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Weight Loss Journey from 19 stone and size 22 to 9 stone and size 10

ByAideen O'Flaherty

While many of us have been struggling with managing our weight during the past few months, one woman reached her target weight during the lockdown after losing ten stone and dropping from a size 22 to a size 10.

Audrey Higgins (37) started her weight loss journey almost three years ago, when she weighed 19 stone, after she noticed she wasnt as active with her daughter as she wanted to be, so she signed up for Slimming World and she now attends the Plaza Hotel group which is run by Christine Byrne.

Audrey before her weight loss (Left) andAudrey after her impressive 10 stone loss

I had a small child at the time, remembered Audrey. I was raising my daughter on my own and I worried a lot about not being around, because everything is a struggle when youre heavy.

I saw a picture of myself, and I saw that I was taking up the space of two people because of my size.

I looked at it and I thought, I wont be around for long.

The mother-of-one gradually lost the weight, but she said it took her a while to feel the difference that her lifestyle changes were making.

It took me two years and ten months, overall, to lose the ten stone. Its important to remember that its not a race and that youre doing it for yourself.

I found that the slower I lost the weight, the better.

She added: I was so big that I wouldnt have seen two stone off me, I just wouldnt have noticed it.

I didnt feel the difference until I lost four stone.

Audrey said losing the weight didnt feel like a chore, and she never felt like she was on a diet on Slimming World because it gave her many different food options.

Slimming Worlds plan suits everybody, she said. It caters to every lifestyle and every diet they even have vegan and vegetarian options.

Theres no pressure on you to lose weight quickly, and everyone in the Plaza group is extremely friendly. Ive made friends for life there, and the leaders are so encouraging.

Audrey, who is a clerical worker, hit her target weight during the lockdown, and is excited about the difference its made to her life.

It feels great, but I think it will take well over a year for me to adjust, she said. Because I was so big for so long, I never had any colour in my wardrobe everything was black and in the biggest size.

Now I feel like a totally different person, Im not lazy and Im not sluggish anymore.

During lockdown, Slimming World continued their classes on Zoom to ensure their members could continue to receive support during the pandemic and get closer to reaching their target weight.

Pauline Mooney, a Slimming World consultant and team developer for the Tallaght area, told The Echo: Slimming World is famous for its service to members, and one of our statements is that were here for the 52 weeks of every year.

We moved everything online when the lockdown started, and having that online presence is great because it gives everyone a different focus from coronavirus.

Members are continuing to reach their target weight, but I think the most important thing is that they realise theyre not on their own they have the support of the consultants and the members.

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Weight Loss Journey from 19 stone and size 22 to 9 stone and size 10 - The Echo Newspaper

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In 2016, Andrew Tye, a fine-dining chef with an extensive culinary background, landed a job with Counter Logic Gaming (CLG), an eSports team based in Los Angeles.

If that sounds strange, Tye would agree that it is, especially if you consider his training.

Tye began his professional cooking career in Canada when he was 14. He eventually went to Fleming College, during which he competed in a nationwide cooking competition where he came in fifth. From there, he could have had a job at any restaurant he wanted.

But instead, after watching an AMA on Twitch with the founder of CLG, George "HotshottGG" Georgallidis, Tye decided to go a different direction. He'd long been a fan of eSports, or high-level video game competitions. "CLG had been my favorite team for a couple years by that point," he says. So he reached out to CLG and offered his talents.

Two weeks later Tye became a CLG employee as head of food operations, which feeds players, operations, and staff. And just like athletes in other sports, Tye occasionally works with a dietitian to develop nutrient-dense meals that are caters to individual player needs.

If you cant wrap your head around a keyboard and mouse as pieces of sports equipment, it's time to catch up.

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Michael Jordan has invested in eSports. CLG is one of Madison Square Gardens franchises. Newzoo, a games analytics company, reports that the eSports industry made $1.1 billion dollars in revenue in 2019, which was a 26.7 percent growth from 2018. (By comparison, the NHL has a yearly revenue of $5 billion.)

