down to eat with the family, everyone might eat Cambrooke products.Or maybe not. (The PKU diet is vegetarian; mom and dad like their meat.)

Three hospitals where families are sent when after receiving a diagnoses of a disease that can be treated by diet are in Massachusetts. They go home with information about Cambrooke after their first visit.

Working with the Massachusetts Export Center and the U.S. State Department, Cambrooke established overseas markets. The incidence of PKU is higher in other countries.

They just met with a Chinese mother, who began manufacturing PKU-friendly food after her child was diagnosed. Until recently, if a child in China had PKU, there was no government help. Babies were left by the side of the road to die, Lynn Paolella said.

An export deal could be in the works. The market would be huge. The disease is more common there than it is in the U.S., she said.

The test kitchen, with two sinks, large ovens and seating for a crowd, sees everyone from groups of dieticians to families learning to deal with the restrictive diet. A playroom upstairs keeps little ones busy while older folks learn.

Enabling people and families to live with the diagnoses is another challenge Cambrooke took on.

Some of the diseases treated by diet must require lifelong management. An iPhone app helps patients keep track of their nutrition.

Cambrooke can bill insurers directly, making it easier for their clients.

Schools are required to supply special diets when needed. The school lunch program Lynn Paolella developed is used in about 400 schools, the closest one in Groton.

The meals need to be heated up and the child with a restricted diet can eat with friends.

Health-care benefits are not consistent across the country, David said. Some states do not even require newborn testing for PKU. The test might be sent out of state to be read. If the lab will includes PKU results, out-of-state health-care providers might not give them to parents.

Lynn went to Washington, D.C., to advocate for the Medical Food Equity Act, requiring insurance plans to cover formula and low-protein foods. The act died in committee.

The business remains a family business at heart. Bryce Paolella helped with developing a new product.

Lynn and David Paolella are the founders and work with the company daily.

Don Patterson is the vice president of operations.

Lynn and Don's mother gives the products her own blessing. Marilyn Patterson helps out with packaging; she plants a kiss and a prayer of goodwill in each box she prepares.

Follow Anne O'Connor on Twitter and Tout @a1oconnor.

Originally posted here:
Ayer company grows with food developed for those with disorder - Lowell Sun

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Diabetes is becoming an increasing concern nowadays and US with its increasing obesity is at high risk. Researchers are always looking for ways to reverse the effects. They just came up with an interesting approach where they were able to reverse the diabetes symptoms and restore pancreatic function in mice by putting them on something similar to a fasting-mimicking diet. So what does this diet actually do? The diet tricks the body in entering into a fasting mode for a few days each month even though selective food is being consumed. This, according to the researchers may be enough to reboot the pancreas functions including insulin production.

According the team from University of Southern California, this method was able to reverse the symptoms of both type I and type II diabetes. The head of the research team Valter Longo said, By pushing the mice into an extreme state and then bringing them back, the cells in the pancreas are triggered to use some kind of developmental reprogramming. The fast-mimicking diet has been used previously for humans for the purpose of losing weight and reducing risk factors for heart disease and cancer. This diet is earning great importance in the eyes of researchers as it has also helped in reducing symptoms of Multiple Sclerosis. It seems that starving the body is resetting the cells.

For this study, mice were put into a fasting mode for four days every week over a period of several months. It was observed that this process regenerated beta cells in the pancreas which basically store and release insulin. Scientists also experimented on cell cultures from human donors with type I diabetes. In this case as well it was observed that fasting produced more insulin and more of the Ngn3 protein which is necessary for normal and healthy pancreatic function.

The research is still in its early stages so scientists have warned not to use this at home to treat diabetes. The diet requires measured calorie intakes and can be effective only if certain types of food are consumed. It is hoped that in the future the fast-mimicking diet will be able to help treat diabetes. According to Longo, Scientifically, the findings are perhaps even more important because weve shown that you can use diet to reprogram cells without having to make any genetic alterations. The amazing thing is that this system has probably always been there. Now that weve discovered it, we can find ways to work with it and utilize it for benefits to human health.

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Fruits and vegetables are low in saturated fat. (Photo: Valeria Boltneva, StockSnap)

People dont want to be fat, so its natural for us to think we should avoid eating fatbut being healthy is never quite that simple, is it?

