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Jan 22

Weight Loss Surgery Advantages Emphasized in New Zealand Woman’s 175 Pound Weight Reduction, says Beverly Hills Physicians – PR Web

The medical group has locations throughout the Greater Los Angeles area and beyond.

LOS ANGELES (PRWEB) January 20, 2021

A December 18 article on 9Honey reports on a 27-year-old woman in New Zealand who was able to shed an astonishing 176 pounds after undergoing weight loss surgery. The patient, Claire Burt, said she battled eating disorders, depression, and isolation as a result of her excessive weight but was unable to slim down despite frequent dieting and medication. The article reports that Ms. Burt was finally able to receive gastric sleeve surgery in April when 80% of her stomach was removed. Ms. Burt stated that since the surgery, she hasnt faced any obsessive thoughts over food, and her mental state has significantly improved. Health and beauty medical center Beverly Hills Physicians says that losing weight and successfully keeping it off long term can be difficult to achieve naturally, and getting medical assistance for a healthier and better quality of life simply makes sense.

Beverly Hills Physicians says that, while most people have less weight to lose, what Ms. Burt experienced while attempting to lose weight on her own is exactly what many severely obese individuals face. The clinic says that, while it is possible for some people to lose weight naturally on their own, keeping the weight off is nearly always unsustainable because the body fights what it perceives as the threat of starvation. Beverly Hills Physicians says that, because the body becomes accustomed to receiving a certain number of calories every day, it sends hunger signals to the brain in an attempt to encourage the individual to eat more when that intake is significantly reduced.

The health and beauty medical group says that this is why medical intervention is often necessary to lose and maintain a healthy weight for those fighting obesity. By removing a portion of the stomach in such procedures as sleeve gastrectomy, the hormone center responsible for sending the hunger pangs is often minimized. In addition, Beverly Hills Physicians says that, with a drastically smaller stomach, patients are only able to eat smaller portions comfortably, further helping individuals maintain weight loss.

The bariatric center adds that when patients can lose a significant amount of weight, they are not only reducing the likelihood of developing health issues such as diabetes or cardiovascular disease, but they are also improving their overall quality of life. Mobility, energy levels, and more can all be subtle benefits of losing significant amounts of weight.

Readers interested in learning more about weight loss surgery or any other of Beverly Hills Physicians offerings can call 1-800-788-1416 or visit the health groups website at https://www.beverlyhillsphysicians.com/.

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Jan 22

‘We Just Started To Hear Horrific Stories’: New Report Details ‘Devastating Effect’ Of Long-Term Care Closures – Fronteras: The Changing America Desk

Nearly 11 months have passed since nursing homes closed their doors to visitors because of the coronavirus pandemic. Some states, including Arizona, have resumed family visits under certain circumstances. Now, a new report highlights what some family members discovered once they were allowed back in.

The report is titledThe Devastating Effect of Lockdowns on Residents of Long Term Care Facilities During Covid-19.because thats what it was.

Sam Brooks is an attorney with theConsumer Voice, which represents long-term care consumers. They released the report.

"As soon as nursing homes locked down, we realized there was going to be a crisis," he said.

Thats because many long-term care facilities are understaffed.

"And a lot of homes relied on family members,"Brooks said.

Because family often help fill those caregiving gaps. They might help feed or groom their loved one, or simply provide companionship. In some ways says Brooks, it was like facilities lost another set of staff when families were locked out. After the lockdown, months and months went by before they were allowed back in.

"And we just started to hear horrific stories of significant weight loss. Residents wearing other people's clothes, their nails being long, dentures being not cleaned for months, just these horror stories, and a lot of times residents don't even recognize their loved ones anymore," saidBrooks.

Dana Kennedy is the state director for AARP Arizona.

"Unfortunately, there's nothing in the report that does shock me. It's all things that we were hearing. It's fairly common," saidKennedy.

And with such a high percentage of COVID-19 deaths occurring among long-term care residents nationwide, Kennedy is calling on the Arizona Legislature to make this issue a priority. Unfortunately, that looks unlikely. And Kennedy knows that.

"It wasn't their priority afterHacienda. And the elected officials should be absolutely embarrassed that this is not a priority,"Kennedy said.

EDITOR'S NOTE: The story has been updated to correct a quote by Sam Brooks regarding residents' clothing.

Get The Latest News On COVID-19 In Arizona

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'We Just Started To Hear Horrific Stories': New Report Details 'Devastating Effect' Of Long-Term Care Closures - Fronteras: The Changing America Desk

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Jan 22

To diet or not to diet? That is the question – leader-call.com

With the holiday season gone, many of us are taken aback looking at our waist line or stepping on the bathroom scale. And we make the annual vow to go on a diet. The question is which one.