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eSports teams are structured like other sports teams. There are general managers that oversee roster construction and contract negotiation. There are coaches that work with teams to design game strategies. There are scouts the recruit players. And those players train.

CLG athletes train at a performance center, where they practice for up to 12 hours a day during the season, says Matt Nausha, head of eSports for CLG. (Seasons are also known as "splits.")

For CLG athletes, most practice days start around 10:30 a.m. with exercise or group yoga. Around 11:30 the athletes eat breakfast, followed by a team meeting to discuss strategy. Then they enter into a five-and-a-half-hour-long block of playing and reviewing their performance. Dinner is held family-style with players and staff, and then it's either back to more practice, language lessons, or team meetings.

Michael Fricke/CLG Photos

"This is why its important the players are well nourished to sustain optimal energy throughout the day," Nashua says. "By providing meals they can maximize their time to focusing on training."

"Sustained energy is key," Tye says. "Our guys are training differently from traditional sports where they're trying to gain muscle mass or get leaner. Our guys are sitting in front of a computer screen and we need to minimize issues of fatigue from sitting for long periods of time and the strain of looking at a screen all day."

"Sustained energy" is why Tye mostly sticks to a high-protein, low-carb diet for the players. "We don't avoid carbs completely since its one of the preferred sources of energy for our bodies, but having very carb-heavy meals can induce sleepiness, which we want to avoid."

Michael Fricke/CLG Photos

Breakfast offers bacon and eggs, high-protein Kodiak pancakes, and 'muscle muffins.' (Soy chorizo omelettes are a favorite of Kevin "PewPewU" Toy, 25, a Smash Bros. Melee player.) There are also mounds of fresh fruit, a rotating array of oatmeals, like banana toffee with molasses and shredded coconut. "Oatmeal is a low glycemic index source of carbohydrates which is better for sustained energy," he says.

At lunch, theres a large salad bar and prepared panini and wraps, like chicken breast with arugula and fresh mozzarella or a curry chicken salad, a favorite of Fortnite player Kevin "Tocata" Larreinaga.

And dinner is where Tye flexes. He'll usually try to make meals the players haven't had before or "something colorful." Meals like street-style tacos with carnitas, cotija cheese and a slaw of roasted corn, red onion, and jalapeno, or bacon-wrapped pork roulade stuffed with herbs a garlic served with a blueberry gastrique.

Michael Fricke/CLG Photos

Sometimes, meals help the teams 'foreign-born players cope with their new home in the United States. "To cater to our Korean players with homesickness, we do some homestyle Korean meals, such as egg -ried tilapia and green onion pancake," he says.

Tye also doesnt shy away from making plant-based meals. He'll do panko-fried tofu with ginger, garlic, and scallion oil, or vegan lasagna, a favorite of Mathew "xSojin" Perez, League of Legends assistant coach.

And while Tye can't take all the credit, his meals seem to be fueling CLG's success. The group's League of Legends team went 2-0 last weekend, which makes their current record 3-1 and has landed them tied for second place in the league.

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What an Elite eSports Team Eats, and the Chef That Feeds Them - Men's Health

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While the absence of tourists during the coronavirus pandemic may have deprived Naras famous deer of their favourite snack, it has worked wonders for their digestive health.

Before the outbreak, millions of tourists descended on the western Japanese city once the countrys capital to view its shrines and temples, and feed the estimated 1,300 free-roaming deer in the its main park

While their preferred snack of senbei rice crackers are a nutritious combination of flour and rice bran, the deer simply ate too many of them, triggering a raging thirst.

I suspect some deer ended up drinking too much water, Yoshitaka Ashimura, secretary-general of the foundation for the protection of deer in Nara, told the Asahi Shimbun newspaper.

That, he said, took a toll on the animals health, causing gastrointestinal problems such as diarrhoea.

But now, deprived of their regular supply of senbei crackers, the deer have been forced to seek out more of their traditional staple diet of plants and nuts.

The result has been a transformation in their health, evidenced by the piles of perfectly formed pellet-like droppings affectionately referred to as black beans.