Ive talked a lot about various dieting strategies with a lot of focus on losing weight. Sometimes I think I do it too much, but the truth is theres so much new information out there. I think its important to stay on top of the new research while also keeping in mind what we already know (or thought we knew) about the dieting strategies that actually work.

With that in mind, a recent study caught my eye. Heres some information on it and why I think its so important.

One meal heavy in saturated fat can cause warning signs of Type 2 diabetes.The study I read examined the results of a massive amount of saturated fat on the body in a single sitting. Scientists took two groups of test subjects. One was given a glass of water to drink, and the other was given a flavored palm oil drink. The palm oil contained a similar amount of saturated fat as "two cheeseburgers with bacon and a large portion of french fries or two salami pizzas."

Scientists then studied the liver contents and insulin sensitivity in the test subjects to determine just how much it changed based off this single (massive) serving of saturated fat. What they found was that the changes were quite significant. Those who consumed the saturated fat saw an increased insulin resistance similar to what you would find in people with Type 2 diabetes, as well as an increased amount of fat content in the liver. Metabolic changes were also observed, meaning the subject's metabolism was slowed similar to what is seen in people suffering from "metabolic syndrome," which is another warning sign for the development of Type 2 diabetes.

What does this mean for you and me?There are a few ideas to keep in mind. First, the amount of saturated fat the subjects received was massive. It is significant that the researchers took healthy individuals and witnessed such dramatic effects in one go. However, its less surprising when you put the amount in perspective.

For instance, the average height of a man in the U.S. is about 5 feet 10 inches tall. The high end of a healthy body mass index for a man that tall is 173 pounds. So if that man is moderately active (exercises three to five times a week), he needs about 2,750 calories a day to maintain his weight. The amount of saturated fat the researchers were talking about here, specifically the two cheeseburgers and large fries, would roughly equal that same amount. That's a whole lot of fat packed into one serving. It shouldn't be a huge surprise that the effects were so dramatic, should it?

Secondly, and Ive touched on this before, the test subjects didnt sit down and actually eat two cheeseburgers and large fries. They were given a drink containing a similar amount of saturated fat. So there wasnt even a balance to the amount of unhealthy ingredients. Their bodies werent given a bunch of carbs, protein and fat all at once. They mainly got a massive amount of fat alone. Since eating healthy really is all about balance, no wonder their systems were thrown into chaos! Imagine if you ate 2,700 calories of soda water or 2,700 calories worth of protein powder in a single sitting.

I think wed all experience some pretty significant side effects, dont you?

Plenty of healthy foods have lots of fat.Look, I dont think the researchers for this study set out to terrify people. I also dont think what they ended up publishing is false. However, I do think its imperfect, simply because its information taken from one day's worth of data, and it wasnt put into proper perspective. Why? Probably because they get a flashier headline and more attention this way, but I just want people to remember this: Fat is not the enemy.Saturated fat isnt even necessarily the enemy. Too much saturated fat can be a problem for some people, but its all about your individual needs.

Right now, the vast majority of Americans are still consuming way too much added sugar. We need to keep the focus on lowering those numbers and continue balancing our diets with a mixture of carbohydrates, protein and fat. We should avoid foods like these, because only about 3 percent of Americans currently meet the four criteria for a "healthy lifestyle,"which is a good diet, moderate exercise, a recommended body fat percentage and being a nonsmoker.

Here are strategies to help prevent Type 2 diabetes.Remember, Type 2 diabetes and obesity are kind of like the chicken-or-egg argument of the health world. They both make the other issue harder to fix, and they both make the others side effects more severe. Heres an article I wrote discussing seven habits that cause people to fail to lose fat, and heres another article in which I specifically discuss how to combat and prevent Type 2 diabetes.

Being healthy and staying that way takes a lot of work. What I hope youll remember is that research is constantly evolving and new information is always on the horizon, but one particular study rarely (if ever) means we should throw what we already know out the window. Stay focused on your goals and be vigilant in your search for trustworthy health articles.

Jay McKenzie loves soccer, history and feeling great. He's on a quest to eat better and exercise more, and he wants to share his experiences along the way. You can email him at jaymckenzie86@gmail.com with comments or questions. The opinions expressed in this column belong solely to the author, not Nooga.com or its employees.

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Fresh and Fit: Why 1 meal high in saturated fat causes symptoms mimicking Type 2 diabetes - Nooga.com

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It wasn't vanity that drove 22-stone John Cox to swap slap-up meals for salads - it was his snoring.

