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OverviewWhat is unexplained weight loss?

Unexplained weight loss is a noticeable drop in body weight that occurs even if the person is not trying to lose weight. The weight loss does not come about because of diet, exercise or lifestyle changes. Weight loss of 10 pounds or more, or five percent of body weight, over a period of 6 to 12 months is considered unexplained.

Unexplained weight loss can be a symptom of a serious condition or illness. For this reason, it is important to seek medical attention if you (or a family member) have weight loss that cannot be explained.

Unexplained weight loss can occur in anyone. However, it is most common (and most serious) in people who are over the age of 65. Even unexplained weight loss of less than 5 percent of body weight or 10 pounds may be the sign of a serious condition in older people.

Unexplained weight loss can be caused by conditions that range from mild to very serious. The causes can be physical or psychological, and include:

You should consult your physician if you have lost more than 5 percent of body weight or 10 pounds without trying in a period of 6 to 12 months. This is especially important if you have other symptoms, too.

To diagnose your weight loss, your doctor will give you a physical examination and ask you such questions as:

The answers to these questions will help your doctor determine if other tests might be needed, such as blood work and imaging scans (X-rays, etc.).

Unexplained weight loss is treated by identifying the underlying condition (the condition or illness that is causing the weight loss). If no underlying condition is identified right away, your doctor may recommend a wait-and-see approach, along with a special diet.

For instance, your doctor may recommend that you use nutrition shakes to get more calories, or add flavor enhancers to your food to improve the taste so that you eat more. You may be also be referred to a dietitian for advice and counseling.

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Unexplained Weight Loss: Causes, Treatments - Cleveland Clinic

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If you've tried and failed to lose weight, a visit to your GP surgerycouldhelp.

Your GP or practice nurse can:

First, your GP or practice nurse will want to assess whether your current weight is healthy or not. This means measuring your weight and height to calculate your body mass index (BMI).

You may also have your waist measured. Measuring your waist is a good way to check you're not carrying too much fat around your stomach, which can raise your risk of heart disease, type 2 diabetes and stroke.

You can have a healthy BMI and still have excess tummy fat meaning you're still at risk of developing these diseases.

Your GP may take your blood pressure and carry out other tests, such as a blood test, to check for any health conditions that may be related to your weight.

You can also check your BMI by using our BMI calculator.

If you're overweight, changes to your diet and physical activity levels are the first step to helping you lose weight.

Your GP or practice nurse can help you assess your current diet and levels of physical activity, and set personalgoals for change.

You may be asked tokeep a food diary a written record of everything you eat for 1 week.

This can help you and your GP identify habits, such as adding sugar to your tea, that you can change.

Your physical activity levels can be measured with an activity diary.

Your GP may also suggest that you wear a pedometer for a week. A pedometer measures the number of steps you take and gives an indication of your daily activity levels.

Once your GP or practice nurse has a clearer picture of your diet and level of physical activity, they can help you identify simple lifestyle changes.

Together, youwill work out a game plan to lose weight healthily and for the long term. It'll be a plan tailored toyour lifestyle and your preferences.

Your GP surgery should offer you regular follow-up appointments, usually every 2 weeks to a month, to monitor your progress.

More weight loss resources:

Your GP surgerymay refer you to other services, such as local weight loss groups. These could be provided by the NHS, or may be commercial services that you pay for.

If it's appropriate, you may be referredfor exercise classesunder the supervision of a qualified trainer.

Depending on where you live, the exercise programme may be free or offered at a reduced cost.

If you've made changes to your diet and levels of physical activity but you're not losing a significant amount of weight, your GP may recommend medicines that can help.

Medicines are only used if your BMI is at least 30, or 28 if you have other risk factors such ashigh blood pressure or type 2 diabetes.

The only medicine prescribed for weight loss is Orlistat. For more information on weight loss medication, see Obesity: treatment.

If lifestyle changes and medicines don't work, your GP may talk to you about weight loss surgery.

Weight loss surgery is usually only recommended for people with aBMI of at least 40, or 35 if you have a weight-related health condition, such as type 2 diabetes or high blood pressure.

Weight losssurgery can be effectivebut it's a major procedure that comes with health risks of its own.

Find out about the different types of weight losssurgery.

In this video, Elinor describes how she lost weight with the help from her GP.

