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Think you burn most of your calories through exercise? Think again.

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If your weight is on your mind, you're probably overwhelmed with calories from checking food labels for them to counting them to figuring out how many you need to stick to in order to see the numbers on the scale budge.

And while the weight-loss concept of burning more calories than you take in each day sounds simple enough, calories are still fairly misunderstood by the average person.

Below, we clear up five common misconceptions.

Myth 1: A Calorie Is a Calorie

A 50-calorie apple behaves the same way in the body as a 50-calorie candy bar, right? Not exactly.

The idea that "a calorie is a calorie is a calorie" doesn't capture the whole picture. According to the U.S. Department of Agriculture, one calorie equals the amount of heat required to raise the temperature of one kilogram of water one degree Celsius. Going strictly off that definition, calories are the same, but you also have to factor in the quality of the calories if you're thinking about how the food will affect your metabolism and overall health.

The most-often-cited research supporting this idea comes from a July 2007 study published in Obesity that was conducted on monkeys rather than humans. It found that monkeys that consumed trans fats gained four times more weight than monkeys that did not, despite consuming the same number of calories.

"Macronutrients and micronutrients matter with everything you eat," says Deena Adimoolam, MD, an endocrinologist and assistant professor of medicine, endocrinology, diabetes and bone disease at Mount Sinai Morningside.

That's because certain nutrients signal different things to the body. For instance, refined grains and starches are less satisfying than less-processed, higher-fiber foods and can increase hunger and calorie intake later as a result, according to a December 2011 study in The New England Journal of Medicine.

So even though the calories in an apple and a small candy bar might be equal, the foods aren't treated equally in the body.

"The components that make up the calories are sometimes more important than the calories itself," says Bansari Acharya, RDN, a registered dietitian and nutritionist.

Most of the calories in the candy bar come from added sugars, she explains. The apple, on the other hand, is part of a nutrient-rich package that comes with fiber, vitamins, minerals and phytochemicals, which may fight cancer and heart disease, according to Harvard Health Publishing.

Myth 2: You Burn Most of Your Calories Through Exercise

Going on a 30-minute run in the morning may be the most physically taxing part of your day, so you probably think that's when you burn the majority of your calories. Not so.

You actually burn the most calories over the course of the day while you're at rest whether you're sleeping, working or sitting down for a meal. That's because the body requires a significant number of calories just to keep up with its basic functions, such as breathing, digesting and circulating blood, according to the National Academy of Sports Medicine (NASM).

This is called your resting metabolic rate (RMR). There are several factors that determine your RMR, such as genetics, age, weight and height, according to the American Council on Exercise (ACE).

There are also a couple of ways to calculate your RMR, but a 38-year-old woman who weighs 145 pounds can expect to burn approximately 1,400 calories per day outside of exercise, according to the NASM.

As for that morning run? It's still a good practice, since exercise offers a host of benefits and can keep the body burning extra calories even after cool down (a phenomenon known as excess post-exercise oxygen consumption, or EPOC), according to the ACE.

Just be realistic about how many calories you're burning during the workout. For a 155-pound person, running 3 miles at a 9-minute pace burns about 400 calories, according to Harvard Health Publishing.

Myth 3: Some Foods Have 'Negative Calories'

The idea here is that the body uses more calories to eat and digest certain foods than the foods themselves contain, leading to a calorie deficit, or a "negative-calorie food."

Unfortunately, there's no science to prove that a food actually leads to a net loss in calories, according to the Mayo Clinic. Plus, quite simply: "Every piece of food has some calorie value," Dr. Adimoolam says.

That said, it's still a good idea to load your plate with these so-called 'negative-calorie foods' since they tend to be fruits and vegetables that are part of a healthy diet anyway (think: celery, lettuce and cucumbers).

Myth 4: Burning or Cutting 3,500 Calories Makes You Lose a Pound of Fat

You may have heard that 3,500 calories equals a pound of fat an idea that can be traced back to research from the 1950s, according to a July 2014 review in the Journal of the Academy of Nutrition and Dietetics. It's a nice and simple equation, but it doesn't quite hold up.

"This is a rule of thumb that is way overgeneralized," Acharya says. "The amount it takes for a person to lose 1 pound of fat depends upon a myriad of factors, including the person's gender, activity level, lifestyle choices and changes and current diet plan."

Additionally, "everyone has a different metabolism, and everyone has a different body composition of fat versus muscle, aka lean body mass, and these factors are just a few which help determine how quickly one will lose fat," Dr. Adimoolam says.

There's also no way to target fat cells specifically when losing weight. According to the researchers behind the July 2014 review, the first phase of weight loss mainly pulls from the body's carbohydrate and protein pool, while during the second phase, which could last for months or even years, the body turns to fat.

Another issue is that, as body mass decreases, metabolism changes and the body ends up burning fewer calories at rest.