The internet, newspapers and bookstores are filled with advice, articles and new or old diet book releases. What is a consumer to do?

The first impulse is to reach for a diet that promises rapid weight loss of 15 to 20 pounds in a week, such as the 10 Day Green Smoothie Cleanse, which placed number 3 on the best seller list for diets for 2020.

Never mind that the US News and World Report ranked the Mediterranean diet as No. 1, but with the latter, the weight loss is gradual and depends on adhering to it for a long time. It seems that we are stuck in the fast food/instant gratification rut. Losing weight and keeping it off demands effort and adherence.

For starters, any diet undertaken, be it the grapefruit or cabbage diet of yesteryear, will result in some weight loss, mostly due to the fact that one becomes conscious of the calories ingested. In the case of severely calorie restricted diets there is a huge loss of water and salt, leading to the false belief you will regain your svelte figure in no time.

The reason for this is that for the first time your insulin levels drop! High insulin levels as seen after consuming foods high in carbs, be it bread, pasta, rice, cereals, chips, crackers, ice cream or soft drinks, make your body retain salt and water.

My advice, therefore is, to first set a reasonable and realistic weight-loss goal, such as striving to lose 15 to 20 pounds rather than setting it to 50 pounds or more in the long term. Crash diets such as the 10 day green smoothie way are not sustainable and you set yourself up for failure and disappointment.

A lot of times all you have to do is cut out sugar laden soft drinks and snacking mindlessly throughout the day on chips, crackers or cookies. Eat two or three meals a day. Contrary to common wisdom, breakfast is not a must. Do not have second helpings even if you still feel hungry. It takes 20 minutes for fullness to set in. Remember, anytime you put sugars and carbs in your mouth, your insulin levels rise, preventing you from burning fat, which is the way to lose weight.

Another very important advice is to not eat or snack for at least 12 hours overnight! For example after finishing dinner at 6 or 7 pm, do not eat or drink anything but plain water until 6 or 7 am. No late evening or nighttime refrigerator raids.

A last word of advice, eliminate trips to fast food restaurants. Start cooking and eating most of your meals at home. If you need to lose 50 pounds or more you probably need to look into the Atkins Diet for Life for guidance, since it severely restricts carbohydrate consumption. Losing up to 20 pounds can easily be achieved and maintained with the Mediterranean diet which emphasizes a lot of legumes (beans and lentils), green leafy vegetables, nuts, lean meat and fish. Be sure to discuss any new diet with your doctor, especially if you have diabetes and take medications.

I have not mentioned exercise for one simple reason. By itself it will not yield a big weight loss. Simply hiring a trainer or taking out a gym membership without correcting your eating habits is doomed for failure. However, a regular exercise routine such a walking daily for 30 minutes will help you maintain your new weight.

To paraphrase a Chinese proverb A journey of a thousand miles begins with a single step or in the case of your selected diet with a single bite.

Dr. Eva Abbo is a doctor of internal medicine in La Jolla, Calif., and former Laurel resident.

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Jan 22

ReShape Lifesciences Inc. to Merge With Obalon Therapeutics, Inc. to Expand Weight Loss Product Offering – BioSpace

SAN CLEMENTE, CA / ACCESSWIRE / January 20, 2021 / ReShape Lifesciences Inc. (OTCQB:RSLS), a global weight-loss solutions leader, announced today that it has entered into a definitive merger agreement with Obalon Therapeutics, Inc., which is listed on the NASDAQ Capital Market, a company focused on developing and commercializing novel technologies for weight loss, under which ReShape and Obalon will combine in an all-stock transaction.

Under the terms of the merger agreement that has been unanimously approved by the boards of directors of both companies, existing ReShape stockholders will have majority ownership of the combined company immediately following the closing of the merger and Obalon will be renamed ReShape Lifesciences Inc. and will trade under the NASDAQ ticker symbol "RSLS." The current directors and officers of ReShape will comprise the board of directors and executive management of the combined company.

ReShape and Obalon have delivered some of the most innovative FDA-approved weight loss solutions for the treatment of obesity. According to a recent article in the New England Journal of Medicine, the past 50 years have seen increasing attention to the issue of obesity[1], citing the World Health Organization's current data showing that global prevalence of obesity has tripled since the mid-1970s with more than 1 billion adults being overweight in addition to 650 million adults and 124 million children and adolescents being obese. This has tremendous impact on health and health related costs globally as obesity is responsible for 41% of uterine cancers; more than 10% of gallbladder, kidney, liver, and colon cancers; 40% of cases of cardiovascular disease; and most cases of type 2 diabetes.2 Further relevant in today's world, SARS-CoV-2 infection (COVID-19) is more likely to cause serious illness or death in people with obesity than in those with a healthier body-mass index.3

Bart Bandy, President and Chief Executive Officer of ReShape commented, "We are excited with this opportunity to add Obalon's FDA approved Balloon System to ReShape's line of minimally invasive weight-loss solutions while also expanding our market reach. Our portfolio also includes the Lap-Band, emerging products that support bariatric surgical procedures across the spectrum and ReShapeCareTM, which is our reimbursed, telehealth-based patient support program that is available for any medically supervised weight loss program. This integration positions us to achieve our goals for growth and continued advancement towards becoming the premier weight loss company for physicians and patients."