Naras deer, which have been known to attack visitors who tease them with food or try to take selfies with them, are believed to be divine messengers and were designated natural treasures in 1957.

The animals have the dramatic plunge in visitor numbers to thank for their improved bowel movements.

An estimated 2.58 million people visited Nara prefecture in 2018 an almost 10-fold increase from 2012 leading to a spate of deaths among animals who swallowed plastic bags and food wrappers discarded by tourists.

In May, however, just 1,700 people visited Japan from overseas a 99.9% drop from the same month last year as a result of travel bans and other restrictions prompted by the Covid-19 pandemic.

While the trend has hit businesses in Nara, it has brought an unexpected benefit for residents.

Not only are the animals droppings more compact, said Toshiharu Takaki, a regular visitor to the deer park for 40 years, they also stink less.

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Scat feels better: digestive health of Japan deer improves as tourist snacks dwindle - The Guardian

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With the UK on the brink of a deep recession and many households facing increasing financial pressure as a consequence of coronavirus, IGDs Chief Economist James Walton explores the relationship between health and wealth and highlights some key considerations for food businesses.

IGD has created hypotheses describing possible long-term effects of Coronavirus on business, health and sustainability. The six hypotheses connected to health and wellness are, briefly:

(A complete discussion of these can be downloaded here LINK)

A strand that links some of these hypotheses together is economics economic outcomes shape the choices made by shoppers and governments.

Unfortunately, the economy of the UK and other Western nations was not performing strongly before the emergence of Coronavirus, leaving little margin to cope with shock.

Average real household income in the UK was broadly flat between 2010 and 20191, household cash resources are limited2 and some households have spent less on food and drink over time3.

Economic pressure has now been amplified by Coronavirus and consequent lockdown measures; the UK government is predicting an exceptionally deep recession and a rapid increase in unemployment4.

Data from ONS suggests that this is already happening, with economic activity slumping and a deterioration in the labour market, with implications for the income of working age households.

Shoppers themselves seem despondent. IGDs ShopperVista surveys show that confidence in personal financial outcomes fell sharply in March and April 2020 in view of recent events, this view is not unreasonable.

Households that see income reduced will be forced to make new choices across the entire household budget, including food shopping.

Social welfare implications are concerning, since many UK households were food-stressed before Coronavirus, relying on food banks and school meals to supplement their diets.

Charities have reported a steep increase in demand the Trussell Trust distributed 81% more food parcels in March 2020 and 89% more in April 2020, when compared with the same months in 2019.

Looking ahead, it is hard to find cause for optimism. With Coronavirus still present and the challenge of EU exit approaching, a quick return to economic growth and better outcomes for households seems unlikely.

It is quite likely that the economic position of many households will worsen before getting better. This may happen rapidly and on a large scale, impacting shoppers at all income levels.

The association between low income and poor health is well-understood. Dietary choices differ markedly between the poorest and richest households in the UK.

Source: Family Food Survey 2017-18, ONS, February 2020

ONS data shows that UK households in the bottom income decile (ie: the lowest 10%) tend to consume far less fruit and veg than those in the top decile, for example5.

Differing diets are reflected in differing health outcomes. NHS data shows that adults are more likely to be overweight and obese when they report multiple indicators of deprivation.

Source: Health Survey for England 2018, NHS, 2019

If, as anticipated, the consequences of Coronavirus and EU exit cause citizens to become less well-off, then they may be expected to make new choices across all aspect of the household budget, including food.

This may mean that the dietary quality of much of the population may decline in the months and years ahead, rolling-back progress made over recent years.

This creates a daunting challenge for government and for public services, but it means challenges for food businesses also:

Amid the economic and biological gloom, it is hard to find much cheer, but there may be room for optimism in certain aspects of diet and health:

These points offer food businesses the chance to open new fronts in communication with shoppers and, more importantly, a chance to present positive messages in hard times.