"As you start to lose weight, your body needs fewer calories and your calorie deficit will get smaller as you continue to lose weight," Acharya says. "Many people don't factor this in when they are following a generalized 'rule' and experience disappointment when they see they are not losing weight as fast as they did in the beginning."

Myth #5: Counting Calories Is the Best Way to Lose Weight

A tried-and-true weight loss tactic is to count calories and ensure you don't exceed your calorie limit at the end of the day. There's certainly some truth here both Acharya and Dr. Adimoolam agree calorie counting can be an effective way to lose weight.

But it's not the only way. A February 2018 JAMA study suggested that being beholden to nutritional fact labels and meticulously tracking every last calorie may not be necessary for weight loss.

The study found that people who followed a simple prescription for healthy eating maximize vegetable intake, focus on whole foods and cut back on refined flours, trans fats and added sugar for one year resulted in a significant amount of weight loss without ever tracking calories. The researchers looked at people who followed a low-fat diet versus a low-carb diet and found this approach worked for both groups.

What matters more is that you take an individualized approach to weight loss and consider your needs and what will work best for you, Acharya says.

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5 Myths About Calories That Could Prevent You From Losing Weight - LIVESTRONG.COM

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Remember when snacking was reaching into your office desk drawer for that bag of almonds? Or noshing on an apple after you got back from yoga class before you headed to the library to pick up your holds? Nowadays, as we all spend endless minutes, hours, weeks, months, or our lives at home, the world of snacking has become a bit too accessible for comfortall we have to do is walk a few strides into our kitchen and look around. Or observe our waistlines.

Its no surprise many of us have putsome extra weight while staying mostly indoors.But heres the good news: Good-for-you snacking doesnt have to be bland, and there are countless exciting options to boost your snacking game with hardly any grunt work. Below, we tapped RDs for their favorite waistline-friendly snacks. Snack oclock has never looked better. (Looking for more healthy eating inspiration? Check out these six vegan dessert recipes for weight lossand the best plant-based breakfast recipes for weight loss.

How to make it: Drain and rinse a 15-ounce can of chickpeas. In a food processor, combine chickpeas, one cup rolled oats, -cup all-natural smooth peanut butter, -cup maple syrup or agave syrup (Gentile recommends honey if youre not strictly vegan), and one teaspoon vanilla extract. Blend until almost smooth. Then, remove, mix in -cup mini chocolate chips and shape into two-inch balls.

Why it helps with weight loss: Theres good reason this is Gentiles favorite filling snack that doesnt make the scale tip upwards. The fiber in the chickpeas and oats provide a slow rise in blood sugar levels, along with keeping you feeling full. The protein in the peanut butter keeps you feeling satisfied thanks to preventing swings in blood sugar, says Gentile. Worth keeping in mind: To ward off mindless munching or overeating at the next meal when you're trying to lose weight, it's important not to go too long in between meals, adds Gentile.

How to make it: Mix one can each of drained and rinsed corn and black beans, then add two seeded and chopped red bell peppers, half a chopped red onion, one diced avocado, and the juice of a whole lime. Add salt and pepper to taste. For extra heat, you can also add a chopped and seeded jalapeo pepper. Mix gently to combine. Have about a cup with six or seven large tortilla chips per serving.

Why it helps with weight loss: This is a fantastic snack because it provides great satiety. The beans and vegetables have filling fiber and the avocado is full of monounsaturated fat which is good for your heart but also keeps you feeling full, offers Hauser.In lieu of tortilla chips, have it with jicama sticks for a refreshing taste that still delivers a satisfying crunch.

How to make it: Preheat the oven to 350F. Peel four very ripe bananas and mash in a large mixing bowl until smooth with a potato masher or fork. Add three cups of old fashioned or quick oats (not instant), -cup of your favorite nut butter like peanut butter or sunflower butter, one teaspoon of ground cinnamon, and one teaspoon of pure vanilla extract. Mix well with a spatula until well combined, and let sit for about 10 minutes so the oats can soak in the moisture. Scoop the mixture into two tablespoon-sized scoops and place onto a baking sheet lined with parchment paper and bake for 12-to-14 minutes. Note: These cookies keep well at room temperature for one-to-two days in an airtight container. After two days, put them in the refrigerator and finish in a few days.The serving size for this recipe is two cookies.

Why it helps with weight loss: My favorite vegan homemade snack for weight loss is what is often called a breakfast cookie. It's a cookie made of oats, bananas, and nut butter. It's a great snack for weight loss (and everyone) because it is balanced, meaning it has all three macronutrients of carbohydrates, protein, and healthy fat. This balance helps with satiety, says Hauser. They're sweet enough on their own to make you feel like you're having a treat, she adds, noting that you can also place additional mix-ins like a -cup of dried fruit such as raisins or unsweetened dried cranberries, seeds or chopped nuts, or dairy-free mini chocolate chips.