Media last reviewed: 1 June 2021Media review due: 1 June 2024

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How your GP can help you lose weight - NHS

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The Importance of Weight Loss and Exercise

Carrying around too much weight feels uncomfortable, and it can also damage your health. According the Centers of Disease Control and Prevention (CDC), obesity rates have skyrocketed in the United States in recent years. As of 2010, more than one-third of American adults have obesity, defined as having a body mass index (BMI) of 30 or higher. Body mass is derived by dividing weight in pounds by height in inches squared, and then multiplying the result by 703 (weight (lb) / [height (in)] 2 x 703). You can calculate your body mass by following these three steps:

Obesity can lead to a number of serious health problems, including heart disease, diabetes, stroke, and some types of cancer.

One method that can help a person lose weight is to limit the number of calories taken in through their diet. The other way is to burn extra calories with exercise.

Combining exercise with a healthy diet is a more effective way to lose weight than depending on calorie restriction alone. Exercise can prevent or even reverse the effects of certain diseases. Exercise lowers blood pressure and cholesterol, which may prevent a heart attack.

In addition, if you exercise, you lower your risk of developing certain types of cancers such as colon and breast cancer. Exercise is also known to help contribute to a sense of confidence and well-being, thus possibly lowering rates of anxiety and depression.

Exercise is helpful for weight loss and maintaining weight loss. Exercise can increase metabolism, or how many calories you burn in a day. It can also help you maintain and increase lean body mass, which also helps increase number of calories you burn each day.

To reap the health benefits of exercise, it is recommended that you to perform some form of aerobic exercise at least three times a week for a minimum of 20 minutes per session. However, more than 20 minutes is better if you want to actually lose weight. Incorporating just 15 minutes of moderate exercise such as walking one mile on a daily basis will burn up to 100 extra calories (assuming you dont consume excess calories in your diet afterwards). Burning 700 calories a week can equals 10 lbs. of weight loss over the course of a year.

To receive all of the health benefits of exercise, youll need to mix in some higher intensity exercises. To get an idea of how hard you are working, you can check your heart rate. The basic formula for determining your target heart rate is to subtract your age from 220 and then calculate 60 to 80 percent of that number.

Talk to a trainer or your healthcare team to help you determine your best intensity for each workout. Those with special health concerns such as an injury, diabetes, or a heart condition should consult a physician before beginning any fitness program.

The type of exercise you choose for weight loss doesnt matter as much as whether or not youre doing it. Thats why experts recommend you pick exercises you enjoy, so that youll stick to a regular routine.

No matter what exercise program you implement, it should include some form of aerobic or cardiovascular exercise. Aerobic exercises get your heart rate up and your blood pumping. Aerobic exercises may include walking, jogging, cycling, swimming, and dancing. You can also work out on a fitness machine such as a treadmill, elliptical, or stair stepper.

A big advantage of working out with weights is that, in addition to shedding fat, youll build muscle. Muscle, in turn, burns calories. Talk about a healthy feedback loop! Experts recommend working all the major muscle groups three times per week. This includes:

Yoga is not as intense as other types of exercise, but it can help you lose weight in other ways, according to a recent study by researchers at the Fred Hutchinson Cancer Research Center. The study found that people who practice yoga are more mindful about what they eat and, therefore, less likely to have obesity.

The total amount of exercise you engage in during a day matters more than whether or not you do it in a single session. Thats why small changes in your daily routine can make a big difference in your waistline.

Healthy lifestyle habits to consider include:

The average adult male who doesnt exercise requires approximately 2,200 calories a day to maintain his average weight. A female needs about 1,800 calories to maintain her weight.

The following list contains common activities and the approximate amount of calories burned per hour:

Activities

Calories Burned

playing baseball, golf, or cleaning the house

240 to 300

brisk walking, biking, dancing, or gardening

370 to 460

playing football, jogging (at a nine-minute-mile pace), or swimming

580 to 730

skiing, racquetball, or running (at a seven-minute-mile pace)

740 to 920

Talk to your doctor before you start a new exercise program, especially if you are planning on doing vigorous exercise. This is especially important if you have:

People who have been very inactive for the recent months, who are overweight, or have recently quit smoking should also talk to their doctors before staring a new exercise program.

When you are first starting a new exercise program, its important to pay attention to the signals your body is giving you. You should push yourself, so that your fitness level improves. However, pushing yourself too hard can cause you to injure yourself. Stop exercising if you start to experience pain or shortness of breath.

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Exercise and Weight Loss: Importance, Benefits & Examples - Healthline

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Effective treatment of adult-onset growth hormone insufficiency: Sermorelin is an effective and attractive treatment of adult-onset GH insufficiency. Unlike rhGH, sermorelin does not stimulate IGF-1 production in the liver and instead stimulates the pituitary gland to produce and secrete endogenous hGH, giving it a number of clinical advantages over exogenous hGH.