Doctors diagnosed obstructive sleep apnoea when the burly bus driver sought help for the problem, and promptly told him to lose weight.

But the 34-year-old bus driver found it difficult to give up his favourite meat-feast pizzas and laboured on for another six years.

"I was that big, I could steer the bus with my belly," he said.

Until last February, that is, when he made the decision to go on a diet. Exactly 12 months on, John has lost nine stone by following a strict calorie-counting regime and joining a gym.

The divorced dad-of-two, who drives buses for Arriva across Wolverhampton, Cannock, Rugeley and Walsall, said: "It's been life-changing. Not only have I lost all this weight but I've stopped snoring."

John was simply embarrassed and exhausted by his loud snoring, having absolutely no knowledge of just how dangerous his condition was.

"I had tests at the County Hospital in Stafford, and the doctors told me I'd stopped breathing up to 93 times in an hour. I had no idea.

"The weight was a key aspect of it - all that fat around my neck was blocking up my airways. I'd wake up to go to work and feel like I'd had no sleep at all.

"It was the job that initially made me go for help. Obviously driving a public sector vehicle meant safety was at the forefront of my mind.

"Since 2010 I've been wearing an oxygen mask at work to keep me alert but to get it properly under control I realised I needed to lose weight. "

John also went through the break-up of a relationship which was another spur to changing his lifestyle.

"I needed to sort myself out," he said.

He embarked on the Cambridge diet, a highly structured eating programme that involves surviving solely on shakes, soups and nutrition bars that provide between 450 and 1,500 calories a day before substituting some of the products for low-calorie meals.

Dieters tend to shed weight quickly - up to a stone a month - particularly during the first step of the programme.

John lost weight steadily but it wasn't until he had shrunk to 15 stone that he introduced exercise into his regime.

He says: "I wouldn't go to the gym the way I looked. Being borderline morbidly obese, I was too conscious of my body. I started going when I felt more comfortable about my body. I had stretch marks but I could live with those. Now I'm at the gym three times a week."

John grew large on a daily intake of takeaways, his favourite being Domino's 12-inch meat feast pizza. He hasn't touched one since but owns up to having had a burger and chips for lunch that day.

"I don't have them every day but I have completely changed the way I used to eat. I'd get up and have no breakfast then feed up on bacon and cheese sandwiches, pizzas, always takeaways.

"I'd have high-calorie energy drinks to keep me awake but then my system would crash an hour later. I just didn't look after myself. Now I only drink water and coffee."

John, who lives in Shareshill, near Featherstone, came in for some teasing at work over his weight but took it in good part. "I like that banter, I can take it."

Now he is a slim 13 stone and still losing weight, the jokes are no longer on him. But the real bonus of shedding so much weight has been that he can play with his children, six-year-old Oliver, and Mia, aged four.

"I can be a proper dad now, and they're really happy with the new me," he said.

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'I was that big, I could steer the bus with my belly': Driver John ditches the pizza to lose nine stone - expressandstar.com

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Enlarge / These mice are about to have issues.

In mice with either type I or type 2 diabetes, an intense, four-day fasting diet seemed to regenerate pancreas cells and restore insulin production. Researchers reported this finding on Thursday in Cell.

In Petri dish experiments, human pancreas cells from patients with type 1 diabetes also showed altered gene expression and kick-started insulin production after being exposed to blood from people on a fasting diet.

The results of the early work are promising for potential dietary treatments of both types of diabetes. Type I is caused by a loss of insulin production, while type 2 is caused by diminished production or insensitivity to insulin, a hormone that triggers the breakdown of sugar in the blood.

But the research needs to be verified. Far more work in humans needs to be done before researchers can make any sort of conclusions or treatment recommendations. Experts warn that trying out the diet could trigger dangerous complications in diabetic patients.

It boils down to do not try this at home, Dr. Valter Longo, lead author of the study and a researcher at University of Southern California, told the BBC. This is so much more sophisticated than people realize.

The mice were given a low-calorie, low-protein, low-carbohydrate, high-fat diet for four days. On the first day, the mice could only eat 50 percent of their normal calorie intake. For the remaining three days, the mice ate just 10 percent. Next, they got up to 10 days of normal eating, which allowed them to regain lost weight, before another four-day fast. The mice went through this cycle three times.