Completion of the merger is subject to certain closing conditions, including, among other things, approval by the stockholders of ReShape and Obalon, the Securities and Exchange Commission declaring effective an Obalon registration statement registering the shares to be issued in connection to the merger, and the NASDAQ Stock Market's approval of the continued listing of the combined company in connection with the completion of the merger.

Maxim Group LLC is serving as financial advisor to ReShape in connection with the transaction and Fox Rothschild LLP is acting as its legal counsel.

1.Kumanyika S, Solving Population-wide Obesity, progress and future prospects. N Engl J Med 2020; 383:2198-2200

2. The GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017;377:13-27.

3. Yadav R, Aggarwal S, Singh A. SARS- CoV-2-host dynamics: increased risk of adverse outcomes of COVID-19 in obesity. Diabetes Metab Syndr 2020;14:1355-60.

About ReShape Lifesciences Inc.

ReShape Lifesciences is America's premier weight-loss solutions company, offering an integrated portfolio of proven products and services that manage and treat obesity and metabolic disease. The FDA-approved Lap-Band and associated program provide minimally invasive, long-term treatment of obesity and is an alternative to more invasive surgical stapling procedures such as the gastric bypass or sleeve gastrectomy. The ReShape Vest System is an investigational (outside the U.S.) minimally invasive, laparoscopically implanted medical device that wraps around the stomach, emulating the gastric volume reduction effect of conventional weight-loss surgery. It helps obese and morbidly obese patients with rapid weight loss without permanently changing patient anatomy. The recently launched ReShapeCare Virtual health coaching program is a virtual telehealth weight management program that supports lifestyle changes for all weight-loss patients, to help them keep the weight off over time.

Forward-Looking Statements

Certain statements either contained in or incorporated by reference into this document, other than purely historical information, including estimates, projections and statements relating to ReShape's business plans, objectives and expected operating results, and the assumptions upon which those statements are based, are "forward-looking statements." All statements, other than statements of historical facts, included in or incorporated by reference into this document regarding strategy, future operations, future financial position, future revenue, projected expenses, prospects, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to the structure, timing and completion of the proposed merger; the combined company's listing on the NASDAQ Stock Market after closing of the proposed merger; expectations regarding the capitalization, resources and ownership structure of the combined company; and the executive and board structure of the combined company. ReShape and/or Obalon may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Such statements are based on management's current expectations and involve risks and uncertainties. Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, risks and uncertainties associated with stockholder approval of and the ability to consummate the proposed merger through the process being conducted by ReShape and Obalon. ReShape disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances that exist after the date on which they were made.

Important Additional Information and Where to Find It

In connection with the proposed merger, Obalon plans to file with the U.S. Securities and Exchange Commission (SEC) a registration statement on Form S-4 that will include a joint proxy statement of ReShape and Obalon that also constitutes a prospectus of Obalon. ReShape and Obalon will make the joint proxy statement/prospectus available to their respective stockholders. Investors are urged to read the joint proxy statement/prospectus when it becomes available, because it will contain important information. The registration statement, definitive joint proxy statement/prospectus and other documents filed by ReShape and Obalon with the SEC will be available free of charge at the SEC's website (www.sec.gov) and from ReShape and Obalon. Requests for copies of the joint proxy statement/prospectus and other documents filed by ReShape with the SEC may be made by sending a written request to ReShape at 1001 Calle Amanecer, San Clemente, California 92673, Attention: Chief Financial Officer or to Obalon at 5421 Avenida Encinas, Suite F, Carlsbad, California 92008, Attention: Legal.