How to make it: We werent lying when we said these recipes were easy: Spread peanut butter on a slice of whole-wheat bread. Cut bread into four to enjoy bite-sized treats. Sprinkle cinnamon, turmeric, or ginger on top if desired.

Why it helps with weight loss: This idea provides fiber, protein, and heart-healthy fat to help you stay full while trying to lose weight, says Banna. It's important to focus on foods that provide a sense of satisfaction and don't have a lot of empty calories to

leave you hungry again quickly. If you prefer almond butter to peanut butter, go ahead and substitute it.

How to make it: Drain and rinse two cans of chickpeas. Dice half a red onion, a celerity stick and two sheets (or desired amount) of seaweed. Lightly run chickpeas through the food processor until slightly chunky consistency or mash with a fork. You can also place in a blender for two-to-three pulses. Add two tablespoons of lemon juice and mix to combine. Place all ingredients in a bowl, add two tablespoons of lemon juice and mix to combine. Add in two tablespoons of Tahini at a time and mix until you reach your preferred consistency. Note: This makes four servings.

Why it helps with weight loss: A savory salad that will fast become your go-to. This recipe makes a great option for a low-fat and low-carbohydrate snack.The protein and fiber in this recipe will keep you feeling full for longer, which will help prevent overeating, says Best. It can easily be paired with celery or carrots to amp up the nutrients without adding refined carbs through chips or bread.

How to make it: In a blender, blend three blanched and peeled tomatoes, habanero pepper, onion, and two cloves garlic until chunky smooth consistency forms. Add in cup cilantro, chopped, teaspoon cumin, teaspoon oregano, salt to taste, and lime juice on top. Serve with some cut up bell pepper strips of any color for dipping into salsa. Note: This makes two servings.

Why it helps with weight loss: This snack is the perfect snack for individuals wanting to lose weight! It is less than 100 calories total, however, filled with tons of vitamins and minerals. It is also completely fat-free and low-calorie so one can eat it in large portions without feeling guilty, shares Acharya. Due to its high fiber content, this snack also will keep you feeling fuller for longer without the calories or heaviness. Pro tip: Swap in radishes, carrots, cucumbers, or another crispy veggie instead of bell peppers to mix things up.

Read the original:
The 6 Best Snacks for Weight Loss, According to Nutritionists - The Beet

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If you're hoping to drop a dress size and you've done your research, chances are you'll have come across the Atkins diet. First promoted in the 1960s by cardiologist Robert C Atkins, the Atkins diet involves ditching carbs in favour of protein and fats to facilitate rapid weight loss.

As a restrictive diet it has received some criticism with experts warning it is unsustainable and may be dangerous if used as a long-term fix, but several studies have also found that the Atkins diet improves blood sugar control and lowers cholesterol, so the jury is currently out.

We speak to dietitian and nutritionist Susie Burrell about what the Atkins diet is, how it works to help you lose weight and the potential risks:

The Atkins diet is a low-carbohydrate, high-protein diet designed for dramatic weight loss. The eating plan involves four different phases: induction, balancing, fine-tuning and maintenance.

Most people follow the Atkins diet to lose weight. However, the diet is also promoted as a lifelong approach to eating that may help maintain weight loss, boost energy levels and reduce the risk of some health problems, such as high cholesterol and high blood pressure.

In recent years, the ketogenic diet, or keto diet, has gained popularity. Both keto and Atkins are low-carb diets and may be used for weight loss, blood sugar control and heart health. However, there are two key differences between the two diets:

the keto diet is made up of 70 to 80 per cent fat, making it lower in protein than the Atkins diet.

On the Atkins diet, you slowly increase your carb intake, unlike the keto diet, which remains very low carb to keep your body in a state of ketosis so that it burns ketones for energy.

The Atkins diet is split into four different phases to help you reintroduce carbohydrates until you find the right carb balance that allows you to maintain your ideal weight.

However, this approach is not compulsory and depending on your goals, you may start at any of the first three phases. Below is a guide to the four phases:.

The Atkins diet menu varies depending on which phase of the diet you are in. However, the following foods are generally allowed:

Anna KurzaevaGetty Images

According to the Atkins diet, the following foods should generally be avoided:

A typical day on the Atkins diet during Phase 1 may look like this:

You can find more meal plans here.

Burrell recommends the Atkins diet for people who have large amounts of weight to lose and are happy to stick to a strict diet at the beginning to kickstart their weight loss.

The best aspect of the Atkins diet is that it will help you drop a few kilos quickly which can be motivating, Burrell explains. But long term, it is unlikely to be a sustainable diet.

The Atkins diet will help you drop a few kilos quickly but long term, it is unlikely to be a sustainable diet.

Burrell also cautions that like most diets, Atkins is not for everyone. Low carb also does not always work for active people who do not have much weight to lose, or for those with glucose regulation issues including insulin resistance. Here, we often see plateaus quickly on a low carb approach.