Mice that model type I diabetes saw a boost in their pancreatic beta cells, which generate insulin. In mice modeling type 2 diabetes, researchers saw restored insulin production and reduced insulin resistance.

"This is good science and does give promise for the future treatment of diabetes, immunologist Anne Cooke of the University of Cambridge told the NHS. But we need further studies to see whether this works in people as well as it has in mice."

Cell, 2017. DOI: 10.1016/j.cell.2017.01.040 (About DOIs).

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A fasting-diet may trigger regeneration of a diabetic pancreas - Ars Technica

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If you're thinking of ending a diet, take a page fromHugh Jackman's menu.

After 17 years, the actor starred asWolverine for the ninth and last time (allegedly) in theX-Men spinoff filmLogan, which is set for release on March 3. He appeared on NBC'sTonight Show Starring Jimmy Fallon Friday to talk about the movie. While backstage in his dressing room, he decided to have a little snack.

Make that a humongous snack. Make that theWolverine of snacks. He posted on his Instagram page a photo of himself holding a fettuccine dish large enough to feed a whole group of X-Men, courtesy of celebrity chefMario Batali.

"Happy Break The Wolverine Diet! @mariobatali you are legend! @jimmyfallon @wponx @20thcenturyfox," Jackman wrote.

"The new @thehughjackman #wolverine diet includes pasta. lots of pasta," Batali said.

The photo also showed a smaller plate with a mostly eaten portion of pasta sitting alongside a glass of red wine. Now that's a way to break a diet!

Jackman said onThe Tonight Show that his Wolverine diet consisted of boiled chicken, broccoli and cauliflower.

"It's not like I never had a cheat meal, 'cause I did," the actor said. "But for 17 years, I've kind of known, 'Well, next year, you gotta get into shape...' It kind of puts a bit of a damper on things."

Jackman also said he sought advice from his friendJerry Seinfeld about whether to stop playing Wolverine.

He said he asked the comedy actor and comic why he decided to endSeinfeld when he did.

"He was very clear," Jackman said. "He said, 'Look, when you're creating something, it's very important not to run yourself dry. It's not about finishing on top, necessarily, but making sure that you creatively still have something left, which propels you into whatever's next.'And as he was talking to me, I went home and I said [to my wife], 'Deb, this is it. This is the last one.'"

(E! and NBC are part of the NBCUniversal family.)

E! Online - Your source for entertainment news, celebrities, celeb news, and celebrity gossip. Check out the hottest fashion, photos, movies and TV shows!

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Referring to heart disease, Dr. Caldwell B. Esselstyn, Jr., MD, asks, Why is there reticence to provide the public with guidelines that will spare them this disease or its progression? in an article published in The American Journal of Cardiology. The National Research Council position was that a dietary fat recommendation lower than 30 percent would be too frustrating for those attempting to achieve a significant reduction. Although it is uncertain to what extent people will adopt the advice, it is nevertheless scientifically and ethically imperative to inform the public what constitutes an optimal diet. We must tell the public the truth about what is best for their health, and let them decide their degree of compliance, he asserts.

My video belowexplains how Dr. Esselstyn challenged an expert panel to answer these questions from patients: Ill do anything, but I never want to have heart disease and Ive had a heart attack, and I never want another. Answers ranged from having them eat beans, beans, and more beans to time for the public to embrace a plant-based diet.

The recommended plant-based diet is not the same as vegetarianism. Vegetarians often consume all sorts of less-than-healthful foods, such as oils, margarine, dairy products, and eggs. Vegans do, too, for that matter. This new paradigm is exclusively plant-based nutrition, Dr. Esselstyn explains. In other words, it consists only of whole plant foods. Why exclusively? Because, as reported in the Cornell China Study, there does not appear to be a threshold beyond which further benefits do not accrue with increasing proportions of plant-based foods in the diet. It appears the more plant-based foods and the fewer animal-based foods, the better.

In a separate paper published in The American Journal of Cardiology, Dr. Esselstyn acknowledges that he is acutely aware of the castigation that accompanies recommending a plant-based dietnamely that the recommendation will be met with skepticism and hostility on the part of the general publicthough less so these days as millions jump on the plant-based wagon. But that hostility is peculiar, Dr. Esselstyn continues, because many cultures sustain themselves with such a diet, enjoying its taste, texture, and variety, as well as its health-promoting qualities. However, dietary preference is deeply personal, and one can easily be offended. Nevertheless, the public has a right to know the truth as understood by experts in nutritive biology about what constitutes the safest and healthiest diet. I couldnt have said it better. The public has a right to know the truth.