Participants in the Solicitation

ReShape, Obalon, their respective directors, executive officers and employees may be deemed to be participants in the solicitation of proxies from ReShape's and Obalon's stockholders in connection with the proposed transaction. Information about the directors and executive officers of ReShape is set forth in ReShape's annual report on Form 10-K for the fiscal year ended December 31, 2019, which was filed with the SEC on April 30, 2020 and its Form 3s and 4s filed on behalf of its directors and officers. Information regarding Obalon's directors and executive officers is contained in Obalon's annual report on Form 10-K and Form 10-K/A for the fiscal year ended December 31, 2020, which were filed with the SEC on February 27, 2020 and April 29, 2020, respectively, and its proxy statement for its 2020 annual meeting of stockholders, which was filed with the SEC on August 7, 2020. These documents can be obtained free of charge from the sources indicated above. Certain directors, executive officers and employees of ReShape and Obalon may have direct or indirect interest in the transaction due to securities holdings, vesting of equity awards and rights to severance payments. Additional information regarding the participants in the solicitation of ReShape and Obalon stockholders will be included in the joint proxy statement/prospectus.

ReShape Contact:Thomas StankovichChief Financial OfficerReShape Lifesciences Inc.949-276-6042tstankovich@ReShapeLifesci.com

ReShape Investor Contact:James SaliernoVice PresidentThe Ruth Group646-536-7028jsalierno@theruthgroup.com

SOURCE: ReShape Lifesciences Inc.

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Jan 22

Diet said to bust liver fat with plant goodness unveiled by Israeli academics – The Times of Israel

Israeli researchers say they have found a diet that significantly cuts liver fat, by tweaking the traditional Mediterranean regimen to include special greens.

Over 20 years our research team has shown through rigorous, randomized long-term trials, that the Mediterranean diet, rich with wholegrains, fruit, vegetables and nuts, is the healthiest, said epidemiologist Prof. Iris Shai. Now, we have found that specific changes to this diet can cause a big reduction in liver fat.

In an 18-month 294-participant study conducted in southern Israel, two-thirds of participants ate a Mediterranean diet, and exercised regularly. They lost weight in similar amounts, but those who ate the adapted green version, featuring less meat, more plant products, and lots of green tea, saw particular benefits in their liver.

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Even though the Mediterranean Diet and the Green Mediterranean Diet led to equal weight loss overall, fat loss in the liver was doubled among those who had the green diet, Shai told The Times of Israel.

Ingredients for a mediterranean diet (inaquim via iStock by Getty Images)

The liver is so important for general human health, and fatty liver disease has wide implications, but theres a lack of drug treatments and a lack of dietary protocol beyond general weight loss, which makes this finding important.

The modified diet aims for high levels of polyphenols, organic compounds produced by plants, seemingly to protect themselves from stress.

The study conducted by Shai, professor at Ben Gurion University of the Negev in Beersheba and an adjunct professor at the Harvard T.H. Chan School of Public Health, was recently published in the peer-reviewed journal Gut. Several Harvard scholars were involved in the study.

One of the items in the diet is an aquatic plant called mankai which an Israeli company, Hinoman, is marketing as a superfood. Shai is an advisor to the company.

An estimated 20 percent to 35% of adults have fatty liver disease, a condition which doctors say increases the risk of insulin resistance, type 2 diabetes, and cardiovascular conditions, as well as decreased gut microbiome diversity and microbial imbalance. But no drug is currently available and the only intervention is weight loss and curtailing of alcohol consumption.

Powdered form of the an aquatic plant mankai (Schachar Fleishman)

The diet is rich in vegetables, includes a daily intake of walnuts (28 grams), and less meat than a regular Mediterranean diet. It is enriched with green items including three to four cups of green tea per day and 100 grams of a mankai green shake.

Shai said: We believe there are components like polyphenols and fibers that modify the microbiome which make this diet help with cleaning fat from the liver.

Youre serious. We appreciate that!

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Thats why we come to work every day - to provide discerning readers like you with must-read coverage of Israel and the Jewish world.

So now we have a request. Unlike other news outlets, we havent put up a paywall. But as the journalism we do is costly, we invite readers for whom The Times of Israel has become important to help support our work by joining The Times of Israel Community.

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Jan 22

Everything You Need to Know About CBD for Weight Loss The Healthy – msnNOW

CBD Hemp And Medical Marijuana: What Do These Terms Actually Mean?

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It's no secret that marijuana not only makes you high, it can also bring on "the munchies." But what about cannabidiol or CBD? The marijuana derivative doesn't make you high and may have numerous health benefits. But does it make you reach for the potato chips and whatever else you can get your hands on to satisfy your suddenly surging appetite?

The answer may surprise you. "CBD suppresses the appetite," says Martin A. Lee, co-founder and director of Project CBD, a California nonprofit that promotes CBD research, and author of Smoke Signals: A Social History of MarijuanaMedical, Recreational, and Scientific. "It has the opposite effect of what's typically thought of with THC."

THC is delta-9-tetrahydrocannabinol, the compound in marijuana that's responsible for the high and the munchies. (CBD doesn't make you high).

Still, we're a long way from being able to say commercially available CBD products can help you control your weight or shed those extra pounds.