You can drink alcohol on the Atkins diet, however, it is not recommended for Phase 1. From Phase 2 onwards, you can drink moderate amounts of low-carb alcoholic drinks, such as wine and some spirits (gin, vodka and whisky with diet mixers is recommended).

However, it is important to remember that alcohol slows down weight loss by slowing your metabolism so, if weight loss is your goal, you may decide to limit alcohol completely.

It is possible to follow the Atkins diet if you are vegan or vegetarian. However, you should start in Phase 2, and include protein such as eggs, cheese and soy products, such as tofu. Vegans may include seeds, nuts, soy products, high protein grains and legumes.

The Atkins diet is generally regarded as safe for most people. However, it is not appropriate for everyone and if you are concerned, it is always best to check with your doctor first.

The following people should not start the Atkins diet without seeking medical advice first:

In addition, Burrell warns that there are a number of side-effects you may experience in the initial stages of the diet, such as headaches, weakness and constipation.

The first few days can be tough for big eaters as their body adjusts to having far less glucose from carbs around, she explains, adding that people with glucose issues may need to have their medication adjusted once they have significantly reduced their carb intake.

Like most low carb diets, you will probably lose weight on the Atkins diet. However, studies show that low carb diets such as the Atkins diet are no more effective than other calorie-restricted diets, and most people eventually put the weight back on.

Any diet works when it is followed, the issue is that strict low carb diets are rarely followed long term and most of the time weight loss is regained,' adds Burrell.

So in conclusion, if followed correctly the Atkins diet can be an effective way to lose weight quickly but keeping the weight off long-term may be the real challenge. If youre serious about making positive lifestyle changes, research has shown that long term weight loss is more successful when diet and exercise are both implemented.

If you have any concerns about your health, get the go-ahead from your doctor before starting a new diet or healthy eating plan.

Last updated: 09-11-2020

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Is the Atkins diet the solution to rapid weight loss? - Netdoctor

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The holiday season is quickly approaching, and among with it comes more opportunity for gatherings centered around food and sweets. Regardless of whats being celebrated, eating during the holidays typically consists of family recipes and delicious desserts. Because of this, food can become a major source of anxiety for anyone trying to diet or even just maintain their current health goals.

Concern and stress regarding holiday food can lead some to completely concede their health goals -- swearing to themselves that when the first of the year rolls around theyll change their ways for good. But contrary to popular belief, you can still participate in all your favorite holiday traditions and foods without compromising your progress or goals.

Concern and stress regarding holiday food can lead to destructive comments like, Ill just not eat today so I can save up for an extra plate/dessert tonight, or Ill need to run this off later or Ill gain weight or I cant be trusted around this food, Ill eat the whole dish.

Most of us have heard or even said a variation of one of these phrases before. They sound innocent enough, but upon further inspection they all promote a restrictive mindset toward food.

Restricting yourself with food can be unintentional, hiding in the name of discipline. You might think that by holding back and not eating your favorite things youre being strong and controlled, not letting the holidays be a reason to break your diet. By holding yourself back from enjoying your favorites, you could be feeding into diet culture and end up doing more harm than good in the long run.

What is diet culture? It's a belief system that focuses on and values weight, shape and size over well-being. More often than not, toxic diet culture promotes an unhealthy pattern of eating with a sole focus on being skinny.

Diet culture can be a weapon, rendering those who fall victim to it to believe theyre not supposed to eat foods that aren't labeled good. It promotes an unhealthy idea of discipline and dieting thats unsustainable to follow for long periods of time, and leaves the person feeling guilty and unworthy of eating certain foods.

Labeling certain foods such as cookies, cake, pie, etc., bad is a move that traditional diet culture profits off immensely. Doing so can unintentionally lead you to subconsciously glorify these foods. If you hold yourself back from enjoying them, its more likely youll trick your mind into wanting the food more. At the worst level, this could lead into a permanent unhealthy relationship with food and diet culture.

So what does this mean you should do for the holiday if you have a goal of weight loss, but your most treasured part of the holiday season is enjoying the familiar flavors of a home-cooked meal? In short, enjoy your meal. Being a healthy person requires a delicate balance, and it is certainly attainable to eat a meal you mightve once considered bad and still lose weight.

Remember that while holidays like Thanksgiving and Christmas are centered around eating a huge meal, lots of options are still bound to be healthy. Corn, turkey, green beans, potatoes, etc., are all traditional Thanksgiving foods that might even be healthier than a typical dinner.

Ultimately, whatever your holiday food is going to consist of depends solely on your personal goals and your relationship with food. The most imperative thing is to be in touch with your personal goals and what you want out of the holiday.

If you have a goal to lose weight, thats totally achievable even while enjoying yourself and treating yourself. Instead of punishing yourself the next day and attempting to burn off all the food you ate, simply treat the next day as you would any other day.