Sources

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Coronavirus (COVID-19): impacts on health and wealth - IGD

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Move over, beef; veggies are whats for dinner. As more and more people become aware of the negative impact eating large amounts of meat has on the environment, vegetarian and vegan dining has gone from mocked hippie ideology to trendy mainstream lifestyle, combining the current wellness and health obsession with growing social consciousness and action against climate change. Embracing a plants-only diet is now more accessible and approachable than ever: vegan or vegetarian meals are available everywhere from the menus of world-renowned restaurants to your neighborhood diner. You can even find them in the frozen food aisle. But nothing beats a good home-cooked meal, so plant-based cooking is coming to the home kitchen, and cookbook authors are here to help.

Many of the food worlds top chefs, bloggers, restaurateurs, and writers are on a mission to show readers just how versatile and crazy-good vegetables truly are, and their books can teach you how to make everything from a meatless barbecue thats as good as the real thing to salads that have been elevated to an art form. Whether youre a newbie to plants-only eating or a long-term vegetarian or vegan looking for fun new recipes to try, these are the best vegan and vegetarian cookbooks to keep on your shelf at home.

As the Avant-Garde Vegan, Gaz Oakley is a superstar of the online vegan food world with over a million subscribers to his YouTube channel and nearly 500,000 followers on Instagram. Famed for his inventive, flavor-packed vegan recipes and infectious passion for cooking, earlier this year Oakley released his third book, Plants-Only Kitchen, which features over 70 recipes that run the gamut from breakfast dishes and burgers to desserts and sides. For ease and convenience, recipes are marked to show which are a quick 15-minute weeknight meal, which recipes are high in protein, which can be prepped in advance, and so on, making this a great book to turn to to find a recipe for every occasion.

Former New York Times food columnist Mark Bittmans How To Cook Everything series are some of the most ubiquitous cookbooks around; chances are you or someone you know has an edition on their shelf at this very moment, right next to Joy of Cooking. In the early aughts, Bittman was one of the first (alongside legends like Isa Moskowitz and Terry Romero) to try and show the American public just how approachable, healthy, and delicious meatless cooking could be with How To Cook Everything Vegetarian; the book was a runaway success and celebrated its ten-year anniversary in 2017. The updated version, which features everything from meat-free renditions of globetrotting classics like paella to creative salads and pasta for fast weeknight dinners, also has tons of new info and charts, as well as a beverage section for teas and smoothies.

Heralded as the ultimate guide to veganism, Veganomicon is a veritable bible that any vegan or vegetarian would be remiss not to have on their shelf. Written by two of most acclaimed vegan cookbook writers of our time restaurateur, chef, and Post Punk Kitchen creator Isa Moskowitz and bestselling cookbook writer Terry Romero it was first published in 2007 as part of the first wave of plants-only cookbooks aimed at the general public. Now a staple of the genre, the new tenth-anniversary edition features over 250 lip-smacking vegan recipes, as well as low-fat, gluten-free, and soy-free options and plenty of gorgeous photos to inspire and delight. The book also outlines cooking and prep techniques, so if youre a beginner, Moskowitz and Romero are there to guide you, with a healthy dose of their sassy, smart wit added for good measure.

Chef Jos Andrs is known for many things: his innovative small-plates presentation, his many restaurants around the States, and, perhaps most notably, his charity work with World Central Kitchen, a non-profit that provides healthy meals to survivors in the wake of a natural disaster. But in addition to feeding the world, Andrs boundless energy and enthusiasm is also dedicated to a different quest: Getting people to be as in love with vegetables as he is, which is the core goal of Vegetables Unleashed. This passionate cookbook, written with food writer Matt Goulding, shakes up old ideas about vegetables and veggie-only recipes to show the true breadth of vegetarian cooking, as Andrs shows readers how to create dishes from around the world using only vegetables, as well as getting creative with tried-and-true staples like lentil stew. If you have ever thought that vegetarian dining was boring or staid, this book will prove you wrong.

