Search Weight Loss Topics:




Mar 31

Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation … – Nature.com

Silvestris, E., de Pergola, G., Rosania, R. & Loverro, G. Obesity as disruptor of the female fertility. Reprod. Biol. Endocrinol. 16, 22 (2018).

Article PubMed PubMed Central Google Scholar

Shah, D. K., Missmer, S. A., Berry, K. F., Racowsky, C. & Ginsburg, E. S. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet. Gynecol. 118, 6370 (2011).

Article PubMed Google Scholar

Andreas, E., Winstanley, Y. E. & Robker, R. L. Effect of obesity on the ovarian follicular environment and developmental competence of the oocyte. Curr. Opin. Endocr. Metab. Res. 18, 152158 (2021).

Article CAS Google Scholar

Richani, D., Dunning, K. R., Thompson, J. G. & Gilchrist, R. B. Metabolic co-dependence of the oocyte and cumulus cells: Essential role in determining oocyte developmental competence. Hum. Reprod. Update 27, 2747 (2021).

Article CAS PubMed Google Scholar

Van Hoeck, V. et al. Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: Mechanistic insights. Reproduction 145, 3344 (2013).

Article PubMed Google Scholar

Turner, N. & Robker, R. L. Developmental programming of obesity and insulin resistance: Does mitochondrial dysfunction in oocytes play a role?. MHR Basic Sci. Reprod. Med. 21, 2330 (2015).

Article CAS Google Scholar

Pratt-Phillips, S. E., Owens, K. M., Dowler, L. E. & Cloninger, M. T. Assessment of resting insulin and leptin concentrations and their association with managerial and innate factors in horses. J. Equine Vet. Sci. 30, 127133 (2010).

Article Google Scholar

Thatcher, C. D., Pleasant, R. S., Geor, R. J. & Elvinger, F. Prevalence of overconditioning in mature horses in southwest Virginia during the summer. J. Vet. Intern. Med. 26, 14131418 (2012).

Article CAS PubMed Google Scholar

Ragno, V. M., Zello, G. A., Klein, C. D. & Montgomery, J. B. From table to stable: A comparative review of selected aspects of human and equine metabolic syndrome. J. Equine Vet. Sci. 79, 131138 (2019).

Article PubMed Google Scholar

Harris, P. A., Bamford, N. J. & Bailey, S. R. Equine metabolic syndrome: Evolution of understanding over two decades: A personal perspective. Anim. Prod. Sci. 60, 2103 (2020).

Article Google Scholar

Johnson, P. J., Wiedmeyer, C. E., Messer, N. T. & Ganjam, V. K. Medical implications of obesity in horsesLessons for human obesity. J. Diabetes Sci. Technol. 3, 163174 (2009).

Article PubMed PubMed Central Google Scholar

Holbrook, T. C., Tipton, T. & McFarlane, D. Neutrophil and cytokine dysregulation in hyperinsulinemic obese horses. Vet. Immunol. Immunopathol. 145, 283289 (2012).

Article CAS PubMed Google Scholar

Sessions, D. R., Reedy, S. E., Vick, M. M., Murphy, B. A. & Fitzgerald, B. P. Development of a model for inducing transient insulin resistance in the mare: Preliminary implications regarding the estrous cycle12. J. Anim. Sci. 82, 23212328 (2004).

Article CAS PubMed Google Scholar

Vick, M. M. et al. Obesity is associated with altered metabolic and reproductive activity in the mare: Effects of metformin on insulin sensitivity and reproductive cyclicity. Reprod. Fertil. Dev. 18, 609 (2006).

Article CAS PubMed Google Scholar

Sessions-Bresnahan, D. R., Schauer, K. L., Heuberger, A. L. & Carnevale, E. M. Effect of obesity on the preovulatory follicle and lipid fingerprint of equine oocytes1. Biol. Reprod. https://doi.org/10.1095/biolreprod.115.130187 (2016).

Article PubMed Google Scholar

Morley, S. A. & Murray, J.-A. Effects of body condition score on the reproductive physiology of the broodmare: A review. J. Equine Vet. Sci. 34, 842853 (2014).

Article Google Scholar

Robles, M. et al. Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. PLOS ONE 13, e0190309 (2018).

Article CAS PubMed PubMed Central Google Scholar

Gastal, E. L., de Oliveira Gastal, M., Wischral, . & Davis, J. The equine model to study the influence of obesity and insulin resistance in human ovarian function. Acta Sci. Vet. 39(1), s57-70 (2011).

Google Scholar

Carnevale, E. M. The mare as an animal model for reproductive aging in the women. In Animal Models and Human Reproduction (eds Shatten, E. & Constantinescu, H.) 235242 (Wiley, 2017).

Chapter Google Scholar

Lazzari, G. Laboratory production of equine embryos. J. Equine Vet. Sci. https://doi.org/10.1016/j.jevs.2020.103097 (2020).

Article PubMed Google Scholar

Benammar, A. et al. The mare: A pertinent model for human assisted reproductive technologies?. Animals 11, 2304 (2021).

Article PubMed PubMed Central Google Scholar

Carnevale, E. M., Catandi, G. D. & Fresa, K. Equine aging and the oocyte: A potential model for reproductive aging in women. J. Equine Vet. Sci. 89, 103022 (2020).

Article PubMed Google Scholar

Catandi, G., Obeidat, Y., Chicco, A., Chen, T. & Carnevale, E. 167 Basal and maximal oxygen consumption of oocytes from young and old mares. Reprod. Fertil. Dev. 31, 208208 (2019).