If youre not comfortable setting aside your usual dietary patterns for a celebration, or you know its impossible for you to eat certain foods without feeling guilty, thats okay too. If this is the case, it would be beneficial to talk to whoever youre celebrating with to make sure they know how much you value sticking to a certain diet. Portion control is key.

Its important to remember that just as one healthy meal wont make you skinny, one holiday dinner or dessert wont blow your diet or slow your progress. Its normal to fall off routine during the holidays, so dont beat yourself up for it.

Avoiding that all-or-nothing mindset is whats going to help keep you on track and get right back to your healthy habits when the holidays are over.

@BussertMaddie

mb901017@ohio.edu

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How to prioritize your health over the holidays without restricting, missing out - The Post

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Banana chips can offer potassium and fibre

Banana chips are surely delightful. They are made by deep frying ripe banana slices in coconut oil or mustard oil. You can season them with salt, red chilli powder and even some sugar to get the desired taste. Homemade banana chips, when cooked in a healthy way, can make for a healthy snacking option. This crispy snack can provide you with potassium, a mineral which is great for blood pressure control. Banana is also rich in fibre, a nutrient that can help you have a healthy digestive system and prevent constipation.

Healthy snacking can help you lose weight effectively. What you eat in-between meals affects your main meals, hunger, calorie intake and how quickly you can achieve your weight loss goals. Eating a nourishing snack which is rich in protein, fibre or healthy carbs can help you stay energetic throughout the day and with time, reduce your appetite.

Also read:Is It Healthy To Eat Bananas With Milk? Here's The Answer From Our Expert

A lot of healthy and nourishing snacks can be prepared at home and stored for a long period of time. Ghee-roasted makhana, roasted black chana, roasted nuts, nuts and seeds trail mix, seasoned puffed rice and seasoned flattened rice are a few healthy snacking options that you can have.

Ghee roasted makhana make for a healthy snacking optionPhoto Credit: iStock

Speaking of banana chips, they too can be a healthy snacking option, however, the same is widely dependent on how you cook them. We speak to nutritionist Nmami Agarwal if banana chips are really a healthy snacking option.

Also read:Holiday Weight: Practice Portion Control, Snack Healthy And Other Tips That Can Help

"The nutritive value of banana chips depends a lot on the method of cooking. If they are deep-fried, it may put an extra load of calories that may surpass the nutritional value of both banana and coconut oil. However, if banana chips are baked or prepared using an air-fryer, with minimal oil- they can be enjoyed sometimes as a part of a healthy diet," she tells DoctorNDTV.

She goes on to add that banana chips can also be baked with some herbs and spices. It can further enhance the flavour and the nutritive value of this delicious sack. "The best way to enjoy your banana chips is to prepare them at home so that you can keep a check on ingredients. Packaged banana chips may have the addition of sugar or usage of sub-standard cooking oil," she informs.

Also read:6 Fibre-Rich Snacks That Can Help You With Weight Loss And Better Digestion

It is also important to note that banana chips are going to have significantly lesser potassium than a whole banana fruit, and more saturated fat. "So make sure to add whole banana fruit in your diet and not just in the form of chips," Agarwal adds.

(Nmami Agarwal is nutritionist at Nmami Life)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Weight Loss: Are Banana Chips A Healthy Snacking Option? Nutritionist Tells - NDTV

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BOWLING GREEN, Ky. On Tuesday, double Board Certified Plastic Surgeon, Dr. Bernard Salameh MD, FACS ABPS ASPS, and founder of Salameh Plastic Surgery, Hair Transplant, Medical Spa and Skin Care will appear on the Emmy Award-Winning television show CBSs The Doctors as he surprises a guest on the show with complimentary life changing full body contouring after the guest lost over 400 pounds.

In this episode, The Doctors will feature Justin Wiseman, a 36 year-old from rural Illinois, who has struggled with his weight his entire life. By the age of 5, he was 100 pounds. He eventually tipped the scale at 620 pounds by the time he was 26 years old. He started reaching out to doctors for help, but quickly learned that operating room tables had a 500-pound limit, so he had no choice but to lose the weight on his own.

He made small changes to lose 130 pounds in six months before undergoing bariatric surgery. After three years, he reached his goal weight of 180 and had lost 440 pounds. However, like 85% of those who lose weight, a traumatic life event led him to gain 200 of those hard-earned pounds back.

Since then, he has decided to tackle his food addiction and mental health. He has lost 130 pounds in the past year, with 70 pounds to go until he reaches his goal weight. With his 3-year-old daughter as motivation, he has regained his passion for healthy living and enjoys teaching the benefits of a healthy lifestyle to children.

Inspired by Justins hard work, back story, and dedication to living a healthy lifestyle, Dr. Salameh is donating a series of skin removal and body contouring procedures, at no charge,once Justin reaches his goal weight. Upon achieving his goal weight, Dr. Salameh will work with him to create a custom treatment plan to remove excess skin, caused by extreme weight loss, and fat in the upper body, lower body, and face. Dr. Salameh wants to give Justin his confidence and sense of self being back by giving him the body he has worked so hard to achieve.