Transforming the diverse, vibrant dishes and cuisines of the African diaspora into vegan and vegetarian-friendly meals, chef and activist Bryant Terrys beloved 2014 cookbook takes readers and eaters on a journey of culinary and historic discovery. A pioneer of the food justice movement, which states that everyone has the right to healthy, high-quality meals, Terry educates his readers on the versatility and power of plant-based cooking, showing how traditional recipes can evolve and change while still remaining true to their heritage and culture. In between over a hundred delicious African, Caribbean, and Southern recipes like a Brazilian cashew-coconut soup that uses southern ingredients, youll also find thoughtful musings on the nature of food and community, as well as book and music recommendations.

If youre the kind of cook who loves elegant, restaurant-style plating and trendy preparation techniques, this elevated vegetarian cookbook from Michelin-starred chef Jeremy Fox and restaurateur Noah Galuten will be right up your alley. The stylish tome is a reverential treatise on vegetables as seen and handled through a chefs expert eyes and hands, with the authors explaining how to bring out and best express the many flavors, textures, and smells of vegetables through 160 innovative recipes, like a carta da musica flatbread topped with truffled pecorino and decorative leaves.

Who says Latin food cant be vegan-friendly? Certainly not Terry Hope Romero, one of the co-authors of the best-selling Veganomicon and other vegan and vegetarian cookbooks. Its a well-known fact that many Latin American countries love their meat, from roasted pork and goat in Mexico to the steaks and asados of Argentina, but in her first solo cookbook, Romero transforms over 200 classic Latin American recipes, like tamales, empanadas, stews, and churros, into vegan-friendly alternatives without sacrificing flavor or texture. Romeros passion and love for her heritage and the culinary traditions of this multicultural part of the world shine through in every recipe, and she also brings her own delightful twist to some recipes, like breakfast crepes with un-dulce de leche and sweet plantains.

Fried chicken. Gumbo. Hot biscuits with butter. Southern food is the epitome of comfort, but sadly, most of it is not vegan-friendly. So if youre a Southern-food lover looking to go vegan, chef and blogger Jenn Claiborne is your guiding star. Her cookbook features 100 recipes for vegan-friendly Southern classics, like Cauliflower Fried Chicken and Jalapeo Hush Puppies, as well as her own inventive takes on staples like collard greens. And, of course, there are plenty of sweet potato recipes to go around, like Sweet Potato Cinnamon Rolls and Sweet Potato-Tahini Cookies. Having grown up in Atlanta, Claiborne also shares the history behind many beloved Southern dishes and ingredients, bringing context and insight into these iconic regional foods.

When you get in the habit of purchasing your produce from a supermarket instead of a local farmers market or CSA, you tend to forget about the seasonality of vegetables. Supermarket chains import veggies from all over the world regardless of whether theyre in season in your area, but learning to cook with the seasons is one of the best parts of embracing a plant-based diet. Its healthier for you and for the planet, and you develop a deeper connection to nature, as chef Josh McFadden discovered. His and food writer Martha Holmbergs James Beard award-winning cookbook is an ode to seasonality, full of wisdom and practical advice on the benefits of growing and eating with the seasons, shared over the course of 225 recipes. Equal parts cookbook and meditative text on living in tune with nature, Six Seasons is one of the most transformative, thought-provoking vegetarian cookbooks out there.

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The 9 Best Vegan And Vegetarian Cookbooks - The Manual

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Men's Health Month serves as a timely reminder for men to see their healthcare provider and raises awareness about the benefit of early detection. Menare more likely than womentosuffer from abroadspectrum ofissues rangingfrom heart diseaseand cancer tosubstance abuse, depression and suicide.

Thomas K. Donaldson, MD, chair of orthopaedics at Loma Linda University Health, shares tips that can make a big difference for the man in your life. Joints are what make the entire body tick, but theyre prone to wear and tear like any mechanical system, Donaldson says. Theyll function best and longer when you take care of them.

To help maintain your joint health, Donaldson recommends following these three quick tips:

Although you may not be able to completely prevent injury or avoid health conditions such as arthritis, following these simple tips can help safeguard your joints throughout your life.