Notably, according to a 2006 article by Richard Walker, overdoses of endogenous hGH are difficult if not impossible to achieve as the effects of sermorelin are regulated by negative feedback involving the inhibitory neurohormone, somatostatin.

Sermorelin is not associated with the pro-cancer and pro-diabetes side effects linked to long-term hGH therapy, and is thus heavily researched to treat adult-onset GH insufficiency along with being used in longevity medicine for preserving youthful anatomy and physiology [5].

Positive effects on body composition: Sermorelin has been identified as one of several growth hormone secretagogues (GHS) that can help manage body composition in hypogonadal males. In a 2020 paper, Deepankar et al. noted that sermorelin can significantly improve body composition (in hypogonadal males) while ameliorating specific hypogonadal symptoms such as fat gain and muscular atrophy [6].

While the authors suggest that sermorelin could be used to achieve lean mass gain in both hypogonadal males and men with subclinical hypogonadism, to date, there is no published research that has investigated sermorelins effect on body composition in healthy subjects, highlighting an area for further research.

Potential anti-aging benefits: A 1992 study identified sermorelins potential anti-aging benefits after nine young male test subjects (22 to 33 years old) and ten elderly male test subjects (60 to 78 years old) were administered the peptide. The study found that short-term subcutaneous sermorelin injections enabled healthy male test subjects to reverse age-related decreases in GH and levels of IGF-I [7].

A 1997 single-blind randomized placebo-controlled trial found that elderly male and female test subjects who received nightly subcutaneous injections of sermorelin for 16 weeks experienced a significant increase in skin thickness. The peptide was found to produce significant increases in lean body mass in male test subjects and notable increases in libido and wellbeing. Male test subjects gained an average of 1.26 kg of lean body mass by the end of the trial [8]

Sermorelin and heart health: Sermorelin has been investigated alongside other GHRH agonists as a potential treatment for myocardial infarction scarring in swine [9]. The 2015 study found that sermorelin offered a number of benefits in post-heart attack animal models, which included:

As a result, there is research interest in sermorelins heart health-related benefits, namely in its potential to treat problems resulting from cardiac remodeling and ability to heal damage in myocytes following a heart attack.

See the article here:
Sermorelin | Reviews, Dosage & Clinical Trials - Peptides

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Juicing is an easy way to consume lots of nutrients without having to eat whole fruits and vegetables. Many people claim its a helpful weight loss tool.

The juicing diet trend has increased in popularity over the years, but its effectiveness is controversial.

This article will explore whether juicing can really help you lose weight.

Juicing is the process of extracting the liquid from fruits and vegetables while removing the solids. This can be done by hand or with a motor-driven juicer.

The juice from fruits and vegetables doesnt contain any skin, seeds, or pulp. It does contain some nutrients and antioxidants, but without the beneficial fiber of whole fruits and vegetables (1, 2, 3).

Some people use juicing as a detox method. However, there are no scientific studies showing that replacing solid food with juice will detoxify the body.

People also use juices as nutrition supplements and to lose weight. However, while juices can be rich in some nutrients, drinking juice exclusively is not a healthy and sustainable way to lose weight.

In general, juice recipes contain the juice of fruit and vegetables. Common recipes are made with carrots, celery, spinach, apples, oranges, wheatgrass, or combinations of these. Many also contain spices such as turmeric and ginger.

Juicing involves extracting the liquid from fruits and vegetables. People drink this juice to detox, to add nutrients to their diets, and/or to lose weight.

There are several types of juice diets available. The most common type is a juice fast, in which people replace their meals with juiced fruits and vegetables.

The point is to lose weight by abstaining from solid food while still ingesting a significant amount of nutrients from the juice.

Generally, these diets are very low in calories.

Some people do juice fasts for just a few days, while others go on them for weeks at a time.

Unfortunately, the effectiveness of juice diets is not well studied, but many people claim they produce quick weight loss.

To lose weight, you must maintain a calorie deficit, which means you consume fewer calories than you burn (4).

Many juice diets lack solid food and are extremely low in calories. This results in a large calorie deficit for many people, so juice diets do often lead to weight loss, at least in the short term (5).

However, once your calorie intake goes back to normal after the juice diet, youll likely regain some of the weight, if not all.

Since juice-only diets lack solid foods, you might find yourself feeling hungrier than usual when following this type of regimen.

This is because liquid meals, especially those that are high in carbs, are less filling than solid foods (6, 7).

Solid foods are more filling because they contain fiber and protein, which are both important nutrients that have appetite-reducing properties (8).

Fiber can reduce appetite because it may slow down the emptying of the stomach and increase digestion time (9).

Meanwhile, protein increases the levels of hormones that signal fullness, which are essential for appetite regulation (10).