After hearing about Justins story and the struggles of weight loss and gain, I knew I had to do something, said Dr. Salameh. He is a true inspiration to many people who can relate to his story and I am just so proud of everything he has accomplished. With this gift, I hope this will give him the motivation he needs to reach his final goal. I cannot wait to change his life.

CBS and The Doctors will continue to follow Justin Wisemans story and transformation over the next year with additional episodes featuring his journey with Dr. Salameh. In addition to his story being covered by The Doctors, you can find behind-the-scenes videos and more on the YouTube channel for Salameh Plastic Surgery.

Read the rest here:
Dr. Bernard Salameh to appear on CBS Television Distribution's The Doctors - wnky.com

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November 2020:

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Increase in the Adoption of Testosterone Replacement Therapy to Propel the Growth of the Testosterone Replacement Therapy Market Between 2020-2027 -...

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Transparency Market Research (TMR)has published a new report titled, Testosterone Replacement Therapy Market Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 20192027.According to the report, the globalTestosterone Replacement Therapy marketwas valued atUS$ 1,613.7 Mnin2018and is projected to expand at a CAGR of4.4%from2019to2027.

Overview

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Growing Awareness about Testosterone Replacement Therapy to Drive Market

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Testosterone Replacement Therapy Market projected to expand at a CAGR of 4.4% from 2019 to 2027 - Eurowire

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Testosterone Therapy Marketresearch report is the new statistical data source added byA2Z Market Research.

Testosterone Therapy Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

Testosterone Therapy Marketreport focused on the comprehensive analysis of current and future prospects of the Testosterone Therapy industry. This report is a consolidation of primary and secondary research, which provides market size, share, dynamics, and forecast for various segments and sub-segments considering the macro and micro environmental factors. An in-depth analysis of past trends, future trends, demographics, technological advancements, and regulatory requirements for the Testosterone Therapy market has been done in order to calculate the growth rates for each segment and sub-segments.

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Top Key Vendors of this Market are:

AbbVie Inc, Actavis Inc, Eli Lilly & Co, Auxilium Pharmaceuticals.

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Testosterone Therapy market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Testosterone Therapy markets trajectory between forecast periods.

The report provides insights on the following pointers:

Market Penetration:Comprehensive information on the product portfolios of the top players in the Testosterone Therapy market.

Product Development/Innovation:Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Market Development:Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

Market Diversification:Exhaustive information about new products, untapped geographies, recent developments, and investments in the Testosterone Therapy market.

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Regions Covered in the Global Testosterone Therapy Market Report 2020:The Middle East and Africa(GCC Countries and Egypt)North America(the United States, Mexico, and Canada)South America(Brazil etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

The cost analysis of the Global Testosterone Therapy Market has been performed while keeping in view manufacturing expenses, labor cost, and raw materials and their market concentration rate, suppliers, and price trend. Other factors such as Supply chain, downstream buyers, and sourcing strategy have been assessed to provide a complete and in-depth view of the market. Buyers of the report will also be exposed to a study on market positioning with factors such as target client, brand strategy, and price strategy taken into consideration.

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Table of Contents

Global Testosterone Therapy Market Research Report 2020 2026

Chapter 1 Testosterone Therapy Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Testosterone Therapy Market Forecast

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Comprehensive Report on Testosterone Therapy Market 2020 | Size, Growth, Demand, Opportunities & Forecast To 2026 | AbbVie Inc, Actavis Inc, Eli...

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Read the Full Video Transcript

Alicia Morgans: Hi, my name is Alicia Morgans and I'm a GU medical oncologist and Associate Professor of Medicine at Northwestern University. I am so excited to have here with me today, Dr. Dan Spratt, who is a Professor of Radiation Oncology at the University of Michigan, and he will be talking to us about the role of ADT in men who are receiving radiation therapy. Thank you so much, Dr. Spratt.

Daniel Spratt: Thank you so much, Dr. Morgans. It's great to be here talking about this topic, which is, obviously close to me as a radiation oncologist and I have no relevant disclosures for this talk. And so, before I get into the role of hormone therapy with radiation, I think it's important to take a step back real quick about just the role of hormone therapy in prostate cancer.

The very first case of prostate cancer was in the mid 1800s, and it took almost a hundred years before the first effective treatment for prostate cancer really emerged, which Dr. Huggins and Hodges won a Nobel Prize for, with surgical castration showing us improved outcomes for men with metastatic prostate cancer. And then it took another 40 years for the first FDA approved agent, leuprolide, which is an LHRH agonist, which suppresses testosterone, which is still likely the most common form of hormone therapy used today, at least the United States. And then shortly thereafter, one of the first anti-androgens was approved, flutamide, which is a drug given usually three times a day.