Joints like motion, and the more they move, the less stiffness theyll have. Its important for people who work at a desk or computer to make sure theyre changing positions often and taking breaks to walk around and exercise their joints.

Dont push the body to the point of pain, but instead, listen to the body. Stretching before exercise can help limit some of the pain by loosening the ligaments that form the joints. If the body is still in pain, make sure its getting an appropriate amount of rest and water.

A healthy diet will lead to a healthy weight and overall mental and physical health. Weight impacts the strain on the hips and knees and can cause them to wear down prematurely. Additionally, foods that lower inflammation can help mitigate joint pain and tenderness. Ask a physician about the best way to get started.

Loma Linda University Healthproviders are committed to ensuring all patients have access to the care they need especially during this stressful time. Patients can schedule video visits byvisiting lluh.org/video-visits,MyChartor calling their provider.

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Head to toe men's health: The joints - Loma Linda University Health

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A new research report released by MarketsandResearch.biz with the title Global Testosterone Cypionate Injection Market Growth 2020-2025 covers the overall analysis of the market, detailing information about key players, sales, future trends, research findings, and current and future opportunities during 2020 to 2025 forecast period. The report significantly identifies the qualitative influence of various market factors on market segments and geographies. The report defines, segments the global Testosterone Cypionate Injection market and encompasses market potential, influential trends, and issues facing the market. The report categorizes segments the market on the basis of product type, application, technology, and region.

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Global Testosterone Cypionate Injection Market 2020 | Top Leading Countries, Consumption, Trends, Revenue, Challenges and Global Forecast 2025 - Galus...

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Alexion Pharma Receives European Approval for Ultomiris

Alexion Pharmaceuticals (ALXN) announced that its lead drug candidate Ultomiris has been approved by the European Commission. Ultomiris may now be used for treating adults and children with atypical hemolytic uremic syndrome in Europe. The drug candidate is the first and only long-acting C5 complement inhibitor that needs to be administered every eight weeks.

The European Commission based its data on two global, single arm studies of the drug candidate. One of these studies was conducted in adults while the other was conducted in children. Both the trials are still operational. The interim analysis involved 56 out of 58 complement inhibitor treatment-nave adults and 18 out of 21 complement inhibitor treatment-nave children. For the initial 26-week treatment periods, 54 percent of adults and 77.8 percent (interim data) of children showed Complete TMA Response.

In the 52-week follow-up period, 4 more adult patients and 3 pediatric patients demonstrated a Complete TMA Response that was validated after the 26-week Initial Evaluation Period. This additional data takes the overall Complete TMA Response of 61 percent in adults and 94 percent in children as shown in interim data.

The drug is expected to create a niche for itself in the market with its convenient dosage regimen of eight weeks. John Orloff, M.D., of Alexion said, Treatment with ULTOMIRIS offers convenient eight-week dosing, which we believe is preferred by patients because it provides them with greater flexibility and improved quality of life, while also reducing the burden on healthcare systems that currently face significant strain in many countries. Atypical HUS is an ultra-rare disease which impacts vital organs such as kidneys by damaging walls of blood vessels.

The company has established a Risk Management Plan for ULTOMIRIS for minimizing the risk of side effects for patients. The most frequently observed adverse reactions related to the drug were nausea, upper respiratory tract infection and headache, among others. ULTOMIRIS is known to cause meningococcal infections, however, aHUS studies did not report any such incident.

ULTOMIRIS was approved by the FDA in 2019 for treating aHUS in adult and pediatric patients of one month of age and older. The drug is also approved in the United States and Japan for treating adult patients suffering from paroxysmal nocturnal hemoglobinuria. In Europe, the drug is authorized for treating patients with PNH with hemolysis with clinical symptoms indicative of high disease activity. The companys application for marketing authorization as a treatment for aHUS is currently under review in Japan.

ULTOMIRIS works by controlling the C5 protein in the terminal complement cascade. The treatment is designed to be administered intravenously every eight weeks or every four weeks for pediatric patients less than 20 kg, following a loading dose.