Article Google Scholar

Catandi, G. et al. 98 Effects of maternal age on oxygen consumption of oocytes and in vitro-produced equine embryos. Reprod. Fertil. Dev. 32, 175175 (2020).

Article Google Scholar

Catandi, G. D. et al. Equine maternal aging affects oocyte lipid content, metabolic function and developmental potential. Reproduction 161, 399409 (2021).

Article CAS PubMed PubMed Central Google Scholar

Obeidat, Y. M. et al. Monitoring oocyte/embryo respiration using electrochemical-based oxygen sensors. Sens. Actuators B Chem. 276, 7281 (2018).

Article CAS Google Scholar

Obeidat, Y. M. et al. Design of a multi-sensor platform for integrating extracellular acidification rate with multi-metabolite flux measurement for small biological samples. Biosens. Bioelectron. 133, 3947 (2019).

Article CAS PubMed PubMed Central Google Scholar

Catandi, G. D. et al. Diet affects oocyte metabolism and developmental capacity in the older mare. Am. Assoc. Equine Pract. 65, 5152 (2019).

Google Scholar

Catandi, G. et al. Maternal diet can alter oocyte mitochondrial number and function. J. Equine Vet. Sci. 89, 103030 (2020).

Article Google Scholar

Catandi, G. D. et al. Oocyte metabolic function, lipid composition, and developmental potential are altered by diet in older mares. Reproduction 163, 183198 (2022).

Article CAS PubMed PubMed Central Google Scholar

Gonzalez, M. B., Robker, R. L. & Rose, R. D. Obesity and oocyte quality: Significant implications for ART and emerging mechanistic insights. Biol. Reprod. 106, 338350 (2022).

Article PubMed Google Scholar

Noland, R. C. et al. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J. Biol. Chem. 284, 2284022852 (2009).

Article CAS PubMed PubMed Central Google Scholar

Muoio, D. M. et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab. 15, 764777 (2012).

Article CAS PubMed PubMed Central Google Scholar

Vincent, J. B. New evidence against chromium as an essential trace element. J. Nutr. 147, 22122219 (2017).

Article CAS PubMed Google Scholar

Jamilian, M. et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilization: A randomized, double-blind, placebo-controlled trial. Biol. Trace Elem. Res. 185, 4855 (2018).

Article CAS PubMed Google Scholar

Jamilian, M. et al. Effects of chromium and carnitine co-supplementation on body weight and metabolic profiles in overweight and obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Biol. Trace Elem. Res. 193, 334341 (2020).

Article CAS PubMed Google Scholar

Seiler, S. E. et al. Obesity and lipid stress inhibit carnitine acetyltransferase activity. J. Lipid Res. 55, 635644 (2014).

Article CAS PubMed PubMed Central Google Scholar

Gervais, A., Battista, M.-C., Carranza-Mamane, B., Lavoie, H. B. & Baillargeon, J.-P. Follicular fluid concentrations of lipids and their metabolites are associated with intraovarian gonadotropin-stimulated androgen production in women undergoing in vitro fertilization. J. Clin. Endocrinol. Metab. 100, 18451854 (2015).

Article CAS PubMed Google Scholar

Igosheva, N. et al. Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS ONE 5, e10074 (2010).

Article ADS PubMed PubMed Central Google Scholar

Yang, X. et al. Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes. Fertil. Steril. 97, 14381443 (2012).

Article CAS PubMed Google Scholar

Boots, C. E., Boudoures, A., Zhang, W., Drury, A. & Moley, K. H. Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model. Hum. Reprod. 31, 20902097 (2016).

Article CAS PubMed PubMed Central Google Scholar

Sutton-McDowall, M. L. et al. Nonesterified fatty acid-induced endoplasmic reticulum stress in cattle cumulus oocyte complexes alters cell metabolism and developmental competence1. Biol. Reprod. https://doi.org/10.1095/biolreprod.115.131862 (2016).

Article PubMed Google Scholar

Carnevale, E. M. The mare model for follicular maturation and reproductive aging in the woman. Theriogenology 69, 2330 (2008).

Article CAS PubMed Google Scholar

Valckx, S. D. et al. Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: A descriptive cross-sectional study. Reprod. Biol. Endocrinol. 12, 13 (2014).

Article PubMed PubMed Central Google Scholar

Pantasri, T. et al. Distinct localisation of lipids in the ovarian follicular environment. Reprod. Fertil. Dev. 27, 593 (2015).

Article CAS PubMed Google Scholar

Gonzalez, M. B., Lane, M., Knight, E. J. & Robker, R. L. Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index. J. Reprod. Immunol. 130, 2529 (2018).

Article CAS PubMed Google Scholar

Valckx, S. D. M. et al. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum. Reprod. 27, 35313539 (2012).

Article CAS PubMed Google Scholar

Mirabi, P. et al. Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid?. Taiwan. J. Obstet. Gynecol. 56, 159164 (2017).

Article PubMed Google Scholar

Ribeiro, R. M. et al. Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity. Vet. J. 270, 105627 (2021).

Article CAS PubMed Google Scholar

Wu, L.L.-Y. et al. High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates. Endocrinology 151, 54385445 (2010).

Article CAS PubMed Google Scholar

Read the original:
Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation ... - Nature.com

Related Posts

    Your Full Name

    Your Email

    Your Phone Number

    Select your age (30+ only)

    Select Your US State

    Program Choice

    Confirm over 30 years old

    Yes

    Confirm that you resident in USA

    Yes

    This is a Serious Inquiry

    Yes

    Message:



    matomo tracker