But, there was quite a bit less progress the next 20 years. There was docetaxel, but the next big drug in the category was degarelix, which was the first GnRH antagonist approved in 2008. And then the past 12 years or so, new drugs had exploded, many of which were hormone therapy or AR signaling inhibitor drugs, including abiraterone, enzalutamide, apalutamide as well as darolutamide, and numerous other approvals shown here.

And so, while this was all ongoing, the study of radiotherapy with hormone therapy was occurring in parallel. And so, one of the very first studies was an old RTOG trial in the mid 1970s. It was a pretty big trial, 566 patients. This is how they used to stage prostate cancer back then. But these were very advanced node-positive prostate cancer, and it was a question nothing to do with hormone therapy. It was about how much radiation could you give to the lymph nodes. But they found on a very simple multi-variable analysis, that the use of hormones, which really this is hormone therapy or ADT, had a trend for improvement in what they called local control, which was just measured by a rectal exam.

And this was a promising enough signal they ran a Phase II trial shortly thereafter of 30 patients, all accrued in one year. And again, really bulky primary tumors and clinical node-positive disease. And they gave four months of an LHRH agonist and flutamide. At that time, how they assessed response was the DRE, and 28 of the 30 patients, they said had primary tumor clearance, measured by DRE, because these were stuck in bulky primaries.

Then subsequently, they followed this with a Phase III trial. And again, this was very locally advanced disease. You could have lymph nodes all the way up into the para-aortic nodes, which today we would call metastatic disease, and they randomized radiation therapy upfront, versus radiation therapy plus hormone therapy with just an LHRH agonist until progression. Those in arm one, they would add hormone therapy at time of relapse. And this is really one of the first randomized trials that showed that there was a reduction in metastatic disease in men receiving hormone therapy, as well as a improvement in survival, at least for the high Gleason score tumors, Gleason 8 to 10.

This in parallel, was done with, again, a trial where in non-metastatic patients, at least by the imaging at the time, with very bulky primaries, so this is a 25 cm2 gland. These are very big prostates. It was radiation alone +/- 4 months of combined androgen blockade, and as you see here, improvements in prostate cancer-specific mortality and a trend, but didn't lead significance for improvement in overall survival. So this was really the dawn of the era.

I won't go through, there's probably about 40 other trials, and this slide sort of is a highlight reel that over the next 30 years, there's been many trials assessing the addition of hormone therapy, assessing various durations of hormone therapy, some assessing use of neoadjuvant hormone therapy before radiation, some assessing adjuvant and prolonged adjuvant. And the summary of all of this work to oversimplify it is that in today's risk grouping, we usually use NCCN risk groups, for low-risk men, often now we don't even treat them with upfront therapy like radiation, but we definitely don't add hormone therapy. For select intermediate-risk men, we often, from these studies learn, we should be adding 4 to 6 months of a short-term hormone therapy. And for our higher risk men, to give them longer term, usually 18 to 28 months of hormone therapy.

This is hot off the press. We just presented this work last week and this paper will be published in JCO soon, and so people watching this can see the conclusions. We did a meta analysis of the two trials of intermediate-risk patients, where I just said you can give short-term hormone therapy, and we were trying to figure out that optimal timing of it, whether you should use an adjuvant or a neoadjuvant approach. And in this meta analysis of randomized trials, what we found, interestingly, was that all endpoints favored, that were significant, except for PCSM and overall survival, all favored the use of this adjuvant approach with the winning arm here. So, sequencing, in addition to duration, may be very important.

And so, all of what I've talked about so far is really oncologic outcomes, survival-type outcomes, but that's really only half the story when you're talking about hormone therapy, because quality of life is equally important, and to some patients, potentially more important to them. And it's very easy for scientists and researchers and clinicians to focus on the tumor response, but we really need to be weighing the harm, or the efficacy of our drugs to cancer, versus to the patient itself. We all too often focus when we look at things, like hormone therapy, on does it include the PSA values or various imaging results or the rectal exam findings and that early study of tumor progression. But we must remember that our treatments can harm quantity and quality of life in select patients.

And so, one of these studies, I like to always highlight is a big randomized trial done, called RTOG 96-01, which is a trial of men with recurrent prostate cancer that were randomized to receive radiation with either a placebo, or 2 years of high-dose bicalutamide and antiandrogen by itself. And what we've shown is that in men receiving early salvage radiation therapy, there's a two-fold increased risk of other cause mortality, dying of something other than prostate cancer, which was driven by a high-grade, predominantly cardiac toxicity, about a three-fold increase. This has been shown in select other studies with high-dose bicalutamide, and so again, we can't just focus on improvements in biochemical recurrence, we need to think about the overall benefit to the patient.

So hormone therapy has a variety of side effects discussed. On the right, in pink here, these are often metabolic-type side effects. On the left, these are very common things we think about. Loss of libido, erectile dysfunction, hot flushes. So some are mild, some are annoyances, but some can be serious for select patients. One that's often not probably discussed enough as this is a large meta analysis of over 150,000 patients, is hormone therapy has been shown, likely, to increase the risk of development of depression, and depression can be of various scales and severity, and so is important. And NCCN guidelines has a screening tool for this for patients.