CBD is found in medical marijuana and is one of two main active ingredients in marijuana. The other is THC.

CBD can also be extracted from the hemp plant, a cousin of the marijuana plant which has much lower levels of THC. Farmers have been able to grow hemp since the 2008 Farm Bill was passed, but only as long as it has no more than 0.3 percent THC. (Here's more on the difference between CBD vs. THC.)

CBD's various health benefits (some scientifically validated, some not) have led to an explosion of CBD products. Among them: CBD oil, CBD tinctures, CBD capsules, and edible CBD. Oil can be ingested orally or vaped, but vaping has been linked to lung injuries, says the Centers for Disease Control and Prevention.

Learn more about the risks and benefits of vaping CBD.

One of the few studies done in humans reported that people who used marijuana regularly had a lower body mass index (BMI). The study stopped short of saying that cannabis actually caused a lower BMI or that CBD might have an effect.

Because scientists have not studied CBD extensively in humans, "most of what we have to go on is what CBD does to mice and rats," says Lee. And the research shows that CBD does indeed suppress rodent appetites.

To understand how CBD may affect hunger and your calorie burn, it's useful to know about the endocannabinoid system. This is a signaling network in your body that helps regulate metabolism and appetite.

There are two cannabinoid receptors: CB1 and CB2, which act as yin and yang.

"Generally speaking, CB1, if it's active, promotes food intake, promotes appetite, and enhances senses of smell and taste," explains Lee. CBD doesn't actually bind to this receptor but acts as a sort of "dimmer switch" turning down its effect on appetite. People who are obese have more appetite-friendly CB1 receptors.

CB2, on the other hand, acts as a brake on appetite and has been proposed as a drug target. Regular marijuana also seems to act as a brake on CB1, which could help account for the fact that regular users have a lower BMI, despite the munchies. Again, none of this suggests that currently available CBD products can help you slim down.

Research from 2012 found thatin obese mice with more of these receptorsmuting CB1 limited insulin resistance, which is a major factor in diabetes risk. A study published in 2016 in Diabetes Care found that CBD lowered blood sugar in people with type 2 diabetes. At least one company is investigating whether this is an avenue for drug development.

There are no formal guidelines on using CBD products and losing weight. That means there are also no recommendations on dosages or which kind of product might be best.

In general, CBD seems to be safe, says Bonni Goldstein, MD, medical director and owner of Cannacenters, a medical practice in Los Angeles and author of Cannabis is Medicine: How Medical Cannabis and CBD are Healing Everything from Anxiety to Chronic Pain. But there can be side effects like nausea, fatigue, irritability, and diarrhea. CBD can also interact with the blood thinner warfarin (Coumadin) and other medications.

"If you're a person who takes other medications, it's not a good idea to haphazardly add CBD thinking it will be completely benign," Dr. Goldstein warns.

Long-term use may also hurt your liver, according to the Food and Drug Administration (FDA).

This is not a simple question. While many states consider CBD legal, the federal government does not. California was the first to legalize medical marijuana. Now another 35 states, the District of Columbia, Guam, Puerto Rico, and the U.S. Virgin Islands have followed suit, according to the National Conference of State Legislatures.

National laws are another matter. The U.S. Drug Enforcement Administration considers marijuana and its components Schedule 1 substances, which are "drugs of abuse." There is a push to legalize marijuana at the national level. A bill to take marijuana off the Controlled Substances Act passed the House late in 2020 but has not yet reached the Senate.

The FDA has approved only one CBD-derived drug. That's Epidiolex, to treat rare forms of pediatric epilepsy.

With more than 42 percent of the U.S. population obese, the country is desperate for effective modes of losing weight. Right now, experts recommend diet and exercise above all. But for some people, it's hard to sustain lifestyle changes for long periods of time. Meanwhile, there are few drugs available to lower BMI.

The number of CBD products, including those that claim to lower weight, is exploding. So far, though, the evidence is far behind. "CBD is associated with decreasing appetite but I can't say it correlates to weight loss," says Lee.

The post Everything You Need to Know About CBD for Weight Loss appeared first on The Healthy.

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Jan 22

Types and stages of COPD: Symptoms, causes, and more – Medical News Today

The main types of chronic obstructive pulmonary disease (COPD) are emphysema and chronic bronchitis. They differ in the kind of damage they do to the airways and lungs. However, the causes, symptoms, and treatment of the two conditions are almost completely identical.

There are four stages of COPD that range from mild to very severe. A person with mild COPD may not know that they have the condition, while someone with very severe COPD will experience life threatening symptoms.

Keep reading to learn about the types and stages of COPD, including causes, symptoms, and treatment options.