Some criticize this exclusively plant-based diet as extreme or draconian. Websters dictionary defines draconian as inhumanly cruel. A closer look reveals that extreme or inhumanly cruel describes not plant-based nutrition, but the consequences of our present Western diet, Dr. Esselstyn writes, adding that having a breastbone sawed in half for bypass surgery or a stroke that renders one an invalid unable to speak can be construed as extreme, and having a breast, prostate, colon, or rectum removed to treat cancer may seem inhumanly cruel. Thats extreme.

In health,

Michael Greger, M.D.

PS: If you havent yet, you can subscribe to my free videoshereand watch my live, year-in-review presentations2015:Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet, and my latest, 2016:How Not to Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers.

Related:

Why was Heart Disease Rare in the Meditteranean? How to Eliminate 90% of Heart Disease Risk Can Oatmeal Reverse Heart Disease?

Disclaimer: The views expressed above are solely those of the author and may not reflect those of Care2, Inc., its employees or advertisers.

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Home General Health Bladder Nephrotic syndrome (a kidney disease): Causes, symptoms, treatment, and diet

Nephrotic syndrome is a kidney disorder that results from the release of too muchprotein in the urine. When damage is caused to the blood vessels within the kidneys, which filter waste and water, it can lead to nephritic syndrome. Nephrotic syndrome leads to swelling of the feet and ankles, along with other health conditions as well.

To treat nephritic syndrome, its important to treat the underlying health issue causing it. Because nephrotic syndrome can lead to other complications, its important to begin treatment right away.

Damage to the blood vessels, which filter water and waste, is the primary cause of nephrotic syndrome. When these vessels are healthy they keep the appropriate amount of protein in the body and expel the extra. When they are damaged too much protein leaves the body through the urine.

There are many causes of blood vessel damage, including:

Symptoms of nephrotic syndrome include:

The factors that increase your risk of developing nephrotic syndrome include kidney damage due to medical conditions like diabetes or lupus, use of medications like nonsteroidal anti-inflammatory drugs, and infections like HIV, hepatitis B and C, and malaria.

The complications that may arise due to nephrotic syndrome include blood clots, high cholesterol, poor nutrition, high blood pressure, acute kidney failure, chronic kidney disease, and an increased risk of infections.

There are three main ways to test and diagnose nephrotic syndrome: urine test, blood test, and kidney biopsy. A urine test will reveal abnormalities found in the urine including protein. A blood test will reveal low levels of protein and high levels of cholesterol, and a kidney biopsy will take a small tissue sample from the kidney and test it.

Treatment for nephrotic syndrome involves treating the underlying condition; therefore, treatment may include:

Its important to change your diet if you have nephrotic syndrome because unhealthy foods can further damage the kidneys. For starters, choose leaner sources of protein or even plant-based protein; it isnt as taxing on the kidney. You will also want to reduce the amount of fat and cholesterol in your diet to control cholesterol levels and reduce your risk of heart disease, which can worsen nephrotic syndrome. Lastly, reduce your salt intake to minimize swelling.

http://www.mayoclinic.org/diseases-conditions/nephrotic-syndrome/basics/complications/con-20033385

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Nephrotic syndrome (a kidney disease): Causes, symptoms, treatment, and diet - Bel Marra Health

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Women's Health

'I Lost 30 Pounds After Trying The Whole30 DietHere's How I Did It' Women's Health I would try a new workout, do it for two weeks straight, and not work out again for another three months. I was the same way with my diet. I'd eat salad and smoothies for a week before a trip to Vegas, but then I'd go right back to the junk the week ...

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'I Lost 30 Pounds After Trying The Whole30 DietHere's How I Did It' - Women's Health

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Forbes

Oscar Nominee Gift Bag Includes Vaginal Fitness Tracker And Butt Mats Forbes If you were not nominated for an Oscar this year, here's what you'll be missing: an Everyone Wins Nominee Gift Bag. According to a press release, as it has for the past 15 years, Distinctive Assets, an entertainment marketing company, will be giving ... and more »

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Oscar Nominee Gift Bag Includes Vaginal Fitness Tracker And Butt Mats - Forbes

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