The severe calorie deficit that many juice diets cause can have a destructive effect on your metabolism.

These diets are characterized by rapid weight loss and limited protein intake, which may lead to reduced muscle mass (11).

Muscles are metabolically active, so individuals with a lower muscle mass have a lower resting energy expenditure. This means they burn fewer calories at rest than those with more muscle (12).

Additionally, your body senses starvation when you dramatically reduce your calorie intake, so your body acts to preserve calories by burning fewer of them (13).

Controlled studies have confirmed this effect in individuals who follow calorie-restricted diets (14).

In one study, women with overweight or obesity who underwent a calorie restriction treatment for 3 months experienced a significant reduction in resting energy expenditure during that period (14).

While a calorie deficit is necessary for weight loss, it appears that low calorie diets, including juice fasts, may be counterproductive due to their negative effects on metabolism.

Juice diets are typically severely calorie-restricted and may not be filling. They may also affect your metabolism.

Juicing is generally safe if you do it for only a few days at a time. Additionally, fresh fruit and vegetable juices are a fine addition to a healthy diet as long as you truly enjoy them and you dont drink excessive amounts of juices that have added sugar.

However, juice fasts do carry some risks when they are prolonged.

Whole fruits and vegetables are excellent sources of fiber, but most of the fiber is removed in the juicing process.

Fiber is an essential part of a healthy diet. Eating enough of it is important for optimal digestion because it keeps the beneficial bacteria in your gut healthy and may reduce constipation for some people (15).

Additionally, it may lower your chances of heart disease, diabetes, and obesity (15).

When participating in juice fasts, you significantly reduce your fiber intake, which may result in health problems.

There are a few reasons why doing juice fasts for long periods may lead to nutrient deficiencies.

Since these diets lack animal products, they are low in a few essential nutrients, such as calcium, vitamin D, iron, vitamin B12, and zinc (16).

All these nutrients have important functions in the body. Inadequate consumption may lead to health conditions such as osteoporosis and anemia (17, 18).

Juice fasts are also low in omega-3 fatty acids, which are healthy fats that fight inflammation and contribute to brain and heart health (16).

In addition to being low in specific nutrients, these diets may actually interfere with the absorption of the nutrients.

One reason for this is that juice diets tend to be low in fat, which is required for the absorption of the fat-soluble vitamins A, D, E, and K (19).

Plus, some raw vegetables often used in juicing contain an antinutrient called oxalate, which can bind to minerals in your body and prevent them from being absorbed. In rare cases, high levels of oxalates may cause kidney damage (20, 21).

Oxalate-rich vegetables commonly used in juicing include spinach and other greens, such as beet greens, kale, beets, Swiss chard, and turnip greens (22).

Due to the minimal protein and inadequate amounts of some important nutrients in a juice diet, following one for a long time can impact your immune system and increase your risk of infection.

Depletion of immune-enhancing nutrients, such as iron, vitamin D, and zinc, may impact immune system health (23).

When your immune system is compromised, you may catch illnesses such as colds and the flu more easily. It may also take longer for your body to heal wounds.

Fatigue and weakness are common side effects of following a juice fast.

These symptoms are likely to occur because of the low number of calories these diets contain. If youre depriving your body of calories, youre essentially depriving it of energy, which can lead to these undesirable effects.

The minimal amount of protein in most juice fasts may lead to a reduction in lean muscle mass, which can have a negative effect on health (11).

As your lean muscle mass decreases, your metabolism decreases as well, meaning you will burn fewer calories and may have a more difficult time maintaining weight loss (11).

Juicing is generally safe, but following a juice-only diet for a long time may have a negative effect on your health and well-being.

There is no formal research to support the idea that juicing helps with weight loss.

Based on anecdotal evidence, its clear that juice diets may lead to rapid weight loss in the short term, especially when they are very low in calories.

However, you could experience some negative health effects from such severe calorie restriction, especially if you follow the diet for more than a few days at a time.

Additionally, its difficult to sustain such a restrictive diet. Most people do not stick with very low calorie diets for long and end up gaining back the weight theyve lost (5).

Juicing may be an easy way to lose weight quickly, but its potential health consequences seem to outweigh its benefits.

Youre better off following a more sustainable diet that includes whole foods and enough calories to keep your body functioning properly.

While juicing may result in short-term weight loss, its not sustainable and may lead to health complications if followed long term.

Fresh fruit and vegetable juices are tasty and nutrient-rich, but theyre not filling because theyre low in fiber and protein.

Juice fasts, although a popular choice for dieting, are not sustainable and may lead to health complications if followed for a long time.

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Can Juicing Help You Lose Weight? - Healthline

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