COPD refers to a group of diseases that cause breathing problems and blockages in airflow. They gradually get worse over time. According to the Centers for Disease Control and Prevention (CDC), nearly 15.7 million people in the United States have a diagnosis of COPD.

The CDC add that COPD is more common in:

A persons windpipe connects to the lungs, where it divides into many smaller branches. These branches end in small air sacs called alveoli, which have tiny blood vessels known as capillaries running along their walls. Here, oxygen passes from the sacs into the capillaries, and the waste product carbon dioxide passes from the capillaries into the sacs. Breathing involves this exchange of gases.

In someone with healthy lungs, the airways and air sacs are stretchy. This elasticity permits the sacs to inflate when a person breathes in and deflate when they breathe out.

People with COPD have less air going in and out of their airways because of one or more of the following:

The two main types of COPD are emphysema and chronic bronchitis, but many individuals with COPD can have both.

In emphysema, the alveoli, which are the walls of the air sacs, and the small airways suffer damage. As a result of this damage, the sacs lose their shape and ability to recoil during the expiratory phase of the breathing cycle, resulting in trapped air in the lung. This trapped air continues to distend the alveoli, causing a repeating cycle of airway obstruction.

These changes eventually result in the lungs becoming hyperinflated, which reduces the exchange of gases. This makes it difficult for people to breathe and oxygenate their blood effectively while impairing the ability to breathe out carbon dioxide from the blood.

In chronic bronchitis, the lining of the airways stays inflamed. This leads to swelling and the formation of large amounts of mucus. These effects make it hard to breathe.

Learn more about the differences between emphysema and chronic bronchitis here.

Below we describe the stages of COPD.

There are multiple classification systems used in diagnosing COPD conditions. The following stages come from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, which derive from a specific breathing test called spirometry grading.

However, this type of testing only captures one component of COPD severity. For example, two patients with the same result may have different tolerances to exercise, symptoms, and prognoses.

Therefore, other COPD aspects, such as the severity of symptoms, risk of exacerbations, and presence of comorbidities, are important to the patients experience of the disease and prognosis.

According to the National Heart, Lung, and Blood Institute (NHLBI), the leading cause of emphysema and chronic bronchitis involves long-term exposure to substances that irritate the airways and lungs. The NHLBI note that the primary sources of irritants include tobacco smoke from:

The following irritants can also play a role in the development of COPD:

In addition, a genetic condition called alpha-1 antitrypsin deficiency may play a role in developing emphysema. It involves reduced production of a protein that protects the lungs.

Symptoms of emphysema or chronic bronchitis include:

Aside from the above, some people may have frequent colds and flu.

If COPD is severe, symptoms may include:

While emphysema and chronic bronchitis have no cure, lifestyle changes and medical treatments can help a person feel better and delay the worsening of conditions.

Medications can include bronchodilator inhalers, which relax the muscles surrounding the airways, making it easier to breathe. Below, the NHLBI note the type of inhalers appropriate for different stages:

Because respiratory infections can cause serious problems for individuals with COPD, doctors may recommend getting vaccines to reduce their risk. These include the flu and pneumonia vaccines.

Oxygen therapy can help people with severe COPD, accord to the NHLBI. A person on this treatment receives the oxygen through a mask or nasal prongs. The NHLBI list the following benefits from this treatment:

A lung transplant is a last resort for people with one of the main types of COPD. If a person has emphysema, they have other surgical options, including:

Quitting smoking is the most important thing someone with COPD can do. If individuals find this challenging, they may wish to join a support group.

They may also consider asking their family and friends for additional support. It is also helpful for them to avoid secondhand smoke and other irritants in their environment.

People with COPD may have difficulties in eating enough because of their symptoms. If so, they can talk with their doctor about recommendations to help them get enough nutrition. For example, a healthcare professional may advise eating smaller, more frequent meals.

Another lifestyle-related measure involves attending pulmonary rehabilitation, a personalized program that teaches management strategies. The plan may include instruction in breathing techniques and ways to conserve energy.

The two primary types of COPD are emphysema and chronic bronchitis.

The four stages of COPD range from mild to very severe. Some symptoms may include an ongoing cough, shortness of breath, and wheezing.

A primary cause of both COPD types is long-term exposure to tobacco smoke, so doctors strongly urge people with the conditions to stop smoking.

In addition to this, lifestyle changes, such as quitting smoking, or treatments, such as medications and oxygen therapy, can also help.

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Jan 22

How the Internet Sent GameStop Stock Up 1,000% And Where It’s Going Next – InvestorPlace

In December, I wrote an article suggesting investors write covered calls on GameStop (NYSE:GME): buy GME stock and profit from the fat premiums on call options. Its a conservative tech investors way of making money on a stock thats too hot to buy, but too strong to ignore.