One of the other issues with hormone therapy, especially when we're talking about with radiation where we're usually giving it for a finite period of time, it's not usually a lifelong, it's for 6 months or 18 months, is this is one of those trials that established, that compare 18 months of hormone therapy versus 36 months of hormone therapy with radiation. And although that's the duration they intended to give, it takes a long time to recover testosterone. And what you see here, is that it takes almost over double the duration that was given to recover. So for 18 months of hormone therapy, it took 3.5 years to recover back to normal testosterone, and for the 36 months, took a total of 6.6 years. And that's from initiation of hormone therapy. But what's also is important as you see that, despite this very long-term follow-up, 20% to 40% of men never even recovered back to normal testosterone levels.

This is similar and this surprises a lot of people when they actually look at this data that you've been short-term hormone therapy for 6 months is that you can see here, this is just the timing of hormone therapy, but it's 6 months in both arms, that again, starting at the initiation of that hormone therapy, keeps it low for 6 months, but it took almost an additional year for most men to get back up to normal testosterone, and still, about 20% of men have still not recovered to normal testosterone by years after treatment.

And so, it is exciting, and this is other work we presented recently, as well as this is published in the New England Journal, is the use of this novel GnRH antagonist called relugolix. Prior to the randomized trial I'll show you, they ran a Phase II randomized trial of this novel oral GnRH antagonist, relugolix, compared it to degarelix, the drug that I told you that was approved in 2008 that's an injectable given monthly, and both showed very good sustained castration levels over this 24-week period, but actually, relugolix had faster time, slightly, to achieve castration, but also a faster recovery time of testosterone after.

And what's even more impressive is their Phase III trial, which the majority of patients probably in the United States don't use degarelix, they receive leuprolide or something like leuprolide, and this was a big multi-national trial, over 900 patients. It's a registration trial, trying to get approval for relugolix. It was designed as a non-inferiority trial to achieve sustained castration of testosterone levels over a 48-week period with multiple secondary endpoints. A subset of these patients, given those talks about the use of radiation, that subset of these patients, about 150 of them, received radiation therapy with one of the two forms of hormone therapy, and it was primarily external beam radiation with the primary or curative setting or the salvage setting where we often deliver radiation therapy.

What you see here on the left, this are the overall trial results. Relugolix was not only non-inferior, it was actually superior to leuprolide, where 96.7% of patients had sustained castrate rate levels of testosterone, versus 88.8% with leuprolide. And similarly, as would be expected, those in the radiation therapy cohort had similar excellent sustained castration with the use of relugolix.

The secondary endpoints are also very interesting. They looked at, in the first column here, is testosterone suppression less than 50 nanograms per deciliter, but by day 4. And so what's amazing is, almost 60% of patients that received relugolix, and this is again, the radiation therapy subset, already had castrate testosterone and obviously none with leuprolide. And even by day 15, all the patients with relugolix were already castrate, and only 10% with leuprolide. And as even you can see with PSA responses that, of course, the testosterone goes down as expected, the PSA responds as well.

That's one of the advantages is this early, the left side of this, is comparing testosterone levels over time, as it's more rapidly you achieve castration, but it's very interesting as the tail of these curves. As I showed you with leuprolide, it can take years to recover to normal testosterone. Relugolix, you can see that within 90 days, which is just 3 months, over half of the men already had achieved normal testosterone levels. So this is something unprecedented that will allow future studies to tailor the on-and-off switch of how long you actually really want them to be under hormone therapy or castration.

And finally, a very exciting area that has been shown signals in other trials and studies, is they also showed this was not a pre-specified endpoint, but they did pre-specify they'd collect this data for safety, is they showed a significant reduction in major adverse cardiac events, which, as I showed you from that prior study of use of bicalutamide, for example, a substantial increase in risk of cardiac events. And so again, this is something, combined with prior data, that's at least promising, interesting, that requires further study.

So I think in summary, hormone therapy or ADT improves many important oncologic outcomes for men treated with radiation therapy. It's been shown in the correct patient populations to reduce recurrence of disease, reduce the development of metastasis, and even helps many men live longer. But we also must balance this with the side effects of hormone therapy, and we must personalize this risk-benefit ratio. Many of the side effects are minor annoyances, especially with short-term therapy, but some may be serious and patients need to be counseled on this. What is very exciting, as newer forms of ADT, especially a novel oral GnRH antagonist, if approved, does have, especially in combination of radiation therapy, many advantages given it's fast on-and-off mechanism, potentially, this cardiac reduction in side effects as well. So thank you so much.

Read more from the original source:
The Role of ADT in Men Being Treated with Radiation Therapy Presentation - Michael Cookson, Alicia Morgans & Daniel Spratt - UroToday

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