Alexion is a biopharmaceutical firm and focuses on complement biology and inhibition. The company has two approved complement inhibitors and two enzyme replacement therapies in its portfolio. It also has robust development pipeline with a number of prospective therapies in advanced trial stages. The company seeks to work on developing novel molecules and their impact on core therapeutic areas such neurology and nephrology.

Intercept Pharmaceuticals Inc. (ICPT) reported that it has received a Complete Response Letter from the FDA with regard to its Fibrosis drug. The letter indicates that agency has found the predicted benefits of the drug candidate to be uncertain. The FDA has recommended the company to submit post-interim analysis efficacy and safety data. The FDA stated that it felt that the modest fibrosis effect was not clearly predictive of clinical efficacy,

Intercept had earlier indicated that it expected the review may take longer than the previously announced PDUFA goal date as the agency had postponed a tentatively planned advisory committee meeting. Mark Pruzanski, M.D.,CEO of Intercept said, At no point during the review did the FDA communicate that OCA was not approvable on an accelerated basis, and we strongly believe that the totality of data submitted to date both meet the requirements of the Agencys own guidance and clearly support the positive benefit-risk profile of OCA. The FDA has recommended the company to continue the long-term outcome phase of its trial.

The NDA submission for obeticholic acid is the first for NASH. The application was backed by the data collated from 35 clinical trials. OCA is the only investigational NASH drug to demonstrate replicable ability to overturn or stabilize liver fibrosis in patients with advanced fibrosis due to NASH. The FDA has asked Intercept to submit additional data from its ongoing REGENERATE study to support its potential accelerated approval pathway.

There is no approved therapy for treating NASH fibrosis yet. OCA has been given Breakthrough Therapy designation by the FDA. The OCA is already approved by the FDA for treating primary biliary cholangitis.

Ascendis Pharma A/S (ASND) announced that it has submitted a Biologics License Application to the FDA seeking label expansion for TransCon. The company is looking to add the treatment of pediatric growth hormone deficiency to its label. Currently, there is no approved long-acting growth hormone treatment available in the United States or Europe.

TransCon hGH is a long-acting once-weekly prodrug of somatropin and aims to work on the same mode of action as daily daily hGH therapies. The drug candidate provides the therapeutic benefits by releasing the same growth hormone molecule, somatropin. Jan Mikkelsen, CEO of Ascendis said, We believe the TransCon technology has the potential to address major unmet medical needs and we look forward to continuing the late stage clinical development of our other endocrinology rare disease product candidates, TransCon PTH and TransCon CNP, as well as filing an Investigational New Drug application for our first oncology product candidate later this year.

The company plans to file a Marketing Authorization Application for the drug candidate in Europe during the third quarter. The drug candidate has orphan designation for GHD in both the United States and Europe. Ascendis plans to begin a new Phase 3 trial with TransCon hGH in pediatric GHD in Japan. The trial will likely be initiated in the fourth quarter. Another Phase 3 trial is currently underway in Greater China. Ascendis is collaborating with VISEN Pharmaceuticals for this purpose.

TransCon denotes Transient Conjugation and is a proprietary technology platform for producing more efficient therapies. The three main components of a TransCon molecule are an unmodified parent drug, an inert carrier to protect it and a liker to temporarily bind the two.

Ascendis Pharma has strong development pipeline with three independent endocrinology rare disease product candidates. The company is now looking to expand its focus on oncological segment.

Thanks for reading. At the Total Pharma Tracker, we do more than follow biotech news. Using our IOMachine, our team of analysts work to be ahead of the curve.

That means that when the catalyst comes that will make or break a stock, weve positioned ourselves for success. And we share that positioning and all the analysis behind it with our members.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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The Health and Safety Executive (HSE) says it carried out more than 1,000 spot checks in the first three weeks after it resumed inspections.

The safety watchdog restarted proactive inspections of construction and other sites in late May. Figures supplied to Construction News by the body for the three weeks between 26 May to 18 June show that the organisation carried out what it termed spot checks at 1,055 businesses across all sectors.

The organisation defines spot checks to include phone calls as well as site visits. It did not break down the figures between types of sector.