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Investors following that strategy would have seen a 25% gain in three weeks not bad for an options strategy with capped upside. But with shares now up 1,000% since last year, people are starting to ask themselves: How did we get here in the first place? The answer is a complicated mix of finance, momentum and a virtual game of chicken. So, heres how we got to where we are, and where GME stock might head next.

In a year where both Microsofts (NASDAQ:MSFT) Xbox and Sonys (NYSE:SNE) PlayStation finally released digital-only versions of their consoles, you might think that GameStop stock investors would have panicked. For years, the company had resisted calls to modernize. Instead, the brick-and-mortar relic stayed alive thanks to its cash cow: the lucrative used-game market. And now that many next-generation game consoles will no longer need physical games, GME stock looked set to fall.

GameStop shares, however, did precisely the opposite of what you might expect. Proving that no amount of wisdom can predict the madness of crowds (or internet users), shares rose 150% by the time I suggested taking gains off the table. Since then, the stock has proceeded to triple.

Long-term investors with a sense of humor might remember the Financial Times suggesting that the then-dying RadioShack could start selling fruit baskets or turning stores into Zumba studios to survive.(A small town in Weaverville, CA seems to have done just that.) Thats because, in the world of brick-and-mortar retail, those that dont adapt end up like Blockbuster and Circuit City sitting in bankruptcy court and explaining lawyer fees to angry investors.

For years, GameStop seemed destined for the same scrapheap. Though management successfully lobbied Microsoftin 2013 to keep disc drives in the Xbox One, they failed to use that lifeline to migrate toward online and mobile games.

But dont discount the short-term.

The release of the blockbuster PlayStation 5 and Xbox Series X threw Wall Streets tea leaves into disarray. With both consoles selling out within minutes, analysts scrambled to revise GameStops estimates for the near term. Wall Street now expects sales to rise 4.5% this quarter, representing a reversal after years of decline. And bullish retail investors went wild, sending the stock from the $4 range to $14.

But retail investors werent done quite yet. By December, a strange phenomenon started to appear: Open interest in GME calls had reached unprecedented levels as online investors egged each other on. In other words, investors were not only betting GME stock would go up but also that gains would come sooner rather than later. And whenever this happens, investors can inadvertently start a feedback loop. Thats because buying call options en-masse also force market makers to buy the underlying security in this case, GME shares. Its a process known as delta hedging, where market makers like the New York Stock Exchange look to keep a neutral position.

Meanwhile, rising share prices force short sellers out of their positions, causing them to become buyers in whats known as a short squeeze. That forces up shares even further, causing even more online users to (self-reportedly) buy in, and so on. Eventually, the companys shares end up as a caricature of its intended price.

And how long can the mania go? A) If someones had the misfortune of going short, the feedback loop will usually continue just long enough to force them out of their position at a loss. B) If theyre long, the loop will last just long enough to when theyve convinced themselves that the stock is a long-term winner. And C) if they dont own the stock and decide to buy in, thats usually the precise moment that the bottom falls out.

Its not the first time a brick-and-mortar store caused such an investor frenzy. Almost a decade ago, GNC found itself in the eye of the protein-supplement storm. What was once the purview of bodybuilders suddenly saw its 15-minutes of fame. Pantries across the U.S. stocked up on the protein miracle cure for everything from weight loss to muscle building, and GNCs stock rose from $15 in 2012 to almost $60 by the end of 2013.

Back then, however, options trading was far more limited. Robinhood was only just getting started, and most retail investors didnt have the tools needed to send market makers and short sellers into an upward-spiraling feedback loop. Even as bearish short interest in GNC stock mounted, short squeezes rarely amounted to more than 20% price jumps.

GameStop, on the other hand, makes GNC look like childs play. Today, GameStop has a 109% short interest ratio, meaning there are more shares sold short than exist.

And GMEs open interest of nearly 850,000 options is seven times greater than Best Buys (NYSE:BBY) 115,000, even though GME is less than a tenth of the latter companys size. While Citron Researchs $20 price target for GameStop could be right, theres nothing that can stop retail investors pushing GME to $60 and beyond in the short term. There simply arent enough shares to sell short.

Its impossible to know how far GME can rise from here. The company now trades for 373 times its Shiller price-to-earnings (P/E) ratio, a measure of long-term value. Today, shares are looking less like Best Buys steady-state 36x multiple and more like Amazons (NASDAQ:AMZN) high-growth 355x.

So, when your companys share value isnt attached to real life, whats to stop it from rising to 600 times or more? The 17th-century Dutch-tulip-bulb mania offers a sobering reminder of humanitys ability to ignore reality. At their peak, the most expensive bulbs could cost more than a house.

Those insisting to profit from GME should consider selling options and hedging with a position in the underlying security much like what professional market makers do. With implied volatility close to 180%, GME options are selling for fat margins; at-the-money 2022 calls cost almost $16.

But dont go naked short or long GameStop and expect easy wins. As we collectively stumble through 2021, it would be wise to remember this: GME stock could continue a run to $60 and beyond if the short squeeze (and internet cheerleaders) continue their gleeful mischief.

But unless GameStop management uses the momentum to revamp its business, it would all be for nothing. Because, as hundreds of defunct brick-and-mortar companies can attest, if you wont stop yourself from pursuing an outdated business model, then a bankruptcy court will eventually do it for you.

On the date of publication, Tom Yeung did not have (either directly or indirectly) any positions in the securities mentioned in this article.

Tom Yeung, CFA, is a registered investment advisor on a mission to bring simplicity to the world of investing.

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How the Internet Sent GameStop Stock Up 1,000% And Where It's Going Next - InvestorPlace

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Jan 22

Turns Out, Your Cat Has a Pretty Good Reason For Knocking Things Over! – POPSUGAR

Chasing their owner's feet, attempting to eat tape, and scratching mirrors cats have a long list of quirky behaviors that leave us puzzled! One cat habit I really can't seem to figure out, though, is why they love to knock things over. Why do they seem to find enjoyment in pushing items to the edge of the table and watching them fall as their owner (aka me) looks on in frustration? What gives!? As two experts explain below, this behavior is common in felines and has some pretty interesting motives behind it.

Cats knocking things over is nothing out of the ordinary, and as it turns out, there are a few good reasons cats may act out this (sometimes infuriating) behavior. One of the reasons, according to Maureen Murithi, DVM, registered veterinarian and veterinary spokesperson of online pet resource SpiritDog Training, is that cats are natural hunters and their desire to knock things over may be rooted in prey drive. "They normally use their paws to test unfamiliar objects in their environment," Dr. Murithi said. "Cats' paws are highly sensitive, and therefore they use them to test if unfamiliar objects are safe."

Another motivation cats may have to knock things over is they are trying to get their owner's attention. Ever set down a glass of water on the table and walk away, only to have your cat push it to the edge and knock it over? Yup, it may be because they are trying to catch your eye. "Cats love attention and are keen to notice your reaction depending on their behavior," Dr. Murithi told POPSUGAR. "Your reaction following an accident around the home, such as knocking over a flower vase, can condition them to associate it with attention." So it is important to act nonchalant when these situations come up.

Last, but not least, cats may be knocking things over around the house because they are curious and, quite simply, bored. "Cats are very curious," said Jeff Werber, DVM, chief veterinary officer for Airvet. "Their natural inclination is to touch things, which becomes a problem if what they are touching is not well-anchored." Dr. Werber cautioned that if your cat is knocking things over continuously, they may be bored.

Because indoor cats are kept inside and not able to go out and fulfill their innate curiosity with outdoor stimuli, Dr. Murithi advised to schedule a play time with moving objects to help remedy any boredom or desire to be entertained associated with knocking things over. "To avoid such accidents, scheduled playtime is advised, aimed at finding a release from pent-up energy," Dr. Murithi said. "Moving objects offer a nice distraction, especially for indoor cats as they lack the freedom to explore the outdoors and exercise or play."

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Turns Out, Your Cat Has a Pretty Good Reason For Knocking Things Over! - POPSUGAR

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Jan 22

The 3 Hormones This Longevity Expert Wants You To Focus On For Healthy Aging – mindbodygreen.com

Testosterone is also crucial for building muscle, says Blander. "It's an anabolic hormone," he notes, which means it stimulates muscle growth. Plus, when it's low, it's linked to a plethora of age-related concerns: According to one study, testosterone insufficiency in older men is associated with increased risk of death from heart disease. "There is also a strong correlation between levels of testosterone and age [itself]," Blander adds. "Every male, every year, loses between 1 and 2% of his testosterone levels during his life span. So if your testosterone stays higher, you are theoretically younger compared to your peers."

Admittedly, much of the research on low testosterone has been done on men (women have naturally lower levels of the hormone already, and doctors don't always have the same treatments for insufficient levels). But according to Blander, testosterone is importantfor both genderswhen it comes to its ratio with cortisol. (Again, cortisol can break down muscles.) "We need to find a way to make testosterone the highest possible, naturally, and then make the cortisol the lowest possible. Then you have a better way to build muscle."(Pro tip: A nutrient-dense diet rich in healthy fatslike a ketogenic dietcan help optimize testosterone levels.)

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The 3 Hormones This Longevity Expert Wants You To Focus On For Healthy Aging - mindbodygreen.com

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