Some 107 firms who were subject to spot checks were subject to follow-ups from inspectors.

A spokesman said: HSE inspectors and local authority inspectors are visiting workplaces across a range of sectors following up reports or concerns about safety in the workplace including over COVID-19 and ensuring compliance. HSE is carrying out proactive checks to ensure that appropriate measures are in place to protect workers from COVID-19.

Putting duty holders on the spot, and checking on how they are managing risks has always been part of our regulatory approach.

The organisation has, however, suspended its release of RIDDOR statistics relating to the coronavirus, in what a spokesman said would be a temporary move while it refines its data collection processes. Up to the beginning of May, the organisation said there had been 198 RIDDOR reports of dangerous occurrences and 71 fatal-disease reports relating to COVID-19 across all industries.

One of the firms subject to an unannounced visit by inspectors was HGH Groundworks and Civil Engineering at a site where the firm is the largest subcontractor. Its head of safety, health, environment and quality Martin McCabe told Construction News that the inspector carried out a routine-style visit with added questions and checks on its processes for mitigating coronavirus.

It was an overall holistic visit where they were looking at everything. As a groundworks company they were pretty interested about the plant side of things and any issues [there could have been].

They asked about our processes, what we were doing about COVID-19 and how its managed.

The inspector found no issues on the site, McCabe said.

Last month Mike Clancy, general secretary of the Prospect union, which represents HSE inspectors, warned that the organisation would not be able to carry out spot checks with much frequency after it restarted work. The common understanding of what the HSE would do is much at odds with what it can do, due to its level of resourcing, he told CN.

See the article here:
HSE 'putting firms on the spot' over COVID-19 - Construction News

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This report also covers the impact of COVID-19 on the global market. The pandemic caused by Coronavirus (COVID-19) has affected every aspect of life globally, including the business sector. This has brought along several changes in market conditions.

The Infrared Search and Track IRST Systems Market report considers the major factors accountable for driving the growth of the Infrared Search and Track IRST Systems Industry, in addition to the key hindrances and challenges. In the initial segment of the report, the market definition, market overview, product description, product scope, product characterization, and product specification has been discussed. The information presented in this report provides an overview of the latest trends and development plans, patterns, and policies observed in the global market. Moreover, the study offers an analysis of the latest events such as the technological advancements and the product launches and their consequences on the global Infrared Search and Track IRST Systems market. The global market also comprises the data accumulated from numerous primary and secondary sources.

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TheMajorPlayers Covered in this Report: Leonardo S.p.A, Thales Group, Rheinmetall AG, Lockheed Martin Corporation, Northrop Grumman Corporation, Aselsan A.S., HGH Systmes Infrarouges SAS, Safran S.A., Tonbo Imaging Private Limited, Hughes Network Systems LLC, etc. & More.

Based on the Type:Airborne PlatformNaval PlatformLand PlatformOthers

Based on the Application:Defense SectorLaw EnforcementHomeland SecurityOthers

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Global Infrared Search and Track IRST SystemsMarket: Regional SegmentationFor further clarification, analysts have also segmented the market on the basis of geography. This type of segmentation allows the readers to understand the volatile political scenario in varying geographies and their impact on the global Infrared Search and Track IRST Systemsmarket. On the basis of geography, the global market for Infrared Search and Track IRST Systemshas been segmented into:

North America(United States, Canada, and Mexico)Europe(Germany, France, UK, Russia, and Italy)Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)South America(Brazil, Argentina, Colombia, etc.)Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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The information enclosed in this report is based upon both primary and secondary research methodologies.

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Key questions answered in this report:1. What will the market size be in 2026 and what will the growth rate be?2. What are the key market trends?3. What is driving this market?4. What are the challenges to market growth?5. Who are the key vendors in this market space?6. What are the market opportunities and threats faced by the key vendors?7. What are the strengths and weaknesses of the key vendors?

For More Details On this Report:https://www.reportsmonitor.com/report/978121/Infrared-Search-and-Track-IRST-Systems-Market

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